Journal articleSleep Epidemiology · December 1, 2026
Background Obesity hypoventilation syndrome (OHS) is underdiagnosed in ethnically diverse populations where Western-derived screening guidelines may not apply. This systematic review synthesizes evidence from South Asian and selected Western cohorts to cha ...
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Journal articleSleep Epidemiology · December 1, 2026
Background Idiopathic/isolated REM sleep behavior disorder (iRBD) serves as a prodromal marker for alpha-synucleinopathies, with most patients developing neurodegenerative disease over time. The prevalence and clinical significance of concurrent periodic l ...
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Journal articleCurrent Sleep Medicine Reports · December 1, 2026
Purpose of Review: Periodic limb movements during sleep (PLMS) are linked to sympathetic activation and sleep fragmentation, mechanisms implicated in dysglycemia, but whether PLMS is a risk factor for diabetes mellitus (DM) is unclear. We searched MEDLINE, ...
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Journal articleExpert Rev Respir Med · October 2026
INTRODUCTION: Interstitial lung disease (ILD) is characterized by chronic inflammation and fibrosis, with emerging evidence suggesting increased venous thromboembolism (VTE) risk. We conducted a systematic review and meta-analysis to quantify VTE risk in I ...
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Journal articleThromb Haemost · September 21, 2026
BACKGROUND: Chronic corticosteroid use is prevalent among surgical patients, yet its association with postoperative venous thromboembolism (VTE) has not been systematically quantified. We conducted a systematic review and meta-analysis to assess this risk. ...
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Journal articleExpert Opin Pharmacother · September 2026
BACKGROUND: Perioperative corticosteroids suppress pro-inflammatory pathways that drive postoperative coagulation, suggesting a potential anti-thrombotic effect. No prior systematic review has examined this relationship. METHODS: We systematically reviewed ...
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Journal articleJ Sleep Res · August 2026
Obstructive sleep apnea (OSA) has been poorly characterised in patients with bronchiectasis despite potential bidirectional clinical impacts. This systematic review and meta-analysis determined the prevalence of OSA confirmed by polysomnography in cystic f ...
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Journal articleSleep Med · August 2026
BACKGROUND: Commercial wearable devices increasingly monitor sleep, but their concordance with patient-reported sleep quality remains poorly characterized. This systematic review evaluates concordance between wearable sleep metrics and validated subjective ...
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Journal articleExpert Rev Respir Med · June 2026
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) significantly increases lung cancer risk, with cumulative incidence exceeding 50% at 10 years. We evaluated whether antifibrotic therapies provide cancer-protective effects beyond their established antifibrot ...
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Journal articleExpert Opin Pharmacother · June 2026
INTRODUCTION: Glucocorticoids (GCs) are among the most widely prescribed medications globally. Despite biological plausibility for procoagulant effects, the magnitude of venous thromboembolism (VTE) risk has not been rigorously quantified. We conducted a s ...
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Journal articleRespir Investig · May 2026
BACKGROUND: Volume-assured pressure support (VAPS) modes automatically adjust inspiratory pressure to maintain target ventilation, theoretically improving upon traditional bilevel positive airway pressure (BiPAP). However, their comparative effectiveness a ...
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Journal articleSleep Breath · March 3, 2026
BACKGROUND: Periodic limb movements in sleep (PLMS) have been associated with cardiovascular morbidity, but their relationship with stroke remains incompletely understood. This systematic review and meta-analysis evaluated the association between PLMS and ...
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Journal articleSleep Biol Rhythms · January 2026
UNLABELLED: REM sleep behavior disorder (RBD) frequently co-occurs with obstructive sleep apnea (OSA), with up to 90% of RBD patients having concurrent OSA. OSA-related sleep fragmentation may exacerbate RBD symptoms through disruption of REM sleep archite ...
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Journal articleHeart Lung · 2026
BACKGROUND: Hypersensitivity pneumonitis (HP) represents a significant diagnostic challenge in interstitial lung disease, where serological testing plays a crucial yet often misinterpreted role. OBJECTIVES: To systematically evaluate the diagnostic accurac ...
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Journal articleRespir Investig · September 2025
BACKGROUND: Acute exacerbations of interstitial lung disease (AE-ILD) are associated with significant morbidity and mortality. While corticosteroids are commonly used in the treatment, their optimal dose, duration, and overall benefit remain unclear. This ...
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Journal articleSleep Breath · May 1, 2025
BACKGROUND: Obstructive sleep apnea (OSA) is a prevalent sleep disorder associated with intermittent hypoxia, sleep fragmentation, and systemic inflammation, all of which may influence cancer development. Continuous positive airway pressure (CPAP) therapy ...
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Journal articleJ Clin Neurosci · March 2025
INTRODUCTION: Obstructive sleep apnea (OSA) is characterized by repetitive episodes of complete or partial upper airway collapse during sleep. Restless legs syndrome (RLS) is a sleep-related movement disorder characterized by an uncomfortable urge to move ...
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Journal articleThorax · February 17, 2025
INTRODUCTION: Acute exacerbation of interstitial lung disease (AE-ILD) often results in death and poses significant challenges in clinical management. While corticosteroids are frequently employed, the optimal regimen and their clinical efficacy remain unc ...
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Journal articleHeart Lung · 2025
BACKGROUND: Acute exacerbation of interstitial lung disease (AE-ILD) is a severe respiratory complication with overlapping clinical features that make distinguishing it from bacterial infections challenging. OBJECTIVES: Evaluate procalcitonin's (PCT) diagn ...
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Journal articleHeart Lung · 2025
BACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) undergoing lung cancer surgery face a 4.4-20 % risk of acute exacerbation (AE-IPF) with mortality exceeding 50 %. The potential role of perioperative antifibrotic therapy in reducing surgical co ...
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Journal articleSleep Breath · August 2024
PURPOSE: Interstitial lung disease (ILD) often coexists with obstructive sleep apnea (OSA), contributing to increased morbidity and mortality. However, the effectiveness of continuous positive airway pressure (CPAP) therapy in this population remains uncle ...
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Journal articleJ Am Heart Assoc · February 6, 2024
BACKGROUND: Obstructive sleep apnea is a well-established risk factor for cardiovascular disease (CVD). Recent studies have also linked periodic limb movements during sleep to CVD. We aimed to determine whether periodic limb movements during sleep and obst ...
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Journal articleSleep Med · August 2023
BACKGROUND: The co-occurrence of obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD), known as COPD-OSA overlap syndrome, increases morbidity and mortality. The effectiveness of continuous positive airway pressure (CPAP) therapy, ...
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Journal articleSleep Med · February 2023
BACKGROUND: Several studies suggest an association between periodic limb movements during sleep (PLMS) and hypertension; however, a systematic evaluation of this relationship is lacking. METHODS: We conducted a systematic review and meta-analysis of observ ...
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Journal articlePostgrad Med J · January 2022
BACKGROUND: We aimed to report the incidence of hospital-acquired hypophosphataemia and hyperphosphataemia along with their associated in-hospital mortality. METHODS: We included 15 869 adult patients hospitalised at a tertiary medical referral centre from ...
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Journal articleJ Pers Med · November 2, 2021
BACKGROUND: Lactic acidosis is a heterogeneous condition with multiple underlying causes and associated outcomes. The use of multi-dimensional patient data to subtype lactic acidosis can personalize patient care. Machine learning consensus clustering may i ...
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Journal articleJ Clin Med · October 28, 2021
BACKGROUND: Lactic acidosis is the most common cause of anion gap metabolic acidosis in the intensive care unit (ICU), associated with poor outcomes including mortality. We sought to compare machine learning (ML) approaches versus logistic regression analy ...
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Journal articleMedicina (Kaunas) · March 1, 2020
Background and objectives: Goodpasture's syndrome (GS) is a rare, life-threatening autoimmune disease. Although the coexistence of anti-neutrophil cytoplasmic antibody (ANCA) with Goodpasture's syndrome has been recognized, the impacts of ANCA vasculitis o ...
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Journal articleJ Clin Med · February 6, 2020
Background: Goodpasture's syndrome is a rare, life-threatening, small vessel vasculitis. Given its rarity, data on its inpatient burden and resource utilization are lacking. We conducted this study aiming to assess inpatient prevalence, mortality, and reso ...
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Journal articleJ Clin Med · October 17, 2019
BACKGROUND: Lung transplantation has been increasingly performed worldwide and is considered an effective therapy for patients with various causes of end-stage lung diseases. We performed a systematic review to assess the incidence and impact of acute kidn ...
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Journal articleJ Clin Sleep Med · October 15, 2019
STUDY OBJECTIVES: A strong association between sleep-disordered breathing (SDB) and atrial fibrillation and/or atrial flutter (AF) has consistently been observed in epidemiologic and interventional studies. The effect of positive airway pressure (PAP) on A ...
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Journal articleJ Clin Med · July 5, 2019
BACKGROUND: Although acute kidney injury (AKI) is a frequent complication in patients receiving extracorporeal membrane oxygenation (ECMO), the incidence and impact of AKI on mortality among patients on ECMO remain unclear. We conducted this systematic rev ...
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Journal articleJ Evid Based Med · August 2018
BACKGROUND/OBJECTIVES: Patients with obstructive sleep apnea (OSA) have an increased the risk of developing atrial fibrillation (AF). However, it remains unclear if patients with OSA carry a higher risk of recurrent AF after successful catheter ablation. T ...
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Journal articleRen Fail · November 2017
BACKGROUND: The aim of this study was to compare the incidence of post-procedural acute kidney injury (AKI) and other renal outcomes in patients undergoing transapical (TA) and transfemoral (TF) approaches for transcatheter aortic valve replacement (TAVR). ...
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Journal articleJ Card Surg · September 2017
BACKGROUND: Acute kidney injury (AKI) and its severity after transcatheter aortic valve replacement (TAVR) have been associated with worse outcomes. Studies have shown that AKI duration (transient or persistent) affects outcomes independently of AKI severi ...
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Journal articleInt J Cardiol · August 15, 2017
BACKGROUND: Growing evidence indicates that periodic limb movements of sleep (PLMS) may be related to increased risk of developing cardiovascular disease. However, the association of PLMS with atrial fibrillation (AF) is unclear, especially in patients wit ...
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Journal articleNephrol Dial Transplant · June 1, 2017
BACKGROUND: The risks of proteinuria and chronic kidney disease (CKD) in adults who regularly have short sleep duration (short sleepers) are controversial. The aim of this meta-analysis was to assess the effects of short sleep duration on proteinuria and C ...
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Journal articleQJM · May 1, 2017
BACKGROUND: Pulmonary artery sarcoma (PAS) is a rare malignant neoplasm with an aggressive behavior and often difficult to distinguish from pulmonary thromboembolic disease. AIM: To assess the demographic, clinical, and radiological characteristics of PAS ...
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Journal articleInt J Rheum Dis · April 2017
AIMS: Patients with rheumatoid arthritis (RA) might be at an increased risk of developing atrial fibrillation (AF) as a result of deleterious effects of inflammatory cytokines on cardiomyocytes. This study aimed to comprehensively review all available evid ...
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Journal articlePLoS One · 2017
BACKGROUND: This study aimed to examine the association between renal recovery status at hospital discharge after acute kidney injury (AKI) and long-term mortality following transcatheter aortic valve replacement (TAVR). METHODS: We screened all adult pati ...
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Journal articleJournal of Renal Injury Prevention · January 1, 2017
Introduction: The patients selected for transcatheter aortic valve replacement (TAVR) usually have a high prevalence of chronic kidney disease (CKD). Little is known regarding the impact of TAVR on changes in renal function. Objectives: This study aimed to ...
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Journal articleNephrology (Carlton) · December 2016
AIM: This study aimed to determine the incidence and risk factors of acute kidney injury (AKI) following transcatheter aortic valve replacement (TAVR). METHODS: We included all adult patients undergoing TAVR for aortic stenosis from 1 January 2008 to 30 Ju ...
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Journal articleJ Evid Based Med · November 2016
OBJECTIVE: The risk of hypertension in adults who regularly take a nap is controversial. The objective of this meta-analysis was to assess the associations between napping and hypertension. METHODS: A literature search was performed using MEDLINE, EMbase a ...
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Journal articleJ Dermatolog Treat · August 2016
Psoriasis has been linked to an increased risk of several co-morbidities. However, its association with chronic obstructive pulmonary disease (COPD) remains unclear. To further characterize this relationship, we conducted a systematic review and meta-analy ...
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Journal articleInt J Rheum Dis · August 2016
AIM: To investigate the association between giant cell arteritis (GCA) and risk of peripheral arterial disease (PAD). METHODS: We conducted a systematic review and meta-analysis of observational cohort studies that reported relative risks, hazard ratios or ...
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Journal articleJ Clin Neurosci · July 2016
Although amyotrophic lateral sclerosis (ALS) does not directly affect the lung parenchyma, it can jeopardize the mechanical function of the respiratory system. About one-quarter of ALS patients have had at least one prior misdiagnosis. Therefore, a high cl ...
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Journal articleJ Am Soc Nephrol · June 2016
Transcatheter aortic valve replacement (TAVR) is an alternative to surgical aortic valve replacement (SAVR) for patients with symptomatic severe aortic stenosis who are at high risk of perioperative mortality. Previous studies showed increased risk of post ...
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Journal articleIndian J Hematol Blood Transfus · June 2016
A case of 44-year-old man with dyspnea and CT chest demonstrated bilateral infiltration. Patient was failed to improve with antibiotics and steroid. Finally, video-assisted thoracic surgery-guided lung biopsy was performed and surprisingly revealed intrava ...
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Journal articleBMC Pharmacol Toxicol · May 7, 2016
BACKGROUND: The choice of vasopressor use in the intensive care unit (ICU) depends primarily on provider preference. This study aims to describe the rate of vasopressor utilization and the trends of each vasoactive agent usage in the ICU over the span of 7 ...
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Journal articleJoint Bone Spine · May 2016
OBJECTIVE: To investigate the risk of subsequent development of chronic obstructive pulmonary disease (COPD) in patients with rheumatoid arthritis (RA). METHODS: We conducted a systematic review and meta-analysis of cohort studies that reported relative ri ...
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Journal articleJ Nephrol · April 2016
BACKGROUND: Fluid accumulation may delay recognition of acute kidney injury (AKI) in intensive care unit (ICU) patients. This study aims to evaluate the impact of fluid balance on the incidence, time of AKI diagnosis and predictive performance for outcomes ...
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Journal articleClin Cardiol · February 2016
BACKGROUND: The association between the development of heart failure (HF) and use of nonsteroidal anti-inflammatory drugs (NSAIDs) is not well established. HYPOTHESIS: Use of NSAIDs may increase the risk of incident HF. METHODS: We conducted a systematic r ...
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Journal articleBMC Nephrol · January 9, 2016
BACKGROUND: Baseline serum creatinine (SCr) level is frequently not measured in clinical practice. The aim of this study was to investigate the effect of various methods of baseline SCr determination measurement on accuracy of acute kidney injury (AKI) dia ...
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Journal articleLung India · 2016
BACKGROUND: Several immune-mediated inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus have been linked to an increased risk of venous thromboembolism (VTE). However, the data on ankylosing spondylit ...
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Journal articleNeurol India · 2016
BACKGROUND: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to an increased risk of cerebrovascular accident (CVA), but the data on polymyalgia rheumatica (PMR) remains unclear. MATERI ...
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Journal articleIndian J Dermatol Venereol Leprol · 2016
BACKGROUND AND OBJECTIVES: Patients with psoriasis might have a higher risk of developing atrial fibrillation as a result of chronic inflammation. This study aimed to investigate this association by comprehensively reviewing all available evidence. METHODS ...
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Journal articleIndian J Dermatol · 2016
BACKGROUND: Patients with psoriasis might be at a higher risk of developing Parkinson's disease (PD) as a result of the detrimental effect of chronic inflammation on the neuronal tissue. This meta-analysis aimed to investigate this risk by comprehensively ...
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Journal articleNephrology (Carlton) · December 2015
AIM: This study aimed to investigate how varied methods of determining baseline serum creatinine (SCr) would affect acute kidney injury (AKI) diagnosis and prediction of 60 day mortality in critically ill patients following an episode of AKI. METHODS: This ...
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Journal articleThromb Res · November 2015
OBJECTIVE: To investigate the risk of venous thromboembolism (VTE) among patients with autoimmune hemolytic anemia (AIHA). METHODS: We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ...
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Journal articleEur J Intern Med · November 2015
BACKGROUND: The association between exacerbation of heart failure (HF) and use of non-steroidal anti-inflammatory drugs (NSAIDs) has long been recognized but the data on this adverse effect are limited. METHODS: To further characterize this possible associ ...
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Journal articleMod Rheumatol · November 2015
BACKGROUND: Several chronic inflammatory disorders, such as rheumatoid arthritis, inflammatory myositis, and systemic vasculitides, have been linked to an increased risk of venous thromboembolism (VTE). However, the data on systemic sclerosis (SSc) remains ...
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Journal articleInt J Clin Pract · November 2015
BACKGROUND: The association between admission serum magnesium (Mg) levels and risk of acute respiratory failure (ARF) in hospitalised patients is limited. The aim of this study was to assess the risk of developing ARF in all hospitalised patients with vari ...
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Journal articleParkinsonism Relat Disord · October 2015
BACKGROUND: Uratic acid is a potent anti-oxidant and hyperuricemia is well-linked to a lower risk of Parkinson's disease (PD), one of the most common neurodegenerative disorders. However, data on gout, the major complication of hyperuricemia, remain unclea ...
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Journal articleNephrology (Carlton) · October 2015
AIM: The objective of this meta-analysis was to compare the effects of off-pump and on-pump coronary artery bypass grafting (CABG) on acute kidney injury (AKI) and the need of dialysis after surgery. METHODS: Comprehensive literature searches for randomize ...
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Journal articleSarcoidosis Vasc Diffuse Lung Dis · September 14, 2015
BACKGROUND: Several chronic inflammatory disorders, such as rheumatoid arthritis, inflammatory myositis and systemic lupus erythematosus, have been linked to an increased risk of venous thromboembolism (VTE). However, the data on sarcoidosis is unclear. OB ...
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Journal articleRen Fail · August 2015
BACKGROUND: The reported risk of hypomagnesemia in patients with proton pump inhibitor (PPI) use is conflicting. The objective of this meta-analysis was to assess the association between the use of PPIs and the risk of hypomagnesemia. METHODS: A literature ...
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Journal articleNephrol Dial Transplant · June 2015
BACKGROUND: Previous trials of interventions to prevent acute kidney injury (AKI) have been unsuccessful and additional interventions are needed. Existing reviews of preoperative renin-angiotensin system (RAS) inhibitors have suggested harm. We included mo ...
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Journal articleRen Fail · May 2015
BACKGROUND: The reports on the efficacy of statins for the prevention of contrast-induced acute kidney injury (CIAKI) remain controversial. The objective of this meta-analysis was to assess the effect of statins for the prevention of CIAKI. METHODS: Compre ...
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Journal articleIntern Med J · April 2015
BACKGROUND: The reported risk of depression in patients with hypomagnesaemia is controversial. AIM: The objective of this meta-analysis was to assess the association between depression and hypomagnesaemia. METHODS: A literature search was performed using M ...
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Journal articleRheumatology (Oxford) · April 2015
OBJECTIVE: The aim of this study was to integrate and examine the association between NSAID use and venous thromboembolism (VTE). METHODS: We conducted a systematic review and meta-analysis of studies that reported odds ratios, relative risks, hazard ratio ...
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Journal articleAnn Transl Med · March 2015
OBJECTIVE: To investigate the association between coronary artery disease (CAD) and ankylosing spondylitis (AS). METHODS: We conducted a systematic review and meta-analysis of observational studies that reported relative risks, hazard ratios, standardized ...
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Journal articleClin Exp Hypertens · 2015
BACKGROUND/OBJECTIVES: The risk of hypertension (HTN) in patients who regularly drink soda is controversial. The objective of this meta-analysis was to assess the associations between consumption of sugar and artificially sweetened soda and HTN. METHODS: A ...
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Journal articleClin Exp Rheumatol · 2015
OBJECTIVES: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to an increased risk of venous thromboembolism (VTE). However, the data on Sjögren's syndrome (SS) remain unclear. This stud ...
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Journal articleAm J Nephrol · 2015
BACKGROUND: The objective of this meta-analysis was to evaluate the risk of acute kidney injury (AKI) in patients who underwent transcatheter aortic valve replacement (TAVR). METHODS: A literature search was performed using MEDLINE, EMBASE, the Cochrane Da ...
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Journal articleRespirology · October 2014
A possible causal relationship between sarcoidosis and malignancy has been the subject of debates for decades. To better understand this association, we conducted a systematic review and meta-analysis of cohort studies that reported relative risk, hazard r ...
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Journal articleIndian J Crit Care Med · March 2014
Lemierre's syndrome is an uncommon, but fatal infection of the internal jugular vein (IJV) that is usually caused by Fusobacteirum necrophorum although a wide range of bacteria has been reported as causative agents. Typical symptoms include fever, sore thr ...
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Journal articleClin Rheumatol · March 2014
We performed this meta-analysis to assess venous thromboembolism risk in patients with rheumatoid arthritis. A comprehensive search was performed in MEDLINE, EMBASE, and the Cochrane databases. Nine observational studies met our inclusion criteria and were ...
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Journal articleJ Infect Chemother · October 2013
More than 90% of cases of pneumocystis pneumonia (PCP) in adults occur in patients with chronic HIV infection with CD4 counts lower than 200 cells/ml. Even though primary HIV infection can cause transient profound CD4 lymphocytopenia, PCP is rarely reporte ...
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Journal articleAm J Emerg Med · July 2013
Non-type B Haemophilus influenzae emerges as a new pathogen in the post H. influenzae serotype b vaccine era. We describe a case of polyarticular septic arthritis caused by H. influenzae serotype f in an adult. The patient was successfully treated with sur ...
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Journal articleAm J Emerg Med · April 2013
Denosumab, a human monoclonal antibody to the receptor activator of nuclear factor-κB ligand, is a novel therapy to osteoporotic fracture and skeletal-related events in patients with bone metastases. Hypocalcemia is its known adverse effect, although it is ...
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Journal articleAm J Emerg Med · February 2013
Acute monoarthritis is one of the most common rheumatologic presentations. However, it is clinically difficult to distinguish between an inflamed joint due to crystal-induced arthritis and an inflamed joint due to septic arthritis. Arthrocentesis and synov ...
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Journal articleAmerican Journal of Emergency Medicine · January 1, 2013
Non-type B Haemophilus influenzae emerges as a new pathogen in the post H. influenzae serotype b vaccine era. We describe a case of polyarticular septic arthritis caused by H. influenzae serotype f in an adult. The patient was successfully treated with sur ...
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Journal articleAm J Emerg Med · January 2013
Churg-Strauss syndrome (CSS) is a rare vasculitic disorder characterized by chronic rhinosinusitis, asthma, and persistent eosinophilia. Although not a usual prominent initial presentation, cardiac involvement is a major cause of morbidity and mortality in ...
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