Overview
Mohamad A. Mikati M.D., is the Wilburt C. Davison Professor of Pediatrics, Professor of Neurobiology, and Chief of the Division of Pediatric Neurology. Dr. Mikati’s clinical research has centered on characterization and therapy of pediatric epilepsy and neurology syndromes, describing several new pediatric neurological entities with two carrying his name (POSSUM syndromes # 3708 and 4468), developing novel therapeutic strategies for epilepsy and related disorders particularly Alternating Hemiplegia of Childhood, and applying cutting edge genetic and Magnetic Resonance Imaging techniques to drug resistant pediatric epilepsy. In the laboratory he has elucidated mechanisms of seizure related neuronal injury, particularly those related to the ceramide pathway, and demonstrated neuroprotective effects of several agents including erythropoietin. Most recently he has concentrated his laboratory research on the pathophysiology of ATP1A3 dysfunction in the brain as model for epilepsy and of Alternating Hemiplegia of Childhood. He has more than 290 peer reviewed publications, 400 abstracts 41 chapters one book and two booklets. He also has more than 10,497 citations in the literature with an h-index of 58 and an i-10index of 190. Dr. Mikati has written chapters on epilepsy and related disorders in the major textbooks of Pediatrics and Pediatric Neurology including Swaiman’s Pediatric Neurology and Nelson’s Pediatrics. Before joining Duke in 2008 he had completed his M.D. and Pediatric training at the American University of Beirut, his Neurology at the Massachusetts General Hospital, his Neurophysiology at Boston Children’s Hospital and had been on the Faculty at Harvard as Director of Research in the Epilepsy Program at Boston Children’s Hospital and then as Professor and Chairman, Department of Pediatrics, Founder and Director of the Adult and Pediatric Epilepsy Program at the American University of Beirut. Dr. Mikati has had several international leadership roles including being President of the Union of the Middle Eastern and Mediterranean Pediatric Societies, on the Standing Committee of the International Pediatric Association (IPA), Chair of the Strategic Advisory Group on Early Childhood Development of the IPA, Officer of the International Child Neurology Association, Consultant to UNICEF, WHO, and the American Board of Pediatrics. He was selected to organize and chair the American Epilepsy Society's Merritt-Putnam Symposium and was one of only two Pediatric Neurologists, initially chosen worldwide, on the WHO advisory committee for the International Classification of Disease. He has received several national and international honors including, among others, Merritt Putnam American Epilepsy Society Fellowship Award, Harvard Community Health Plan Peer recognition Award, Debs Research Award, Hamdan Award for contributions to Medicine, Hans Zellweger Award for contributions to Pediatric Neurology, Patient Choice Award and the Michael Frank Award for research and lifetime contributions to the field of Pediatric Neurology.
Current Appointments & Affiliations
Wilburt C. Davison Distinguished Professor
·
2009 - Present
Pediatrics, Neurology,
Pediatrics
Professor of Pediatrics
·
2008 - Present
Pediatrics, Neurology,
Pediatrics
Chief, Division of Pediatric Neurology
·
2008 - Present
Pediatrics, Neurology,
Pediatrics
Professor of Neurobiology
·
2008 - Present
Neurobiology,
Basic Science Departments
Faculty Network Member of the Duke Institute for Brain Sciences
·
2009 - Present
Duke Institute for Brain Sciences,
University Institutes and Centers
Affiliate of the Center for Brain Imaging and Analysis
·
2010 - Present
Duke-UNC Brain Imaging and Analysis Center,
Institutes and Centers
Associate of the Duke Initiative for Science & Society
·
2017 - Present
Duke Science & Society,
University Initiatives & Academic Support Units
Recent Publications
ATP1A3 Variants, Variably Penetrant Short QT Intervals, and Lethal Ventricular Arrhythmias.
Journal Article JAMA Pediatr · March 3, 2025 IMPORTANCE: Alternating hemiplegia of childhood (AHC) is a disorder that can result from pathogenic variants in ATP1A3-encoded sodium-potassium adenosine triphosphatase alpha 3 (ATP1A3). While AHC is primarily a neurologic disease, some individuals experie ... Full text Link to item CiteProgressive central cardiorespiratory rate downregulation and intensifying epilepsy lead to sudden unexpected death in epilepsy in mouse model of the most common human ATP1A3 mutation.
Journal Article Epilepsia · March 2025 OBJECTIVE: This study was undertaken to test the following hypotheses in the Atp1a3Mashl/+ mouse (which carries the most common human ATP1A3 (the major subunit of the neuronal Na+/K+-adenosine triphosphatase [ATPase]) mutation, D801N): sudden unexpected de ... Full text Link to item CiteCritical Events in Patients With Alternating Hemiplegia of Childhood: A Cohort Study Subgroup Analysis.
Journal Article AANA J · February 1, 2025 People with alternating hemiplegia of childhood undergoing general anesthesia are at risk for severe complications including critical bradycardia and hemiplegic incidents. We performed a 10-year historical cohort study and completed a subgroup analysis of ... Full text Link to item CiteRecent Grants
An integrated and diverse genomic medicine program for undiagnosed diseases
ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2028The role of the sodium potassium ATPase type alpha-3 subunit in sudden cardiac arrest
ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027Gene Therapy of ATP1A3 Related Disease
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2023 - 2025View All Grants
Education, Training & Certifications
American University of Beirut (Lebanon) ·
1980
M.D.