Michael Lucas James

Journal article J Womens Health (Larchmt) · April 2017 Featured Work BACKGROUND: Compared to ischemic stroke, sex differences in response to intracerebral hemorrhage (ICH) are largely unexplored, and their potential interactions with patient age have not been examined. This study hypothesized that risk for poor outcome is g ... Full text Link to item Cite

ApolipoproteinE mimetic peptides improve outcome after focal ischemia.

Journal article Exp Neurol · March 2013 Featured Work Growing clinical evidence implicates isoform-specific effects of apolipoprotein E (apoE) in reducing neuroinflammation and mediating adaptive responses following ischemic and traumatic brain injury. However, the intact apoE holoprotein does not cross the b ... Full text Link to item Cite

Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage.

Journal article Anesthesiology · December 2012 Featured Work BACKGROUND: Xenon has been proven to be neuroprotective in experimental brain injury. The authors hypothesized that xenon would improve outcome from focal cerebral ischemia with a delayed treatment onset and prolonged recovery interval. METHODS: Rats were ... Full text Open Access Link to item Cite

Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage.

Journal article J Clin Neurosci · August 2012 Featured Work Intracerebral hemorrhage (ICH) is a devastating and common admitting diagnosis to intensive care units in the USA. Despite advances in critical care, patients with ICH often experience early neurological deterioration (END) in the first 72 hours after admi ... Full text Link to item Cite

TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice.

Journal article Anesthesiology · June 2012 Featured Work BACKGROUND: Microglial inhibition may reduce secondary tissue injury and improve functional outcome following acute brain injury. Utilizing clinically relevant murine models of traumatic brain injury and intracerebral hemorrhage, neuroinflammatory response ... Full text Link to item Cite

Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach.

Journal article J Neurotrauma · May 1, 2012 Featured Work Traumatic brain injury (TBI) and intracerebral hemorrhage (ICH) are leading causes of neurological mortality and disability in the U.S. However, therapeutic options are limited and clinical management remains largely supportive. HMG-CoA reductase inhibitor ... Full text Link to item Cite

The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage.

Journal article Neurocrit Care · April 2012 Featured Work BACKGROUND: Apolipoprotein E has previously been demonstrated to modulate acute brain injury responses, and administration of COG1410, an apoE-mimetic peptide derived from the receptor-binding region of apoE, improves outcome in preclinical models of acute ... Full text Link to item Cite

Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice.

Journal article J Neurotrauma · January 2010 Featured Work There is emerging evidence to suggest that brain natriuretic peptide (BNP) is elevated after acute brain injury, and that it may play an adaptive role in recovery through augmentation of cerebral blood flow (CBF). Through a series of experiments, we tested ... Full text Open Access Link to item Cite

S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage.

Journal article Biomarkers · September 2009 Featured Work OBJECTIVE: To determine the predictive value of S100b and brain natriuretic peptide (BNP) in order to determine accurately and quickly a discharge prognosis after primary supratentorial intracerebral haemorrhage (ICH). METHODS: After IRB approval and infor ... Full text Link to item Cite

Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage.

Journal article Stroke · February 2009 Featured Work BACKGROUND AND PURPOSE: The purpose of the study was to evaluate the effect of APOE genotype and the feasibility of administering an apolipoprotein E-mimetic therapeutic to modify outcomes in a murine model of intracerebral hemorrhage. METHODS: Intracerebr ... Full text Link to item Cite

Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans.

Journal article J Stroke Cerebrovasc Dis · 2009 Featured Work INTRODUCTION: To address the mechanisms by which apoE polymorphism affects functional outcome after intracerebral hemorrhage in humans, we tested the hypothesis that the presence of the APOE4 allele results in amplified inflammatory responses and increased ... Full text Link to item Cite

Preclinical models of intracerebral hemorrhage: a translational perspective.

Journal article Neurocrit Care · 2008 Featured Work Intracerebral hemorrhage (ICH) is a devastating and relatively common disease affecting as many as 50,000 people annually in the United States alone. ICH remains associated with poor outcome, and approximately 40-50% of afflicted patients will die within 3 ... Full text Link to item Cite