Michaella Reif

Journal article Journal of pain and symptom management · December 2023 ContextThe phrase "goals of care" (GOC) is common in serious illness care, yet it lacks clarity and consistency. Understanding how GOC is used across healthcare contexts is an opportunity to identify and mitigate root causes of serious illness mis ... Full text Cite

Renin Kinetics Are Superior to Lactate Kinetics for Predicting In-Hospital Mortality in Hypotensive Critically Ill Patients.

Journal article Crit Care Med · January 1, 2022 OBJECTIVES: Whole blood lactate concentration is widely used in shock states to assess perfusion. We aimed to determine if the change in plasma renin concentration over time would be superior to the change in lactate concentration for predicting in-hospita ... Full text Link to item Cite

Nox4 mediates skeletal muscle metabolic responses to exercise.

Journal article Mol Metab · March 2021 OBJECTIVE: The immediate signals that couple exercise to metabolic adaptations are incompletely understood. Nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) produces reactive oxygen species (ROS) and plays a significant role in metabolic and va ... Full text Link to item Cite

Impact of Preoperative Platelet Count on Bleeding Risk and Allogeneic Transfusion in Multilevel Spine Surgery.

Journal article Spine · January 2021 Study designThis was an observational cohort study of patients receiving multilevel thoracic and lumbar spine surgery.ObjectiveThe aim of this study was to identify which patients are at high risk for allogeneic transfusion which may allo ... Full text Cite

Considerations beyond Stenosis for Carotid Endarterectomy in Treating Free-Floating Thrombus of the Carotid Artery.

Journal article Ann Vasc Surg · October 2019 BACKGROUND: Free-floating thrombus (FFT) of the carotid artery is an uncommon condition that can present with neurologic symptoms, often in the setting of ischemic stroke. The literature pertaining to the incidence and optimal treatment of this condition i ... Full text Link to item Cite

Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis.

Journal article Nat Commun · September 17, 2019 Diseases related to impaired blood flow such as peripheral artery disease (PAD) impact nearly 10 million people in the United States alone, yet patients with clinical manifestations of PAD (e.g., claudication and limb ischemia) have limited treatment optio ... Full text Link to item Cite

Iliofemoral deep venous thrombosis in kidney transplant patients can cause graft dysfunction.

Journal article J Vasc Surg Cases Innov Tech · March 2019 We present a series of kidney transplant dysfunction secondary to lower extremity deep venous thrombosis (DVT). A 70-year-old man underwent living unrelated kidney transplantation and presented 2 months postoperatively with acute kidney injury (AKI) second ... Full text Link to item Cite

Faces and Senses.

Journal article Obstetrics and gynecology · February 2019 Full text Cite

Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states.

Journal article Biochimica et biophysica acta · September 2016 Mixed lineage kinases, or MLKs, are members of the MAP kinase kinase kinase (MAP3K) family, which were originally identified among the activators of the major stress-dependent mitogen activated protein kinases (MAPKs), JNK and p38. During stress, the activ ... Full text Cite

Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling.

Journal article Nitric Oxide · May 1, 2016 Metabolic stress sensors like AMP-activated protein kinase (AMPK) are known to confer stress adaptation and promote longevity in lower organisms. This study demonstrates that activating the metabolic stress sensor AMP-activated protein kinase (AMPK) in end ... Full text Link to item Cite

Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions.

Journal article Free radical biology & medicine · December 2015 Vascular reactive oxygen species (ROS) are known to be involved in atherosclerosis development and progression. NADPH oxidase 4 (Nox4) is a constitutively active ROS-producing enzyme that is highly expressed in the vascular endothelium. Nox4 is unique in i ... Full text Cite