Michael P. Vitek
Adjunct Associate Professor in Neurology
The overall interest of my laboratory is to identify the underlying
causes of neurodegenerative diseases such as Alzheimer's disease. Once causes or experimental endpoints are determined, then strategies to find chemicals which can ameliorate pathophysiological events can be devised. In general, we are working to create transgenic animals and validate them as models of human disease.
Our specific approach has been to study the function of
apolipoprotein-E (apoE) which Roses and colleagues found to a susceptibility factor for the presence of AD. Currently, our data are pointing to a relationship between apoE and oxidative stress where apoE appears to modulate nitric oxide production in a species specific manner. To further test this idea, we have created transgenic mice expressing the entire human NOS2 gene which will now be tested in various models of neurodegeneration and inflammation. Similarly, we are developing transgenic animals which express the human TAU gene. When properly stressed, these TAU-transgenic animals may display the neurofibrillary tangle pathology which is associated with neurodegeneration in a wide variety of neurological diseases.
If our transgenic animals prove to be validated models of human
disease, then the process to screen for chemicals which might alter the disease outcome in those models can begin in earnest. Should compounds be identified, then the various phases of clinical trials may procede.
At present, my community service includes participation on the
Alzheimer's Association Medical and Scientific Advisory Board and on the Neurological Sciences III Study Section for the National Institutes of Health extramural research program. I have previously served in a similar capacity for the American Health Assistance Foundation and the Long Island Alzheimer's Foundation. I have also had the pleasure to serve as a scientific consultant for various biotechnology companies.
Keywords: Neurodegeneration, Alzheimer's, Transgenic, Animal Models, Amyloid, Apolipoprotein-E, Molecular Biology, Biochemistry
causes of neurodegenerative diseases such as Alzheimer's disease. Once causes or experimental endpoints are determined, then strategies to find chemicals which can ameliorate pathophysiological events can be devised. In general, we are working to create transgenic animals and validate them as models of human disease.
Our specific approach has been to study the function of
apolipoprotein-E (apoE) which Roses and colleagues found to a susceptibility factor for the presence of AD. Currently, our data are pointing to a relationship between apoE and oxidative stress where apoE appears to modulate nitric oxide production in a species specific manner. To further test this idea, we have created transgenic mice expressing the entire human NOS2 gene which will now be tested in various models of neurodegeneration and inflammation. Similarly, we are developing transgenic animals which express the human TAU gene. When properly stressed, these TAU-transgenic animals may display the neurofibrillary tangle pathology which is associated with neurodegeneration in a wide variety of neurological diseases.
If our transgenic animals prove to be validated models of human
disease, then the process to screen for chemicals which might alter the disease outcome in those models can begin in earnest. Should compounds be identified, then the various phases of clinical trials may procede.
At present, my community service includes participation on the
Alzheimer's Association Medical and Scientific Advisory Board and on the Neurological Sciences III Study Section for the National Institutes of Health extramural research program. I have previously served in a similar capacity for the American Health Assistance Foundation and the Long Island Alzheimer's Foundation. I have also had the pleasure to serve as a scientific consultant for various biotechnology companies.
Keywords: Neurodegeneration, Alzheimer's, Transgenic, Animal Models, Amyloid, Apolipoprotein-E, Molecular Biology, Biochemistry
Current Appointments & Affiliations
- Adjunct Associate Professor in Neurology, Neurology, Behavioral Neurology, Neurology 2015
Contact Information
- 201D Bryan Res Bldg, Durham, NC 27710
- Duke Box 2900, Durham, NC 27710
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michael.vitek@duke.edu
(919) 684-0055
- Background
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Education, Training, & Certifications
- Ph.D., Dartmouth College 1983
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Previous Appointments & Affiliations
- Associate Professor in Neurology, Neurology, Behavioral Neurology, Neurology 2013 - 2015
- Associate Research Professor in Neurobiology, Neurobiology, Basic Science Departments 2001 - 2013
- Associate Professor in Medicine, Neurology, Clinical Science Departments 2006 - 2013
- Associate Research Professor in Medicine, Neurology, Clinical Science Departments 1999 - 2006
- Assistant Research Professor of Medicine, part-time, Neurology, Clinical Science Departments 1997 - 1998
- Visiting Associate in the Department of Medicine, Neurology, Clinical Science Departments 1995 - 1997
- Research
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Selected Grants
- A Mouse Model of Inflammation in Alzheimer's Disease awarded by National Institutes of Health 2009 - 2014
- The amyloid cascade in a novel mouse model of Alzheimer's disease awarded by National Institutes of Health 2009 - 2014
- Immune Responsiveness, APOE/Gender in Neurodegeneration awarded by National Institutes of Health 2004 - 2009
- Regulation of neuronal NO by apolipoprotein E awarded by National Institutes of Health 2002 - 2007
- Triple transgenic model of Alzheimer's Disease awarded by National Institutes of Health 2002 - 2007
- Regulation of microglial activation awarded by National Institutes of Health 2001 - 2005
- Animal Model Of Alzheimer'S Disease Pathology awarded by National Institutes of Health 1998 - 2001
- Animal model of Alzheimers Disease Pathology awarded by National Institutes of Health 1998 - 2001
- Humanized Animal Model Of Oxyradical Production awarded by National Institutes of Health 1998 - 1999
- Advanced Glycosylation Endproducts And Ad Amyloidosis awarded by National Institutes of Health 1995 - 1998
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Oriá, Reinaldo B., Raul S. Freitas, Cássia R. Roque, José Carlos R. Nascimento, Ana Paula Silva, João O. Malva, Richard L. Guerrant, and Michael P. Vitek. “ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers.” Pharmaceutics 15, no. 4 (March 28, 2023). https://doi.org/10.3390/pharmaceutics15041086.Full Text Link to Item
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Galiger, Celimene, Meike Dahlhaus, Michael Peter Vitek, Klaus-Michael Debatin, and Christian Beltinger. “PPP2CA Is a Novel Therapeutic Target in Neuroblastoma Cells That Can Be Activated by the SET Inhibitor OP449.” Front Oncol 12 (2022): 744984. https://doi.org/10.3389/fonc.2022.744984.Full Text Link to Item
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Swenson-Fields, Katherine I., Christopher J. Ward, Micaila E. Lopez, Shaneann Fross, Anna L. Heimes Dillon, James D. Meisenheimer, Adib J. Rabbani, et al. “Caspase-1 and the inflammasome promote polycystic kidney disease progression.” Front Mol Biosci 9 (2022): 971219. https://doi.org/10.3389/fmolb.2022.971219.Full Text Open Access Copy Link to Item
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Wang, Bo, Feng-Wan Zhang, Wei-Xiao Wang, Yan-Yan Zhao, Su-Yue Sun, Jin-Hong Yu, Michael P. Vitek, et al. “Apolipoprotein E mimetic peptide COG1410 combats pandrug-resistant Acinetobacter baumannii.” Front Microbiol 13 (2022): 934765. https://doi.org/10.3389/fmicb.2022.934765.Full Text Link to Item
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York, Audra, Angela Everhart, Michael P. Vitek, Kirby W. Gottschalk, and Carol A. Colton. “Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease.” Asn Neuro 13 (2021): 17590914211019444. https://doi.org/10.1177/17590914211019443.Full Text Link to Item
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Goto, Renata Nishida, Lays Martin Sobral, Karina Stringhetta-Padovani, Cristiana B. Garcia, Gabriel da Silva, Michael P. Vitek, and Andreia Machado Leopoldino. “Synergic effect of OP449 and FTY720 on oral squamous cell carcinoma.” Eur J Pharmacol 882 (September 5, 2020): 173268. https://doi.org/10.1016/j.ejphar.2020.173268.Full Text Link to Item
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Vitek, Michael P., Joseph A. Araujo, Michael Fossel, Barry D. Greenberg, Gareth R. Howell, Stacey J Sukoff Rizzo, Nicholas T. Seyfried, et al. “Translational animal models for Alzheimer's disease: An Alzheimer's Association Business Consortium Think Tank.” Alzheimers Dement (N Y) 6, no. 1 (2020): e12114. https://doi.org/10.1002/trc2.12114.Full Text Open Access Copy Link to Item
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Pessoa, T., I. Carneiro, P. Aguiar, L. Vieira, M. Vitek, R. Guerrant, R. Oria, and J. Abreu Junior. “WNT / β-catenin pathway in recovering IEC-6 intestinal cells after 5-FU induced injury and treatment with mimetic peptide APOE COG133.” Ann Oncol 30 Suppl 4 (July 2019): iv102. https://doi.org/10.1093/annonc/mdz155.371.Full Text Link to Item
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Pessoa, T., I. Carneiro, P. Aguiar, L. Vieira, R. Guerrant, M. Vitek, J. Abreu Junior, and R. Oria. “Evaluation of the mimetic peptide APOE COG1410 in the viability, migration, and apoptosis of the intestinal cells IEC-18 after injuries by 5-FU.” Ann Oncol 30 Suppl 4 (July 2019): iv31. https://doi.org/10.1093/annonc/mdz155.112.Full Text Link to Item
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Pang, Jinwei, Jianhua Peng, Nathanael Matei, Ping Yang, Li Kuai, Yue Wu, Ligang Chen, et al. “Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice.” Transl Stroke Res 9, no. 6 (December 2018): 654–68. https://doi.org/10.1007/s12975-018-0665-4.Full Text Link to Item
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Enjoji, Shuhei, Ryotaro Yabe, Shunya Tsuji, Kazuhiro Yoshimura, Hideyoshi Kawasaki, Masashi Sakurai, Yusuke Sakai, et al. “Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis.” Mol Cancer Res 16, no. 3 (March 2018): 554–63. https://doi.org/10.1158/1541-7786.MCR-17-0393.Full Text Link to Item
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Li, Xinshen, Jianhua Peng, Jinwei Pang, Yue Wu, Xueping Huang, Yong Li, Jian Zhou, et al. “Apolipoprotein E-Mimetic Peptide COG1410 Promotes Autophagy by Phosphorylating GSK-3β in Early Brain Injury Following Experimental Subarachnoid Hemorrhage.” Front Neurosci 12 (2018): 127. https://doi.org/10.3389/fnins.2018.00127.Full Text Link to Item
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Shlomai, Gadi, Zara Zelenko, Irini Markella Antoniou, Marilyn Stasinopoulos, Aviva Tobin-Hess, Michael P. Vitek, Derek LeRoith, and Emily Jane Gallagher. “OP449 inhibits breast cancer growth without adverse metabolic effects.” Endocr Relat Cancer 24, no. 10 (October 2017): 519–29. https://doi.org/10.1530/ERC-17-0077.Full Text Link to Item
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Pang, Jinwei, Yitian Chen, Li Kuai, Ping Yang, Jianhua Peng, Yue Wu, Yue Chen, et al. “Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.” Transl Stroke Res 8, no. 3 (June 2017): 257–72. https://doi.org/10.1007/s12975-016-0507-1.Full Text Link to Item
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Ross, E. A., A. J. Naylor, J. D. O’Neil, T. Crowley, M. L. Ridley, J. Crowe, T. Smallie, et al. “Treatment of inflammatory arthritis via targeting of tristetraprolin, a master regulator of pro-inflammatory gene expression.” Ann Rheum Dis 76, no. 3 (March 2017): 612–19. https://doi.org/10.1136/annrheumdis-2016-209424.Full Text Link to Item
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Qin, Xinghu, Hong You, Fang Cao, Yue Wu, Jianhua Peng, Jinwei Pang, Hong Xu, et al. “Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood-Brain Barrier Disruption after Controlled Cortical Impact in Mice: An 18F-Fluorodeoxyglucose PET/CT Study.” J Neurotrauma 34, no. 4 (February 15, 2017): 943–51. https://doi.org/10.1089/neu.2016.4485.Full Text Link to Item
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Richard, Nameeta P., Raffaella Pippa, Megan M. Cleary, Alka Puri, Deanne Tibbitts, Shawn Mahmood, Dale J. Christensen, et al. “Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.” Oncotarget 7, no. 51 (December 20, 2016): 84214–27. https://doi.org/10.18632/oncotarget.12394.Full Text Link to Item
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Pang, Jinwei, Yue Wu, Jianhua Peng, Ping Yang, Li Kuai, Xinghu Qin, Fang Cao, et al. “Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity.” Oncotarget 7, no. 35 (August 30, 2016): 56030–44. https://doi.org/10.18632/oncotarget.10821.Full Text Link to Item
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Wu, Yue, Jinwei Pang, Jianhua Peng, Fang Cao, Michael P. Vitek, Fengqiao Li, Yong Jiang, and Xiaochuan Sun. “An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage.” Neurosci Lett 627 (August 3, 2016): 92–99. https://doi.org/10.1016/j.neulet.2016.05.058.Full Text Link to Item
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Cao, Fang, Yong Jiang, Yue Wu, Jianjun Zhong, Jieshi Liu, Xinghu Qin, Ligang Chen, et al. “Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury.” J Neurotrauma 33, no. 2 (January 15, 2016): 175–82. https://doi.org/10.1089/neu.2015.3887.Full Text Link to Item
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Vitek, Michael P. “Abstract A092: Surpassing the emerging immune-checkpoint inhibitor market.” Cancer Immunology Research 4, no. 1_Supplement (January 1, 2016): A092–A092. https://doi.org/10.1158/2326-6074.cricimteatiaacr15-a092.Full Text Open Access Copy
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Hu, Xiaoyong, Consuelo Garcia, Ladan Fazli, Martin Gleave, Michael P. Vitek, Marilyn Jansen, Dale Christensen, and David J. Mulholland. “Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.” Sci Rep 5 (November 13, 2015): 15182. https://doi.org/10.1038/srep15182.Full Text Open Access Copy Link to Item
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Enjoji, Shuhei, Ryotaro Yabe, Nobuyuki Fujiwara, Shunya Tsuji, Michael P. Vitek, Takuya Mizuno, Takayuki Nakagawa, Tatsuya Usui, Takashi Ohama, and Koichi Sato. “The therapeutic effects of SET/I2PP2A inhibitors on canine melanoma.” J Vet Med Sci 77, no. 11 (November 2015): 1451–56. https://doi.org/10.1292/jvms.15-0193.Full Text Link to Item
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Trakhtenberg, Ephraim F., Melina I. Morkin, Karan H. Patel, Stephanie G. Fernandez, Alan Sang, Peter Shaw, Xiongfei Liu, et al. “The N-terminal Set-β Protein Isoform Induces Neuronal Death.” J Biol Chem 290, no. 21 (May 22, 2015): 13417–26. https://doi.org/10.1074/jbc.M114.633883.Full Text Link to Item
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Kan, Matthew J., Jennifer E. Lee, Joan G. Wilson, Angela L. Everhart, Candice M. Brown, Andrew N. Hoofnagle, Marilyn Jansen, Michael P. Vitek, Michael D. Gunn, and Carol A. Colton. “Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.” J Neurosci 35, no. 15 (April 15, 2015): 5969–82. https://doi.org/10.1523/JNEUROSCI.4668-14.2015.Full Text Link to Item
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Hoos, Michael D., Michael P. Vitek, Lisa A. Ridnour, Joan Wilson, Marilyn Jansen, Angela Everhart, David A. Wink, and Carol A. Colton. “The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment.” Mol Neurodegener 9 (November 17, 2014): 50. https://doi.org/10.1186/1750-1326-9-50.Full Text Link to Item
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Pippa, R., A. Dominguez, D. J. Christensen, I. Moreno-Miralles, M. J. Blanco-Prieto, M. P. Vitek, and M. D. Odero. “Effect of FTY720 on the SET-PP2A complex in acute myeloid leukemia; SET binding drugs have antagonistic activity.” Leukemia 28, no. 9 (September 2014): 1915–18. https://doi.org/10.1038/leu.2014.141.Full Text Link to Item
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Colton, Carol A., Joan G. Wilson, Angela Everhart, Donna M. Wilcock, Jukka Puoliväli, Taneli Heikkinen, Juho Oksman, et al. “mNos2 deletion and human NOS2 replacement in Alzheimer disease models.” J Neuropathol Exp Neurol 73, no. 8 (August 2014): 752–69. https://doi.org/10.1097/NEN.0000000000000094.Full Text Link to Item
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Wang, Ruihua, Jun Hong, Miaomiao Lu, Jessica E. Neil, Michael P. Vitek, Xiaozhi Liu, David S. Warner, Fengqiao Li, and Huaxin Sheng. “ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury.” J Neurosci Res 92, no. 7 (July 2014): 884–92. https://doi.org/10.1002/jnr.23371.Full Text Open Access Copy Link to Item
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Farrell, Amy S., Brittany Allen-Petersen, Colin J. Daniel, Xiaoyan Wang, Zhiping Wang, Sarah Rodriguez, Soren Impey, et al. “Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer.” Mol Cancer Res 12, no. 6 (June 2014): 924–39. https://doi.org/10.1158/1541-7786.MCR-13-0542.Full Text Link to Item
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Agarwal, Anupriya, Ryan J. MacKenzie, Raffaella Pippa, Christopher A. Eide, Jessica Oddo, Jeffrey W. Tyner, Rosalie Sears, et al. “Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia.” Clin Cancer Res 20, no. 8 (April 15, 2014): 2092–2103. https://doi.org/10.1158/1078-0432.CCR-13-2575.Full Text Link to Item
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Latypova, E. M., S. I. Timoshenko, G. A. Kislik, M. P. Vitek, A. L. Schwarzman, and S. V. Sarantseva. “The study of the neuroprotective activity of the apolipoprotein e peptide mimetic Cog1410 in transgenic strains of Drosophila melanogaster.” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 8, no. 1 (January 1, 2014): 37–42. https://doi.org/10.1134/S1990750814010107.Full Text
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Azevedo, Orleâncio G. R., David T. Bolick, James K. Roche, Relana F. Pinkerton, Aldo A. M. Lima, Michael P. Vitek, Cirle A. Warren, Reinaldo B. Oriá, and Richard L. Guerrant. “Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.” Plos One 9, no. 2 (2014): e89562. https://doi.org/10.1371/journal.pone.0089562.Full Text Link to Item
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Latypova, E. M., S. I. Timoshenko, G. A. Kislik, M. Vitek, A. L. Shvartsman, and S. V. Sarantseva. “[Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster].” Biomed Khim 60, no. 4 (2014): 515–21. https://doi.org/10.18097/pbmc20146004515.Full Text Link to Item
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Gu, Zhen, Fengqiao Li, Yi Ping Zhang, Lisa B. E. Shields, Xiaoling Hu, Yiyan Zheng, Panpan Yu, et al. “Apolipoprotein E Mimetic Promotes Functional and Histological Recovery in Lysolecithin-Induced Spinal Cord Demyelination in Mice.” J Neurol Neurophysiol 2014, no. Suppl 12 (April 2013): 10. https://doi.org/10.4172/2155-9562.S12-010.Full Text Open Access Copy Link to Item
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Wang, Haichen, Lauren G. Anderson, Christopher D. Lascola, Michael L. James, Talaignair N. Venkatraman, Ellen R. Bennett, Shawn K. Acheson, Michael P. Vitek, and Daniel T. Laskowitz. “ApolipoproteinE mimetic peptides improve outcome after focal ischemia.” Exp Neurol 241 (March 2013): 67–74. https://doi.org/10.1016/j.expneurol.2012.11.027.Full Text Link to Item
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Fujiwara, Nobuyuki, Hideyoshi Kawasaki, Ryotaro Yabe, Dale J. Christensen, Michael P. Vitek, Takuya Mizuno, Koichi Sato, and Takashi Ohama. “A potential therapeutic application of SET/I2PP2A inhibitor OP449 for canine T-cell lymphoma.” J Vet Med Sci 75, no. 3 (2013): 349–54. https://doi.org/10.1292/jvms.12-0366.Full Text Link to Item
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Ghosal, Kaushik, Andrea Stathopoulos, Dustin Thomas, David Phenis, Michael P. Vitek, and Sanjay W. Pimplikar. “The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features.” Neurodegener Dis 12, no. 1 (2013): 51–58. https://doi.org/10.1159/000341299.Full Text Link to Item
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Madenspacher, Jennifer H., Kathleen M. Azzam, Wanghua Gong, Kymberly M. Gowdy, Michael P. Vitek, Daniel T. Laskowitz, Alan T. Remaley, Ji Ming Wang, and Michael B. Fessler. “Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity.” J Biol Chem 287, no. 52 (December 21, 2012): 43730–40. https://doi.org/10.1074/jbc.M112.377192.Full Text Link to Item
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Ridnour, Lisa A., Sneha Dhanapal, Michael Hoos, Joan Wilson, Jennifer Lee, Robert Y. S. Cheng, Ernst E. Brueggemann, et al. “Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1.” J Neurochem 123, no. 5 (December 2012): 736–49. https://doi.org/10.1111/jnc.12028.Full Text Link to Item
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Azevedo, Orleâncio Gomes R., Renato André C. Oliveira, Bruna Castro Oliveira, Snjezana Zaja-Milatovic, Celina Viana Araújo, Deysi Viviana T. Wong, Tiê Bezerra Costa, et al. “Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis.” Bmc Gastroenterol 12 (July 13, 2012): 35. https://doi.org/10.1186/1471-230X-12-35.Full Text Link to Item
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Laskowitz, Daniel T., Beilei Lei, Hana N. Dawson, Haichen Wang, Steven T. Bellows, Dale J. Christensen, Michael P. Vitek, and Michael L. James. “The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage.” Neurocrit Care 16, no. 2 (April 2012): 316–26. https://doi.org/10.1007/s12028-011-9641-5.Full Text Link to Item
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Lei, Beilei, Brian Mace, Steven T. Bellows, Patrick M. Sullivan, Michael P. Vitek, Daniel T. Laskowitz, and Michael L. James. “Interaction between sex and apolipoprotein e genetic background in a murine model of intracerebral hemorrhage.” Transl Stroke Res 3, no. 1 (March 2012): 94–101. https://doi.org/10.1007/s12975-012-0176-7.Full Text Link to Item
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Schwarzman, A. L., S. V. Sarantseva, and M. P. Vitek. “The potential role of presenilin 1 in regulation of synaptic function.” Cell and Tissue Biology 6, no. 1 (February 1, 2012): 60–68. https://doi.org/10.1134/S1990519X12010117.Full Text
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Vitek, M. P., D. J. Christensen, D. Wilcock, J. Davis, W. E. Van Nostrand, F. Q. Li, and C. A. Colton. “APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics.” Neurodegener Dis 10, no. 1–4 (2012): 122–26. https://doi.org/10.1159/000334914.Full Text Link to Item
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Xu, Feng, Michael P. Vitek, Carol A. Colton, Mary Lou Previti, Judianne Davis, and William E. Van Nostrand. “Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice.” J Alzheimers Dis 31, no. 2 (2012): 359–69. https://doi.org/10.3233/JAD-2012-120421.Full Text Link to Item
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Yao, Xianglan, Michael P. Vitek, Alan T. Remaley, and Stewart J. Levine. “Apolipoprotein mimetic peptides: a new approach for the treatment of asthma.” Front Pharmacol 3 (2012): 37. https://doi.org/10.3389/fphar.2012.00037.Full Text Link to Item
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Switzer, Christopher H., Sharon A. Glynn, Lisa A. Ridnour, Robert Y-S Cheng, Michael P. Vitek, Stefan Ambs, and David A. Wink. “Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer.” Trends Pharmacol Sci 32, no. 11 (November 2011): 644–51. https://doi.org/10.1016/j.tips.2011.07.001.Full Text Link to Item
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Christensen, Dale J., Youwei Chen, Jessica Oddo, Karen M. Matta, Jessica Neil, Evan D. Davis, Alicia D. Volkheimer, et al. “SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target.” Blood 118, no. 15 (October 13, 2011): 4150–58. https://doi.org/10.1182/blood-2011-04-351072.Full Text Link to Item
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Switzer, C. H., R. Y. S. Cheng, T. M. Vitek, D. J. Christensen, D. A. Wink, and M. P. Vitek. “Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy.” Oncogene 30, no. 22 (June 2, 2011): 2504–13. https://doi.org/10.1038/onc.2010.622.Full Text Link to Item
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Wink, David A., Harry B. Hines, Robert Y. S. Cheng, Christopher H. Switzer, Wilmarie Flores-Santana, Michael P. Vitek, Lisa A. Ridnour, and Carol A. Colton. “Nitric oxide and redox mechanisms in the immune response.” J Leukoc Biol 89, no. 6 (June 2011): 873–91. https://doi.org/10.1189/jlb.1010550.Full Text Link to Item
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Christensen, Dale J., Jessica Oddo, Amy S. Farrell, Mahnaz J. Janghorban, Michael P. Vitek, and Rosalie C. Sears. “Abstract 615: PP2A activation as a strategy for treatment of breast cancer.” Cancer Research 71, no. 8_Supplement (April 15, 2011): 615–615. https://doi.org/10.1158/1538-7445.am2011-615.Full Text
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Christensen, Dale J., Nobutaka Ohkubo, Jessica Oddo, Michael J. Van Kanegan, Jessica Neil, Fengqiao Li, Carol A. Colton, and Michael P. Vitek. “Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.” J Immunol 186, no. 4 (February 15, 2011): 2535–42. https://doi.org/10.4049/jimmunol.1002847.Full Text Link to Item
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Singh, Kshipra, Rupesh Chaturvedi, Daniel P. Barry, Lori A. Coburn, Mohammad Asim, Nuruddeen D. Lewis, M Blanca Piazuelo, M Kay Washington, Michael P. Vitek, and Keith T. Wilson. “The apolipoprotein E-mimetic peptide COG112 inhibits NF-kappaB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis.” J Biol Chem 286, no. 5 (February 4, 2011): 3839–50. https://doi.org/10.1074/jbc.M110.176719.Full Text Link to Item
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Shipton, Olivia A., Julie R. Leitz, Jenny Dworzak, Christine E. J. Acton, Elizabeth M. Tunbridge, Franziska Denk, Hana N. Dawson, et al. “Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation.” J Neurosci 31, no. 5 (February 2, 2011): 1688–92. https://doi.org/10.1523/JNEUROSCI.2610-10.2011.Full Text Link to Item
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Shvartsman, A. L., S. V. Sarantseva, and M. P. Vitek. “[Potential role of presenilin 1 in regulation of synaptic function].” Tsitologiia 53, no. 12 (2011): 959–67.Link to Item
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Kaufman, Nicholas A., Jason E. Beare, Arlene A. Tan, Michael P. Vitek, Suzanne E. McKenna, and Michael R. Hoane. “COG1410, an apolipoprotein E-based peptide, improves cognitive performance and reduces cortical loss following moderate fluid percussion injury in the rat.” Behav Brain Res 214, no. 2 (December 25, 2010): 395–401. https://doi.org/10.1016/j.bbr.2010.06.017.Full Text Link to Item
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Schwarzman, A. L., S. V. Sarantseva, O. L. Runova, E. I. Talalaeva, and M. P. Vitek. “Familial Alzheimer's disease mutations in the presenilin 1 gene reduce cell-cell adhesion in transfected fibroblasts.” Biophysics 55, no. 5 (December 1, 2010): 760–64. https://doi.org/10.1134/S0006350910050131.Full Text
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Laskowitz, Daniel T., Pingping Song, Haichen Wang, Brian Mace, Patrick M. Sullivan, Michael P. Vitek, and Hana N. Dawson. “Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic.” J Neurotrauma 27, no. 11 (November 2010): 1983–95. https://doi.org/10.1089/neu.2010.1396.Full Text Open Access Copy Link to Item
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Dawson, H. N., V. Cantillana, M. Jansen, H. Wang, M. P. Vitek, D. M. Wilcock, J. R. Lynch, and D. T. Laskowitz. “Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease.” Neuroscience 169, no. 1 (August 11, 2010): 516–31. https://doi.org/10.1016/j.neuroscience.2010.04.037.Full Text Link to Item
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Li, Feng-Qiao, Kenneth A. Fowler, Jessica E. Neil, Carol A. Colton, and Michael P. Vitek. “An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury.” J Pharmacol Exp Ther 334, no. 1 (July 2010): 106–15. https://doi.org/10.1124/jpet.110.167882.Full Text Link to Item
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Barreda, Elena Gómez de, Hana N. Dawson, Michel P. Vitek, and Jesús Avila. “Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression.” Febs Lett 584, no. 11 (June 3, 2010): 2265–70. https://doi.org/10.1016/j.febslet.2010.03.032.Full Text Link to Item
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Gómez de Barreda, Elena, Mar Pérez, Pilar Gómez Ramos, Javier de Cristobal, Patricia Martín-Maestro, Asunción Morán, Hana N. Dawson, et al. “Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits.” Neurobiol Dis 37, no. 3 (March 2010): 622–29. https://doi.org/10.1016/j.nbd.2009.11.017.Full Text Link to Item
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Wilcock, D. M., N. Gharkholonarehe, W. E. Van Nostrand, J. Davis, M. P. Vitek, and C. A. Colton. “Amyloid reduction by amyloid-β vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease (The Journal of Neuroscience (2009) (7957-7965)).” Journal of Neuroscience 30, no. 3 (January 20, 2010): 1197–98.
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Shvartsman, A. L., S. V. Sarantseva, O. L. Runova, E. I. Talalaeva, and M. P. Vitek. “[Familial Alzheimer's disease mutations in the presenilin 1 gene reduce cell-cell adhesion in transfected fibroblasts].” Biofizika 55, no. 5 (2010): 862–67.Link to Item
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Sarantseva, Svetlana, Svetlana Timoshenko, Olga Bolshakova, Eugenia Karaseva, Dmitry Rodin, Alexander L. Schwarzman, and Michael P. Vitek. “Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic Drosophila model of Alzheimer's disease.” Plos One 4, no. 12 (December 7, 2009): e8191. https://doi.org/10.1371/journal.pone.0008191.Full Text Link to Item
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Dunys, Julie, Jean Sevalle, Emilie Giaime, Raphaëlle Pardossi-Piquard, Michael P. Vitek, Paul Renbaum, Ephrat Levy-Lahad, et al. “p53-dependent control of transactivation of the Pen2 promoter by presenilins.” J Cell Sci 122, no. Pt 21 (November 1, 2009): 4003–8. https://doi.org/10.1242/jcs.051169.Full Text Link to Item
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Switzer, C. H., L. A. Ridnour, R. Y. S. Cheng, A. Sparatore, P. Del Soldato, T. W. Moody, M. P. Vitek, D. D. Roberts, and D. A. Wink. “Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity.” Oncogene 28, no. 43 (October 29, 2009): 3837–46. https://doi.org/10.1038/onc.2009.244.Full Text Link to Item
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Fuster-Matanzo, Almudena, Elena Gómez de Barreda, Hana N. Dawson, Michael P. Vitek, Jesús Avila, and Félix Hernández. “Function of tau protein in adult newborn neurons.” Febs Lett 583, no. 18 (September 17, 2009): 3063–68. https://doi.org/10.1016/j.febslet.2009.08.017.Full Text Link to Item
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Vitek, Michael P., Candice M. Brown, and Carol A. Colton. “APOE genotype-specific differences in the innate immune response.” Neurobiol Aging 30, no. 9 (September 2009): 1350–60. https://doi.org/10.1016/j.neurobiolaging.2007.11.014.Full Text Link to Item
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Wilcock, Donna M., Nastaran Gharkholonarehe, William E. Van Nostrand, Judianne Davis, Michael P. Vitek, and Carol A. Colton. “Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.” J Neurosci 29, no. 25 (June 24, 2009): 7957–65. https://doi.org/10.1523/JNEUROSCI.1339-09.2009.Full Text Link to Item
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Sarantseva, S. V., O. I. Bolshakova, S. I. Timoshenko, A. A. Kolobov, M. P. Vitek, and A. L. Schwarzman. “Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in Drosophila melanogaster.” Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 3, no. 2 (June 1, 2009): 149–55. https://doi.org/10.1134/S199075080902005X.Full Text
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Perez, Mar, Ismael Santa-Maria, Elena Gomez de Barreda, Xiongwei Zhu, Raquel Cuadros, Jose Roman Cabrero, Francisco Sanchez-Madrid, et al. “Tau--an inhibitor of deacetylase HDAC6 function.” J Neurochem 109, no. 6 (June 2009): 1756–66. https://doi.org/10.1111/j.1471-4159.2009.06102.x.Full Text Link to Item
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Wilcock, D. M., M. P. Vitek, and C. A. Colton. “Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease.” Neuroscience 159, no. 3 (March 31, 2009): 1055–69. https://doi.org/10.1016/j.neuroscience.2009.01.023.Full Text Link to Item
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Tukhovskaya, Elena A., Alexey Yu Yukin, Oksana N. Khokhlova, Arkady N. Murashev, and Michael P. Vitek. “COG1410, a novel apolipoprotein-E mimetic, improves functional and morphological recovery in a rat model of focal brain ischemia.” J Neurosci Res 87, no. 3 (February 15, 2009): 677–82. https://doi.org/10.1002/jnr.21874.Full Text Link to Item
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James, Michael L., Patrick M. Sullivan, Christopher D. Lascola, Michael P. Vitek, and Daniel T. Laskowitz. “Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage.” Stroke 40, no. 2 (February 2009): 632–39. https://doi.org/10.1161/STROKEAHA.108.530402.Full Text Link to Item
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Sarantseva, S. V., O. I. Bolshakova, S. I. Timoshenko, D. I. Rodin, M. Vitek, and A. L. Schwarzman. “Studying the pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: Human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin.” Russian Journal of Genetics 45, no. 1 (January 1, 2009): 105–12. https://doi.org/10.1134/S1022795409010153.Full Text
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Sarantseva, S., S. Timoshenko, O. Bolshakova, E. Karaseva, D. Rodin, A. L. Schwarzman, and M. P. Vitek. “Apolipoprotein E-mimetics inhibit neurodegeneration and restore cognitive functions in a transgenic drosophila model of Alzheimer's disease.” Plos One 4, no. 12 (2009). https://doi.org/10.1371/journal.pone.0008191.Full Text
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Hoane, Michael R., Nicholas Kaufman, Michael P. Vitek, and Suzanne E. McKenna. “COG1410 improves cognitive performance and reduces cortical neuronal loss in the traumatically injured brain.” J Neurotrauma 26, no. 1 (January 2009): 121–29. https://doi.org/10.1089/neu.2008.0565.Full Text Link to Item
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Sarantseva, S. V., O. I. Bol’shakova, S. I. Timoshenko, A. A. Kolobov, M. P. Vitek, and A. L. Shvartsman. “[Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in Drosophila].” Biomed Khim 55, no. 1 (2009): 41–49.Link to Item
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Sarantseva, S. V., O. I. Bol’shakova, S. I. Timoshenko, D. I. Rodin, M. P. Vitek, and A. L. Shvartsman. “[Studying pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin].” Genetika 45, no. 1 (January 2009): 119–26.Link to Item
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Wang, H., D. J. Christensen, M. P. Vitek, P. M. Sullivan, and D. T. Laskowitz. “APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy.” Anaesth Intensive Care 37, no. 1 (January 2009): 38–45. https://doi.org/10.1177/0310057X0903700111.Full Text Link to Item
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Shwartsman, A. L., S. V. Sarantseva, K. V. Solovyov, O. L. Runova, E. I. Talalaeva, and M. P. Vitek. “Degeneration of growth cones in a culture of embryonic neurons of mouse with presenilin 1 knockout.” Biophysics 53, no. 6 (December 1, 2008): 550–54. https://doi.org/10.1134/S0006350908060158.Full Text
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Brown, Candice M., Emily Choi, Qing Xu, Michael P. Vitek, and Carol A. Colton. “The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol.” Neurobiol Aging 29, no. 12 (December 2008): 1783–94. https://doi.org/10.1016/j.neurobiolaging.2007.04.018.Full Text Link to Item
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Colton, Carol A., Donna M. Wilcock, David A. Wink, Judianne Davis, William E. Van Nostrand, and Michael P. Vitek. “The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.” J Alzheimers Dis 15, no. 4 (December 2008): 571–87. https://doi.org/10.3233/jad-2008-15405.Full Text Link to Item
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Christensen, Dale J., Karen M. Bond, Alicia D. Volkheimer, Jessica Oddo, Youwei Chen, Jon P. Gockerrnan, Joseph O. Moore, et al. “Apolipoprotein E-Mimetic Therapeutic Peptides Mediate CLL Cell Cytotoxicity.” Blood 112, no. 11 (November 16, 2008): 140–140.Link to Item
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Singh, Kshipra, Rupesh Chaturvedi, Mohammad Asim, Daniel P. Barry, Nuruddeen D. Lewis, Michael P. Vitek, and Keith T. Wilson. “The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation.” J Biol Chem 283, no. 24 (June 13, 2008): 16752–61. https://doi.org/10.1074/jbc.M710530200.Full Text Link to Item
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Xu, Feng, Michael P. Vitek, Carol A. Colton, Mary Lou Previti, Nastaran Gharkholonarehe, Judianne Davis, and William E. Van Nostrand. “Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice.” J Neurosci 28, no. 20 (May 14, 2008): 5312–20. https://doi.org/10.1523/JNEUROSCI.1042-08.2008.Full Text Link to Item
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Stopa, Edward G., Parag Butala, Stephen Salloway, Conrad E. Johanson, Liliana Gonzalez, Rosemarie Tavares, Virginia Hovanesian, Christine M. Hulette, Michael P. Vitek, and Ronald A. Cohen. “Cerebral cortical arteriolar angiopathy, vascular beta-amyloid, smooth muscle actin, Braak stage, and APOE genotype.” Stroke 39, no. 3 (March 2008): 814–21. https://doi.org/10.1161/STROKEAHA.107.493429.Full Text Link to Item
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Wilcock, Donna M., Matthew R. Lewis, William E. Van Nostrand, Judianne Davis, Mary Lou Previti, Nastaran Gharkholonarehe, Michael P. Vitek, and Carol A. Colton. “Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.” J Neurosci 28, no. 7 (February 13, 2008): 1537–45. https://doi.org/10.1523/JNEUROSCI.5066-07.2008.Full Text Link to Item
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Shvartsman, A. L., S. V. Sarantseva, K. V. Solov’ev, O. L. Runova, E. I. Talalaeva, and M. P. Vitek. “[Degeneration of growth cones in a culture of embryonic neurons of mouse with presenilin 1 gene knockout].” Biofizika 53, no. 6 (2008): 1008–13.Link to Item
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Ridnour, Lisa A., Alisha N. Windhausen, Jeffrey S. Isenberg, Nolan Yeung, Douglas D. Thomas, Michael P. Vitek, David D. Roberts, and David A. Wink. “Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways.” Proc Natl Acad Sci U S A 104, no. 43 (October 23, 2007): 16898–903. https://doi.org/10.1073/pnas.0702761104.Full Text Link to Item
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Ohkubo, Nobutaka, Michael P. Vitek, Atsuyuki Morishima, Yoji Suzuki, Tetsuro Miki, Nobuji Maeda, and Noriaki Mitsuda. “Reelin signals survival through Src-family kinases that inactivate BAD activity.” J Neurochem 103, no. 2 (October 2007): 820–30. https://doi.org/10.1111/j.1471-4159.2007.04804.x.Full Text Link to Item
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Dawson, Hana N., Viviana Cantillana, Liling Chen, and Michael P. Vitek. “The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model.” J Neurosci 27, no. 34 (August 22, 2007): 9155–68. https://doi.org/10.1523/JNEUROSCI.5492-06.2007.Full Text Link to Item
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Laskowitz, Daniel T., and Michael P. Vitek. “Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions.” Pharmacogenomics 8, no. 8 (August 2007): 959–69. https://doi.org/10.2217/14622416.8.8.959.Full Text Link to Item
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Brown, Candice M., Qing Xu, Nobutaka Okhubo, Michael P. Vitek, and Carol A. Colton. “Androgen-mediated immune function is altered by the apolipoprotein E gene.” Endocrinology 148, no. 7 (July 2007): 3383–90. https://doi.org/10.1210/en.2006-1200.Full Text Link to Item
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Hoane, Michael R., Jeremy L. Pierce, Michael A. Holland, Nicholas D. Birky, Tan Dang, Michael P. Vitek, and Suzanne E. McKenna. “The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury.” J Neurotrauma 24, no. 7 (July 2007): 1108–18. https://doi.org/10.1089/neu.2006.0254.Full Text Link to Item
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Laskowitz, Daniel T., Suzanne E. McKenna, Pingping Song, Haichen Wang, Lori Durham, Nolan Yeung, Dale Christensen, and Michael P. Vitek. “COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury.” J Neurotrauma 24, no. 7 (July 2007): 1093–1107. https://doi.org/10.1089/neu.2006.0192.Full Text Link to Item
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Zipser, B. D., C. E. Johanson, L. Gonzalez, T. M. Berzin, R. Tavares, C. M. Hulette, M. P. Vitek, V. Hovanesian, and E. G. Stopa. “Microvascular injury and blood-brain barrier leakage in Alzheimer's disease.” Neurobiol Aging 28, no. 7 (July 2007): 977–86. https://doi.org/10.1016/j.neurobiolaging.2006.05.016.Full Text Link to Item
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Wang, H., L. Durham, H. Dawson, P. Song, D. S. Warner, P. M. Sullivan, M. P. Vitek, and D. T. Laskowitz. “Corrigendum to "an apolipoprotein e-based therapeutic improves outcome and reduces alzheimer's disease pathology following closed head injury: Evidence of pharmacogenomic interaction". [Neuroscience 144 (2007) 1324-1333]{star, open} (DOI:10.1016/j.neuroscience.2006.11.017).” Neuroscience 146, no. 2 (May 11, 2007): 874. https://doi.org/10.1016/j.neuroscience.2007.01.044.Full Text
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Wang, H., L. Durham, H. Dawson, P. Song, D. S. Warner, P. M. Sullivan, M. P. Vitek, and D. T. Laskowitz. “An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction.” Neuroscience 144, no. 4 (February 23, 2007): 1324–33. https://doi.org/10.1016/j.neuroscience.2006.11.017.Full Text Link to Item
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Colton, C. A., M. P. Vitek, D. A. Wink, Q. Xu, V. Cantillana, M. L. Previti, W. E. Van Nostrand, J. B. Weinberg, and H. Dawson. “Erratum: NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease (Proceedings of the National Academy of Sciences of the United States of America (August 22, 2006) 103, 34 (12867-1872) DOI: 10.1073/pnas.0601075103).” Proceedings of the National Academy of Sciences of the United States of America 103, no. 41 (October 10, 2006): 15273. https://doi.org/10.1073/pnas.0607808103.Full Text
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Schwartsman, A. L., S. V. Sarantseva, Y. A. Tatishcheva, O. L. Runova, E. I. Talalaeva, and M. P. Vitek. “Presenilin 1 expression on the cell surface in motile polarized cells.” Biophysics 51, no. 5 (October 1, 2006): 740–43. https://doi.org/10.1134/S0006350906050125.Full Text
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Colton, Carol A., Ryan T. Mott, Hayley Sharpe, Qing Xu, William E. Van Nostrand, and Michael P. Vitek. “Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD.” J Neuroinflammation 3 (September 27, 2006): 27. https://doi.org/10.1186/1742-2094-3-27.Full Text Link to Item
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Mesis, Rachel G., Haichen Wang, Frederick W. Lombard, Robert Yates, Michael P. Vitek, Cecil O. Borel, David S. Warner, and Daniel T. Laskowitz. “Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage.” Neurosurg Focus 21, no. 3 (September 15, 2006): E4. https://doi.org/10.3171/foc.2006.21.3.4.Full Text Link to Item
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Li, Feng-Qiao, Gregory D. Sempowski, Suzanne E. McKenna, Daniel T. Laskowitz, Carol A. Colton, and Michael P. Vitek. “Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis.” J Pharmacol Exp Ther 318, no. 3 (September 2006): 956–65. https://doi.org/10.1124/jpet.106.103671.Full Text Link to Item
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Colton, C. A., M. P. Vitek, D. A. Wink, Q. Xu, V. Cantillana, M. L. Previti, W. E. Van Nostrand, J. B. Weinberg, and H. Dawson. “NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease.” Proc Natl Acad Sci U S A 103, no. 34 (August 22, 2006): 12867–72. https://doi.org/10.1073/pnas.0601075103.Full Text Link to Item
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Jiménez-Mateos, Eva-María, Christian González-Billault, Hana N. Dawson, Michael P. Vitek, and Jesús Avila. “Role of MAP1B in axonal retrograde transport of mitochondria.” Biochem J 397, no. 1 (July 1, 2006): 53–59. https://doi.org/10.1042/BJ20060205.Full Text Link to Item
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Colton, Carol A., and Michael P. Vitek. “NPY and chronic neurodegenerative disease.” Exs, no. 95 (2006): 223–44. https://doi.org/10.1007/3-7643-7417-9_17.Full Text Link to Item
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Gao, Junling, Haichen Wang, Huaxin Sheng, John R. Lynch, David S. Warner, Lori Durham, Michael P. Vitek, and Daniel T. Laskowitz. “A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.” Neurocrit Care 4, no. 1 (2006): 25–31. https://doi.org/10.1385/NCC:4:1:025.Full Text Link to Item
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Laskowitz, D. T., H. Fillit, N. Yeung, K. Toku, and M. P. Vitek. “Apolipoprotein E-derived peptides reduce CNS inflammation: implications for therapy of neurological disease.” Acta Neurol Scand Suppl 185 (2006): 15–20. https://doi.org/10.1111/j.1600-0404.2006.00680.x.Full Text Link to Item
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Shvartsman, A. L., S. V. Sarantseva, Iu A. Tatishcheva, O. L. Runova, E. I. Talalaeva, and M. P. Vitek. “[Expression of presenilin 1 on the cell surface in motile polarized cells].” Biofizika 51, no. 5 (2006): 839–43.Link to Item
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Vitek, Michael P., Candice Brown, Qing Xu, Hana Dawson, Noriaki Mitsuda, and Carol A. Colton. “Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background.” Antioxid Redox Signal 8, no. 5–6 (2006): 893–901. https://doi.org/10.1089/ars.2006.8.893.Full Text Link to Item
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Schwarzman, Alexander L., Maria Tsiper, Luisa Gregori, Dmitry Goldgaber, Janusz Frakowiak, Bozena Mazur-Kolecka, Anastasia Taraskina, Sofia Pchelina, and Michael P. Vitek. “Selection of peptides binding to the amyloid b-protein reveals potential inhibitors of amyloid formation.” Amyloid 12, no. 4 (December 2005): 199–209. https://doi.org/10.1080/13506120500350762.Full Text Link to Item
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Miao, Jianting, Michael P. Vitek, Feng Xu, Mary Lou Previti, Judianne Davis, and William E. Van Nostrand. “Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice.” J Neurosci 25, no. 27 (July 6, 2005): 6271–77. https://doi.org/10.1523/JNEUROSCI.1306-05.2005.Full Text Link to Item
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McAdoo, Jessica D., David S. Warner, Ron N. Goldberg, Michael P. Vitek, Robert Pearlstein, and Daniel T. Laskowitz. “Intrathecal administration of a novel apoE-derived therapeutic peptide improves outcome following perinatal hypoxic-ischemic injury.” Neurosci Lett 381, no. 3 (June 24, 2005): 305–8. https://doi.org/10.1016/j.neulet.2005.02.036.Full Text Link to Item
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Colton, Carol A., Candice M. Brown, and Michael P. Vitek. “Sex steroids, APOE genotype and the innate immune system.” Neurobiol Aging 26, no. 3 (March 2005): 363–72. https://doi.org/10.1016/j.neurobiolaging.2004.08.001.Full Text Link to Item
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Lynch, John R., Haichen Wang, Brian Mace, Stephen Leinenweber, David S. Warner, Ellen R. Bennett, Michael P. Vitek, Suzanne McKenna, and Daniel T. Laskowitz. “A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury.” Exp Neurol 192, no. 1 (March 2005): 109–16. https://doi.org/10.1016/j.expneurol.2004.11.014.Full Text Link to Item
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Colton, C. A., Q. Xu, J. R. Burke, S. Y. Bae, J. K. Wakefield, A. Nair, W. J. Strittmatter, and M. P. Vitek. “Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death.” J Neurosci 24, no. 32 (August 11, 2004): 7118–27. https://doi.org/10.1523/JNEUROSCI.1233-04.2004.Full Text Link to Item
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Rissman, Robert A., Wayne W. Poon, Mathew Blurton-Jones, Salvatore Oddo, Reidun Torp, Michael P. Vitek, Frank M. LaFerla, Troy T. Rohn, and Carl W. Cotman. “Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology.” J Clin Invest 114, no. 1 (July 2004): 121–30. https://doi.org/10.1172/JCI20640.Full Text Link to Item
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Rasmussen, Fred H., Nolan Yeung, Laura Kiefer, Gillian Murphy, Carlos Lopez-Otin, Michael P. Vitek, and Marcia L. Moss. “Use of a multiple-enzyme/multiple-reagent assay system to quantify activity levels in samples containing mixtures of matrix metalloproteinases.” Biochemistry 43, no. 11 (March 23, 2004): 2987–95. https://doi.org/10.1021/bi036063m.Full Text Link to Item
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Schwarzman, Alexander L., Maria Tsiper, Henning Wente, Audrey Wang, Michael P. Vitek, V. Vasiliev, and Dmitry Goldgaber. “Amyloidogenic and anti-amyloidogenic properties of recombinant transthyretin variants.” Amyloid 11, no. 1 (March 2004): 1–9. https://doi.org/10.1080/13506120410001667458.Full Text Link to Item
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Hou, Liming, Haiyan Shao, Yongbo Zhang, Hua Li, Nanda K. Menon, Elizabeth B. Neuhaus, John M. Brewer, et al. “Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation.” J Am Chem Soc 126, no. 7 (February 25, 2004): 1992–2005. https://doi.org/10.1021/ja036813f.Full Text Link to Item
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Colton, Carol A., Leila K. Needham, Candice Brown, Danielle Cook, Karima Rasheed, James R. Burke, Warren J. Strittmatter, Donald E. Schmechel, and Michael P. Vitek. “APOE genotype-specific differences in human and mouse macrophage nitric oxide production.” J Neuroimmunol 147, no. 1–2 (February 2004): 62–67. https://doi.org/10.1016/j.jneuroim.2003.10.015.Full Text Link to Item
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Dikalov, Sergey I., Michael P. Vitek, and Ronald P. Mason. “Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical.” Free Radic Biol Med 36, no. 3 (February 1, 2004): 340–47. https://doi.org/10.1016/j.freeradbiomed.2003.11.004.Full Text Link to Item
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Lynch, John R., Wen Tang, Haichen Wang, Michael P. Vitek, Ellen R. Bennett, Patrick M. Sullivan, David S. Warner, and Daniel T. Laskowitz. “APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.” J Biol Chem 278, no. 49 (December 5, 2003): 48529–33. https://doi.org/10.1074/jbc.M306923200.Full Text Link to Item
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Ohkubo, Nobutaka, Young-Don Lee, Atsuyuki Morishima, Toshio Terashima, Satoshi Kikkawa, Masaya Tohyama, Masahiro Sakanaka, et al. “Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade.” Faseb J 17, no. 2 (February 2003): 295–97. https://doi.org/10.1096/fj.02-0434fje.Full Text Link to Item
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Salloway, S., T. Gur, T. Berzin, R. Tavares, B. Zipser, S. Correia, V. Hovanesian, et al. “Erratum: Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease (Journal of the Neurological Sciences (2002) 203-204 (183-187) PII: S0022510X02002885.” Journal of the Neurological Sciences 206, no. 1 (January 15, 2003): 115. https://doi.org/10.1016/S0022-510X(02)00437-9.Full Text
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Salloway, S., T. Gur, T. Berzin, R. Tavares, B. Zipser, S. Correia, V. Hovanesian, et al. “Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease.” J Neurol Sci 203–204 (November 15, 2002): 183–87. https://doi.org/10.1016/s0022-510x(02)00288-5.Full Text Link to Item
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Thomas, Douglas D., Michael Graham Espey, Michael P. Vitek, Katrina M. Miranda, and David A. Wink. “Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction.” Proc Natl Acad Sci U S A 99, no. 20 (October 1, 2002): 12691–96. https://doi.org/10.1073/pnas.202312699.Full Text Link to Item
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Brown, C. M., C. A. Colton, P. M. Sullivan, and M. P. Vitek. “Sexual dimorphism in apolipoprotein E isoform specific regulation of nitric oxide release in targeted replacement mice.” Neurobiology of Aging 23, no. 1 (July 1, 2002): S404–S404.Link to Item
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Brown, Candice M., Elizabeth Wright, Carol A. Colton, Patrick M. Sullivan, Daniel T. Laskowitz, and Michael P. Vitek. “Apolipoprotein E isoform mediated regulation of nitric oxide release.” Free Radic Biol Med 32, no. 11 (June 1, 2002): 1071–75. https://doi.org/10.1016/s0891-5849(02)00803-1.Full Text Link to Item
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Colton, Carola A., Candice M. Brown, Meggan Czapiga, and Michael P. Vitek. “Apolipoprotein-E allele-specific regulation of nitric oxide production.” Ann N Y Acad Sci 962 (May 2002): 212–25. https://doi.org/10.1111/j.1749-6632.2002.tb04070.x.Full Text Link to Item
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Espey, Michael G., Katrina M. Miranda, Douglas D. Thomas, Sandhya Xavier, Deborah Citrin, Michael P. Vitek, and David A. Wink. “A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species.” Ann N Y Acad Sci 962 (May 2002): 195–206. https://doi.org/10.1111/j.1749-6632.2002.tb04068.x.Full Text Link to Item
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Rapoport, Mark, Hana N. Dawson, Lester I. Binder, Michael P. Vitek, and Adriana Ferreira. “Tau is essential to beta -amyloid-induced neurotoxicity.” Proc Natl Acad Sci U S A 99, no. 9 (April 30, 2002): 6364–69. https://doi.org/10.1073/pnas.092136199.Full Text Link to Item
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Colton, Carol A., Candice M. Brown, Danielle Cook, Leila K. Needham, Qing Xu, Meggan Czapiga, Ann M. Saunders, Donald E. Schmechel, Karima Rasheed, and Michael P. Vitek. “APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.” Neurobiol Aging 23, no. 5 (2002): 777–85. https://doi.org/10.1016/s0197-4580(02)00016-7.Full Text Link to Item
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Aoki, M., M. Tamatani, M. Taniguchi, A. Yamaguchi, Y. Bando, K. Kasai, Y. Miyoshi, et al. “Hypothermic treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain.” Brain Res Mol Brain Res 95, no. 1–2 (November 1, 2001): 117–28. https://doi.org/10.1016/s0169-328x(01)00255-8.Full Text Link to Item
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Castellani, R. J., P. L. Harris, L. M. Sayre, J. Fujii, N. Taniguchi, M. P. Vitek, H. Founds, C. S. Atwood, G. Perry, and M. A. Smith. “Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine.” Free Radic Biol Med 31, no. 2 (July 15, 2001): 175–80. https://doi.org/10.1016/s0891-5849(01)00570-6.Full Text Link to Item
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Matsuzaki, H., M. Tamatani, A. Yamaguchi, K. Namikawa, H. Kiyama, M. P. Vitek, N. Mitsuda, and M. Tohyama. “Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades.” Faseb J 15, no. 7 (May 2001): 1218–20.Link to Item
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Dawson, H. N., A. Ferreira, M. V. Eyster, N. Ghoshal, L. I. Binder, and M. P. Vitek. “Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.” Journal of Cell Science 114, no. 6 (April 23, 2001): 1179–87.
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Wink, D. A., K. M. Miranda, M. G. Espey, R. M. Pluta, S. J. Hewett, C. Colton, M. Vitek, M. Feelisch, and M. B. Grisham. “Mechanisms of the antioxidant effects of nitric oxide.” Antioxid Redox Signal 3, no. 2 (April 2001): 203–13. https://doi.org/10.1089/152308601300185179.Full Text Link to Item
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Mitsuda, N., N. Ohkubo, M. Tamatani, Y. D. Lee, M. Taniguchi, K. Namikawa, H. Kiyama, et al. “Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1.” J Biol Chem 276, no. 13 (March 30, 2001): 9688–98. https://doi.org/10.1074/jbc.M006153200.Full Text Link to Item
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Dawson, H. N., A. Ferreira, M. V. Eyster, N. Ghoshal, L. I. Binder, and M. P. Vitek. “Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice.” J Cell Sci 114, no. Pt 6 (March 2001): 1179–87. https://doi.org/10.1242/jcs.114.6.1179.Full Text Link to Item
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Yamaguchi, A., M. Tamatani, H. Matsuzaki, K. Namikawa, H. Kiyama, M. P. Vitek, N. Mitsuda, and M. Tohyama. “Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.” J Biol Chem 276, no. 7 (February 16, 2001): 5256–64. https://doi.org/10.1074/jbc.M008552200.Full Text Link to Item
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Colton, C. A., M. Czapiga, J. Snell-Callanan, O. N. Chernyshev, and M. P. Vitek. “Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport.” Biochim Biophys Acta 1535, no. 2 (February 14, 2001): 134–44. https://doi.org/10.1016/s0925-4439(00)00092-2.Full Text Link to Item
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Ohkubo, N., N. Mitsuda, M. Tamatani, A. Yamaguchi, Y. D. Lee, T. Ogihara, M. P. Vitek, and M. Tohyama. “Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway.” J Biol Chem 276, no. 5 (February 2, 2001): 3046–53. https://doi.org/10.1074/jbc.M005070200.Full Text Link to Item
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Singh, N., Y. Talalayeva, M. Tsiper, V. Romanov, A. Dranovsky, D. Colflesh, G. Rudamen, et al. “The role of Alzheimer's disease-related presenilin 1 in intercellular adhesion.” Exp Cell Res 263, no. 1 (February 1, 2001): 1–13. https://doi.org/10.1006/excr.2000.5098.Full Text Link to Item
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Tamatani, M., N. Mitsuda, H. Matsuzaki, H. Okado, S. Miyake, M. P. Vitek, A. Yamaguchi, and M. Tohyama. “A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2.” J Neurochem 75, no. 2 (August 2000): 683–93. https://doi.org/10.1046/j.1471-4159.2000.0750683.x.Full Text Link to Item
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Gamblin, T. C., M. E. King, H. Dawson, M. P. Vitek, J. Kuret, R. W. Berry, and L. I. Binder. “In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants.” Biochemistry 39, no. 20 (May 23, 2000): 6136–44. https://doi.org/10.1021/bi000201f.Full Text Link to Item
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Colton, C. A., O. N. Chernyshev, D. L. Gilbert, and M. P. Vitek. “Microglial contribution to oxidative stress in Alzheimer's disease.” Ann N Y Acad Sci 899 (2000): 292–307. https://doi.org/10.1111/j.1749-6632.2000.tb06195.x.Full Text Link to Item
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Espey, M. G., K. M. Miranda, M. Feelisch, J. Fukuto, M. B. Grisham, M. P. Vitek, and D. A. Wink. “Mechanisms of cell death governed by the balance between nitrosative and oxidative stress.” Ann N Y Acad Sci 899 (2000): 209–21. https://doi.org/10.1111/j.1749-6632.2000.tb06188.x.Full Text Link to Item
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Goldstein, L. B., M. P. Vitek, H. Dawson, and S. Bullman. “Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse.” Neuroscience 99, no. 4 (2000): 705–10. https://doi.org/10.1016/s0306-4522(00)00234-7.Full Text Link to Item
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Schwarzman, A. L., N. Singh, M. Tsiper, L. Gregori, A. Dranovsky, M. P. Vitek, C. G. Glabe, P. H. St George-Hyslop, and D. Goldgaber. “Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix.” Proc Natl Acad Sci U S A 96, no. 14 (July 6, 1999): 7932–37. https://doi.org/10.1073/pnas.96.14.7932.Full Text Link to Item
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Dikalov, S. I., M. P. Vitek, K. R. Maples, and R. P. Mason. “Amyloid beta peptides do not form peptide-derived free radicals spontaneously, but can enhance metal-catalyzed oxidation of hydroxylamines to nitroxides.” J Biol Chem 274, no. 14 (April 2, 1999): 9392–99. https://doi.org/10.1074/jbc.274.14.9392.Full Text Link to Item
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Vitek, M. P., J. Snell, H. Dawson, and C. A. Colton. “Modulation of nitric oxide production in human macrophages by apolipoprotein-E and amyloid-beta peptide.” Biochem Biophys Res Commun 240, no. 2 (November 17, 1997): 391–94. https://doi.org/10.1006/bbrc.1997.7408.Full Text Link to Item
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Mitsuda, N., A. D. Roses, and M. P. Vitek. “Transcriptional regulation of the mouse presenilin-1 gene.” J Biol Chem 272, no. 38 (September 19, 1997): 23489–97. https://doi.org/10.1074/jbc.272.38.23489.Full Text Link to Item
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Tabaton, M., G. Perry, M. Smith, M. Vitek, G. Angelini, D. Dapino, S. Garibaldi, D. Zaccheo, and P. Odetti. “Is amyloid beta-protein glycated in Alzheimer's disease?” Neuroreport 8, no. 4 (March 3, 1997): 907–9. https://doi.org/10.1097/00001756-199703030-00018.Full Text Link to Item
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Boteva, K., M. Vitek, H. Mitsuda, H. de Silva, P. T. Xu, G. Small, and J. R. Gilbert. “Mutation analysis of presenillin 1 gene in Alzheimer's disease.” Lancet 347, no. 8994 (January 13, 1996): 130–31. https://doi.org/10.1016/s0140-6736(96)90261-5.Full Text Link to Item
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Cochran, F. R., and M. P. Vitek. “Neuroinflammatory mechanisms in Alzheimer's disease: New opportunities for drug discovery.” Expert Opinion on Investigational Drugs 5, no. 4 (January 1, 1996): 449–55. https://doi.org/10.1517/13543784.5.4.449.Full Text
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Vitek, M. P. “Radical changes in beta-amyloid form and function.” Mol Chem Neuropathol 28, no. 1–3 (1996): 49–55. https://doi.org/10.1007/BF02815204.Full Text Link to Item
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Smith, M. A., L. M. Sayre, M. P. Vitek, V. M. Monnier, and G. Perry. “Early AGEing and Alzheimer's.” Nature 374, no. 6520 (March 23, 1995): 316. https://doi.org/10.1038/374316b0.Full Text Link to Item
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Schwarzman, A. L., L. Gregori, M. P. Vitek, S. Lyubski, W. J. Strittmatter, J. J. Enghilde, R. Bhasin, J. Silverman, K. H. Weisgraber, and P. K. Coyle. “Transthyretin sequesters amyloid beta protein and prevents amyloid formation.” Proc Natl Acad Sci U S A 91, no. 18 (August 30, 1994): 8368–72. https://doi.org/10.1073/pnas.91.18.8368.Full Text Link to Item
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Vitek, M. P., K. Bhattacharya, J. M. Glendening, E. Stopa, H. Vlassara, R. Bucala, K. Manogue, and A. Cerami. “Advanced glycation end products contribute to amyloidosis in Alzheimer disease.” Proc Natl Acad Sci U S A 91, no. 11 (May 24, 1994): 4766–70. https://doi.org/10.1073/pnas.91.11.4766.Full Text Link to Item
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Jacobsen, J. S., M. A. Spruyt, A. M. Brown, S. R. Sahasrabudhe, A. J. Blume, M. P. Vitek, H. A. Muenkel, and J. Sonnenberg-Reines. “The release of Alzheimer's disease beta amyloid peptide is reduced by phorbol treatment.” J Biol Chem 269, no. 11 (March 18, 1994): 8376–82.Link to Item
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Sahasrabudhe, S. R., A. M. Brown, J. D. Hulmes, J. S. Jacobsen, M. P. Vitek, A. J. Blume, and J. L. Sonnenberg. “Enzymatic generation of the amino terminus of the beta-amyloid peptide.” J Biol Chem 268, no. 22 (August 5, 1993): 16699–705.Link to Item
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Sahasrabudhe, S. R., M. A. Spruyt, H. A. Muenkel, A. J. Blume, M. P. Vitek, and J. S. Jacobsen. “Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells.” J Biol Chem 267, no. 35 (December 15, 1992): 25602–8.Link to Item
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Gubits, R. M., H. Yu, G. Casey, F. Munell, and M. P. Vitek. “Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells.” J Neurosci Res 33, no. 2 (October 1992): 297–305. https://doi.org/10.1002/jnr.490330213.Full Text Link to Item
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Rada, P., G. P. Mark, M. P. Vitek, R. M. Mangano, A. J. Blume, B. Beer, and B. G. Hoebel. “Interleukin-1 beta decreases acetylcholine measured by microdialysis in the hippocampus of freely moving rats.” Brain Res 550, no. 2 (June 7, 1991): 287–90. https://doi.org/10.1016/0006-8993(91)91330-4.Full Text Link to Item
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Jacobsen, J. S., A. J. Blume, and M. P. Vitek. “Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis.” Neurobiol Aging 12, no. 5 (1991): 585–92. https://doi.org/10.1016/0197-4580(91)90090-7.Full Text Link to Item
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Jacobsen, J. S., H. A. Muenkel, A. J. Blume, and M. P. Vitek. “A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs.” Neurobiol Aging 12, no. 5 (1991): 575–83. https://doi.org/10.1016/0197-4580(91)90089-3.Full Text Link to Item
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Donnelly, R. J., A. J. Friedhoff, B. Beer, A. J. Blume, and M. P. Vitek. “Interleukin-1 stimulates the beta-amyloid precursor protein promoter.” Cell Mol Neurobiol 10, no. 4 (December 1990): 485–95. https://doi.org/10.1007/BF00712843.Full Text Link to Item
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Garrett, K. M., N. Saito, R. S. Duman, M. S. Abel, R. A. Ashton, S. Fujimori, B. Beer, J. F. Tallman, M. P. Vitek, and A. J. Blume. “Differential expression of gamma-aminobutyric acidA receptor subunits.” Mol Pharmacol 37, no. 5 (May 1990): 652–57.Link to Item
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Heninger, C., N. Saito, J. F. Tallman, K. M. Garrett, M. P. Vitek, R. S. Duman, and D. W. Gallager. “Effects of continuous diazepam administration on GABAA subunit mRNA in rat brain.” J Mol Neurosci 2, no. 2 (1990): 101–7. https://doi.org/10.1007/BF02876917.Full Text Link to Item
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Goldgaber, D., H. W. Harris, T. Hla, T. Maciag, R. J. Donnelly, J. S. Jacobsen, M. P. Vitek, and D. C. Gajdusek. “Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.” Proc Natl Acad Sci U S A 86, no. 19 (October 1989): 7606–10. https://doi.org/10.1073/pnas.86.19.7606.Full Text Link to Item
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Blume, A. J., and M. P. Vitek. “Focusing on IL-1-promotion of beta-amyloid precursor protein synthesis as an early event in Alzheimer's disease.” Neurobiol Aging 10, no. 5 (1989): 406–8. https://doi.org/10.1016/0197-4580(89)90077-8.Full Text Link to Item
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Donnelly, R. J., J. S. Jacobsen, C. G. Rasool, A. J. Blume, and M. P. Vitek. “Isolation and expression of multiple forms of beta amyloid protein precursor cDNAs.” Prog Clin Biol Res 317 (1989): 925–37.Link to Item
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Vitek, M. P. “Increasing amyloid peptide precursor production and its impact on Alzheimer's disease.” Neurobiol Aging 10, no. 5 (1989): 471–73. https://doi.org/10.1016/0197-4580(89)90102-4.Full Text Link to Item
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Garrett, K. M., R. S. Duman, N. Saito, A. J. Blume, M. P. Vitek, and J. F. Tallman. “Isolation of a cDNA clone for the alpha subunit of the human GABA-A receptor.” Biochem Biophys Res Commun 156, no. 2 (October 31, 1988): 1039–45. https://doi.org/10.1016/s0006-291x(88)80949-5.Full Text Link to Item
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Vitek, M. P., C. G. Rasool, F. de Sauvage, S. M. Vitek, R. T. Bartus, B. Beer, R. A. Ashton, A. F. Macq, J. M. Maloteaux, and A. J. Blume. “Absence of mutation in the beta-amyloid cDNAs cloned from the brains of three patients with sporadic Alzheimer's disease.” Brain Res 464, no. 2 (September 1988): 121–31. https://doi.org/10.1016/0169-328x(88)90004-6.Full Text Link to Item
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Donnelly, R. J., C. G. Rasool, R. Bartus, S. Vitek, A. J. Blume, and M. Vitek. “Multiple forms of beta-amyloid peptide precursor RNAs in a single cell type.” Neurobiol Aging 9, no. 4 (1988): 333–38. https://doi.org/10.1016/s0197-4580(88)80078-2.Full Text Link to Item
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Gubler, U., A. O. Chua, A. S. Stern, C. P. Hellmann, M. P. Vitek, T. M. DeChiara, W. R. Benjamin, K. J. Collier, M. Dukovich, and P. C. Familletti. “Recombinant human interleukin 1 alpha: purification and biological characterization.” J Immunol 136, no. 7 (April 1, 1986): 2492–97.Link to Item
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Berger, E. M., M. P. Vitek, and C. M. Morganelli. “Transcript length heterogeneity at the small heat shock protein genes of Drosophila.” J Mol Biol 186, no. 1 (November 5, 1985): 137–48. https://doi.org/10.1016/0022-2836(85)90264-5.Full Text Link to Item
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Vitek, M. P., E. Devine, R. Dutkowski, A. Blume, D. Mullikin-Kilpatrick, D. L. Miller, W. T. Brown, and W. Wray. “Isolation of specific chromosomes and their DNA.” Gene Analysis Techniques 2, no. 1 (January 1, 1985): 16–21. https://doi.org/10.1016/0735-0651(85)90015-9.Full Text
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Vitek, M. P., and E. M. Berger. “Steroid and high-temperature induction of the small heat-shock protein genes in Drosophila.” J Mol Biol 178, no. 2 (September 15, 1984): 173–89. https://doi.org/10.1016/0022-2836(84)90138-4.Full Text Link to Item
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Vitek, M. P., C. M. Morganelli, and E. M. Berger. “Stimulation of cytoplasmic actin gene transcription and translation in cultured Drosophila cells by ecdysterone.” J Biol Chem 259, no. 3 (February 10, 1984): 1738–43.Link to Item
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Vitek, M. P., and E. Berger. “The regulation of low molecular weight heat-shock gene transcription by ecdysterone and high temperature.” Journal of Cell Biology 95, no. 2 II (January 1, 1982).
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Vitek, M. P., S. G. Kreissman, and R. H. Gross. “The isolation of ecdysterone inducible genes by hybridization subtraction chromatography.” Nucleic Acids Research 9, no. 5 (March 1981): 1191–1202. https://doi.org/10.1093/nar/9.5.1191.Full Text
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Conference Papers
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Enjoji, Shuhei, Ryotaro Yabe, Kazuhiro Yoshimura, Hideyoshi Kawasaki, Masashi Sakurai, Yusuke Sakai, Hiroko Takenouchi, et al. “The Role of PP2A inhibitor SET/I2PP2A in Gastric Cancer.” In Journal of Pharmacological Sciences, 133:S155–S155. JAPANESE PHARMACOLOGICAL SOC, 2017.Link to Item
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Pippa, R., A. Dominguez, D. J. Christensen, I. Moreno-Miralles, M. Blanco-Prieto, O. Bachs, K. Ye, M. P. Vitek, and M. D. Odero. “EFFECT OF FTY720 ON THE SET-PP2A COMPLEX IN ACUTE MYELOID LEUKEMIA. SET BINDING DRUGS HAVE ANTAGONISTIC ACTIVITY.” In Haematologica, 99:796–796. FERRATA STORTI FOUNDATION, 2014.Link to Item
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Agarwal, Anupriya, Ryan J. Meckenzie, Raffaella Pippa, Christopher A. Eide, Jessica Oddo, Jeffrey W. Tyner, Rosalie Sears, et al. “OP449, a Novel SET Antagonist, Is Cytotoxic To Leukemia Cells and Enhances Efficacy Of Tyrosine Kinase Inhibitors In Drug-Resistant Myeloid Leukemias.” In Blood, 122:2511–2511. American Society of Hematology, 2013. https://doi.org/10.1182/blood.v122.21.2511.2511.Full Text
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Li, Fengqiao, Dale J. Christensen, and Michael P. Vitek. “A REMYELINATING AGENT FOR TREATMENT OF MULTIPLE SCLEROSIS.” In Multiple Sclerosis Journal, 19:1417–1417. SAGE PUBLICATIONS LTD, 2013.Link to Item
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Janghorban, Mahnaz, Jessica Oddo, Tyler Risom, Amy Farrell, Michael P. Vitek, Rosalie C. Sears, and Dale J. Christensen. “Abstract 510: Activation of PP2A by SET antagonism destabilizes c-Myc and inhibits breast cancer growth.” In Cancer Research, 73:510–510. American Association for Cancer Research (AACR), 2013. https://doi.org/10.1158/1538-7445.am2013-510.Full Text
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Agarwal, Anupriya, Ryan MacKenzie, Jessica Oddo, Michael P. Vitek, Dale J. Christensen, and Brian J. Druker. “A Novel SET Antagonist (OP449) Is Cytotoxic to CML Cells, Including the Highly-Resistant BCR-ABLT315I Mutant, and Demonstrates Enhanced Efficacy in Combination with ABL Tyrosine Kinase Inhibitors,.” In Blood, 118:3757–3757. American Society of Hematology, 2011. https://doi.org/10.1182/blood.v118.21.3757.3757.Full Text
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Christensen, Dale J., Jessica Oddo, Karen Bond, Alicia Volkheimer, Youwei Chen, Evan Davis, Jon P. Gockerman, et al. “Targeting Destruction of Mcl-1 by Activation of Protein Phosphatase 2A In CLL and B-Cell Lymphomas.” In Blood, 116:1703–4. AMER SOC HEMATOLOGY, 2010.Link to Item
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Singh, Kshipra, Rupesh Chaturvedi, Daniel P. Barry, Mohammad Asim, Lori A. Coburn, Nuruddeen D. Lewis, M Blanca Piazuelo, Michael P. Vitek, and Keith T. Wilson. “Amelioration of Citrobacter rodentium Colitis by Apoe-Mimetic Peptide COG112 by Inhibition of NF-kappa B.” In Gastroenterology, 138:S410–S410. W B SAUNDERS CO-ELSEVIER INC, 2010.Link to Item
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Christensen, Dale J., Karen M. Bond, Alicia D. Volkheimer, Jessica Oddo, Youwei Chen, Jon P. Gockerman, Joseph O. Moore, et al. “The SET Oncogene, a Potent PP2A Inhibitor, Is Elevated in CLL and Antagonism of SET Induces Apoptosis.” In Blood, 114:802–802. American Society of Hematology, 2009. https://doi.org/10.1182/blood.v114.22.802.802.Full Text
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Schwarzman, A., S. Sarantseva, K. Soloviev, E. Talalaeva, and M. P. Vitek. “Presenilin 1 mediates cell-cell adhesion in transfected L-fibroblasts.” In New Trends in Alzheimer and Parkinson Related Disorders: Adpd 2009, edited by A. Fisher and I. Hanin, 187–90. MEDIMOND S R L, 2009.Link to Item
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Donahue, John Edward, J Douglas Coffin, Conrad E. Johanson, William E. Van Nostrand, Michael P. Vitek, Eddie Blay, Miles C. Miller, Paul Monfils, Paul N. McMillan, and Edward G. Stopa. “Effects of FGF-2 overexpression in the Dutch/Iowa APP Transgenic mouse.” In Journal of Neuropathology and Experimental Neurology, 67:511–511. LIPPINCOTT WILLIAMS & WILKINS, 2008.Link to Item
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Donahue, John Edward, Patricia A. Meitner, Rosemarie Tavares, Michael P. Vitek, and Cynthia L. Jackson. “Apolipoprotein E4 genotype influences RAGE and LRP-1 expression.” In Journal of Neuropathology and Experimental Neurology, 67:493–493. LIPPINCOTT WILLIAMS & WILKINS, 2008.Link to Item
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Cauble, Stephanie M., Mohammad Asim, Rupesh Chaturvedi, Daniel P. Barry, Nuruddeen D. Lewis, Kshipra Singh, Michael P. Vitek, and Keith T. Wilson. “The novel anti-inflammatory apoe-mimetic peptide COG112 inhibits helicobacter pylori-stimulated interleukin-8 expression in gastric epithelial cells.” In Gastroenterology, 134:A568–A568. W B SAUNDERS CO-ELSEVIER INC, 2008.Link to Item
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Donahue, John Edward, Patricia A. Meitner, Rosemarie Tavares, Michael P. Vitek, and Cynthia L. Jackson. “Apolipoprotein E4 Genotype Influences RAGE and LRP-1 Expression.” In Faseb Journal, Vol. 22. FEDERATION AMER SOC EXP BIOL, 2008.Link to Item
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Singh, Kshipra, Rupesh Chaturvedi, Daniel P. Barry, Mohammad Asim, Roxanne J. Wadia, Nuruddeen D. Lewis, Mary Kay Washington, Michael P. Vitek, and Keith T. Wilson. “ApoE-Mimetic peptide COG112 ameliorates dextran sulfate sodium colitis.” In Gastroenterology, 134:A264–A264. W B SAUNDERS CO-ELSEVIER INC, 2008.Link to Item
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Donahue, John Edward, J Douglas Coffin, Conrad E. Johanson, William E. Van Nostrand, Michael P. Vitek, Eddie Jr Blay, Miles C. Miller, Paul Monfils, Paul N. McMillan, and Edward G. Stopa. “Effects of FGF-2 Overexpression in the Dutch/Iowa APP Transgenic Mouse.” In Faseb Journal, Vol. 22, 2008.Link to Item
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Colton, C. A., and M. P. Vitek. “NOS2 in chronic neurodegeneration: Protection not damage.” In Journal of Neurochemistry, 102:12–12. BLACKWELL PUBLISHING, 2007.Link to Item
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Singh, Kshipra, Rupesh Chaturvedi, Mohammad Asim, Michael P. Vitek, and Keith T. Wilson. “Apoe-mimetic peptide inhibits host cell activation by Citrobacter rodentium.” In Gastroenterology, 132:A551–A551. W B SAUNDERS CO-ELSEVIER INC, 2007.Link to Item
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Donahue, John E., Brian D. Zipser, Conrad E. Johanson, Liliana Gonzalez, Rosemarie Tavares, Christine M. Hulette, Michael P. Vitek, Virginia Hovanesian, and Edward G. Stopa. “Cerebral amyloid angiopathy and microvascular protein leakage in Alzheimer's disease.” In Brain Pathology, 16:S80–S80. BLACKWELL PUBLISHING, 2006.Link to Item
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Mott, R. T., C. M. Hulette, M. P. Vitek, and C. A. Colton. “A beta 42 suppresses the anti-inflammatory alternative activation state in microglia: A potential role for Alzheimer's disease.” In Journal of Neuropathology and Experimental Neurology, 64:442–442. LIPPINCOTT WILLIAMS & WILKINS, 2005.Link to Item
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Butala, Parag, Stephen Salloway, Conrad E. Johanson, Liliana Gonzalez, Rose Tavares, Virginia Hovanesian, John E. Donahue, Christine M. Hullette, Michael P. Vitek, and Edward G. Stopa. “P3-183 Microvascular damage in Alzheimer's disease.” In Neurobiology of Aging, 25:S408–S408. Elsevier BV, 2004. https://doi.org/10.1016/s0197-4580(04)81335-6.Full Text
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Cantillana, Viviana, Michael P. Vitek, and Hana N. Dawson. “P2-106 Behavioral deficits in Tau knockout mice expressing mutant human APP.” In Neurobiology of Aging, 25:S254–S254. Elsevier BV, 2004. https://doi.org/10.1016/s0197-4580(04)80853-4.Full Text
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Brown, C. M., C. A. Colton, and M. P. Vitek. “Apolipoprotein E isoforms differentially regulate iNOS activity in male targeted replacement mice.” In Faseb Journal, 17:A1257–A1257. FEDERATION AMER SOC EXP BIOL, 2003.Link to Item
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Brown, C. M., C. A. Colton, and M. P. Vitek. “17 beta-estradiol modulates apolipoprotein E allele-specific regulation of microglial nitric oxide release.” In Faseb Journal, 17:A456–A456. FEDERATION AMER SOC EXP BIOL, 2003.Link to Item
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Brown, C. M., N. Mitsuda, H. N. Dawson, C. A. Colton, and M. P. Vitek. “A humanized NOS2 transgenic mouse.” In Faseb Journal, 17:A495–A495. FEDERATION AMER SOC EXP BIOL, 2003.Link to Item
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Brown, C. M., C. A. Colton, and M. P. Vitek. “Sex steroids differentially regulate apolipoprotein E4 isoform specific increases in nitric oxide production observed in targeted replacement mice.” In Neurobiology of Aging, 23:S404–S404. ELSEVIER SCIENCE INC, 2002.Link to Item
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Brown, C. M., M. P. Vitek, and N. Mitsuda. “Transgenic mouse model for human oxidative stress in aging.” In Neurobiology of Aging, 23:S239–S239. ELSEVIER SCIENCE INC, 2002.Link to Item
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Zipser, B. D., T. M. Berzin, T. Gur, V. Kuo-Leblanc, G. Hovanesian, C. E. Johanson, H. T. Chang, et al. “Blood-brain barrier integrity in Alzheimer's disease.” In Journal of Neuropathology and Experimental Neurology, 60:508–508. AMER ASSN NEUROPATHOLOGISTS INC, 2001.Link to Item
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Dikalov, S. I., M. P. Vitek, and R. P. Mason. “Cupric-amyloid b peptide complexes stimulate oxidation of ascorbate and generation of OH- radials.” In Free Radical Biology and Medicine, 31:S131–S131. PERGAMON-ELSEVIER SCIENCE LTD, 2001.Link to Item
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Czapiga, M., M. P. Vitek, and C. A. Colton. “ApoE isoform specific modulation of arginine transport.” In Faseb Journal, 14:A636–A636. FEDERATION AMER SOC EXP BIOL, 2000.Link to Item
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Stopa, E. G., W. Taylor, B. S. Rubin, A. D. Roses, D. Schmechel, V. KuoLeblanc, Y. Wei, et al. “Presenilin 1 (S182) and 2 (STM2) mRNA and protein in sporadic Alzheimer's disease (AD).” In Brain Pathology, 7:1204–1204. INT SOC NEUROPATHOLOGY, 1997.Link to Item
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VITEK, M. P., E. STOPA, F. J. SALLES, P. TONGE, H. VLASSARA, R. BUCALA, K. MANOGUE, and A. CERAMI. “Advanced glycosylation end-products contribute to amyloidosis in Alzheimer's disease.” In Research Advances in Alzheimer’S Disease and Related Disorders, edited by K. Iqbal, J. A. Mortimer, B. Winblad, and H. M. Wisniewski, 597–605. JOHN WILEY & SONS LTD, 1995.Link to Item
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SCHWARZMAN, A. L., L. GREGORI, M. P. VITEK, S. LYUBSKI, W. J. STRITTMATTER, J. J. ENGLHILD, R. BHASIN, et al. “TRANSTHYRETIN SEQUESTERS AMYLOID-BETA PROTEIN AND PREVENTS AMYLOID FORMATION.” In Neurobiology of Aging, 15:S53–54. ELSEVIER SCIENCE INC, 1994.Link to Item
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VITEK, M. P., K. BHATTACHARYA, J. M. GLENDENING, P. TONGE, Y. L. YI, E. STOPA, H. VLASSARA, R. BUCALA, K. MANOGUE, and A. CERAMI. “ADVANCED GLYCOSYLATION ENDPRODUCTS CONTRIBUTE TO AMYLOIDOSIS IN ALZHEIMERS-DISEASE.” In Neurobiology of Aging, 15:S79–80. ELSEVIER SCIENCE INC, 1994.Link to Item
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VITEK, M. P., D. MULLIKINKILPATRICK, and W. WRAY. “PURIFICATION OF HUMAN CHROMOSOME-21.” In Journal of Cell Biology, 99:A247–A247. ROCKEFELLER UNIV PRESS, 1984.Link to Item
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VITEK, M. P., and E. BERGER. “THE REGULATION OF LOW-MOLECULAR WEIGHT HEAT-SHOCK GENE-TRANSCRIPTION BY ECDYSTERONE AND HIGH-TEMPERATURE.” In Journal of Cell Biology, 95:A476–A476. ROCKEFELLER UNIV PRESS, 1982.Link to Item
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