Neil J. Freedman

Professor of Medicine

Medicine, Cardiology

neil.freedman@duke.edu

Duke Box 102150, Durham, NC 27710

447 Clin & Res Labs, Box 102150 Duke University Medical Ctr, Durham, NC 27710

More About This Person

At a Glance

Credentials
1. Education

Academic Experience

Global Scholarship

Keywords

Research
1. Selected Grants
2. External Relationships

Scholarly Works

Teaching & Mentoring
1. Recent Courses

Recognition

Professional Activities

Scholarly Works - Conferences

Angiotensin II-Induced Aortic Inflammation and Remodeling Are Mitigated by the Actin-Binding Protein Drebrin

Conference CIRCULATION · November 14, 2017 Link to item Cite

The Atherosclerosis Candidate Gene Product Kalirin Reduces Atherosclerosis via Macrophage-Specific Mechanisms

Conference CIRCULATION · November 14, 2017 Link to item Cite

Ubiquitin-Specific Protease 20 Attenuates Atherosclerosis through Activity in Smooth Muscle Cells

Conference CIRCULATION · November 11, 2016 Link to item Cite

The Dual RhoGEF Kalirin Reduces Atherosclerosis Through Endothelial Cell-Specific Mechanisms

Conference CIRCULATION · November 26, 2013 Link to item Cite

Immunoglobulin-Like Domain Containing Receptor Mediates Fat-Stimulated Cholecystokinin Secretion

Conference GASTROENTEROLOGY · May 1, 2013 Link to item Cite

The Actin-Binding Protein Drebrin Reduces TRP Channel Activity and Neointimal Hyperplasia

Conference CIRCULATION · November 20, 2012 Link to item Cite

The Dual Rho-GEF Kalirin Promotes Atherosclerosis by Augmenting Smooth Muscle Cell Rac1 Signaling, Migration, and Proliferation

Conference CIRCULATION · November 23, 2010 Link to item Cite

Arterial Wall Expression of Tumor Necrosis Factor Receptor-2 Attenuates Atherosclerosis by Reducing Recruitment of Monocyte/Macrophages

Conference CIRCULATION · November 3, 2009 Link to item Cite

The Dual Rho-GEF Kalirin Promotes Vascular Smooth Muscle Cell Migration and Proliferation

Conference CIRCULATION · November 3, 2009 Link to item Cite

G Protein-coupled Receptor Kinase-5 Attenuates Atherosclerosis by Reducing PDGF-induced Smooth Muscle Cell Proliferation and Migration

Conference CIRCULATION · November 3, 2009 Link to item Cite

Tumor Necrosis Factor Receptor-1 Aggravates Aging-Associated Atherosclerosis

Conference CIRCULATION · October 28, 2008 Link to item Cite

CXCR4 Signaling Exacerbates Vein Graft Neointimal Hyperplasia

Conference CIRCULATION · October 28, 2008 Link to item Cite

Molecular Mechanisms for Reciprocal Regulation of the PDGF Receptor and G Protein-coupled Receptor Kinase-5

Conference FASEB JOURNAL · April 1, 2008 Link to item Cite

Aging of the arterial wall exacerbates atherosclerosis

Conference CIRCULATION · October 16, 2007 Link to item Cite

Human cord blood endothelial progenitors decrease neointimal hyperplasia in SCID mouse vein grafts

Conference JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 6, 2007 Link to item Cite

Vein graft thrombosis and neointimal hyperplasia can be potentiated by angiopoeitins-1 and-2

Conference CIRCULATION · October 31, 2006 Link to item Cite

Arterial wall TNF receptor-1 expression accelerates atherosclerosis by enhancing neointimal cell recruitment

Conference CIRCULATION · October 31, 2006 Link to item Cite

beta-arrestins regulate proliferation and migration of smooth muscle cells in vitro & in vivo: Isoform-specific roles

Conference CIRCULATION · October 31, 2006 Link to item Cite

Tumor necrosis factor receptor-2 signaling attenuates vein graft neointimal hyperplasia and medial hypertrophy

Conference CIRCULATION · October 25, 2005 Link to item Cite

Regulation of the smooth muscle cell platelet-derived growth factor peptidyl prolyl isomerase receptor-beta by G protein-coupled receptor kinase-5 involves the phosphatase Shp2

Conference CIRCULATION · October 25, 2005 Link to item Cite

The platelet-derived growth factor receptor-beta triggers its own desensitization by tyrosine-phosphorylating G protein-coupled receptor kinase-2

Conference CIRCULATION · October 25, 2005 Link to item Cite

Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinases in smooth muscle cells and fibroblasts: Evidence for kinase specificity

Conference CIRCULATION · October 26, 2004 Link to item Cite

The platelet-derived growth factor receptor beta-tyrosine phosphorylates G protein-coupled receptor kinase-2: Mechanism for feedback inhibition

Conference CIRCULATION · October 26, 2004 Link to item Cite

TNF-receptor-1 signaling in graft-intrinsic cells regulates vein graft neointima formation and VCAM-1 expression

Conference CIRCULATION · October 26, 2004 Link to item Cite

G protein-coupled receptor kinase-2 and -3: tightly regulated substrate specificities at cardiac myocyte receptors provide basis for distinct roles in regulation of myocardial function

Conference EUROPEAN HEART JOURNAL · August 1, 2004 Link to item Cite

Tumor necrosis factor receptor-1 signaling regulates vein graft arterialization

Conference CIRCULATION · October 28, 2003 Link to item Cite

Arterial wall expression of the tumor necrosis factor receptor-1 contributes to the pathogenesis of atherosclerosis

Conference CIRCULATION · October 28, 2003 Link to item Cite

A novel murine vein graft model reveals the mixed origin of neointimal cells

Conference CIRCULATION · November 5, 2002 Link to item Cite

G protein-coupled receptor kinase-2 phosphorylates and selectively desensitizes receptor tyrosine kinases

Conference CIRCULATION · November 5, 2002 Link to item Cite

The adaptor protein beta-Arrestin2 enhances endocytosis of the low-density lipoprotein receptor

Conference CIRCULATION · November 5, 2002 Link to item Cite

PDGF receptor phosphorylation and desensitization by G protein-coupled receptor kinase-2

Conference CIRCULATION · October 23, 2001 Link to item Cite

TNF involvement in the development of neointimal hyperplasia

Conference CIRCULATION · October 23, 2001 Link to item Cite

PDGF receptor desensitization by G protein-coupled receptor kinase-2

Conference CIRCULATION · October 31, 2000 Link to item Cite

Receptor kinase overexpression reduces neointimal hyperplasia

Conference CIRCULATION · November 2, 1999 Link to item Cite

G protein-coupled receptor kinases attenuate smooth muscle cell mitogenesis and chemotaxis

Conference CIRCULATION · November 2, 1999 Link to item Cite

TNF-inhibitor gene therapy for neointimal hyperplasia

Conference CIRCULATION · November 2, 1999 Link to item Cite

Receptor kinase gene therapy for neointimal hyperplasia

Conference CIRCULATION · October 27, 1998 Link to item Cite

TOPICAL BETA-BLOCKERS AND PLASMA-LIPIDS - CARTEOLOL VS TIMOLOL

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 1993 Link to item Cite