J. Victor Nadler

Journal article Neurosci Lett · February 2, 2007 Featured Publication Aspartate can be released from certain hippocampal pathways along with glutamate or GABA. Although aspartate immunoreactivity has been localized to synaptic vesicles and aspartate release is Ca(2+)-dependent, there has been no clear evidence favoring an ex ... Full text Link to item Cite

Neuropeptide Y in the recurrent mossy fiber pathway.

Journal article Peptides · February 2007 Featured Publication In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpressio ... Full text Link to item Cite

Spontaneous release of neuropeptide Y tonically inhibits recurrent mossy fiber synaptic transmission in epileptic brain.

Journal article J Neurosci · February 16, 2005 Featured Publication In the pilocarpine model of temporal lobe epilepsy, mossy fibers coexpress the inhibitory transmitter neuropeptide Y (NPY) with glutamate. The effects of endogenous and applied NPY on recurrent mossy fiber synaptic transmission were investigated with the u ... Full text Link to item Cite

Aspartate release from rat hippocampal synaptosomes.

Journal article Neuroscience · 2004 Featured Publication Certain excitatory pathways in the rat hippocampus can release aspartate along with glutamate. This study utilized rat hippocampal synaptosomes to characterize the mechanism of aspartate release and to compare it with glutamate release. Releases of asparta ... Full text Link to item Cite

The recurrent mossy fiber pathway of the epileptic brain.

Journal article Neurochem Res · November 2003 Featured Publication The dentate gyrus is believed to play a key role in the pathogenesis of temporal lobe epilepsy. In normal brain the dentate granule cells serve as a high-resistance gate or filter, inhibiting the propagation of seizures from the entorhinal cortex to the hi ... Full text Link to item Cite

Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain.

Journal article J Neurosci · June 15, 2003 Featured Publication The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in human temporal lobe epilepsy and in animal models of this disorder, creating monosynaptic connections among granule cells. This novel granule cell network can support reverberat ... Full text Link to item Cite

Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth.

Journal article J Neurophysiol · November 2000 Featured Publication The recurrent mossy fiber pathway of the dentate gyrus expands dramatically in many persons with temporal lobe epilepsy. The new connections among granule cells provide a novel mechanism of synchronization that could enhance the participation of these cell ... Full text Link to item Cite

Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation.

Journal article J Neurophysiol · October 1999 Featured Publication Dentate granule cells become synaptically interconnected in the hippocampus of persons with temporal lobe epilepsy, forming a recurrent mossy fiber pathway. This pathway may contribute to the development and propagation of seizures. The physiology of mossy ... Full text Link to item Cite

Recurrent mossy fiber pathway in rat dentate gyrus: synaptic currents evoked in presence and absence of seizure-induced growth.

Journal article J Neurophysiol · April 1999 Featured Publication A common feature of temporal lobe epilepsy and of animal models of epilepsy is the growth of hippocampal mossy fibers into the dentate molecular layer, where at least some of them innervate granule cells. Because the mossy fibers are axons of granule cells ... Full text Link to item Cite