Scholars@Duke

• Recognition
• 

  Awards & Honors

  • Robert J. Fitzgerald Scholar. Pharmacology and Cancer Biology. 2022
• Research
• 

  Selected Grants

  • Genetic dissection of oncogenic RAS-driven tumor initiation in vivo awarded by National Institutes of Health 2022 - 2027
  • Adapting K-MDS to detect KRAS-mutant ctDNA awarded by National Institutes of Health 2022 - 2025
  • PROMINENT - DUKE awarded by National Cancer Institute 2022 - 2023
  • PROMINENT - Discovering the molecular signatures of cancer PROMotion to INform prevENTion awarded by International Agency for Research on Cancer 2022 - 2023
  • Defining RAS isoform- and mutation-specific roles in oncogenesis awarded by University of North Carolina - Chapel Hill 2016 - 2022
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Le Roux, Özgün, Nicole L. K. Pershing, Erin Kaltenbrun, Nicole J. Newman, Jeffrey I. Everitt, Elisa Baldelli, Mariaelena Pierobon, Emanuel F. Petricoin, and Christopher M. Counter. “Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis.” Elife 11 (September 7, 2022). https://doi.org/10.7554/eLife.75715.
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    • Erdogan, Ozgun, Nicole L. K. Pershing, Erin Kaltenbrun, Nicole Newman, Jeffrey Everitt, and Christopher Counter. “RAS mutation patterns arise from tissue-specific responses to distinct oncogenic signaling,” 2021. https://doi.org/10.1101/2021.12.10.472098.
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    • Martinez-Rodriguez, Luis, Ozgün Erdogan, Mariel Jimenez-Rodriguez, Katiria Gonzalez-Rivera, Tishan Williams, Li Li, Violotta Weinreb, et al. “Functional Class I and II amino acid-activating enzymes can be coded by opposite strands of the same gene.” The Journal of Biological Chemistry 291, no. 45 (November 2016): 23830–31. https://doi.org/10.1074/jbc.a115.642876.
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    • Erdoğan, Özgün, Ling Xie, Li Wang, Bing Wu, Qing Kong, Yisong Wan, and Xian Chen. “Proteomic dissection of LPS-inducible, PHF8-dependent secretome reveals novel roles of PHF8 in TLR4-induced acute inflammation and T cell proliferation.” Scientific Reports 6 (April 2016): 24833. https://doi.org/10.1038/srep24833.
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    • Martinez-Rodriguez, Luis, Ozgün Erdogan, Mariel Jimenez-Rodriguez, Katiria Gonzalez-Rivera, Tishan Williams, Li Li, Violetta Weinreb, et al. “Functional Class I and II Amino Acid-activating Enzymes Can Be Coded by Opposite Strands of the Same Gene.” The Journal of Biological Chemistry 290, no. 32 (August 2015): 19710–25. https://doi.org/10.1074/jbc.m115.642876.
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    • Carter, Charles W., Li Li, Violetta Weinreb, Martha Collier, Katiria Gonzalez-Rivera, Mariel Jimenez-Rodriguez, Ozgün Erdogan, et al. “The Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed.” Biology Direct 9 (June 2014): 11. https://doi.org/10.1186/1745-6150-9-11.
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    • Chandrasekaran, Srinivas Niranj, Galip Gürkan Yardimci, Ozgün Erdogan, Jeffrey Roach, and Charles W. Carter. “Statistical evaluation of the Rodin-Ohno hypothesis: sense/antisense coding of ancestral class I and II aminoacyl-tRNA synthetases.” Molecular Biology and Evolution 30, no. 7 (July 2013): 1588–1604. https://doi.org/10.1093/molbev/mst070.
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    • Pham, Yen, Li Li, Aram Kim, Ozgun Erdogan, Violetta Weinreb, Glenn L. Butterfoss, Brian Kuhlman, and Charles W. Carter. “A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases.” Molecular Cell 25, no. 6 (March 2007): 851–62. https://doi.org/10.1016/j.molcel.2007.02.010.
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  • Book Sections

    • Ergüner, Bekir, Özgün Erdoğan, and Uğur Sezerman. “Prediction and Classification for GPCR Sequences Based on Ligand Specific Features.” In Computer and Information Sciences – ISCIS 2006, 174–81. Springer Berlin Heidelberg, 2006. https://doi.org/10.1007/11902140_20.
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• Teaching & Mentoring
• 

  Advising & Mentoring

  • Research Technicians:
    Nikki Newman (2018-2020)
    Wenceslaus Githiiyi (2021-2022)
    
    Rotation Students:
    Min-Yu Ko (2020)
    Michael Caminear (2021)
    Alex George (2022)
    Emma Beane (2022)
• Scholarly, Clinical, & Service Activities
• 

  Presentations & Appearances

  • A Tissue sensitivity atlas to oncogenic RAS mutations . 2022 GEMS Fall Meeting. Genetic and Environmental Mutagenesis Society. 2022  2022
  • A Tissue sensitivity atlas to oncogenic RAS mutations . 2022 PCB Fall Retreat. Duke Pharmacology and Cancer Biology. 2022  2022
  • A tissue sensitivity atlas to oncogenic RAS mutation . AACR 2022 Annual Meeting. AACR. 2022  2022

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