Nicholas Scott Heaton
Assistant Professor of Molecular Genetics and Microbiology
Current Appointments & Affiliations
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2015
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., University of Chicago 2012
- Recognition
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In the News
- Research
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Selected Grants
- Loss of cellular identity after influenza virus infection and effects on pulmonary function awarded by National Institutes of Health 2018 - 2023
- The pathogenic effects of epithelial cells surviving direct influenza virus infection awarded by National Institutes of Health 2019 - 2023
- Targeting virally induced inflammation to prevent the development of asthma awarded by Hartwell Foundation 2018 - 2021
- Antigenically stabilized H3N2 vaccines that avoid egg adaption awarded by University of Rochester Medical Center 2018 - 2020
- Hemagglutinin proteins with non-immunogenic head domains as a universal influenza virus vaccine awarded by University of Rochester Medical Center 2018 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- The effects of cells that survive direct influenza A virus infection on lung repair awarded by National Institutes of Health 2017 - 2019
- Effect of m6A editing of RNA on influenza A virus replication awarded by National Institutes of Health 2017 - 2018
- Survival of influenza A virus infected cells and effects on pathogenesis awarded by National Institutes of Health 2015 - 2017
- Publications & Artistic Works
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Selected Publications
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Academic Articles
- Dumm, RE, Fiege, JK, Waring, BM, Kuo, CT, Langlois, RA, and Heaton, NS. "Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function." Nature Communications 10, no. 1 (February 15, 2019): 779-null. Full Text
- Fulton, BO, Sun, W, Heaton, NS, and Palese, P. "The Influenza B Virus Hemagglutinin Head Domain Is Less Tolerant to Transposon Mutagenesis than That of the Influenza A Virus." Journal of Virology 92, no. 16 (August 2018). Full Text
- Harding, AT, and Heaton, NS. "Efforts to Improve the Seasonal Influenza Vaccine." Vaccines 6, no. 2 (March 30, 2018). (Review) Full Text
- Heaton, NS, and Cullen, BR. "INFECTION Viruses hijack a long non-coding RNA." NATURE 552, no. 7684 (December 14, 2017): 184-185. Link to Item
- Courtney, DG, Kennedy, EM, Dumm, RE, Bogerd, HP, Tsai, K, Heaton, NS, and Cullen, BR. "Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication." Cell Host & Microbe 22, no. 3 (September 2017): 377-386.e5. Full Text
- Heaton, BE, Kennedy, EM, Dumm, RE, Harding, AT, Sacco, MT, Sachs, D, and Heaton, NS. "A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor." Cell Reports 20, no. 7 (August 2017): 1503-1512. Full Text
- Heaton, NS. "Revisiting the concept of a cytopathic viral infection." PLoS pathogens 13, no. 7 (July 20, 2017): e1006409-. (Review) Full Text
- Harding, AT, Heaton, BE, Dumm, RE, and Heaton, NS. "Rationally Designed Influenza Virus Vaccines That Are Antigenically Stable during Growth in Eggs." Mbio 8, no. 3 (June 6, 2017). Full Text
- Hamilton, JR, Sachs, D, Lim, JK, Langlois, RA, Palese, P, and Heaton, NS. "Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity." Proceedings of the National Academy of Sciences of the United States of America 113, no. 14 (April 2016): 3861-3866. Full Text
- Heaton, NS, Moshkina, N, Fenouil, R, Gardner, TJ, Aguirre, S, Shah, PS, Zhao, N, Manganaro, L, Hultquist, JF, Noel, J, Sachs, D, Hamilton, J, Leon, PE, Chawdury, A, Tripathi, S, Melegari, C, Campisi, L, Hai, R, Metreveli, G, Gamarnik, AV, García-Sastre, A, Greenbaum, B, Simon, V, Fernandez-Sesma, A, Krogan, NJ, Mulder, LCF, van Bakel, H, Tortorella, D, Taunton, J, Palese, P, and Marazzi, I. "Corrections to Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. (Immunity 44, 46-58, January 19, 2016)." Immunity 44, no. 2 (February 16, 2016): 438-null. Full Text
- Heaton, NS, Moshkina, N, Fenouil, R, Gardner, TJ, Aguirre, S, Shah, PS, Zhao, N, Manganaro, L, Hultquist, JF, Noel, J, Sachs, D, Hamilton, J, Leon, PE, Chawdury, A, Tripathi, S, Melegari, C, Campisi, L, Hai, R, Metreveli, G, Gamarnik, AV, García-Sastre, A, Greenbaum, B, Simon, V, Fernandez-Sesma, A, Krogan, NJ, Mulder, LCF, van Bakel, H, Tortorella, D, Taunton, J, Palese, P, and Marazzi, I. "Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection." Immunity 44, no. 1 (January 2016): 46-58. Full Text
- Fulton, BO, Palese, P, and Heaton, NS. "Replication-Competent Influenza B Reporter Viruses as Tools for Screening Antivirals and Antibodies." Journal of Virology 89, no. 23 (December 2015): 12226-12231. Full Text
- Fulton, BO, Sachs, D, Beaty, SM, Won, ST, Lee, B, Palese, P, and Heaton, NS. "Mutational Analysis of Measles Virus Suggests Constraints on Antigenic Variation of the Glycoproteins." Cell Reports 11, no. 9 (June 2015): 1331-1338. Full Text
- Heaton, NS, Langlois, RA, Sachs, D, Lim, JK, Palese, P, and tenOever, BR. "Long-term survival of influenza virus infected club cells drives immunopathology." The Journal of experimental medicine 211, no. 9 (August 18, 2014): 1707-1714. Full Text
- Dolan, PT, Zhang, C, Khadka, S, Arumugaswami, V, Vangeloff, AD, Heaton, NS, Sahasrabudhe, S, Randall, G, Sun, R, and LaCount, DJ. "Identification and comparative analysis of hepatitis C virus-host cell protein interactions." Molecular Biosystems 9, no. 12 (December 2013): 3199-3209. Full Text
- Heaton, NS, Sachs, D, Chen, C-J, Hai, R, and Palese, P. "Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins." Proceedings of the National Academy of Sciences of the United States of America 110, no. 50 (December 2013): 20248-20253. Full Text
- Margine, I, Krammer, F, Hai, R, Heaton, NS, Tan, GS, Andrews, SA, Runstadler, JA, Wilson, PC, Albrecht, RA, García-Sastre, A, and Palese, P. "Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses." Journal of Virology 87, no. 19 (October 2013): 10435-10446. Full Text
- Heaton, NS, Leyva-Grado, VH, Tan, GS, Eggink, D, Hai, R, and Palese, P. "In vivo bioluminescent imaging of influenza a virus infection and characterization of novel cross-protective monoclonal antibodies." Journal of Virology 87, no. 15 (August 2013): 8272-8281. Full Text
- Chou, Y-Y, Heaton, NS, Gao, Q, Palese, P, Singer, RH, and Lionnet, T. "Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis." Plos Pathogens 9, no. 5 (January 2013): e1003358-null. Full Text
- Chukkapalli, V, Heaton, NS, and Randall, G. "Lipids at the interface of virus-host interactions." Current Opinion in Microbiology 15, no. 4 (August 2012): 512-518. (Review) Full Text
- Coller, KE, Heaton, NS, Berger, KL, Cooper, JD, Saunders, JL, and Randall, G. "Molecular determinants and dynamics of hepatitis C virus secretion." Plos Pathogens 8, no. 1 (January 5, 2012): e1002466-null. Full Text
- Khadka, S, Vangeloff, AD, Zhang, C, Siddavatam, P, Heaton, NS, Wang, L, Sengupta, R, Sahasrabudhe, S, Randall, G, Gribskov, M, Kuhn, RJ, Perera, R, and LaCount, DJ. "A physical interaction network of dengue virus and human proteins." Molecular and Cellular Proteomics 10, no. 12 (December 1, 2011). Full Text
- Khadka, S, Vangeloff, AD, Zhang, C, Siddavatam, P, Heaton, NS, Wang, L, Sengupta, R, Sahasrabudhe, S, Randall, G, Gribskov, M, Kuhn, RJ, Perera, R, and LaCount, DJ. "A physical interaction network of dengue virus and human proteins." Molecular & Cellular Proteomics : Mcp 10, no. 12 (December 2011): M111.012187-null. Full Text
- Heaton, NS, and Randall, G. "Dengue virus and autophagy." Viruses 3, no. 8 (August 4, 2011): 1332-1341. (Review) Full Text
- Heaton, NS, and Randall, G. "Multifaceted roles for lipids in viral infection." Trends in microbiology 19, no. 7 (July 2011): 368-375. (Review) Full Text
- Khadka, S, Vangeloff, AD, Zhang, C, Siddavatam, P, Heaton, NS, Wang, L, Sengupta, R, Sahasrabudhe, S, Randall, G, Gribskov, M, Kuhn, RJ, Perera, R, and LaCount, DJ. "A physical interaction network of dengue virus and human proteins." Molecular & cellular proteomics : MCP 10, no. 12 (2011): M111.012187-. Full Text
- Heaton, NS, and Randall, G. "Dengue virus-induced autophagy regulates lipid metabolism." Cell Host & Microbe 8, no. 5 (November 2010): 422-432. Full Text
- Heaton, NS, Perera, R, Berger, KL, Khadka, S, Lacount, DJ, Kuhn, RJ, and Randall, G. "Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis." Proceedings of the National Academy of Sciences of the United States of America 107, no. 40 (October 2010): 17345-17350. Full Text
- Coller, KE, Berger, KL, Heaton, NS, Cooper, JD, Yoon, R, and Randall, G. "RNA interference and single particle tracking analysis of hepatitis C virus endocytosis." Plos Pathogens 5, no. 12 (December 24, 2009): e1000702-null. Full Text
- Berger, KL, Cooper, JD, Heaton, NS, Yoon, R, Oakland, TE, Jordan, TX, Mateu, G, Grakoui, A, and Randall, G. "Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication." Proceedings of the National Academy of Sciences of the United States of America 106, no. 18 (May 2009): 7577-7582. Full Text
- Heaton, NS, Wolff, RA, Malinowski, RL, Hullett, DA, and Hoch, JR. "Antisense to transforming growth factor-beta(1) facilitates the apoptosis of macrophages in rat vein grafts." Journal of vascular research 45, no. 5 (January 2008): 365-374. Full Text
- Wolff, RA, Malinowski, RL, Heaton, NS, Hullett, DA, and Hoch, JR. "Transforming growth factor-beta1 antisense treatment of rat vein grafts reduces the accumulation of collagen and increases the accumulation of h-caldesmon." Journal of vascular surgery 43, no. 5 (May 2006): 1028-1036. Full Text
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- Teaching & Mentoring
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Recent Courses
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