Skip to main content

Moria Joy Smoski

Associate Professor in Psychiatry and Behavioral Sciences
Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychology
Box 102505 Med Ctr, Durham, NC 27710
2400 Pratt St, North Pavilion Room 6045, Durham, NC 27705

Featured Works


Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerability.

Journal article Soc Cogn Affect Neurosci · January 2013 Featured Publication Mindfulness-based interventions are effective for reducing depressive symptoms. However, the psychological and neural mechanisms are unclear. This study examined which facets of trait mindfulness offer protection against negative bias and rumination, which ... Full text Link to item Cite

Association of Five-Factor Model Personality Domains and Facets with Presence, Onset, and Treatment Outcomes of Major Depression in Older Adults.

Journal article Am J Geriatr Psychiatry · March 15, 2012 Featured Publication OBJECTIVES:: To assess the relationship of multiple domains and facets of the five-factor model of personality with presence, onset, and severity of late-life depression. DESIGN:: Cross-sectional analysis of depression status, and age of onset. Retrospecti ... Full text Link to item Cite

Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes.

Journal article J Affect Disord · February 2012 Featured Publication BACKGROUND: Although functional brain imaging has established that individuals with unipolar major depressive disorder (MDD) are characterized by frontostriatal dysfunction during reward processing, no research to date has examined the chronometry of neura ... Full text Link to item Cite

Major depressive disorder is characterized by greater reward network activation to monetary than pleasant image rewards.

Journal article Psychiatry Res · December 30, 2011 Featured Publication Anhedonia, the loss of interest or pleasure in normally rewarding activities, is a hallmark feature of unipolar Major Depressive Disorder (MDD). A growing body of literature has identified frontostriatal dysfunction during reward anticipation and outcomes ... Full text Link to item Cite

Changes in spirituality partly explain health-related quality of life outcomes after Mindfulness-Based Stress Reduction.

Journal article J Behav Med · December 2011 Featured Publication Mindfulness-Based Stress Reduction is a secular behavioral medicine program that has roots in meditative spiritual practices. Thus, spirituality may partly explain Mindfulness-Based Stress Reduction outcomes. Participants (N = 279; M (SD) age = 45(12); 75% ... Full text Link to item Cite

Effects of mindfulness on psychological health: a review of empirical studies.

Journal article Clin Psychol Rev · August 2011 Featured Publication Within the past few decades, there has been a surge of interest in the investigation of mindfulness as a psychological construct and as a form of clinical intervention. This article reviews the empirical literature on the effects of mindfulness on psycholo ... Full text Link to item Cite

Functional imaging of emotion reactivity in opiate-dependent borderline personality disorder.

Journal article Personal Disord · July 2011 Featured Publication Opiate dependence (OD) and borderline personality disorder (BPD), separately and together, are significant public health problems with poor treatment outcomes. BPD is associated with difficulties in emotion regulation, and brain-imaging studies in BPD indi ... Full text Link to item Cite

The effects of Brief Behavioral Activation Therapy for Depression on cognitive control in affective contexts: An fMRI investigation.

Journal article J Affect Disord · October 2010 Featured Publication BACKGROUND: Unipolar major depressive disorder (MDD) is characterized by impaired cognitive control in affective contexts, but the potential for psychotherapy to affect the neural correlates of these functions has not been evaluated. METHOD: Twelve adults ... Full text Link to item Cite

Staying cool when things get hot: emotion regulation modulates neural mechanisms of memory encoding.

Journal article Front Hum Neurosci · 2010 Featured Publication During times of emotional stress, individuals often engage in emotion regulation to reduce the experiential and physiological impact of negative emotions. Interestingly, emotion regulation strategies also influence memory encoding of the event. Cognitive r ... Full text Open Access Link to item Cite

The effects of psychotherapy on neural responses to rewards in major depression.

Journal article Biol Psychiatry · November 1, 2009 Featured Publication BACKGROUND: Unipolar major depressive disorder (MDD) is characterized by anomalous neurobiological responses to pleasant stimuli, a pattern that may be linked to symptoms of anhedonia. However, the potential for psychotherapy to normalize neurobiological r ... Full text Link to item Cite

fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder.

Journal article J Affect Disord · November 2009 Featured Publication The purpose of the present investigation was to evaluate reward processing in unipolar major depressive disorder (MDD). Specifically, we investigated whether adults with MDD demonstrated hyporesponsivity in striatal brain regions and/or hyperresponsivity i ... Full text Link to item Cite

Affective context interferes with cognitive control in unipolar depression: an fMRI investigation.

Journal article J Affect Disord · April 2009 Featured Publication BACKGROUND: Unipolar major depressive disorder (MDD) is characterized by aberrant amygdala responses to sad stimuli and poor cognitive control, but the interactive effects of these impairments are poorly understood. AIM: To evaluate brain activation in MDD ... Full text Link to item Cite

Decision-making and risk aversion among depressive adults.

Journal article J Behav Ther Exp Psychiatry · December 2008 Featured Publication Depression is associated with behavioral avoidance of potentially rewarding environmental contexts. The present study examined the performance of depressive individuals and controls on a neuropsychological measure of decision-making that favors risk avoida ... Full text Link to item Cite

Prefrontal mechanisms for executive control over emotional distraction are altered in major depression.

Journal article Psychiatry Res · July 15, 2008 Featured Publication A dysfunction in the interaction between executive function and mood regulation has been proposed as the pathophysiology of depression. However, few studies have investigated the alteration in brain systems related to executive control over emotional distr ... Full text Link to item Cite