Scholars@Duke
Nosayaba Osazuwa-Peters

Nosayaba Osazuwa-Peters

Associate Professor in Head and Neck Surgery & Communication Sciences
Head & Neck Surgical Oncology
4212 Orange Zone, Box 3805, Durham, NC 27710
DUMC 3805, Durham, NC 27710

Scholarly Works - Other

Data from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <div><p>Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding th ... Full text Cite

Table S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki ... Full text Cite

FIGURE 2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Pseudodeconvolution of ONB bulk RNA-seq defines proportions of cell type–specific transcriptomics across low- and high-grade tumors. <b>A,</b> Stacked bar chart depicts predicted proportions of cell types in bulk tumors when ma ... Full text Cite

FIGURE 4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>PRC2 complex expression in ONB. <b>A,</b> PRC2 transcripts in the core complex are mostly upregulated in high-grade ONB. <b>B,</b> EPOP expression is significantly increased in high-grade ONB compared with low grade ... Full text Cite

Figure S4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Additional Kaplan-Meier survival curves based on Hyams Grade, Dulguerov T-stage, and MKI67 gene expression. Log-rank test used to determine statistical significance.</p> ... Full text Cite

FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Patterns of gene expression in the normal differentiating OE. <b>A,</b> Trajectory UMAP depicting differentiation states across pseudotime, in seven normal olfactory mucosa biopsies scRNA-seq from Durante and colleagues, 2020 a ... Full text Cite

Figure S2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control ... Full text Cite

FIGURE 1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Schematic of the deconvolution workflow. Diagram of normal OE in the top left colored by cell identity (HBC: yellow; GBC: pink; immature OSN: blue; mature OSN: orange; Sustentacular: green; Bowman's Gland: purple; Olfactory ensheating cell ... Full text Cite

Figure S3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.</p> ... Full text Cite

Figure S4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Additional Kaplan-Meier survival curves based on Hyams Grade, Dulguerov T-stage, and MKI67 gene expression. Log-rank test used to determine statistical significance.</p> ... Full text Cite

FIGURE 3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Patterns of gene expression in the normal differentiating OE. <b>A,</b> Trajectory UMAP depicting differentiation states across pseudotime, in seven normal olfactory mucosa biopsies scRNA-seq from Durante and colleagues, 2020 a ... Full text Cite

Table S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki ... Full text Cite

FIGURE 1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Schematic of the deconvolution workflow. Diagram of normal OE in the top left colored by cell identity (HBC: yellow; GBC: pink; immature OSN: blue; mature OSN: orange; Sustentacular: green; Bowman's Gland: purple; Olfactory ensheating cell ... Full text Cite

Figure S2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control ... Full text Cite

Data from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <div><p>Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Because of the low incidence of this tumor, as well as an absence of established cell lines and murine models, understanding th ... Full text Cite

Figure S3 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.</p> ... Full text Cite

FIGURE 2 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Pseudodeconvolution of ONB bulk RNA-seq defines proportions of cell type–specific transcriptomics across low- and high-grade tumors. <b>A,</b> Stacked bar chart depicts predicted proportions of cell types in bulk tumors when ma ... Full text Cite

Figure S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu ... Full text Cite

FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Glandular and olfactory ensheathing cell markers are present in low-grade ONB and are associated with increased survival. <b>A,</b> UMAP visualization of non-tumor olfactory mucosa scRNA-seq data depicts the cell type–specific ... Full text Cite

FIGURE 5 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>Glandular and olfactory ensheathing cell markers are present in low-grade ONB and are associated with increased survival. <b>A,</b> UMAP visualization of non-tumor olfactory mucosa scRNA-seq data depicts the cell type–specific ... Full text Cite

Figure S1 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu ... Full text Cite

FIGURE 4 from Deconstructing Olfactory Epithelium Developmental Pathways in Olfactory Neuroblastoma

Other · June 6, 2023 <p>PRC2 complex expression in ONB. <b>A,</b> PRC2 transcripts in the core complex are mostly upregulated in high-grade ONB. <b>B,</b> EPOP expression is significantly increased in high-grade ONB compared with low grade ... Full text Cite

Figure S3 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.</p> ... Full text Cite

Table S1 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki ... Full text Cite

Figure S1 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu ... Full text Cite

Figure S2 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control ... Full text Cite

Figure S3 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Identical RNA expression plots to those shown in Fig. 4 A and B, but with IDH2 mutant ONB separated out from wild type tumors.</p> ... Full text Cite

Figure S4 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Additional Kaplan-Meier survival curves based on Hyams Grade, Dulguerov T-stage, and MKI67 gene expression. Log-rank test used to determine statistical significance.</p> ... Full text Cite

Table S1 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Tumor demographics separated by Hyams grade, Dulguerov T stage, and gene expression groups (low versus high) used for survival analysis in Figure 5 and Figure S4. Average Ki-67 mRNA expression obtained from bulk RNA-Seq outputs. Average Ki ... Full text Cite

Figure S1 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>A and B identical to Figure 2A and B, but with the two IDH2 mutant tumors separated out from the other tumors into their own category. C shows estimated respiratory cell type proportions across normal OE, low grade, high grade, and IDH2 mu ... Full text Cite

Data from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <div>Abstract<p>Olfactory neuroblastoma is a rare tumor arising from the olfactory cleft region of the nasal cavity. Due to the low incidence of this tumor, as well as an absence of established cell lines and murine models, understandin ... Full text Cite

Figure S2 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>RNA expression signatures of ONB from Classe et al., 2018 based on markers traditionally associated with sinonasal undifferentiated carcinoma (A), small cell neuroendocrine carcinoma (B), and olfactory neuroblastoma (C), divided by control ... Full text Cite

Figure S4 from Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma

Other · May 18, 2023 <p>Additional Kaplan-Meier survival curves based on Hyams Grade, Dulguerov T-stage, and MKI67 gene expression. Log-rank test used to determine statistical significance.</p> ... Full text Cite