Scholars@Duke
Takuya Osada

Takuya Osada

Adjunct Associate Professor in the Department of Surgery
Surgery, Surgical Sciences
osada001@mc.duke.edu
Box 2606 Med Ctr, Durham, NC 27710
401 Med Sci Res Bldg, Durham, NC 27710

Scholarly Works - Conferences

Ultrasound Enhanced Perfusion and Drug Penetration for Intratumoral Immunotherapy Using a Needle Ultrasound Transducer - a Phantom Study

Conference IEEE International Ultrasonics Symposium Ius · January 1, 2023 Intratumoral immunotherapy is a promising cancer treatment approach that can initiate durable anti-tumor responses and avoid potential off-target toxicities. However, direct intratumoral injection remains challenging owing to elevated solid stress and inte ... Full text Cite

Intracorporeal Sonoporation-Induced Drug/Gene Delivery Using a Catheter Ultrasound Transducer

Conference IEEE International Ultrasonics Symposium Ius · January 1, 2022 Ultrasound (US) has been recently demonstrated promising in cancer immunotherapy. By virtue of microbubble-mediated cavitation, US can induce temporary pores in the cell membrane to enhance drug/gene delivery and this process is termed sonoporation. Curren ... Full text Cite

Targeting the Glucagon Receptor Signaling Pathway As a Novel Strategy to Counteract PI3K Inhibitor Induced Hyperglycemia While Sustaining Tumor PI3K Inhibition

Conference Blood · November 5, 2020 Pathologic activation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway is an oncogenic driver for many malignancies, including lymphomas1. Although validated as a therapeutic oncologic target, the PI3K signaling pathway is also imp ... Full text Cite

Abstract 4071: A novel combination therapy of high intensity focused ultrasound and PDL1 blockades against advanced breast cancer

Conference Cancer Research · July 1, 2019 AbstractBackground: Previous studies have reported that tumor debris and inflammation made by high-intensity focused ultrasound (HIFU) therapy induced the antitumor immune response, however, HIFU as a monoth ... Full text Cite

Abstract 3731: A novel heat shock protein 90-targeted photosensitizer (HS-201) enables enhanced tumor-specific photodynamic therapy of inflammatory breast cancers

Conference Cancer Research · July 1, 2019 AbstractBackground: Photodynamic therapy (PDT) is an effective local anti-cancer modality applied for the treatment of early stage disease and palliation of advanced disease, and could be used in managing ... Full text Cite

Abstract P2-09-16: CD8 T cells induced by novel alphaviral vector predict improved progression free survival in advanced HER2+ breast cancer patients

Conference Cancer Research · February 15, 2019 AbstractBackground: Immune-based therapy for metastatic breast cancer has had limited success. Strategies to augment adaptive immunity include vaccines targeting genomic amplifications like Human Epidermal G ... Full text Cite

Abstract 1859: Hsp90 targeted near infrared molecular imaging to detect mammografically occult invasive lobular breast cancer

Conference Cancer Research · July 1, 2017 AbstractBackground: Early diagnosis of Invasive lobular carcinomas (ILCs) is clinically challenging due to its histopathologic features making it difficult to detect using mammography. Because of the diffuse ... Full text Cite

Abstract 4709: Induction of enhanced tumor-specific immunity by Hsp90 targeted photodynamic therapy (Hsp90-PDT) combined with immune checkpoint inhibition

Conference Cancer Research · July 1, 2017 AbstractBackground: Immunotherapy has become an emerging anti-cancer therapy, as immune checkpoint blockade with PD-1 or PD-L1 inhibition have been active against multiple cancer types. Nonetheless, there re ... Full text Cite

Abstract B36: Modulating the tumor microenvironment to enhance cancer immunotherapy by inducing phosphatidylserine expression on the tumor surface

Conference Cancer Immunology Research · March 1, 2017 AbstractBackground and Hypothesis: While immune checkpoint blockade, in particular PD-1 or PD-L1 inhibition, has revolutionized cancer immunotherapy, a significant number of patients with solid tumors fail t ... Full text Cite

Low Volume Aerobic Training Heightens Muscle Deoxygenation in Early Post-Angina Pectoris Patients.

Conference Adv Exp Med Biol · 2016 The aim of this study was to investigate the effect of low volume aerobic exercise training on muscle O2 dynamics during exercise in early post-angina pectoris (AP) patients, as a pilot study. Seven AP patients (age: 72 ± 6 years) participated in aerobic e ... Full text Link to item Cite

Muscle Deoxygenation and Its Heterogeneity Changes After Endurance Training.

Conference Adv Exp Med Biol · 2016 The purpose of this study was to elucidate the time course of muscle deoxygenation and its heterogeneity changes through endurance training. Nine healthy untrained male participated in this study. The subjects performed a ramp incremental cycle exercise pr ... Full text Link to item Cite

Muscle Oxygen Dynamics During Cycling Exercise in Angina Pectoris Patients.

Conference Adv Exp Med Biol · 2016 Muscle O2 dynamics during ramp cycling exercise were compared between angina pectoris patients (AP; n = 7, age: 73 ± 6 years) after coronary artery bypass grafting and age-, height-, and body weight-matched elderly control subjects (CON; n = 7, age: 74 ± 8 ... Full text Link to item Cite

The Effects of Passive Cycling Exercise for 20 min on Cardiorespiratory Dynamics in Healthy Men [corrected].

Conference Adv Exp Med Biol · 2016 An increase in the incidence rate of cardiovascular disease is attributed to high daily sitting time, while a drop in risk of cardiovascular disease comes from a decrease in daily sitting time, rather than an increase in physical activity levels. Although ... Full text Link to item Cite

Effects of Low Volume Aerobic Training on Muscle Desaturation During Exercise in Elderly Subjects.

Conference Adv Exp Med Biol · 2016 Aging enhances muscle desaturation responses due to reduced O2 supply. Even though aerobic training enhances muscle desaturation responses in young subjects, it is unclear whether the same is true in elderly subjects. Ten elderly women (age: 62±4 years) pa ... Full text Link to item Cite

Sex-Related Difference in Muscle Deoxygenation Responses Between Aerobic Capacity-Matched Elderly Men and Women.

Conference Adv Exp Med Biol · 2016 Muscle O2 dynamics during ramp cycling exercise were compared between aerobic capacity-matched elderly men (n=8, age 65±2 years) and women (n=8, age 66±3 years). Muscle O2 saturation (SmO2) and relative change in deoxygenated (Δdeoxy-Hb) and total hemoglob ... Full text Link to item Cite

An Anti-HER2 Nanobody Labeled with 18F Using a Residualizing Label for Assessing HER2 Status

Conference EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING · October 1, 2015 Link to item Cite

Abstract C86: Tethered Hsp90 inhibitors carrying optical or radioiodinated probes reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.

Conference Molecular Cancer Therapeutics · November 1, 2013 AbstractHsp90 inhibitors have demonstrated unusual selectivity for tumor cells despite its ubiquitous expression. This phenomenon has remained unexplained but could be influenced by ectopically expressed Hsp ... Full text Cite

Which is the best indicator of muscle oxygen extraction during exercise using NIRS?: Evidence that HHb is not the candidate.

Conference Adv Exp Med Biol · 2013 Recently, deoxygenated hemoglobin (HHb) has been used as one of the most popular indicators of muscle O2 extraction during exercise in the field of exercise physiology. However, HHb may not sufficiently represent muscle O2 extraction, as total hemoglobin ( ... Full text Link to item Cite

Aging affects spatial distribution of leg muscle oxygen saturation during ramp cycling exercise.

Conference Adv Exp Med Biol · 2013 We compared muscle oxygen saturation (SmO2) responses in several leg muscles and within a single muscle during ramp cycling exercise between elderly men (n = 8; age, 65 ± 3 years; ELD) and young men (n = 10; age, 23 ± 3 years; YNG). SmO2 was monitored at t ... Full text Link to item Cite

O2 saturation in the intercostal space during moderate and heavy constant-load exercise.

Conference Adv Exp Med Biol · 2013 To examine the hypothesis that the relationship between minute ventilation (VE) and deoxygenation from the intercostal space (IC) would be steady regardless of exercise protocols, if an increase in O2 consumption of the accessory respiratory muscles with a ... Full text Link to item Cite

Development of an assay to predict oxaliplatin sensitivity from formalin-fixed, paraffin-embedded (FFPE) colorectal cancer tissues.

Conference Journal of Clinical Oncology · February 1, 2011 429 Background: Genomic profiling has improved our understanding of the underlying biology of tumors, accuracy of diagnosing disease, predictions of the courses of disease, and ability to determine the therapeutic agents that wil ... Full text Cite

Decreased muscle oxygenation and increased arterial blood flow in the non-exercising limb during leg exercise.

Conference Adv Exp Med Biol · 2010 We evaluated arterial blood flow, muscle tissue oxygenation and muscle metabolism in the non-exercising limb during leg cycling exercise. Ten healthy male volunteers performed a graded leg cycling exercise at 0, 40, 80, 120 and 160 watts (W) for 5 min each ... Full text Link to item Cite

Unchanged muscle deoxygenation heterogeneity during bicycle exercise after 6 weeks of endurance training.

Conference Adv Exp Med Biol · 2010 The purpose of this study was to examine the changes in muscle oxygen saturation (SmO(2)) level and its heterogeneity after 6 weeks of endurance training using multi-channel near infrared spatially resolved spectroscopy (NIR(SRS)). Nine healthy subjects pa ... Full text Link to item Cite

Comparison of muscle O(2) dynamics at different sites of the forearm flexor muscles during incremental handgrip exercise.

Conference Adv Exp Med Biol · 2010 This study investigated heterogeneity of muscle O(2) consumption (diffusive m-VO(2)) and muscle oxygenation difference (m-O(2) difference) within the forearm flexor muscles using multi-optical fibers near-infrared continuous wave spectroscopy (NIRcws) duri ... Full text Link to item Cite

Effects of bicycle ergometer exercise and PGE1 injection for patients with intermittent claudication

Conference Japanese Journal of Physical Fitness and Sports Medicine · January 1, 2006 The purpose of this study was to clarify the effects of bicycle ergometer training and prostaglandin E1 (PGE1) for patients with intermittent claudication. Subjects were divided into four groups: the medication group (M), the PGE ... Full text Cite

Muscle oxygenation heterogeneity in a single muscle at rest and during bicycle exercise

Conference Japanese Journal of Physical Fitness and Sports Medicine · January 1, 2006 We evaluated regional differences of muscle O2 dynamics between distal and proximal sites in the vastus lateralis (VL) muscle using near infrared spatial resolved spectroscopy (NIRSRS). forty-one male subjects performed a 30 W ramp in ... Full text Cite

Effects of physical activity on age-related decline in oxygen delivery to working muscles

Conference Japanese Journal of Physical Fitness and Sports Medicine · January 1, 2006 The purpose of this study was to determine the age and habitual physical activity on re-oxygenation time in working muscles following maximal cycling exercise (CycEXmax). Twelve sedentary middle-aged (50±6), 13 sedentary elderly (66±3), 13 active middle-ag ... Full text Cite

Change of forearm muscle oxygen consumption in pediatrie kidney transplant patients

Conference Japanese Journal of Physical Fitness and Sports Medicine · January 1, 2006 The aim of the present study is to clarify the improvement of peripheral muscle oxygen consumption after successful renal transplantation. We investigated change of forearm (brachioradial muscle) muscular oxygen consumption in chronic renal failure childre ... Full text Cite

Quantitative Evaluation of Oxygenation and Metabolism in the Human Skeletal Muscle

Conference Optical Review · January 1, 2003 The forearm muscles of five healthy males were monitored for changes in microvessel hemoglobin saturation (SO2TRS) by near infrared time-resolved spectroscopy (NIRTRS) and changes in phosphorus metabolites by magnetic resonance spectr ... Full text Cite

Muscle reoxygenation rate after isometric exercise at various intensities in relation to muscle oxidative capacity.

Conference Adv Exp Med Biol · 2003 The purpose of this study was to determine whether the reoxygenation rate (Reoxy-rate) immediately after static exercise at various submaximal intensities would be related to muscle oxidative capacity. Seven healthy male subjects performed isometric handgr ... Full text Link to item Cite

Changes in oxygenation and phosphocreatine during exercise and recovery in relation to fiber types and capillary supply in human skeletal muscle

Conference Proceedings of SPIE the International Society for Optical Engineering · December 1, 1997 The purpose of this study was to examine the relationship between histochemical characteristics obtained from the gastrocnemius and changes in muscle energetics. Muscle oxygenation was determined by near infrared spectroscopy (NIRS), and phosphocreatine (P ... Full text Cite