Scholars@Duke

• Research
• 

  Selected Grants

  • Long Life Family Study: Duke Univ./Univ. of Southern Denmark Field Center awarded by National Institutes of Health 2004 - 2019
  • Genetics of Changes in Population Pyramids: Implications for Health Forecasting awarded by National Institutes of Health 2014 - 2018
  • Arabidopsis 2010: Regulatory Networks Controlling Root Growth and Differentiation awarded by  National Science Foundation 2010 - 2015
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • "GENE-LEVEL META-ANALYSIS OF CANDIDATE GENES INVOLVED IN ALZHEIMER’S DISEASE AND LONGEVITY." November 2016.  Full Text
    • "ANALYSIS OF INTERACTIONS BETWEEN ALZHEIMER’S DISEASE CANDIDATE GENES AND THEIR IMPACT ON LONGEVITY." November 2016.  Full Text
    • Arbeev, KG, Arbeeva, LS, Zhbannikov, IY, Bagley, O, Akushevich, I, Kovtun, M, Kulminski, AM, Culminskaya, IV, Ukraintseva, SV, and Yashin, AI. "High-Resolution Analyses of Effects of Polygenic Risk Scores on Time-to-Event Outcomes in Longitudinal Studies." November 2016.  Link to Item
    • Yashin, AI, Arbeev, KG, Arbeeva, LS, Wu, D, Akushevich, I, Kulminski, A, Kovtun, M, Zhbannikov, I, and Ukraintseva, SV. "Resistance to stresses and reliability of biological systems: Insights for genetic studies of human aging, health, and longevity." March 11, 2016.  Full Text  Open Access Copy
    • "GENETIC HETEROGENEITY AND ITS ROLE IN GWAS OF HUMAN AGING AND LONGEVITY." November 2015.  Full Text
    • Arbeev, KG, Arbeeva, LS, Bagley, O, Duan, H, Akushevich, I, Kulminski, AM, Kovtun, M, Culminskaya, IV, Wu, D, Ukraintseva, SV, and Yashin, AI. "On Approaches to Improve Power in Analyses of Genetic Effects on Time-To-Event Outcomes in Longitudinal Studies." November 2015.  Link to Item
    • Uemura, R, Akushevich, I, Kovtun, M, Yashkin, AP, Li, M, Arbeev, KG, Ukraintseva, S, and Yashin, AI. "Lipofuscin: as an aging marker in nematodes, Caenorhabditis elegans." November 2015.  Link to Item

  • Journal Articles

    • Yashin, AI, Fang, F, Kovtun, M, Wu, D, Duan, M, Arbeev, K, Akushevich, I, Kulminski, A, Culminskaya, I, Zhbannikov, I, Yashkin, A, Stallard, E, and Ukraintseva, S. "Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses." Experimental gerontology (October 26, 2017).  Full Text
    • Fradin, H, Kiontke, K, Zegar, C, Gutwein, M, Lucas, J, Kovtun, M, Corcoran, DL, Baugh, LR, Fitch, DHA, Piano, F, and Gunsalus, KC. "Genome Architecture and Evolution of a Unichromosomal Asexual Nematode." Current Biology : Cb 27, no. 19 (October 2017): 2928-2939.e6.  Full Text
    • He, L, Kernogitski, Y, Kulminskaya, I, Loika, Y, Arbeev, KG, Loiko, E, Bagley, O, Duan, M, Yashkin, A, Ukraintseva, SV, Kovtun, M, Yashin, AI, and Kulminski, AM. "Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases." Frontiers in Genetics 8 (January 2017): 226-null.  Full Text
    • Kulminski, AM, He, L, Culminskaya, I, Loika, Y, Kernogitski, Y, Arbeev, KG, Loiko, E, Arbeeva, L, Bagley, O, Duan, M, Yashkin, A, Fang, F, Kovtun, M, Ukraintseva, SV, Wu, D, and Yashin, AI. "Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality." Plos Genetics 12, no. 11 (November 10, 2016): e1006314-null.  Full Text
    • Yashin, AI, Arbeev, KG, Arbeeva, LS, Wu, D, Akushevich, I, Kovtun, M, Yashkin, A, Kulminski, A, Culminskaya, I, Stallard, E, Li, M, and Ukraintseva, SV. "How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity." Biogerontology 17, no. 1 (February 2016): 89-107. (Review)  Full Text  Open Access Copy
    • He, L, Kernogitski, Y, Kulminskaya, I, Loika, Y, Arbeev, KG, Loiko, E, Bagley, O, Duan, M, Yashkin, A, Ukraintseva, SV, Kovtun, M, Yashin, AI, and Kulminski, AM. "Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases." Frontiers in genetics 7 (January 2016): 179-.  Full Text  Open Access Copy
    • Yashin, AI, Zhbannikov, I, Arbeeva, L, Arbeev, KG, Wu, D, Akushevich, I, Yashkin, A, Kovtun, M, Kulminski, AM, Stallard, E, Kulminskaya, I, and Ukraintseva, S. "Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures." Frontiers in Genetics 7 (January 2016): 188-null.  Full Text  Open Access Copy
    • Yashin, AI, Wu, D, Arbeeva, LS, Arbeev, KG, Kulminski, AM, Akushevich, I, Kovtun, M, Culminskaya, I, Stallard, E, Li, M, and Ukraintseva, SV. "Genetics of aging, health, and survival: dynamic regulation of human longevity related traits." Frontiers in Genetics 6 (January 2015): 122-null.  Full Text  Open Access Copy
    • Kovtun, M, Akushevich, I, and Yashin, A. "ON IDENTIFIABILITY OF MIXTURES OF INDEPENDENT DISTRIBUTION LAWS(, .)." ESAIM. Probability and statistics = Probabilites et statistique : P & S 18 (January 2014): 207-232.  Full Text  Open Access Copy
    • Cui, H, Hao, Y, Kovtun, M, Stolc, V, Deng, X-W, Sakakibara, H, and Kojima, M. "Genome-wide direct target analysis reveals a role for SHORT-ROOT in root vascular patterning through cytokinin homeostasis." Plant Physiology 157, no. 3 (November 2011): 1221-1231.  Full Text  Open Access Copy
    • Akushevich, I, Kovtun, M, Manton, KG, and Yashin, AI. "Linear Latent Structure Analysis and Modelling of Multiple Categorical Variables." Computational and Mathematical Methods in Medicine 10, no. 3 (2009): 203-218.  Full Text
    • Kovtun, M, Akushevich, I, Manton, KG, and Tolley, HD. "Linear latent structure analysis: Mixture distribution models with linear constraints." Statistical Methodology 4, no. 1 (January 2007): 90-110.  Full Text
    • Akushevich, I, Manton, KG, Kulminski, A, Kovtun, M, Kravchenko, J, and Yashin, A. "Population models for the health effects of ionizing radiation." Radiatsionnaia biologiia, radioecologiia 46, no. 6 (November 2006): 663-674. (Review)
    • Manton, KG, Gu, X, Huang, H, and Kovtun, M. "Fuzzy set analyses of genetic determinants of health and disability status." Statistical methods in medical research 13, no. 5 (October 2004): 395-408.  Full Text

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