Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Duke University 2015
• 

  Previous Appointments & Affiliations

  • Medical Instructor in the Department of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2019 - 2021
• Recognition
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  Awards & Honors

  • Duke Pepper Center Research Career Development Award. Duke Pepper Older Americans Independence Center. 2020
  • Osteoarthritis Research Society International Scholarship. Osteoarthritis Research Society International (OARSI). 2013
  • The Hung Taiwan-Duke University Fellowship. Duke University.. Duke University. 2009
• Expertise
• 

  Subject Headings

  • Osteoarthritis
  • Osteoarthritis, Hip
  • Osteoarthritis, Knee
• Research
• 

  Selected Grants

  • Novel mechanisms of microRNA-mediated anabolic effects in age-related osteoarthritis awarded by National Institutes of Health 2023 - 2028
  • Development of an Early Osteoarthritis Diagnostic Panel via a Proteomic Approach awarded by Zimmer Biomet Company 2018 - 2022
  • Evaluation of Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial cells awarded by Bayer Corporation 2017 - 2019
  • Development of Methods to Quantify Biological and Pathological Aging of Cartilage awarded by National Institutes of Health 2011 - 2013
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Chen, Yu-Hsiu, Xin Zhang, Ching-Heng Chou, Ming-Feng Hsueh, David Attarian, Yi-Ju Li, and Virginia Byers Kraus. “Association of Dipeptidylpeptidase 4 (CD26) With Chondrocyte Senescence and Radiographic Progression in Knee Osteoarthritis.” Arthritis Rheumatol, January 27, 2023. https://doi.org/10.1002/art.42455.
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    • Chen, Yu-Hsiu, Xin Zhang, Kuei-Yueh Ko, Ming-Feng Hsueh, and Virginia Byers Kraus. “CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts.” Oxid Med Cell Longev 2022 (2022): 5503575. https://doi.org/10.1155/2022/5503575.
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    • Hsueh, Ming-Feng, Xin Zhang, Samuel S. Wellman, Michael P. Bolognesi, and Virginia B. Kraus. “Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression.” Arthritis Rheumatol 73, no. 1 (January 2021): 89–99. https://doi.org/10.1002/art.41486.
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    • Zhang, Xin, Ming-Feng Hsueh, Janet L. Huebner, and Virginia B. Kraus. “TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression.” Front Immunol 12 (2021): 758386. https://doi.org/10.3389/fimmu.2021.758386.
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    • Hsueh, M. -. F., M. P. Bolognesi, S. S. Wellman, and V. B. Kraus. “Anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial fluid immune cells.” Osteoarthritis Cartilage 28, no. 5 (May 2020): 639–45. https://doi.org/10.1016/j.joca.2020.01.013.
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    • Hsueh, M. -. F., S. Wellman, M. Bolognesi, and V. B. Kraus. “Folate receptor positive macrophages of osteoarthritic synovial fluid are high producers of IL-1β.” Osteoarthritis and Cartilage 28 (April 2020): S108–9. https://doi.org/10.1016/j.joca.2020.02.176.
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    • Zhang, X., M. -. F. Hsueh, and V. B. Kraus. “Evaluation of CD34+ hematopoietic stem cell-associated extracellular vesicles as a potential personalized therapy for osteoarthritis.” Osteoarthritis and Cartilage 28 (April 2020): S331–32. https://doi.org/10.1016/j.joca.2020.02.512.
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    • Hsueh, Ming-Feng, Patrik Önnerfjord, Michael P. Bolognesi, Mark E. Easley, and Virginia B. Kraus. “Analysis of "old" proteins unmasks dynamic gradient of cartilage turnover in human limbs.” Sci Adv 5, no. 10 (October 2019): eaax3203. https://doi.org/10.1126/sciadv.aax3203.
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    • Haraden, Collin A., Janet L. Huebner, Ming-Feng Hsueh, Yi-Ju Li, and Virginia Byers Kraus. “Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation.” Arthritis Res Ther 21, no. 1 (June 13, 2019): 146. https://doi.org/10.1186/s13075-019-1923-x.
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    • Hsueh, M. -. F., V. B. Kraus, and P. Önnerfjord. “Cartilage matrix remodelling differs by disease state and joint type.” Eur Cell Mater 34 (August 24, 2017): 70–82. https://doi.org/10.22203/eCM.v034a05.
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    • Taylor, Adam M., Ming-Feng Hsueh, Lakshminarayan R. Ranganath, James A. Gallagher, Jane P. Dillon, Janet L. Huebner, Jon B. Catterall, and Virginia B. Kraus. “Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing.” Rheumatology (Oxford) 56, no. 1 (January 2017): 156–64. https://doi.org/10.1093/rheumatology/kew355.
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    • Hsueh, Ming-Feng, Areej Khabut, Sven Kjellström, Patrik Önnerfjord, and Virginia Byers Kraus. “Elucidating the Molecular Composition of Cartilage by Proteomics.” J Proteome Res 15, no. 2 (February 5, 2016): 374–88. https://doi.org/10.1021/acs.jproteome.5b00946.
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    • Stabler, Thomas, Robert D. Zura, Ming-Feng Hsueh, and Virginia B. Kraus. “Xanthine oxidase injurious response in acute joint injury.” Clin Chim Acta 451, no. Pt B (December 7, 2015): 170–74. https://doi.org/10.1016/j.cca.2015.09.025.
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    • Catterall, Jonathan B., Ming F. Hsueh, Thomas V. Stabler, Christopher R. McCudden, Michael Bolognesi, Robert Zura, Joanne M. Jordan, Jordan B. Renner, Sheng Feng, and Virginia B. Kraus. “Protein modification by deamidation indicates variations in joint extracellular matrix turnover.” J Biol Chem 287, no. 7 (February 10, 2012): 4640–51. https://doi.org/10.1074/jbc.M111.249649.
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    • Catterall, J., M. -. F. Hsueh, T. V. Stabler, J. M. Renner, J. M. Jordan, and V. B. Kraus. “142 A UNIQUE DEAMIDATED CARTILAGE OLIGOMERIC MATRIX PROTEIN (COMP) BIOMARKER PREFERENTIALLY IDENTIFIES HIP OSTEOARTHRITIS.” Osteoarthritis and Cartilage 19 (September 2011): S72–S72. https://doi.org/10.1016/s1063-4584(11)60169-6.
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    • Taylor, A. M., M. -. F. Hsueh, L. R. Ranganath, J. A. Gallagher, J. B. Catterall, and V. B. Kraus. “159 ANALYSIS OF CARTILAGE BIOMARKERS OF TURNOVER AND AGING IN THE OSTEOARTHROPATHY OF ALKAPTONURIA.” Osteoarthritis and Cartilage 19 (September 2011): S80–S80. https://doi.org/10.1016/s1063-4584(11)60186-6.
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  • Book Sections

    • Hsueh, Ming-Feng, and Virginia Byers Kraus. “Biomarkers and osteoarthritis.” In Genomic and Precision Medicine Inflammatory and Metabolic Disease. Academic Press, 2019.

  • Book Reviews

    • Hsueh, Ming-Feng, Patrik Önnerfjord, and Virginia Byers Kraus. “Biomarkers and proteomic analysis of osteoarthritis.” Matrix Biol, October 2014. https://doi.org/10.1016/j.matbio.2014.08.012.
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  • Conference Papers

    • Hsueh, M. -. F., J. L. Huebner, C. A. Jacobs, C. Lattermann, K. P. Spindler, and V. B. Kraus. “ASSOCIATION OF MATRIX METALLOPEPTIDASE 9 WITH NEUTROPHIL ELASTASE IN JOINT INJURY AND OSTEOARTHRITIS PROGRESSION.” In Osteoarthritis and Cartilage, 29:S65–66, 2021.
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    • Hsueh, M. -. F., P. Onnerfjord, M. P. Bolognesi, M. E. Easley, and V. B. Kraus. “microRNAs and cartilage matrix protein turnover responded collectively to the stress of osteoarthritis.” In Osteoarthritis and Cartilage, 27:S59–S59. Elsevier BV, 2019. https://doi.org/10.1016/j.joca.2019.02.084.
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    • Hsueh, M. -. F., E. Montell, and V. B. Kraus. “AB0071 Effects of chondroitin sulphate and glucosamine on inflammatory cytokines in macrophages.” In Cytokines and Inflammatory Mediators. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. https://doi.org/10.1136/annrheumdis-2018-eular.2954.
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    • Hsueh, M. -. F., and V. B. Kraus. “AB0072 Evaluation of anti-inflammatory effects of naproxen sodium on human osteoarthritis synovial cells.” In Cytokines and Inflammatory Mediators. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. https://doi.org/10.1136/annrheumdis-2018-eular.3337.
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    • Hsueh, M. -. F., P. Onnerfjord, M. P. Bolognesi, M. E. Easley, and V. B. Kraus. “Differential cartilage turnover along the human lower limb revealed by protein deamidation.” In Osteoarthritis and Cartilage, 26:S32–S32. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.080.
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    • Hsueh, M. -. F., Y. Lu, S. S. Wellman, M. P. Bolognesi, and V. B. Kraus. “Functional folate receptor cell-associated inflammatory cytokines predict the progression of knee osteoarthritis.” In Osteoarthritis and Cartilage, 26:S121–22. Elsevier BV, 2018. https://doi.org/10.1016/j.joca.2018.02.266.
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    • Hsueh, M. -. F., V. B. Kraus, and P. Onnerfjord. “Quantitative assessment of cartilage remodeling in health and disease.” In Osteoarthritis and Cartilage, 25:S52–S52. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.097.
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    • Hsueh, M. -. F., Y. Lu, L. Wheeler, S. S. Wellman, M. P. Bolognesi, and V. B. Kraus. “Functional folate receptor cells within synovium and fluid as therapeutic targets for osteoarthritis.” In Osteoarthritis and Cartilage, 25:S42–43. Elsevier BV, 2017. https://doi.org/10.1016/j.joca.2017.02.082.
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    • Hsueh, M. -. F., A. Khabut, S. Kjellström, R. D. Zura, M. P. Bolognesi, P. Onnerfjord, and V. Kraus. “Mass spectrometry profiling of non-enzymatic deamidation of articular cartilage components suggests slower protein turnover in deep regions and in hips compared with knees.” In Osteoarthritis and Cartilage, 24:S17–S17. Elsevier BV, 2016. https://doi.org/10.1016/j.joca.2016.01.059.
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    • Hsueh, M. -. F., A. Khabut, S. Kjellström, P. Önnerfjord, and V. B. Kraus. “Cartilage permeability assessment based on proteomic analysis of plasma protein penetration.” In Osteoarthritis and Cartilage, 23:A132–33. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.863.
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    • Hsueh, M. -. F., V. B. Kraus, A. Khabut, and P. Önnerfjord. “Quantitative proteomics of articular cartilage using sequential extraction of transverse cryosections.” In Osteoarthritis and Cartilage, 23:A137–A137. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.871.
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    • Taylor, A. M., M. -. F. Hsueh, L. R. Ranganath, J. A. Gallagher, J. B. Catterall, and V. B. Kraus. “Analysis of cartilage biomarkers of aging and turnover in the osteoarthropathy of alkaptonuria.” In Osteoarthritis and Cartilage, 23:A135–A135. Elsevier BV, 2015. https://doi.org/10.1016/j.joca.2015.02.867.
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    • Hsueh, M. -. F., V. Kraus, A. Khabut, S. Kjellström, and P. Önnerfjord. “Discovery proteomics of articular cartilage using sequential extraction of transverse cryosections.” In Osteoarthritis and Cartilage, 22:S134–35. Elsevier BV, 2014. https://doi.org/10.1016/j.joca.2014.02.247.
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    • Hsueh, M. -. F., E. J. Soderblom, R. D. Zura, M. P. Bolognesi, and V. B. Kraus. “Study of deamidation of cartilage extracellular matrix proteins to investigate cartilage turnover.” In Osteoarthritis and Cartilage, 21:S112–S112. Elsevier BV, 2013. https://doi.org/10.1016/j.joca.2013.02.237.
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