Scholars@Duke
Mohamad Abdul Mikati

Mohamad Abdul Mikati

Wilburt C. Davison Distinguished Professor
Pediatrics, Neurology
mohamad.mikati@duke.edu
Box 3936 Med Ctr, Durham, NC 27710
315 Trent Drive, Hanes House, Suite 345, Durham, NC 27710

Featured Works

De novo mutations in ATP1A3 cause alternating hemiplegia of childhood.

Journal article Nat Genet · September 2012 Featured Publication Alternating hemiplegia of childhood (AHC) is a rare, severe neurodevelopmental syndrome characterized by recurrent hemiplegic episodes and distinct neurological manifestations. AHC is usually a sporadic disorder and has unknown etiology. We used exome sequ ... Full text Link to item Cite

Epilepsy surgery in a developing country (Lebanon): ten years experience and predictors of outcome.

Journal article Epileptic Disord · September 2012 Featured Publication We present our 10-year experience and preoperative predictors of outcome in 93 adults and children who underwent epilepsy surgery at the American University of Beirut. Presurgical evaluation included video-EEG monitoring, MRI, neuropsychological assessment ... Full text Link to item Cite

Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy.

Journal article Am J Hum Genet · August 10, 2012 Featured Publication Idiopathic generalized epilepsy (IGE) is a complex disease with high heritability, but little is known about its genetic architecture. Rare copy-number variants have been found to explain nearly 3% of individuals with IGE; however, it remains unclear wheth ... Full text Link to item Cite

Electroencephalographic and seizure manifestations in two patients with folate receptor autoimmune antibody-mediated primary cerebral folate deficiency.

Journal article Epilepsy Behav · August 2012 Featured Publication Seizure semiology and electroencephalographic (EEG) manifestations of autoimmune-mediated cerebral folate deficiency (CFD) before and after therapy have yet to be fully characterized. Here, we report these findings in two such patients. Our first patient p ... Full text Link to item Cite

Possible induction of West syndrome by oxcarbazepine therapy in a patient with complex partial seizures.

Journal article Epileptic Disord · March 2012 Featured Publication Oxcarbazepine has been reported to precipitate myoclonic, generalised tonic-clonic, absence, and complex partial seizures, and carbamazepine to precipitate absences, myoclonic seizures and spasms. Here, we report a one-year, six-month-old girl with complex ... Full text Link to item Cite

Banding pattern on polarized hair microscopic examination and unilateral polymicrogyria in a patient with steroid sulfatase deficiency.

Journal article Arch Dermatol · January 2012 Featured Publication BACKGROUND: Several forms of ichthyosis are associated with neurologic manifestations, including Sjögren-Larsson syndrome, Refsum disease, and mental retardation-enteropathy-deafness-neuropathy-ichthyosis-keratoderma (MEDNIK) syndrome. We report a case of ... Full text Link to item Cite

Principles of drug treatment in children.

Journal article Handb Clin Neurol · 2012 Featured Publication Full text Link to item Cite

Two patients with an anti-N-methyl-D-aspartate receptor antibody syndrome-like presentation and negative results of testing for autoantibodies.

Journal article Pediatr Neurol · December 2011 Featured Publication We describe two boys whose distinct and remarkable clinical pictures suggested the possibility of anti-N-methyl-d-aspartate receptor antibody encephalitis. Both patients responded to immunotherapy, but neither manifested that antibody. Patient 1 exhibited ... Full text Link to item Cite

Inherited thrombophilia in childhood arterial stroke: data from Lebanon.

Journal article Pediatr Neurol · September 2011 Featured Publication Pediatric ischemic stroke still represents a burden, and more than half of the survivors will experience cognitive or motor disabilities. The objective of this study was to investigate the role of thrombophilia in a cohort of children with arterial ischemi ... Full text Link to item Cite

Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy.

Journal article Epilepsy Behav · May 2011 Featured Publication The superior longitudinal fasciculus (SLF) II and cingulum are two white matter tracts important for attention and other frontal lobe functions. These functions are often disturbed in children with drug-resistant (DR) partial epilepsy, even when no abnorma ... Full text Link to item Cite

Care for child development: basic science rationale and effects of interventions.

Journal article Pediatr Neurol · April 2011 Featured Publication The past few years have witnessed increasing interest in devising programs to enhance early childhood development. We review current understandings of brain development, recent advances in this field, and their implications for clinical interventions. An e ... Full text Link to item Cite

Potential neuroprotective effects of continuous topiramate therapy in the developing brain.

Journal article Epilepsy Behav · April 2011 Featured Publication Because antiepileptic drug therapy is usually given chronically with resulting concerns about long-term neurotoxicity, and because short-term topiramate (TPM) therapy has been reported to be neuroprotective against the effects of acute hypoxia, we investig ... Full text Link to item Cite

Electroencephalographic and seizure manifestations of pyridoxal 5'-phosphate-dependent epilepsy.

Journal article Epilepsy Behav · March 2011 Featured Publication We describe the electroencephalographic and clinical seizure manifestations of pyridoxal 5'-phosphate-dependent epilepsy (PLP-DE) in two patients [diagnosis confirmed by low cerebrospinal fluid (CSF) PLP, complete resolution of previously intractable seizu ... Full text Link to item Cite

Oculogyric crises secondary to lamotrigine overdosage.

Journal article Epilepsia · March 2011 Featured Publication We report four patients with no preexisting movement disorders who developed oculogyric crises secondary to lamotrigine toxicity and had resolution of these crises after dose reduction. Episode numbers ranged from 1-20 per day and episode duration from 2 s ... Full text Link to item Cite

Experience with hyperphenylalaninemia in a developing country: unusual clinical manifestations and a novel gene mutation.

Journal article J Child Neurol · February 2011 Featured Publication We report our experience in a cohort of patients with hyperphenylalaninemia in a tertiary care referral center in Lebanon. Forty-one sequential patients were studied: 34 classical phenylketonuria (PKU), 3 hyperphenylalaninemia (non-PKU), and 4 biopterin me ... Full text Link to item Cite

Differential expression of hippocampal connexins after acute hypoxia in the developing brain.

Journal article Brain Dev · November 2010 Featured Publication Acute hypoxia at postnatal day (P) 10 is an accepted model of human neonatal hypoxia which results, among other consequences, in increased hippocampal excitability. Hypoxic-ischemic injury, which mimics stroke, has been shown to result in changes in connex ... Full text Link to item Cite

The effect of vagus nerve stimulation therapy on body mass index in children.

Journal article Epilepsy Behav · September 2010 Featured Publication The effects of vagus nerve stimulation on weight in individuals with epilepsy are not fully characterized. A retrospective review was performed of all pediatric patients who underwent placement of a vagus nerve stimulator at Duke University Medical Center. ... Full text Link to item Cite

Quality of life after surgery for intractable partial epilepsy in children: a cohort study with controls.

Journal article Epilepsy Res · August 2010 Featured Publication PURPOSE: Investigate if quality of life (QOL) normalizes on long-term follow-up after surgery for partial epilepsy in children. METHODS: This is a cohort study with controls in which a consecutive cohort of nineteen 2-14-year-old children who underwent foc ... Full text Link to item Cite

Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study.

Journal article Brain · July 2010 Featured Publication Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully revealed common variants associated with disease r ... Full text Link to item Cite

Goldenhar syndrome associated with prenatal maternal Fluoxetine ingestion: Cause or coincidence?

Journal article Birth Defects Res A Clin Mol Teratol · July 2010 Featured Publication Goldenhar syndrome, also known as oculo-auriculo-vertebral spectrum, is a complex, heterogeneous condition characterized by abnormal prenatal development of facial structures. We present the occurrence of Goldenhar syndrome in an infant born to a woman wit ... Full text Link to item Cite

Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes.

Journal article Am J Hum Genet · May 14, 2010 Featured Publication Deletions at 16p13.11 are associated with schizophrenia, mental retardation, and most recently idiopathic generalized epilepsy. To evaluate the role of 16p13.11 deletions, as well as other structural variation, in epilepsy disorders, we used genome-wide sc ... Full text Link to item Cite

Therapy of infantile spasms: new opportunities and emerging challenges.

Journal article Epilepsy Behav · April 2010 Featured Publication Full text Link to item Cite

Intravenous immunoglobulin therapy in intractable childhood epilepsy: open-label study and review of the literature.

Journal article Epilepsy Behav · January 2010 Featured Publication Our aim was to investigate the long term effectiveness of intravenous immunoglobulin (IVIG) against intractable childhood epilepsy in the era of new antiepileptics and to determine the predictors of a favorable response in a prospective open-label add-on s ... Full text Link to item Cite

What is their fate after magnesium sulfate?

Journal article Neonatology · 2010 Featured Publication Full text Link to item Cite

Electroencephalographic changes in pyridoxine-dependant epilepsy: new observations.

Journal article Epileptic Disord · December 2009 Featured Publication OBJECTIVE: Pyridoxine-dependent epilepsy (PDE) is a rare disease, of which the EEG manifestations are only partially characterised. We report our observations of EEG recordings in four patients with PDE. MATERIALS AND METHODS: EEG tracings from four patien ... Full text Link to item Cite

Two new familial severe infantile spasm syndromes in males.

Journal article Epilepsy Behav · April 2009 Featured Publication We describe two new familial severe infantile spasm syndromes (ISSs) unrelated to Aristaless-related homeobox (ARX) gene mutation. Family A contains two male siblings each with dysmorphism, profound psychomotor delay, gastroesophageal reflux, infantile spa ... Full text Link to item Cite

Intraoperative electrocorticography and cortical stimulation in children.

Journal article J Clin Neurophysiol · April 2009 Featured Publication Intraoperative electrocorticography has been used in the surgical management of children with medically refractory epilepsy to localize anatomic areas of focal seizure onset, guide the extent, and completeness of resective epilepsy surgery, aid in function ... Full text Link to item Cite

Re: Epilepsy-associated bone mineral density loss should be prevented.

Journal article Neurology · March 10, 2009 Featured Publication Full text Link to item Cite

Quality of life after vagal nerve stimulator insertion.

Journal article Epileptic Disord · March 2009 Featured Publication AIM: Assess quality-of-life after vagal nerve stimulation and determine patient characteristics associated with improvement in quality-of-life. METHODS: Sixteen patients (11 children, 5 adults) who had vagal nerve stimulation at our center were studied. Qu ... Full text Link to item Cite

Approach to pediatric epilepsy surgery: State of the art, Part II: Approach to specific epilepsy syndromes and etiologies.

Journal article Eur J Paediatr Neurol · March 2009 Featured Publication The second of this 2-part review depicts the specific approach to the common causes of pediatric refractory epilepsy amenable to surgery. These include tumors, malformations due to abnormal cortical development, vascular abnormalities and certain epileptic ... Full text Link to item Cite

Approach to pediatric epilepsy surgery: State of the art, Part I: General principles and presurgical workup.

Journal article Eur J Paediatr Neurol · March 2009 Featured Publication In 1990, the National Institute of Health adopted epilepsy surgery in children as an option when medications fail. In the past few years several concepts have become increasingly recognized as key to a successful approach to epilepsy surgery in children. T ... Full text Link to item Cite

Intracarotid propofol testing: a comparative study with amobarbital.

Journal article Epilepsy Behav · March 2009 Featured Publication Twenty-five consecutive patients who underwent the Wada test using propofol as anesthetic were compared with 15 randomly selected patients who were tested using amobarbital. Time to verbal and nonverbal responses and time to motor power 3/5 did not differ ... Full text Link to item Cite

A child with refractory complex partial seizures, right temporal ganglioglioma, contralateral continuous electrical status epilepticus, and a secondary Landau-Kleffner autistic syndrome.

Journal article Epilepsy Behav · February 2009 Featured Publication A 7-year-old, right-handed girl started to have seizures at age 1 year 4 months. She developed normally until age 4 when she had worsening of seizures with auditory verbal agnosia, complete aphasia, and a behavioral disorder fulfilling the diagnostic crite ... Full text Link to item Cite

Deep brain stimulation as a mode of treatment of early onset pantothenate kinase-associated neurodegeneration.

Journal article Eur J Paediatr Neurol · January 2009 Featured Publication We report a case of a young girl with early onset pantothenate kinase-kssociated neurodegeneration (PKAN) whose initial clinical manifestation was ataxia at the age of 2.5 years. Subsequently the patient presented to us with refractory severe dystonia resu ... Full text Link to item Cite

Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus.

Journal article Epilepsy Res · October 2008 Featured Publication Status epilepticus (SE) induces a number of events leading to programmed cell death (PCD). The aim of our work is to study the time sequence of activation of different factors in experimental SE (intraperitoneal kainic acid (KA) model). We studied ceramide ... Full text Link to item Cite

Biotin-responsive basal ganglia disease: case report and review of the literature.

Journal article Neuropediatrics · October 2008 Featured Publication Biotin-responsive basal ganglia disease is a rare entity of which 10 cases have been reported in the literature. We report a case of biotin-responsive basal ganglia disease with similarities and differences compared to the previously reported cases by Ozan ... Full text Link to item Cite

Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms.

Journal article Brain Dev · September 2008 Featured Publication Ceramide is known to induce programmed cell death (PCD) in neural and non-neural tissues and to increase after kainic acid (KA) status epilepticus (SE). Ceramide increases have been shown to depend on NMDA receptor activation in the KA model, but these cha ... Full text Link to item Cite

Long-term tolerability and efficacy of lamotrigine in infants 1 to 24 months old.

Journal article J Child Neurol · August 2008 Featured Publication This open-label study was designed to evaluate the long-term tolerability and efficacy of lamotrigine in 1- to 24-month-old infants with partial seizures. The study enrolled both lamotrigine-naïve patients and patients who had been previously exposed to la ... Full text Link to item Cite

Predictors of bone density in ambulatory patients on antiepileptic drugs.

Journal article Bone · July 2008 Featured Publication BACKGROUND AND AIM: Antiepileptic drugs are associated with bone loss and fractures. Data in children is scarce and the impact of new therapies and of low vitamin D is not clear. This study assessed predictors of bone mineral density (BMD) in 225 ambulator ... Full text Link to item Cite

Motor variant of chronic inflammatory demyelinating polyneuropathy in a child.

Journal article Pediatr Neurol · June 2008 Featured Publication Only 2 cases of pure motor chronic demyelinating inflammatory polyneuropathy in the pediatric age group have been reported in the literature. We report on a motor variant of chronic demyelinating inflammatory polyneuropathy with anti-ganglioside antibodies ... Full text Link to item Cite

Adjunctive lamotrigine for partial seizures in patients aged 1 to 24 months.

Journal article Neurology · May 27, 2008 Featured Publication OBJECTIVE: This randomized, double-blind, placebo-controlled trial was conducted to assess the efficacy and tolerability of adjunctive lamotrigine for the treatment of partial seizures in infants aged 1 to 24 months. METHODS: The study used a responder-enr ... Full text Link to item Cite

Iron deficiency in young Lebanese children: association with elevated blood lead levels.

Journal article J Pediatr Hematol Oncol · May 2008 Featured Publication OBJECTIVE: To measure the prevalence of transferrin saturation (TS) <12%, and iron-deficiency anemia (IDA) in Lebanese children, and their association with dietary habits, sociodemographic characteristics, and blood lead levels. PROCEDURE: A cross-sectiona ... Full text Link to item Cite

Cerebral sinus thrombosis in a patient with humoral immunodeficiency on intravenous immunoglobulin therapy: a case report.

Journal article Neuropediatrics · April 2008 Featured Publication We present the case of an 11-year-old boy with humoral immunodeficiency on monthly intravenous immunoglobulins (IVIG) infusions, evaluated for recurrent, brief, neurological deficits secondary to cerebral sinus thrombosis without any identifiable hypercoag ... Full text Link to item Cite

Response of infantile spasms to levetiracetam.

Journal article Neurology · February 12, 2008 Featured Publication Full text Link to item Cite

Gap junctional intercellular communication in hypoxia-ischemia-induced neuronal injury.

Journal article Prog Neurobiol · January 2008 Featured Publication Brain hypoxia-ischemia is a relatively common and serious problem in neonates and in adults. Its consequences include long-term histological and behavioral changes and reduction in seizure threshold. Gap junction intercellular communication is pivotal in t ... Full text Link to item Cite

Marked benefits in physical activity and well-being, but not in functioning domains, 2 years after successful epilepsy surgery in children.

Journal article Epilepsy Behav · January 2008 Featured Publication In this first study comparing epilepsy-specific quality-of-life measures of children after epilepsy surgery (2.4 years after focal resection) with those of a matched comparison group of nonoperated patients, seizure severity, medication side effects, overa ... Full text Link to item Cite

Expanding spectrum of paroxysmal events in children: potential mimickers of epilepsy.

Journal article Pediatr Neurol · November 2007 Featured Publication Paroxysmal events in children can mimic epileptic seizures, and many of them have only been recently described, or are only now being increasingly recognized. An awareness of the different mimickers of epilepsy and the art of history-taking will help pedia ... Full text Link to item Cite

High-performance liquid chromatography method for quantifying sphingomyelin in rat brain.

Journal article J Chromatogr B Analyt Technol Biomed Life Sci · November 1, 2007 Featured Publication A rapid, reproducible and accurate high-performance liquid chromatographic (HPLC) method for the quantitative determination of sphingomyelin in rat brain was developed and validated using normal-phase silica gel column, acetonitrile-methanol-water (65:18:1 ... Full text Link to item Cite

Functional recovery following resection of an epileptogenic focus in the motor hand area.

Journal article Epilepsy Behav · November 2007 Featured Publication Despite recent technical advances, the surgical management of epileptic foci in the primary motor area, especially the motor hand area, continues to represent a significant challenge because of the risk of permanent neurological deficit. We describe the ca ... Full text Link to item Cite

Risk factors for development of subclinical hypothyroidism during valproic acid therapy.

Journal article J Pediatr · August 2007 Featured Publication OBJECTIVE: To identify risk factors for subclinical hypothyroidism (SCH) (thyroid-stimulating hormone levels >5 mIU/mL) in patients receiving valproate (VPA) therapy. STUDY DESIGN: During a period of 2 years, consecutive patients with epilepsy receiving VP ... Full text Link to item Cite

Importance of voltage-dependent inactivation in N-type calcium channel regulation by G-proteins.

Journal article Pflugers Arch · April 2007 Featured Publication Direct regulation of N-type calcium channels by G-proteins is essential to control neuronal excitability and neurotransmitter release. Binding of the G(betagamma) dimer directly onto the channel is characterized by a marked current inhibition ("ON" effect) ... Full text Link to item Cite

Genetic diagnosis in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls.

Journal article Neurology · March 27, 2007 Featured Publication Lafora disease (LD) can be diagnosed by skin biopsy, but this approach has both false negatives and false positives. Biopsies of other organs can also be diagnostic but are more invasive. Genetic diagnosis is also possible but can be inconclusive, for exam ... Full text Link to item Cite

Venous sinus thrombosis in a renal transplant patient.

Journal article Transplantation · March 27, 2007 Featured Publication Full text Link to item Cite

A patient with duplication (7)(p22.1pter) characterized by array-CGH.

Journal article Am J Med Genet A · January 15, 2007 Featured Publication Approximately 40 patients with terminal duplication of the distal short arm of chromosome 7 have been reported, the smallest being dup(7)(p21). We report here on a patient with a smaller duplication, dup(7)(p22.1), detected on G-banding and characterized b ... Full text Link to item Cite

Effects of a single dose of erythropoietin on subsequent seizure susceptibility in rats exposed to acute hypoxia at P10.

Journal article Epilepsia · January 2007 Featured Publication PURPOSE: To determine if posthypoxia treatment with erythropoietin (EPO) has protective effects against subsequent susceptibility to seizure related neuronal injury in rat pups subjected to acute hypoxia at P10. METHODS: Four groups of rats were manipulate ... Full text Link to item Cite

Brain malformation and infantile spasms in a SCAD deficiency patient.

Journal article Pediatr Neurol · January 2007 Featured Publication This report presents a case of short-chain acyl-coenzyme A (CoA) dehydrogenase deficiency with a previously unreported presentation with brain malformations and infantile spasms. This female infant developed repeated tonic clonic seizures at the age of 3(1 ... Full text Link to item Cite

Two randomized vitamin D trials in ambulatory patients on anticonvulsants: impact on bone.

Journal article Neurology · December 12, 2006 Featured Publication OBJECTIVE: To investigate the effects of two doses of vitamin D given over 1 year on bone density in ambulatory patients on long-term antiepileptic drug (AED) therapy. METHODS: We conducted two parallel, randomized, controlled trials in 72 adults (18 to 54 ... Full text Link to item Cite

Benign pediatric localization-related epilepsies.

Journal article Epileptic Disord · December 2006 Featured Publication By definition, benign epilepsy syndromes occur in patients with no significant prenatal, perinatal, or postnatal complications, normal psychomotor development and negative laboratory and neuroimaging work-up, respond well to therapy, and remit without sequ ... Link to item Cite

Novel mutation causing partial biotinidase deficiency in a Syrian boy with infantile spasms and retardation.

Journal article J Child Neurol · November 2006 Featured Publication We report a case of partial biotinidase deficiency (plasma biotinidase levels: 1.30 nm/minute/mL) in a 7-month-old boy who presented with evidence of perinatal distress followed by developmental delay, hypotonia, seizures, and infantile spasms without alop ... Full text Link to item Cite

Benign pediatric localization-related epilepsies. Part I. Syndromes in infancy.

Journal article Epileptic Disord · September 2006 Featured Publication There is currently increasing interest in identifying and classifying pediatric benign epilepsy syndromes and recently several new syndromes have been recognized. Benign epilepsy syndromes, by definition, occur in children with normal developmental history ... Link to item Cite

Exacerbation of vocal tics after temporal lobectomy.

Journal article Epilepsy Behav · August 2006 Featured Publication We describe a woman with intractable temporal lobe epilepsy secondary to dysgenesis of the left temporal lobe who had a marked and long-term exacerbation of her preexisting vocal tics after a temporal lobectomy that completely controlled her seizures. The ... Full text Link to item Cite

Normalization of quality of life three years after temporal lobectomy: a controlled study.

Journal article Epilepsia · May 2006 Featured Publication PURPOSE: The goal of epilepsy surgery is not merely to control previously intractable seizures, but also to improve quality of life (QOL). Our goals were to assess, in our Middle Eastern population, the QOL of adults with temporal lobe epilepsy (TLE) 3 yea ... Full text Link to item Cite

Alternating ibuprofen and acetaminophen in the treatment of febrile children: a pilot study [ISRCTN30487061].

Journal article BMC Med · March 4, 2006 Featured Publication BACKGROUND: Alternating ibuprofen and acetaminophen for the treatment of febrile children is a prevalent practice among physicians and parents, despite the lack of evidence on effectiveness or safety. This randomized, double-blind and placebo-controlled cl ... Full text Link to item Cite

Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor.

Journal article Biochim Biophys Acta · March 2006 Featured Publication Maurocalcine (MCa) is a 33-amino acid residue peptide toxin initially isolated from the scorpion Scorpio maurus maurus. Its structural and functional features make it resembling many Cell Penetrating Peptides. In particular, MCa exhibits a characteristic p ... Full text Link to item Cite

Effects of magnesium sulfate in kainic acid-induced status epilepticus.

Journal article J Med Liban · 2006 Featured Publication Because magnesium has antiseizure effects in some animal models of epilepsy, and possible neuroprotective effects in some models of neuronal injury, we aimed to investigate its effects in the kainic acid (KA) model of status epilepticus (SE) in prepubescen ... Link to item Cite

Pilocarpine seizures cause age-dependent impairment in auditory location discrimination.

Journal article J Exp Anal Behav · November 2005 Featured Publication Children who have status epilepticus have continuous or rapidly repeating seizures that may be life-threatening and may cause life-long changes in brain and behavior. The extent to which status epilepticus causes deficits in auditory discrimination is unkn ... Full text Link to item Cite

Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial [ISRCTN11886401].

Journal article BMC Pediatr · September 6, 2005 Featured Publication BACKGROUND: The antipyretic effectiveness of rectal versus oral acetaminophen is not well established. This study is designed to compare the antipyretic effectiveness of two rectal acetaminophen doses (15 mg/kg) and (35 mg/kg), to the standard oral dose of ... Full text Link to item Cite

Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain.

Journal article Brain Res Dev Brain Res · June 9, 2005 Featured Publication Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O2) had as adults increased aggression (handling test), memory impairment (water maze test), and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O2 from P0 to P21) had incr ... Full text Link to item Cite

Facial nerve palsy with acute otitis media during the first 2 weeks of life.

Journal article J Child Neurol · May 2005 Featured Publication A full-term male newborn presented to us at the age of 2 weeks with left facial weakness that had started at the age of 4 days and steadily progressed over a 10-day period. Physical examination revealed a complete unilateral left peripheral facial nerve pa ... Full text Link to item Cite

Pattern-induced partial seizures with repetitive affectionate kissing: an unusual manifestation of right temporal lobe epilepsy.

Journal article Epilepsy Behav · May 2005 Featured Publication We report a case of recurrent partial seizures that were often precipitated by looking up a flight of stairs and included spitting as well as repetitive affectionate kissing automatisms. These seizures were shown by long-term video/EEG monitoring to be of ... Full text Link to item Cite

Management of Landau-Kleffner syndrome.

Journal article Paediatr Drugs · 2005 Featured Publication Landau-Kleffner syndrome (LKS) is an acquired epileptic aphasia disorder in which children, usually 3-8 years of age who have developed age-appropriate speech, experience language regression with verbal auditory agnosia, abnormal epileptiform activity, beh ... Full text Link to item Cite

Refractory calculation-induced idiopathic generalized epilepsy: a case report and review of the literature.

Journal article Epilepsia · 2005 Featured Publication We report a case with calculation-induced idiopathic generalized epilepsy (IGE) that, unlike most patients with IGE, was refractory to medications. This patient had a family history of (1) a similar condition in a relative of hers who, however, did not hav ... Full text Link to item Cite

Febrile seizures. From molecular biology to clinical practice.

Journal article Neurosciences (Riyadh) · January 2005 Featured Publication Febrile seizures occur between the age of 3 months and 5 years with a temperature of 38 degrees C or higher, and are either simple or complex. Eight gene loci have been identified to be associated with certain cases of autosomal dominant familial febrile s ... Link to item Cite

Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats.

Journal article Brain Inj · December 2004 Featured Publication PURPOSE: To investigate if energy precursor supplementation is neuroprotective in two neuroexcitotoxicity models; the kainate and the kainate followed by chronic phenobarbital models. METHODS: Rats in experiment 1 received 1% creatine or cyclocreatine chow ... Full text Link to item Cite

Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats.

Journal article Epilepsy Behav · April 2004 Featured Publication OBJECTIVE: The goal of this study was to investigate the potential protective effects of nimodipine (ND), a calcium channel blocker, on the acute manifestations and long-term behavioral sequalae of experimental status epilepticus (SE). METHODS: Three group ... Full text Link to item Cite

Effects of epilepsy surgery on quality of life: a controlled study in a Middle Eastern population.

Journal article Epilepsy Behav · February 2004 Featured Publication The purpose of this study was to investigate which areas of quality of life (QOL) change after epilepsy surgery and generate QOL data specific to the Lebanese population. The QOL of 20 consecutive patients 1 year after surgery was compared (using the ESI-5 ... Full text Link to item Cite

Localized morphea: a rare adverse effect of valproic acid.

Journal article Pediatr Neurol · September 2003 Featured Publication Morphea, a specific type of cutaneous sclerosis, is known in the pediatric age group, but not as an adverse effect to the antiepileptic valproic acid. We report a 14-year-old male patient with absence seizures who, after treatment with valproic acid, devel ... Full text Link to item Cite

Blood lead concentrations in 1-3 year old Lebanese children: a cross-sectional study.

Journal article Environ Health · April 15, 2003 Featured Publication BACKGROUND: Childhood lead poisoning has not made the list of national public health priorities in Lebanon. This study aims at identifying the prevalence and risk factors for elevated blood lead concentrations (B-Pb >or= 100 microg/L) among 1-3 year old ch ... Full text Link to item Cite

Hippocampal programmed cell death after status epilepticus: evidence for NMDA-receptor and ceramide-mediated mechanisms.

Journal article Epilepsia · March 2003 Featured Publication PURPOSE: Status epilepticus (SE) can result in acute neuronal injury with subsequent long-term age-dependent behavioral and histologic sequelae. To investigate potential mechanisms that may underlie SE-related neuronal injury, we studied the occurrence of ... Full text Link to item Cite

Stages of status epilepticus in the developing brain.

Journal article Epilepsy Res · 2003 Featured Publication BACKGROUND: Adult rats undergo five distinct electrographic stages during status epilepticus (SE). Whether developing animals manifest those stages is not yet known. GOALS: Determine in the kainic acid (KA) model: (1) the EEG stages of SE in P15 and P35 ra ... Full text Link to item Cite

Symptomatic antiepileptic drug associated vitamin D deficiency in noninstitutionalized patients: an under-diagnosed disorder.

Journal article J Med Liban · 2003 Featured Publication Four noninstitutionalized patients, 4 months - 51 years old, presented out of 421 patients with epilepsy seen within a period of 2 years with serious symptoms of vitamin D deficiency secondary to chronic antiepileptic drug therapy. Presenting symptoms incl ... Link to item Cite

Lack of apoptosis in the hypoxic brain of a rat model mimicking cyanotic heart disease.

Journal article Brain Inj · October 2002 Featured Publication OBJECTIVE: To assess the effect of chronic hypoxia on brain neuronal apoptosis, an animal model mimicking cyanotic heart disease was utilized. METHODS: Rats were placed in an hypoxic environment at birth and oxygen levels were maintained at 10% in an air-t ... Full text Link to item Cite

Isolated digital gangrene complicating hepatitis a infection in a child.

Journal article J Clin Rheumatol · August 2002 Featured Publication Hepatitis A virus is rarely associated with extrahepatic complications. A child presented with a history suggesting Raynaud's phenomenon and severe digital gangrene, as a complication of hepatitis A infection. Coagulation study results (protein C, protein ... Full text Link to item Cite

Efficacy, tolerability, and kinetics of lamotrigine in infants.

Journal article J Pediatr · July 2002 Featured Publication OBJECTIVES: To investigate the efficacy, tolerability, and kinetics of lamotrigine during the first year of life. STUDY DESIGN: We studied 13 infants with intractable seizures; 7 had partial seizures and 7 had infantile spasms (1 had both). Patients receiv ... Full text Link to item Cite

Effect of antiepileptic drugs on bone density in ambulatory patients.

Journal article Neurology · May 14, 2002 Featured Publication BACKGROUND: Long-term antiepileptic drug (AED) use causes multiple abnormalities in calcium and bone metabolism that have been most extensively described in institutionalized patients. The objective is to determine the effect of AED on vitamin D levels and ... Full text Link to item Cite

Efficacy of intravenous immunoglobulin in Landau-Kleffner syndrome.

Journal article Pediatr Neurol · April 2002 Featured Publication We administered 2 gm/kg of intravenous gamma globulin (IVIG) to each of five consecutive patients with Landau-Kleffner syndrome, over 4 days. We compared the 1-month baseline to that following IVIG using a severity score assessing speech, comprehension, be ... Full text Link to item Cite

Medical treatment of patients with infantile spasms.

Journal article Clin Neuropharmacol · 2002 Featured Publication Infantile spasms are the main feature in West syndrome, an age-related epilepsy syndrome that affects 1 in every 2,000-4,000 infants. The authors provide a comprehensive review of the literature about infantile spasms and their therapy. In the United State ... Full text Link to item Cite

Cerebral mycotic aneurysm in a child with Down's syndrome: a unique association.

Journal article J Child Neurol · November 2001 Featured Publication Mycotic aneurysms are rare complications in patients with infective endocarditis, particularly in the pediatric population. We report a case of mycotic aneurysm of the middle cerebral artery complicating bacterial endocarditis in a child with Down's syndro ... Full text Link to item Cite

Time sequence and types of memory deficits after experimental status epilepticus.

Journal article Epilepsy Res · February 2001 Featured Publication P35 rats subjected to kainate induced status epilepticus (SE) subsequently underwent four consecutive series of the Morris Water Maze. They demonstrated, compared with controls, an early (P46-49), and subsequent (P60-63) disturbance in acquisition, but not ... Full text Link to item Cite

Anticonvulsant action and long-term effects of gabapentin in the immature brain.

Journal article Neuropharmacology · 2001 Featured Publication The anticonvulsant action and the long-term effects on learning, memory and behavior of the new generation antiepileptic drug gabapentin (GBP) were investigated in immature animals. Kainic acid (KA) was administered to rats on postnatal day (P) 35. Animals ... Full text Link to item Cite

Isolated adipic aciduria.

Journal article Pediatr Neurol · January 2001 Featured Publication Adipic acid can appear, in combination with other dicarboxylic acids, in the urine of patients in a number of underlying metabolic diseases. A child with seizures and mental retardation of unknown etiology who was found to have elevated isolated adipic aci ... Full text Link to item Cite

Classification of epilepsy syndromes and role of genetic factors.

Journal article Pediatr Neurol · January 2001 Featured Publication In this report the types of epilepsy syndromes seen in children in a tertiary referral center in Beirut, Lebanon were studied and the importance of consanguinity and family history in the occurrence of these syndromes was investigated. Records of 230 pedia ... Full text Link to item Cite

Alternating hemiplegia of childhood: clinical manifestations and long-term outcome.

Journal article Pediatr Neurol · August 2000 Featured Publication We present our analysis of 44 patients with alternating hemiplegia of childhood. The clinical course usually consisted of three phases. The first was dominated by abnormal eye movements and dystonic episodes, the second by hemiplegic spells and psychomotor ... Full text Link to item Cite

Successful use of intravenous immunoglobulin as initial monotherapy in Landau-Kleffner syndrome.

Journal article Epilepsia · July 2000 Featured Publication PURPOSE: There is a need for new and more effective therapies for Landau-Kleffner syndrome. In this article we present the first case in which a patient with Landau-Kleffner syndrome was given intravenous immunoglobulin (IVIG) as his first and only therapy ... Full text Link to item Cite

Fatality from hepatitis A in a child taking valproate.

Journal article J Child Neurol · February 2000 Featured Publication We report an 8-year-old boy with complex partial seizures due to congenital stroke, treated with valproate for more than 3 years (the last 2 years were on monotherapy) with no complications during that period except for transient thrombocytopenia. His sist ... Full text Link to item Cite

Rheumatic fever in children: a 15-year experience in a developing country.

Journal article Pediatr Cardiol · 2000 Featured Publication Clinical data from 91 patients with rheumatic fever (RF), who were hospitalized at a tertiary hospital in Lebanon between 1980 and 1995, were reviewed retrospectively. Age on hospitalization was 11.1+/-2.9 years (mean +/- SD, range 3-17 years). Nineteen pa ... Full text Link to item Cite

Potential hepatotoxicity of lamotrigine.

Journal article Pediatr Neurol · January 2000 Featured Publication Lamotrigine is a new antiepileptic drug that is effective for a broad range of seizures in adults and children. Three children with seizures of different causes who were treated with lamotrigine and developed reversible hepatotoxicity are reported. In one ... Full text Link to item Cite

Unusual presentation of Kearns-Sayre syndrome in early childhood.

Journal article Pediatr Neurol · November 1999 Featured Publication Congenital glaucoma and insulin-dependent diabetes mellitus were the predominant presenting signs in a patient with Kearns-Sayre syndrome. Thereafter, he developed short stature, pigmentary retinopathy, progressive external ophthalmoplegia, and ataxia. The ... Full text Link to item Cite

Alternating hemiplegia of childhood.

Journal article Pediatr Neurol · October 1999 Featured Publication Full text Link to item Cite

Consequences of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain.

Journal article Brain Res Dev Brain Res · March 12, 1999 Featured Publication To investigate if AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor activation contributes to acute manifestations and long term consequences of status epilepticus (SE), we administered the AMPA receptor antagonist NBQX to P35 rats u ... Full text Link to item Cite

Adrenoleukodystrophy associated with vitiligo and ulcerative colitis.

Journal article Eur Neurol · 1999 Featured Publication Adrenoleukodystrophy (ALD) is an X-linked inherited disorder of lipid metabolism usually presenting in childhood or early adolescence. It is a progressive disease with symptoms of adrenal insufficiency and central nervous system demyelination. The patholog ... Full text Link to item Cite

Transient hypertrophic cardiomyopathy in the newborn following multiple doses of antenatal corticosteroids.

Journal article Am J Perinatol · 1999 Featured Publication Postnatal exposure to steroids has been associated with hypertrophic cardiomyopathy (HCM) in the newborn. Such an effect has not been described in infants born to mothers who received antenatal steroids. We report three newborns whose mothers were treated ... Full text Link to item Cite

Gabapentin in the treatment of refractory partial epilepsy in children with intellectual disability.

Journal article J Intellect Disabil Res · December 1998 Featured Publication Twenty-six children with intellectual disability and six normal children, all suffering from refractory partial seizures, received open-label gabapentin (range = 10-50 mg kg(-1) day(-1); mean = 26.7 mg kg(-1) day(-1) as an add-on medication to their antiep ... Link to item Cite

IVIG in Landau-Kleffner syndrome.

Journal article Pediatr Neurol · November 1998 Featured Publication Link to item Cite

Electroencephalographic discharges of temporal lobe seizures in children and young adults.

Journal article Electroencephalogr Clin Neurophysiol · November 1998 Featured Publication We investigated the discharge morphology and propagation patterns of electroencephalographic seizures of temporal lobe onset in 21 children and young adults who underwent invasive long-term EEG monitoring (LTM). Of those, 15 subsequently underwent anterior ... Full text Link to item Cite

Comparison of valproate and phenobarbital treatment after status epilepticus in rats.

Journal article Neurology · July 1998 Featured Publication OBJECTIVE: To investigate the long-term effects of two widely used antiepileptic medications, valproate and phenobarbital, on learning and behavior in the kainic acid (KA) model of epilepsy. BACKGROUND: Prior clinical and animal studies have demonstrated t ... Full text Link to item Cite

Early onset neonatal spontaneous pneumopericardium.

Journal article J Med Liban · 1998 Featured Publication Neonatal pneumopericardium is a rare clinical condition which usually occurs in association with other air leaks, especially when there is severe lung pathology, post vigorous resuscitation, or in presence of assisted ventilation. We report the first case ... Link to item Cite

Lamotrigine in absence and primary generalized epilepsies.

Journal article J Child Neurol · November 1997 Featured Publication Although lamotrigine has been approved in the United States as adjunctive therapy for partial seizures in patients older than 12 years, there is increasing evidence that it is just as effective, if not more effective, in the treatment of generalized seizur ... Full text Link to item Cite

Landau-Kleffner syndrome: consistent response to repeated intravenous gamma-globulin doses: a case report.

Journal article Epilepsia · April 1997 Featured Publication PURPOSE: Although several treatments have been tried for Landau-Kleffner syndrome (LKS) too many patients are refractory to known therapies. We report an 8-year-old girl who failed other therapies but who had a consistent response after treatment with intr ... Full text Link to item Cite

Focal features in West syndrome indicating candidacy for surgery.

Journal article Pediatr Neurol · April 1997 Featured Publication A subgroup of patients with West syndrome (WS) also have focal features, and some of these patients respond to surgical intervention. To determine the incidence of focal features in patients with WS and to establish the correlation of these features with o ... Full text Link to item Cite

Acute effects of MK801 on kainic acid-induced seizures in neonatal rats.

Journal article Epilepsy Res · January 1997 Featured Publication Kainic acid (KA) causes behavioral and electrographic status epilepticus (SE) in rats of all ages. In adult rats, the noncompetitive N-methyl-D-aspartate (NMDA) channel blocker MK801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]-cyclohepten-5,10-imine ) is a ... Full text Link to item Cite

Focal brain dysfunction in a 41-year old man with familial alternating hemiplegia.

Journal article Eur Arch Psychiatry Clin Neurosci · 1997 Featured Publication The acute pathophysiologic changes during hemiplegic spells and the long-term outcome of alternating hemiplegia remain obscure. In a 41-year-old male with familial alternating hemiplegia we found an increase in right frontal cerebral blood flow 3 h into a ... Full text Link to item Cite

Hypsarrhythmia: frequency of variant patterns and correlation with etiology and outcome.

Journal article Neurology · January 1997 Featured Publication To determine the frequency and significance of the EEG features of hypsarrhythmia, we analyzed the pre-ACTH records of 53 consecutive patients with infantile spasms for the severity of the following abnormalities: disorganization of background, slowing, hi ... Full text Link to item Cite

Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain.

Journal article Brain Res Dev Brain Res · September 2, 1996 Featured Publication Because of the critical role of excitatory amino acids (EAAs) in epileptogenesis and seizure-induced brain damage, EAA antagonists are now being considered as a possible therapy for seizures. However, during development EAAs play a pivotal role in learning ... Full text Link to item Cite

Pharyngeal dysesthesia as an aura in temporal lobe epilepsy.

Journal article Epilepsia · September 1996 Featured Publication PURPOSE: Because oral, buccal, and sometimes oral-pharyngeal manifestations in epilepsy are linked to the central-temporal region, we studied 3 patients with childhood-onset partial seizures that consistently began with pharyngeal dysesthesias, described a ... Full text Link to item Cite

Efficacy of gabapentin therapy in children with refractory partial seizures.

Journal article J Pediatr · June 1996 Featured Publication Thirty-two children with refractory partial epilepsy received open-label gabapentin as an additional medication to their antiepileptic drug regimen. Gabapentin was given in a dose ranging from 10 to 50 mg/kg per day (mean dose, 26.7 mg/kg daily). All patie ... Full text Link to item Cite

Differential diagnosis of staring spells in children: a video-EEG study.

Journal article Pediatr Neurol · April 1996 Featured Publication Staring is frequently a nonepileptic manifestation in children. To differentiate epileptic versus nonepileptic staring, we reviewed clinical and video-EEG findings in 143 patients, aged 5 months to 43 years, monitored for staring episodes. In 79 patients s ... Full text Link to item Cite

Behavioral side effects of gabapentin in children.

Journal article Epilepsia · January 1996 Featured Publication We report 7 children who received gabapentin (GBP) as adjunctive medic ation and subsequently developed behavioral side effects. These behavioral changes consisted of intensification of baseline behaviors as well as new behavioral problems. Behaviors that ... Full text Link to item Cite

Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals.

Journal article Brain Res Dev Brain Res · October 27, 1995 Featured Publication We investigated the role of excitatory amino acids in the activation of the phosphoinositide pathway during kainic acid-induced seizures in mature and immature animals. Kainic acid caused more severe seizures in the immature animals, but no hippocampal dam ... Full text Link to item Cite

The preoperative evaluation of the child with epilepsy.

Journal article Neurosurg Clin N Am · July 1995 Featured Publication This article reviews the preoperative evaluation of the child with intractable epilepsy. The importance of the history and the clinical manifestations of the seizures, and the results of electrophysiology, neurophysiology, and neuroimaging studies are disc ... Link to item Cite

Pseudoseizure manifestations in two preschool age children.

Journal article Seizure · June 1995 Featured Publication We report two patients with epilepsy with pseudoseizures at age 6 years. Both presented with intractable staring spells. Pseudoseizures were provoked and aborted by suggestion, leading to the diagnosis. In both patients, evidence of a neuropsychological di ... Full text Link to item Cite

EEG prior to hemispherectomy: correlation with outcome and pathology.

Journal article Electroencephalogr Clin Neurophysiol · April 1995 Featured Publication Hemispherectomy, for the treatment of seizures, is highly successful but has a significant morbidity rate. The procedure is usually restricted to patients with an intractable seizure disorder and hemiparesis. Because of the inherent risk of surgery, patien ... Full text Link to item Cite

HPLC measurement, blood distribution, and pharmacokinetics of oral clotrimazole, potentially useful antisickling agent.

Journal article Clin Chem · March 1995 Featured Publication Clotrimazole (CLT) has recently been shown to be a potent and specific inhibitor of the Ca(2+)-activated K+ channel and to thereby prevent K+ loss and cellular dehydration of sickled erythrocytes. This evidence suggests that oral CLT may be a useful new th ... Link to item Cite

Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children.

Journal article Brain Dev · 1995 Featured Publication Sixteen children who had focal cortical resections for medically intractable epilepsy were preoperatively evaluated with 99mtechnetium-labelled hexamethylpropyleneamineoxime single photon emission computed tomography (99mTc-HMPAO SPECT). Video-EEG monitori ... Full text Link to item Cite

Mesial temporal sclerosis: pathogenesis and significance.

Journal article Pediatr Neurol · January 1995 Featured Publication Mesial temporal sclerosis (MTS) is a common pathologic finding in patients with temporal lobe epilepsy. Rarely MTS can be detected in children during the first decade of life, but is not commonly found until adolescence. Although the etiology of MTS remain ... Full text Link to item Cite

Psychogenic seizures: video telemetry observations in 27 patients.

Journal article Pediatr Neurol · January 1995 Featured Publication Psychogenic seizures are unusual during the first decade of life. To compare the clinical features of psychogenic seizures in young children with those of teenagers, the long-term electroencephalographic and video monitoring studies of all patients younger ... Full text Link to item Cite

Use of subdural grids and strip electrodes to identify a seizure focus in children.

Journal article Pediatr Neurosurg · 1995 Featured Publication For patients with intractable seizures, the best surgical outcome is achieved following precise localization of the seizure focus. Scalp EEG monitoring may be insufficient and chronic subdural invasive EEG monitoring has therefore been advocated. At Childr ... Full text Link to item Cite

Long-term behavioral deficits following pilocarpine seizures in immature rats.

Journal article Epilepsy Res · December 1994 Featured Publication The effect of seizures on subsequent long-term behavior was studied in immature rats. A similar severity of seizures were induced in 20-day old rats (P20) and 45-day old rats (P45) by intraperitoneal injections of pilocarpine at doses of 200 mg/kg and 380 ... Full text Link to item Cite

Technetium-99m HmPAO brain SPECT and outcome of hemispherectomy for intractable seizures.

Journal article Pediatr Neurol · October 1994 Featured Publication With recent descriptions of the modified hemispherectomies and hemicorticectomy, there has been renewed interest in hemispherectomy for treatment of intractable seizures with hemiparesis. Because long-term outcome remains uncertain, patient selection remai ... Full text Link to item Cite

Flunarizine for treatment of partial seizures: results of a concentration-controlled trial.

Journal article Neurology · October 1994 Featured Publication The National Institutes of Health sponsored a randomized, double-blind, multicenter, placebo-controlled trial of flunarizine (FNR) in epileptic patients receiving concomitant phenytoin (PHT) or carbamazepine (CBZ). Because of FNR's long half-life (up to 7 ... Full text Link to item Cite

Efficacy of felbamate in therapy for partial epilepsy in children.

Journal article J Pediatr · September 1994 Featured Publication Thirty children (2 to 17 years of age) with refractory partial seizures received open-label felbamate as an add-on medication to their background antiepileptic drugs. The dose was increased up to a maximum of 45 mg/kg. Compared with baseline seizure activi ... Full text Link to item Cite

Phenobarbital modifies seizure-related brain injury in the developing brain.

Journal article Ann Neurol · September 1994 Featured Publication To investigate the potential role of drug therapy in preventing or exacerbating seizure-related brain injury in the prepubescent brain, we administered kainic acid to rats at postnatal day 35. Therapy with daily phenobarbital was started directly before or ... Full text Link to item Cite

Measurement of felbamate by wide-bore capillary gas chromatography and flame ionization detection.

Journal article Clin Chem · May 1994 Featured Publication Felbamate, a newly developed antiepileptic agent, has been demonstrated to control partial and generalized seizures effectively. We have developed a gas-chromatographic method for the determination of felbamate, using a wide-bore capillary column, a flame ... Link to item Cite

Quisqualic acid-induced seizures during development: a behavioral and EEG study.

Journal article Epilepsia · 1994 Featured Publication Quisqualic acid (QA) is an excitatory amino acid analogue that binds to the glutamate ionotropic receptor subclass AMPA (alpha-amino-3 hydroxy-5 methyl-4 isoxazol propionic acid) and metabotropic receptor phospholipase C. To study its epileptogenic propert ... Full text Link to item Cite

Relationship of carbamazepine reduction rate to seizure frequency during inpatient telemetry.

Journal article Epilepsia · 1994 Featured Publication To establish guidelines for medication reduction during inpatient telemetry, the records of 18 children and young adults with refractory partial seizures undergoing carbamazepine (CBZ) reductions during continuous video/EEG telemetry were reviewed. Six pat ... Full text Link to item Cite

Effect of temperature on kainic acid-induced seizures.

Journal article Brain Res · December 17, 1993 Featured Publication The effects of body temperature on kainic acid-induced seizures and seizure-related brain damage were examined in rats. In rats with status epilepticus induced by intraperitoneal injection of 12 mg/kg of kainic acid (KA), ictal discharges were decreased by ... Full text Link to item Cite

Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure-associated hippocampal damage.

Journal article Brain Res · October 29, 1993 Featured Publication Basic fibroblast growth factor (bFGF) has been shown to have neuroprotective effects in animal models of ischemia. To determine whether bFGF is protective against seizure-induced brain damage, we administered bFGF through osmotic pumps prior to, and after ... Full text Link to item Cite

Effects of quisqualic acid and glutamate on subsequent learning, emotionality, and seizure susceptibility in the immature and mature animal.

Journal article Brain Res · October 1, 1993 Featured Publication To compare the long-term behavioral effects of chronic administration of excitatory amino acids in the mature and immature brain quisqualic acid (QA) and glutamate (GLU) were administered intraventricularly by osmotic pumps over 7 days in 20- and 60-day-ol ... Full text Link to item Cite

Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility.

Journal article Brain Res Dev Brain Res · May 21, 1993 Featured Publication To determine the long-term effects of seizures on the developing brain we kindled 20-, 40-, and 60-day-old rats to stage 5 seizures and then elicited an additional 15 seizures using the same kindling stimulation. At age 80 days, all animals that reached st ... Full text Link to item Cite

Facilitation of infantile spasms by partial seizures.

Journal article Epilepsia · 1993 Featured Publication We report 16 patients with infantile spasms in whom onset of the clusters of spasms appeared to be triggered by close temporal association with partial seizures. Common features included the presence of focal cerebral lesions in 12 infants (3 were classifi ... Full text Link to item Cite

Neuroprotective effect of felbamate after kainic acid-induced status epilepticus.

Journal article Epilepsia · 1993 Featured Publication Felbamate (FBM), a newly developed antiepileptic drug (AED), was previously shown to offer some neuroprotective effects against hypoxic injury in both in vivo and in vitro studies. We administered FBM (100 or 300 mg/kg) to 30-day-old rats 1 h after they re ... Full text Link to item Cite

A syndrome of autosomal dominant alternating hemiplegia: clinical presentation mimicking intractable epilepsy; chromosomal studies; and physiologic investigations.

Journal article Neurology · December 1992 Featured Publication We report the familial occurrence and apparent autosomal dominant inheritance of alternating hemiplegia of childhood. The proband, a 9-year-old boy, presented with developmental retardation, rare tonic-clonic seizures, and frequent episodes of flaccid alte ... Full text Link to item Cite

A nineteen-year-old man with altered mental status.

Journal article J Clin Pharmacol · June 1992 Featured Publication Full text Link to item Cite

Effect of high doses of intravenously administered immune globulin on natural killer cell activity in peripheral blood.

Journal article J Pediatr · March 1992 Featured Publication Because Kawasaki disease is a disorder characterized by lymphocyte activation and immune complex destruction of endothelial cells, we examined the effect of administration of high doses of intravenously administered immune globulin (IVIG) on a lymphocyte p ... Full text Link to item Cite

Double-blind randomized study comparing brand-name and generic phenytoin monotherapy.

Journal article Epilepsia · 1992 Featured Publication Ten patients with well-controlled seizures receiving chronic phenytoin (PHT) monotherapy for seizure prophylaxis completed a randomized double-blind crossover study comparing brand-name and generic PHT. Each patient received the same dose of each preparati ... Full text Link to item Cite

Delayed oculogyric crises associated with striatocapsular infarction.

Journal article J Clin Neuroophthalmol · September 1991 Featured Publication Oculogyric crises are dystonic, usually upward, conjugate eye deviations. We describe an 11-year-old girl who developed oculogyric crises 3 1/2 years after infarction of the right caudate, putamen, and internal capsule. Her abnormal eye movements responded ... Link to item Cite

Pyridoxine-dependent epilepsy: EEG investigations and long-term follow-up.

Journal article Electroencephalogr Clin Neurophysiol · March 1991 Featured Publication The EEG features and clinical correlates were investigated before, directly after, and on long-term follow-up after initiation of pyridoxine therapy in 6 patients with B6-dependent epilepsy. At each phase, the EEG provided important diagnostic and prognost ... Full text Link to item Cite

The newer antiepileptic drugs: carbamazepine and valproic acid.

Journal article Pediatr Ann · January 1991 Featured Publication Full text Link to item Cite

Neonatal herpes simplex meningoencephalitis: EEG investigations and clinical correlates.

Journal article Neurology · September 1990 Featured Publication We studied the sequential EEGs of 15 neonatal herpes simplex virus meningoencephalitis (NHSV-ME) patients and correlated them with corresponding clinical and laboratory findings. During days 1 to 4 of the illness, 8 had EEGs. All but 1 had abnormal tracing ... Full text Link to item Cite

Approach to epilepsy in children.

Journal article Indian J Pediatr · 1990 Featured Publication Full text Link to item Cite

Long-term tolerability, pharmacokinetic and preliminary efficacy study of lamotrigine in patients with resistant partial seizures.

Journal article Clin Neuropharmacol · August 1989 Featured Publication Four adult men with resistant partial seizures underwent an intensive open-label protocol designed to evaluate long-term add-on lamotrigine (LTG) therapy. Following an 8-week baseline, LTG was added to their background medication(s) (carbamazepine in three ... Full text Link to item Cite

Time course of carbamazepine autoinduction. The VA Cooperative Study No.118 Group.

Journal article Neurology · April 1989 Featured Publication We sequentially determined carbamazepine clearance values in 17 patients at the end of weeks 1, 2, 4, 8, and 12 of monotherapy. There were no significant differences among these clearance values. In 11 of 17 patients, week 1 clearance accurately predicted ... Full text Link to item Cite

Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance.

Journal article Neurology · July 1988 Featured Publication Addition of carbamazepine to phenytoin monotherapy resulted in the following significant (p less than 0.05) changes: (1) increased mean phenytoin serum concentration; (2) decreased phenytoin clearance, due to decreased production of phenytoin dihydrodiol a ... Full text Link to item Cite

Phenobarbital does not alter phenytoin steady-state serum concentration or pharmacokinetics.

Journal article Neurology · April 1988 Featured Publication Phenytoin pharmacokinetics and biotransformation were studied with stable isotope tracer techniques in six patients before and after addition of phenobarbital. No significant (p less than 0.05) changes in phenytoin serum concentration, clearance, eliminati ... Full text Link to item Cite

Comparative efficacy of antiepileptic drugs.

Journal article Clin Neuropharmacol · April 1988 Featured Publication Full text Link to item Cite

Bilateral total corneal and conjunctival choristomas associated with epidermal nevus.

Journal article Arch Ophthalmol · February 1986 Featured Publication A 4-year-old boy had been noted from birth to have bilateral masses obscuring the entire outer portion of the eyes. Systemic findings included mild growth retardation, multiple cortical lesions of the distal metaphyseal ends of the lower extremities, and d ... Full text Link to item Cite

Microcephaly, hypergonadotropic hypogonadism, short stature, and minor anomalies: a new syndrome.

Journal article Am J Med Genet · November 1985 Featured Publication Four sibs, three males and one female, had microcephaly, hypergonadotropic hypogonadism, short stature, and multiple congenital anomalies. They had five normal sibs and consanguineous parents. Findings in the affected sibs also included a narrow forehead, ... Full text Link to item Cite

Hypoglycorrhachia in neonatal herpes simplex virus meningoencephalitis.

Journal article J Pediatr · November 1985 Featured Publication Full text Link to item Cite

Childhood Guillain-Barré syndrome masquerading as a protracted pain syndrome.

Journal article Arch Neurol · September 1985 Featured Publication Full text Link to item Cite

Familial spinocerebellar degeneration with corneal dystrophy.

Journal article Am J Med Genet · February 1985 Featured Publication We report on two sisters born to normal but consanguineous parents, with the unusual combination of spinocerebellar degeneration and corneal dystrophy. Their manifestations include mental subnormality, bilateral corneal opacification starting in the second ... Full text Link to item Cite

Protracted epileptiform encephalopathy: an unusual form of partial complex status epilepticus.

Journal article Epilepsia · 1985 Featured Publication An 11-year-old previously healthy boy had an abrupt onset of partial complex, focal, multifocal, and generalized seizures, with interictal expressive aphasia, extreme emotional lability, agitation, and complex visual and auditory hallucinations. EEGs showe ... Full text Link to item Cite

Renal tubular insufficiency, cholestatic jaundice, and multiple congenital anomalies--a new multisystem syndrome.

Journal article Helv Paediatr Acta · December 1984 Featured Publication We are describing two male siblings with proximal renal tubular insufficiency, cholestatic jaundice, predisposition to infection, and multiple congenital anomalies. These patients presented in the early neonatal period with micrognathia, low set ears, high ... Link to item Cite

Hypertension encephalopathy: rare complication after orthopedic manipulation.

Journal article Am J Dis Child · December 1982 Featured Publication Full text Link to item Cite

Maple syrup urine disease with increased intracranial pressure.

Journal article Am J Dis Child · July 1982 Featured Publication Full text Link to item Cite

Brief clinical report and review: the Marden-Walker syndrome.

Journal article Am J Med Genet · March 1982 Featured Publication We have studied a sibship with one confirmed and three probable cases of the Marden-Walker syndrome (MWS). Our patient had the major manifestations of blepharophimosis and squint; narrowly arched palate with micrognathia; small mouth and mouth-breathing; f ... Full text Link to item Cite

The syndrome of hyperostosis and hyperphosphatemia.

Journal article J Pediatr · December 1981 Featured Publication Six children, five girls and one boy, presented with recurrent episodes of swelling, pain, and tenderness of the long bones. On roentgenographic examination all had cortical hyperostosis of the affected areas. Serum phosphate concentration was persistently ... Full text Link to item Cite