Scholars@Duke
Oana Craciunescu

Oana Craciunescu

Professor of Radiation Oncology
Radiation Oncology
oana.craciunescu@duke.edu
Box 3295 Med Ctr, Durham, NC
40 Medicine Circle Duke South, Box 3295, Durham, NC 27710

Selected Publications

Commissioning of the Varian universal interstitial cylinder system for HDR brachytherapy of gynecological cancer.

Journal Article J Appl Clin Med Phys · February 2025 PURPOSE: This paper outlines the commissioning of the Varian (VMS, Varian Medical Systems, Palo Alto, CA) Universal Interstitial Cylinder (UIC) applicator set for Ir-192 HDR brachytherapy. The UIC was commissioned for use with CT and MRI and a custom phant ... Full text Link to item Cite

Evaluation of cumulative dose distributions from external beam radiation therapy using CT-to-CBCT deformable image registration (DIR) for cervical cancer patients.

Journal Article J Appl Clin Med Phys · January 2025 PURPOSE: To investigate dose differences between the planning CT (pCT) and dose calculated on pre-treatment verification CBCTs using DIR and dose summation for cervical cancer patients. METHODS: Cervical cancer patients treated at our institution with 45 G ... Full text Link to item Cite

Retrospective assessment of HDR brachytherapy dose calculation methods in locally advanced cervical cancer patients: AcurosBV vs. AAPM TG43 formalism.

Journal Article J Appl Clin Med Phys · January 2025 PURPOSE: This retrospective analysis was completed to investigate the use of a model-based dose calculation algorithm (MBDCA) AcurosBV, for use in HDR BT treatments for locally advanced cervical cancer treated with tandem and ovoid applicators with interst ... Full text Link to item Cite

A novel multi-modality imaging phantom for validating interstitial needle guidance for high dose rate gynecological brachytherapy.

Journal Article J Appl Clin Med Phys · October 2023 PURPOSE: To design, manufacture, and validate a female pelvic phantom for multi-modality imaging (CT, MRI, US) to benchmark a commercial needle tracking system with application in HDR gynecological (GYN) interstitial procedures. MATERIALS AND METHODS: A GY ... Full text Open Access Link to item Cite

Transitioning from a COMS-based plaque brachytherapy program to using eye physics plaques and plaque simulator treatment planning system: A single institutional experience.

Journal Article J Appl Clin Med Phys · May 2023 The aim of this work is to describe the implementation and commissioning of a plaque brachytherapy program using Eye Physics eye plaques and Plaque Simulator treatment planning system based on the experience of one institution with an established COMS-base ... Full text Link to item Cite

What is appropriate target delineation for MRI-based brachytherapy for medically inoperable endometrial cancer?

Journal Article Brachytherapy · 2023 PURPOSE: For medically inoperable endometrial cancer (MIEC), the volumetric target of image-guided brachytherapy (IGBT) techniques is not well established. We propose a high-risk CTV (HRCTV) concept and report associated rates of local control and toxicity ... Full text Link to item Cite

Adaptive Positron Emission Tomography Radiation Therapy in Patients With Locally Advanced Vulvar Cancer: A Prospective Study.

Journal Article Adv Radiat Oncol · 2023 PURPOSE: In this prospective trial, we aim to determine whether fluorodeoxyglucose positron emission tomography and computed tomography (PET/CT)-based adaptive radiation therapy (ART) improves dosimetry outcomes for patients treated with definitive radiati ... Full text Link to item Cite

Real -Time Precision Needle Tracking for Gynecological Interstitial Brachytherapy: A Phantom Feasibility Study

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2023 Cite

Dual-source strength seed loading for eye plaque brachytherapy using eye physics eye plaques: A feasibility study.

Journal Article J Contemp Brachytherapy · December 2022 PURPOSE: This study quantifies the dosimetric impact of incorporating two iodine-125 (125I) seed source strengths in Eye Physics eye plaques for treatment of uveal melanoma. MATERIAL AND METHODS: Plaque Simulator was used to retrospectively plan 15 clinica ... Full text Open Access Link to item Cite

Preliminary Results of Uveal Melanoma Treated With Iodine-125 Plaques: Analysis of Disease Control and Visual Outcomes With 63 Gy to the Target Volume.

Journal Article Advances in radiation oncology · March 2022 PurposeOur purpose was to review the preliminary outcomes of patients with uveal melanoma treated with iodine-125 plaques using a novel treatment planning approach.Methods and materialsThis was a single institution, retrospective r ... Full text Cite

Adaptive PET Radiation Therapy in Patients with Locally Advanced Vulvar Cancer: A Prospective Study

Conference INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · 2022 Cite

Evaluation of eddy current distortion and field inhomogeneity distortion corrections in MR diffusion imaging using log-demons DIR method.

Journal Article Phys Med Biol · January 29, 2021 To investigate the feasibility of the log-demons deformable image registration (DIR) method to correct eddy current and field inhomogeneity distortions while preserving diffusion tensor information. Diffusion-weighted images (DWIs) are susceptible to disto ... Full text Link to item Cite

Recumbent Total Skin Electron Beam Therapy.

Journal Article Adv Radiat Oncol · 2021 PURPOSE: Our purpose was to describe preliminary dosimetric and clinical results of a recumbent total skin electron beam therapy (TSEBT) technique and compare this to a conventional standing TSEBT technique. METHODS AND MATERIALS: A customized treatment pl ... Full text Link to item Cite

Establishing ADC-Based Histogram and Texture Features for Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma.

Journal Article Frontiers in oncology · January 2021 The purpose of this study was to assess baseline variability in histogram and texture features derived from apparent diffusion coefficient (ADC) maps from diffusion-weighted MRI (DW-MRI) examinations and to identify early treatment-induced changes to these ... Full text Cite

Multi-material 3D Printing in Brachytherapy– Prototyping Teaching Tools

Conference International Journal of Radiation Oncology*Biology*Physics · November 2020 Full text Cite

A design process for a 3D printed patient-specific applicator for HDR brachytherapy of the orbit.

Journal Article 3D Print Med · June 29, 2020 BACKGROUND: This report describes a process for designing a 3D printed patient-specific applicator for HDR brachytherapy of the orbit. CASE PRESENTATION: A 34-year-old man with recurrent melanoma of the orbit was referred for consideration of re-irradiatio ... Full text Link to item Cite

Multimaterial three-dimensional printing in brachytherapy: Prototyping teaching tools for interstitial and intracavitary procedures in cervical cancers.

Journal Article Brachytherapy · 2020 PURPOSE: As the utilization of brachytherapy procedures continues to decline in clinics, a need for accessible training tools is required to help bridge the gap between resident comfort in brachytherapy training and clinical practice. To improve the qualit ... Full text Link to item Cite

Changes on Midchemoradiation Therapy Fluorodeoxyglucose Positron Emission Tomography for Cervical Cancer Are Associated with Prognosis.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2019 PURPOSE: To assess whether radiographic and metabolic changes on midchemoradiation therapy (CRT) fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) for cervical cancer predict outcome. METHODS AND MATERIALS: Women with Int ... Full text Link to item Cite

Commissioning and Clinical Implementation of a Laying Down Technique for Total Skin Irradiation

Conference International Journal of Radiation Oncology*Biology*Physics · November 2018 Full text Cite

Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma.

Journal Article N Engl J Med · January 4, 2018 BACKGROUND: Despite current therapies, diffuse cutaneous systemic sclerosis (scleroderma) often has a devastating outcome. We compared myeloablative CD34+ selected autologous hematopoietic stem-cell transplantation with immunosuppression by means of 12 mon ... Full text Link to item Cite

Real-time dose-rate monitoring with gynecologic brachytherapy: Results of an initial clinical trial.

Journal Article Brachytherapy · 2018 PURPOSE: A nanoscintillator-based fiber-optic dosimeter (nanoFOD) was developed to measure real-time dose rate during high-dose-rate (HDR) brachytherapy. A trial was designed to prospectively test clinical feasibility in gynecologic implants. METHODS AND M ... Full text Link to item Cite

Simultaneous Integrated Parametrial/Sidewall Boosts for Cervical Cancer: Late Toxicity and Outcomes.

Conference International Journal of Radiation Oncology*Biology*Physics · October 2017 Full text Cite

Radiation detection and dosimetry using Y2O3:Eu/Li nanoscintillators

Conference ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 20, 2017 Link to item Cite

HDR Brachytherapy: Treatment Verification Methods

Conference MEDICAL PHYSICS · June 1, 2017 Link to item Cite

Vaginal Toxicity From Vaginal Brachytherapy and Capri-Based Systems.

Journal Article Int J Radiat Oncol Biol Phys · October 1, 2016 Full text Link to item Cite

Real Time Dosimetry for Gynecologic Brachytherapy: Initial Results of a Prospective Clinical Trial (vol 93, pg S203, 2015)

Journal Article INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS · June 1, 2016 Link to item Cite

SU-G-201-13: Investigation of Dose Variation Induced by HDR Ir-192 Source Global Shift Within the Varian Ring Applicator Using Monte Carlo Methods.

Journal Article Med Phys · June 2016 PURPOSE: The Varian tandem and ring applicators are used to deliver HDR Ir-192 brachytherapy for cervical cancer. The source path within the ring is hard to predict due to the larger interior ring lumen. Some studies showed the source could be several mill ... Full text Link to item Cite

SU-F-R-15: Establishing Relevant ADC-Based Texture Analysis Metrics for Quantifying Early Treatment-Induced Changes in Head and Neck Squamous Cell Carcinoma.

Journal Article Med Phys · June 2016 PURPOSE: The purpose of this study is to identify texture analysis metrics from apparent diffusion coefficient (ADC) maps that would provide quantifiable changes with treatment in patients with head and neck squamous cell carcinoma (HNSCC). We discerned wh ... Full text Link to item Cite

WE-DE-201-07: Measurement of Real-Time Dose for Tandem and Ovoid Brachytherapy Procedures Using a High Precision Optical Fiber Radiation Detector.

Journal Article Med Phys · June 2016 PURPOSE: Development of a novel on-line dosimetry tool is needed to move toward patient-specific quality assurance measurements for Ir-192 HDR brachytherapy to verify accurate dose delivery to the intended location. This work describes the development and ... Full text Link to item Cite

TU-FG-202-01: Modern Intracavitary GYN Brachytherapy.

Journal Article Med Phys · June 2016 The greater use of magnetic resonance imaging (MR) in brachytherapy, for both image based planning and image guided procedures, presents a number of challenges for the physicist involved. MR is widely acknowledged as the imaging modality of choice to appre ... Full text Link to item Cite

Vaginal Dose Is Associated With Toxicity in Image Guided Tandem Ring or Ovoid-Based Brachytherapy.

Journal Article Int J Radiat Oncol Biol Phys · April 1, 2016 PURPOSE: To calculate vaginal doses during image guided brachytherapy with volume-based metrics and correlate with long-term vaginal toxicity. METHODS AND MATERIALS: In this institutional review board-approved study, institutional databases were searched t ... Full text Link to item Cite

Radiation Therapy for Cutaneous T-Cell Lymphomas.

Journal Article Dermatol Clin · October 2015 Radiation therapy is an extraordinarily effective skin-directed therapy for cutaneous T-cell lymphomas. Lymphocytes are extremely sensitive to radiation and a complete response is generally achieved even with low doses. Radiation therapy has several import ... Full text Link to item Cite

Genomic profiling in locally advanced and inflammatory breast cancer and its link to DCE-MRI and overall survival.

Journal Article Int J Hyperthermia · June 2015 PURPOSE: We have previously reported that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) perfusion patterns obtained from locally advanced breast cancer (LABC) patients prior to neoadjuvant therapy predicted pathologic clinical response. Ge ... Full text Link to item Cite

SU-E-J-262: Variability in Texture Analysis of Gynecological Tumors in the Context of An 18F-FDG PET Adaptive Protocol.

Journal Article Med Phys · June 2015 PURPOSE: This study examines the effect on texture analysis due to variable reconstruction of PET images in the context of an adaptive FDG PET protocol for node positive gynecologic cancer patients. By measuring variability in texture features from baselin ... Full text Link to item Cite

SU-E-J-249: Characterization of Gynecological Tumor Heterogeneity Using Texture Analysis in the Context of An 18F-FDG PET Adaptive Protocol.

Journal Article Med Phys · June 2015 PURPOSE: We propose a method to examine gynecological tumor heterogeneity using texture analysis in the context of an adaptive PET protocol in order to establish if texture metrics from baseline PET-CT predict tumor response better than SUV metrics alone a ... Full text Link to item Cite

SU-E-J-105: Trusting Dose Deformation and Accumulation for GYN Brachytherapy.

Journal Article Med Phys · June 2015 PURPOSE: In brachytherapy, structures surrounding the target have the potential to move between treatments and receive unknown dose. Deformable image registration could overcome challenges through dose accumulation. This study uses two possible deformable ... Full text Link to item Cite

Hyperthermia

Chapter · January 1, 2015 Full text Cite

Methods, safety, and early clinical outcomes of dose escalation using simultaneous integrated and sequential boosts in patients with locally advanced gynecologic malignancies.

Journal Article Gynecol Oncol · November 2014 OBJECTIVE: To evaluate the safety of dose escalated radiotherapy using a simultaneous integrated boost technique in patients with locally advanced gynecological malignancies. METHODS: Thirty-nine women with locally advanced gynecological malignancies were ... Full text Link to item Cite

Diffusion-weighted imaging for head and neck squamous cell carcinoma: quantifying repeatability to understand early treatment-induced change.

Journal Article AJR Am J Roentgenol · November 2014 OBJECTIVE: The purpose of this study was to define baseline variability of apparent diffusion coefficient (ADC) on diffusion-weighted MR imaging (DWI) in patients with head and neck squamous cell carcinoma (HNSCC) and to compare it with early treatment-ind ... Full text Link to item Cite

Simultaneous Integrated Boost to Pelvic and Para-Aortic Nodes From Cervical Cancer Improves the Dosimetric Therapeutic Ratio

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

A Prospective Evaluation of FDG PET Adapted IMRT for Node-Positive Gynecologic Cancers

Conference International Journal of Radiation Oncology*Biology*Physics · September 2014 Full text Cite

Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer.

Journal Article Int J Hyperthermia · August 2014 PURPOSE: Unresectable chest wall recurrences of breast cancer (CWR) in heavily pretreated patients are especially difficult to treat. We hypothesised that thermally enhanced drug delivery using low temperature liposomal doxorubicin (LTLD), given with mild ... Full text Link to item Cite

An investigation of a PRESAGE® in vivo dosimeter for brachytherapy.

Journal Article Phys Med Biol · July 21, 2014 Determining accurate in vivo dosimetry in brachytherapy treatment with high dose gradients is challenging. Here we introduce, investigate, and characterize a novel in vivo dosimeter and readout technique with the potential to address this problem. A cylind ... Full text Link to item Cite

Comprehensive population-averaged arterial input function for dynamic contrast-enhanced vmagnetic resonance imaging of head and neck cancer.

Journal Article Int J Radiat Oncol Biol Phys · July 1, 2014 PURPOSE: To generate a population-averaged arterial input function (PA-AIF) for quantitative analysis of dynamic contrast-enhanced MRI data in head and neck cancer patients. METHODS AND MATERIALS: Twenty patients underwent dynamic contrast-enhanced MRI dur ... Full text Link to item Cite

TU-C-17A-11: Progressive Knowledge Modeling for Pelvic IMRT/VMAT Treatment Planning.

Journal Article Med Phys · June 2014 PURPOSE: To investigate the feasibility of progressive knowledge modeling for IMRT/VMAT treatment planning for multiple cancer types in the pelvic region. METHODS: The treatment planning knowledge model quantifies correlations between patient anatomical fe ... Full text Link to item Cite

WE-F-BRD-01: HDR Brachytherapy II: Integrating Imaging with HDR.

Journal Article Med Phys · June 2014 In recent years, with the advent of high/pulsed dose rate afterloading technology, advanced treatment planning systems, CT/MRI compatible applicators, and advanced imaging platforms, image-guided adaptive brachytherapy treatments (IGABT) have started to pl ... Full text Link to item Cite

SU-E-J-124: FDG PET Metrics Analysis in the Context of An Adaptive PET Protocol for Node Positive Gynecologic Cancer Patients.

Journal Article Med Phys · June 2014 PURPOSE: To compare PET extracted metrics and investigate the role of a gradient-based PET segmentation tool, PET Edge (MIM Software Inc., Cleveland, OH), in the context of an adaptive PET protocol for node positive gynecologic cancer patients. METHODS: An ... Full text Link to item Cite

A pilot clinical trial of intravesical mitomycin-C and external deep pelvic hyperthermia for non-muscle-invasive bladder cancer.

Journal Article Int J Hyperthermia · May 2014 PURPOSE: This paper aims to evaluate the safety and heating efficiency of external deep pelvic hyperthermia combined with intravesical mitomycin C (MMC) as a novel therapy for non-muscle-invasive bladder cancer (NMIBC). MATERIALS AND METHODS: We enrolled s ... Full text Link to item Cite

Thermal dosimetry characteristics of deep regional heating of non-muscle invasive bladder cancer.

Journal Article Int J Hyperthermia · May 2014 PURPOSE: The aim of this paper is to report thermal dosimetry characteristics of external deep regional pelvic hyperthermia combined with intravesical mitomycin C (MMC) for treating bladder cancer following transurethral resection of bladder tumour, and to ... Full text Link to item Cite

Body mass index, dose to organs at risk during vaginal brachytherapy, and the role of three-dimensional CT-based treatment planning.

Journal Article Brachytherapy · 2014 PURPOSE: To assess the effect of body mass index (BMI) on dose to organs at risk (OARs) during high-dose-rate vaginal brachytherapy and evaluate the role of three-dimensional dose evaluation during treatment planning. METHODS AND MATERIALS: Three-dimension ... Full text Link to item Cite

Preparation and characterization of a collagen-liposome-chondroitin sulfate matrix with potential application for inflammatory disorders treatment

Journal Article Journal of Nanomaterials · January 1, 2014 Smart drug delivery systems with controllable properties play an important role in targeted therapy and tissue regeneration. The aim of our study was the preparation and in vitro evaluation of a collagen (Col) matrix embedding a liposomal formulation of ch ... Full text Cite

An imaging study to assess displacement between brachytherapy applicator and chestwall during simultaneous thermobrachytherapy of cancer

Journal Article 2013 IEEE 2nd International Conference on Image Information Processing, IEEE ICIIP 2013 · December 1, 2013 A conformal surface applicator was developed for simultaneous radiation and hyperthermia treatment of superficial cancer. A preclinical volunteer study was carried out to assess the displacement between the high dose rate (HDR) brachytherapy applicator and ... Full text Cite

Vaginal Dose and Toxicity With Image-Guided Brachytherapy

Conference International Journal of Radiation Oncology*Biology*Physics · October 2013 Full text Cite

Concurrent stereotactic radiosurgery and bevacizumab in recurrent malignant gliomas: a prospective trial.

Journal Article Int J Radiat Oncol Biol Phys · August 1, 2013 Featured Publication PURPOSE: Virtually all patients with malignant glioma (MG) eventually recur. This study evaluates the safety of concurrent stereotactic radiosurgery (SRS) and bevacizumab (BVZ), an antiangiogenic agent, in treatment of recurrent MG. METHODS AND MATERIALS: ... Full text Link to item Cite

SU-D-108-03: Evaluation of the Feasibility of a Novel Radiochromic Dosimetry System for In-Vivo Dose Verification in Organs at Risk in HDR Intracavitary Gynecological Brachytherapy.

Journal Article Med Phys · June 2013 PURPOSE: To evaluate the feasibility of a novel radiochromic dosimetry system for in-vivo dose verification in organs at risk in HDR intracavitary gynecological brachytherapy. METHODS: Novel, small cylindrical PRESAGE dosimeters (4mm in diameter by 20mm in ... Full text Link to item Cite

TH-D-108-01: Implementing MR-Guided Adaptive Brachytherapy for Cervical Cancer.

Journal Article Med Phys · June 2013 Image-guidance plays an important role in modern radiation therapy, predominantly in external beam planning and delivery. In recent years, with the advent of high/pulsed dose rate afterloading technology, advanced treatment planning systems, and CT and MRI ... Full text Link to item Cite

SU‐E‐J‐88: Dose Summation Between Multimodality Treatments for Cervical Cancer

Journal Article Medical Physics · January 1, 2013 Purpose: 1) To explore the feasibility of volumetric dose summation between external beam radiation (EBRT) and high dose rate (HDR) brachytherapy treatments for cervical cancer, and 2) to investigate the differences between two deformable registration plat ... Full text Cite

Towards comprehensive characterization of Cs-137 Seeds using PRESAGE® dosimetry with optical tomography.

Conference J Phys Conf Ser · 2013 We describe a method to directly measure the radial dose and anisotropy functions of brachytherapy sources using polyurethane based dosimeters read out with optical CT. We measured the radial dose and anisotropy functions for a Cs-137 source using a PRESAG ... Full text Link to item Cite

Quantifying Temporal Fluctuations of DCE-MRI Extracted Parameters in Neck Nodal Metastases

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Multicatheter Vaginal Balloon Brachytherapy: One Year's Clinical Experience

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Urinary Catheterization Increases the Dose to Bowel During Vaginal Brachytherapy

Conference International Journal of Radiation Oncology*Biology*Physics · November 2012 Full text Cite

Preclinical assessment of comfort and secure fit of thermobrachytherapy surface applicator (TBSA) on volunteer subjects.

Journal Article J Appl Clin Med Phys · September 6, 2012 Featured Publication A thermobrachytherapy surface applicator (TBSA) was developed for simultaneous heat and brachytherapy treatment of chest wall (CW) recurrence of breast cancer. The ability to comfortably secure the applicator over the upper torso relative to the CW target ... Full text Link to item Cite

Commissioning a CT-compatible LDR tandem and ovoid applicator using Monte Carlo calculation and 3D dosimetry.

Journal Article Med Phys · July 2012 Featured Publication PURPOSE: To determine the geometric and dose attenuation characteristics of a new commercially available CT-compatible LDR tandem and ovoid (T&O) applicator using Monte Carlo calculation and 3D dosimetry. METHODS: For geometric characterization, we quantif ... Full text Link to item Cite

TU-E-213CD-01: Image Guided Adaptive Brachytherapy for Cervical Cancer.

Journal Article Med Phys · June 2012 UNLABELLED: Image-guidance plays an important role in modern radiation therapy, predominantly in external beam planning and delivery. In contrast, brachytherapy is still largely based on systems originally developed in the early 20th century. In recent yea ... Full text Link to item Cite

SU-D-213AB-05: Commissioning a CT Compatible LDR T&O Applicator Using Analytical Calculation with ID and 3D Dosimetry.

Journal Article Med Phys · June 2012 PURPOSE: To determine the characteristics of a new commercially available CT-compatible LDR Tandem and Ovoid (T&O) applicator using 3D dosimetry. METHODS: We characterized source attenuation through the asymmetric gold shielding in the buckets by measuring ... Full text Link to item Cite

SU-D-BRB-06: Comprehensive Population-Averaged Arterial Input Function (AIF) for DCE-MRI of Head and Neck Cancer.

Journal Article Med Phys · June 2012 PURPOSE: To generate a composite population-averaged(PA)-AIF for quantitative analysis of DCE-MRI data in head and neck (H&N) patients that is based on the right (RT) and left (LT) carotids, two pre-treatment scans, and one post-treatment scan. METHODS: Tw ... Full text Link to item Cite

A heterogeneous human tissue mimicking phantom for RF heating and MRI thermal monitoring verification.

Journal Article Phys Med Biol · April 7, 2012 Featured Publication This paper describes a heterogeneous phantom that mimics a human thigh with a deep-seated tumor, for the purpose of studying the performance of radiofrequency (RF) heating equipment and non-invasive temperature monitoring with magnetic resonance imaging (M ... Full text Link to item Cite

Utility of treatment planning for thermochemotherapy treatment of nonmuscle invasive bladder carcinoma.

Journal Article Med Phys · March 2012 Featured Publication PURPOSE: A recently completed Phase I clinical trial combined concurrent Mitomycin-C chemotherapy with deep regional heating using BSD-2000 Sigma-Ellipse applicator (BSD Corporation, Salt Lake City, UT, U.S.A.) for the treatment of nonmuscle invasive bladd ... Full text Link to item Cite

Prospective trial of synchronous bevacizumab, erlotinib, and concurrent chemoradiation in locally advanced head and neck cancer.

Journal Article Clin Cancer Res · March 1, 2012 Featured Publication PURPOSE: We assessed the safety and efficacy of synchronous VEGF and epidermal growth factor receptor (EGFR) blockade with concurrent chemoradiation (CRT) in locally advanced head and neck cancer (HNC). EXPERIMENTAL DESIGN: Newly diagnosed patients with st ... Full text Link to item Cite

Dynamic contrast-enhanced MRI in head-and-neck cancer: the impact of region of interest selection on the intra- and interpatient variability of pharmacokinetic parameters.

Journal Article Int J Radiat Oncol Biol Phys · March 1, 2012 Featured Publication PURPOSE: Dynamic contrast-enhanced (DCE) MRI-extracted parameters measure tumor microvascular physiology and are usually calculated from an intratumor region of interest (ROI). Optimal ROI delineation is not established. The valid clinical use of DCE-MRI r ... Full text Link to item Cite

Hyperthermia

Chapter · January 1, 2012 Full text Cite

Commissioning of Varian ring & tandem HDR applicators: reproducibility and interobserver variability of dwell position offsets.

Journal Article J Appl Clin Med Phys · November 15, 2011 Featured Publication Studies have shown that source dwells within Varian's HDR CT/MR compatible ring applicators can deviate from intended positions by several millimeters. Quantifying this offset is an important part of commissioning. The aims of this study were to: 1) determ ... Full text Link to item Cite

Severe pulmonary toxicity after myeloablative conditioning using total body irradiation: an assessment of risk factors.

Journal Article Int J Radiat Oncol Biol Phys · November 1, 2011 Featured Publication PURPOSE: To assess factors associated with severe pulmonary toxicity after myeloablative conditioning using total body irradiation (TBI) followed by allogeneic stem cell transplantation. METHODS AND MATERIALS: A total of 101 adult patients who underwent TB ... Full text Link to item Cite

The Use of Serial FDG-PET Scanning to Develop Metabolic Response Criteria to Chemoradiation in Head and Neck Cancer (HNC)

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Evaluating Recurrent Gliomas with Diffusion-weighted MR Imaging Before and After Concurrent Radiosurgery and Bevacizumab

Journal Article International Journal of Radiation Oncology*Biology*Physics · October 2011 Full text Cite

Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: cyclophosphamide or transplantation trial.

Journal Article Int J Radiat Oncol Biol Phys · March 15, 2011 Featured Publication PURPOSE: To describe renal shielding techniques and dosimetry in delivering total body irradiation (TBI) to patients with severe systemic sclerosis (SSc) enrolled in a hematopoietic stem cell transplant protocol. METHODS AND MATERIALS: The Scleroderma: Cyc ... Full text Link to item Cite

Hyperthermia

Chapter · January 1, 2011 Full text Cite

Improved hyperthermia treatment control using SAR/temperature simulation and PRFS magnetic resonance thermal imaging.

Journal Article Int J Hyperthermia · 2011 Featured Publication PURPOSE: This article explores the feasibility of using coupled electromagnetic and thermodynamic simulations to improve planning and control of hyperthermia treatments for cancer. The study investigates the usefulness of preplanning to improve heat locali ... Full text Link to item Cite

Commissioning of Varian ring & tandem HDR applicators: Reproducibility and interobserver variability of dwell position offsets

Journal Article Journal of Applied Clinical Medical Physics · January 1, 2011 Featured Publication Studies have shown that source dwells within Varian's HDR CT/MR compatible ring applicators can deviate from intended positions by several millimeters. Quantifying this offset is an important part of commissioning. The aims of this study were to: 1) determ ... Full text Cite

On the Feasibility of Verification of 3D Dosimetry Near Brachytherapy Sources Using PRESAGE/Optical-CT.

Journal Article J Phys Conf Ser · December 7, 2010 Featured Publication PURPOSE: The feasibility of using the PRESAGE/Optical-CT system for 3D dosimetry verification around a brachytherapy source is investigated. METHOD AND MATERIALS: Brachytherapy dose distributions were obtained by irradiation of cylindrical PRESAGE volumes ... Full text Link to item Cite

Structural analysis of some soluble elastins by means of FT-IR and 2D IR correlation spectroscopy.

Journal Article Biopolymers · December 2010 Fourier transform infrared (FT-IR) spectroscopy combined with 2D correlation spectroscopy has been used to offer some information about stability and structure of some soluble elastins. Temperature has been chosen as the perturbation to monitor the infrare ... Full text Link to item Cite

Dynamic contrast enhanced-MRI in head and neck cancer patients: Variability of the precontrast longitudinal relaxation time (T10).

Journal Article Med Phys · June 2010 Featured Publication PURPOSE: Calculation of the precontrast longitudinal relaxation times (T10) is an integral part of the Tofts-based pharmacokinetic (PK) analysis of dynamic contrast enhanced-magnetic resonance images. The purpose of this study was to investigate the interp ... Full text Link to item Cite

Thermal characteristics of thermobrachytherapy surface applicators for treating chest wall recurrence.

Journal Article Phys Med Biol · April 7, 2010 Featured Publication The aim of this study was to investigate temperature and thermal dose distributions of thermobrachytherapy surface applicators (TBSAs) developed for concurrent or sequential high dose rate (HDR) brachytherapy and microwave hyperthermia treatment of chest w ... Full text Link to item Cite

SU‐GG‐T‐69: Comparison of Three Optimization Methods of BrachyVision™ for IORT Using HDR and HAM Applicator

Conference Medical Physics · January 1, 2010 Purpose: To compare the three optimization methods in BrachyVision™ (Varian Medical Systems, Palo Alto, CA) for flat surface implants using the HAM applicator; To study the effect of curvature of a surface implant on dosimetry. Method and Materials: Flat s ... Full text Cite

SU‐GG‐T‐58: Commissioning of Varian Ring & Tandem HDR Applicators: Reproducibility and Inter‐Observer Variability of Dwell Position Offsets

Conference Medical Physics · January 1, 2010 Purpose: Studies have shown that dwells within Varian HDR ring applicators can deviate from intended positions by several millimeters. Quantifying this offset is an important part of commissioning. The aims of this study were to 1) determine the reproducib ... Full text Cite

Conformal microwave array (CMA) applicators for hyperthermia of diffuse chest wall recurrence.

Journal Article Int J Hyperthermia · 2010 Featured Publication PURPOSE: This article summarises the evolution of microwave array applicators for heating large area chest wall disease as an adjuvant to external beam radiation, systemic chemotherapy, and potentially simultaneous brachytherapy. METHODS: Current devices u ... Full text Link to item Cite

Hyperthermia for locally advanced breast cancer.

Journal Article Int J Hyperthermia · 2010 Hyperthermia (HT) has a proven benefit for treating superficial malignancies, particularly chest wall recurrences of breast cancer. There has been less research utilising HT in patients with locally advanced breast cancer (LABC), but available data are pro ... Full text Link to item Cite

A phase I/II study of neoadjuvant liposomal doxorubicin, paclitaxel, and hyperthermia in locally advanced breast cancer.

Journal Article Int J Hyperthermia · 2010 Featured Publication PURPOSE: The prognosis for locally advanced breast cancer (LABC) patients continues to be poor, with an estimated five-year survival of only 50-60%. Preclinical data demonstrates enhanced therapeutic efficacy with liposomal encapsulation of doxorubicin com ... Full text Link to item Cite

Hyperthermia combined with radiation therapy for superficial breast cancer and chest wall recurrence: a review of the randomised data.

Journal Article Int J Hyperthermia · 2010 Hyperthermia has long been used in combination with radiation for the treatment of superficial malignancies, in part due to its radiosensitising capabilities. Patients who suffer superficial recurrences of breast cancer, be it in their chest wall following ... Full text Link to item Cite

Magnetic resonance imaging: a potential tool in assessing the addition of hyperthermia to neoadjuvant therapy in patients with locally advanced breast cancer.

Journal Article Int J Hyperthermia · 2010 Featured Publication The poor overall survival for patients with locally advanced breast cancers has led over the past decade to the introduction of numerous neoadjuvant combined therapy regimens to down-stage the disease before surgery. At the same time, more evidence suggest ... Full text Link to item Cite

Collagen-chondroitin sulfate-hydroxyapatite porous composites: preparation, characterization and in vitro biocompatibility testing

Journal Article Romanian Biotechnological Letters · November 17, 2009 The aim of this study was to develop two new variants of porous composites based on collagen-chondroitin sulfate-hydroxyapatite (COL-CS-HA) mixtures. Electron microscopy examination showed that the composites had a microporous structure, with HA deposits n ... Cite

Accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas.

Journal Article Med Phys · November 2009 Featured Publication PURPOSE: To establish accuracy of real time noninvasive temperature measurements using magnetic resonance thermal imaging in patients treated for high grade extremity soft tissue sarcomas. METHODS: Protocol patients with advanced extremity sarcomas were tr ... Full text Link to item Cite

Synchronous Chemoradiation and Multiple Targeted Drugs for Advanced Head and Neck Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · November 2009 Full text Cite

Dynamic contrast-enhanced magnetic resonance imaging as a predictor of clinical outcome in canine spontaneous soft tissue sarcomas treated with thermoradiotherapy.

Journal Article Clin Cancer Res · August 1, 2009 PURPOSE: This study tests whether dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters obtained from canine patients with soft tissue sarcomas, treated with hyperthermia and radiotherapy, are predictive of therapeutic outcome. EXPERIME ... Full text Link to item Cite

Real-time MRI-guided hyperthermia treatment using a fast adaptive algorithm.

Journal Article Phys Med Biol · April 7, 2009 Magnetic resonance (MR) imaging is promising for monitoring and guiding hyperthermia treatments. The goal of this work is to investigate the stability of an algorithm for online MR thermal image guided steering and focusing of heat into the target volume. ... Full text Link to item Cite

Nano-β-tricalcium phosphate/collagen materials with improved biostability for bone replacement applications

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · March 23, 2009 Three mixtures of collagen (COL) solution and nano-ß-tricalcium phosphate (n-ß-TCP) powder, with dry weight ratios of 1:1; 1:2.6 and 1:5, respectively were prepared. After freeze-drying, porous three-dimensional (3D) scaffolds were obtained. COL/ß-n-TCP sc ... Full text Cite

Clinical Utility of Magnetic Resonance Thermal Imaging (MRTI) For Realtime Guidance of Deep Hyperthermia.

Journal Article Proc SPIE Int Soc Opt Eng · February 25, 2009 A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance therma ... Full text Link to item Cite

Progress on ThermoBrachytherapy Surface Applicator for Superficial Tissue Diseases.

Journal Article Proc SPIE Int Soc Opt Eng · February 12, 2009 This work reports the ongoing development of a combination applicator for simultaneous heating of superficial tissue disease using a 915 MHz DCC (dual concentric conductor) array and High Dose Rate (HDR) brachytherapy delivered via an integrated conformal ... Full text Link to item Cite

WE‐C‐BRC‐02: Combined Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE‐MRI) and Magnetic Resonance Thermal Imaging (MRTI) for Optimal Hyperthermia Treatment of Advanced Extremity Sarcomas: Fifteen Patients Update

Conference Medical Physics · January 1, 2009 Purpose: To deliver optimal hyperthermia (HT) treatments for patients with advanced extremity sarcomas using DCE‐MRI and MRTI Method and Materials: Patients were treated on a protocol using radiotherapy consisting of 45 Gy and once a week HT for 5 weeks in ... Full text Cite

DCE-MRI parameters have potential to predict response of locally advanced breast cancer patients to neoadjuvant chemotherapy and hyperthermia: a pilot study.

Journal Article Int J Hyperthermia · 2009 Featured Publication UNLABELLED: Combined therapies represent a staple of modern medicine. For women treated with neoadjuvant chemotherapy (NA ChT) for locally advanced breast cancer (LABC), early determination of whether the patient will fail to respond can enable the use of ... Full text Link to item Cite

Shaping and resizing of multifed slot radiators used in conformal microwave antenna arrays for hyperthermia treatment of large superficial diseases.

Journal Article Int Conf Electromagn Adv Appl · 2009 It has been recently shown that chestwall recurrence of breast cancer and many other superficial diseases can be successfully treated with the combination of radiation, chemotherapy and hyperthermia. Conformal microwave antenna array for hyperthermia treat ... Full text Link to item Cite

In vitro evaluation of new topical preparation based on polyphenols, zinc and a matrix animal components

Journal Article Archives of the Balkan Medical Union · January 1, 2009 Introduction: Damaged tissue regeneration can be accelerated using natural biopolymers obtained from cellular derm, cartilages, which are used as membranes, hydrogels, sponges. These interact with tissues, inducing new cell and matrix material obtaining, i ... Cite

Preparation and characterization of bioresorbable synthetic scaffolds composed from different beta-tricalcium phosphate powders and collagen

Journal Article A Global Road Map for Ceramic Materials and Technologies: Forecasting the Future of Ceramics, International Ceramic Federation - 2nd International Congress on Ceramics, ICC 2008, Final Programme · December 1, 2008 In the present study, two variants of COL/β-TCP scaffolds (P1 and P2) were prepared and examined. Microcrystalline b-TCP powders were prepared at high temperatures by solid-state reactions, and the nano-powders were produced by a precipitation technique. T ... Cite

Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility.

Journal Article Micron · October 2008 The purpose of this study was ultrastructural characterization of liposomes-entrapped chondroitin sulphate and to prove their in vitro biocompatibility in a human dermal fibroblast culture system, in order to use liposome-entrapped chondroitin sulphate in ... Full text Link to item Cite

A Phase I/II Study of Neoadjuvant Liposomal Doxorubicin, Paclitaxel and Hyperthermia in Locally Advanced Breast Cancer

Conference International Journal of Radiation Oncology*Biology*Physics · September 2008 Full text Cite

Fast temperature optimization of multi-source hyperthermia applicators with reduced-order modeling of 'virtual sources'.

Journal Article Phys Med Biol · March 21, 2008 The goal of this work is to build the foundation for facilitating real-time magnetic resonance image guided patient treatment for heating systems with a large number of physical sources (e.g. antennas). Achieving this goal requires knowledge of how the tem ... Full text Link to item Cite

In vitro behaviour of osteoblast cells seeded into a COL/β-TCP composite scaffold

Journal Article Central European Journal of Biology · March 1, 2008 The purpose of the present study was to investigate the effect of a collagen/β-tricalcium phosphate (COL/β-TCP) composite on osteoblast growth and proliferation. The COL/β-TCP composite was prepared by mixing COL type I with β-TCP, in 1:1 (w/w) ratio and c ... Full text Cite

SU‐GG‐J‐181: The Role of Voxel‐Based T10 Calculations in Determining Correct Pharmacokinetic Parameters for Head and Neck Tumors

Conference Medical Physics · January 1, 2008 Purpose: To determine the optimal flip angle combination (oFAc) that generates voxel‐based T10 values, the median T10 for primary and nodes [formula omitted], and its implications on vascular permeability (PERM) and extracellular volume fraction (EVF) in H ... Full text Cite

SU‐EE‐A4‐04: Accelerating Breast Dynamic Contrast Enhanced MRI with Efficient Multiple Acquisitions by SPEED Using Shared Information

Conference Medical Physics · January 1, 2008 Purpose: The efficient multiple acquisition method using Skipped Phase Encoding and Edge Deghosting (SPEED) has been successfully demonstrated with a dynamic contrast enhanced (CE) mice tumor study; however, it has not been tested with any human subjects. ... Full text Cite

SU‐GG‐T‐367: Fast Hyperthermia Temperature Optimization for Pelvic Carcinoma Patient Treated in Sigma‐Eye Applicator

Conference Medical Physics · January 1, 2008 Purpose: Though hyperthermia shows promising features being used with radiation and chemotherapy, it requires accurate spatial power focusing, which leads a workload proportional to square of number of antennas in an applicator. This motivates this investi ... Full text Cite

The purification, physico-chemical characterization and bioactivity of polysaccharides from Viscum album

Journal Article Revista de Chimie · January 1, 2008 The aim of this paper was the isolation and purification of medical interest polysaccharides from the European mistletoe (Viscum album L.) and their chemical and biological characterization in view of the usefulness for the regeneration of dermal tissue wo ... Full text Cite

Preparation and characterization of new biocompatibilizecd polymeric materials for medical use

Journal Article Journal of Optoelectronics and Advanced Materials · January 1, 2008 The aim of this study was to prepare 4 new composite biomaterials based on polyurethane (PU) blended with different mixtures of collagen (COL), elastin (EL) and glycosaminoglycans (GAG). Bioactivated polymeric materials were structurally characterized by l ... Cite

Polyurethane-based materials covered with natural polymers for medical applications

Journal Article Materiale Plastice · January 1, 2008 Two new polymeric materials were prepared by coating of polyurethane (PU) with a collagen (COL) gel and a mixture of collagen-elastin (COL/EL). The bioactivated polymeric materials were examined by scanning electron microscopy (SEM) for pore morphology. Th ... Cite

Evaluation of the radioprotective activity of new green tea-collagen materials

Journal Article Journal of Optoelectronics and Advanced Materials · January 1, 2007 The aim of this study was to compare the protective effect of a green tea (Camellia sinensis) extract (GTE) and mixtures of GTE with collagen (COL) (GTE-COL I-V) against ultraviolet (UV) radiation using a primary culture of human dermal fibroblasts. Concen ... Cite

SU‐FF‐T‐98: Characterization of Buildup Effects in OneDosePlus MOSFET‐Based Dosimeters

Conference Medical Physics · January 1, 2007 Purpose: Evaluate the buildup cap used on OneDosePlus™ MOSFET dosimeters and study the field size, angular, and SSD dependency. Method and Materials: OneDosePlus (ODP) dosimeters are single use, pre‐calibrated MOSFETs used to measure entrance patient dose. ... Full text Cite

TU‐EE‐A2‐05: Challenges in Limiting Kidney Dose When Delivering Total Body Irradiation (TBI) for Patients with Severe Systemic Sclerosis (SSc)

Conference Medical Physics · January 1, 2007 Purpose: To describe challenges in limiting kidney dose when delivering TBI to SSc patients enrolled on a multicenter Phase II/III SCOT (Scleroderma Cyclophosphamide or Transplantation) protocol. Material and Methods: The SCOT protocol uses a preparative r ... Full text Cite

SU‐FF‐J‐105: Predicting Late Skin Effects Using Digital Infrared Imaging for Breast Cancer Patients Treated with Radiation

Conference Medical Physics · January 1, 2007 Purpose: Establish a methodology based on digital infrared imaging (DII) to predict skin reaction after breast irradiation using the Skin Radiosensitivity Index (SRI) derived from early skin temperature changes. Method and Materials: Five breast cancer pat ... Full text Cite

TH‐E‐M100J‐02: Potential of Dynamic Contrast Enhanced‐Magnetic Resonance Imaging (DCE‐MRI) Extracted Parameters to Estimate Treatment Response in Locally Advanced Head and Neck (LAHN) Cancer Patients

Conference Medical Physics · January 1, 2007 Purpose: To evaluate the use of DCE‐MRI to measure changes in tumor physiology in LAHN cancer patients receiving TT and cisplatin based concurrent chemoradiation (ChemoRT). Material and Methods: Eligible patients with LAHN were enrolled on an IRB approved ... Full text Cite

A clinically proven, prospective, thermal dose descriptor exists [4]

Journal Article Clinical Cancer Research · March 15, 2006 Full text Cite

A bioactive collagen-β tricalcium phosphate scaffold for tissue engineering

Journal Article Central European Journal of Biology · March 1, 2006 Collagen-phosphate composites (COL/β-TCP) are novel materials that have the potential to be used as bone analogues. The aim of our study was to develop a porous bioactive material composed of type I collagen, the main bone protein and tricalcium phosphate, ... Full text Cite

SU‐FF‐J‐125: Therapy Assessment Using a Full Time Point (fTP) Pharmacokinetic Analysis of Dynamic Contrast‐Enhanced Magnetic Resonance Imaging (DCE‐MRI): Role of Region of Interest (ROI) Selection in Three Tumor Sites

Conference Medical Physics · January 1, 2006 Background: DCE‐MRI has great potential to provide routine assessment of cancer treatment response. The contrast agent preferentially accumulates in tumors due to increased tumor vascular permeability. The MR based parameters that can be used for treatment ... Full text Cite

SU‐DD‐A4‐01: Quantifying Skin Effects After Accelerated Partial Breast Irradiation Using Digital Infrared Imaging (DII): Preliminary Feasibility Data

Conference Medical Physics · January 1, 2006 Purpose: Accelerated partial‐breast irradiation (APBI) is an emerging radiation technique that challenges standard whole breast irradiation. The larger fraction sizes used in these hypofractionated schedules may increase the risk of late normal tissue effe ... Full text Cite

Improved magnetic resonance thermal imaging by combining proton resonance frequency shift (PRFS) and apparent diffusion coefficient (ADC) data.

Journal Article Int J Hyperthermia · November 2005 Featured Publication Effective thermal therapy for cancer is dependent on adequate tumor heating. Adequate heating, in turn, is dependent on reliable volumetric measurement of temperature to guide heating. Proton resonance frequency shift (PRFS) magnetic resonance imaging is f ... Full text Link to item Cite

Characterizing tumor changes during neoadjuvant treatment of locally advanced breast cancer patients (LABC) using dynamic-enhanced magnetic resonance imaging (DE-MRI)

Journal Article Proc. SPIE - Int. Soc. Opt. Eng. (USA) · 2005 At Duke University Medical Center, selective LABC patients were treated on a protocol using neoadjuvant Myocet/Paclitaxel (ChT) and HT. With the purpose of generating perfusion/permeability parametric maps and to use gadolinium (Gd) enhancement curves to s ... Full text Link to item Cite

Predicting radiotherapy-induced cardiac perfusion defects.

Journal Article Med Phys · January 2005 Featured Publication The purpose of this work is to compare the efficacy of mathematical models in predicting the occurrence of radiotherapy-induced left ventricular perfusion defects assessed using single-photon emission computed tomography (SPECT). The basis of this study is ... Full text Link to item Cite

SU‐EE‐A2‐06: Non‐Contact, Non‐Invasive Breast Thermography Has Potential to Evaluate Treatment Response in Breast Cancer Patients

Conference Medical Physics · January 1, 2005 Purpose: The purpose of the study is to determine the feasibility of using Breast Thermography (BT) to improve the evaluation of treatment response in breast cancer patients. Method and Materials: A protocol is underway at our institution that enlisted 17/ ... Full text Cite

Feasibility of optimizing the dose distribution in lung tumors using fluorine-18-fluorodeoxyglucose positron emission tomography and single photon emission computed tomography guided dose prescriptions.

Journal Article Med Phys · June 2004 Featured Publication The information provided by functional images may be used to guide radiotherapy planning by identifying regions that require higher radiation dose. In this work we investigate the dosimetric feasibility of delivering dose to lung tumors in proportion to th ... Full text Link to item Cite

Fractal reconstruction of breast perfusion before and after hyperthermia treatments

Journal Article ASME International Mechanical Engineering Congress and Exposition, Proceedings · January 1, 2002 Thermal modeling for hyperthermia breast patients can provide relevant information to better understand the temperatures achieved during treatment. However, human breast is much perfiased, making knowledge of the perfusion crucial to the accuracy of the te ... Full text Cite

Fractal reconstruction of breast perfusion before and after hyperthermia treatments

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · 2002 Cite

Discretizing large traceable vessels and using DE-MRI perfusion maps yields numerical temperature contours that match the MR noninvasive measurements.

Journal Article Med Phys · November 2001 Featured Publication The success of hyperthermia treatments is dependent on thermal dose distribution. However, the three-dimensional temperature distribution remains largely unknown. Without this knowledge, the relationship between thermal dose and outcome is noisy, and thera ... Full text Link to item Cite

Pulsatile blood flow effects on temperature distribution and heat transfer in rigid vessels.

Journal Article J Biomech Eng · October 2001 Featured Publication The effect of blood velocity pulsations on bioheat transfer is studied. A simple model of a straight rigid blood vessel with unsteady periodic flow is considered. A numerical solution that considers the fully coupled Navier-Stokes and energy equations is u ... Full text Link to item Cite

Three-dimensional tumor perfusion reconstruction using fractal interpolation functions.

Journal Article IEEE Trans Biomed Eng · April 2001 Featured Publication It has been shown that the perfusion of blood in tumor tissue can be approximated using the relative perfusion index determined from dynamic contrast-enhanced magnetic resonance imaging (DE-MRI) of the tumor blood pool. Also, it was concluded in a previous ... Full text Link to item Cite

3D numerical reconstruction of the hyperthermia induced temperature distribution in human sarcomas using DE-MRI measured tissue perfusion: validation against non-invasive MR temperature measurements.

Journal Article Int J Hyperthermia · 2001 Featured Publication Essential to the success of optimized thermal treatment during hyperthermia is accurate modelling. Advection of energy due to blood perfusion significantly affects the temperature. Without accurate estimates of the magnitude of the local tissue blood perfu ... Full text Link to item Cite

A case study of hyperthermia induced temperature computations in human sarcomas using discrete vasculature and relative perfusion maps

Journal Article American Society of Mechanical Engineers, Heat Transfer Division, (Publication) HTD · January 1, 2001 One of the most important technical aspects in clinical hyperthermia is the ability to measure and/or simulate the 3D temperature fields. Related to that, an essential part is the way in which the complex heat transfer related to vasculature is described. ... Cite

Piecewise fractal interpolation models to reconstruct the three-dimensional tumor perfusion

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 2000 Fractal interpolation functions (FIFs) were used to reconstruct the 3D tumor perfusion data from 2D slices obtained using DE-MRI, as an alternative to the classical interpolation means. Two FIFs techniques were used: the piece-wise self-affine fractal inte ... Cite

Perturbations in hyperthermia temperature distributions associated with counter-current flow: numerical simulations and empirical verification.

Journal Article IEEE Trans Biomed Eng · April 2000 Featured Publication Two numerical techniques are used to calculate the effect of large vessel counter-current flow on hyperthermic temperature distributions. One is based on the Navier-Stokes equation for steady-state flow, and the second employs a convective-type boundary co ... Full text Link to item Cite

Hyperthermia induced 3D temperature distribution in a human sarcoma with tumor perfusion reconstructed using fractal interpolation functions

Conference ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) · January 1, 2000 Essential to the success of optimized thermal treatment duringhyperthermia is accurate modeling. Advection of energy due to bloodperfusion significantly perturbs the temperature and without accurateestimates of the magnitude of the local tissue blood perfu ... Full text Cite

Three-dimensional microvascular networks fractal structure: potential for tissue characterization?

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · December 1, 1999 It has been shown that the fractal dimension of 2D microvascular networks can discriminate between normal vs. tumor tissue (Gazit et al., 1995, 1997). We have determined the fractal characteristics of five 3D microvascular networks and conclude on the corr ... Cite

Dynamic contrast-enhanced MRI and fractal characteristics of percolation clusters in two-dimensional tumor blood perfusion.

Journal Article J Biomech Eng · October 1999 Featured Publication Dynamic contrast-enhanced magnetic resonance imaging (DE-MRI) of the tumor blood pool is used to study tumor tissue perfusion. The results are then analyzed using percolation models. Percolation cluster geometry is depicted using the wash-in component of M ... Full text Link to item Cite

THREE-DIMENSIONAL MICROVASCULAR NETWORKS FRACTAL STRUCTURE: POTENTIAL FOR TISSUE CHARACTERIZATION?

Conference ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) · January 1, 1999 It has been shown that the fractal dimension of 2D microvascular networks can discriminate between normal vs. tumor tissue (Gazit et al., 1995, 1997). We have determined the fractal characteristics of five 3D microvascular networks and conclude on the corr ... Full text Cite

Experimental evaluation of the thermal properties of two tissue equivalent phantom materials.

Journal Article Int J Hyperthermia · 1999 Featured Publication Tissue equivalent radio frequency (RF) phantoms provide a means for measuring the power deposition of various hyperthermia therapy applicators. Temperature measurements made in phantoms are used to verify the accuracy of various numerical approaches for co ... Full text Link to item Cite

Towards the understanding of blood perfusion in tumor vascular networks using contrast-enhanced MRI and invasion percolation

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · December 1, 1998 Accurate knowledge of the hyperthermia induced power deposition and temperature patterns are necessary to optimize the hyperthermia dose. A critical factor influencing the hyperthermia induced temperature distribution is the tumor blood perfusion. Hence, p ... Cite

TOWARDS THE UNDERSTANDING OF BLOOD PERFUSION IN TUMOR VASCULAR NETWORKS USING CONTRAST-ENHANCED MRI AND INVASION PERCOLATION

Conference ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) · January 1, 1998 Accurate knowledge of the hyperthermia induced power deposition and temperature patterns are necessary to optimize the hyperthermia dose. A critical factor influencing the hyperthermia induced temperature distribution is the tumor blood perfusion. Hence, p ... Full text Cite

Perturbations of large vessels on induced temperature distributions. Part A: Three-dimensional simulation study

Journal Article American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · December 1, 1997 It is well known that large blood vessels perturb the induced temperature distributions in biological situations. The understanding of the magnitude of the perturbation of the temperature distribution as a function of the vessel size and temperature gradie ... Cite

PERTURBATIONS OF LARGE VESSELS ON INDUCED TEMPERATURE DISTRIBUTIONS. PART A: THREE-DIMENSIONAL SIMULATION STUDY

Conference ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE) · January 1, 1997 It is well known that large blood vessels perturb the induced temperature distributions in biological situations. The understanding of the magnitude of the perturbation of the temperature distribution as a function of the vessel size and temperature gradie ... Full text Cite

Time-dependent interaction between water at supercritical pressures and a hot surface

Journal Article Numerical Heat Transfer; Part A: Applications · January 1, 1996 This article presents a numerical study of the thermal and fluid flow interaction driven by the sudden contact between saturated liquid water (373 K) and a hot (2300 K) spherical or plane surface. It is shown that under these conditions the sudden contact ... Full text Cite

Simultaneous integrated boost (SIB) for treatment of gynecologic carcinoma: Intensity-modulated radiation therapy (IMRT) vs volumetric-modulated arc therapy (VMAT) radiotherapy.

Conference Med Dosim The aim of this study was to quantitatively compare dosimetric criteria between intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) plans for patients undergoing radiation treatment of gynecologic carcinoma with a simul ... Full text Link to item Cite