Current Appointments & Affiliations
Research Technician II
Integrative Immunobiology,
Basic Science Departments
Recent Publications
Cellular RNA interacts with MAVS to promote antiviral signaling.
Journal Article Science · December 20, 2024 Antiviral signaling downstream of RIG-I-like receptors (RLRs) proceeds through a multi-protein complex organized around the adaptor protein mitochondrial antiviral signaling protein (MAVS). Protein complex function can be modulated by RNA molecules that pr ... Full text Link to item CiteSignaling from the RNA sensor RIG-I is regulated by ufmylation.
Journal Article Proc Natl Acad Sci U S A · April 12, 2022 The RNA-binding protein RIG-I is a key initiator of the antiviral innate immune response. The signaling that mediates the antiviral response downstream of RIG-I is transduced through the adaptor protein MAVS and results in the induction of type I and III i ... Full text Open Access Link to item CiteFTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression.
Journal Article J Mol Biol · March 30, 2022 Signaling initiated by type I interferon (IFN) results in the induction of hundreds of IFN-stimulated genes (ISGs). The type I IFN response is important for antiviral restriction, but aberrant activation of this response can lead to inflammation and autoim ... Full text Link to item CiteRecent Grants
Microbial regulation of intestinal epithelial gene expression
ResearchResearch Technician II · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2024 - 2028Defining the role of the RNA modification N6-methyladenosine during Flaviviridae virus infection
ResearchResearch Technician II · Awarded by National Institute of Allergy and Infectious Diseases · 2016 - 2027Regulation of RIG-I signaling and viral immune evasion by ufmylation
ResearchResearch Technician II · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026View All Grants