Overview
Dr. Nicole Pelot is a biomedical engineer at Duke University, conducting neural engineering research with a focus on neuromodulation of the autonomic nervous system, including anatomical studies, extensive development of computational methods to build anatomically realistic models of nerve stimulation, optimization methods to develop improved therapies, and in vivo electrophysiology. Nikki leads a team of researchers at Duke and works closely with collaborators at other institutions.
She earned her Bachelor's of Electrical Engineering and Bachelor's of Science (Physics) at Dalhousie University (Halifax, NS, Canada). She then earned her PhD in Biomedical Engineering at Duke University (Durham, NC, USA).
In addition to scientific excellence, she continually works to improve her academic project management and mentorship skills. Outside of research, Nikki is a dancer, yogi, and backpacker.
Current Appointments & Affiliations
Recent Publications
Automated 3D Segmentation of Human Vagus Nerve Fascicles and Epineurium from Micro-Computed Tomography Images Using Anatomy-Aware Neural Networks
Preprint · June 15, 2025 Full text CiteRamped kilohertz-frequency signals produce nerve conduction block without onset response.
Journal Article Journal of neural engineering · May 2025 Objective.Reversible block of peripheral nerve conduction using kilohertz-frequency (KHF) electrical signals has substantial potential for treating diseases. However, onset response, i.e. KHF-induced excitation en route to producing nerve block, is ... Full text CiteScaling of vagus nerve stimulation parameters does not achieve equivalent nerve responses across species.
Journal Article Bioelectronic medicine · May 2025 BackgroundPrevious efforts to translate vagus nerve stimulation (VNS) therapies from preclinical studies to human clinical applications (e.g., for stroke, heart failure, and inflammatory diseases) did not account for individual- or species-specifi ... Full text CiteRecent Grants
Optimized Electrical Block of Peripheral Nerves
ResearchResearch Scientist · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2027A Rational Engineering Design Approach to Minimizing the Off-Target Effects of Baroreceptor Activation Therapy
ResearchPrincipal Investigator · Awarded by University of Wisconsin - Madison · 2022 - 2026Mapping the Autonomic Pathways across 100 Human Vagus Nerves within a Demographically Representative Sample (MAP-100VN)
ResearchPrincipal Investigator · Awarded by Case Western Reserve University · 2022 - 2025View All Grants