Overview
My research interest includes understanding host-pathogen interactions, specifically how the host cell state can influence viral fate and how viruses can reshape host cell state. I completed my molecular microbiology PhD in the lab of Dr. Iván D’Orso at UT Southwestern Medical Center. During my PhD, I identified a previously undescribed host factor that could tune T cell resting to active state transition and promotes latent HIV-1 reactivation. Currently, in Dr. Carolyn Coyne’s lab here at Duke, my research is focused on studying how enteroviruses can reshape the host cellular and transcriptional landscape to elude the innate anti-viral response using enteroids, 3-D organoid models of the gut.
Current Appointments & Affiliations
Postdoctoral Associate
Molecular Genetics and Microbiology,
Basic Science Departments
Recent Publications
Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity.
Journal Article Viruses · October 2022 Immune cell state alterations rewire HIV-1 gene expression, thereby influencing viral latency and reactivation, but the mechanisms are still unfolding. Here, using a screen approach on CD4+ T cell models of HIV-1 latency, we revealed Small Molec ... Full text CiteADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis.
Journal Article Nature communications · March 2022 Immune stimulation fuels cell signaling-transcriptional programs inducing biological responses to eliminate virus-infected cells. Yet, retroviruses that integrate into host cell chromatin, such as HIV-1, co-opt these programs to switch between latent and r ... Full text CiteHIV-1 Proviral Transcription and Latency in the New Era.
Journal Article Viruses · May 2020 Three decades of extensive work in the HIV field have revealed key viral and host cell factors controlling proviral transcription. Various models of transcriptional regulation have emerged based on the collective information from in vitro assays and work i ... Full text CiteRecent Grants
Enterovirus Infection of Polarized Intestinal Cells
ResearchPostdoctoral Associate · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026The Role of FcRn in Echovirus Entry and Pathogenesis
ResearchPostdoctoral Associate · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2026View All Grants