Ornit Chiba-Falek

Professor in Neurology

Neurology, Translational Brain Sciences

o.chibafalek@duke.edu

Duke Box 2900, Durham, NC 27710

311 Research Drive, Bryan Research Building, Room 201A, Durham, NC 27710

More About This Person

At a Glance

Credentials
1. Education

Academic Experience
1. Current Duke Appointments & Affiliations
2. Previous Duke Appointments & Affiliations

Global Scholarship

Keywords

Research
1. Selected Grants
2. External Relationships

Scholarly Works

Teaching & Mentoring
1. Recent Courses

Recognition

Professional Activities
1. Service to Duke

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Scholarly Works - Conferences

Novel AAV vectors for allele-discriminatory-based, epigenome-editing therapy targeting ApoE4 allele in Alzheimer's Disease (AD) cases

Conference MOLECULAR THERAPY · May 8, 2026 Link to item Cite

Dopaminergic neuron-specific SNCA-targeted epigenome therapy for precision medicine in Parkinson's disease

Conference MOLECULAR THERAPY · May 8, 2026 Link to item Cite

Neuronal-Type Specific SNCA-Targeted Epigenome Therapy for Precision Medicine in Synucleinopathies

Conference MOLECULAR THERAPY · April 28, 2025 Link to item Cite

Neuronal-Type Specific SNCA-Targeted Epigenome Therapy for Precision Medicine in Synucleinopathies

Conference MOLECULAR THERAPY · April 22, 2024 Link to item Cite

A Novel, Highly Efficient EpigenomeEditing System Based on an All-in-One Adeno-Associated Vector Delivery Platform: Preclinical Proof-of-Concept and In Vivo Validation

Conference MOLECULAR THERAPY · May 1, 2023 Link to item Cite

Bimodular CRISPR/Cas-lentiviral Vector for Modeling Diseases

Conference MOLECULAR THERAPY · April 2022 Link to item Cite

APOE-Targeted Epigenome Therapy for Alzheimer's Disease

Conference MOLECULAR THERAPY · April 2022 Link to item Cite

Policies and Pitfalls: What the Alzheimer's Community Can Learn from the Deployment of Disease-Modifying Therapies for Multiple Sclerosis Patients

Conference MOLECULAR THERAPY · April 27, 2021 Link to item Cite

Downregulation of SNCA Expression as a Therapoetic Approach for Parkinson's Disease and Other Synucleinopathies: New Target Validation for Next-Generation Drug Discovery

Conference MOLECULAR THERAPY · April 27, 2021 Link to item Cite

The New Frontier in the Development of LOAD Therapies Targeting APOE

Conference MOLECULAR THERAPY · April 27, 2021 Link to item Cite

Epigenome-Base Strategies for Efficient and Safe Editing of APOEε4 Allele: Implications for Alzheimer's Disease

Conference MOLECULAR THERAPY · April 27, 2021 Link to item Cite

Using Functional SNPs to Calculate a Polygenic Risk Score for LOAD

Conference MOLECULAR THERAPY · April 27, 2021 Link to item Cite

Implications of Gene Therapy for Alzheimer's

Conference MOLECULAR THERAPY · April 28, 2020 Link to item Cite

Epigenetic Downregulation of ApoE4 for Alzheimer's Disease

Conference MOLECULAR THERAPY · April 28, 2020 Link to item Cite

Allele Specific Knockdown of APOE e4 Expression: A Novel Platform for Precision Gene Therapy in Alzheimer's Disease

Conference MOLECULAR THERAPY · April 28, 2020 Link to item Cite

Development of Lentiviral Platform for Allele-Specific Targeted Down-Regulation of APOEe4 Expression: Epigenetic Therapy for Precision Medicine in Alzheimer's Disease

Conference MOLECULAR THERAPY · April 28, 2020 Link to item Cite

An Isogenic hiPSC-Derived Model System for Establishing Gene Therapy Approaches in Alzheimer's Disease

Conference MOLECULAR THERAPY · April 28, 2020 Link to item Cite

Integrase-Deficient Lentiviral Vector for Efficient CRISPR/Cas9-Mediated Gene and Epigenome-Editing Applications

Conference MOLECULAR THERAPY · April 22, 2019 Link to item Cite

The New Epigenome-Editing Approach for Targeting Dysregulated SNCA Expression: Novel Target Validation for Next-Generation Drug Discovery

Conference MOLECULAR THERAPY · April 22, 2019 Link to item Cite

GWAS meta-analysis (N=279,930) identifies new genes and functional links to general cognitive ability

Conference HUMAN GENOMICS · March 9, 2018 Link to item Cite

A Genome-wide association study of non-pathological cognitive ageing

Conference BEHAVIOR GENETICS · November 1, 2012 Link to item Cite