Scholars@Duke
Deborah Marie Muoio

Deborah Marie Muoio

George Barth Geller Distinguished Professor of Cardiovascular Disease
Medicine, Endocrinology, Metabolism, and Nutrition
muoio@duke.edu
Duke Box 104775, Durham, NC 27710
300 North Duke Street, Durham, NC 27701

Scholarly Works - Conferences

Abstract Wed007: Postnatal loss of the nuclear receptor PPARĪ± in cardiomyocytes promotes glycolytic remodeling and cardiomyocyte dedifferentiation via Fbp2 downregulation

Conference Circulation Research · August 2025 Cardiomyocytes (CMs) undergo metabolic and contractile reprogramming during cardiac stress and injury. This reprogramming response includes a fuel metabolic shift to a more fetal-like or immature state with downregulation in fatty acid ... Full text Cite

212-OR: Hepatic Overexpression of ACSS3 Alters Glucose Control and Fatty Acid Metabolism in Lean Mice

Conference Diabetes · June 20, 2025 Introduction and Objective: Short chain fatty acids (SCFAs) are associated with adverse metabolic outcomes; however, little is known about their link to metabolic disease. Emerging evidence suggests that in addition to acting as signaling molecules ... Full text Cite

Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans.

Conference JCI Insight · January 10, 2023 BACKGROUNDAt the onset of exercise, the speed at which phosphocreatine (PCr) decreases toward a new steady state (PCr on-kinetics) reflects the readiness to activate mitochondrial ATP synthesis, which is secondary to Acetyl-CoA availability in skeletal mus ... Full text Link to item Cite

Abstract P284: The Chemotherapeutic Agent Docetaxel Disrupts Mitochondrial Energetics in 3D Human Bioengineered Myobundles

Conference Circulation · March 5, 2019 Taxanes (i.e. docetaxel, (TAX)) comprise the first line-treatment for breast cancer (BC), mostly in combination with anthracyclines like doxorubicin (DOX). The efficacy of these drugs as antineoplastic agents has helped to boost 10-yea ... Full text Cite

Increasing fatty acid oxidation in the failing heart does not improve cardiac function

Conference Journal of Molecular and Cellular Cardiology · November 2018 Full text Cite

Abstract 3004: Contextual RNAi screen identifies ACLY and ACC1 as mediators of hypoxia-induced apoptosis through metabolic and transcriptional mechanisms

Conference Cancer Research · August 1, 2015 AbstractTo become established as a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME) stresses, such as hypoxia or lactic acidosis. While many stress-signaling mec ... Full text Cite

Abstract PR09: A genome-wide RNAi screen reveals a protective role of decreased lipogenesis under hypoxia

Conference Cancer Research · January 1, 2015 AbstractAs solid tumors form, a number of physiological changes occur within the tumor, including low oxygen levels (hypoxia) and an accumulation of lactic acid with concomitant lowered pH levels (lactic aci ... Full text Cite

Effect of sex steroids on beta-endorphin levels at rest and during submaximal treadmill exercise in anovulatory and ovulatory runners.

Conference Fertil Steril · June 1999 OBJECTIVE: To examine the interaction between circulating beta-endorphin levels and sex steroids during sustained submaximal exercise in runners who are either anovulatory and oligomenorrheic (AO) or ovulatory and eumenorrheic (EO). DESIGN: Controlled clin ... Full text Link to item Cite

Peripheral metabolic actions of leptin.

Conference Proc Nutr Soc · August 1998 Full text Link to item Cite