Scholars@Duke
Nada Kais El Husseini

Nada Kais El Husseini

Associate Professor of Neurology
Neurology, Stroke and Vascular Neurology
nada.elhusseini@duke.edu
Box 31217 Med Ctr, Durham, NC 27710
Dept of Neurology, Durham, NC 27710

Scholarly Works

Stroke Risk After Bioprosthetic Aortic Valve Replacement in Aortic Stenosis: Systematic Review and Meta-Analysis.

Journal article Stroke · June 2026 BACKGROUND: Stroke is a possible complication after bioprosthetic aortic valve replacement (AVR) for severe aortic stenosis (AS), impacting morbidity and mortality. Accurate estimates of the proportion of individuals who experience stroke within and beyond ... Full text Link to item Cite

Social and Environmental Determinants of Stroke Functional Outcome and Strategies to Reduce Inequities: A Scientific Statement From the American Heart Association.

Journal article Stroke · June 2026 Stroke is a leading cause of death and disability worldwide, and the recovery process is significantly influenced by a multitude of factors beyond immediate medical treatment. Social and environmental determinants of health-conditions in which people are b ... Full text Link to item Cite

Improving Access to Primordial and Primary Stroke Prevention: Global Considerations.

Journal article J Am Heart Assoc · August 19, 2025 Stroke is the second-leading cause of death and the third-leading cause of disability worldwide. Low- and middle-income countries continue to experience an increase in stroke incidence despite scientific advances to prevent strokes. In this topical review, ... Full text Link to item Cite

Frequency, Risk Factors, and Outcomes of Strokes in Patients With Primary Glioma After Cranial Radiation Therapy.

Journal article Neurology · August 12, 2025 BACKGROUND AND OBJECTIVES: Radiation therapy is the mainstay of therapy for patients with glioma. While this treatment modality can improve survival, treatment-related complications may include radiation-induced vasculopathy and increased risk of stroke. W ... Full text Link to item Cite

MRI Predictors of Cognitive Function After Lacunar Infarction.

Journal article Stroke · July 2025 BACKGROUND: Poststroke cognitive impairment is associated with disability and decreased quality of life. We assessed whether individual or collective magnetic resonance imaging (MRI) biomarkers can aid in predicting cognitive impairment after lacunar infar ... Full text Link to item Cite

2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association.

Journal article Stroke · December 2024 AIM: The "2024 Guideline for the Primary Prevention of Stroke" replaces the 2014 "Guidelines for the Primary Prevention of Stroke." This updated guideline is intended to be a resource for clinicians to use to guide various prevention strategies for individ ... Full text Link to item Cite

Genetic Variation and Stroke Recovery: The STRONG Study.

Journal article Stroke · August 2024 BACKGROUND: Genetic association studies can reveal biology and treatment targets but have received limited attention for stroke recovery. STRONG (Stroke, Stress, Rehabilitation, and Genetics) was a prospective, longitudinal (1-year), genetic study in adult ... Full text Link to item Cite

Prevention of Ischemic Stroke

Book section · June 22, 2024 This book is a unique, comprehensive board review dedicated solely to preventive cardiology. This volume is a companion work to the ASPC Manual of Preventive Cardiology. ... Cite

Retinal vessel caliber and cognitive performance: the multi-ethnic study of atherosclerosis (MESA).

Journal article Sci Rep · February 19, 2024 Retinal vessel calibers share anatomic and physiologic characteristics with the cerebral vasculature and can be visualized noninvasively. In light of the known microvascular contributions to brain health and cognitive function, we aimed to determine if, in ... Full text Link to item Cite

Strategies to Reduce Racial and Ethnic Inequities in Stroke Preparedness, Care, Recovery, and Risk Factor Control: A Scientific Statement From the American Heart Association.

Journal article Stroke · July 2023 Stroke is a disease of disparities, with tremendous racial and ethnic inequities in incidence, prevalence, treatment, and outcomes. The accumulating literature on the relationship between stroke and social determinants of health (ie, the structural conditi ... Full text Link to item Cite

Cognitive Impairment After Ischemic and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association/American Stroke Association.

Journal article Stroke · June 2023 PURPOSE: Cognitive impairment is a common consequence of stroke and has direct implications for poststroke functioning and quality of life, including the ability to maintain a job, live independently, sustain interpersonal relationships, and drive a vehicl ... Full text Link to item Cite

Rehabilitation Therapy Doses Are Low After Stroke and Predicted by Clinical Factors.

Journal article Stroke · March 2023 BACKGROUND: Stroke is a leading cause of long-term disability. Greater rehabilitation therapy after stroke is known to improve functional outcomes. This study examined therapy doses during the first year of stroke recovery and identified factors that predi ... Full text Link to item Cite

Abstract 139: Depression Following Small Vessel Stroke Is Common And More Prevalent In Women

Conference Stroke · February 2023 Background: Post-stroke depression (PSD) affects about one third of stroke survivors and is associated with poorer quality of life. Little is known about the prevalence and independent risk factors fo ... Full text Cite

Abstract WP158: Impact Of Atrial Fibrillation On Clinical Outcomes After Endovascular Thrombectomy: A Post-Hoc Analysis Of The Defuse-3 Trial

Conference Stroke · February 2023 Introduction: Previous studies have failed to show an interaction between known atrial fibrillation (AF) and treatment effect of endovascular thrombectomy (EVT) performed within 6 hours of time last k ... Full text Cite

The hypereosinophilic syndrome - an unusual cause of myocarditis and cardioembolic strokes.

Journal article Am J Med Sci · November 2022 Hypereosinophilic syndrome is a rare disorder characterized by excessive peripheral eosinophilia and eosinophil associated end-organ damage. Clinical presentations are heterogenous and can involve skin, pulmonary, cardiac and neurologic dysfunction. Eosino ... Full text Link to item Cite

Association of in-hospital depression and anxiety symptoms following stroke with 3 months- depression, anxiety and functional outcome.

Journal article J Clin Neurosci · April 2022 BACKGROUND: Post-stroke depression and anxiety are common and are associated with worse post-stroke outcomes. Even though checking for depression during stroke hospitalization has become a common practice, the prognostic value of a positive in-hospital dep ... Full text Link to item Cite

Abstract TP179: Candidate Genes For Small Vessel Ischemic Stroke: A Gwas Pilot Study

Conference Stroke · February 2022 Background: The genetic basis of small vessel stroke (SVS) is poorly understood. Few genetic loci have been identified that may provide insights into SVS pathogenesis. We sought to identify genetic as ... Full text Cite

Effects of Fragmentation and the Case for Greater Cohesion in Neurologic Care Delivery.

Journal article Neurology · January 24, 2022 GOALS: To define fragmentation in neurologic care delivery, explain the positive and negative drivers in neurologic practice that contribute to fragmentation, illustrate situations that increase fragmentation risk, emphasize the costs and impact on both pa ... Full text Link to item Cite

Alternative Payment Models and Associations With Stroke Outcomes, Spending, and Service Utilization: A Systematic Review.

Journal article Stroke · January 2022 Stroke contributes an estimated $28 billion to US health care costs annually, and alternative payment models aim to improve outcomes and lower spending over fee-for-service by aligning economic incentives with high value care. This systematic review evalua ... Full text Link to item Cite

Psychiatric sequelae of stroke affecting the non-dominant cerebral hemisphere.

Journal article J Neurol Sci · November 15, 2021 There are a plethora of cognitive sequelae in addition to neglect and extinction that arise with unilateral right hemispheric stroke (RHS). Cognitive deficits following non-dominant (right) hemisphere stroke are common with unilateral neglect and extinctio ... Full text Link to item Cite

Abstract P180: Protocolized Selection for Telestroke Activation in The Extended Window for Thrombectomy

Conference Stroke · March 2021 Background: The advent of biomarker-driven identification of candidates for acute therapies in the 4.5-24-hour time window has resulted in an increase in the number of telestroke consults with low yie ... Full text Cite

Abstract P67: Role of Genetic Variants in Predicting Cognitive Outcomes Following Small Vessel Ischemic Stroke

Conference Stroke · March 2021 Background: About 20% of patients with small vessel ischemic stroke (SVS) have cognitive impairment; however, the role of genetic factors in predicting cognitive outcomes following SVS has not been fu ... Full text Cite

Accelerated Mineralization as a Mimic of Hemorrhagic Conversion

Journal article Neurology Clinical Practice · February 1, 2021 A 65-year old man was admitted to the neurocritical care unit for possible hemorrhagic transformation of a recent left middle cerebral artery (MCA) stroke. His medical history was notable for atrial fibrillation, end-stage renal disease (ESRD) on hemodialy ... Full text Cite

Prevention of Ischemic Stroke

Book section · 2021 The purpose of this chapter is to provide the latest evidence-based practice guidelines on the primary prevention of ischemic stroke. The guidelines are adapted from major professional societies, including the American College of Cardiology (ACC) and the A ... Full text Cite

Vascular Cellular Adhesion Molecule-1 (VCAM-1) and Memory Impairment in African-Americans after Small Vessel-Type Stroke.

Journal article J Stroke Cerebrovasc Dis · April 2020 BACKGROUND: African-Americans (AA) are 3 times more likely to have small-vessel-type ischemic strokes (SVS) than Whites. Small vessel strokes are associated with cognitive impairment, a relationship incompletely explained by white matter hyperintensity (WM ... Full text Link to item Cite

Association of Kidney Function With 30-Day and 1-Year Poststroke Mortality and Hospital Readmission.

Journal article Stroke · December 2018 Background and Purpose- Kidney dysfunction is common among patients hospitalized for ischemic stroke. Understanding the association of kidney disease with poststroke outcomes is important to properly adjust for case mix in outcome studies, payment models a ... Full text Link to item Cite

Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage.

Journal article J Stroke Cerebrovasc Dis · January 2018 BACKGROUND AND PURPOSE: Genes associated with the inflammatory response and cytostructural integrity may influence recovery following a brain injury. To examine this in the setting of spontaneous intracerebral hemorrhage (ICH), selected single nucleotide p ... Full text Link to item Cite

Depression Status Is Associated with Functional Decline Over 1-Year Following Acute Stroke.

Journal article J Stroke Cerebrovasc Dis · July 2017 BACKGROUND: We investigated the independent association of depression status at 3 and 12 months after stroke and functional decline. METHODS: Data were obtained as part of the multicenter Adherence eValuation After Ischemic stroke Longitudinal (AVAIL) regi ... Full text Link to item Cite

Poststroke Depression: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association.

Journal article Stroke · February 2017 Poststroke depression (PSD) is common, affecting approximately one third of stroke survivors at any one time after stroke. Individuals with PSD are at a higher risk for suboptimal recovery, recurrent vascular events, poor quality of life, and mortality. Al ... Full text Link to item Cite

Renal Dysfunction Is Associated With Poststroke Discharge Disposition and In-Hospital Mortality: Findings From Get With The Guidelines-Stroke.

Journal article Stroke · February 2017 BACKGROUND AND PURPOSE: Kidney disease is a frequent comorbidity in patients presenting with acute ischemic stroke. We evaluated whether the estimated glomerular filtration rate (eGFR) on admission is associated with poststroke in-hospital mortality or dis ... Full text Link to item Cite

Treating In-Hospital Stroke.

Journal article JAMA Neurol · December 2015 Full text Link to item Cite

Comparison of Acoustic Radiation Force Impulse Imaging Derived Carotid Plaque Stiffness With Spatially Registered MRI Determined Composition.

Journal article IEEE Trans Med Imaging · November 2015 Measurements of plaque stiffness may provide important prognostic and diagnostic information to help clinicians distinguish vulnerable plaques containing soft lipid pools from more stable, stiffer plaques. In this preliminary study, we compare in vivo ultr ... Full text Link to item Cite

Chronic kidney disease and stroke.

Journal article Adv Chronic Kidney Dis · November 2014 Chronic kidney disease (CKD) is associated with an increased risk of both ischemic and hemorrhagic stroke. In addition to shared risk factors, this higher cerebrovascular risk is mediated by several CKD-associated mechanisms including platelet dysfunction, ... Full text Link to item Cite

The role of neuroendocrine pathways in prognosis after stroke.

Journal article Expert Rev Neurother · February 2014 A number of neuroendocrine changes have been described after stroke, which may serve adaptive or deleterious functions. The neuroendocrine changes include activation of the hypothalamo-pituitary-adrenal axis, sympathetic nervous system and alterations of s ... Full text Link to item Cite

Approaches to antifungal therapies and their effectiveness among patients with cryptococcosis.

Journal article Antimicrob Agents Chemother · June 2013 The goal of this study was to determine the degree to which the persistence of cryptococcosis, overall 1-year mortality, and 1-year mortality due to cryptococcosis were influenced by initial antifungal treatment regimen in a cohort of adults with cryptococ ... Full text Link to item Cite

"Code stroke": hospitalized versus emergency department patients.

Journal article J Stroke Cerebrovasc Dis · May 2013 Stroke rapid-response ("code stroke") teams facilitate the evaluation and treatment of patients presenting to emergency departments (EDs). Little is known about the usefulness of code stroke systems for patients hospitalized primarily for other conditions. ... Full text Link to item Cite

Depression and antidepressant use after stroke and transient ischemic attack.

Journal article Stroke · June 2012 BACKGROUND AND PURPOSE: Patients with stroke and transient ischemic attack (TIA) often have comparable comorbidities, but it is unclear whether they have similar rates of depression or antidepressant use. METHODS: This study was a secondary analysis of a p ... Full text Link to item Cite

Comparison and temporal trends of three groups with cryptococcosis: HIV-infected, solid organ transplant, and HIV-negative/non-transplant.

Journal article PLoS One · 2012 BACKGROUND: The Infectious Disease Society of America (IDSA) 2010 Clinical Practice Guidelines for the management of cryptococcosis outlined three key populations at risk of disease: (1) HIV-infected, (2) transplant recipient, and (3) HIV-negative/non-tran ... Full text Link to item Cite

[Neurology and cardiology: points of contact].

Journal article Rev Esp Cardiol · April 2011 Strokes resulting from cardiac diseases, and cardiac abnormalities associated with neuromuscular disorders are examples of the many points of contact between neurology and cardiology. Approximately 20-30% of strokes are related to cardiac diseases, includi ... Full text Link to item Cite

Concerns for the reliability and validity of the National Stroke Project Stroke Severity Scale.

Journal article Cerebrovasc Dis · 2011 BACKGROUND: The National Stroke Project (NSP) was a retrospective cohort study of US Medicare beneficiaries hospitalized with stroke or transient ischemic attack (TIA). The NSP included a simple assessment of stroke severity (NSP-Stroke Scale, NSP-SS). Use ... Full text Link to item Cite

Clinical application of blood biomarkers in cerebrovascular disease.

Journal article Expert Rev Neurother · February 2010 Identifying a biomarker or panel of biomarkers of cerebral ischemia would have a major impact on the care of stroke patients by facilitating early management decisions and individualization of care. Biochemical surrogates of cerebral ischemia might also pl ... Full text Link to item Cite

Echocardiographically detected mass "in transit" in early amniotic fluid embolism.

Journal article Eur J Echocardiogr · August 2006 BACKGROUND: Amniotic fluid embolism is a catastrophic illness related to the passage of fetal material into the pulmonary circulation causing cardiovascular collapse. CASE: A 29-year-old female sustained cardiopulmonary arrest during delivery presumably du ... Full text Link to item Cite