Scholars@Duke
Michael Barry Kastan

Michael Barry Kastan

William and Jane Shingleton Distinguished Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
michael.kastan@duke.edu
MSRB3, 3 Genome Court, Box 103057, Durham, NC 27710
MSRB3, 3 Genome Court, Box 103057, Durham, NC 27710

Scholarly Works - Conferences

Abstract LB181: First disclosure of XRD-0394, a novel dual ATM/DNA-PK inhibitor, that potently radiosensitizes and potentiates PARP and topoisomerase inhibitors

Conference Cancer Research · April 5, 2024 AbstractA majority of cancer patients receive radiation therapy (RT) as part of their treatment regimens, whether using external beam therapy or locally-delivered radioisotopes. While often effective, RT may ... Full text Cite

Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways

Conference Molecular Cancer Research · April 1, 2017 AbstractThe ATM protein kinase and p53 protein are both central mediators of many aspects of DNA damage and cellular stress signaling. While there is a clear, direct relationship between ATM and p53, ATM has ... Full text Cite

Abstract IA11: New insights into DNA double-strand break responses

Conference Cancer Research · December 1, 2014 AbstractRepair of damaged DNA in cells is complicated by the necessity to repair the damage in the context of complex chromatin structures. Elucidation of molecular mechanisms of DNA repair in intact cells h ... Full text Cite

11 Unexpected New Insights Into ATM and p53

Conference European Journal of Cancer · July 2012 Full text Cite

Optimizing ATM inhibitor activity and specificity using pharmacophore-based docking

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · March 25, 2012 Link to item Cite

Roles of TP53 and ATM in radiation responses

Conference RADIATION RESEARCH, VOL 2, CONGRESS PROCEEDINGS · January 1, 2000 Link to item Cite