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Oyindamola Adefisayo

Postdoctoral Associate
Molecular Genetics and Microbiology
270 Jones, Box 3054, Durham, NC 27710
270 Jones BX 3054, 207 Research Drive, Durham, NC 27710

Overview


B.A. Biology, Clark University

Ph.D. Immunology and Microbial Pathogenesis, Memorial Sloan Kettering Cancer Center

Oyinda was born in Lagos, Nigeria but found her way to the US from the African Leadership Academy in Johannesburg, South Africa where she completed her Cambridge A. levels.

She obtained her B.A in Biology from Clark University where she undertook diverse research experiences in order to find her greatest interest. Most of her undergraduate research experience was under the mentorship of Dr. Justin Thackeray where she focused on decoupling the genetic basis of wing and eye development in Drosophila melanogaster. Her other undergraduate research experiences include a summer research experience at the NIH under the guidance of Dr. Patrick Duffy and a marine research experience where she discovered a love for scuba diving.

Oyinda moved to NYC to pursue a Ph.D. in Immunology and Microbial Pathogenesis in the lab of Dr. Michael Glickman where she fully characterized the contributions of the DNA damage response pathways in mycobacteria to antibiotic resistance and mutagenesis. Using various molecular techniques, she was able to show a requirement for both pathways in the development of antibiotic resistance. Additionally she identified replication fork stalling as a specific activation signal for the PafBC DNA damage response pathway which is the first known indication of the regulation of this pathway.

She joined Dr. Clare Smith’s lab for her postdoctoral studies with a desire to explore the bacterial determinants of host-pathogen interactions particularly in the context of diverse host environments as exhibited by the panel of Cross Collaborative Mice.

Outside of lab work, ballroom dancing and providing hospice care for older and sick dogs remain major passions for Oyinda.

Follow her on Twitter @AdefisayoOyinda 
Contact her: oyindamola.adefisayo@duke.edu

Current Appointments & Affiliations


Recent Publications


Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis

Journal Article Nature Communications · August 2, 2022 AbstractAntibiotic resistance of Mycobacterium tuberculosis is exclusively a consequence of chromosomal mutations. Translesion synthesis (TLS) is a widely conserved mechanism of DNA damage toleran ... Full text Cite

Division of labor between SOS and PafBC in mycobacterial DNA repair and mutagenesis

Journal Article Nucleic Acids Research · December 16, 2021 AbstractDNA repair systems allow microbes to survive in diverse environments that compromise chromosomal integrity. Pathogens such as Mycobacterium tuberculosis must contend with the genotoxic host environme ... Full text Cite

Mycobacterial Mutagenesis and Drug Resistance Are Controlled by Phosphorylation- and Cardiolipin-Mediated Inhibition of the RecA Coprotease.

Journal Article Mol Cell · October 4, 2018 Infection with Mycobacterium tuberculosis continues to cause substantial human mortality, in part because of the emergence of antimicrobial resistance. Antimicrobial resistance in tuberculosis is solely the result of chromosomal mutations that modify drug ... Full text Link to item Cite
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Recent Grants


Metabolic determinants of Mtb virulence, vulnerability and variation Animal Core E

ResearchPostdoctoral Associate · Awarded by Brigham and Women's Hospital · 2021 - 2026

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