Overview
Our research group is primarily interested in the study of respiratory RNA viruses. We have published work on viruses of the families: orthomyxoviridae, paramyxoviridae, and coronaviridae. The research in our laboratory is predominantly focused understanding the mechanisms of viral pathogenesis with the ultimate goal of developing new therapies that can be used to combat both current and future viral diseases.
Current Appointments & Affiliations
Associate Professor of Molecular Genetics and Microbiology
·
2022 - Present
Molecular Genetics and Microbiology,
Basic Science Departments
Associate Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Associate Professor in Integrative Immunobiology
·
2024 - Present
Integrative Immunobiology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2017 - Present
Duke Cancer Institute,
Institutes and Centers
Member of the Duke Human Vaccine Institute
·
2019 - Present
Duke Human Vaccine Institute,
Institutes and Centers
Recent Publications
The coronavirus nsp14 exoribonuclease interface with the cofactor nsp10 is essential for efficient virus replication and enzymatic activity.
Journal Article J Virol · February 25, 2025 Coronaviruses (CoVs) encode non-structural proteins (nsp's) 1-16, which assemble to form replication-transcription complexes that function in viral RNA synthesis. All CoVs encode a proofreading 3'-5' exoribonuclease in non-structural protein 14 (nsp14-ExoN ... Full text Link to item CiteInfluenza B virus infection alters the regenerative potential of murine alveolar type 2 pneumocytes.
Journal Article mBio · February 5, 2025 UNLABELLED: Respiratory epithelial cells can survive direct infection by influenza viruses, and the long-term consequences of that infection have been characterized in a subset of proximal airway cell types. The impact on the cells that survive viral infec ... Full text Link to item CiteAdministration of antigenically distinct influenza viral particle combinations as an influenza vaccine strategy.
Journal Article PLoS Pathog · January 2025 One approach for developing a more universal influenza vaccine is to elicit strong immune responses against canonically immunosubdominant epitopes in the surface exposed viral glycoproteins. While standard vaccines typically induce responses directed prima ... Full text Link to item CiteRecent Grants
ETS-family Transcription Factor Mediated Control of Pulmonary Inflammation Induced by Influenza Viruses
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2023 - 2028Ferroptosis and Ferroptotic Stress in Maladaptive Renal Repair - R01
ResearchCollaborator · Awarded by National Institute of Diabetes and Digestive and Kidney Diseases · 2023 - 2028Control of virus induced type I interferon signaling during pregnancy
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027View All Grants
Education, Training & Certifications
The University of Chicago ·
2012
Ph.D.