Current Appointments & Affiliations
Professor of Medicine
·
2014 - Present
Medicine, Cardiology,
Medicine
Member in the Duke Clinical Research Institute
·
2002 - Present
Duke Clinical Research Institute,
Institutes and Centers
Recent Publications
Developing therapeutics for rare cardiovascular diseases.
Journal Article Am Heart J · February 2026 Rare cardiovascular diseases, while individually uncommon, collectively affect millions of people worldwide and are associated with significant morbidity, mortality, and economic burden. Despite this considerable impact, most rare cardiovascular diseases l ... Full text Link to item CiteEfficacy and Safety of Omecamtiv Mecarbil in Heart Failure With Reduced Ejection Fraction According to Age: The GALACTIC-HF Trial.
Journal Article JACC Heart Fail · February 2026 BACKGROUND: Older age is associated with a high prevalence of comorbidities and worse cardiovascular (CV) outcomes in patients with heart failure (HF) with reduced ejection fraction. Omecamtiv mecarbil, a selective cardiac myosin activator, exerts minimal ... Full text Link to item CiteLactate Dehydrogenase and Outcomes in Patients With HF and Reduced Ejection Fraction: Insights From GALACTIC-HF.
Journal Article JACC Heart Fail · January 10, 2026 BACKGROUND: Lactate dehydrogenase (LDH) is a cytoplasmic enzyme found in most cells. Increased LDH levels are a nonspecific measure of cellular injury and may be prognostically important in heart failure (HF). OBJECTIVES: This study aims to assess the rela ... Full text Link to item CiteRecent Grants
Omecamtiv Mecarbil CV Outcomes Trial
Clinical TrialPrincipal Investigator · Awarded by Cytokinetics, Inc. · 2024 - 2028Mid-Atlantic praGmatic NETwork for Inclusive Clinical trials in emergency care (MAGNETIC)
ResearchCo Investigator · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2028Integrated Biostatistical Training for CVD Research
Inst. Training Prgm or CMEMentor · Awarded by North Carolina State University · 2022 - 2027View All Grants
Education, Training & Certifications
Duke University ·
1993
M.D.