Scholars@Duke
Eleonora Georgeta Lad

Eleonora Georgeta Lad

Professor of Ophthalmology
Ophthalmology, Vitreoretinal Diseases & Surgery
nora.lad@duke.edu
Duke Eye Center, DUMC 3802, Durham, NC 27710
Duke Eye Center, 2351 Erwin Road DUMC 3802, Durham, NC 27705

Scholarly Works - Journal articles

LONG-TERM EFFICACY AND SAFETY OF PHOTOBIOMODULATION IN DRY AGE-RELATED MACULAR DEGENERATION (LIGHTSITE III: 24-MONTH ANALYSIS).

Journal article Retina · May 1, 2026 PURPOSE: To evaluate the safety and efficacy of multiwavelength photobiomodulation (PBM) in nonexudative (dry) age-related macular degeneration (AMD). METHODS: LIGHTSITE III used a double-masked, randomized, sham-controlled, parallel-group, prospective stu ... Full text Link to item Cite

HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement.

Journal article Nat Commun · December 8, 2025 Age-related macular degeneration (AMD) is a multifactorial retinal disease with a large genetic risk contribution. Reticular pseudodrusen (RPD) is a sub-phenotype of AMD with a high risk of progression to late vision threatening AMD. In a genome-wide assoc ... Full text Link to item Cite

Deep Learning Algorithm for the Diagnosis and Prediction of Hydroxychloroquine Retinopathy: An International, Multi-institutional Study.

Journal article Ophthalmol Retina · December 2025 PURPOSE: We present a deep learning algorithm-HCQuery-that detects the presence of hydroxychloroquine retinopathy and predicts its future occurrence from spectral-domain OCT (SD-OCT) images. DESIGN: We trained and validated a deep learning algorithm using ... Full text Link to item Cite

Parsing the Heterogeneity of Geographic Atrophy.

Journal article JAMA Ophthalmol · December 1, 2025 Full text Link to item Cite

Association of National Eye Institute Visual Function Questionnaire 39 Scores With Visual Function in Age-related Macular Degeneration Over 24 Months.

Journal article Ophthalmic Surg Lasers Imaging Retina · September 2025 BACKGROUND AND OBJECTIVE: The aim of this study was to determine the National Eye Institute Visual Function Questionnaire 39 (NEI-VFQ39) score association with visual function (VF) tests in early (eAMD) and intermediate (iAMD) age-related macular degenerat ... Full text Link to item Cite

Natural History of Microperimetry and Optical Coherence Tomography in USH2A-Retinopathy: A Structure-Function Association Study.

Journal article Am J Ophthalmol · August 2025 PURPOSE: To describe the natural history of optical coherence tomography (OCT) and mesopic microperimetry (MP) parameters in the Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN: Multicenter, international, prospective, long ... Full text Link to item Cite

Pegcetacoplan for Geographic Atrophy Over 30 Months: Data From OAKS, DERBY, and the GALE Long-Term Extension Study.

Journal article Ophthalmic Surg Lasers Imaging Retina · July 2025 BACKGROUND AND OBJECTIVE: This study will report safety and efficacy of pegcetacoplan for geographic atrophy (GA) secondary to age-related macular degeneration (AMD). PATIENTS AND METHODS: GALE is a phase 3, open-label, multicenter, 36-month extension of t ... Full text Link to item Cite

Visual Loss in Geographic Atrophy: Learnings from the Lampalizumab Trials.

Journal article Ophthalmology · April 2025 PURPOSE: To assess the correlation of lesion growth rate and baseline factors, including foveal involvement and focality, on visual loss as measured by best-corrected visual acuity (BCVA) in patients with geographic atrophy (GA) secondary to age-related ma ... Full text Link to item Cite

Endpoints and Design for Clinical Trials in USH2A-Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study.

Journal article Transl Vis Sci Technol · October 1, 2024 PURPOSE: To evaluate functional and structural assessments as endpoints for clinical trials for USH2A-related retinal degeneration. METHODS: People with biallelic disease-causing variants in USH2A, visual acuity ≥ 20/80, and visual field ≥ 10° diameter wer ... Full text Link to item Cite

Informing Endpoints for Clinical Trials of Geographic Atrophy.

Journal article Annu Rev Vis Sci · September 2024 Geographic atrophy (GA), the non-neovascular advanced form of age-related macular degeneration, remains an important disease area in which treatment needs are currently unmet. Recent clinical trials using drugs that target the complement pathway have shown ... Full text Link to item Cite

LIGHTSITE III: 13-Month Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative (Dry) Age-Related Macular Degeneration Using the Lumithera Valeda Light Delivery System.

Journal article Retina · March 1, 2024 PURPOSE: The LIGHTSITE III study evaluated multiwavelength photobiomodulation (PBM) therapy in nonexudative (dry) age-related macular degeneration (AMD) using the LumiThera Valeda Light Delivery System. METHODS: LIGHTSITE III is a randomized, controlled tr ... Full text Link to item Cite

Activated cGAS/STING signaling elicits endothelial cell senescence in early diabetic retinopathy.

Journal article JCI Insight · June 22, 2023 Diabetic retinopathy (DR) is a leading cause of blindness in working-age adults and remains an important public health issue worldwide. Here we demonstrate that the expression of stimulator of interferon genes (STING) is increased in patients with DR and a ... Full text Link to item Cite

Robotic Optical Coherence Tomography Retinal Imaging for Emergency Department Patients: A Pilot Study for Emergency Physicians' Diagnostic Performance.

Journal article Ann Emerg Med · April 2023 STUDY OBJECTIVE: To evaluate the diagnostic performance of emergency physicians' interpretation of robotically acquired retinal optical coherence tomography images for detecting posterior eye abnormalities in patients seen in the emergency department (ED). ... Full text Link to item Cite

Baseline Microperimetry and OCT in the RUSH2A Study: Structure-Function Association and Correlation With Disease Severity.

Journal article Am J Ophthalmol · December 2022 PURPOSE: To investigate baseline mesopic microperimetry (MP) and spectral domain optical coherence tomography (OCT) in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. DESIGN: Natural history study METHODS: Setting: 16 clinical ... Full text Link to item Cite

C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration

Journal article International Journal of Retina and Vitreous · December 1, 2022 Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a retinal neurodegenerative disorder. Human genetic data support the complement system as a key component of pathogenesis in AMD, which has been further supported by pre-clinica ... Full text Cite

Natural history of central sparing in geographic atrophy secondary to non-exudative age-related macular degeneration.

Journal article Br J Ophthalmol · May 2022 BACKGROUND: The macular central 1 mm diameter zone is crucial to patients' visual acuity, but the long-term natural history of central sparing in eyes with geographic atrophy (GA) is unknown. METHODS: We manually segmented GA in 210 eyes with GA involving ... Full text Link to item Cite

From Data to Deployment: The Collaborative Community on Ophthalmic Imaging Roadmap for Artificial Intelligence in Age-Related Macular Degeneration.

Journal article Ophthalmology · May 2022 OBJECTIVE: Health care systems worldwide are challenged to provide adequate care for the 200 million individuals with age-related macular degeneration (AMD). Artificial intelligence (AI) has the potential to make a significant, positive impact on the diagn ... Full text Link to item Cite

Osteopontin accumulates in basal deposits of human eyes with age-related macular degeneration and may serve as a biomarker of aging.

Journal article Mod Pathol · February 2022 A common clinical phenotype of several neurodegenerative and systemic disorders including Alzheimer's disease and atherosclerosis is the abnormal accumulation of extracellular material, which interferes with routine cellular functions. Similarly, patients ... Full text Link to item Cite

Biomarkers for Nonexudative Age-Related Macular Degeneration and Relevance for Clinical Trials: A Systematic Review.

Journal article Mol Diagn Ther · November 2021 TOPIC: The purpose of the review was to identify structural, functional, blood-based, and other types of biomarkers for early, intermediate, and late nonexudative stages of age-related macular degeneration (AMD) and summarize the relevant data for proof-of ... Full text Link to item Cite

Relationship of Topographic Distribution of Geographic Atrophy to Visual Acuity in Nonexudative Age-Related Macular Degeneration.

Journal article Ophthalmol Retina · August 2021 PURPOSE: To investigate the topographic distribution of geographic atrophy (GA) and to identify an anatomic endpoint that correlates with visual acuity (VA) in eyes with GA. DESIGN: Retrospective analysis of a multicenter, prospective, randomized controlle ... Full text Link to item Cite

Impact of Baseline Characteristics on Geographic Atrophy Progression in the FILLY Trial Evaluating the Complement C3 Inhibitor Pegcetacoplan.

Journal article Am J Ophthalmol · July 2021 PURPOSE: To evaluate the effect of select baseline characteristics on geographic atrophy (GA) progression in eyes receiving intravitreal pegcetacoplan or sham. DESIGN: Phase 2 multicenter, randomized, single-masked, sham-controlled trial. METHODS: Patients ... Full text Link to item Cite

Fundus-controlled perimetry (microperimetry): Application as outcome measure in clinical trials.

Journal article Prog Retin Eye Res · May 2021 Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as well as research. The accurate spatial characterization of visua ... Full text Link to item Cite

Local Anatomic Precursors to New-Onset Geographic Atrophy in Age-Related Macular Degeneration as Defined on OCT.

Journal article Ophthalmol Retina · May 2021 PURPOSE: In macula-wide analyses, spectral-domain (SD) optical coherence tomography (OCT) features including drusen volume, hyperreflective foci, and OCT-reflective drusen substructures independently predict geographic atrophy (GA) onset secondary to age-r ... Full text Link to item Cite

Subretinal Mononuclear Cells in Coats' Disease Studied with RPE65 and CD163: Evidence for Histiocytoid Pigment Epithelial Cells.

Journal article Am J Ophthalmol · February 2021 PURPOSE: To evaluate the mononuclear cells in the subretinal exudate in Coats' disease. DESIGN: Retrospective case series. METHODS: Five enucleated globes and 1 cytology sample from a patient with Coats' disease and 1 case of chronic retinal detachment fol ... Full text Link to item Cite

Therapeutic Options Under Development for Nonneovascular Age-Related Macular Degeneration and Geographic Atrophy.

Journal article Drugs Aging · January 2021 Age-related macular degeneration (AMD) is a chronic, multifactorial disease and a leading cause of irreversible blindness in the elderly population in the Western Hemisphere. Among the two major subtypes of AMD, the prevalence of the nonneovascular (dry) t ... Full text Link to item Cite

Cerebral white matter connectivity, cognition, and age-related macular degeneration.

Journal article Neuroimage Clin · 2021 Age-related macular degeneration (AMD) is a common retina disease associated with cognitive impairment in older adults. The mechanism(s) that account for the link between AMD and cognitive decline remain unclear. Here we aim to shed light on this issue by ... Full text Open Access Link to item Cite

Relationship between neural functional connectivity and memory performance in age-related macular degeneration.

Journal article Neurobiol Aging · November 2020 Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and ... Full text Open Access Link to item Cite

The RUSH2A Study: Best-Corrected Visual Acuity, Full-Field Electroretinography Amplitudes, and Full-Field Stimulus Thresholds at Baseline.

Journal article Transl Vis Sci Technol · October 2020 PURPOSE: The purpose of this study was to evaluate baseline best corrected visual acuity (BCVA), full-field electroretinography (ERG), full-field stimulus thresholds (FST), and their relationship with baseline demographic and clinical characteristics in th ... Full text Open Access Link to item Cite

Co-Prevalence of Alzheimer's Disease and Age-Related Macular Degeneration Established by Histopathologic Diagnosis.

Journal article J Alzheimers Dis · 2020 BACKGROUND: Previous epidemiologic studies have suggested an association between AMD and AD, and several therapeutic agents are being developed based on this principle. However, prior studies have provided conflicting results due in part to their reliance ... Full text Link to item Cite

Longitudinal Study of Visual Function in Dry Age-Related Macular Degeneration at 12 Months.

Journal article Ophthalmol Retina · August 2019 PURPOSE: To report the 1-year progression of visual impairment on psychophysical tests of visual function in patients with early and intermediate age-related macular degeneration (AMD). DESIGN: Prospective, observational study. PARTICIPANTS: Patients with ... Full text Link to item Cite

Ocular amyloid imaging at the crossroad of Alzheimer's disease and age-related macular degeneration: implications for diagnosis and therapy.

Journal article J Neurol · July 2019 Alzheimer's disease (AD) and age-related macular degeneration (AMD) are important disorders of aging, but significant challenges remain in diagnosis and therapy. Amyloid-beta (Aβ), found in the brain and a defining feature of AD, has also been observed in ... Full text Link to item Cite

Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis.

Journal article Ophthalmology · April 2019 TOPIC: OCT is a noninvasive tool to measure specific retinal layers in the eye. The relationship of retinal spectral-domain (SD) OCT measurements with Alzheimer's disease (AD) and mild cognitive impairment (MCI) remains unclear. Hence, we conducted a syste ... Full text Link to item Cite

Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial.

Journal article Ophthalmology · April 2019 PURPOSE: To test the effects of an encapsulated cell-based delivery of a neuroprotective agent, ciliary neurotrophic factor (CNTF), on progression of macular telangiectasia type 2, a neurodegenerative disease with no proven effective therapy. DESIGN: Rando ... Full text Link to item Cite

Comorbidity of age-related macular degeneration with Alzheimer's disease: A histopathologic case-control study.

Journal article PLoS One · 2019 INTRODUCTION: Previous studies evaluating the association between clinically diagnosed Alzheimer's disease (AD) and age-related macular degeneration (AMD) have generated conflicting results. This study is the first to assess whether AMD prevalence is highe ... Full text Link to item Cite

CD163+ macrophages infiltrate axon bundles of postmortem optic nerves with glaucoma.

Journal article Graefes Arch Clin Exp Ophthalmol · December 2018 PURPOSE: Prior research in animal models has shown that macrophages and microglia play an important role in pathogenesis of glaucoma, but the phenotype and distribution of macrophages in human glaucomatous tissue have not been sufficiently characterized. M ... Full text Link to item Cite

Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration: Chroma and Spectri Phase 3 Randomized Clinical Trials.

Journal article JAMA Ophthalmol · June 1, 2018 IMPORTANCE: Geographic atrophy (GA) secondary to age-related macular degeneration is a leading cause of visual disability in older individuals. A phase 2 trial suggested that lampalizumab, a selective complement factor D inhibitor, reduced the rate of GA e ... Full text Link to item Cite

Visual Function Metrics in Early and Intermediate Dry Age-related Macular Degeneration for Use as Clinical Trial Endpoints.

Journal article Am J Ophthalmol · May 2018 PURPOSE: To evaluate and quantify visual function metrics to be used as endpoints of age-related macular degeneration (AMD) stages and visual acuity (VA) loss in patients with early and intermediate AMD. DESIGN: Cross-sectional analysis of baseline data fr ... Full text Link to item Cite

Review of Ophthalmology Medical Professional Liability Claims in the United States from 2006 through 2015.

Journal article Ophthalmology · May 2018 PURPOSE: To describe characteristics of closed medical professional liability (MPL) claims against ophthalmologists in the United States. DESIGN: Retrospective analysis of MPL claims from 2006-2015. Data were obtained from the Physician Insurers Associatio ... Full text Link to item Cite

Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration.

Journal article Invest Ophthalmol Vis Sci · January 1, 2018 PURPOSE: To determine whether Low Luminance Questionnaire (LLQ) scores are associated with objective measures of visual function in early and intermediate age-related macular degeneration (AMD). METHODS: Cross-sectional study of subjects with early AMD Age ... Full text Link to item Cite

Evaluation of inner retinal layers as biomarkers in mild cognitive impairment to moderate Alzheimer's disease.

Journal article PLoS One · 2018 Inner retina in Alzheimer's Disease (AD) may experience neuroinflammation resulting in atrophy. The objective of our study was to determine whether retinal GCIPL (ganglion cell-inner plexiform layer) or nerve fiber layer (NFL) thickness may serve as noninv ... Full text Link to item Cite

Relating Sensory, Cognitive, and Neural Factors to Older Persons' Perceptions about Happiness: An Exploratory Study.

Journal article J Aging Res · 2018 Despite increased rates of disease, disability, and social losses with aging, seniors consistently report higher levels of subjective well-being (SWB), a construct closely related to happiness, than younger adults. In this exploratory study, we utilized an ... Full text Open Access Link to item Cite

Retinal imaging in human autopsy eyes using a custom optical coherence tomography periscope.

Journal article Biomed Opt Express · September 1, 2017 Age-related macular degeneration (AMD) is a major cause of vision loss in the elderly. To better study the pathobiology of AMD, postmortem eyes offer an excellent opportunity to correlate optical coherence tomography (OCT) imaging characteristics with hist ... Full text Link to item Cite

Correlation Between Macular Integrity Assessment and Optical Coherence Tomography Imaging of Ellipsoid Zone in Macular Telangiectasia Type 2.

Journal article Invest Ophthalmol Vis Sci · May 1, 2017 PURPOSE: To correlate ellipsoid zone (EZ) defects on spectral-domain optical coherence tomography (SD-OCT) with retinal sensitivity loss on macular integrity assessment (MAIA) microperimetry in macular telangiectasia type 2 (MacTel). METHODS: Macular SD-OC ... Full text Link to item Cite

Ocular histopathology in Eastern equine encephalitis: A case report.

Journal article Am J Ophthalmol Case Rep · April 2017 PURPOSE: To describe the ophthalmic symptoms and histopathological findings in a human case of Eastern equine encephalitis (EEE). OBSERVATIONS: The patient was a septuagenarian male whose presentation and clinical course were thought to be most consistent ... Full text Link to item Cite

Wide-field retinal optical coherence tomography with wavefront sensorless adaptive optics for enhanced imaging of targeted regions.

Journal article Biomed Opt Express · January 1, 2017 The peripheral retina of the human eye offers a unique opportunity for assessment and monitoring of ocular diseases. We have developed a novel wide-field (>70°) optical coherence tomography system (WF-OCT) equipped with wavefront sensorless adaptive optics ... Full text Link to item Cite

VISUAL FUNCTION MEASURES IN EARLY AND INTERMEDIATE AGE-RELATED MACULAR DEGENERATION.

Journal article Retina · May 2016 PURPOSE: The objectives of this study were to evaluate 1) the feasibility of performing computerized tests of low luminance visual acuity (LLVA), cone-specific contrast (Cone Contrast Test [CCT]), contrast sensitivity, and microperimetry and 2) the test-re ... Full text Link to item Cite

Relating Retinal Morphology and Function in Aging and Early to Intermediate Age-related Macular Degeneration Subjects.

Journal article Am J Ophthalmol · May 2016 PURPOSE: To evaluate relationships between age-related macular degeneration (AMD) morphology on spectral-domain optical coherence tomography (SDOCT) and visual function. DESIGN: Cross-sectional, observational. METHODS: From the Alabama Study on Early AMD b ... Full text Link to item Cite

Semiautomatic Segmentation of Rim Area Focal Hyperautofluorescence Predicts Progression of Geographic Atrophy Due to Dry Age-Related Macular Degeneration.

Journal article Invest Ophthalmol Vis Sci · April 1, 2016 PURPOSE: To develop image analysis software usable by nonexpert graders to segment geographic atrophy (GA) from dry AMD and to quantify rim area focal hyperautofluorescence (RAFH) surrounding GA on fundus autofluorescence (FAF) images. To compare the GA pr ... Full text Link to item Cite

Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study.

Journal article Am J Ophthalmol · April 2016 PURPOSE: To describe fluocinolone acetonide implant dissociations in the Multicenter Uveitis Steroid Treatment (MUST) Trial. DESIGN: Randomized clinical trial with extended follow-up. METHODS: Review of data collected on the first implant in the eye(s) of ... Full text Link to item Cite

Individual Differences in Scotopic Visual Acuity and Contrast Sensitivity: Genetic and Non-Genetic Influences.

Journal article PLoS One · 2016 Despite the large amount of variation found in the night (scotopic) vision capabilities of healthy volunteers, little effort has been made to characterize this variation and factors, genetic and non-genetic, that influence it. In the largest population of ... Full text Link to item Cite

Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial.

Journal article Am J Ophthalmol · December 2015 PURPOSE: To identify factors associated with best-corrected visual acuity (BCVA) presentation and 2-year outcome in 479 intermediate, posterior, and panuveitic eyes. DESIGN: Cohort study using randomized controlled trial data. METHODS: Multicenter Uveitis ... Full text Link to item Cite

Outcome of Treatment of Uveitic Macular Edema: The Multicenter Uveitis Steroid Treatment Trial 2-Year Results.

Journal article Ophthalmology · November 2015 PURPOSE: To evaluate the 2-year outcomes of uveitic macular edema. DESIGN: Longitudinal follow-up of a randomized cohort. PARTICIPANTS: At baseline, 148 eyes of 117 patients enrolled in the Multicenter Uveitis Steroid Treatment (MUST) Trial had macular ede ... Full text Link to item Cite

Phonemic fluency and brain connectivity in age-related macular degeneration: a pilot study.

Journal article Brain Connect · March 2015 Age-related macular degeneration (AMD), the leading cause of blindness in developed nations, has been associated with poor performance on tests of phonemic fluency. This pilot study sought to (1) characterize the relationship between phonemic fluency and r ... Full text Open Access Link to item Cite

Co-occurrence of a cerebral cavernous malformation and an orbital cavernous hemangioma in a patient with seizures and visual symptoms: Rare crossroads for vascular malformations

Journal article Surgical Neurology International · January 1, 2014 Background: Cerebral cavernous malformations (CCMs) are angiographically occult vascular malformations of the central nervous system. As a result of hemorrhage and mass effect, patients may present with focal neurologic deficits, seizures, and other sympto ... Full text Cite

Costs of newly diagnosed neovascular age-related macular degeneration among medicare beneficiaries, 2004-2008.

Journal article Retina · April 2013 PURPOSE: To examine associations between newly diagnosed neovascular age-related macular degeneration and direct medical costs. METHODS: This retrospective observational study matched 23,133 Medicare beneficiaries diagnosed with neovascular age-related mac ... Full text Link to item Cite

Complete visual recovery after incipient crao due to ocular hypoperfusion in a patient with moyamoya disease.

Journal article Retin Cases Brief Rep · 2013 PURPOSE: The purpose of this study was to report a case of an impending central retinal artery occlusion with hypoperfusion in a moyamoya patient. METHODS: A young, surgically revascularized moyamoya patient experienced severe unilateral vision loss from 2 ... Full text Link to item Cite

Orbital fractures: national inpatient trends and complications.

Journal article Ophthalmic Plast Reconstr Surg · 2013 PURPOSE: The present study aimed to examine cost, demographics, and short-term complications associated with orbital fractures and their surgical repair in the inpatient population in the United States over a 7-year period. METHODS: A retrospective cohort ... Full text Link to item Cite

Effect of lidocaine gel anesthesia on endophthalmitis rates following intravitreal injection.

Journal article Ophthalmic Surg Lasers Imaging · 2012 BACKGROUND AND OBJECTIVE: To determine whether the use of lidocaine gel before application of povidone-iodine affects endophthalmitis rates following intravitreal injections. PATIENTS AND METHODS: Retrospective consecutive case series of all intravitreal i ... Full text Link to item Cite

Stanford University network for diagnosis of retinopathy of prematurity (SUNDROP): 36-month experience with telemedicine screening.

Journal article Ophthalmic Surg Lasers Imaging · 2011 Featured Publication BACKGROUND AND OBJECTIVE: to report the 36-month experience of the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) telemedicine initiative. PATIENTS AND METHODS: retrospective analysis of the SUNDROP archival data between ... Full text Link to item Cite

Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP): 24-month experience with telemedicine screening.

Journal article Acta Ophthalmol · May 2010 PURPOSE: To report the 24-month experience of the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) telemedicine initiative. METHODS: Retrospective analysis of the SUNDROP archival data gathered between 1 December 2005 and 3 ... Full text Link to item Cite

Orbital recurrence of B-progenitor acute lymphoblastic leukemia in a child.

Journal article J Pediatr Ophthalmol Strabismus · 2010 Featured Publication Orbital mass is an exceedingly rare presentation of acute lymphoblastic leukemia. This report describes a 12-year-old boy with recurrent orbital pre-B-cell acute lymphoblastic leukemia and reviews the literature on the incidence, presentation, prognosis, a ... Full text Link to item Cite

Incidence of retinopathy of prematurity in the United States: 1997 through 2005.

Journal article Am J Ophthalmol · September 2009 Featured Publication PURPOSE: To determine the incidence of retinopathy of prematurity (ROP) based on a national database and to identify baseline characteristics, demographic information, comorbidities, and surgical interventions. DESIGN: Retrospective study based on the Nati ... Full text Link to item Cite

Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian rats.

Journal article J Comp Neurol · July 1, 2009 Featured Publication Clinical trials of neural grafting for Parkinson's disease (PD) have produced variable, but overall disappointing, results. One particular disappointment has been the development of aberrant motor complications following dopamine (DA) neuron grafting. Desp ... Full text Link to item Cite

National trends in vertebral augmentation procedures for the treatment of vertebral compression fractures.

Journal article Surg Neurol · May 2009 BACKGROUND: Vertebral compression fractures represent a serious health care problem. Vertebroplasty and kyphoplasty have been gaining popularity in the treatment of symptomatic compression fractures that are often secondary to osteoporosis or neoplasia. ME ... Full text Link to item Cite

Wnt-signaling in retinal development and disease.

Journal article Stem Cells Dev · 2009 Featured Publication The Wnt-signaling pathway is a known regulator of stem cell maintenance, cellular proliferation and differentiation, and cancer development in various tissues. Wnt proteins play a central role during various stages of retinal development; retinal field est ... Full text Link to item Cite

Intravitreal injection of therapeutic agents.

Journal article Retina · 2009 Featured Publication BACKGROUND: Intravitreal injection (IVI) with administration of various pharmacological agents is a mainstay of treatment in ophthalmology for endopthalmitis, viral retinitis, age-related macular degeneration, cystoid macular edema, diabetic retinopathy, u ... Full text Link to item Cite

Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP): 18-month experience with telemedicine screening.

Journal article Graefes Arch Clin Exp Ophthalmol · January 2009 PURPOSE: To report the 18-month experience of the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) telemedicine initiative. DESIGN: Retrospective analysis of the SUNDROP archival data between 1 December 2005 and 30 May 2007 ... Full text Link to item Cite

Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP): 12-month experience with telemedicine screening.

Journal article Br J Ophthalmol · November 2008 BACKGROUND/AIMS: To report the 1-year experience of the Stanford University Network for Diagnosis of Retinopathy of Prematurity (SUNDROP) telemedicine initiative. METHODS: Forty-two consecutively enrolled infants who met ROP examination criteria were scree ... Full text Link to item Cite

Visual loss after spine surgery: a population-based study.

Journal article Spine (Phila Pa 1976) · June 1, 2008 STUDY DESIGN: Retrospective cohort study using National inpatient sample administrative data. OBJECTIVE: To determine national estimates of visual impairment and ischemic optic neuropathy after spine surgery. SUMMARY OF BACKGROUND DATA: Loss of vision afte ... Full text Link to item Cite

Retinopathy of prematurity in the United States.

Journal article Br J Ophthalmol · March 2008 Featured Publication AIMS: To determine the incidence of retinopathy of prematurity (ROP) based upon a national database and to identify baseline characteristics, demographic information, comorbidities, and surgical interventions. METHODS: The National Inpatient Sample, a repr ... Full text Link to item Cite

Trends in pathological vertebral fractures in the United States: 1993 to 2004.

Journal article J Neurosurg Spine · September 2007 OBJECT: Pathological vertebral fractures (PVFs) are an increasingly important cause of disability and have many clinical and economic implications. The authors examined trends in epidemiology and surgical management of pathological vertebral fractures in t ... Full text Link to item Cite

Hippocrates' influence on the origins of neurosurgery.

Journal article Neurosurg Focus · 2007 Hippocrates is widely considered the father of medicine. His contributions revolutionized the practice of medicine and laid the foundation for modern-day neurosurgery. He inspired several generations to follow his vision, by pioneering the rigorous clinica ... Full text Link to item Cite

Minimizing the risk of endophthalmitis following intravitreal injections.

Journal article Compr Ophthalmol Update · 2006 Featured Publication Over the last decade, the use of intravitreal injections has gained increasing popularity in the treatment of many intraocular disorders. Intravitreal injections have been employed to deliver antibiotics, antivirals, steroids, gas, and antivascular endothe ... Link to item Cite

Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.

Journal article Neurobiol Dis · January 2006 Featured Publication Dyskinesias are a common consequence of dopaminergic therapy in patients with Parkinson's disease. Little is known about the influence of cellular replacement strategies upon drug-induced dyskinesias. In the current study, we employed parkinsonian rats to ... Full text Link to item Cite

The role of alpha-synuclein in Parkinson's disease: insights from animal models.

Journal article Nat Rev Neurosci · September 2003 Featured Publication Full text Link to item Cite

Etiology of Parkinson's disease: Genetics and environment revisited.

Journal article Proc Natl Acad Sci U S A · October 29, 2002 Featured Publication Full text Link to item Cite

Multiple paternity in the nurse shark, Ginglymostoma Cirratum

Journal article Envir Biol Fishes · 2002 Cite