Scholars@Duke
Michael John Kelley

Michael John Kelley

Professor of Medicine
Medicine, Medical Oncology
michael.kelley@duke.edu
Duke Box 3396, Durham, NC 27710
508 Fulton St; Hem-Onc 111G, Durham, NC 27705

Featured Works

Influence of comorbidity on racial differences in receipt of surgery among US veterans with early-stage non-small-cell lung cancer.

Journal article J Clin Oncol · February 1, 2013 Featured Publication PURPOSE: It is unclear why racial differences exist in the frequency of surgery for lung cancer treatment. Comorbidity is an important consideration in selection of patients for lung cancer treatment, including surgery. To assess whether comorbidity contri ... Full text Link to item Cite

Phase II study of induction cisplatin and irinotecan followed by concurrent carboplatin, etoposide, and thoracic radiotherapy for limited-stage small-cell lung cancer, CALGB 30206.

Journal article J Thorac Oncol · January 2013 Featured Publication INTRODUCTION: We sought to determine the efficacy of using both irinotecan- and etoposide-containing regimens sequentially for patients with untreated limited-stage small-cell lung cancer. METHODS: Patients with untreated, measurable, limited-stage small-c ... Full text Link to item Cite

Cancer incidence among patients of the U.S. Veterans Affairs Health Care System.

Journal article Mil Med · June 2012 Featured Publication OBJECTIVE: Approximately 40,000 incident cancer cases are reported in the Veterans Affairs Central Cancer Registry (VACCR) annually (approximately 3% of U.S. cancer cases). Our objective was to provide the first comprehensive description of cancer incidenc ... Full text Link to item Cite

Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.

Journal article Blood · January 5, 2012 Featured Publication We have generated 3 mouse lines, each with a different mutation in the nonmuscle myosin II-A gene, Myh9 (R702C, D1424N, and E1841K). Each line develops MYH9-related disease similar to that found in human patients. R702C mutant human cDNA fused with green f ... Full text Link to item Cite

Molecular characterization of putative chordoma cell lines.

Journal article Sarcoma · 2010 Featured Publication Immortal tumor cell lines are an important model system for cancer research, however, misidentification and cross-contamination of cell lines are a common problem. Seven chordoma cell lines are reported in the literature, but none has been characterized in ... Full text Link to item Cite

T (brachyury) gene duplication confers major susceptibility to familial chordoma.

Journal article Nat Genet · November 2009 Featured Publication Using high-resolution array-CGH, we identified unique duplications of a region on 6q27 in four multiplex families with at least three cases of chordoma, a cancer of presumed notochordal origin. The duplicated region contains only the T (brachyury) gene, wh ... Full text Link to item Cite

Induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for regionally advanced unresectable stage III Non-small-cell lung cancer: Cancer and Leukemia Group B.

Journal article J Clin Oncol · May 1, 2007 Featured Publication PURPOSE: Standard therapy for unresectable stage III non-small-cell lung cancer includes concomitant chemoradiotherapy. In Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in im ... Full text Link to item Cite

Safety and efficacy of weekly oral oltipraz in chronic smokers.

Journal article Cancer Epidemiol Biomarkers Prev · April 2005 Featured Publication Cigarette smoking is thought to contribute to carcinogenesis by formation of DNA adducts of tobacco smoke constituents leading to genotoxic damage. The dithiolethione, oltipraz, is a putative cancer chemopreventive agent that induces phase II detoxifying e ... Full text Link to item Cite

Genetic analysis of the beta-tubulin gene, TUBB, in non-small-cell lung cancer.

Journal article J Natl Cancer Inst · December 19, 2001 Featured Publication Full text Link to item Cite

Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly.

Journal article Nat Genet · September 2000 Featured Publication May-Hegglin anomaly (MHA) is an autosomal dominant macrothrombocytopenia of unclear pathogenesis characterized by thrombocytopenia, giant platelets and leukocyte inclusions. Studies have indicated that platelet structure and function are normal, suggesting ... Full text Link to item Cite

Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans.

Journal article Proc Natl Acad Sci U S A · October 14, 1997 Featured Publication Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family. Portions of the gene encoding KGF were amplified during primate evolution and are present in multiple nonprocessed copies in the human genome. Nucleotide analysis of a rep ... Full text Link to item Cite

Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer.

Journal article Chest · July 1997 Featured Publication BACKGROUND: Small cell lung cancer (SCLC) cells express and secrete gastrin-releasing peptide (GRP) which binds to receptors and stimulates growth of these cells. A murine monoclonal antibody, 2A11, which binds GRP with high affinity, decreased growth of S ... Full text Link to item Cite

Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines.

Journal article J Natl Cancer Inst · May 17, 1995 Featured Publication BACKGROUND: The CDKN2 gene encodes the human cyclin-dependent kinase 4 inhibitor. This inhibitor protein is believed to be a tumor suppressor that plays an essential role in cell cycle regulation. One half of all cancer cell lines and one fourth of lung ca ... Full text Link to item Cite

Emergence of the keratinocyte growth factor multigene family during the great ape radiation.

Journal article Proc Natl Acad Sci U S A · October 1, 1992 Featured Publication The structural gene for human keratinocyte growth factor (KGF), a member of the fibroblast growth factor family, consists of three coding exons and two introns typical of other fibroblast growth factor loci. A portion of the KGF gene, located on chromosome ... Full text Link to item Cite