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Jeffrey John Nienaber

Assistant Consulting Professor in the Department of Surgery
Surgery, Vascular and Endovascular Surgery
Box 31153 Med Ctr, Durham, NC 27710
Dept of Surgery, Durham, NC 27710

Selected Publications


Normal cardiac function in mice with supraphysiological cardiac creatine levels.

Journal Article Am J Physiol Heart Circ Physiol · February 2014 Creatine and phosphocreatine levels are decreased in heart failure, and reductions in myocellular phosphocreatine levels predict the severity of the disease and portend adverse outcomes. Previous studies of transgenic mouse models with increased creatine c ... Full text Link to item Cite

Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction.

Journal Article Hum Gene Ther · October 2012 Adeno-associated virus type 3b (AAV3b) has been largely ignored by gene therapists because of the inability of vectors based on this serotype to transduce target tissues efficiently. Here we describe a phenomenon unique to AAV3b in that vectors based on th ... Full text Link to item Cite

Endogenous S-nitrosothiols protect against myocardial injury.

Journal Article Proc Natl Acad Sci U S A · April 14, 2009 Despite substantial evidence that nitric oxide (NO) and/or endogenous S-nitrosothiols (SNOs) exert protective effects in a variety of cardiovascular diseases, the molecular details are largely unknown. Here we show that following left coronary artery ligat ... Full text Link to item Cite

"Real world" thoracic endografting: results with the Gore TAG device 2 years after U.S. FDA approval.

Journal Article Ann Thorac Surg · November 2008 BACKGROUND: The Gore TAG thoracic endoprosthesis (W. L. Gore and Associates, Flagstaff, AZ) was approved by the U.S. Food and Drug Administration (FDA) for the treatment of thoracic aortic aneurysms on March 23, 2005, and remains the only FDA approved thor ... Full text Link to item Cite

Use of custom Dacron branch grafts for "hybrid" aortic debranching during endovascular repair of thoracic and thoracoabdominal aortic aneurysms.

Journal Article J Thorac Cardiovasc Surg · July 2008 OBJECTIVES: A significant number of patients with thoracic and thoracoabdominal aortic aneurysms are unsuitable for endovascular repair owing to the absence of graft seal zones. "Hybrid" techniques, including open aortic debranching procedures, allow creat ... Full text Link to item Cite

Dynamic regulation of phosphoinositide 3-kinase-gamma activity and beta-adrenergic receptor trafficking in end-stage human heart failure.

Journal Article Circulation · November 27, 2007 BACKGROUND: Downregulation of beta-adrenergic receptors (betaARs) under conditions of heart failure requires receptor targeting of phosphoinositide 3-kinase (PI3K)-gamma and redistribution of betaARs into endosomal compartments. Because support with a left ... Full text Link to item Cite

Minitransseptal versus left atrial approach to the mitral valve: a comparison of outcomes.

Journal Article Ann Thorac Surg · September 2006 BACKGROUND: Approaches to the mitral valve include left atriotomy (LA) through the interatrial groove and transseptal approach (TS) through the right atrium. Left atriotomy is more commonly used, but TS offers better mitral visualization in difficult cases ... Full text Link to item Cite

Inhibition of receptor-localized PI3K preserves cardiac beta-adrenergic receptor function and ameliorates pressure overload heart failure.

Journal Article J Clin Invest · October 2003 beta-Adrenergic receptor (betaAR) downregulation and desensitization are hallmarks of the failing heart. However, whether abnormalities in betaAR function are mechanistically linked to the cause of heart failure is not known. We hypothesized that downregul ... Full text Link to item Cite

G-protein-coupled receptor function in heart failure.

Journal Article Cold Spring Harb Symp Quant Biol · 2002 Full text Link to item Cite

Beta-adrenergic axis and heart disease.

Journal Article Trends Genet · October 2001 Beta-adrenergic receptors (beta-ARs) belong to a large family of G-protein-coupled receptors (GPCRs) that form the interface between the sympathetic nervous system and the cardiovascular system. The beta-AR signal system is one of the most powerful regulat ... Full text Link to item Cite