Michael D Lynch

Preprint · 2025 Two-stage bioprocesses which decouple cell growth from product synthesis are an attractive approach to biomanufacturing. However high levels of production in stationary phase cultures often suffer from a progressive decline in metabolism. We demonstrate th ... Full text Cite

Decoupling Central Metabolism from Catabolite Repression Enables Robust Cellulosic Sugar Co-consumption in E. coli

Preprint · 2025 Lignocellulosic biomass is the most abundant and sustainable carbon source for bioproduction, but its efficient utilization is hampered by the heterogeneous mixture of sugars released upon hydrolysis. Most industrial strains consume these mixed sugars sequ ... Full text Cite

Scalable, Robust, High-throughput Expression, Purification & Characterization of Nanobodies Enabled by 2-Stage Dynamic Control

Preprint · 2023 Full text Cite

Precipitation and Extraction Methods for Protein Purification: A Meta-Analysis of Purification Performance and Cost-Effectiveness

Preprint · 2023 Full text Cite

The Development of 2-stage Microfermentation Protocols for High Throughput Cell Factory Evaluations

Preprint · 2022 Full text Cite