Overview
Dr. Nicole Pelot is a biomedical engineer at Duke University, conducting neural engineering research with a focus on neuromodulation of the autonomic nervous system, including anatomical studies, extensive development of computational methods to build anatomically realistic models of nerve stimulation, optimization methods to develop improved therapies, and in vivo electrophysiology. Nikki leads a team of researchers at Duke and works closely with collaborators at other institutions.
She earned her Bachelor's of Electrical Engineering and Bachelor's of Science (Physics) at Dalhousie University (Halifax, NS, Canada). She then earned her PhD in Biomedical Engineering at Duke University (Durham, NC, USA).
In addition to scientific excellence, she continually works to improve her academic project management and mentorship skills. Outside of research, Nikki is a dancer, yogi, and backpacker.
Current Appointments & Affiliations
Recent Publications
Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.
Journal Article Journal of neural engineering · May 2026 Objective.Electrical stimulation of the baroreceptors pathways at the carotid sinus bulb-known as baroreflex activation therapy (BAT)-is intended to change autonomic tone and ultimately reduce blood pressure (BP) and heart rate. BAT is pre-market ap ... Full text CiteIntraoperative Laryngeal Muscle and Heart Rate Responses to Implanted Vagus Nerve Stimulation.
Journal Article Neuromodulation · April 22, 2026 OBJECTIVES: Implanted cervical vagus nerve stimulation (VNS) is used to treat refractory epilepsy, depression, stroke sequelae, and rheumatoid arthritis. It is necessary to understand the recruitment of different neural elements in response to VNS to uncov ... Full text Link to item CiteComputational modeling of human vagus nerve stimulation with three-dimensional fascicular morphology.
Journal Article APL bioengineering · March 2026 Implanted vagus nerve stimulation is FDA-approved to treat epilepsy, depression, and stroke sequelae and is under development for other disorders such as heart failure and rheumatoid arthritis. Anatomically realistic computational models enable the design ... Full text CiteRecent Grants
Optimized Electrical Block of Peripheral Nerves
ResearchResearch Scientist · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2027Project 1: Re-Envisioning Implanted Vagus Nerve Stimulation
ResearchPrincipal Investigator · Awarded by Zabara Foundation · 2026 - 2027Non-Invasive Magnetic Vagus Nerve Stimulation
ResearchCo Investigator · Awarded by Zabara Foundation · 2026 - 2027View All Grants