Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Hematology-Oncology Fellowship, Medicine, Duke University School of Medicine 2015 - 2018
  • Internal Medicine Internship and Residency, Tufts University School of Medicine 2012 - 2015
  • M.D., University of South Florida, College of Medicine 2012
• Research
• 

  Selected Grants

  • Investigating the Role of EMT-mediated Dendritic Cell Tolerization in Checkpoint Inhibitor Resistance awarded by Damon Runyon Cancer Research Foundation 2018 - 2022
  • Investigating Oncogenic Signaling Pathways that Drive Wnt Ligand-mediated Immune Tolerance in Melanoma awarded by Conquer Cancer Foundation 2017 - 2018
• 

  External Relationships

  • Quality Fieldwork Associates
  • The Dedham Group LLC
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Plebanek, Michael P., Michael Sturdivant, Nicholas C. DeVito, and Brent A. Hanks. “Role of dendritic cell metabolic reprogramming in tumor immune evasion.” Int Immunol 32, no. 7 (June 26, 2020): 485–91. https://doi.org/10.1093/intimm/dxaa036.
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    • Theivanthiran, Balamayoora, Kathy S. Evans, Nicholas C. DeVito, Michael Plebanek, Michael Sturdivant, Luke P. Wachsmuth, April Ks Salama, et al. “A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy.” J Clin Invest 130, no. 5 (May 1, 2020): 2570–86. https://doi.org/10.1172/JCI133055.
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    • DeVito, Nicholas C., Michael P. Plebanek, Bala Theivanthiran, and Brent A. Hanks. “Role of Tumor-Mediated Dendritic Cell Tolerization in Immune Evasion.” Front Immunol 10 (2019): 2876. https://doi.org/10.3389/fimmu.2019.02876.
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    • Grant, Michael J., Nicholas DeVito, and April K. S. Salama. “Checkpoint inhibitor use in two heart transplant patients with metastatic melanoma and review of high-risk populations.” Melanoma Manag 5, no. 4 (December 2018): MMT10. https://doi.org/10.2217/mmt-2018-0004.
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    • Zhao, Fei, Kathy Evans, Christine Xiao, Nicholas DeVito, Balamayooran Theivanthiran, Alisha Holtzhausen, Peter J. Siska, Gerard C. Blobe, and Brent A. Hanks. “Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma.” Cancer Immunol Res 6, no. 12 (December 2018): 1459–71. https://doi.org/10.1158/2326-6066.CIR-18-0086.
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    • Zhao, Fei, Christine Xiao, Kathy S. Evans, Tbalamayooran Theivanthiran, Nicholas DeVito, Alisha Holtzhausen, Juan Liu, et al. “Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.” Immunity 48, no. 1 (January 16, 2018): 147-160.e7. https://doi.org/10.1016/j.immuni.2017.12.004.
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    • Kinsey, E. N., N. DeVito, W. Barrow, S. A. Myers, and A. K. S. Salama. “Paraneoplastic Production of Granulocyte-macrophage Colony-stimulating Factor and Granulocyte Colony-stimulating Factor in a Case of Rapidly Progressing Cutaneous Squamous Cell Carcinoma.” Clinical Skin Cancer 1, no. 1 (January 1, 2016): 20–22. https://doi.org/10.1016/j.clsc.2016.11.004.
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    • DeVito, Nicholas, Evita Henderson, Gang Han, Damon Reed, Marilyn M. Bui, Robert Lavey, Lary Robinson, et al. “Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience.” Plos One 10, no. 10 (2015): e0140362. https://doi.org/10.1371/journal.pone.0140362.
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    • DeVito, Nicholas, Kit Mui, Yasir Jassam, Lynne Taylor, Monika Pilichowska, and Furha Cossor. “Small lymphocytic lymphoma presenting as a paraneoplastic syndrome with acute central nervous system demyelination.” Clin Lymphoma Myeloma Leuk 14, no. 4 (August 2014): e131–35. https://doi.org/10.1016/j.clml.2014.02.006.
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    • DeVito, Nicholas C., and Muhammad Wasif Saif. “Advances in immunotherapy for pancreatic cancer: 2013.” Jop 14, no. 4 (July 10, 2013): 347–53. https://doi.org/10.6092/1590-8577/1646.
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    • Devito, Nicholas, Michael Yu, Ren Chen, and Edward Pan. “Retrospective study of patients with brain metastases from melanoma receiving concurrent whole-brain radiation and temozolomide.” Anticancer Res 31, no. 12 (December 2011): 4537–43.
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    • Assudani, Deepak, Hyun-Il Cho, Nicholas DeVito, Norma Bradley, and Esteban Celis. “In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells.” Cancer Res 68, no. 23 (December 1, 2008): 9892–99. https://doi.org/10.1158/0008-5472.CAN-08-3134.
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  • Conference Papers

    • DeVito, Nicholas, Michael Sturdivant, Luke Wachsmuth, John Strickler, Georgia Beasley, Rami Al-Rohil, April Salama, and Brent Hanks. “425 Investigation of Wnt ligand signaling regulators as a predictor of Anti-PD-1 response in metastatic melanoma.” In Journal for Immunotherapy of Cancer, 8:A450–A450. BMJ, 2020. https://doi.org/10.1136/jitc-2020-sitc2020.0425.
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    • Theivanthiran, Balamayooran, Kathy Evans, Nicholas DeVito, Michael Plebanek, Michael Sturdivant, Alisha Holtzhausen, Luke Wachsmuth, et al. “A tumor PD-L1-NLRP3 inflammasome signaling axis drives adaptive resistance to anti-PD-1 immunotherapy.” In Journal for Immunotherapy of Cancer, Vol. 7. BMC, 2019.
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    • Theivanthiran, Bala, Nicholas C. DeVito, Kathy Evans, Fei Zhao, Christine Xiao, Benjamin S. Goldschmidt, Rob Edgar, et al. “A HSP-TLR-Wnt5a paracrine signaling axis drives CXCR2 ligand recruitment of myeloid-derived suppressor cells and represents a novel adaptive resistance mechanism to anti-PD-1 antibody therapy.” In Journal for Immunotherapy of Cancer, Vol. 5. BMC, 2017.
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    • DeVito, Nicholas. “LITTLE KNOWN LYMPHOMA: SMALL LYMPHOCYTIC LYMPHOMA PRESENTING AS A PARANEOPLASTIC SYNDROME WITH ACUTE CNS DEMYELINATION.” In Journal of General Internal Medicine, 29:S384–S384. SPRINGER, 2014.
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    • Thievanthiran, Bala, Nicholas DeVito, Kathy Evans, and B. A. Hanks. “Inflammasome-Wnt Ligand Signaling Axis Promotes Immune Escape During Anti-PD-1 Antibody Immunotherapy.” In Journal for Immunotherapy of Cancer. BioMed Central, n.d.
• Scholarly, Clinical, & Service Activities
• 

  Presentations & Appearances

  • Updates in the Management of Resected Pancreatic Cancer. Duke Cancer Review. Duke Cancer Network. July 2019  2019
  • The Role of Immunotherapy in the Treatment of Advanced Gastroesophageal Cancers. Duke Cancer Network. February 2019  2019
• 

  Academic & Administrative Activities

  • In addition to my research and clinical duties, I conduct fellowship interviews, teach residents and fellows during clinic and while on the 9300 inpatient medical oncology service, and give educational talks to fellows in both oncology and palliative care. I also participate in a directed mentoring program for aspiring laboratory and translational-based hematology/oncology fellows.
• 

  Clinical Activities

  • I have a weekly clinic in medical oncology focused on gastrointestinal malignancies. I also attend the 9300 inpatient medical oncology service.

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