Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Harvard University 1987
  • Ph.D., Massachusetts Institute of Technology 1985
  • B.S., Yale University 1980
  • M.S., Yale University 1980
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Pediatrics, Pediatrics, Clinical Science Departments 2007
• Recognition
• 

  In the News

  • JUL 26, 2016

    The News & Observer

    Duke medical dean to step down next year

  • JUL 22, 2016

    School of Medicine Dean Dr. Nancy Andrews to Step Down in 2017

  • JUN 26, 2015

    Allen Song Named Interim Director of Brain Institute

  • APR 29, 2015

    Medicine Dean Nancy Andrews Named to National Academy of Sciences

  • FEB 26, 2015

    Academic Leaders on the Troubled Future of Biomedical Research

  • JUN 25, 2014

    Fast Company

    How the dean of Duke's medical school is breaking down ‘invisible’ gender barriers

  • JUN 9, 2014

    Durham Herald-Sun

    Drs. Nancy Andrews and Edward Buckley: Making sure we have enough doctors

  • OCT 22, 2013

    Duke Receives $47 Million Award From NIH For Translational Research

  • AUG 1, 2013

    American Society of Hematology Honors SOM Dean Nancy Andrews

  • MAY 2, 2013

    National Report Calls for Reorganization of US Scientific Enterprise
• 

  Awards & Honors

  • Member, National Academy of Sciences. National Academy of Sciences. 2015
  • Henry M. Stratton Medal. American Society of Hematology. 2013
  • Marion Spencer Fay Award. Institute for Women's Health and Leadership. 2013
  • Mentor Award for Basic Science. American Society of Hematology. 2011
  • Spirit Award . National Institute of Environmental Health Sciences. 2011
  • Vanderbilt Prize in Biomedical Science. Vanderbilt University. 2010
  • President. American Society for Clinical Investigation (ASCI). 2009
  • Fellows. American Academy of Arts and Sciences. 2007
  • Marcel Simon Award. International BioIron Society. 2007
  • Fellow. American Association for the Advancement of Science. 2006
  • Member. National Academy of Medicine. 2006
  • Member. American Pediatric Society. 2004
  • Member. Association of American Physicians (AAP). 2004
  • E. Mead Johnson Award. Society for Pediatric Research. 2002
  • Outstanding Investigator Award in Basic Science. American Federation for Medical Research. 2000
  • Member. American Society for Clinical Investigation (ASCI). 1998
  • Investigator/Alumni Investigator. Howard Hughes Medical Institute. 1993
• Research
• 

  Selected Grants

  • Building Interdisciplinary Research Careers in Women's Health awarded by National Institutes of Health 2002 - 2022
  • Bridging the Gap to Enhance Clinical Research Program (BIGGER) awarded by National Institutes of Health 2016 - 2021
  • Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
  • Duke-UNC Clinical Hematology and Transfusion Research Career Development Program awarded by National Institutes of Health 2006 - 2019
  • Duke Research Training Program for Pediatricians awarded by National Institutes of Health 2002 - 2018
  • Center for Molecular & Cellular Studies of Ped Disease awarded by National Institutes of Health 2003 - 2018
  • School of Medicine 2017 Biddle awarded by Mary Duke Biddle Foundation 2017
  • NRSA Predoctoral Fellowship awarded by National Institutes of Health 2014 - 2017
  • Iron homeostasis in mammalian muscle awarded by National Institutes of Health 2011 - 2016
  • Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
  • Expansion of Animal Resources for Large Animals (Vivarium Expansion project) awarded by National Institutes of Health 2010 - 2015
  • Genes that modify Iron loading in mice awarded by National Institutes of Health 2004 - 2014
  • Identification of Novel Genes That Modulate Systemic Iron Homeostasis awarded by National Institutes of Health 2009 - 2013
  • Regulation of Iron Homeostasis awarded by National Institutes of Health 1998 - 2010
  • Erythroid Iron Transport awarded by National Institutes of Health 2008 - 2009
• 

  External Relationships

  • AlphaSights
  • Ambys Medicines, Inc
  • American Academy of Arts and Sciences
  • AstraZeneca
  • Burroughs Wellcome Fund - Foundation
  • Dyne Therapeutics
  • Massachusetts Institute of Technology
  • Novartis
  • Vida Ventures
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Matak, Pavle, Andrija Matak, Sarah Moustafa, Dipendra K. Aryal, Eric J. Benner, William Wetsel, and Nancy C. Andrews. “Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice.” Proc Natl Acad Sci U S A 113, no. 13 (March 29, 2016): 3428–35. https://doi.org/10.1073/pnas.1519473113.
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    • Jabara, Haifa H., Steven E. Boyden, Janet Chou, Narayanaswamy Ramesh, Michel J. Massaad, Halli Benson, Wayne Bainter, et al. “A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.” Nat Genet 48, no. 1 (January 2016): 74–78. https://doi.org/10.1038/ng.3465.
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    • Barrientos, Tomasa, Indira Laothamatas, Timothy R. Koves, Erik J. Soderblom, Miles Bryan, M Arthur Moseley, Deborah M. Muoio, and Nancy C. Andrews. “Metabolic Catastrophe in Mice Lacking Transferrin Receptor in Muscle.” Ebiomedicine 2, no. 11 (November 2015): 1705–17. https://doi.org/10.1016/j.ebiom.2015.09.041.
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    • Xu, Wenjing, Tomasa Barrientos, Lan Mao, Howard A. Rockman, Anthony A. Sauve, and Nancy C. Andrews. “Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart.” Cell Rep 13, no. 3 (October 20, 2015): 533–45. https://doi.org/10.1016/j.celrep.2015.09.023.
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    • Chen, Alan C., Adriana Donovan, Renee Ned-Sykes, and Nancy C. Andrews. “Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.” Proc Natl Acad Sci U S A 112, no. 37 (September 15, 2015): 11714–19. https://doi.org/10.1073/pnas.1511701112.
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    • Andrews, Nancy C. “Hungry irony.” J Clin Invest 125, no. 9 (September 2015): 3422–23. https://doi.org/10.1172/JCI83193.
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    • Levine, Arthur S., Robert J. Alpern, Nancy C. Andrews, Karen Antman, Jeffrey R. Balser, Jeremy M. Berg, Pamela B. Davis, et al. “Research in academic medical centers: two threats to sustainable support.” Sci Transl Med 7, no. 289 (May 27, 2015): 289fs22. https://doi.org/10.1126/scitranslmed.aac5200.
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    • “Women in metabolism: part I.” Cell Metab 21, no. 5 (May 5, 2015): 654–57. https://doi.org/10.1016/j.cmet.2015.04.017.
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    • Chen, Alan, Renee M. Ned, Adriana Donovan, and Nancy C. Andrews. “INACTIVATION OF TRANSFERRIN RECEPTOR (TFR1) IN THE PANCREAS RESULTS IN PANCREATITIS AND DIABETES.” American Journal of Hematology 88, no. 5 (May 1, 2013): E197–E197.
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    • Chen, Alan, Renee M. Ned, Adriana Donovan, and Nancy C. Andrews. “TRANSFERRIN RECEPTOR 1 (TFR1) IS REQUIRED FOR MAINTENANCE OF THE INTESTINAL EPITHELIUM.” American Journal of Hematology 88, no. 5 (May 1, 2013): E12–13.
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    • Xu, Wenjing, Tomasa Barrientos, and Nancy C. Andrews. “Iron and copper in mitochondrial diseases.” Cell Metab 17, no. 3 (March 5, 2013): 319–28. https://doi.org/10.1016/j.cmet.2013.02.004.
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    • Andrews, N. C., and V. N. Murti. “On soloists, symphonies, and transdisciplinary research.” Issues in Science and Technology 30, no. 1 (January 1, 2013): 30–32.
    • Prince, Olivier D., Jacqueline M. Langdon, Andrew J. Layman, Ian C. Prince, Miguel Sabogal, Howard H. Mak, Alan E. Berger, et al. “Late stage erythroid precursor production is impaired in mice with chronic inflammation.” Haematologica 97, no. 11 (November 2012): 1648–56. https://doi.org/10.3324/haematol.2011.053397.
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    • Hansen, Jakob Bondo, Morten Fog Tonnesen, Andreas Nygaard Madsen, Peter H. Hagedorn, Josefine Friberg, Lars Groth Grunnet, R Scott Heller, et al. “Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.” Cell Metab 16, no. 4 (October 3, 2012): 449–61. https://doi.org/10.1016/j.cmet.2012.09.001.
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    • Jin, Jie, Long-Jun Wu, Janice Jun, Xiping Cheng, Haoxing Xu, Nancy C. Andrews, and David E. Clapham. “The channel kinase, TRPM7, is required for early embryonic development.” Proc Natl Acad Sci U S A 109, no. 5 (January 31, 2012): E225–33. https://doi.org/10.1073/pnas.1120033109.
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    • Andrews, Nancy C. “Closing the iron gate.” N Engl J Med 366, no. 4 (January 26, 2012): 376–77. https://doi.org/10.1056/NEJMcibr1112780.
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    • Roberts, Kristina A., Victoria E. Abraira, Andrew F. Tucker, Lisa V. Goodrich, and Nancy C. Andrews. “Mutation of Rubie, a novel long non-coding RNA located upstream of Bmp4, causes vestibular malformation in mice.” Plos One 7, no. 1 (2012): e29495. https://doi.org/10.1371/journal.pone.0029495.
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    • Andrews, N. C. “Personalized medicine to anticipatory health.” Journal of Surgical Radiology 2, no. 3 (December 1, 2011): 220–23.
    • Andrews, Nancy C. “An iron-clad role for proteasomal degradation.” Cell Metab 14, no. 3 (September 7, 2011): 281–82. https://doi.org/10.1016/j.cmet.2011.08.001.
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    • Chen, Wenjie, Franklin W. Huang, Tomasa Barrientos de Renshaw, and Nancy C. Andrews. “Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis.” Blood 117, no. 23 (June 9, 2011): 6319–25. https://doi.org/10.1182/blood-2010-12-327957.
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    • Finberg, Karin E., Rebecca L. Whittlesey, and Nancy C. Andrews. “Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice.” Blood 117, no. 17 (April 28, 2011): 4590–99. https://doi.org/10.1182/blood-2010-10-315507.
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    • Bartnikas, Thomas B., Nancy C. Andrews, and Mark D. Fleming. “Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice.” Blood 117, no. 2 (January 13, 2011): 630–37. https://doi.org/10.1182/blood-2010-05-287359.
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    • Schmidt, Paul J., Nancy C. Andrews, and Mark D. Fleming. “Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin.” Blood 116, no. 25 (December 16, 2010): 5679–87. https://doi.org/10.1182/blood-2010-04-277954.
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    • Gardenghi, Sara, Pedro Ramos, Maria Franca Marongiu, Luca Melchiori, Laura Breda, Ella Guy, Kristen Muirhead, et al. “Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.” J Clin Invest 120, no. 12 (December 2010): 4466–77. https://doi.org/10.1172/JCI41717.
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    • Andrews, Nancy C. “Ferrit(in)ing out new mechanisms in iron homeostasis.” Cell Metab 12, no. 3 (September 8, 2010): 203–4. https://doi.org/10.1016/j.cmet.2010.08.011.
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    • Ferrucci, Luigi, Richard D. Semba, Jack M. Guralnik, William B. Ershler, Stefania Bandinelli, Kushang V. Patel, Kai Sun, et al. “Proinflammatory state, hepcidin, and anemia in older persons.” Blood 115, no. 18 (May 6, 2010): 3810–16. https://doi.org/10.1182/blood-2009-02-201087.
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    • Finberg, Karin E., Rebecca L. Whittlesey, Mark D. Fleming, and Nancy C. Andrews. “Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis.” Blood 115, no. 18 (May 6, 2010): 3817–26. https://doi.org/10.1182/blood-2009-05-224808.
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    • Cheng, Xiping, Jie Jin, Lily Hu, Dongbiao Shen, Xian-Ping Dong, Mohammad A. Samie, Jayne Knoff, et al. “TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.” Cell 141, no. 2 (April 16, 2010): 331–43. https://doi.org/10.1016/j.cell.2010.03.013.
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    • Andrews, N. C., and T. Ganz. “The Molecular Basis of Iron Metabolism,” March 10, 2010, 169–78. https://doi.org/10.1002/9781444318531.ch14.
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    • Andrews, Nancy C., Sally Kornbluth, and Doug Stokke. “Women: diversity among leaders is there if you look.” Nature 463, no. 7281 (February 4, 2010): 608. https://doi.org/10.1038/463608d.
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    • Andrews, Nancy C. “Can we keep the "academic" in academic medicine? 2009 American Society for Clinical Investigation Presidential Address.” J Clin Invest 120, no. 1 (January 2010): 390–93. https://doi.org/10.1172/JCI41934.
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    • Andrews, Nancy C. “Genes determining blood cell traits.” Nat Genet 41, no. 11 (November 2009): 1161–62. https://doi.org/10.1038/ng1109-1161.
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    • Andrews, Nancy C. “Build it and hope that enough of them will come.” J Clin Invest 119, no. 10 (October 2009): 2860–61. https://doi.org/10.1172/jci41105.
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    • Andrews, Nancy C. “ABCs of erythroid mitochondrial iron uptake.” Proc Natl Acad Sci U S A 106, no. 38 (September 22, 2009): 16012–13. https://doi.org/10.1073/pnas.0909137106.
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    • Carlson, Erik S., Ivan Tkac, Rhamy Magid, Michael B. O’Connor, Nancy C. Andrews, Timothy Schallert, Hiromi Gunshin, Michael K. Georgieff, and Anna Petryk. “Iron is essential for neuron development and memory function in mouse hippocampus.” J Nutr 139, no. 4 (April 2009): 672–79. https://doi.org/10.3945/jn.108.096354.
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    • Li, Jau Yi, Neal Paragas, Renee M. Ned, Andong Qiu, Melanie Viltard, Thomas Leete, Ian R. Drexler, et al. “Scara5 is a ferritin receptor mediating non-transferrin iron delivery.” Dev Cell 16, no. 1 (January 2009): 35–46. https://doi.org/10.1016/j.devcel.2008.12.002.
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    • Gardenghi, Sara, Maria Franca Marongiu, Kristen Muirhead, P. Ramos, Cindy N. Roy, Nancy C. Andrews, Elizabeta Nemeth, et al. “Increased Hepcidin Expression in Mice Affected by beta-Thalassemia Reduces Iron Overload with No Effect on Anemia.” Blood 112, no. 11 (November 16, 2008): 53–53.
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    • Jin, Jie, Bimal N. Desai, Betsy Navarro, Adriana Donovan, Nancy C. Andrews, and David E. Clapham. “Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis.” Science 322, no. 5902 (October 31, 2008): 756–60. https://doi.org/10.1126/science.1163493.
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    • Andrews, Nancy. “The science of climbing the academic ladder. Interview by Barbara Kantrowitz and Holly Peterson.” Newsweek 152, no. 15 (October 13, 2008): 72.
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    • Zhu, Bing-Mei, Sara K. McLaughlin, Risu Na, Jie Liu, Yongzhi Cui, Cyril Martin, Akiko Kimura, Gertraud W. Robinson, Nancy C. Andrews, and Lothar Hennighausen. “Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression.” Blood 112, no. 5 (September 1, 2008): 2071–80. https://doi.org/10.1182/blood-2007-12-127480.
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    • Andrews, Nancy C. “Forging a field: the golden age of iron biology.” Blood 112, no. 2 (July 15, 2008): 219–30. https://doi.org/10.1182/blood-2007-12-077388.
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    • Finberg, Karin E., Matthew M. Heeney, Dean R. Campagna, Yeşim Aydinok, Howard A. Pearson, Kip R. Hartman, Mary M. Mayo, et al. “Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA).” Nat Genet 40, no. 5 (May 2008): 569–71. https://doi.org/10.1038/ng.130.
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    • Liu, Sijin, Rajasekhar N. V. S. Suragani, Anping Han, Wanting Zhao, Nancy C. Andrews, and Jane-Jane Chen. “Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.” Haematologica 93, no. 5 (May 2008): 753–56. https://doi.org/10.3324/haematol.12175.
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    • Schmidt, Paul J., Paul T. Toran, Anthony M. Giannetti, Pamela J. Bjorkman, and Nancy C. Andrews. “The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression.” Cell Metab 7, no. 3 (March 2008): 205–14. https://doi.org/10.1016/j.cmet.2007.11.016.
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    • Wrighting, Diedra M., and Nancy C. Andrews. “Iron homeostasis and erythropoiesis.” Curr Top Dev Biol 82 (2008): 141–67. https://doi.org/10.1016/S0070-2153(07)00006-3.
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    • Andrews, Nancy C. “Climbing through medicine's glass ceiling.” N Engl J Med 357, no. 19 (November 8, 2007): 1887–89. https://doi.org/10.1056/NEJMp078198.
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    • Liu, Sijin, Rajasekhar N. V. S. Suragani, Fudi Wang, Anping Han, Wanting Zhao, Nancy C. Andrews, and Jane-Jane Chen. “The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation.” J Clin Invest 117, no. 11 (November 2007): 3296–3305. https://doi.org/10.1172/JCI32084.
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    • Wang, Fudi, Adam P. Lothrop, Nicholas G. James, Tanya A. M. Griffiths, Lisa A. Lambert, Rachael Leverence, Igor A. Kaltashov, Nancy C. Andrews, Ross T. A. MacGillivray, and Anne B. Mason. “A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase.” Biochem J 406, no. 1 (August 15, 2007): 85–95. https://doi.org/10.1042/BJ20070384.
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    • Wang, Fudi, Prasad N. Paradkar, Angel O. Custodio, Diane McVey Ward, Mark D. Fleming, Dean Campagna, Kristina A. Roberts, et al. “Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice.” Nat Genet 39, no. 8 (August 2007): 1025–32. https://doi.org/10.1038/ng2059.
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    • Babitt, Jodie L., Franklin W. Huang, Yin Xia, Yisrael Sidis, Nancy C. Andrews, and Herbert Y. Lin. “Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance.” J Clin Invest 117, no. 7 (July 2007): 1933–39. https://doi.org/10.1172/JCI31342.
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    • Gardenghi, Sara, Maria F. Marongiu, Pedro Ramos, Ella Guy, Laura Breda, Amy Chadburn, YiFang Liu, et al. “Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.” Blood 109, no. 11 (June 1, 2007): 5027–35. https://doi.org/10.1182/blood-2006-09-048868.
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    • Andrews, N. C. “Of mice and iron: Ferroportin disease.” Blood 109, no. 10 (May 15, 2007). https://doi.org/10.1182/blood-2007-02-075739.
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    • Roy, Cindy N., Howard H. Mak, Imo Akpan, Grigoriy Losyev, David Zurakowski, and Nancy C. Andrews. “Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation.” Blood 109, no. 9 (May 1, 2007): 4038–44. https://doi.org/10.1182/blood-2006-10-051755.
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    • Radoshitzky, Sheli R., Jonathan Abraham, Christina F. Spiropoulou, Jens H. Kuhn, Dan Nguyen, Wenhui Li, Jane Nagel, et al. “Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses.” Nature 446, no. 7131 (March 1, 2007): 92–96. https://doi.org/10.1038/nature05539.
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    • Andrews, Nancy C. “When is a heme transporter not a heme transporter? When it's a folate transporter.” Cell Metab 5, no. 1 (January 2007): 5–6. https://doi.org/10.1016/j.cmet.2006.12.004.
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    • Andrews, Nancy C., and Paul J. Schmidt. “Iron homeostasis.” Annu Rev Physiol 69 (2007): 69–85. https://doi.org/10.1146/annurev.physiol.69.031905.164337.
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    • Andrews, N. C. “Iron metabolism,” December 1, 2006, 848–53. https://doi.org/10.1007/978-1-59259-963-9_87.
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    • Andrews, N. C. “Iron Absorption” 2 (December 1, 2006): 1983–92. https://doi.org/10.1016/B978-012088394-3/50081-7.
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    • Wrighting, Diedra M., and Nancy C. Andrews. “Interleukin-6 induces hepcidin expression through STAT3.” Blood 108, no. 9 (November 1, 2006): 3204–9. https://doi.org/10.1182/blood-2006-06-027631.
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    • Goswami, Tapasree, and Nancy C. Andrews. “Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.” J Biol Chem 281, no. 39 (September 29, 2006): 28494–98. https://doi.org/10.1074/jbc.C600197200.
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    • Babitt, Jodie L., Franklin W. Huang, Diedra M. Wrighting, Yin Xia, Yisrael Sidis, Tarek A. Samad, Jason A. Campagna, et al. “Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression.” Nat Genet 38, no. 5 (May 2006): 531–39. https://doi.org/10.1038/ng1777.
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    • Donovan, Adriana, Cindy N. Roy, and Nancy C. Andrews. “The ins and outs of iron homeostasis.” Physiology (Bethesda) 21 (April 2006): 115–23. https://doi.org/10.1152/physiol.00052.2005.
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    • Viatte, Lydie, Gaël Nicolas, Dan-Qing Lou, Myriam Bennoun, Jeanne-Claire Lesbordes-Brion, François Canonne-Hergaux, Kai Schönig, et al. “Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice.” Blood 107, no. 7 (April 1, 2006): 2952–58. https://doi.org/10.1182/blood-2005-10-4071.
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    • Frazer, David M., Sarah J. Wilkins, Christopher D. Vulpe, and Gregory J. Anderson. “The role of duodenal cytochrome b in intestinal iron absorption remains unclear.” Blood 106, no. 13 (December 15, 2005): 4413. https://doi.org/10.1182/blood-2005-07-2923.
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    • Andrews, Nancy C. “Understanding heme transport.” N Engl J Med 353, no. 23 (December 8, 2005): 2508–9. https://doi.org/10.1056/NEJMcibr053987.
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    • Adams, Brian D., Rossitza Lazova, Nancy C. Andrews, and Leonard M. Milstone. “Iron in skin of mice with three etiologies of systemic iron overload.” J Invest Dermatol 125, no. 6 (December 2005): 1200–1205. https://doi.org/10.1111/j.0022-202X.2005.23949.x.
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    • Lim, Jackie E., Ou Jin, Carolyn Bennett, Kelly Morgan, Fudi Wang, Cameron C. Trenor, Mark D. Fleming, and Nancy C. Andrews. “A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice.” Nat Genet 37, no. 11 (November 2005): 1270–73. https://doi.org/10.1038/ng1659.
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    • Gunshin, Hiromi, Carolyn N. Starr, Cristina Direnzo, Mark D. Fleming, Jie Jin, Eric L. Greer, Vera M. Sellers, Stephanie M. Galica, and Nancy C. Andrews. “Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice.” Blood 106, no. 8 (October 15, 2005): 2879–83. https://doi.org/10.1182/blood-2005-02-0716.
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    • Gunshin, Hiromi, Jie Jin, Yuko Fujiwara, Nancy C. Andrews, Martha Mims, and Josef Prchal. “Analysis of the E399D mutation in SLC11A2.” Blood 106, no. 6 (September 15, 2005): 2221. https://doi.org/10.1182/blood-2005-03-1192.
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    • Huang, Franklin W., Jack L. Pinkus, Geraldine S. Pinkus, Mark D. Fleming, and Nancy C. Andrews. “A mouse model of juvenile hemochromatosis.” J Clin Invest 115, no. 8 (August 2005): 2187–91. https://doi.org/10.1172/JCI25049.
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    • Andrews, Nancy C., Sudha Anupindi, and Kamran Badizadegan. “Case records of the Massachusetts General Hospital. Case 21-2005. A four-week-old male infant with jaundice and thrombocytopenia.” N Engl J Med 353, no. 2 (July 14, 2005): 189–98. https://doi.org/10.1056/NEJMcpc059016.
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    • Andrews, Nancy C. “Molecular control of iron metabolism.” Best Pract Res Clin Haematol 18, no. 2 (June 2005): 159–69. https://doi.org/10.1016/j.beha.2004.10.004.
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    • Gunshin, Hiromi, Yuko Fujiwara, Angel O. Custodio, Cristina Direnzo, Sylvie Robine, and Nancy C. Andrews. “Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver.” J Clin Invest 115, no. 5 (May 2005): 1258–66. https://doi.org/10.1172/JCI24356.
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    • Tolosano, Emanuela, Sharmila Fagoonee, Cinzia Garuti, Linda Valli, Nancy C. Andrews, Fiorella Altruda, and Antonello Pietrangelo. “Haptoglobin modifies the hemochromatosis phenotype in mice.” Blood 105, no. 8 (April 15, 2005): 3353–55. https://doi.org/10.1182/blood-2004-07-2814.
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    • Donovan, Adriana, Christine A. Lima, Jack L. Pinkus, Geraldine S. Pinkus, Leonard I. Zon, Sylvie Robine, and Nancy C. Andrews. “The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.” Cell Metab 1, no. 3 (March 2005): 191–200. https://doi.org/10.1016/j.cmet.2005.01.003.
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    • Roy, Cindy N., and Nancy C. Andrews. “Anemia of inflammation: the hepcidin link.” Curr Opin Hematol 12, no. 2 (March 2005): 107–11. https://doi.org/10.1097/00062752-200503000-00001.
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    • Andrews, Nancy C. “Probing the iron pool. Focus on "Detection of intracellular iron by its regulatory effect".” Am J Physiol Cell Physiol 287, no. 6 (December 2004): C1537–38. https://doi.org/10.1152/ajpcell.00435.2004.
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    • Heeney, Matthew M., and Nancy C. Andrews. “Iron homeostasis and inherited iron overload disorders: an overview.” Hematol Oncol Clin North Am 18, no. 6 (December 2004): 1379–ix. https://doi.org/10.1016/j.hoc.2004.06.018.
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    • Andrews, Nancy C. “Pathophysiologic mechanisms of anemia of chronic disease.” Postgrad Med 116, no. 5 Suppl Anemia (November 2004): 17–22. https://doi.org/10.3810/pgm.11.2004.suppl36.250.
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    • Huang, Franklin W., Isabel Rubio-Aliaga, James P. Kushner, Nancy C. Andrews, and Mark D. Fleming. “Identification of a novel mutation (C321X) in HJV.” Blood 104, no. 7 (October 1, 2004): 2176–77. https://doi.org/10.1182/blood-2004-01-0400.
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    • Macedo, M Fatima, Maria de Sousa, Renee M. Ned, Claudia Mascarenhas, Nancy C. Andrews, and Margarida Correia-Neves. “Transferrin is required for early T-cell differentiation.” Immunology 112, no. 4 (August 2004): 543–49. https://doi.org/10.1111/j.1365-2567.2004.01915.x.
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    • Andrews, Nancy C. “Anemia of inflammation: the cytokine-hepcidin link.” J Clin Invest 113, no. 9 (May 2004): 1251–53. https://doi.org/10.1172/JCI21441.
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    • Roy, Cindy N., Angel O. Custodio, Jos de Graaf, Susanne Schneider, Imo Akpan, Lynne K. Montross, Mayka Sanchez, et al. “An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice.” Nat Genet 36, no. 5 (May 2004): 481–85. https://doi.org/10.1038/ng1350.
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    • Hentze, Matthias W., Martina U. Muckenthaler, and Nancy C. Andrews. “Balancing acts: molecular control of mammalian iron metabolism.” Cell 117, no. 3 (April 30, 2004): 285–97. https://doi.org/10.1016/s0092-8674(04)00343-5.
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    • Derjuga, Anna, Tania S. Gourley, Teresa M. Holm, Henry H. Q. Heng, Ramesh A. Shivdasani, Rafi Ahmed, Nancy C. Andrews, and Volker Blank. “Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus.” Mol Cell Biol 24, no. 8 (April 2004): 3286–94. https://doi.org/10.1128/mcb.24.8.3286-3294.2004.
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    • Miranda, Carlos J., Hortence Makui, Nancy C. Andrews, and Manuela M. Santos. “Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice.” Blood 103, no. 7 (April 1, 2004): 2847–49. https://doi.org/10.1182/blood-2003-09-3300.
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    • Nicolas, Gaël, Nancy C. Andrews, Axel Kahn, and Sophie Vaulont. “Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice.” Blood 103, no. 7 (April 1, 2004): 2841–43. https://doi.org/10.1182/blood-2003-09-3358.
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    • Xu, Haoxing, Jie Jin, Louis J. DeFelice, Nancy C. Andrews, and David E. Clapham. “A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway.” Plos Biol 2, no. 3 (March 2004): E50. https://doi.org/10.1371/journal.pbio.0020050.
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    • Donovan, Adriana, and Nancy Catherine Andrews. “The molecular regulation of iron metabolism.” Hematol J 5, no. 5 (2004): 373–80. https://doi.org/10.1038/sj.thj.6200540.
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    • Ned, Renee M., Wojciech Swat, and Nancy C. Andrews. “Transferrin receptor 1 is differentially required in lymphocyte development.” Blood 102, no. 10 (November 15, 2003): 3711–18. https://doi.org/10.1182/blood-2003-04-1086.
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    • Miranda, Carlos J., Hortence Makui, Ricardo J. Soares, Marc Bilodeau, Jeannie Mui, Hajatollah Vali, Richard Bertrand, Nancy C. Andrews, and Manuela M. Santos. “Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin.” Blood 102, no. 7 (October 1, 2003): 2574–80. https://doi.org/10.1182/blood-2003-03-0869.
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    • Braun, Anne, Songwen Zhang, Helena E. Miettinen, Shamsah Ebrahim, Teresa M. Holm, Eliza Vasile, Mark J. Post, et al. “Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor SR-BI/apolipoprotein E double knockout mouse.” Proc Natl Acad Sci U S A 100, no. 12 (June 10, 2003): 7283–88. https://doi.org/10.1073/pnas.1237725100.
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    • Muckenthaler, Martina, Cindy N. Roy, Angel O. Custodio, Belén Miñana, Jos deGraaf, Lynne K. Montross, Nancy C. Andrews, and Matthias W. Hentze. “Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis.” Nat Genet 34, no. 1 (May 2003): 102–7. https://doi.org/10.1038/ng1152.
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    • Nicolas, Gaël, Lydie Viatte, Dan-Qing Lou, Myriam Bennoun, Carole Beaumont, Axel Kahn, Nancy C. Andrews, and Sophie Vaulont. “Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis.” Nat Genet 34, no. 1 (May 2003): 97–101. https://doi.org/10.1038/ng1150.
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    • Roy, Cindy N., David A. Weinstein, and Nancy C. Andrews. “2002 E. Mead Johnson Award for Research in Pediatrics Lecture: the molecular biology of the anemia of chronic disease: a hypothesis.” Pediatr Res 53, no. 3 (March 2003): 507–12. https://doi.org/10.1203/01.PDR.0000049513.67410.2D.
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    • Santos, Manuela M., Carlos J. Miranda, Joanne E. Levy, Lynne K. Montross, Mireille Cossée, Jorge Sequeiros, Nancy Andrews, Michel Koenig, and Massimo Pandolfo. “Iron metabolism in mice with partial frataxin deficiency.” Cerebellum 2, no. 2 (2003): 146–53. https://doi.org/10.1080/14734220309408.
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    • Weinstein, David A., Cindy N. Roy, Mark D. Fleming, Massimo F. Loda, Joseph I. Wolfsdorf, and Nancy C. Andrews. “Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease.” Blood 100, no. 10 (November 15, 2002): 3776–81. https://doi.org/10.1182/blood-2002-04-1260.
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    • Andrews, Nancy C. “A genetic view of iron homeostasis.” Semin Hematol 39, no. 4 (October 2002): 227–34. https://doi.org/10.1053/shem.2002.35632.
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    • Ajioka, Richard S., Joanne E. Levy, Nancy C. Andrews, and James P. Kushner. “Regulation of iron absorption in Hfe mutant mice.” Blood 100, no. 4 (August 15, 2002): 1465–69. https://doi.org/10.1182/blood-2001-11-0037.
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    • Andrews, Nancy C. “The other physician-scientist problem: where have all the young girls gone?” Nat Med 8, no. 5 (May 2002): 439–41. https://doi.org/10.1038/nm0502-439.
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    • Andrews, Nancy C. “Metal transporters and disease.” Curr Opin Chem Biol 6, no. 2 (April 2002): 181–86. https://doi.org/10.1016/s1367-5931(02)00307-1.
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    • Holm, Teresa M., Anne Braun, Bernardo L. Trigatti, Carlo Brugnara, Masa Sakamoto, Monty Krieger, and Nancy C. Andrews. “Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI.” Blood 99, no. 5 (March 1, 2002): 1817–24. https://doi.org/10.1182/blood.v99.5.1817.
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    • Andrews, Nancy C. “Animal models of hereditary iron transport disorders.” Adv Exp Med Biol 509 (2002): 1–17. https://doi.org/10.1007/978-1-4615-0593-8_1.
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    • Gunshin, H., C. R. Allerson, M. Polycarpou-Schwarz, A. Rofts, J. T. Rogers, F. Kishi, M. W. Hentze, T. A. Rouault, N. C. Andrews, and M. A. Hediger. “Iron-dependent regulation of the divalent metal ion transporter.” Febs Lett 509, no. 2 (December 7, 2001): 309–16. https://doi.org/10.1016/s0014-5793(01)03189-1.
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    • Roy, C. N., and N. C. Andrews. “Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers.” Hum Mol Genet 10, no. 20 (October 1, 2001): 2181–86. https://doi.org/10.1093/hmg/10.20.2181.
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    • Montosi, G., A. Donovan, A. Totaro, C. Garuti, E. Pignatti, S. Cassanelli, C. C. Trenor, P. Gasparini, N. C. Andrews, and A. Pietrangelo. “Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene.” J Clin Invest 108, no. 4 (August 2001): 619–23. https://doi.org/10.1172/JCI13468.
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    • Andrews, N. C. “Mining copper transport genes.” Proc Natl Acad Sci U S A 98, no. 12 (June 5, 2001): 6543–45. https://doi.org/10.1073/pnas.131192498.
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    • Knutson, M. D., J. E. Levy, N. C. Andrews, and M. Wessling-Resnick. “Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice.” J Nutr 131, no. 5 (May 2001): 1459–64. https://doi.org/10.1093/jn/131.5.1459.
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    • Fleming, M. D., D. R. Campagna, J. N. Haslett, C. C. Trenor, and N. C. Andrews. “A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice.” Genes Dev 15, no. 6 (March 15, 2001): 652–57. https://doi.org/10.1101/gad.873001.
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    • Canonne-Hergaux, F., J. E. Levy, M. D. Fleming, L. K. Montross, N. C. Andrews, and P. Gros. “Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders.” Blood 97, no. 4 (February 15, 2001): 1138–40. https://doi.org/10.1182/blood.v97.4.1138.
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    • Sinclair, P. R., N. Gorman, H. S. Walton, W. J. Bement, J. F. Sinclair, G. S. Gerhard, J. G. Szakacs, N. C. Andrews, and J. E. Levy. “Uroporphyria in Hfe mutant mice given 5-aminolevulinate: a new model of Fe-mediated porphyria cutanea tarda.” Hepatology 33, no. 2 (February 2001): 406–12. https://doi.org/10.1053/jhep.2001.21409.
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    • Phillips, J. D., L. K. Jackson, M. Bunting, M. R. Franklin, K. R. Thomas, J. E. Levy, N. C. Andrews, and J. P. Kushner. “A mouse model of familial porphyria cutanea tarda.” Proc Natl Acad Sci U S A 98, no. 1 (January 2, 2001): 259–64. https://doi.org/10.1073/pnas.011481398.
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    • West, A. P., M. J. Bennett, V. M. Sellers, N. C. Andrews, C. A. Enns, and P. J. Bjorkman. “Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE.” J Biol Chem 275, no. 49 (December 8, 2000): 38135–38. https://doi.org/10.1074/jbc.C000664200.
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    • Andrews, N. C. “Inherited iron overload disorders.” Curr Opin Pediatr 12, no. 6 (December 2000): 596–602. https://doi.org/10.1097/00008480-200012000-00015.
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    • Andrews, N. C. “Iron metabolism and absorption.” Reviews in Clinical and Experimental Hematology 4, no. 4 (December 1, 2000): 283–301. https://doi.org/10.1046/j.1468-0734.2000.00021.x.
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    • Andrews, N. C. “Iron homeostasis: insights from genetics and animal models.” Nat Rev Genet 1, no. 3 (December 2000): 208–17. https://doi.org/10.1038/35042073.
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    • Canonne-Hergaux, F., M. D. Fleming, J. E. Levy, S. Gauthier, T. Ralph, V. Picard, N. C. Andrews, and P. Gros. “The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border.” Blood 96, no. 12 (December 1, 2000): 3964–70.
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    • Sayer, M. S., P. A. Tilbrook, A. Spadaccini, E. Ingley, M. K. Sarna, J. H. Williams, N. C. Andrews, and S. P. Klinken. “Ectopic expression of transcription factor NF-E2 alters the phenotype of erythroid and monoblastoid cells.” J Biol Chem 275, no. 33 (August 18, 2000): 25292–98. https://doi.org/10.1074/jbc.M908695199.
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    • Trenor, C. C., D. R. Campagna, V. M. Sellers, N. C. Andrews, and M. D. Fleming. “The molecular defect in hypotransferrinemic mice.” Blood 96, no. 3 (August 1, 2000): 1113–18.
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    • Levy, J. E., L. K. Montross, and N. C. Andrews. “Genes that modify the hemochromatosis phenotype in mice.” J Clin Invest 105, no. 9 (May 2000): 1209–16. https://doi.org/10.1172/JCI9635.
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    • Conrad, M. E., and J. N. Umbreit. “Disorders of iron metabolism.” N Engl J Med 342, no. 17 (April 27, 2000): 1293–94.
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    • Donovan, A., A. Brownlie, Y. Zhou, J. Shepard, S. J. Pratt, J. Moynihan, B. H. Paw, et al. “Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.” Nature 403, no. 6771 (February 17, 2000): 776–81. https://doi.org/10.1038/35001596.
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    • Andrews, N. C. “Iron metabolism: iron deficiency and iron overload.” Annu Rev Genomics Hum Genet 1 (2000): 75–98. https://doi.org/10.1146/annurev.genom.1.1.75.
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    • Andrews, N. C. “Iron metabolism: Iron deficiency and iron overload.” Annual Review of Genomics and Human Genetics 1, no. 2000 (2000): 75–98.
    • Andrews, N. C. “Intestinal iron absorption: current concepts circa 2000.” Dig Liver Dis 32, no. 1 (January 2000): 56–61. https://doi.org/10.1016/s1590-8658(00)80045-6.
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    • Andrews, N. C. “Disorders of iron metabolism.” N Engl J Med 341, no. 26 (December 23, 1999): 1986–95. https://doi.org/10.1056/NEJM199912233412607.
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    • Andrews, N. C. “The iron transporter DMT1.” Int J Biochem Cell Biol 31, no. 10 (October 1999): 991–94. https://doi.org/10.1016/s1357-2725(99)00065-5.
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    • Andrews, N. C., and M. D. Fleming. “Commentary on: ferrokinetics in the syndrome of familial hypoferremic microcytic anemia with iron malabsorption.” J Pediatr Hematol Oncol 21, no. 5 (September 1999): 353–55. https://doi.org/10.1097/00043426-199909000-00004.
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    • Levy, J. E., L. K. Montross, D. E. Cohen, M. D. Fleming, and N. C. Andrews. “The C282Y mutation causing hereditary hemochromatosis does not produce a null allele.” Blood 94, no. 1 (July 1, 1999): 9–11.
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    • Andrews, N. C., M. D. Fleming, and H. Gunshin. “Iron transport across biologic membranes.” Nutr Rev 57, no. 4 (April 1999): 114–23. https://doi.org/10.1111/j.1753-4887.1999.tb06934.x.
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    • Levy, J. E., O. Jin, Y. Fujiwara, F. Kuo, and N. C. Andrews. “Transferrin receptor is necessary for development of erythrocytes and the nervous system.” Nat Genet 21, no. 4 (April 1999): 396–99. https://doi.org/10.1038/7727.
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    • Andrews, N. C., M. D. Fleming, and J. E. Levy. “Molecular insights into mechanisms of iron transport.” Curr Opin Hematol 6, no. 2 (March 1999): 61–64. https://doi.org/10.1097/00062752-199903000-00001.
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    • Fleming, M. D., and N. C. Andrews. “Mammalian iron transport: an unexpected link between metal homeostasis and host defense.” J Lab Clin Med 132, no. 6 (December 1998): 464–68. https://doi.org/10.1016/s0022-2143(98)90123-8.
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    • Andrews, N. C., and J. E. Levy. “Iron is hot: an update on the pathophysiology of hemochromatosis.” Blood 92, no. 6 (September 15, 1998): 1845–51.
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    • Su, M. A., C. C. Trenor, J. C. Fleming, M. D. Fleming, and N. C. Andrews. “The G185R mutation disrupts function of the iron transporter Nramp2.” Blood 92, no. 6 (September 15, 1998): 2157–63.
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    • Yang, A., M. Kaghad, Y. Wang, E. Gillett, M. D. Fleming, V. Dötsch, N. C. Andrews, D. Caput, and F. McKeon. “p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.” Mol Cell 2, no. 3 (September 1998): 305–16. https://doi.org/10.1016/s1097-2765(00)80275-0.
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    • Versaw, W. K., V. Blank, N. M. Andrews, and E. H. Bresnick. “Mitogen-activated protein kinases enhance long-range activation by the beta-globin locus control region.” Proc Natl Acad Sci U S A 95, no. 15 (July 21, 1998): 8756–60. https://doi.org/10.1073/pnas.95.15.8756.
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    • Andrews, N. C. “The NF-E2 transcription factor.” Int J Biochem Cell Biol 30, no. 4 (April 1998): 429–32. https://doi.org/10.1016/s1357-2725(97)00135-0.
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    • Fleming, M. D., M. A. Romano, M. A. Su, L. M. Garrick, M. D. Garrick, and N. C. Andrews. “Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.” Proc Natl Acad Sci U S A 95, no. 3 (February 3, 1998): 1148–53. https://doi.org/10.1073/pnas.95.3.1148.
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    • Blank, V., and N. C. Andrews. “The Maf transcription factors: regulators of differentiation.” Trends Biochem Sci 22, no. 11 (November 1997): 437–41. https://doi.org/10.1016/s0968-0004(97)01105-5.
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    • Deveaux, S., S. Cohen-Kaminsky, R. A. Shivdasani, N. C. Andrews, A. Filipe, I. Kuzniak, S. H. Orkin, P. H. Roméo, and V. Mignotte. “p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes.” Embo J 16, no. 18 (September 15, 1997): 5654–61. https://doi.org/10.1093/emboj/16.18.5654.
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    • Blank, V., J. H. Knoll, and N. C. Andrews. “Molecular characterization and localization of the human MAFG gene.” Genomics 44, no. 1 (August 15, 1997): 147–49. https://doi.org/10.1006/geno.1997.4847.
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    • Fleming, M. D., C. C. Trenor, M. A. Su, D. Foernzler, D. R. Beier, W. F. Dietrich, and N. C. Andrews. “Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.” Nat Genet 16, no. 4 (August 1997): 383–86. https://doi.org/10.1038/ng0897-383.
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    • Blank, V., M. J. Kim, and N. C. Andrews. “Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression.” Blood 89, no. 11 (June 1, 1997): 3925–35.
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    • Andrews, N. C. “Iron deficiency: lessons from anemic mice.” Yale J Biol Med 70, no. 3 (May 1997): 219–26.
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    • Cheng, X., M. J. Reginato, N. C. Andrews, and M. A. Lazar. “The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2.” Mol Cell Biol 17, no. 3 (March 1997): 1407–16. https://doi.org/10.1128/mcb.17.3.1407.
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    • Andrews, N. C., and C. M. Bennett. “Disorders of red cell iron during infancy and childhood.” International Journal of Pediatric Hematology/Oncology 4, no. 2 (January 1, 1997): 171–80.
    • Walters, M., N. C. Andrews, W. Magis, and D. I. Martin. “Erythroid AP-1/NF-E2 elements vary in their response to NF-E2.” Exp Hematol 24, no. 3 (February 1996): 445–52.
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    • Parsons, S. K., M. D. Fleming, D. Phil, D. G. Nathan, and N. C. Andrews. “Iron deficiency anemia associated with an error of iron metabolism in two siblings: A thirty year follow up.” Hematology 1, no. 1 (January 1, 1996): 65–73. https://doi.org/10.1080/10245332.1996.11746287.
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    • Engeland, K., N. C. Andrews, and B. Mathey-Prevot. “Multiple proteins interact with the nuclear inhibitory protein repressor element in the human interleukin-3 promoter.” J Biol Chem 270, no. 41 (October 13, 1995): 24572–79. https://doi.org/10.1074/jbc.270.41.24572.
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    • Garingo, A. D., M. Suhasini, N. C. Andrews, and R. B. Pilz. “cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation.” J Biol Chem 270, no. 16 (April 21, 1995): 9169–77. https://doi.org/10.1074/jbc.270.16.9169.
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    • Ney, P. A., S. F. Farina, D. M. Bodine, N. C. Andrews, S. H. Orkin, and A. W. Neinhuis. “Microcytic anemia in mk/mk mice is not corrected by retroviral-mediated gene transfer of wild-type p45 NF-E2.” Exp Hematol 23, no. 1 (January 1995): 74–80.
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    • Trenor, C., W. Lin, and N. C. Andrews. “Novel bacterial P-type ATPases with histidine-rich heavy-metal-associated sequences.” Biochem Biophys Res Commun 205, no. 3 (December 30, 1994): 1644–50. https://doi.org/10.1006/bbrc.1994.2856.
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    • Andrews, N. C. “Erythroid transcription factor NF-E2 coordinates hemoglobin synthesis.” Pediatr Res 36, no. 4 (October 1994): 419–23. https://doi.org/10.1203/00006450-199410000-00001.
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    • Lim, K. C., H. Ishihara, R. D. Riddle, Z. Yang, N. Andrews, M. Yamamoto, and J. D. Engel. “Structure and regulation of the chicken erythroid delta-aminolevulinate synthase gene.” Nucleic Acids Res 22, no. 7 (April 11, 1994): 1226–33. https://doi.org/10.1093/nar/22.7.1226.
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    • Andrews, N. C., and S. H. Orkin. “Transcriptional control of erythropoiesis.” Curr Opin Hematol 1, no. 2 (March 1994): 119–24.
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    • Peters, L. L., N. C. Andrews, E. M. Eicher, M. B. Davidson, S. H. Orkin, and S. E. Lux. “Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2 [8].” Nature 371, no. 6495 (January 1, 1994). https://doi.org/10.1038/371358b0.
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    • Peters, L. L., N. C. Andrews, E. M. Eicher, M. B. Davidson, S. H. Orkin, and S. E. Lux. “Erratum: Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2 (Nature 362, 768-770 (1992)).” Nature 371, no. 6495 (1994).
    • Andrews, N. C., K. J. Kotkow, P. A. Ney, H. Erdjument-Bromage, P. Tempst, and S. H. Orkin. “The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.” Proc Natl Acad Sci U S A 90, no. 24 (December 15, 1993): 11488–92. https://doi.org/10.1073/pnas.90.24.11488.
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    • Ney, P. A., N. C. Andrews, S. M. Jane, B. Safer, M. E. Purucker, S. Weremowicz, C. C. Morton, S. C. Goff, S. H. Orkin, and A. W. Nienhuis. “Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner.” Mol Cell Biol 13, no. 9 (September 1993): 5604–12. https://doi.org/10.1128/mcb.13.9.5604.
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    • Andrews, N. C., H. Erdjument-Bromage, M. B. Davidson, P. Tempst, and S. H. Orkin. “Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein.” Nature 362, no. 6422 (April 22, 1993): 722–28. https://doi.org/10.1038/362722a0.
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    • Peters, L. L., N. C. Andrews, E. M. Eicher, M. B. Davidson, S. H. Orkin, and S. E. Lux. “Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2.” Nature 362, no. 6422 (April 22, 1993): 768–70. https://doi.org/10.1038/362768a0.
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    • Liboi, E., P. Jubinsky, N. C. Andrews, D. G. Nathan, and B. Mathey-Prevot. “Enhanced expression of interleukin-3 and granulocyte-macrophage colony-stimulating factor receptor subunits in murine hematopoietic cells stimulated with hematopoietic growth factors.” Blood 80, no. 5 (September 1, 1992): 1183–89.
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    • Strauss, E. C., N. C. Andrews, D. R. Higgs, and S. H. Orkin. “In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.” Mol Cell Biol 12, no. 5 (May 1992): 2135–42. https://doi.org/10.1128/mcb.12.5.2135.
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    • Andrews, N. C., and D. V. Faller. “A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.” Nucleic Acids Res 19, no. 9 (May 11, 1991): 2499. https://doi.org/10.1093/nar/19.9.2499.
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    • Mathey-Prevot, B., N. C. Andrews, H. S. Murphy, S. G. Kreissman, and D. G. Nathan. “Positive and negative elements regulate human interleukin 3 expression.” Proc Natl Acad Sci U S A 87, no. 13 (July 1990): 5046–50. https://doi.org/10.1073/pnas.87.13.5046.
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    • ANDREWS, N. C., B. MATHEYPREVOT, S. G. KREISSMAN, and D. G. NATHAN. “NUCLEAR FACTOR BINDING-SITES IN THE INTERLEUKIN (IL-3) PROMOTER.” Pediatric Research 27, no. 4 (April 1, 1990): A138–A138.
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    • Andrews, N. C., B. Mathey-Prevot, H. Murphy, and D. G. Nathan. “Regulation of the human interleukin-3 gene.” Trans Assoc Am Physicians 102 (1989): 240–51.
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    • Andrews, N. C., and D. Baltimore. “Lack of evidence for VPg priming of poliovirus RNA synthesis in the host factor-dependent in vitro replicase reaction.” J Virol 58, no. 1 (April 1986): 212–15.
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    • Andrews, N. C., and D. Baltimore. “Purification of a terminal uridylyltransferase that acts as host factor in the in vitro poliovirus replicase reaction.” Proc Natl Acad Sci U S A 83, no. 2 (January 1986): 221–25. https://doi.org/10.1073/pnas.83.2.221.
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    • Andrews, N. C., D. Levin, and D. Baltimore. “Poliovirus replicase stimulation by terminal uridylyl transferase.” J Biol Chem 260, no. 12 (June 25, 1985): 7628–35.
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    • Rosa, M. D., and N. C. Andrews. “Phage T3 DNA contains an exact copy of the 23 base-pair phage T7 RNA polymerase promoter sequence.” J Mol Biol 147, no. 1 (March 25, 1981): 41–53. https://doi.org/10.1016/0022-2836(81)90078-4.
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    • Lerner, M. R., N. C. Andrews, G. Miller, and J. A. Steitz. “Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus.” Proc Natl Acad Sci U S A 78, no. 2 (February 1981): 805–9. https://doi.org/10.1073/pnas.78.2.805.
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  • Conference Papers

    • Stagg, David B., Sara Gardenghi, Stefano Rivella, Nancy C. Andrews, and Karin E. Finberg. “Genetic Loss of Tmprss6 Increases Effective Erythropoiesis in a Mouse Model of β-Thalassemia.” In Blood, 120:482–482. American Society of Hematology, 2012. https://doi.org/10.1182/blood.v120.21.482.482.
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    • Stagg, David B., Sara Gardenghi, Stefano Rivella, Nancy C. Andrews, and Karin E. Finberg. “Genetic Loss of Tmprss6 Increases Effective Erythropoiesis in a Mouse Model of beta-Thalassemia.” In Blood, Vol. 120. AMER SOC HEMATOLOGY, 2012.
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    • Finberg, Karin E., Rebecca L. Whittlesey, Stefano Rivella, and Nancy C. Andrews. “Tmprss6, An Inhibitor of Hepatic Bmp/Smad Signaling, Is Required for Hepcidin Suppression and Iron Loading In a Mouse Model of beta-Thalassemia.” In Blood, 116:75–75. AMER SOC HEMATOLOGY, 2010.
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    • Gardenghi, Sara, Pedro Ramos, Cindy N. Roy, Nancy C. Andrews, Elizabeta Nemeth, Xiuhi An, Mohandas Narla, et al. “Hepcidin as a Therapeutic Tool to Limit Iron Overload and Improve Anemia In beta-Thalassemia.” In Blood, 116:443–44. AMER SOC HEMATOLOGY, 2010.
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    • Wehbe, Ramsey M., Rebecca L. Whittlesey, Nancy C. Andrews, and Karin E. Finberg. “The Serine Protease Tmprss6 Regulates Hepcidin Expression, but Its Loss Does Not Cause Systemic Iron Deficiency In the Fetal and Neonatal Periods.” In Blood, 116:1728–1728. AMER SOC HEMATOLOGY, 2010.
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    • Finberg, Karin E., Rebecca Whittlesey, Mark D. Fleming, and Nancy C. Andrews. “Tmprss6 Is a Genetic Modifier of the Hfe-Hemochromatosis Phenotype in Mice.” In Blood, 114:259–259. AMER SOC HEMATOLOGY, 2009.
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