Scholars@Duke
David Charles Montefiori

David Charles Montefiori

Professor in Surgery
Surgery, Surgical Sciences
monte@duke.edu
Box 2926 Med Ctr, Durham, NC
Surgical Oncology Res Fac, Durham, NC 27710

Scholarly Works - Conferences

Mechanisms of early-life immunity associated with induction of heterologous HIV-1 neutralizing antibodies 9283

Conference The Journal of Immunology · November 1, 2025 Abstract Description A goal of an HIV-1 vaccine is induction of broadly neutralizing antibodies (bnAbs) that prevent infection ... Full text Cite

Recombinant MVA-prime elicits neutralizing antibody responses by inducing antigen-specific B cells in the germinal center

Conference Npj Vaccines · December 1, 2021 The RV144 HIV-1 vaccine trial has been the only clinical trial to date that has shown any degree of efficacy and associated with the presence of vaccine-elicited HIV-1 envelope-specific binding antibody and CD4+ T-cell responses. This trial also showed tha ... Full text Cite

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

Conference Nature Communications · December 1, 2019 Stabilized HIV-1 envelope glycoproteins (Env) that resemble the native Env are utilized in vaccination strategies aimed at inducing broadly neutralizing antibodies (bNAbs). To limit the exposure of rare isolate-specific antigenic residues/determinants we g ... Full text Cite

Priming with a Potent HIV-1 DNA Vaccine Frames the Quality of Immune Responses prior to a Poxvirus and Protein Boost.

Conference J Virol · February 1, 2019 The use of heterologous immunization regimens and improved vector systems has led to increases in immunogenicity of HIV-1 vaccine candidates in nonhuman primates. In order to resolve interrelations between different delivery modalities, three different pox ... Full text Link to item Cite

Germline-targeting and Reverse Engineering to Elicit CH235.12 Lineage bNAbs

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Bridging Vaccine-induced Antibody Responses in Rabbit and Rhesus Macaque Animal Models

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

Higher HIV Neutralization Breadth in Young Children Than in Chronically Infected Adults

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

A Phase 1 Trial of AAV1 Vectored Immunoprophylaxis for HIV

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2018 Link to item Cite

HIV Neutralizing Antibody Sensitivity/Resistance Signatures and Applications

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 2016 Link to item Cite

Antibodies for Prevention of Subtype A, C & D HIV-1 Infection

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 2016 Link to item Cite

Tier 1 Strains of HIV-1: Time to Break an Old Habit?

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 2016 Link to item Cite

D-102 Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

Conference JAIDS Journal of Acquired Immune Deficiency Syndromes · January 2016 Full text Cite

IN VIVO EVALUATION OF A NOVEL VARIANT OF SIVMAC LACKING CD4 TROPISM

Conference JOURNAL OF MEDICAL PRIMATOLOGY · October 1, 2014 Link to item Cite

Vaccine Induced Responses in a SIV Model Can Impact Challenge Outcomes

Conference AIDS Research and Human Retroviruses · October 2014 Full text Cite

Heterogeneity of Anti-V2 ADCC Ab Responses and Implications for Vaccine Development

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · November 1, 2013 Link to item Cite

Genetic and Immunological Evidence for a Role of Env-V3 Antibodies in the RV144 Trial

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · November 1, 2013 Link to item Cite

Human HIV-1 Vaccine Induced Antibody Durability and Env IgG3 Responses

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · November 1, 2013 Link to item Cite

Increased HIV-1 Immunogenicity of Replication Competent NYVAC

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · November 1, 2013 Link to item Cite

Comparison of systemic and mucosal responses after DNA and protein co-immunization

Conference JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES · April 1, 2013 Link to item Cite

Magnitude, Breadth and Duration of HIV-1 Vaccine-Elicited Neutralizing Antibody Responses

Conference JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES · April 1, 2013 Link to item Cite

Detection of CD4-Binding Site Antibodies in Three HIV-1 Seroconverter Cohorts

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2011 Link to item Cite

Generating Viruses Matching RV144 Vaccine Components to Explore Efficacy

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2011 Link to item Cite

Development of New Virologic Reagents: Improved Immune Monitoring Tools and Assays

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2010 Link to item Cite

Global B cell Profile of HIV Patients with Broadly Neutralizing Antibodies

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 2010 Link to item Cite

New broadly neutralizing human monoclonal antibodies targeting the 2F5 epitope

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2010 Link to item Cite

Limited introductions and genetic variation of HIV-1 in a MSM cohort in China

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2010 Link to item Cite

Vaccine-Elicited IgG Subclasses and Functional Antibodies

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2010 Link to item Cite

Magnitude and Breadth of the Neutralizing Antibody Response in RV144

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2010 Link to item Cite

Generation of potent CD4i-antibodies using gp140-CD4 miniprotein complex

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2010 Link to item Cite

Decrease in the Ratio of Infectious to Total Virions During Acute HIV-1 Infection

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2010 Link to item Cite

Improved DNA vaccination achieves long-lasting immune responses in macaques

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2010 Link to item Cite

Epitope Specificities of Elite Neutralizing Sera from HIV-1-Infected Individuals

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2010 Link to item Cite

Lupus Antibody Fragments to HIV gp120 Superantigenic Site

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 2008 Link to item Cite

Immunogenicity and Neutralization Properties of a Trimeric MPER Containing gp41 Antigen

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · October 1, 2008 Link to item Cite

GM-CSF as an adjuvant for protective immune responses

Conference JOURNAL OF MEDICAL PRIMATOLOGY · August 1, 2007 Link to item Cite

Immunization with HIV-1 gp160 by the ''prime and boost'' regimen protects macaques against SHIV HXBc2 challenge

Conference VACCINES 97 - MOLECULAR APPROACHES TO THE CONTROL OF INFECTIOUS DISEASES · January 1, 1997 Link to item Cite

A molecularly cloned, pathogenic, neutralization-resistant simian immunodeficiency virus, SIVsmE543-3

Conference VACCINES 97 - MOLECULAR APPROACHES TO THE CONTROL OF INFECTIOUS DISEASES · January 1, 1997 Link to item Cite

Role of complement in HIV and SIV pathogenesis and immunity

Conference SYMPOSIUM IN IMMUNOLOGY V · January 1, 1996 Link to item Cite

WHAT IS THE FATE OF COMPLEMENT-OPSONIZED HIV

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · January 1, 1995 Link to item Cite

SIV PATHOGENESIS DURING ONTOGENY - THE VIRUS THRESHOLD HYPOTHESIS

Conference AIDS RESEARCH AND HUMAN RETROVIRUSES · January 1, 1995 Link to item Cite

COMPLEMENT-MEDIATED BINDING OF HIV-1 TO CR-1 AND CR-2

Conference JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY · June 1, 1993 Link to item Cite

ISOLATION AND QUANTITATION OF EIF-4E IN H-9 LYMPHOCYTES

Conference CLINICAL RESEARCH · April 1, 1989 Link to item Cite

NATURAL-KILLER-CELL INFECTION AND INACTIVATION INVITRO BY HTLV-III LAV

Conference JOURNAL OF CELLULAR BIOCHEMISTRY · January 1, 1986 Link to item Cite