Michael Patton

Journal article Neuropharmacology · November 2026 Neuroimmune signaling is increasingly implicated in alcohol use disorder (AUD). Microglia, the brain's resident immune cells, signal in part through the adaptor protein myeloid differentiation primary response 88 (MyD88), a key mediator of innate immune re ... Full text Cite

Microglial MyD88-dependent signaling influences extracellular matrix development and interneuron maturation in the hippocampus.

Preprint · December 11, 2025 Full text Link to item Cite

Estradiol, via estrogen receptor β signaling, mediates stress-susceptibility in the male brain.

Journal article Molecular psychiatry · October 2025 Dysregulation of normal reward processing via psychological stress contributes to the development of psychiatric disorders. Estrogen is involved in reward processing in females, but this effect has not been well studied in males despite the abundant conver ... Full text Cite

A single-cell genomic atlas for the effects of chronic ethanol exposure in the mouse dorsal striatum.

Journal article Molecular psychiatry · September 2025 Alcohol use disorder (AUD) is characterized by compulsive drinking, which is thought to be mediated by effects of chronic intermittent ethanol exposure on the dorsal striatum, the input nucleus of the basal ganglia. Despite significant efforts to understan ... Full text Cite

Alcohol potentiates multiple GABAergic inputs to dorsal striatum fast-spiking interneurons.

Journal article Neuropharmacology · July 2023 Parvalbumin-expressing dorsal striatal fast-spiking interneurons, comprising ∼1% of the total dorsal striatal neuronal population, are necessary for the expression of compulsive-like ethanol consumption mice. Fast-spiking interneurons are driven to fire by ... Full text Cite

Compulsive alcohol consumption is regulated by dorsal striatum fast-spiking interneurons.

Journal article Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · January 2021 Compulsive alcohol consumption is a core, treatment-resistant feature of alcohol use disorder. The dorsomedial and dorsolateral striatum support goal-directed and habitual action strategies, respectively. How ethanol targets dorsolateral striatum to drive ... Full text Cite

TrkB-dependent disinhibition of the nucleus accumbens is enhanced by ethanol.

Journal article Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · May 2019 The nucleus accumbens is a critical integration center for reward-related circuitry and is comprised primarily of medium spiny projection neurons. The dynamic balance of excitation and inhibition onto medium spiny neurons determines the output of this stru ... Full text Cite

Ketamine Corrects Stress-Induced Cognitive Dysfunction through JAK2/STAT3 Signaling in the Orbitofrontal Cortex.

Journal article Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · May 2017 Deficits in cognitive flexibility are prominent in stress-related psychiatric disorders, including depression. Ketamine has rapid antidepressant efficacy, but it is unknown if ketamine improves cognitive symptoms. In rats, 2 weeks chronic intermittent cold ... Full text Cite