Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Hematology-Oncology Fellowship, Medicine, Duke University School of Medicine 2015 - 2018
  • Internal Medicine Internship and Residency, Tufts University School of Medicine 2012 - 2015
  • M.D., University of South Florida, College of Medicine 2012
• Research
• 

  Selected Grants

  • Investigating the Role of EMT-mediated Dendritic Cell Tolerization in Checkpoint Inhibitor Resistance awarded by Damon Runyon Cancer Research Foundation 2018 - 2022
  • Investigating Oncogenic Signaling Pathways that Drive Wnt Ligand-mediated Immune Tolerance in Melanoma awarded by Conquer Cancer Foundation 2017 - 2018
• 

  External Relationships

  • Quality Fieldwork Associates
  • The Dedham Group LLC
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Plebanek, Michael P., Michael Sturdivant, Nicholas C. DeVito, and Brent A. Hanks. “Role of dendritic cell metabolic reprogramming in tumor immune evasion.” Int Immunol 32, no. 7 (June 26, 2020): 485–91. https://doi.org/10.1093/intimm/dxaa036.
       Full Text  Link to Item
    • Theivanthiran, Balamayoora, Kathy S. Evans, Nicholas C. DeVito, Michael Plebanek, Michael Sturdivant, Luke P. Wachsmuth, April Ks Salama, et al. “A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy.” J Clin Invest 130, no. 5 (May 1, 2020): 2570–86. https://doi.org/10.1172/JCI133055.
       Full Text  Link to Item
    • DeVito, Nicholas C., Michael P. Plebanek, Bala Theivanthiran, and Brent A. Hanks. “Role of Tumor-Mediated Dendritic Cell Tolerization in Immune Evasion.” Front Immunol 10 (2019): 2876. https://doi.org/10.3389/fimmu.2019.02876.
       Full Text  Link to Item
    • Grant, Michael J., Nicholas DeVito, and April K. S. Salama. “Checkpoint inhibitor use in two heart transplant patients with metastatic melanoma and review of high-risk populations.” Melanoma Manag 5, no. 4 (December 2018): MMT10. https://doi.org/10.2217/mmt-2018-0004.
       Full Text  Link to Item
    • Zhao, Fei, Kathy Evans, Christine Xiao, Nicholas DeVito, Balamayooran Theivanthiran, Alisha Holtzhausen, Peter J. Siska, Gerard C. Blobe, and Brent A. Hanks. “Stromal Fibroblasts Mediate Anti-PD-1 Resistance via MMP-9 and Dictate TGFβ Inhibitor Sequencing in Melanoma.” Cancer Immunol Res 6, no. 12 (December 2018): 1459–71. https://doi.org/10.1158/2326-6066.CIR-18-0086.
       Full Text  Open Access Copy  Link to Item
    • Zhao, Fei, Christine Xiao, Kathy S. Evans, Tbalamayooran Theivanthiran, Nicholas DeVito, Alisha Holtzhausen, Juan Liu, et al. “Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization.” Immunity 48, no. 1 (January 16, 2018): 147-160.e7. https://doi.org/10.1016/j.immuni.2017.12.004.
       Full Text  Open Access Copy  Link to Item
    • Kinsey, E. N., N. DeVito, W. Barrow, S. A. Myers, and A. K. S. Salama. “Paraneoplastic Production of Granulocyte-macrophage Colony-stimulating Factor and Granulocyte Colony-stimulating Factor in a Case of Rapidly Progressing Cutaneous Squamous Cell Carcinoma.” Clinical Skin Cancer 1, no. 1 (January 1, 2016): 20–22. https://doi.org/10.1016/j.clsc.2016.11.004.
       Full Text
    • DeVito, Nicholas, Evita Henderson, Gang Han, Damon Reed, Marilyn M. Bui, Robert Lavey, Lary Robinson, et al. “Clinical Characteristics and Outcomes for Solitary Fibrous Tumor (SFT): A Single Center Experience.” Plos One 10, no. 10 (2015): e0140362. https://doi.org/10.1371/journal.pone.0140362.
       Full Text  Link to Item
    • DeVito, Nicholas, Kit Mui, Yasir Jassam, Lynne Taylor, Monika Pilichowska, and Furha Cossor. “Small lymphocytic lymphoma presenting as a paraneoplastic syndrome with acute central nervous system demyelination.” Clin Lymphoma Myeloma Leuk 14, no. 4 (August 2014): e131–35. https://doi.org/10.1016/j.clml.2014.02.006.
       Full Text  Link to Item
    • DeVito, Nicholas C., and Muhammad Wasif Saif. “Advances in immunotherapy for pancreatic cancer: 2013.” Jop 14, no. 4 (July 10, 2013): 347–53. https://doi.org/10.6092/1590-8577/1646.
       Full Text  Link to Item
    • Devito, Nicholas, Michael Yu, Ren Chen, and Edward Pan. “Retrospective study of patients with brain metastases from melanoma receiving concurrent whole-brain radiation and temozolomide.” Anticancer Res 31, no. 12 (December 2011): 4537–43.
       Link to Item
    • Assudani, Deepak, Hyun-Il Cho, Nicholas DeVito, Norma Bradley, and Esteban Celis. “In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells.” Cancer Res 68, no. 23 (December 1, 2008): 9892–99. https://doi.org/10.1158/0008-5472.CAN-08-3134.
       Full Text  Link to Item

  • Conference Papers

    • Theivanthiran, Balamayooran, Kathy Evans, Nicholas DeVito, Michael Plebanek, Michael Sturdivant, Alisha Holtzhausen, Luke Wachsmuth, et al. “A tumor PD-L1-NLRP3 inflammasome signaling axis drives adaptive resistance to anti-PD-1 immunotherapy.” In Journal for Immunotherapy of Cancer, Vol. 7. BMC, 2019.
       Link to Item
    • Theivanthiran, Bala, Nicholas C. DeVito, Kathy Evans, Fei Zhao, Christine Xiao, Benjamin S. Goldschmidt, Rob Edgar, et al. “A HSP-TLR-Wnt5a paracrine signaling axis drives CXCR2 ligand recruitment of myeloid-derived suppressor cells and represents a novel adaptive resistance mechanism to anti-PD-1 antibody therapy.” In Journal for Immunotherapy of Cancer, Vol. 5. BMC, 2017.
       Link to Item
    • DeVito, Nicholas. “LITTLE KNOWN LYMPHOMA: SMALL LYMPHOCYTIC LYMPHOMA PRESENTING AS A PARANEOPLASTIC SYNDROME WITH ACUTE CNS DEMYELINATION.” In Journal of General Internal Medicine, 29:S384–S384. SPRINGER, 2014.
       Link to Item
    • Thievanthiran, Bala, Nicholas DeVito, Kathy Evans, and B. A. Hanks. “Inflammasome-Wnt Ligand Signaling Axis Promotes Immune Escape During Anti-PD-1 Antibody Immunotherapy.” In Journal for Immunotherapy of Cancer. BioMed Central, n.d.
• Scholarly, Clinical, & Service Activities
• 

  Presentations & Appearances

  • Updates in the Management of Resected Pancreatic Cancer. Duke Cancer Review. Duke Cancer Network. July 2019  2019
  • The Role of Immunotherapy in the Treatment of Advanced Gastroesophageal Cancers. Duke Cancer Network. February 2019  2019
• 

  Academic & Administrative Activities

  • In addition to my research and clinical duties, I conduct fellowship interviews, teach residents and fellows during clinic and while on the 9300 inpatient medical oncology service, and give educational talks to fellows in both oncology and palliative care. I also participate in a directed mentoring program for aspiring laboratory and translational-based hematology/oncology fellows.
• 

  Clinical Activities

  • I have a weekly clinic in medical oncology focused on gastrointestinal malignancies. I also attend the 9300 inpatient medical oncology service.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.