Scholars@Duke
Michael Dee Gunn

Michael Dee Gunn

Professor of Medicine
Medicine, Cardiology
Duke Box 102143, Durham, NC 27710
CARL Building Room 180B, Durham, NC 27703

Scholarly Works - Other

Figure 2 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

Other · October 18, 2024 <p>Stronger IFN-β responses to TLR1/2 stimulation associates with longer survival after sip-T therapy. <b>A,</b> HRs ± 95% CIs from a Cox proportional hazards model comparing induction of each cytokine (fold mock control) after TL ... Full text Cite

Figure 3 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

Other · October 18, 2024 <p>IFN-β induction after TLR1/2 stimulation associates with PBMC ELISpot responses to Fluzone, PHA, and CEFT (cytomegalovirus, EBV, Fluzone, and Tetanus peptide pool). <b>A,</b> ELISpot SFU after each indicated stimulant (<i&gt ... Full text Cite

Figure 1 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

Other · October 18, 2024 <p>Study design and <i>in vitro</i> responsiveness of PBMCs from patients with mCRPC to PRR agonist prior to sip-T treatment. <b>A,</b> Banked pretreatment PBMCs from the PRIME sip-T discovery cohort (<i>n</i& ... Full text Cite

Figure 5 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

Other · October 18, 2024 <p>TLR1/2 responses associate with post–sip-T survival independent of race and TLR1/2 SNP status. <b>A–C,</b> Survival stratified by race in the merged PRIME and KCI cohorts (<b>A</b>), PRIME cohort alone (<b>B&l ... Full text Cite

Data from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

Other · October 18, 2024 <div>Abstract<p>Mounting evidence links systemic innate immunity with cancer immune surveillance. In advanced metastatic castration-resistant prostate cancer (mCRPC), Black patients have been found to have increased inflammatory markers ... Full text Cite

Figure 4 from Peripheral Blood IFN Responses to Toll-Like Receptor 1/2 Signaling Associate with Longer Survival in Men with Metastatic Prostate Cancer Treated with Sipuleucel-T

Other · October 18, 2024 <p>Black race and TLR1-602I SNP associate with stronger responses to TLR1/2 stimulation. <b>A,</b> Supernatant cytokine release separated by Black (<i>n</i> = 15) vs. White (<i>n</i> = 91) for each stimulat ... Full text Cite