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Negmeldeen Mamoun

Associate Professor of Anesthesiology
Anesthesiology, Cardiothoracic

Selected Publications


Reduce intraoperative albumin utilisation in cardiac surgical patients: a quality improvement initiative.

Journal Article BMJ Open Qual · April 24, 2024 BACKGROUND: Albumin continues to be used routinely by cardiac anaesthesiologists perioperatively despite lack of evidence for improved outcomes. The Multicenter Perioperative Outcomes Group (MPOG) data ranked our institution as one of the highest intraoper ... Full text Link to item Cite

Pain trajectories after bilateral orthotopic lung transplantation surgery performed via a clamshell incision.

Journal Article Clin Transplant · February 2024 INTRODUCTION: The nature, intensity, and progression of acute pain after bilateral orthotopic lung transplantation (BOLT) performed via a clamshell incision has not been well investigated. We aimed to describe acute pain after clamshell incisions using pai ... Full text Link to item Cite

Higher Cardiovagal Baroreflex Sensitivity Predicts Increased Pain Outcomes After Cardiothoracic Surgery.

Conference The journal of pain · January 2024 Excessive postoperative pain can lead to extended hospitalization and increased expenses, but factors that predict its severity are still unclear. Baroreceptor function could influence postoperative pain by modulating nociceptive processing and vagal-media ... Full text Cite

Higher Cardiovagal Baroreflex Sensitivity Predicts Increased Pain Outcomes After Cardiothoracic Surgery.

Conference J Pain · January 2024 Excessive postoperative pain can lead to extended hospitalization and increased expenses, but factors that predict its severity are still unclear. Baroreceptor function could influence postoperative pain by modulating nociceptive processing and vagal-media ... Full text Link to item Cite

Health care resource utilization and clinical outcomes for adult heart transplant recipients with primary graft dysfunction.

Journal Article Clin Transplant · October 2023 INTRODUCTION: The advent of new technologies to reduce primary graft dysfunction (PGD) and improve outcomes after heart transplantation are costly. Adoption of these technologies requires a better understanding of health care utilization, specifically the ... Full text Link to item Cite

Direct oral anticoagulants and their antagonists in perioperative practice.

Journal Article Curr Opin Anaesthesiol · August 1, 2023 PURPOSE OF REVIEW: Review management strategies for patients receiving nonvitamin K direct-acting oral anticoagulants (DOACs). RECENT FINDINGS: Updated clinical trials and guidelines continue to further define optimal management for patients on DOACs requi ... Full text Link to item Cite

Splanchnic Nerve Modulation Effects on Surrogate Measures of Venous Capacitance.

Journal Article J Am Heart Assoc · July 18, 2023 Background Splanchnic nerve modulation (SNM) is an emerging procedure to reduce cardiac filling pressures in heart failure. Although the main contributor to reduction in cardiac preload is thought to be increased venous capacitance in the splanchnic circul ... Full text Link to item Cite

Effectiveness of Simulation- Versus Didactic Video-Based Learning to Teach Advanced Lung Isolation Techniques.

Journal Article J Cardiothorac Vasc Anesth · May 2023 OBJECTIVES: Mastery of lung isolation is crucial for optimal cardiothoracic anesthesia education. The authors tested the hypothesis that simulation- is more effective than didactic video-based learning (cognitive, affective, and psychomotor) to teach anest ... Full text Link to item Cite

Pain Trajectories After Valve Surgeries Performed via Midline Sternotomy Versus Mini-Thoracotomy.

Journal Article J Cardiothorac Vasc Anesth · September 2022 OBJECTIVES: Controlling moderate-to-severe pain remains a major challenge after cardiothoracic surgery. Several outcomes have been compared extensively after valve surgery performed via midline sternotomy versus mini-thoracotomy, but postoperative pain (PO ... Full text Link to item Cite

Heated Humidified Breathing Circuit Rewarming in Hypothermic Patients Post-Cardiopulmonary Bypass-Pilot Study.

Journal Article J Cardiothorac Vasc Anesth · April 2022 OBJECTIVES: Hypothermia on intensive care unit (ICU) admission after cardiac surgery and cardiopulmonary bypass is common. It contributes to postoperative complications including shivering, coagulopathy, increased blood loss and transfusion requirements, m ... Full text Link to item Cite

Point-of-Care Ultrasound to Identify Landmarks of the Proximal Humerus: Potential Use for Intraosseous Vascular Access.

Journal Article J Ultrasound Med · April 2021 OBJECTIVES: The inability to identify landmarks is an absolute contraindication for intraosseous access. The feasibility of landmark identification using ultrasound (US) has been demonstrated on human cadavers. We aimed to study the feasibility of point-of ... Full text Link to item Cite

Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition.

Journal Article Compr Physiol · February 12, 2021 Baroreceptors are mechanosensitive elements of the peripheral nervous system that maintain cardiovascular homeostasis by coordinating the responses to external and internal environmental stressors. While it is well known that carotid and cardiopulmonary ba ... Full text Link to item Cite

Patient-Reported Chronic Pain Outcomes After Lung Transplantation.

Journal Article Semin Cardiothorac Vasc Anesth · March 2020 Chronic pain after lung transplantation is a significant concern, in particular given the heterogeneity of the patient population and the challenges of achieving adequate pain control amid concerns related to complex immunosuppressant regimens and the poss ... Full text Link to item Cite

Takotsubo cardiomyopathy complicating thoracoabdominal aortic aneurysm repair.

Journal Article J Clin Anesth · February 2018 We describe the management of a patient with symptomatic spinal cord hypoperfusion after thoracoabdominal aortic aneurysm repair, where the neurological insult and associated emotional stress precipitated Takotsubo cardiomyopathy. Transthoracic Echocardiog ... Full text Link to item Cite

Intravenous Acetaminophen Does Not Decrease Persistent Surgical Pain After Cardiac Surgery.

Journal Article J Cardiothorac Vasc Anesth · December 2017 OBJECTIVE: The authors investigated the hypothesis that perioperative acetaminophen reduces incisional pain at 30 and 90 days. DESIGN: This was a prospective, randomized, double-blind trial. SETTING: Tertiary-care hospital (single center) cardiac surgery u ... Full text Link to item Cite

Intravenous acetaminophen analgesia after cardiac surgery: A randomized, blinded, controlled superiority trial.

Journal Article J Thorac Cardiovasc Surg · September 2016 BACKGROUND: Pain after cardiac surgery traditionally has been controlled by intravenous opioids and nonsteroidal antiinflammatory drugs. An intravenous analgesic with fewer adverse effects is needed. Therefore, we tested the primary hypothesis that intrave ... Full text Link to item Cite

Reduce intraoperative albumin utilisation in cardiac surgical patients: a quality improvement initiative.

Journal Article BMJ Open Qual · April 24, 2024 BACKGROUND: Albumin continues to be used routinely by cardiac anaesthesiologists perioperatively despite lack of evidence for improved outcomes. The Multicenter Perioperative Outcomes Group (MPOG) data ranked our institution as one of the highest intraoper ... Full text Link to item Cite

Pain trajectories after bilateral orthotopic lung transplantation surgery performed via a clamshell incision.

Journal Article Clin Transplant · February 2024 INTRODUCTION: The nature, intensity, and progression of acute pain after bilateral orthotopic lung transplantation (BOLT) performed via a clamshell incision has not been well investigated. We aimed to describe acute pain after clamshell incisions using pai ... Full text Link to item Cite

Higher Cardiovagal Baroreflex Sensitivity Predicts Increased Pain Outcomes After Cardiothoracic Surgery.

Conference The journal of pain · January 2024 Excessive postoperative pain can lead to extended hospitalization and increased expenses, but factors that predict its severity are still unclear. Baroreceptor function could influence postoperative pain by modulating nociceptive processing and vagal-media ... Full text Cite

Higher Cardiovagal Baroreflex Sensitivity Predicts Increased Pain Outcomes After Cardiothoracic Surgery.

Conference J Pain · January 2024 Excessive postoperative pain can lead to extended hospitalization and increased expenses, but factors that predict its severity are still unclear. Baroreceptor function could influence postoperative pain by modulating nociceptive processing and vagal-media ... Full text Link to item Cite

Health care resource utilization and clinical outcomes for adult heart transplant recipients with primary graft dysfunction.

Journal Article Clin Transplant · October 2023 INTRODUCTION: The advent of new technologies to reduce primary graft dysfunction (PGD) and improve outcomes after heart transplantation are costly. Adoption of these technologies requires a better understanding of health care utilization, specifically the ... Full text Link to item Cite

Direct oral anticoagulants and their antagonists in perioperative practice.

Journal Article Curr Opin Anaesthesiol · August 1, 2023 PURPOSE OF REVIEW: Review management strategies for patients receiving nonvitamin K direct-acting oral anticoagulants (DOACs). RECENT FINDINGS: Updated clinical trials and guidelines continue to further define optimal management for patients on DOACs requi ... Full text Link to item Cite

Splanchnic Nerve Modulation Effects on Surrogate Measures of Venous Capacitance.

Journal Article J Am Heart Assoc · July 18, 2023 Background Splanchnic nerve modulation (SNM) is an emerging procedure to reduce cardiac filling pressures in heart failure. Although the main contributor to reduction in cardiac preload is thought to be increased venous capacitance in the splanchnic circul ... Full text Link to item Cite

Effectiveness of Simulation- Versus Didactic Video-Based Learning to Teach Advanced Lung Isolation Techniques.

Journal Article J Cardiothorac Vasc Anesth · May 2023 OBJECTIVES: Mastery of lung isolation is crucial for optimal cardiothoracic anesthesia education. The authors tested the hypothesis that simulation- is more effective than didactic video-based learning (cognitive, affective, and psychomotor) to teach anest ... Full text Link to item Cite

Pain Trajectories After Valve Surgeries Performed via Midline Sternotomy Versus Mini-Thoracotomy.

Journal Article J Cardiothorac Vasc Anesth · September 2022 OBJECTIVES: Controlling moderate-to-severe pain remains a major challenge after cardiothoracic surgery. Several outcomes have been compared extensively after valve surgery performed via midline sternotomy versus mini-thoracotomy, but postoperative pain (PO ... Full text Link to item Cite

Heated Humidified Breathing Circuit Rewarming in Hypothermic Patients Post-Cardiopulmonary Bypass-Pilot Study.

Journal Article J Cardiothorac Vasc Anesth · April 2022 OBJECTIVES: Hypothermia on intensive care unit (ICU) admission after cardiac surgery and cardiopulmonary bypass is common. It contributes to postoperative complications including shivering, coagulopathy, increased blood loss and transfusion requirements, m ... Full text Link to item Cite

Point-of-Care Ultrasound to Identify Landmarks of the Proximal Humerus: Potential Use for Intraosseous Vascular Access.

Journal Article J Ultrasound Med · April 2021 OBJECTIVES: The inability to identify landmarks is an absolute contraindication for intraosseous access. The feasibility of landmark identification using ultrasound (US) has been demonstrated on human cadavers. We aimed to study the feasibility of point-of ... Full text Link to item Cite

Baroreceptor Modulation of the Cardiovascular System, Pain, Consciousness, and Cognition.

Journal Article Compr Physiol · February 12, 2021 Baroreceptors are mechanosensitive elements of the peripheral nervous system that maintain cardiovascular homeostasis by coordinating the responses to external and internal environmental stressors. While it is well known that carotid and cardiopulmonary ba ... Full text Link to item Cite

Patient-Reported Chronic Pain Outcomes After Lung Transplantation.

Journal Article Semin Cardiothorac Vasc Anesth · March 2020 Chronic pain after lung transplantation is a significant concern, in particular given the heterogeneity of the patient population and the challenges of achieving adequate pain control amid concerns related to complex immunosuppressant regimens and the poss ... Full text Link to item Cite

Takotsubo cardiomyopathy complicating thoracoabdominal aortic aneurysm repair.

Journal Article J Clin Anesth · February 2018 We describe the management of a patient with symptomatic spinal cord hypoperfusion after thoracoabdominal aortic aneurysm repair, where the neurological insult and associated emotional stress precipitated Takotsubo cardiomyopathy. Transthoracic Echocardiog ... Full text Link to item Cite

Intravenous Acetaminophen Does Not Decrease Persistent Surgical Pain After Cardiac Surgery.

Journal Article J Cardiothorac Vasc Anesth · December 2017 OBJECTIVE: The authors investigated the hypothesis that perioperative acetaminophen reduces incisional pain at 30 and 90 days. DESIGN: This was a prospective, randomized, double-blind trial. SETTING: Tertiary-care hospital (single center) cardiac surgery u ... Full text Link to item Cite

Intravenous acetaminophen analgesia after cardiac surgery: A randomized, blinded, controlled superiority trial.

Journal Article J Thorac Cardiovasc Surg · September 2016 BACKGROUND: Pain after cardiac surgery traditionally has been controlled by intravenous opioids and nonsteroidal antiinflammatory drugs. An intravenous analgesic with fewer adverse effects is needed. Therefore, we tested the primary hypothesis that intrave ... Full text Link to item Cite

Eclamptic seizures

Chapter · January 1, 2011 Eclampsia is associated with increased risk of maternal and fetal morbidity and mortality. Aggressive attempts should be made to control seizures and hypertension. It usually develops after 20 weeks of gestation and just over one-third of cases occur at te ... Full text Cite

Propensity matched comparison of outcomes in older and younger patients after coronary artery bypass graft surgery.

Journal Article Ann Thorac Surg · June 2008 BACKGROUND: By 2050, the number of people in the United States aged 85 years and older is expected to increase from 4.2 to 20.8 million. We therefore compared outcomes after isolated coronary artery bypass grafting (CABG) in patients aged 85 years and olde ... Full text Link to item Cite