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Nicholas Christian DeVito

Assistant Professor of Medicine
Medicine, Medical Oncology
DUMC Box 3052, Durham, NC 27710
308 Research Drive, Levine Science Research, C161, Durham, NC 27710

Overview


I am an Assistant Professor of Medical Oncology who primarily treats patients with colon cancer and gastroesophageal cancers, where I also conduct early phase immunotherapeutic trials. My laboratory and translational research are focused on tumor immune evasion and immunotherapy, particularly in the setting of metastasis. This work has led to a specific interest in tumor-mediated development of dendritic cell tolerance and suppressive myeloid populations. The ultimate goal of these studies is to create biomarker-directed immunotherapies for advanced gastrointestinal cancers.

Current Appointments & Affiliations


Assistant Professor of Medicine · 2023 - Present Medicine, Medical Oncology, Medicine
Member of the Duke Cancer Institute · 2018 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published January 20, 2026
Over-the-Counter Drugs Influence Cancer Immunotherapy
Published April 21, 2025
The Steps That Crushed Colorectal Cancer

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Recent Publications


Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Suppressing MHC Class I Expression.

Journal Article medRxiv · October 7, 2025 Immunotherapy resistance remains a major challenge in immuno-oncology. We have previously demonstrated that a tumor-intrinsic NLRP3 inflammasome signaling pathway promotes adaptive immunotherapy resistance by inducing the recruitment of granulocytic myeloi ... Full text Link to item Cite
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Education


University of South Florida, College of Medicine · 2012 M.D.