Elliott Mills
Professor Emeritus of Pharmacology & Cancer Biology

It is suspected that behavioral factors contribute to the genesis of hypertension in man. We employ a rat model in which offspring are subjected to maternal deprivation during the period between birth and weaning: an intervention which is associated with behavioral perturbations expressed in the mature rat. To test whether there are also perturbations in resting blood pressure and its reflex control we surgically implant a transducer/transmitter in the mature rat which allows measurement of blood pressure, heart rate and movement continuously in the unrestrained, unanesthetized animal. A ventilatory response to hypoxia may be implicated in sudden infant death syndrome (SIDS). We use physiological methods to measure the ventilation of the unrestrained unanesthetized rat from birth to weaning. The intent is to characterize the normal development and then to test whether environmental factors associated with SIDS also cause premature or retarded development of the hypoxic ventilatory response during the neonatal period.

Current Appointments & Affiliations

Contact Information

  • 6BOX 3813 Med Ctr, Durham, NC 27710
  • Bryan Res. Building, Durham, NC 27708

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