Scholars@Duke
Opeyemi Olabisi

Opeyemi Olabisi

Associate Professor of Medicine
Medicine, Nephrology

Featured Works

Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function.

Journal article J Am Soc Nephrol · September 2020 Featured Publication BACKGROUND: Two coding renal risk variants (RRVs) of the APOL1 gene (G1 and G2) are associated with large increases in CKD rates among populations of recent African descent, but the underlying molecular mechanisms are unknown. Mammalian cell culture models ... Full text Open Access Link to item Cite

APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases.

Journal article Proc Natl Acad Sci U S A · January 26, 2016 Featured Publication Two specific genetic variants of the apolipoprotein L1 (APOL1) gene are responsible for the high rate of kidney disease in people of recent African ancestry. Expression in cultured cells of these APOL1 risk variants, commonly referred to as G1 and G2, resu ... Full text Link to item Cite