Scholars@Duke
Samsul Alam

Scholarly Works

Longitudinal Evaluation of an Abbreviated Patient-Reported Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) for Predicting Dopaminergic Therapy Initiation in Early Parkinson's Disease.

Journal article Mov Disord · February 2026 BACKGROUND: Predicting initiation of dopaminergic therapy in early Parkinson's disease (PD) is important for clinical management and trial design. Prior cross-sectional work identified a six-item patient-reported subset from the Movement Disorder Society-s ... Full text Open Access Link to item Cite

Joint modeling of high-dimensional longitudinal data and survival using supervised low-rank tensor decomposition.

Journal article Biostatistics · January 20, 2026 High-dimensional longitudinal data are increasingly available in biomedical research, especially from omics platforms, but pose substantial challenges for joint modeling with survival outcomes. These challenges include modeling complex temporal dynamics, a ... Full text Link to item Cite

Dynamic Prediction Using Functional Latent Trait Joint Models for Multivariate Longitudinal Outcomes: An Application to Parkinson's Disease.

Journal article Stat Med · October 2025 The progressive and multifaceted nature of Parkinson's disease (PD) calls for the integration of diverse data types, including continuous, ordinal, and binary, in longitudinal studies for a comprehensive understanding of symptom progression and disease tra ... Full text Open Access Link to item Cite

Integrative Multi-Omics and Multivariate Longitudinal Data Analysis for Dynamic Risk Estimation in Alzheimer's Disease.

Journal article Stat Med · May 2025 Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder, characterized by diverse cognitive and functional impairments that manifest heterogeneously across individuals, domains, and time. The accurate assessment of AD's severity an ... Full text Open Access Link to item Cite

Modeling longitudinal skewed functional data.

Journal article Biometrics · October 2024 This paper introduces a model for longitudinal functional data analysis that accounts for pointwise skewness. The proposed procedure decouples the marginal pointwise variation from the complex longitudinal and functional dependence using copula methodology ... Full text Cite