Matthew Wolf Foster

Journal article JCI Insight · January 16, 2020 Featured Publication The T helper 2 (Th2) inflammatory cytokine interleukin-13 (IL-13) has been associated with both obstructive and fibrotic lung diseases; however, its specific effect on the epithelial stem cells in the gas exchange compartment of the lung (alveolar space) h ... Full text Link to item Cite

Targeted Proteomics of Human Metapneumovirus in Clinical Samples and Viral Cultures.

Journal article Anal Chem · October 20, 2015 Featured Publication The rapid, sensitive, and specific identification of infectious pathogens from clinical isolates is a critical need in the hospital setting. Mass spectrometry (MS) has been widely adopted for identification of bacterial pathogens, although polymerase chain ... Full text Link to item Cite

Quantitative proteomics of bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis.

Journal article J Proteome Res · February 6, 2015 Featured Publication The proteomic analysis of bronchoalveolar lavage fluid (BALF) can give insight into pulmonary disease pathology and response to therapy. Here, we describe the first gel-free quantitative analysis of BALF in idiopathic pulmonary fibrosis (IPF), a chronic an ... Full text Link to item Cite

Identification and Quantitation of Coding Variants and Isoforms of Pulmonary Surfactant Protein A.

Journal article J Proteome Res · August 1, 2014 Featured Publication Pulmonary surfactant protein A (SP-A), a heterooligomer of SP-A1 and SP-A2, is an important regulator of innate immunity of the lung. Nonsynonymous single nucleotide variants of SP-A have been linked to respiratory diseases, but the expressed repertoire of ... Full text Link to item Cite

Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure.

Journal article J Proteome Res · May 3, 2013 Featured Publication The analysis of airway fluid, as sampled by bronchoalveolar lavage (BAL), provides a minimally invasive route to interrogate lung biology in health and disease. Here, we used immunodepletion, coupled with gel- and label-free LC-MS/MS, for quantitation of t ... Full text Link to item Cite

Methodologies for the characterization, identification and quantification of S-nitrosylated proteins.

Journal article Biochim Biophys Acta · June 2012 Featured Publication BACKGROUND: Protein S-nitrosylation plays a central role in signal transduction by nitric oxide (NO), and aberrant S-nitrosylation of specific proteins is increasingly implicated in disease. SCOPE OF REVIEW: Here, methodologies for the characterization, id ... Full text Link to item Cite

S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction.

Journal article Am J Physiol Lung Cell Mol Physiol · November 2011 Featured Publication S-nitrosoglutathione (GSNO) is an endogenous bronchodilator present in micromolar concentrations in airway lining fluid. Airway GSNO levels decrease in severe respiratory failure and asthma, which is attributable to increased metabolism by GSNO reductase ( ... Full text Link to item Cite

Thioredoxin-interacting protein (Txnip) is a feedback regulator of S-nitrosylation.

Journal article J Biol Chem · December 25, 2009 Featured Publication Nitric oxide exerts a plethora of biological effects via protein S-nitrosylation, a redox-based reaction that converts a protein Cys thiol to a S-nitrosothiol. However, although the regulation of protein S-nitrosylation has been the subject of extensive st ... Full text Link to item Cite

A protein microarray-based analysis of S-nitrosylation.

Journal article Proc Natl Acad Sci U S A · November 10, 2009 Featured Publication The ubiquitous cellular influence of nitric oxide (NO) is exerted substantially through protein S-nitrosylation. Whereas NO is highly promiscuous, physiological S-nitrosylation is typically restricted to one or very few Cys residue(s) in target proteins. T ... Full text Link to item Cite

Protein S-nitrosylation in health and disease: a current perspective.

Journal article Trends Mol Med · September 2009 Featured Publication Protein S-nitrosylation constitutes a large part of the ubiquitous influence of nitric oxide on cellular signal transduction and accumulating evidence indicates important roles for S-nitrosylation both in normal physiology and in a broad spectrum of human ... Full text Link to item Cite

A genetic analysis of nitrosative stress.

Journal article Biochemistry · February 3, 2009 Featured Publication Nitrosative stress is induced by pathophysiological levels of nitric oxide (NO) and S-nitrosothiols (e.g., S-nitrosoglutathione, GSNO) and arises, at least in significant part, from the nitrosylation of critical protein Cys thiols (S-nitrosylation) and met ... Full text Link to item Cite

Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress.

Journal article J Biol Chem · May 11, 2007 Featured Publication Protein S-nitrosylation has emerged as a principal mechanism by which nitric oxide exerts biological effects. Among methods for studying protein S-nitrosylation, the biotin switch technique (BST) has rapidly gained popularity because of the ease with which ... Full text Link to item Cite

Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.

Journal article Cell · May 4, 2007 Featured Publication beta-adrenergic receptors (beta-ARs), prototypic G-protein-coupled receptors (GPCRs), play a critical role in regulating numerous physiological processes. The GPCR kinases (GRKs) curtail G-protein signaling and target receptors for internalization. Nitric ... Full text Link to item Cite

S-nitrosylation TRiPs a calcium switch.

Journal article Nat Chem Biol · November 2006 Featured Publication Full text Link to item Cite

An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.

Journal article Proc Natl Acad Sci U S A · August 23, 2005 Featured Publication The identity of the cellular mechanisms through which nitroglycerin (glyceryl trinitrate, GTN) elicits nitric oxide (NO)-based signaling to dilate blood vessels remains one of the longest standing foci of investigation and sources of controversy in cardiov ... Full text Link to item Cite

Role of circulating S-nitrosothiols in control of blood pressure.

Journal article Hypertension · January 2005 Featured Publication Full text Link to item Cite

New insights into protein S-nitrosylation. Mitochondria as a model system.

Journal article J Biol Chem · June 11, 2004 Featured Publication The biological effects of nitric oxide (NO) are in significant part mediated through S-nitrosylation of cysteine thiol. Work on model thiol substrates has raised the idea that molecular oxygen (O(2)) is required for S-nitrosylation by NO; however, the rele ... Full text Link to item Cite

S-nitrosylation in health and disease.

Journal article Trends Mol Med · April 2003 Featured Publication S-nitrosylation is a ubiquitous redox-related modification of cysteine thiol by nitric oxide (NO), which transduces NO bioactivity. Accumulating evidence suggests that the products of S-nitrosylation, S-nitrosothiols (SNOs), play key roles in human health ... Full text Link to item Cite

Elucidation of a [4Fe-4S] cluster degradation pathway: rapid kinetic studies of the degradation of Chromatium vinosum HiPIP.

Journal article J Biol Inorg Chem · March 2001 Featured Publication Irreversible disassembly of the 4Fe-4S cluster in Chromatium vinosum high-potential iron protein (HiPIP) has been investigated in the presence of a low concentration of guanidinium hydrochloride. From the dependence of degradation rate on [H+], it is deduc ... Full text Link to item Cite