Overview
Dr. Nicole Pelot is a biomedical engineer at Duke University, conducting neural engineering research with a focus on neuromodulation of the autonomic nervous system, including anatomical studies, extensive development of computational methods to build anatomically realistic models of nerve stimulation, optimization methods to develop improved therapies, and in vivo electrophysiology. Nikki leads a team of researchers at Duke and works closely with collaborators at other institutions.
She earned her Bachelor's of Electrical Engineering and Bachelor's of Science (Physics) at Dalhousie University (Halifax, NS, Canada). She then earned her PhD in Biomedical Engineering at Duke University (Durham, NC, USA).
In addition to scientific excellence, she continually works to improve her academic project management and mentorship skills. Outside of research, Nikki is a dancer, yogi, and backpacker.
Current Appointments & Affiliations
Recent Publications
Identification of low threshold off-target activation pathways during stimulation of carotid baroreceptor afferents in swine.
Journal Article bioRxiv · January 2, 2026 OBJECTIVE: Electrical stimulation of the baroreceptors pathways at the carotid sinus bulb - known as baroreflex activation therapy (BAT) - is intended to change autonomic tone and ultimately reduce blood pressure and heart rate. BAT is pre-market approved ... Full text Link to item CiteAutomated 3D segmentation of human vagus nerve fascicles and epineurium from micro-computed tomography images using anatomy-aware neural networks.
Journal Article Journal of neural engineering · January 2026 Objective.Precise segmentation and quantification of nerve morphology from imaging data are critical for designing effective and selective peripheral nerve stimulation (PNS) therapies. However, prior studies on nerve morphology segmentation suffer f ... Full text CitePyFibers: An open-source NEURON-Python package to simulate responses of model nerve fibers to electrical stimulation.
Journal Article PLoS computational biology · December 2025 Computational modeling of peripheral nerve fibers is a key tool for designing improved neuromodulation therapies. The NEURON software is commonly used to create biophysical simulations of nerve fibers, often in the outdated HOC language. Whether written in ... Full text CiteRecent Grants
Optimized Electrical Block of Peripheral Nerves
ResearchResearch Scientist · Awarded by National Institute of Neurological Disorders and Stroke · 2023 - 2027Project 3: Treatment of Cellular Dysfunction with Electromagnetic Radiation
ResearchPrincipal Investigator · Awarded by Zabara Foundation · 2025 - 2026A Rational Engineering Design Approach to Minimizing the Off-Target Effects of Baroreceptor Activation Therapy
ResearchPrincipal Investigator · Awarded by University of Wisconsin - Madison · 2022 - 2026View All Grants