Scholars@Duke
David Charles Montefiori

David Charles Montefiori

Professor in Surgery
Surgery, Surgical Sciences
monte@duke.edu
Box 2926 Med Ctr, Durham, NC
Surgical Oncology Res Fac, Durham, NC 27710

Scholarly Works - Preprints

Functional Convergence of Genetically Diverse B-Cell Receptors in Simian-HIV Infected Rhesus Macaques.

Preprint · January 12, 2026 Germline-targeting or lineage-design vaccine strategies are being used to induce HIV broadly neutralizing antibody (bnAb) responses. These strategies assume that genetically diverse individuals respond similarly to the same immunogen by mobilizing comparab ... Full text Link to item Cite

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

Preprint · June 26, 2022 Abstract SARS-CoV-2 Omicron variants have generated a world-wide health crisis due to resistance to most approved SARS-CoV-2 neutralizing antibodies and evasion of antibodies induced by va ... Full text Cite

Structural diversity of the SARS-CoV-2 Omicron spike.

Preprint · January 26, 2022 Aided by extensive spike protein mutation, the SARS-CoV-2 Omicron variant overtook the previously dominant Delta variant. Spike conformation plays an essential role in SARS-CoV-2 evolution via changes in receptor binding domain (RBD) and neutralizing antib ... Full text Link to item Cite