Scholars@Duke

• Research
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  Selected Grants

  • Racial and Geographic Disparities in Risk and Survival of Alzheimer's Disease and Related Dementias: Effects of Over/UnderDiagnosis and Disease Severity awarded by National Institutes of Health 2019 - 2024
  • Understanding Alzheimer's Disease in the Context of the Aging awarded by National Institutes of Health 2019 - 2024
  • Genetics of aging, health and longevity: focus on regulatory mechanisms and functional variants connecting aging and Alzheimer's disease" awarded by National Institutes of Health 2020 - 2024
  • Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field Center awarded by National Institutes of Health 2004 - 2019
  • Arabidopsis 2010: Regulatory Networks Controlling Root Growth and Differentiation awarded by  National Science Foundation 2010 - 2015
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Anderson, Danielle E., Kristin Pfeffermann, So Young Kim, Bevan Sawatsky, James Pearson, Mikhail Kovtun, David L. Corcoran, et al. “Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae.” Mbio 10, no. 3 (May 14, 2019). https://doi.org/10.1128/mBio.00826-19.
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    • Yashin, Anatoliy I., Fang Fang, Mikhail Kovtun, Deqing Wu, Matt Duan, Konstantin Arbeev, Igor Akushevich, et al. “Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.” Experimental Gerontology 107 (July 2018): 148–60. https://doi.org/10.1016/j.exger.2017.10.020.
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    • Fradin, Hélène, Karin Kiontke, Charles Zegar, Michelle Gutwein, Jessica Lucas, Mikhail Kovtun, David L. Corcoran, et al. “Genome Architecture and Evolution of a Unichromosomal Asexual Nematode.” Current Biology : Cb 27, no. 19 (October 2017): 2928-2939.e6. https://doi.org/10.1016/j.cub.2017.08.038.
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    • He, Liang, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G. Arbeev, Elena Loiko, Olivia Bagley, et al. “Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.” Frontiers in Genetics 8 (January 2017): 226. https://doi.org/10.3389/fgene.2017.00226.
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    • Kulminski, Alexander M., Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G. Arbeev, Elena Loiko, et al. “Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.” Plos Genetics 12, no. 11 (November 10, 2016): e1006314. https://doi.org/10.1371/journal.pgen.1006314.
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    • Yashin, Anatoliy I., Konstantin G. Arbeev, Liubov S. Arbeeva, Deqing Wu, Igor Akushevich, Mikhail Kovtun, Arseniy Yashkin, et al. “How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.” Biogerontology 17, no. 1 (February 2016): 89–107. https://doi.org/10.1007/s10522-015-9594-8.
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    • He, Liang, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G. Arbeev, Elena Loiko, Olivia Bagley, et al. “Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.” Frontiers in Genetics 7 (January 2016): 179. https://doi.org/10.3389/fgene.2016.00179.
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    • Yashin, Anatoliy I., Ilya Zhbannikov, Liubov Arbeeva, Konstantin G. Arbeev, Deqing Wu, Igor Akushevich, Arseniy Yashkin, et al. “Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures.” Frontiers in Genetics 7 (January 2016): 188. https://doi.org/10.3389/fgene.2016.00188.
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    • Yashin, Anatoliy I., Deqing Wu, Liubov S. Arbeeva, Konstantin G. Arbeev, Alexander M. Kulminski, Igor Akushevich, Mikhail Kovtun, et al. “Genetics of aging, health, and survival: dynamic regulation of human longevity related traits.” Frontiers in Genetics 6 (January 2015): 122. https://doi.org/10.3389/fgene.2015.00122.
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    • Kovtun, Mikhail, Igor Akushevich, and Anatoliy Yashin. “ON IDENTIFIABILITY OF MIXTURES OF INDEPENDENT DISTRIBUTION LAWS(, .).” Esaim. Probability and Statistics = Probabilites Et Statistique : P & S 18 (January 2014): 207–32. https://doi.org/10.1051/ps/2011166.
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    • Cui, Hongchang, Yueling Hao, Mikhail Kovtun, Viktor Stolc, Xing-Wang Deng, Hitoshi Sakakibara, and Mikiko Kojima. “Genome-wide direct target analysis reveals a role for SHORT-ROOT in root vascular patterning through cytokinin homeostasis.” Plant Physiology 157, no. 3 (November 2011): 1221–31. https://doi.org/10.1104/pp.111.183178.
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    • Akushevich, I., M. Kovtun, K. G. Manton, and A. I. Yashin. “Linear latent structure analysis and modelling of multiple categorical variables.” Computational and Mathematical Methods in Medicine 10, no. 3 (September 21, 2009): 203–18. https://doi.org/10.1080/17486700802259798.
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    • Kovtun, M., I. Akushevich, K. G. Manton, and H. D. Tolley. “Linear latent structure analysis: Mixture distribution models with linear constraints.” Statistical Methodology 4, no. 1 (January 1, 2007): 90–110. https://doi.org/10.1016/j.stamet.2006.04.001.
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    • Akushevich, I., K. G. Manton, A. Kulminski, M. Kovtun, J. Kravchenko, and A. Yashin. “Population models for the health effects of ionizing radiation.” Radiats Biol Radioecol 46, no. 6 (November 2006): 663–74.
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    • Manton, Kenneth G., Xiliang Gu, Hai Huang, and Mikhail Kovtun. “Fuzzy set analyses of genetic determinants of health and disability status.” Statistical Methods in Medical Research 13, no. 5 (October 2004): 395–408. https://doi.org/10.1191/0962280204sm374ra.
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  • Conference Papers

    • Arbeev, Konstantin G., Liubov S. Arbeeva, Ilya Y. Zhbannikov, Olivia Bagley, Igor Akushevich, Mikhail Kovtun, Alexander M. Kulminski, Irina V. Culminskaya, Svetlana V. Ukraintseva, and Anatoliy I. Yashin. “High-Resolution Analyses of Effects of Polygenic Risk Scores on Time-to-Event Outcomes in Longitudinal Studies.” In Genetic Epidemiology, 40:622–622. WILEY-BLACKWELL, 2016.
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    • “GENE-LEVEL META-ANALYSIS OF CANDIDATE GENES INVOLVED IN ALZHEIMER’S DISEASE AND LONGEVITY.” In The Gerontologist, 56:104–104. Oxford University Press (OUP), 2016. https://doi.org/10.1093/geront/gnw162.402.
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    • “ANALYSIS OF INTERACTIONS BETWEEN ALZHEIMER’S DISEASE CANDIDATE GENES AND THEIR IMPACT ON LONGEVITY.” In The Gerontologist, 56:103–103. Oxford University Press (OUP), 2016. https://doi.org/10.1093/geront/gnw162.400.
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    • Yashin, A. I., K. G. Arbeev, L. S. Arbeeva, D. Wu, I. Akushevich, A. Kulminski, M. Kovtun, I. Zhbannikov, and S. V. Ukraintseva. “Resistance to stresses and reliability of biological systems: Insights for genetic studies of human aging, health, and longevity.” In Proceedings  2nd International Symposium on Stochastic Models in Reliability Engineering, Life Science, and Operations Management, Smrlo 2016, 403–9, 2016. https://doi.org/10.1109/SMRLO.2016.70.
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    • Arbeev, Konstantin G., Liubov S. Arbeeva, Olivia Bagley, Hongzhe Duan, Igor Akushevich, Alexander M. Kulminski, Mikhail Kovtun, et al. “On Approaches to Improve Power in Analyses of Genetic Effects on Time-To-Event Outcomes in Longitudinal Studies.” In Genetic Epidemiology, 39:530–530. WILEY-BLACKWELL, 2015.
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    • Uemura, Rina, Igor Akushevich, Mikhail Kovtun, Arseniy P. Yashkin, Miaozhu Li, Konstantin G. Arbeev, Svetlana Ukraintseva, and Anatoliy I. Yashin. “Lipofuscin: as an aging marker in nematodes, Caenorhabditis elegans.” In Gerontologist, Vol. 55. OXFORD UNIV PRESS INC, 2015.
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    • “GENETIC HETEROGENEITY AND ITS ROLE IN GWAS OF HUMAN AGING AND LONGEVITY.” In The Gerontologist, 55:859–859. Oxford University Press (OUP), 2015. https://doi.org/10.1093/geront/gnv490.04.
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