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Prithvi Mruthyunjaya

Adjunct Associate Professor in the Department of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery
Box 3802 Med Ctr, Durham, NC 27710
Dept of Ophthalmology, Durham, NC 27710

Selected Publications


An Unusual Pigmented Lesion.

Journal Article Ophthalmology · February 28, 2024 Full text Link to item Cite

Association of Ocular Manifestations of Marfan Syndrome With Cardiovascular Complications.

Journal Article Am J Ophthalmol · February 23, 2024 PURPOSE: To evaluate associations between ocular manifestations of Marfan syndrome and cardiovascular complications. DESIGN: Retrospective cohort study. METHODS: The TriNetX Analytics platform, a federated health research network of aggregated deidentified ... Full text Link to item Cite

Liquid Biopsy Proteomics in Ophthalmology.

Journal Article J Proteome Res · February 2, 2024 Minimally invasive liquid biopsies from the eye capture locally enriched fluids that contain thousands of proteins from highly specialized ocular cell types, presenting a promising alternative to solid tissue biopsies. The advantages of liquid biopsies inc ... Full text Link to item Cite

Association of Cutaneous Keloids, Hypertrophic Scarring, and Fibrosis with Risk of Postoperative Proliferative Vitreoretinopathy.

Journal Article Ophthalmology · February 1, 2024 PURPOSE: To assess an association between cutaneous keloids, hypertrophic scarring, and fibrosis (KHF) and risk of postoperative proliferative vitreoretinopathy (PVR) after rhegmatogenous retinal detachment (RRD) repair. DESIGN: Retrospective, population-b ... Full text Link to item Cite

Risk of Stroke, Myocardial Infarction, Deep Vein Thrombosis, Pulmonary Embolism, and Death After Retinal Vein Occlusion.

Journal Article Am J Ophthalmol · January 2024 PURPOSE: To examine rates of stroke, myocardial infarction (MI), deep vein thrombosis (DVT), pulmonary embolism (PE), and death in patients after retinal vein occlusion (RVO) compared to controls. DESIGN: Retrospective cohort study. METHODS: An aggregated ... Full text Link to item Cite

AI-Human Hybrid Workflow Enhances Teleophthalmology for the Detection of Diabetic Retinopathy.

Journal Article Ophthalmol Sci · December 2023 OBJECTIVE: Detection of diabetic retinopathy (DR) outside of specialized eye care settings is an important means of access to vision-preserving health maintenance. Remote interpretation of fundus photographs acquired in a primary care or other nonophthalmi ... Full text Link to item Cite

Risk of Stroke, Myocardial Infarction, and Death After Retinal Artery Occlusion.

Journal Article JAMA Ophthalmol · December 1, 2023 IMPORTANCE: Patients with retinal artery occlusions (RAOs) are recommended to have emergent stroke workup, although the true risk of death and subsequent vascular events post-RAO is not clear. OBJECTIVE: To determine short-term and long-term rates of strok ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · November 2023 Full text Link to item Cite

Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers.

Journal Article Invest Ophthalmol Vis Sci · November 1, 2023 PURPOSE: The purpose of this study was to profile protein expression liquid vitreous biopsies from patients with uveal melanoma (UM) using mass spectrometry to identify prognostic biomarkers, signaling pathways, and therapeutic targets. METHODS: Vitreous b ... Full text Link to item Cite

Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo.

Journal Article Cell · October 26, 2023 Single-cell analysis in living humans is essential for understanding disease mechanisms, but it is impractical in non-regenerative organs, such as the eye and brain, because tissue biopsies would cause serious damage. We resolve this problem by integrating ... Full text Link to item Cite

The Biosimilar Paradox: How Anti-Vascular Endothelial Growth Factor Biosimilars Could Increase Patient and Overall Health Care Costs.

Journal Article Ophthalmology · September 2023 PURPOSE: Anti-vascular endothelial growth factor (VEGF) medications for intraocular use are a major and increasing cost, and biosimilars may be a means of reducing the high cost of many biologic medications. However, a bevacizumab biosimilar, which is curr ... Full text Link to item Cite

Endoscopic enucleation and clinicopathologic correlation of a small choroidal melanoma hiding massive extrascleral extension.

Journal Article Am J Ophthalmol Case Rep · March 2023 PURPOSE: To report the unusual case of a previously stable choroidal nevus, closely followed for over 15 years, which underwent malignant transformation into small choroidal melanoma with massive extrascleral extension. OBSERVATIONS: A 67-year-old Caucasia ... Full text Link to item Cite

Radio-luminescent imaging for rapid, high-resolution eye plaque loading verification.

Conference Med Phys · January 2023 BACKGROUND: Eye plaque brachytherapy is currently an optimal therapy for intraocular cancers. Due to the lack of an effective and practical technique to measure the seed radioactivity distribution, current quality assurance (QA) practice according to the A ... Full text Link to item Cite

Intraoperative Complications With Vitreous Biopsy for Molecular Proteomics.

Journal Article Ophthalmic Surg Lasers Imaging Retina · January 2023 OBJECTIVE: To study the incidence of intraoperative complications while collecting a vitreous sample for proteomic biomarker analyses during small-gauge pars plana vitrectomy (PPV). METHODS: A retrospective case series was assembled from the surgical logs ... Full text Link to item Cite

Private equity in ophthalmology and optometry: a time series analysis from 2012 to 2021.

Journal Article Digit J Ophthalmol · 2023 PURPOSE: To identify temporal and geographic trends in private equity (PE)-backed acquisitions of ophthalmology and optometry practices in the United States from 2012 to 2021. METHODS: In this cross-sectional time series, acquisition data from 10/21/2019 t ... Full text Link to item Cite

Artificial Intelligence Improves Patient Follow-Up in a Diabetic Retinopathy Screening Program.

Journal Article Clin Ophthalmol · 2023 PURPOSE: We examine the rate of and reasons for follow-up in an Artificial Intelligence (AI)-based workflow for diabetic retinopathy (DR) screening relative to two human-based workflows. PATIENTS AND METHODS: A DR screening program initiated September 2019 ... Full text Link to item Cite

An Unusual Pigmented Lesion.

Journal Article Ophthalmology · February 28, 2024 Full text Link to item Cite

Association of Ocular Manifestations of Marfan Syndrome With Cardiovascular Complications.

Journal Article Am J Ophthalmol · February 23, 2024 PURPOSE: To evaluate associations between ocular manifestations of Marfan syndrome and cardiovascular complications. DESIGN: Retrospective cohort study. METHODS: The TriNetX Analytics platform, a federated health research network of aggregated deidentified ... Full text Link to item Cite

Liquid Biopsy Proteomics in Ophthalmology.

Journal Article J Proteome Res · February 2, 2024 Minimally invasive liquid biopsies from the eye capture locally enriched fluids that contain thousands of proteins from highly specialized ocular cell types, presenting a promising alternative to solid tissue biopsies. The advantages of liquid biopsies inc ... Full text Link to item Cite

Association of Cutaneous Keloids, Hypertrophic Scarring, and Fibrosis with Risk of Postoperative Proliferative Vitreoretinopathy.

Journal Article Ophthalmology · February 1, 2024 PURPOSE: To assess an association between cutaneous keloids, hypertrophic scarring, and fibrosis (KHF) and risk of postoperative proliferative vitreoretinopathy (PVR) after rhegmatogenous retinal detachment (RRD) repair. DESIGN: Retrospective, population-b ... Full text Link to item Cite

Risk of Stroke, Myocardial Infarction, Deep Vein Thrombosis, Pulmonary Embolism, and Death After Retinal Vein Occlusion.

Journal Article Am J Ophthalmol · January 2024 PURPOSE: To examine rates of stroke, myocardial infarction (MI), deep vein thrombosis (DVT), pulmonary embolism (PE), and death in patients after retinal vein occlusion (RVO) compared to controls. DESIGN: Retrospective cohort study. METHODS: An aggregated ... Full text Link to item Cite

AI-Human Hybrid Workflow Enhances Teleophthalmology for the Detection of Diabetic Retinopathy.

Journal Article Ophthalmol Sci · December 2023 OBJECTIVE: Detection of diabetic retinopathy (DR) outside of specialized eye care settings is an important means of access to vision-preserving health maintenance. Remote interpretation of fundus photographs acquired in a primary care or other nonophthalmi ... Full text Link to item Cite

Risk of Stroke, Myocardial Infarction, and Death After Retinal Artery Occlusion.

Journal Article JAMA Ophthalmol · December 1, 2023 IMPORTANCE: Patients with retinal artery occlusions (RAOs) are recommended to have emergent stroke workup, although the true risk of death and subsequent vascular events post-RAO is not clear. OBJECTIVE: To determine short-term and long-term rates of strok ... Full text Link to item Cite

Reply.

Journal Article Ophthalmology · November 2023 Full text Link to item Cite

Cross-Platform Identification and Validation of Uveal Melanoma Vitreous Protein Biomarkers.

Journal Article Invest Ophthalmol Vis Sci · November 1, 2023 PURPOSE: The purpose of this study was to profile protein expression liquid vitreous biopsies from patients with uveal melanoma (UM) using mass spectrometry to identify prognostic biomarkers, signaling pathways, and therapeutic targets. METHODS: Vitreous b ... Full text Link to item Cite

Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo.

Journal Article Cell · October 26, 2023 Single-cell analysis in living humans is essential for understanding disease mechanisms, but it is impractical in non-regenerative organs, such as the eye and brain, because tissue biopsies would cause serious damage. We resolve this problem by integrating ... Full text Link to item Cite

The Biosimilar Paradox: How Anti-Vascular Endothelial Growth Factor Biosimilars Could Increase Patient and Overall Health Care Costs.

Journal Article Ophthalmology · September 2023 PURPOSE: Anti-vascular endothelial growth factor (VEGF) medications for intraocular use are a major and increasing cost, and biosimilars may be a means of reducing the high cost of many biologic medications. However, a bevacizumab biosimilar, which is curr ... Full text Link to item Cite

Endoscopic enucleation and clinicopathologic correlation of a small choroidal melanoma hiding massive extrascleral extension.

Journal Article Am J Ophthalmol Case Rep · March 2023 PURPOSE: To report the unusual case of a previously stable choroidal nevus, closely followed for over 15 years, which underwent malignant transformation into small choroidal melanoma with massive extrascleral extension. OBSERVATIONS: A 67-year-old Caucasia ... Full text Link to item Cite

Radio-luminescent imaging for rapid, high-resolution eye plaque loading verification.

Conference Med Phys · January 2023 BACKGROUND: Eye plaque brachytherapy is currently an optimal therapy for intraocular cancers. Due to the lack of an effective and practical technique to measure the seed radioactivity distribution, current quality assurance (QA) practice according to the A ... Full text Link to item Cite

Intraoperative Complications With Vitreous Biopsy for Molecular Proteomics.

Journal Article Ophthalmic Surg Lasers Imaging Retina · January 2023 OBJECTIVE: To study the incidence of intraoperative complications while collecting a vitreous sample for proteomic biomarker analyses during small-gauge pars plana vitrectomy (PPV). METHODS: A retrospective case series was assembled from the surgical logs ... Full text Link to item Cite

Private equity in ophthalmology and optometry: a time series analysis from 2012 to 2021.

Journal Article Digit J Ophthalmol · 2023 PURPOSE: To identify temporal and geographic trends in private equity (PE)-backed acquisitions of ophthalmology and optometry practices in the United States from 2012 to 2021. METHODS: In this cross-sectional time series, acquisition data from 10/21/2019 t ... Full text Link to item Cite

Artificial Intelligence Improves Patient Follow-Up in a Diabetic Retinopathy Screening Program.

Journal Article Clin Ophthalmol · 2023 PURPOSE: We examine the rate of and reasons for follow-up in an Artificial Intelligence (AI)-based workflow for diabetic retinopathy (DR) screening relative to two human-based workflows. PATIENTS AND METHODS: A DR screening program initiated September 2019 ... Full text Link to item Cite

Impact of Early COVID-19 Pandemic on Common Ophthalmic Procedures Volumes: A US Claims-Based Analysis.

Journal Article Ophthalmic Epidemiol · December 2022 PURPOSE: The COVID-19 pandemic has had a profound effect on the delivery of healthcare in the United States and globally. The aim of this study was to evaluate the impact of COVID-19 on common ophthalmic procedure utilization and normalization to pre-pande ... Full text Link to item Cite

Applicant Characteristics Associated with Retina Fellowship Match from 2010-2019.

Journal Article Ophthalmol Retina · December 2022 OBJECTIVE: To describe trends in the surgical and medical retina fellowship match and applicant characteristics associated with matching in retina fellowship. DESIGN: Retrospective study. SUBJECTS: Ophthalmology fellowship applicants who applied through th ... Full text Link to item Cite

Intravitreal brolucizumab as treatment of early onset radiation retinopathy secondary to plaque brachytherapy for choroidal melanoma.

Journal Article Am J Ophthalmol Case Rep · September 2022 PURPOSE: To describe the efficacy and safety of brolucizumab (Beovu®, Novartis Pharmaceuticals) in a case of cystoid macular edema associated with radiation retinopathy as a result of iodine-125 plaque brachytherapy (PBT) for choroidal melanoma, resistant ... Full text Link to item Cite

Presumed bilateral diffuse uveal melanocytic proliferation - A case report and review of literature.

Journal Article Am J Ophthalmol Case Rep · September 2022 PURPOSE: To describe a case of presumed bilateral diffuse uveal melanocytic proliferation (BDUMP) associated with renal cell carcinoma (RCC) and provide an updated review of literature. OBSERVATIONS: A 58-year-old man, with a history of radical nephrectomy ... Full text Link to item Cite

Update in Molecular Testing for Intraocular Lymphoma.

Journal Article Cancers · September 2022 The diagnosis of primary vitreoretinal lymphoma and central nervous system lymphoma is challenging. In cases with intraocular involvement, vitreous biopsy plays a pivotal role. Several diagnostic tests are employed to confirm a diagnosis and include cytolo ... Full text Cite

Predicting Systemic Health Features from Retinal Fundus Images Using Transfer-Learning-Based Artificial Intelligence Models.

Journal Article Diagnostics (Basel) · July 14, 2022 While color fundus photos are used in routine clinical practice to diagnose ophthalmic conditions, evidence suggests that ocular imaging contains valuable information regarding the systemic health features of patients. These features can be identified thro ... Full text Link to item Cite

Vitreofoveal Traction Associated With Pilocarpine for Presbyopia.

Journal Article Ophthalmic Surg Lasers Imaging Retina · July 2022 Vuity (pilocarpine HCL ophthalmic 1.25%) was approved for the treatment of presbyopia in October 2021. Previous case series have reported the presence of vitreofoveal traction and retinal detachment following pilocarpine administration, but this was not re ... Full text Link to item Cite

Preferentially Expressed Antigen in Melanoma Immunohistochemistry Labeling in Uveal Melanomas.

Journal Article Ocul Oncol Pathol · June 2022 INTRODUCTION: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, and despite treatment of the primary tumor, approximately 15%-50% of patients will develop metastatic disease. Based on gene expression profiling (GEPs), UM can ... Full text Link to item Cite

Proteomics in uveal melanoma.

Journal Article Current opinion in ophthalmology · May 2022 Purpose of reviewThis article reviews the latest proteomic research on uveal melanoma.Recent findingsProteomic analysis of uveal melanoma cell lines and tissue specimens has improved our understanding of the pathophysiology of uveal melan ... Full text Cite

BILATERAL SERPIGINOUS-LIKE CHORIORETINITIS ASSOCIATED WITH CILIOCHOROIDAL MELANOMA: A Clinicopathologic Correlation.

Journal Article Retina · April 1, 2022 PURPOSE: To report the clinicopathologic correlation of a case of bilateral serpiginous-like chorioretinitis (SLC) associated with unilateral ciliochoroidal melanoma. METHODS: A 71-year-old white woman was diagnosed with progressive SLC in both eyes associ ... Full text Link to item Cite

Displacement of submacular hemorrhage with intravitreal tissue plasminogen activator following 27 gauge transvitreal fine needle aspiration biopsy for choroidal melanoma.

Journal Article Am J Ophthalmol Case Rep · March 2022 PURPOSE: To describe the management of submacular hemorrhage (SMH), a vision threatening complication following transvitreal choroidal biopsy, with intravitreal tissue plasminogen activator (tPA) and pure perfluoropropane (C3F8) gas bubble injection. OBSER ... Full text Link to item Cite

Multiple Genetically Distinct Uveal Melanomas Arise in the Same Eye of Two Patients with Melanosis Oculi.

Journal Article Am J Ophthalmol · February 2022 PURPOSE: To determine whether unilateral multifocal uveal melanomas (UM) in the setting of ocular melanosis (melanosis oculi) represent genetically independent tumors. DESIGN: Clinical case series. METHODS: Two patients with unilateral multifocal UM in the ... Full text Link to item Cite

Single-Blind and Double-Blind Peer Review: Effects on National Representation.

Journal Article Semin Ophthalmol · January 2, 2022 PURPOSE: To assess whether the type of peer-review (single-blinded vs double-blinded) has an impact on nationality representation in journals. METHODS: A cross-sectional study analyzing the top 10 nationalities contributing to the number of articles across ... Full text Link to item Cite

Discontinuation and loss to follow-up rates in clinical trials of intravitreal anti-vascular endothelial growth factor injections.

Journal Article Graefes Arch Clin Exp Ophthalmol · January 2022 PURPOSE: Clinical trials are often designed to include homogenous, highly specific patient populations with many resources to reduce patient dropout. Results may not translate to real-world settings. We evaluated discontinuation and loss to follow-up (LTFU ... Full text Link to item Cite

Intravitreal Pharmacotherapies for Diabetic Macular Edema: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · January 2022 PURPOSE: To review the evidence on the safety and efficacy of current anti-vascular endothelial growth factor (VEGF) and intravitreal corticosteroid pharmacotherapies for the treatment of diabetic macular edema (DME). METHODS: Literature searches were last ... Full text Link to item Cite

The Effect of Obstructive Sleep Apnea Treatment and Severity on Choroidal Thickness in Patients With Central Serous Chorioretinopathy.

Journal Article J Vitreoretin Dis · 2022 PURPOSE: This work aimed to analyze the association of obstructive sleep apnea (OSA) with choroidal thickness (CT) in patients with central serous chorioretinopathy (CSC). METHODS: We identified patients in the Stanford Research Repository with a diagnosis ... Full text Link to item Cite

Diagnostic and Therapeutic Challenges.

Journal Article Retina · September 1, 2021 Full text Link to item Cite

Comparing clinical outcomes of macular hole surgeries performed by trainee surgeons using a 3D heads-up display viewing system versus a standard operating microscope.

Journal Article Int Ophthalmol · August 2021 PURPOSE: To compare the surgical outcomes of macular hole (MH) surgery performed by trainee surgeons using a three-dimensional heads-up display (3D HUD) versus a standard operating microscope (SOM). MATERIALS AND METHODS: A retrospective review of all cons ... Full text Link to item Cite

Rates of Reoperation in 10 114 Patients with Epiretinal Membranes Treated by Vitrectomy with or without Inner Limiting Membrane Peeling.

Journal Article Ophthalmol Retina · July 2021 PURPOSE: To compare rates of reoperation in patients with idiopathic epiretinal membrane (ERM) who received pars plana vitrectomy (PPV) with or without inner limiting membrane (ILM) peeling and to assess trends in the overall use of ILM peeling over time. ... Full text Link to item Cite

Diagnostic and Therapeutic Challenges.

Journal Article Retina · June 1, 2021 Full text Link to item Cite

Metastasis of Lung Adenocarcinoma to the Lacrimal Sac.

Journal Article Ophthalmic Plast Reconstr Surg · May 2021 The authors report an unusual case of lung adenocarcinoma metastasis to the lacrimal sac. A 61-year-old woman with stage IV non-small cell lung cancer presented with left facial pain and epiphora. She was found to have an elevated tear meniscus associated ... Full text Link to item Cite

Response criteria for intraocular retinoblastoma: RB-RECIST.

Journal Article Pediatr Blood Cancer · May 2021 Standardized guidelines for assessing tumor response to therapy are essential for designing and conducting clinical trials. The Response Evaluation Criteria In Solid Tumors (RECIST) provide radiological standards for assessment of solid tumors. However, no ... Full text Link to item Cite

Anti-Vascular Endothelial Growth Factor and Panretinal Photocoagulation Use after Protocol S for Proliferative Diabetic Retinopathy.

Journal Article Ophthalmol Retina · February 2021 PURPOSE: To characterize the rates of panretinal photocoagulation (PRP) and anti-vascular endothelial growth factor (VEGF) medications before and after publication of the Diabetic Retinopathy Clinical Research Network protocol S. DESIGN: A retrospective, c ... Full text Link to item Cite

White Paper on Ophthalmic Imaging for Choroidal Nevus Identification and Transformation into Melanoma.

Journal Article Translational vision science & technology · February 2021 PurposeTo discuss the evolution of noninvasive diagnostic methods in the identification of choroidal nevus and determination of risk factors for malignant transformation as well as introduce the novel role that artificial intelligence (AI) can pla ... Full text Cite

Uveal Melanoma: Imaging

Chapter · January 1, 2021 Imaging plays an essential role in the diagnosis and management of intraocular uveal melanoma. Successful application of imaging will frequently involve multiple modalities, including color photography, ocular ultrasound, fluorescein angiography, and optic ... Full text Cite

"Giant cell arteritis manifesting as retinal arterial occlusion and paracentral acute middle maculopathy in a patient on pembrolizumab for metastatic uveal melanoma".

Journal Article Am J Ophthalmol Case Rep · December 2020 PURPOSE: To report the association of pembrolizumab, an immune checkpoint inhibitor (ICI), with giant cell arteritis (GCA) presenting as paracentral acute middle maculopathy (PAMM) secondary to retinal arterial occlusion. OBSERVATIONS: 86-year old male wit ... Full text Link to item Cite

Ophthalmic Medication Expenditures and Out-of-Pocket Spending: An Analysis of United States Prescriptions from 2007 through 2016.

Journal Article Ophthalmology · October 2020 PURPOSE: To estimate temporal trends in total and out-of-pocket (OOP) expenditures for ophthalmic prescription medications among adults in the United States. DESIGN: Retrospective, longitudinal cohort study. PARTICIPANTS: Participants in the 2007 through 2 ... Full text Link to item Cite

The Effect of Obstructive Sleep Apnea on Absolute Risk of Central Serous Chorioretinopathy.

Journal Article Am J Ophthalmol · October 2020 PURPOSE: To determine the incidence of central serous chorioretinopathy (CSC) stratified by age, sex, and diagnosis with obstructive sleep apnea (OSA), and to determine whether some patients with newly diagnosed CSC may be candidates for OSA evaluation. DE ... Full text Link to item Cite

Dosimetry modeling of focused kV x-ray radiotherapy for wet age-related macular degeneration.

Journal Article Med Phys · October 2020 PURPOSE: Wet (neovascular) age-related macular degeneration (AMD) is the leading cause of blindness in the United States. The mainstay treatment requires monthly intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs, associate ... Full text Link to item Cite

Rationale for American Society of Retina Specialists Best Practice Recommendations for Conducting Vitreoretinal Surgery during the COVID-19 Era.

Journal Article J Vitreoretin Dis · October 1, 2020 PURPOSE: To detail the rationale behind recommendations recently published by the American Society of Retina Specialists (ASRS) outlining best practices for safety of vitreoretinal surgeons and staff while performing vitreoretinal surgery during the corona ... Full text Link to item Cite

Evaluation of Racial, Ethnic, and Socioeconomic Associations With Treatment and Survival in Uveal Melanoma, 2004-2014.

Journal Article JAMA Ophthalmol · August 1, 2020 IMPORTANCE: Identifying disparities in uveal melanoma (UM) treatment patterns and survival across racial, ethnic, and socioeconomic (SES) groups reveals possible inequities in ophthalmologic health care. OBJECTIVE: To examine the association of race, ethni ... Full text Link to item Cite

Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5.

Journal Article Ocul Oncol Pathol · May 2020 BACKGROUND: Treatment planning for I-125 plaque therapy for uveal melanoma has advanced significantly since the Collaborative Ocular Melanoma Study trial, with more widely available image-guided planning and improved dosimetry. OBJECTIVE: We evaluated real ... Full text Link to item Cite

Global Retinoblastoma Presentation and Analysis by National Income Level.

Journal Article JAMA Oncol · May 1, 2020 IMPORTANCE: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presenta ... Full text Link to item Cite

Anti-Vascular Endothelial Growth Factor Therapy for Radiation Retinopathy.

Journal Article Ophthalmic Surg Lasers Imaging Retina · April 1, 2020 BACKGROUND AND OBJECTIVE: The purpose of this article is to review the role of anti-vascular endothelial growth factor (VEGF) therapy in treating patients with radiation retinopathy (RR). PATIENTS AND METHODS: RR can be associated with a significant decrea ... Full text Link to item Cite

Multi-center analysis of intraocular biopsy technique and outcomes for uveal melanoma: Ocular Oncology Study Consortium report 4.

Journal Article Graefes Arch Clin Exp Ophthalmol · February 2020 PURPOSE: To investigate the relationship between surgical approach for intraocular tumor biopsy of uveal melanoma and tumor morphologic features such as size and intraocular location and the effect of these variables on diagnostic yield and biopsy outcome. ... Full text Link to item Cite

Association of Rhegmatogenous Retinal Detachment and Outcomes With the Day of the Week That Patients Undergo a Repair or Receive a Diagnosis.

Journal Article JAMA Ophthalmol · February 1, 2020 IMPORTANCE: Because variation in care on weekends has been reported in many surgical fields, it is of interest if variations were noted for care patterns of rhegmatogenous retinal detachments (RRDs). OBJECTIVE: To assess the association between modality of ... Full text Link to item Cite

CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA.

Journal Article Retina · February 2020 PURPOSE: To study the relationship between gene expression profile (GEP) subclass and American Joint Committee on Cancer (AJCC) stage in patients with uveal melanoma (UM). METHODS: A retrospective, multicenter study was undertaken with patients entered fro ... Full text Link to item Cite

Pseudoprogression of Metastatic Melanoma to the Orbit With Pembrolizumab.

Journal Article Ophthalmic Plast Reconstr Surg · 2020 The management of metastatic melanoma to the orbit may involve a variety of therapeutic modalities including external-beam radiation, chemotherapy, and varying degrees of surgical resection or debulking. Pembrolizumab is an immunotherapeutic agent that has ... Full text Link to item Cite

Vitelliform Vitreoretinopathy: Clinical Implications of the Vitreomacular Interface.

Journal Article Oman J Ophthalmol · 2020 Pathologies of the vitreomacular interface are implicated in a variety of sight-threatening clinical entities. The authors present a photo essay of a case of Terson syndrome with a striking premacular dehemoglobinized hemorrhage with ovoid morphology. This ... Full text Link to item Cite

Racial, Ethnic, and Socioeconomic Disparities in Retinoblastoma Enucleation: A Population-Based Study, SEER 18 2000-2014.

Journal Article Am J Ophthalmol · November 2019 PURPOSE: To determine the effect of race, ethnicity, and census tract-level composite socioeconomic status (SES) on retinoblastoma enucleation. This study augments Truong and associates, providing multivariate analyses combining sociodemographic and clinic ... Full text Link to item Cite

RELATIONSHIP OF CLINICAL FEATURES AND BASELINE TUMOR SIZE WITH GENE EXPRESSION PROFILE STATUS IN UVEAL MELANOMA: A Multi-institutional Study.

Journal Article Retina · June 2019 PURPOSE: To study the relationship between gene expression profile subclass and clinical features in a multicenter cohort of patients with uveal melanoma. METHODS: A retrospective, multicenter study was undertaken with patients entered from nine major ocul ... Full text Link to item Cite

IDENTIFICATION OF POSTERIOR SEGMENT PATHOLOGY WITH EN FACE RETINAL IMAGING USING MULTICOLOR CONFOCAL SCANNING LASER OPHTHALMOSCOPY.

Journal Article Retina · May 2019 PURPOSE: To assess posterior segment findings on multicolor confocal scanning laser ophthalmoscopy by correlation with spectral domain optical coherence tomography (SD-OCT) and to quantify agreement between these imaging modalities. METHODS: Retrospective ... Full text Link to item Cite

Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump-Probe Microscopy.

Journal Article Transl Vis Sci Technol · May 2019 PURPOSE: We analyze melanin structure and biochemical composition in conjunctival melanocytic lesions using pump-probe microscopy to assess the potential for this method to assist in melanoma diagnosis. METHODS: Pump-probe microscopy interrogates transient ... Full text Link to item Cite

The Effect of Anti-Vascular Endothelial Growth Factor Agents on Intraocular Pressure and Glaucoma: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · April 2019 PURPOSE: To assess the effect of intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents on immediate and long-term intraocular pressure (IOP) elevation and glaucoma. METHODS: Literature searches of the PubMed and Cochrane database ... Full text Link to item Cite

Comparison of Optical Coherence Tomography With Fundus Photographs, Fluorescein Angiography, and Histopathologic Analysis in Assessing Coats Disease.

Journal Article JAMA Ophthalmol · February 1, 2019 IMPORTANCE: Coats disease is a rare pediatric vitreoretinopathy that can cause devastating visual and anatomic outcomes. OBJECTIVE: To compare optical coherence tomography (OCT) with fundus photographs, fluorescein angiography (FA), and histopathologic fin ... Full text Link to item Cite

Updates in imaging in ocular oncology.

Journal Article F1000Res · 2019 Innovations in ophthalmic imaging have made a profound impact on the diagnosis and treatment of ophthalmic disease. In ocular oncology, the development of optical coherence tomography with enhanced depth imaging and swept source technologies has made it po ... Full text Link to item Cite

Retinal metastatic tumors

Chapter · January 1, 2019 The most common form of intraocular malignancy is metastatic disease. The most common primary sites are the lung in men and the breast in women. Retinal metastases are much rarer than those in the choroid. Biopsy is useful for confirming the diagnosis and ... Full text Cite

Widefield imaging of retinal and choroidal tumors.

Journal Article Int J Retina Vitreous · 2019 BACKGROUND: Wide-field imaging plays an increasingly important role in ocular oncology clinics. The purpose of this review is to describe the commonly used wide-field imaging devices and review conditions seen in ocular oncology clinic that underwent wide- ... Full text Link to item Cite

Circumscribed choroidal hemangioma

Chapter · January 1, 2019 Circumscribed choroidal hemangiomas are benign vascular tumors that can produce retinal exudation and fluid leakage. ... Full text Cite

Combined hamartoma of the retina and retinal pigment epithelium

Chapter · January 1, 2019 Combined hamartomas of the retina and the retinal pigment epithelium (RPE) produce intraretinal lesions with preretinal gliosis, which can be monitored with optical coherence tomography (OCT). ... Full text Cite

Choroidal osteoma

Chapter · January 1, 2019 Choroidal osteomas are bone-containing lesions in the choroid. ... Full text Cite

Retinal capillary hemangioblastoma

Chapter · January 1, 2019 Retinal capillary hemangioblastomas are benign vascular tumors associated with von Hippel Lindau disease and may produce retinal exudation, retinal detachment, and preretinal fibrosis. ... Full text Cite

Choroidal nevus and congenital hypertrophy of the retinal pigment epithelium

Chapter · January 1, 2019 A choroidal nevus is a benign melanocytic proliferation of the choroid with very low risk of progression to choroidal melanoma in children. Optical coherence tomography (OCT) findings can detect the choroidal component and overlying changes to the neurosen ... Full text Cite

Retinoblastoma

Chapter · January 1, 2019 Retinoblastoma is the most common cancer of the eye in children. Optical coherence tomography (OCT) can help define early small tumor formation, relapse of previously treated tumors, detection and monitoring of vitreous seeds, and response to therapy. ... Full text Cite

Diffuse choroidal hemangioma

Chapter · January 1, 2019 Diffuse choroidal hemangioma occurs commonly in the setting of Sturge-Weber syndrome and is associated with dilated choroidal vessels, choroidal thickening, and, in some cases, exudative retinal detachment. ... Full text Cite

Retinal astrocytic hamartoma

Chapter · January 1, 2019 Retinal astrocytic hamartomas (RAHs) are benign tumors of the inner retina associated with the tuberous sclerosis complex. A well-defined, stationary inner retinal tumor involving the nerve fiber layer may be associated with intralesional calcific deposits ... Full text Cite

Real-World Plaque Brachytherapy Clinical Practices among Ocular Oncology Study Consortium Treatment Centers

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

CHOROIDAL TUMOR BIOPSY: A Review of the Current State and a Glance Into Future Techniques.

Journal Article Retina · September 2018 PURPOSE: To review the indications for and the methods of obtaining biopsies in eyes with uveal melanoma. In addition, this review provides recommendations for avoiding biopsy-related complications and discusses the future directions of biopsy techniques f ... Full text Link to item Cite

Conjunctival Dehiscence and Scleral Necrosis following Iodine-125 Plaque Brachytherapy for Uveal Melanoma: A Report of 3 Cases.

Journal Article Ocul Oncol Pathol · September 2018 BACKGROUND/AIMS: Plaque brachytherapy is currently the most common treatment for uveal melanoma and has many known potential complications. Here we present 3 cases of early conjunctival and scleral necrosis following iodine-125 plaque. METHODS: This study ... Full text Link to item Cite

Biopsy of a Choroidal Melanoma Using Transvitreal Pars Plana Vitrectomy.

Journal Article Ophthalmic Surg Lasers Imaging Retina · August 1, 2018 Determining when a previously benign choroidal nevi becomes malignant can be challenging, as traditional biopsy methods are often invasive and can lead to secondary complications such as endophthalmitis and vitreous hemorrhage. Using a transvitreal approac ... Full text Link to item Cite

Spectral-domain optical coherence tomography findings in Coats' disease

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · July 1, 2018 Link to item Cite

Macular Features on Spectral-Domain Optical Coherence Tomography Imaging Associated With Visual Acuity in Coats' Disease.

Journal Article Invest Ophthalmol Vis Sci · June 1, 2018 PURPOSE: To investigate the association between macular features on spectral-domain optical coherence tomography (SD-OCT) and visual acuity (VA) in Coats' disease. METHODS: Thirty-nine eyes (39 patients) with SD-OCT from January 1, 2008 to December 31, 201 ... Full text Link to item Cite

A Case of Progressive Dimming Vision.

Journal Article JAMA Ophthalmol · April 1, 2018 Full text Link to item Cite

MOLECULAR PROGNOSTICS FOR UVEAL MELANOMA.

Journal Article Retina · February 2018 PURPOSE: To review laboratory methods, currently available commercial tests, caveats and clinical tips regarding prognostic analysis of uveal melanoma tissue. METHODS: A review of the literature was performed focused on the genetic abnormalities found in u ... Full text Link to item Cite

Efficacy and Safety of Low-Dose Iodine Plaque Brachytherapy for Juxtapapillary Choroidal Melanoma.

Journal Article Am J Ophthalmol · February 2018 PURPOSE: To evaluate low- vs high-dose plaque brachytherapy for juxtapapillary choroidal melanoma. DESIGN: Retrospective interventional case series. METHODS: Setting: Single institution. STUDY POPULATION: Forty-seven patients with juxtapapillary choroidal ... Full text Link to item Cite

MOLECULAR PROGNOSTICS FOR UVEAL MELANOMA

Journal Article RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES · February 1, 2018 Link to item Cite

Association between Tumor Regression Rate and Gene Expression Profile after Iodine 125 Plaque Radiotherapy for Uveal Melanoma.

Journal Article Ophthalmology · October 2017 PURPOSE: Gene expression profile (GEP) testing segregates uveal melanoma (UM) into 2 main prognostic classes. It is unknown if a greater tumor regression response after iodine 125 (I125) brachytherapy correlates with class 2 GEP status. The purpose of this ... Full text Link to item Cite

Multifocal iris melanoma in a 2-year-old managed with I-125 plaque brachytherapy.

Journal Article J AAPOS · October 2017 We report a 23-month-old patient presenting with multifocal iris melanoma who underwent plaque brachytherapy with full corneal coverage. The lesion demonstrated several high-risk clinical and histopathologic features associated with iris melanoma in adults ... Full text Link to item Cite

Neuro-oculo-cutaneous cavernous hemangiomas: a CCM1 mutation-associated phakomatosis.

Journal Article J AAPOS · October 2017 Evaluation for intracranial lesions in a patient with retinal cavernous hemangiomas is vital for early recognition of this heritable and potentially life-threatening disease. We report a case of a highly penetrant but variably expressed form of cerebral ca ... Full text Link to item Cite

Pediatric conjunctival melanoma arising from a compound nevus.

Journal Article Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · October 2017 We present a rare case of conjunctival melanoma in a 9-year-old girl who presented with a conjunctival lesion of the left eye, growth of which was documented by patient photographs. Examination showed a raised pigmented lesion at the temporal limbus, with  ... Full text Cite

Characterization of Artifacts Associated With Multicolor Confocal Scanning Laser Ophthalmoscopy.

Journal Article Ophthalmic Surg Lasers Imaging Retina · October 1, 2017 BACKGROUND AND OBJECTIVE: To characterize the appearance of three types of artifacts observed on multicolor confocal scanning laser ophthalmoscopy (cSLO). PATIENTS AND METHODS: Retrospective review of 159 eyes of 96 consecutive patients from the Duke Eye C ... Full text Link to item Cite

Comparison of Visual Outcomes in Coats' Disease: A 20-Year Experience.

Journal Article Ophthalmology · September 2017 PURPOSE: To report differences in visual acuities among patients with Coats' disease who sought treatment at a tertiary care university-based practice. DESIGN: Single-center retrospective cohort study. PARTICIPANTS: Patients with Coats' disease diagnosed c ... Full text Link to item Cite

Therapies for Macular Edema Associated with Branch Retinal Vein Occlusion: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · September 2017 PURPOSE: To evaluate the available evidence on the ocular safety and efficacy of current therapeutic alternatives for the management of macular edema (ME) secondary to branch retinal vein occlusion (BRVO). METHODS: Literature searches were last conducted o ... Full text Link to item Cite

Everolimus to treat aggressive retinal astrocytic hamartoma in tuberous sclerosis complex.

Journal Article J AAPOS · August 2017 Retinal astrocytic hamartomas (RAH) are the most frequent ocular manifestation of tuberous sclerosis complex and are usually indolent, requiring only observation. We report an aggressive RAH subtype in a child unresponsive to anti-VEGF and laser therapy. T ... Full text Link to item Cite

Outcomes of 27-Gauge Vitrectomy-Assisted Choroidal and Subretinal Biopsy.

Journal Article Ophthalmic Surg Lasers Imaging Retina · May 1, 2017 BACKGROUND AND OBJECTIVE: To report the initial experience of 27-gauge vitrectomy-assisted choroidal and subretinal biopsy PATIENTS AND METHODS: Retrospective, interventional case series. Eighteen eyes of 18 patients undergoing 27-gauge vitrectomy-assisted ... Full text Link to item Cite

Intraoperative 4-Dimensional Microscope-Integrated Optical Coherence Tomography-Guided 27-Gauge Transvitreal Choroidal Biopsy for Choroidal Melanoma.

Journal Article Retina · April 2017 PURPOSE: We describe two cases of intraoperative 4D microscope–integrated swept source optical coherence tomography (4D MIOCT) guided 27-gauge transvitreal retinochoroidal biopsy for choroidal melanoma. METHODS: Two 68-year-old females with choroidal melan ... Full text Link to item Cite

Ocular Surface Epithelial Atypia Mimicking Squamous Neoplasia in Association With Ulcerative Colitis.

Journal Article Cornea · April 2017 PURPOSE: Inflammatory bowel disease may be associated with extraintestinal manifestations. We report a case of severe reactive epithelial atypia resembling ocular surface squamous neoplasia (OSSN) in a patient with ulcerative colitis (UC). METHODS: Case re ... Full text Link to item Cite

Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.

Journal Article Ophthalmology · March 2017 PURPOSE: To evaluate the available evidence in peer-reviewed publications about the diagnosis and treatment of acute retinal necrosis (ARN). METHODS: Literature searches of the PubMed and Cochrane Library databases were last conducted on July 27, 2016. The ... Full text Link to item Cite

Association of Pediatric Choroidal Neovascular Membranes at the Temporal Edge of Optic Nerve and Retinochoroidal Coloboma.

Journal Article Am J Ophthalmol · February 2017 PURPOSE: To describe the characteristics of pediatric choroidal neovascular membranes (CNVs) associated with retinochoroidal and optic nerve coloboma using optical coherence tomography (OCT) and their response to treatment. DESIGN: Retrospective case serie ... Full text Link to item Cite

Advances in the management of conjunctival melanoma.

Journal Article Surv Ophthalmol · 2017 Malignant melanoma of the conjunctiva is a rare but serious condition. Over the last several years, there have been important advances in the classification, diagnosis, and treatment of this condition. Recent cytogenetic and immunohistochemical studies are ... Full text Link to item Cite

Wide field of view swept-source optical coherence tomography for peripheral retinal disease.

Journal Article Br J Ophthalmol · October 2016 BACKGROUND/AIMS: To assess peripheral retinal lesions and the posterior pole in single widefield optical coherence tomography (OCT) volumes. METHODS: A wide field of view (FOV) swept-source OCT (WFOV SSOCT) system was developed using a commercial swept-sou ... Full text Link to item Cite

Portable Optical Coherence Tomography Detection or Confirmation of Ophthalmoscopically Invisible or Indeterminate Active Retinoblastoma.

Journal Article Ophthalmic Surg Lasers Imaging Retina · October 1, 2016 Portable, hand-held optical coherence tomography (OCT) revealed three clinically relevant yet not ophthalmoscopically detected or confirmed manifestations of retinoblastoma in a single patient with familial bilateral disease. Specifically, OCT showed new r ... Full text Link to item Cite

Impact of Microscope-Integrated OCT on Ophthalmology Resident Performance of Anterior Segment Surgical Maneuvers in Model Eyes.

Journal Article Invest Ophthalmol Vis Sci · July 1, 2016 PURPOSE: The integration of swept-source optical coherence tomography (SS-OCT) into the operating microscope enables real-time, tissue-level three-dimensional (3D) imaging to aid in ophthalmic microsurgery. In this prospective randomized controlled study, ... Full text Link to item Cite

SMALL-GAUGE VALVED VERSUS NONVALVED CANNULA PARS PLANA VITRECTOMY FOR RETINAL DETACHMENT REPAIR.

Journal Article Retina · April 2016 PURPOSE: To compare functional and anatomical outcomes and complication rates between valved versus traditional nonvalved small-gauge cannula vitrectomy for retinal detachment repair. METHODS: Retrospective case series of 163 eyes undergoing small-gauge va ... Full text Link to item Cite

Low-dose brachytherapy strategies to treat uveal melanoma: is less more?

Journal Article Melanoma Manag · March 2016 The Collaborative Ocular Melanoma Study (COMS) has established equivalency of globe salvaging brachytherapy compared with enucleation in terms of survival for medium-sized choroidal melanoma. The radiation dose protocol followed by the COMS was 85 Gray to ... Full text Link to item Cite

A Comparative Study of Rebound Tonometry With Tonopen and Goldmann Applanation Tonometry Following Vitreoretinal Surgery.

Journal Article Am J Ophthalmol · January 2016 PURPOSE: To investigate agreement in intraocular pressure (IOP) measurements among Icare rebound tonometry, Tonopen tonometry, and Goldmann applanation tonometry following vitreoretinal surgery. DESIGN: Reliability analysis of tonometers. METHODS: Fifty-ey ... Full text Link to item Cite

Primary adenocarcinoma of pigmented ciliary epithelium in a phthisical eye.

Journal Article Surv Ophthalmol · 2016 We report a case of adenocarcinoma of the pigmented ciliary epithelium arising in a phthisical eye. A 92-year-old man who initially presented with severe ocular pain had calcification extending from the posterior pole to ciliary body on B-scan ultrasonogra ... Full text Link to item Cite

Scleral Buckling with Chandelier Illumination.

Journal Article J Ophthalmic Vis Res · 2016 Scleral buckling is a highly successful technique for the repair of rhegmatogenous retinal detachment that requires intra-operative examination of the retina and treatment of retinal breaks via indirect ophthalmoscopy. Data suggest that scleral buckling li ... Full text Link to item Cite

Subretinal Hyperreflective Material in the Comparison of Age-Related Macular Degeneration Treatments Trials.

Journal Article Ophthalmology · September 2015 PURPOSE: To evaluate the association of subretinal hyperreflective material (SHRM) with visual acuity (VA), geographic atrophy (GA), and scar in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Prospective cohort study w ... Full text Link to item Cite

En face imaging of retinal pathology using multicolor confocal scanning laser ophthalmoscopy

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Ultra wide-field swept-source optical coherence tomography for peripheral eye disease

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2015 Link to item Cite

Retained Intraocular Perfluoro-n-octane After Valved Cannula Pars Plana Vitrectomy for Retinal Detachment.

Journal Article Ophthalmic Surg Lasers Imaging Retina · April 2015 BACKGROUND AND OBJECTIVE: To investigate cases of retained intraocular perfluoro-n-octane (PFO) after pars plana vitrectomy (PPV) for retinal detachment (RD). PATIENTS AND METHODS: Retrospective, noncomparative case series of six eyes with retained intraoc ... Full text Link to item Cite

Conjunctival melanoma.

Other JAMA Ophthalmol · December 2014 Full text Link to item Cite

Corticosteroids for the Treatment of Diabetic Macular Edema

Journal Article Theoretical Chemistry Accounts · December 1, 2014 Diabetic macular edema (DME) is a leading cause of vision loss throughout the world. Three different corticosteroids have been used in the treatment of diabetic macular edema: triamcinolone acetonide, dexamethasone, and fluocinolone acetonide. Intravitreal ... Full text Cite

Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration.

Journal Article Retina · September 2014 PURPOSE: To compare 25-hydroxyvitamin D (25OHD) levels in patients with neovascular age-related macular degeneration (NVAMD) with patients with nonneovascular age-related macular degeneration and control patients. METHODS: Medical records of all patients d ... Full text Link to item Cite

Optimizing Laser Parameters for Pump-Probe Microscopy of Conjunctival Melanocytic Lesions

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Spectral Domain Optical Coherence Tomography Imaging of Ocular Surface Lesions

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · April 1, 2014 Link to item Cite

Characterization of the choroid-scleral junction and suprachoroidal layer in healthy individuals on enhanced-depth imaging optical coherence tomography.

Journal Article JAMA Ophthalmol · February 2014 IMPORTANCE: Accurate measurements of choroidal thickness (CT) using enhanced-depth imaging optical coherence tomography (EDI-OCT) require a well-defined choroid-scleral junction (CSJ), which may appear in some eyes as a hyporeflective band corresponding to ... Full text Link to item Cite

Reduced fluorescein angiography and fundus photography use in the management of neovascular macular degeneration and macular edema during the past decade.

Journal Article Invest Ophthalmol Vis Sci · January 29, 2014 PURPOSE: We assessed recent trends in the use of diagnostic testing for neovascular age-related macular degeneration (NVAMD) and macular edema (ME). METHODS: Claims data from a managed-care network were analyzed on patients with NVAMD (n = 22,954) or ME (n ... Full text Link to item Cite

Choroidal metastatasis from a neuroendocrine tumor masquerading as choroidal melanoma.

Journal Article Ophthalmic Surg Lasers Imaging Retina · 2014 A mushroom-shaped choroidal mass is classically suggestive of melanoma, due to the ability of these tumors to erupt through Bruch's membrane. In contrast, choroidal metastases rarely adopt this growth pattern. The authors present an unusual case of a patie ... Full text Link to item Cite

Retinal metastatic tumors

Chapter · January 1, 2014 Intraocular metastasis is the most common intraocular tumor. The most common primary tumor site is the lung in men and breast in women [1]. In the majority of cases, intraocular metastasis is limited to choroid. Other ocular structures, like the vitreous, ... Full text Cite

Imaging microscopic pigment chemistry in conjunctival melanocytic lesions using pump-probe laser microscopy.

Journal Article Invest Ophthalmol Vis Sci · October 21, 2013 PURPOSE: To report the application of a novel imaging technique, pump-probe microscopy, to analyze patterns of pigment chemistry of conjunctival melanocytic lesion biopsies. METHODS: Histopathologic specimens of eight previously excised conjunctival melano ... Full text Link to item Cite

Imaging pigment chemistry in melanocytic conjunctival lesions with pump-probe microscopy

Chapter · June 7, 2013 We extend nonlinear pump-probe microscopy, recently demonstrated to image the microscopic distribution of eumelanin and pheomelanin in unstained skin biopsy sections, to the case of melanocytic conjunctival lesions. The microscopic distribution of pigmenta ... Full text Cite

Pump-Probe Laser Imaging of Pigment in Conjunctival Melanocytic Lesions

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · June 1, 2013 Link to item Cite

Diagnostic yield of vitreous biopsy in presumed sarcoidosis-related posterior segment inflammation.

Journal Article Graefes Arch Clin Exp Ophthalmol · September 2012 PURPOSE: Diagnostic vitrectomy is frequently used to help establish a diagnosis in challenging uveitis cases. The usefulness of this procedure in patients with suspected sarcoidosis with posterior segment involvement, in whom a diagnosis cannot be determin ... Full text Link to item Cite

Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma.

Journal Article Ophthalmology · August 2012 PURPOSE: This study evaluates the prognostic performance of a 15 gene expression profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic subgroups: class 1 (low metastatic risk) and class 2 (high metastatic risk). DESIGN: Prospec ... Full text Link to item Cite

Image inversion spectral-domain optical coherence tomography optimizes choroidal thickness and detail through improved contrast.

Journal Article Invest Ophthalmol Vis Sci · April 6, 2012 PURPOSE: This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical ... Full text Link to item Cite

Retinal manifestations of oncologic and hematologic conditions.

Journal Article Int Ophthalmol Clin · 2012 Featured Publication Full text Link to item Cite

Unanticipated vision loss after pars plana vitrectomy.

Journal Article Surv Ophthalmol · 2012 Although advances in vitreoretinal surgical techniques and technology have helped to minimize the risks associated with surgical manipulation of the retina, retinal pigment epithelium, and optic nerve, unanticipated or unexplained visual loss still occurs. ... Full text Link to item Cite

Medicare costs for neovascular age-related macular degeneration, 1994-2007.

Journal Article Am J Ophthalmol · December 2011 Featured Publication PURPOSE: To assess changes in Medicare payments for neovascular age-related macular degeneration (AMD) since introduction of anti-vascular endothelial growth factor (VEGF) therapies. DESIGN: Retrospective, longitudinal cohort study. METHODS: Using the Medi ... Full text Link to item Cite

Ocular complications after anti-vascular endothelial growth factor therapy in Medicare patients with age-related macular degeneration.

Journal Article Am J Ophthalmol · August 2011 Featured Publication PURPOSE: To determine longitudinal rates of ocular complications after anti-vascular endothelial growth factor (VEGF) treatment for neovascular age-related macular degeneration (AMD) in a nationally representative longitudinal sample. DESIGN: Retrospective ... Full text Link to item Cite

Optimizing diagnosis and management of nocardia keratitis, scleritis, and endophthalmitis: 11-year microbial and clinical overview.

Journal Article Ophthalmology · June 2011 Featured Publication OBJECTIVE: To identify clinical factors and microbiological assays that facilitate a rapid diagnosis of Nocardia keratitis, scleritis, and endophthalmitis, and to determine optimal medical and surgical management strategies. DESIGN: Retrospective, consecut ... Full text Link to item Cite

Retinal pigment epithelial detachments in age-related macular degeneration: classification and therapeutic options.

Journal Article Semin Ophthalmol · May 2011 Featured Publication Retinal pigment epithelial detachment (PED) is an important predictor of vision loss in patients with age-related macular degeneration (AMD). Here we review the historical PEDs subtypes, include recent insights into PED pathogenesis provided by modern imag ... Full text Link to item Cite

Reply

Other American Journal of Ophthalmology · April 1, 2011 Full text Cite

Bacterial contamination of needles used for intravitreal injections: a prospective, multicenter study.

Journal Article Ocul Immunol Inflamm · February 2011 Featured Publication PURPOSE: To determine the incidence of bacterial contamination of needles used for intravitreal injections. METHODS: Patients undergoing intravitreal injections were enrolled prospectively. No pre-injection antibiotics were administered. Following povidone ... Full text Link to item Cite

Evaluation of contrast agents for enhanced visualization in optical coherence tomography.

Journal Article Invest Ophthalmol Vis Sci · December 2010 Featured Publication PURPOSE: To identify and evaluate the use of contrast agents in optical coherence tomography (OCT) for ophthalmic applications. METHODS: Three agents-prednisolone acetate (PA), triamcinolone acetonide (TA), and lipid-based artificial tears (LBAT)-were test ... Full text Link to item Cite

One-year outcomes after retinal detachment surgery among medicare beneficiaries.

Journal Article Am J Ophthalmol · September 2010 Featured Publication PURPOSE: To determine longitudinal rates of second retinal detachment operation and postoperative adverse outcomes after retinal detachment surgery in a nationally representative sample of older Americans. DESIGN: Retrospective, longitudinal cohort analysi ... Full text Link to item Cite

Postoperative cilioretinal artery occlusion in Sturge Weber-associated glaucoma.

Journal Article J AAPOS · August 2010 Featured Publication Surgical management of Sturge Weber-associated glaucoma is challenging. Choroidal effusion and expulsive choroidal hemorrhage are commonly cited potential risks. We report a case of a cilioretinal artery occlusion associated with glaucoma drainage device s ... Full text Link to item Cite

Transpositional Autokeratoplasty in a Patient with Unilateral Choroidal Melanoma and Contralateral Exposure Keratopathy.

Journal Article Ophthalmic Surg Lasers Imaging · March 9, 2010 Featured Publication Penetrating keratoplasty was required to improve corneal clarity in the left eye, which had suffered chronic exposure keratopathy following a cerebellopontine angle tumor with facial nerve involvement. The right eye had a large choroidal melanoma, which ha ... Full text Link to item Cite

Clinical and ocular pathological findings in Von Hippel-Lindau disease

Journal Article Clinical and Surgical Ophthalmology · June 1, 2009 Objectives: To report a patient with Von Hippel-Lindau (VHL) disease demonstrating classic ocular findings. Design'. Retrospective case report. Methods: Clinical and pathological findings. Main Outcome Measures: Clinical course and pathological findings. R ... Cite

Identification of patients with diabetic macular edema from claims data: a validation study.

Journal Article Arch Ophthalmol · July 2008 Featured Publication OBJECTIVE: To assess the validity of an algorithm for identifying patients with diabetic macular edema (DME) using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis codes in administrative billing data fro ... Full text Link to item Cite

Unusual case of diffuse choroidal melanoma masquerading as atypical central serous chorioretinopathy.

Journal Article Retin Cases Brief Rep · 2008 PURPOSE: To describe an unusual case of diffuse circumpapillary choroidal melanoma masquerading as atypical central serous chorioretinopathy, and to describe fluorescein angiographic and optical coherence tomography characteristics of this diffuse choroida ... Full text Link to item Cite

Choroidal metastasis of follicular thyroid adenocarcinoma diagnosed by 25-gauge transretinal biopsy.

Journal Article Ann Ophthalmol (Skokie) · 2008 Featured Publication We report a case of a patient with previously treated follicular thyroid carcinoma who presented with a symptomatic amelanotic choroidal mass with low internal reflectivity and a metastatic lytic skull lesion. A 25-gauge vitrector was used to perform trans ... Link to item Cite

Malignant transformation of iris melanocytoma to iris ring melanoma.

Other Br J Ophthalmol · November 2007 Featured Publication Full text Link to item Cite

Efficacy of low-release-rate fluocinolone acetonide intravitreal implants to treat experimental uveitis.

Journal Article Arch Ophthalmol · July 2006 Featured Publication OBJECTIVE: To determine the efficacy of 0.5-mg and 0.1-mg sustained-release fluocinolone acetonide intravitreal implants to inhibit ocular inflammation in a rabbit model of severe uveitis. METHODS: The in vitro pharmacokinetic profile of both the 0.5-mg an ... Full text Link to item Cite

Central retinal vein occlusion in patients treated with long-term warfarin sodium (Coumadin) for anticoagulation.

Journal Article Retina · March 2006 Featured Publication PURPOSE: To describe the clinical features of persons who developed central retinal vein occlusion (CVO) while being treated with Coumadin for chronic anticoagulation. METHODS: In a retrospective, comparative, noninterventional case series of patients diag ... Full text Link to item Cite

Central Retinal Vein Occlusion

Chapter · September 27, 2005 Full text Cite

Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy.

Journal Article Arch Ophthalmol · July 2005 Featured Publication OBJECTIVE: To assess the prevalence of recurrence of macular geographic atrophy (GA) of the retinal pigment epithelium (RPE) after macular translocation with 360 degrees retinectomy (MT360) in one institution. METHODS: A retrospective review of all cases o ... Full text Link to item Cite

Impact of fluorescein angiographic characteristics of macular lesions on outcomes after macular translocation 360 degree surgery in eyes with age-related macular degeneration.

Journal Article Retina · 2005 Featured Publication PURPOSE: To evaluate the relationship between preoperative lesion size and composition and visual outcomes at 1 year after macular translocation surgery with 360 degree peripheral retinectomy (MT360) for neovascular age-related macular degeneration (AMD). ... Full text Link to item Cite

Relaxing retinotomy in proliferative vitreoretinopathy surgery: Long term results

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · January 1, 2005 Link to item Cite

Change in visual function after macular translocation with 360 degrees retinectomy for neovascular age-related macular degeneration.

Journal Article Ophthalmology · September 2004 Featured Publication OBJECTIVE: To measure the change in vision and visual outcomes at 12 months after macular translocation with 360 degrees retinectomy (MT360) and silicone oil tamponade in patients with bilateral vision loss resulting from subfoveal choroidal neovascular me ... Full text Link to item Cite

Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancy.

Journal Article Ophthalmology · June 2002 Featured Publication PURPOSE: To determine the yield of diagnostic pars plana vitrectomy in eyes with suspected posterior segment inflammation or malignancy when clinical examination and systemic laboratory testing did not yield a specific diagnosis. DESIGN: Non-comparative in ... Full text Link to item Cite

Central retinal vein occlusion in patients on chronic Coumadin (R) anticoagulation

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · May 1, 2002 Link to item Cite

Diagnostic yield of vitrectomy in eyes with suspected posterior segment infection or malignancy.

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 2000 Link to item Cite

Frequency of vitreoretinal surgery in uveitis patients

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1999 Link to item Cite

Clinicomicrobiological review of Nocardia keratitis.

Journal Article Cornea · January 1998 Featured Publication PURPOSE: To present the clinical profile, laboratory results, and outcome of treatment in 16 patients with Nocardia keratitis. METHODS: A retrospective review of 16 culture-proven cases of Nocardia keratitis was done. Clinical and microbiologic data were a ... Full text Link to item Cite

Juvenile xanthogranuloma of the lacrimal sac fossa.

Journal Article Am J Ophthalmol · March 1997 Featured Publication PURPOSE: Masses involving the medial canthus and lacrimal sac fossa include dacryocystoceles and, less commonly, mucoceles, hemangiomas, diverticula, and lacrimal sac neoplasms. To our knowledge, juvenile xanthogranuloma presenting as a lacrimal sac fossa ... Full text Link to item Cite

Subjective and objective outcomes of strabismus surgery in children.

Journal Article J Pediatr Ophthalmol Strabismus · 1996 Featured Publication BACKGROUND: The negative psychosocial impact of strabismus in adults has been well documented. Despite the increasingly recognized importance of outcomes research, parents' satisfaction with strabismus treatment in childhood and their assessment of its fun ... Full text Link to item Cite

THE MINIMUM INHIBITORY AND BACTERICIDAL CONCENTRATIONS OF ANTIBIOTICS FOR VITREOUS ISOLATES

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1995 Link to item Cite

MULTICOLOR IMAGING OF INNER RETINAL ALTERATIONS AFTER INTERNAL LIMITING MEMBRANE PEELING.

Journal Article Retin Cases Brief Rep PURPOSE: To characterize the appearance of inner retinal alterations after internal limiting membrane (ILM) peeling using multicolor confocal scanning laser ophthalmoscopy (cSLO). METHODS: Retrospective review of two eyes that underwent pars plana vitrecto ... Full text Link to item Cite