Scott Michael Palmer Jr.

Journal article J Heart Lung Transplant · August 2026 Donor-derived cell-free DNA (dd-cfDNA) is a validated, highly sensitive, plasma molecular biomarker of allograft injury after solid organ transplantation. Robust experiences with dd-cfDNA testing after kidney and heart transplantation have generated intere ... Full text Link to item Cite

Reduced lung fluid club cell secretory protein informs chronic lung allograft dysfunction risk.

Journal article Eur Respir J · April 2026 BACKGROUND: Lung transplant recipients with lower club cell secretory protein (CCSP) levels in bronchoalveolar lavage fluid (BALF) early post-transplantation are at increased risk for chronic lung allograft dysfunction (CLAD). For CLAD risk stratification, ... Full text Link to item Cite

Expression of complement pathway genes is associated with progression of idiopathic pulmonary fibrosis.

Journal article Respir Res · March 25, 2026 BACKGROUND: Studies suggest that the complement pathway may play a role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We evaluated associations between complement pathway gene expression and clinical outcomes in patients with IPF. METHODS: RN ... Full text Link to item Cite

Timing of quality of life and lung function changes during the first year following lung transplantation: A multicenter prospective cohort study.

Journal article J Heart Lung Transplant · March 2026 BACKGROUND: Lung transplantation (LT) has been shown to improve lung function and quality of life (QoL). We sought to clarify if QoL improvements coincide with improvements in spirometry assessments in the first post-transplant year. METHODS: In the multic ... Full text Link to item Cite

The NHLBI lung transplant consortium 2025 steering committee report: Strategies to maximize the use of the consortium for advancing lung transplantation.

Journal article J Heart Lung Transplant · March 2026 The Lung Transplant Consortium (LTC), sponsored by the National Heart, Lung, and Blood Institute (NHLBI) is a 20-center collaboration among lung transplant programs in North America conducting both smaller multicenter projects and one consortium-wide prosp ... Full text Link to item Cite

Clinical features associated with chronic lung allograft dysfunction progression in a multicenter cohort.

Journal article Am J Respir Crit Care Med · March 1, 2026 RATIONALE: Clinical features that impact outcomes in lung recipients with chronic lung allograft dysfunction (CLAD) are uncertain and limited by existing approaches to phenotyping that rely on measures inconsistently performed or not standardized across ce ... Full text Link to item Cite

Considerations for Endpoints in Lung Transplant Clinical Trials: An ISHLT Consensus Statement.

Journal article J Heart Lung Transplant · February 2026 Clinical trials in lung transplantation have been hindered by a lack of clarity on the formulation and significance of endpoints for evaluating therapeutic efficacy. To address this challenge, a multidisciplinary working group from the International Societ ... Full text Link to item Cite

Considerations for Endpoints in Lung Transplant Clinical Trials: Perspective on the ISHLT Consensus Statement.

Journal article J Heart Lung Transplant · February 2026 Full text Link to item Cite

Prolonged Invasive Mechanical Ventilation is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction: A Lung Transplant Outcomes Group Study.

Journal article Clin Transplant · January 2026 INTRODUCTION: Prolonged invasive mechanical ventilation (IMV) after lung transplantation is an appealing early prognostic outcome as it can be reproducibly assessed both prospectively and retrospectively. Whether use of IMV at 72 h after lung transplantati ... Full text Link to item Cite

Development and validation of a bronchoalveolar lavage genomic classifier for acute cellular rejection.

Journal article EBioMedicine · December 2025 BACKGROUND: Acute cellular rejection (ACR) is the main risk factor for chronic lung allograft dysfunction (CLAD), but diagnosis requires invasive transbronchial biopsy (TBB). We previously demonstrated the feasibility of bronchoalveolar lavage cell pellet ... Full text Link to item Cite

Telehealth interventions to improve outcomes in lung transplant recipients: Primary results of the INSPIRE-III randomized clinical trial.

Journal article J Heart Lung Transplant · September 2025 BACKGROUND: There is growing evidence that many patients undergoing lung transplantation report significant distress and low physical activity (PA), which might not improve despite lung transplantation and may be associated with worse clinical outcomes. Fe ... Full text Link to item Cite

An open letter to the ISHLT and its global lung transplantation community.

Journal article J Heart Lung Transplant · September 2025 Full text Link to item Cite

Changes in Lung Function and Mortality Risk in Patients With Idiopathic Pulmonary Fibrosis.

Journal article Chest · August 2025 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease associated with lung function decline and high mortality. RESEARCH QUESTION: What are the associations between thresholds of lung function decline and the ... Full text Link to item Cite

Basiliximab induction immunosuppression and lung transplant outcomes: Propensity analysis in a multicenter cohort.

Journal article J Heart Lung Transplant · June 2025 BACKGROUND: Basiliximab induction immunosuppression is increasingly employed in lung transplant recipients despite limited prospective evidence to support its use in this population. We sought to determine the relationship between basiliximab induction and ... Full text Link to item Cite

Racial disparities in lung function by pulmonary function testing among lung transplant candidates and race-specific reference equations.

Journal article JHLT Open · May 2025 Non-White patients with interstitial lung disease (ILD) experience racial disparities in lung transplant waitlist mortality. Race-specific equations for spirometry may contribute by underestimating restriction severity in non-White candidates. We analyzed ... Full text Link to item Cite

Circulating prostasin is an independent marker of mortality risk in patients with idiopathic pulmonary fibrosis.

Journal article ERJ Open Res · May 2025 BACKGROUND: Prostasin is expressed in the lung epithelium where it regulates fluid and electrolyte balance via sodium channel proteolysis. We investigated whether circulating prostasin levels are associated with the presence and severity of idiopathic pulm ... Full text Link to item Cite

Identification and validation of a threshold for early posttransplant bronchoalveolar fluid hyaluronan that distinguishes lung recipients at risk for chronic lung allograft dysfunction.

Journal article J Heart Lung Transplant · March 2025 BACKGROUND: Few tools exist for the early identification of patients at risk for chronic lung allograft dysfunction (CLAD). We previously showed hyaluronan (HA), a matrix molecule that regulates lung inflammation and fibrosis, accumulates in bronchoalveola ... Full text Link to item Cite

Extent of lung fibrosis is of greater prognostic importance than HRCT pattern in patients with progressive pulmonary fibrosis: data from the ILD-PRO registry.

Journal article Respir Res · February 28, 2025 BACKGROUND: The prognostic value of patterns and quantitative measures of lung fibrosis on high-resolution computed tomography (HRCT) in patients identified as having progressive pulmonary fibrosis (PPF) has not been established. We investigated whether HR ... Full text Link to item Cite

Diagnostic alignment to optimize inter-rater reliability among lung transplant pathologists.

Journal article J Heart Lung Transplant · February 2025 BACKGROUND: Poor agreement among lung transplant (LTx) pathologists has been reported in the assessment of rejection. In addition to acute rejection (AR) and lymphocytic bronchiolitis (LB), acute lung injury (ALI) and organizing pneumonia (OP) were recentl ... Full text Link to item Cite

Prognosis and Risks for Probable Chronic Lung Allograft Dysfunction: A Prospective Multicenter Study.

Journal article Am J Respir Crit Care Med · February 2025 Rationale: Chronic lung allograft dysfunction (CLAD) hinders lung transplant success. A 2019 consensus refined CLAD diagnosis, introducing probable or definite CLAD based on persistence of lung function decline. Outcomes and risks for probable CLAD remain ... Full text Link to item Cite

Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.

Journal article J Am Heart Assoc · January 21, 2025 BACKGROUND: Meta-analyses have suggested that the risk of cardiovascular disease events is significantly higher after a chronic obstructive pulmonary disease (COPD) exacerbation, but the populations at highest risk have not been well characterized to date. ... Full text Link to item Cite

Alterations in circulating measures of Th2 immune responses pre-lung transplant associates with reduced primary graft dysfunction.

Journal article J Heart Lung Transplant · November 2024 Primary graft dysfunction (PGD) is a complication of lung transplantation that continues to cause significant morbidity. The Th2 immune response has been shown to counteract tissue-damaging inflammation. We hypothesized that Th2 cytokines/chemokines in blo ... Full text Link to item Cite

Risk of Atherosclerotic Cardiovascular Disease Hospitalizations after Chronic Obstructive Pulmonary Disease Hospitalization among Older Adults.

Journal article Ann Am Thorac Soc · November 2024 Rationale: Meta-analyses have suggested the risk of cardiovascular disease (CVD) events is significantly higher after a chronic obstructive pulmonary disease (COPD) exacerbation. However, many of these studies have included a broad array of CVD events or h ... Full text Link to item Cite

Design and baseline characteristics of the ILD-PRO registry in patients with progressive pulmonary fibrosis.

Journal article BMC Pulm Med · September 27, 2024 BACKGROUND: To assess the characteristics of patients enrolled in the ILD-PRO Registry. METHODS: The ILD-PRO Registry is a multicentre US registry of patients with progressive pulmonary fibrosis. This registry is enrolling patients with an interstitial lun ... Full text Link to item Cite

Comparison of race-specific and race-neutral spirometry equations on the classification of restrictive lung physiology, interstitial lung disease, and lung transplant referral eligibility.

Journal article JHLT Open · August 2024 BACKGROUND: Race-specific reference equations for spirometry, including forced vital capacity (FVC), are under scrutiny in interstitial lung disease (ILD). Their influence on ILD and transplant decision-making warrants study. METHODS: We performed a retros ... Full text Link to item Cite

Evaluating longitudinal cytomegalovirus-specific humoral immune responses and association with DNAemia risk in seropositive lung transplant recipients.

Journal article JHLT Open · August 2024 BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection among lung transplant recipients and is associated with chronic lung allograft dysfunction. There is a need for better therapeutics as well as biomarkers to enable effective stratificatio ... Full text Link to item Cite

Hyperpolarized 129Xe MRI and spectroscopy of gas-exchange abnormalities in bilateral lung transplant recipients.

Journal article JHLT Open · August 2024 BACKGROUND: There is currently no sensitive, noninvasive method of screening for chronic lung allograft dysfunction (CLAD), the primary barrier to long-term survival after lung transplant. Conventional pulmonary function testing is imprecise absent a susta ... Full text Link to item Cite

Body mass index and mortality following primary graft dysfunction: A Lung Transplant Outcomes Group study.

Journal article JHLT Open · August 2024 Higher body mass index (BMI) increases the risk of developing primary graft dysfunction (PGD) after lung transplantation; whether BMI is associated with decreased survival after PGD is unknown. We utilized the Lung Transplant Outcomes Group cohort of 1,538 ... Full text Link to item Cite

Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates.

Journal article J Heart Lung Transplant · April 2024 BACKGROUND: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Accurate prediction of PGD risk could inform donor approaches and perioperative care planning. We sought to develop a clinically u ... Full text Link to item Cite

Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry.

Journal article Respir Res · January 25, 2024 BACKGROUND: The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis (IPF). We evaluated whether circulating levels of metabolites correlate wi ... Full text Link to item Cite

The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.

Journal article Am J Respir Crit Care Med · January 1, 2024 Rationale: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Prior studies implicated proxy-defined donor smoking as a risk factor for PGD and mortality. Objectives: We aimed to more accuratel ... Full text Link to item Cite

Associations of circulating matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases with clinically relevant outcomes in idiopathic pulmonary fibrosis: Data from the IPF-PRO Registry.

Journal article PLoS One · 2024 INTRODUCTION: We assessed the prognostic utility of circulating levels of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in patients with idiopathic pulmonary fibrosis (IPF) in the IPF-PRO Registry. METHODS: MMP ... Full text Link to item Cite

Accelerating evidence generation: Addressing critical challenges and charting a path forward.

Journal article J Clin Transl Sci · 2024 Efficient evidence generation to assess the clinical and economic impact of medical therapies is critical amid rising healthcare costs and aging populations. However, drug development and clinical trials remain far too expensive and inefficient for all sta ... Full text Link to item Cite

Lung transplantation during acute exacerbations of interstitial lung disease and post-transplant survival.

Journal article JHLT Open · December 2023 BACKGROUND: Acute exacerbations of interstitial lung disease (AE-ILD) cause severe respiratory failure, and mortality is high despite treatment. Lung transplantation is an effective therapy for late-stage interstitial lung disease (ILD), but prior studies ... Full text Link to item Cite

Prevalence and significance of clonal hematopoiesis of indeterminate potential in lung transplant recipients.

Journal article BMC Pulm Med · October 30, 2023 BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition of somatic mutations that leads to an expanded blood cell clone, has been associated with development of a pro-inflammatory state. An enhanced or dysregulated i ... Full text Link to item Cite

BAL Fluid Eosinophilia Associates With Chronic Lung Allograft Dysfunction Risk: A Multicenter Study.

Journal article Chest · September 2023 BACKGROUND: Chronic lung allograft dysfunction (CLAD) is the leading cause of death among lung transplant recipients. Eosinophils, effector cells of type 2 immunity, are implicated in the pathobiology of many lung diseases, and prior studies suggest their ... Full text Link to item Cite

Accuracy and Reproducibility of Automated Measurement of Body Composition: A Lung Transplant Body Composition Cohort Study.

Journal article Ann Am Thorac Soc · September 2023 Full text Link to item Cite

External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources.

Journal article Am J Respir Crit Care Med · September 1, 2023 Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which novel therapies are needed. External controls (ECs) could enhance IPF trial efficiency, but the direct comparability of ECs versus concurrent controls is unknown. Object ... Full text Link to item Cite

Lung function trajectories in patients with idiopathic pulmonary fibrosis.

Journal article Respir Res · August 24, 2023 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease characterised by decline in lung function. We evaluated trajectories of forced vital capacity (FVC) and diffusing capacity (DLco) in a cohort of patients w ... Full text Link to item Cite

Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study.

Journal article J Heart Lung Transplant · June 2023 BACKGROUND: Chronic lung allograft dysfunction (CLAD) increases morbidity and mortality for lung transplant recipients. Club cell secretory protein (CCSP), produced by airway club cells, is reduced in the bronchoalveolar lavage fluid (BALF) of lung recipie ... Full text Link to item Cite

Body Mass Index and Cause-Specific Mortality after Lung Transplantation in the United States.

Journal article Ann Am Thorac Soc · June 2023 Rationale: Low and high body mass index (BMI) are associated with increased mortality after lung transplantation. Why extremes of BMI might increase risk of death is unknown. Objectives: To estimate the association of extremes of BMI with causes of death a ... Full text Link to item Cite

Integrative multi-omics analysis reveals novel idiopathic pulmonary fibrosis endotypes associated with disease progression.

Journal article Respir Res · May 31, 2023 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is characterized by the accumulation of extracellular matrix in the pulmonary interstitium and progressive functional decline. We hypothesized that integration of multi-omics data would identify clinically me ... Full text Link to item Cite

Erratum: Genome-wide Enrichment of TERT Rare Variants in Idiopathic Pulmonary Fibrosis Patients of Latino Ancestry.

Journal article Am J Respir Crit Care Med · May 15, 2023 Full text Link to item Cite

Reflux Surgery in Lung Transplantation: A Multicenter Retrospective Study.

Journal article Ann Thorac Surg · April 2023 BACKGROUND: Aspiration has been associated with graft dysfunction after lung transplantation, leading some to advocate for selective use of fundoplication despite minimal data supporting this practice. METHODS: We performed a multicenter retrospective stud ... Full text Link to item Cite

Effect of Antifibrotic Therapy on Survival in Patients With Idiopathic Pulmonary Fibrosis.

Journal article Clin Ther · April 2023 PURPOSE: Real-world studies have reported reduced mortality in patients with idiopathic pulmonary fibrosis (IPF) treated with antifibrotic therapy; however, the initiation or discontinuation of therapy during these studies may have introduced bias. This st ... Full text Link to item Cite

Evaluation of host cellular responses to Epstein-Barr virus (EBV) in adult lung transplant patients with EBV-associated diseases.

Journal article J Med Virol · April 2023 Epstein-Barr virus (EBV) reactivation is commonly observed in lung transplant recipients (LTRs). However, cellular immune responses to EBV in adult LTRs have not been well described. We aimed to study CD4/CD8 ratio, EBV-specific T cells polyfunctional resp ... Full text Link to item Cite

JAK-STAT activation contributes to cytotoxic T cell-mediated basal cell death in human chronic lung allograft dysfunction.

Journal article JCI Insight · March 22, 2023 Chronic lung allograft dysfunction (CLAD) is the leading cause of death in lung transplant recipients. CLAD is characterized clinically by a persistent decline in pulmonary function and histologically by the development of airway-centered fibrosis known as ... Full text Link to item Cite

Club Cell Secretory Protein in Lung Disease: Emerging Concepts and Potential Therapeutics.

Journal article Annu Rev Med · January 27, 2023 Club cell secretory protein (CCSP), also known as secretoglobin 1A1 (gene name SCGB1A1), is one of the most abundant proteins in the lung, primarily produced by club cells of the distal airway epithelium. At baseline, CCSP is found in large concentrations ... Full text Link to item Cite

Lung Allograft Microbiome Association with Gastroesophageal Reflux, Inflammation, and Allograft Dysfunction.

Journal article Am J Respir Crit Care Med · December 15, 2022 Rationale: It remains unclear how gastroesophageal reflux disease (GERD) affects allograft microbial community composition in lung transplant recipients and its impact on lung allograft inflammation and function. Objectives: Our objective was to compare th ... Full text Link to item Cite

Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.

Journal article Am J Transplant · December 2022 We determined prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP), including timing relative to transplantation, in a multicenter lung recipient cohort. We sought to understand clinical risks that contribute to development of A ... Full text Link to item Cite

Contemporary trends in PGD incidence, outcomes, and therapies.

Journal article J Heart Lung Transplant · December 2022 BACKGROUND: We sought to describe trends in extracorporeal membrane oxygenation (ECMO) use, and define the impact on PGD incidence and early mortality in lung transplantation. METHODS: Patients were enrolled from August 2011 to June 2018 at 10 transplant c ... Full text Link to item Cite

Timing of Treatment Outcomes and Risk Factors for Failure of BPAP in Patients Hospitalized for COPD Exacerbation.

Journal article Respir Care · December 2022 BACKGROUND: Patients hospitalized for COPD exacerbation have an increased risk of mortality, particularly among those who fail bi-level positive airway pressure (BPAP) for hypercapnic respiratory failure subsequently requiring invasive mechanical ventilati ... Full text Link to item Cite

Genome-wide Enrichment of TERT Rare Variants in Idiopathic Pulmonary Fibrosis Patients of Latino Ancestry.

Journal article Am J Respir Crit Care Med · October 1, 2022 Full text Link to item Cite

Plasma CXCL9 and CXCL10 at allograft injury predict chronic lung allograft dysfunction.

Journal article Am J Transplant · September 2022 Histopathologic lung allograft injuries are putative harbingers for chronic lung allograft dysfunction (CLAD). However, the mechanisms responsible are not well understood. CXCL9 and CXCL10 are potent chemoattractants of mononuclear cells and potential prop ... Full text Link to item Cite

Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis.

Journal article Am J Respir Crit Care Med · July 1, 2022 Rationale: Genetic studies of idiopathic pulmonary fibrosis (IPF) have improved our understanding of this disease, but not all causal loci have been identified. Objectives: To identify genes enriched with rare deleterious variants in IPF and familial pulmo ... Full text Link to item Cite

Cost-effectiveness of Pulmonary Rehabilitation Among US Adults With Chronic Obstructive Pulmonary Disease.

Journal article JAMA Netw Open · June 1, 2022 IMPORTANCE: Pulmonary rehabilitation (PR) after exacerbation of chronic obstructive pulmonary disease (COPD) is effective in reducing COPD hospitalizations and mortality while improving health-related quality of life, yet use of PR remains low. Estimates o ... Full text Link to item Cite

LPA1 antagonist BMS-986020 changes collagen dynamics and exerts antifibrotic effects in vitro and in patients with idiopathic pulmonary fibrosis.

Journal article Respir Res · March 18, 2022 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease with limited treatment options. A phase 2 trial (NCT01766817) showed that twice-daily treatment with BMS-986020, a lysophosphatidic acid receptor 1 (LPA1) antagonist, significan ... Full text Link to item Cite

E-cigarette and food flavoring diacetyl alters airway cell morphology, inflammatory and antiviral response, and susceptibility to SARS-CoV-2.

Journal article Cell Death Discov · February 15, 2022 Diacetyl (DA) is an α-diketone that is used to flavor microwave popcorn, coffee, and e-cigarettes. Occupational exposure to high levels of DA causes impaired lung function and obstructive airway disease. Additionally, lower levels of DA exposure dampen hos ... Full text Link to item Cite

Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort.

Journal article Lung · February 2022 Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease with a variable clinical course. Biomarkers that predict patient outcomes are needed. We leveraged data from 300 patients in the multicenter IPF-PRO Registry to determine ass ... Full text Link to item Cite

Correction to: Association of Circulating Proteins with Death or Lung Transplant in Patients with Idiopathic Pulmonary Fibrosis in the IPF-PRO Registry Cohort.

Journal article Lung · February 2022 Full text Link to item Cite

Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1.

Journal article J Clin Invest · January 18, 2022 T cell polyfunctionality is a hallmark of protective immunity against pathogens and cancer, yet the molecular mechanism governing it remains mostly elusive. We found that canonical Wnt agonists inhibited human memory CD8+ T cell differentiation while simul ... Full text Link to item Cite

Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells.

Journal article iScience · December 17, 2021 Currently available SARS-CoV-2 therapeutics are targeted toward moderately to severely ill patients and require intravenous infusions, with limited options for exposed or infected patients with no or mild symptoms. Although vaccines have demonstrated prote ... Full text Link to item Cite

Phase 2 trial design of BMS-986278, a lysophosphatidic acid receptor 1 (LPA1) antagonist, in patients with idiopathic pulmonary fibrosis (IPF) or progressive fibrotic interstitial lung disease (PF-ILD).

Journal article BMJ Open Respir Res · December 2021 INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) and non-IPF, progressive fibrotic interstitial lung diseases (PF-ILD), are associated with a progressive loss of lung function and a poor prognosis. Treatment with antifibrotic agents can slow, but not halt ... Full text Link to item Cite

Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.

Journal article Am J Transplant · October 2021 The histopathologic diagnosis of acute allograft injury is prognostically important in lung transplantation with evidence demonstrating a strong and consistent association between acute rejection (AR), acute lung injury (ALI), and the subsequent developmen ... Full text Link to item Cite

Evidence of Epstein-Barr virus heterogeneous gene expression in adult lung transplant recipients with posttransplant lymphoproliferative disorder.

Journal article J Med Virol · August 2021 Epstein-Barr virus (EBV)-driven posttransplant lymphoproliferative disorder (PTLD) is a serious complication following lung transplant. The extent to which the presence of EBV in PTLD tissue is associated with survival is uncertain. Moreover, whether the h ... Full text Link to item Cite

Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.

Journal article Am J Transplant · June 2021 We undertook a prospective, matched cohort study of patients with Staphylococcus aureus bacteremia (SAB) and gram-negative bacteremia (GNB) to compare the characteristics, outcomes, and chemokine and cytokine response in transplant recipients to immunocomp ... Full text Open Access Link to item Cite

Lung Transplantation: Controversies and Evolving Concepts.

Journal article Semin Respir Crit Care Med · June 2021 Full text Link to item Cite

Intragraft Hyaluronan Increases in Association With Acute Lung Transplant Rejection.

Journal article Transplant Direct · April 2021 BACKGROUND: Acute perivascular rejection (AR) is common in lung recipients and increases the risk for chronic lung allograft dysfunction (CLAD). Hyaluronan (HA), an extracellular matrix constituent, accumulates in experimental AR and can act as an innate i ... Full text Link to item Cite

A three-tier system for evaluation of organ procurement organizations' willingness to pursue and utilize nonideal donor lungs.

Journal article Am J Transplant · March 2021 Lungs from "nonideal," but acceptable donors are underutilized; however, organ procurement organization (OPO) metrics do not reflect the extent to which OPO-specific practices contribute to these trends. We developed a comprehensive system to evaluate noni ... Full text Link to item Cite

Ontology-guided segmentation and object identification for developmental mouse lung immunofluorescent images.

Journal article BMC Bioinformatics · February 23, 2021 BACKGROUND: Immunofluorescent confocal microscopy uses labeled antibodies as probes against specific macromolecules to discriminate between multiple cell types. For images of the developmental mouse lung, these cells are themselves organized into densely p ... Full text Link to item Cite

Primary graft dysfunction and health-related quality of life after transplantation: The good, the bad, and the missing.

Journal article Am J Transplant · February 2021 Full text Link to item Cite

Advances in Human Lung Transplantation.

Journal article Annu Rev Med · January 27, 2021 Lung transplantation improves survival and quality of life in patients with advanced pulmonary disease. Over the past several decades, the volume of lung transplants has grown substantially, with increasing transplantation of older and acutely ill individu ... Full text Link to item Cite

Risk factors for mortality in lung transplant recipients aged ≥65 years: A retrospective cohort study of 5,815 patients in the scientific registry of transplant recipients.

Journal article J Heart Lung Transplant · January 2021 BACKGROUND: Lung transplantation is increasingly performed in recipients aged ≥65 years. However, the risk factors for mortality specific to this population have not been well studied. In lung transplant recipients aged ≥65 years, we sought to determine po ... Full text Link to item Cite

IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages.

Journal article PLoS One · 2021 INTRODUCTION: Anti-inflammatory cytokine IL-10 suppresses pro-inflammatory IL-12b expression after Lipopolysaccharide (LPS) stimulation in colonic macrophages, as part of the innate immunity Toll-Like Receptor (TLR)-NF-κB activation system. This homeostati ... Full text Link to item Cite

Diacetyl exposure disrupts iron homeostasis in animals and cells.

Journal article Inhal Toxicol · 2021 OBJECTIVE: Several mechanisms have been proposed for the biological effect of diacetyl. We tested the postulate that animal and cell exposures to diacetyl are associated with a disruption in iron homeostasis. MATERIALS AND METHODS: Male, Sprague-Dawley rat ... Full text Link to item Cite

A retrospective study of in-hospital mortality in patients with idiopathic pulmonary fibrosis between 2015 and 2018.

Journal article Medicine (Baltimore) · November 20, 2020 Hospitalizations are common in patients with idiopathic pulmonary fibrosis (IPF) and are associated with high mortality. We used data from the Premier Healthcare Database to determine in-hospital mortality rates and the factors associated with in-hospital ... Full text Link to item Cite

Depression, Immunosuppressant Levels, and Clinical Outcomes in Postlung Transplant Recipients.

Journal article Int J Psychiatry Med · November 2020 OBJECTIVE: Posttransplant depression has been linked to increased risk for adverse outcomes in lung transplant patients. Maintaining target serum immunosuppressant levels is also essential for optimal lung transplant clinical outcome and may be a crucial p ... Full text Link to item Cite

Antifibrotic Drug Use in Patients with Idiopathic Pulmonary Fibrosis. Data from the IPF-PRO Registry.

Journal article Ann Am Thorac Soc · November 2020 Rationale: Two antifibrotic medications, nintedanib and pirfenidone, have been approved for the treatment of idiopathic pulmonary fibrosis (IPF) in the United States. Few data have been published on the use of these medications in clinical practice.Objecti ... Full text Link to item Cite

Identifying host microRNAs in bronchoalveolar lavage samples from lung transplant recipients infected with Aspergillus.

Journal article J Heart Lung Transplant · November 2020 BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs of ∼22 nucleotides that play a crucial role in post-transcriptional regulation of gene expression. Dysregulation of miRNA expression has been shown during microbial infections. We sought to identify ... Full text Link to item Cite

Thoracic Visceral Adipose Tissue Area and Pulmonary Hypertension in Lung Transplant Candidates. The Lung Transplant Body Composition Study.

Journal article Ann Am Thorac Soc · November 2020 Rationale: Obesity is associated with an increased risk of pulmonary hypertension (PH); however, regional adipose tissue deposition is heterogeneous with distinct cardiovascular phenotypes.Objectives: To determine the association of body mass index (BMI) a ... Full text Link to item Cite

Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration.

Journal article J Heart Lung Transplant · September 2020 BACKGROUND: Gastroesophageal reflux disease (GERD) is a risk factor for chronic lung allograft dysfunction. Bile acids-putative markers of gastric microaspiration-and inflammatory proteins in the bronchoalveolar lavage (BAL) have been associated with chron ... Full text Link to item Cite

Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.

Journal article Thorax · September 2020 CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transpl ... Full text Link to item Cite

Risk Factors for Acute Rejection in the First Year after Lung Transplant. A Multicenter Study.

Journal article Am J Respir Crit Care Med · August 15, 2020 Rationale: Acute rejection, manifesting as lymphocytic inflammation in a perivascular (acute perivascular rejection [AR]) or peribronchiolar (lymphocytic bronchiolitis [LB]) distribution, is common in lung transplant recipients and increases the risk for c ... Full text Link to item Cite

Hospital-Based Resource Use and Costs Among Patients With Idiopathic Pulmonary Fibrosis Enrolled in the Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry.

Journal article Chest · June 2020 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a rare and serious condition that is associated with high health-care resource use. The goal of this study was to estimate hospital-related resource use and costs by using a national, prospective registry ... Full text Link to item Cite

Associations between Patient-reported Outcomes and Death or Lung Transplant in Idiopathic Pulmonary Fibrosis. Data from the Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry.

Journal article Ann Am Thorac Soc · June 2020 Rationale: Progression of idiopathic pulmonary fibrosis (IPF) is accompanied by worsening of symptoms, exercise capacity, and health-related quality of life. However, the utility of patient-reported outcomes as predictors of mortality remains uncertain.Obj ... Full text Link to item Cite

Highlights from the clinical trials in organ transplantation (CTOT)-20 and CTOT-22 Consortium studies in lung transplant.

Journal article Am J Transplant · June 2020 Long-term survival after lung transplant lags behind that of other commonly transplanted organs, reflecting the current incomplete understanding of the mechanisms involved in the development of posttransplant lung injury, rejection, infection, and chronic ... Full text Link to item Cite

Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry.

Journal article Chest · May 2020 BACKGROUND: Limited data are available on the association between clinically measured disease severity markers and quality of life (QOL) in idiopathic pulmonary fibrosis (IPF). The study examined the associations between objective disease severity metrics ... Full text Link to item Cite

Association of Discharge Immunosuppression Regimen and Post-Transplant Outcomes in Lung Transplantation: An Analysis of OPTN Data

Journal article The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · April 1, 2020 PURPOSE: The optimal immunosuppressive (IS) regimen after lung (LU) transplant is unknown, therefore we sought to examine OPTN data to compare the impact of 4 different IS combinations on outcomes of treated acute rejection (AR), bronchiolitis obliterans s ... Full text Cite

Circulating matrix metalloproteinases and tissue metalloproteinase inhibitors in patients with idiopathic pulmonary fibrosis in the multicenter IPF-PRO Registry cohort.

Journal article BMC Pulm Med · March 14, 2020 BACKGROUND: Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) play important roles in the turnover of extracellular matrix and in the pathogenesis of idiopathic pulmonary fibrosis (IPF). This study aimed to determine the utility of cir ... Full text Link to item Cite

Histone Deacetylase 7 Inhibition in a Murine Model of Gram-Negative Pneumonia-Induced Acute Lung Injury.

Journal article Shock · March 2020 BACKGROUND: Pulmonary infections remain the most common cause of Acute Respiratory Distress Syndrome (ARDS), a pulmonary inflammatory disease with high mortality, for which no targeted therapy currently exists. We have previously demonstrated an ameliorate ... Full text Link to item Cite

Histone Deacetylase 7 in Murine Gram-Negative Acute Lung Injury.

Journal article Shock · March 2020 Full text Link to item Cite

Amphiregulin contributes to airway remodeling in chronic allograft dysfunction after lung transplantation.

Journal article Am J Transplant · March 2020 Chronic lung allograft dysfunction (CLAD), a condition of excess matrix deposition and airways fibrosis, limits survival after lung transplantation. Amphiregulin (Areg) is an epidermal growth factor receptor (EGFR) ligand suggested to regulate airway injur ... Full text Link to item Cite

Overview and Challenges of Bronchiolar Disorders.

Journal article Ann Am Thorac Soc · March 2020 Bronchiolar abnormalities are common and can occur in conditions that affect either the large airways or the more distal parenchyma. In this review, we focus on the diagnosis and management of primary bronchiolar disorders, or conditions in which bronchiol ... Full text Link to item Cite

Remote Therapy to Improve Outcomes in Lung Transplant Recipients: Design of the INSPIRE-III Randomized Clinical Trial.

Journal article Transplant Direct · March 2020 BACKGROUND: Impaired functional capacity and emotional distress are associated with lower quality of life (QoL) and worse clinical outcomes in post lung transplant patients. Strategies to increase physical activity and reduce distress are needed. METHODS: ... Full text Link to item Cite

Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study.

Journal article J Heart Lung Transplant · December 2019 BACKGROUND: Obesity is associated with an increased risk of primary graft dysfunction (PGD) after lung transplantation. The contribution of specific adipose tissue depots is unknown. METHODS: We performed a prospective cohort study of adult lung transplant ... Full text Link to item Cite

In-Hospital Mortality in Patients with Idiopathic Pulmonary Fibrosis: A US Cohort Study.

Journal article Lung · December 2019 PURPOSE: In patients with idiopathic pulmonary fibrosis (IPF), hospitalizations are associated with high mortality. We sought to determine in-hospital mortality rates and factors associated with in-hospital mortality in patients with IPF. METHODS: Patients ... Full text Link to item Cite

A nonlinear relationship between visceral adipose tissue and frailty in adult lung transplant candidates.

Journal article Am J Transplant · November 2019 Frailty is a state of decreased physiologic reserve associated with poor outcomes before and after lung transplantation. Obesity, particularly central obesity characterized by excess proinflammatory visceral adipose tissue (VAT), is associated with inciden ... Full text Link to item Cite

IL-17A Contributes to Lung Fibrosis in a Model of Chronic Pulmonary Graft-versus-host Disease.

Journal article Transplantation · November 2019 BACKGROUND: Chronic pulmonary graft-versus-host disease (cpGVHD) after hematopoietic cell transplant (HCT) manifests as progressive airway and parenchymal lung fibrosis. On the basis of our prior data, mice that undergo allogeneic HCT with Tbet-knockout do ... Full text Link to item Cite

Peripheral blood proteomic profiling of idiopathic pulmonary fibrosis biomarkers in the multicentre IPF-PRO Registry.

Journal article Respir Res · October 22, 2019 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which diagnosis and management remain challenging. Defining the circulating proteome in IPF may identify targets for biomarker development. We sought to quantify the circulat ... Full text Link to item Cite

Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants.

Journal article Chest · September 2019 BACKGROUND: Pulmonary fibrosis (PF) is the most common disease indication for lung transplantation. Our recent work implicated an excess of rare genetic variants in the telomere-related genes TERT, RTEL1, and PARN in PF disease risk. The impact of such var ... Full text Link to item Cite

Usefulness of gene expression profiling of bronchoalveolar lavage cells in acute lung allograft rejection.

Journal article J Heart Lung Transplant · August 2019 BACKGROUND: Chronic lung allograft dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Because effective therapies are lacking, early identification and mitigation of risk factors is a pragmatic approach to improve o ... Full text Link to item Cite

Decreased Antibiotic Utilization After Sinus Surgery in Cystic Fibrosis Patients With Lung Transplantation.

Journal article Am J Rhinol Allergy · July 2019 Full text Link to item Cite

EGFR-Dependent IL8 Production by Airway Epithelial Cells After Exposure to the Food Flavoring Chemical 2,3-Butanedione.

Journal article Toxicol Sci · June 1, 2019 2,3-Butanedione (DA), a component of artificial butter flavoring, is associated with the development of occupational bronchiolitis obliterans (BO), a disease of progressive airway fibrosis resulting in lung function decline. Neutrophilic airway inflammatio ... Full text Link to item Cite

Predictors of death or lung transplant after a diagnosis of idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry.

Journal article Respir Res · May 30, 2019 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a variable clinical course and high mortality. We used data from a large national US registry of patients with IPF to investigate relationships between patient characteristics, i ... Full text Link to item Cite

Chronic lung allograft dysfunction: Definition and update of restrictive allograft syndrome-A consensus report from the Pulmonary Council of the ISHLT.

Journal article J Heart Lung Transplant · May 2019 Full text Link to item Cite

Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction.

Journal article J Heart Lung Transplant · February 2019 BACKGROUND: Chronic lung allograft dysfunction (CLAD), including the phenotypes of bronchiolitis obliterans syndrome (BOS) and restrictive CLAD (R-CLAD), represents the leading cause of late death after lung transplantation. Little is known, however, regar ... Full text Link to item Cite

Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection.

Journal article J Clin Invest · February 1, 2019 Antibody-mediated rejection (AMR) is a principal cause of acute and chronic failure of lung allografts. However, mechanisms mediating this oftentimes fatal complication are poorly understood. Here, we show that Foxp3+ T cells formed aggregates in rejection ... Full text Link to item Cite

Pre-transplant weight loss and clinical outcomes after lung transplantation.

Journal article J Heart Lung Transplant · December 2018 BACKGROUND: Patients with greater adiposity before lung transplantation are at an increased risk for worse post-transplant outcomes. Few studies have addressed whether pre-transplant weight loss mitigates this risk. In this study we examined the associatio ... Full text Link to item Cite

Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis.

Journal article Chest · November 2018 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) causes irreversible loss of lung function. The lysophosphatidic acid receptor 1 (LPA1) pathway is implicated in IPF etiology. Safety and efficacy of BMS-986020, a high-affinity LPA1 antagonist, was assessed v ... Full text Link to item Cite

Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.

Journal article Am J Transplant · July 2018 The presence of preexisting (memory) or de novo donor-specific HLA antibodies (DSAs) is a known barrier to successful long-term organ transplantation. Yet, despite the fact that laboratory tools and our understanding of histocompatibility have advanced sig ... Full text Link to item Cite

Gene Expression Profiling of Bronchoalveolar Lavage Cells During Aspergillus Colonization of the Lung Allograft.

Journal article Transplantation · June 2018 BACKGROUND: Aspergillus colonization after lung transplant is associated with an increased risk of chronic lung allograft dysfunction (CLAD). We hypothesized that gene expression during Aspergillus colonization could provide clues to CLAD pathogenesis. MET ... Full text Link to item Cite

Current challenges and opportunities in the management of antibody-mediated rejection in lung transplantation.

Journal article Curr Opin Organ Transplant · June 2018 PURPOSE OF REVIEW: There is increasing recognition of the importance of antibody-mediated rejection (AMR) after lung transplantation. The development of donor-specific antibodies, a key feature of AMR, occurs in approximately 30% of lung transplant recipie ... Full text Link to item Cite

Depression, social support, and clinical outcomes following lung transplantation: a single-center cohort study.

Journal article Transpl Int · May 2018 Depressive symptoms are common among lung transplant candidates and have been associated with poorer clinical outcomes in some studies. Previous studies have been plagued by methodologic problems, including small sample sizes, few clinical events, and unco ... Full text Link to item Cite

Complement system in lung transplantation.

Journal article Clin Transplant · April 2018 The complement system is a cascade of multiple proteins that have been known to mediate inflammatory response. This tightly regulated system has been recognized to play a role in adaptive immunity via humoral and cell-mediated processes. There is evidence ... Full text Link to item Cite

Neurological Sequelae and Clinical Outcomes After Lung Transplantation.

Journal article Transplant Direct · April 2018 BACKGROUND: Neurological complications are common after lung transplantation. However, no large cohort studies have examined the incidence, predictors, and clinical significance of neurological events sustained by lung transplant recipients. METHODS: We co ... Full text Open Access Link to item Cite

Postoperative cognitive dysfunction and mortality following lung transplantation.

Journal article Am J Transplant · March 2018 Preliminary evidence suggests that postoperative cognitive dysfunction (POCD) is common after lung transplantation. The impact of POCD on clinical outcomes has yet to be studied. The association between POCD and longer-term survival was therefore examined ... Full text Link to item Cite

Correlation between sinus and lung cultures in lung transplant patients with cystic fibrosis.

Journal article Int Forum Allergy Rhinol · March 2018 BACKGROUND: Lung transplantation has revolutionized the treatment of end-stage pulmonary disease due to cystic fibrosis. However, infection of the transplanted lungs can lead to serious complications, including graft failure and death. Although many of the ... Full text Link to item Cite

Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov.

Journal article Clin Trials · February 2018 Background/aims The Food and Drug Administration Amendments Act mandates that applicable clinical trials report basic summary results to the ClinicalTrials.gov database within 1 year of trial completion or termination. We aimed to determine the proportion ... Full text Link to item Cite

Cell-free hemoglobin promotes primary graft dysfunction through oxidative lung endothelial injury.

Journal article JCI Insight · January 25, 2018 Primary graft dysfunction (PGD) is acute lung injury within 72 hours of lung transplantation. We hypothesized that cell-free hemoglobin (CFH) contributes to PGD by increasing lung microvascular permeability and tested this in patients, ex vivo human lungs, ... Full text Link to item Cite

Quantitative Evidence for Revising the Definition of Primary Graft Dysfunction after Lung Transplant.

Journal article Am J Respir Crit Care Med · January 15, 2018 RATIONALE: Primary graft dysfunction (PGD) is a form of acute lung injury that occurs after lung transplantation. The definition of PGD was standardized in 2005. Since that time, clinical practice has evolved, and this definition is increasingly used as a ... Full text Link to item Cite

LungMAP: The Molecular Atlas of Lung Development Program.

Journal article Am J Physiol Lung Cell Mol Physiol · November 1, 2017 The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by i ... Full text Link to item Cite

Clinical Risk Factors and Prognostic Model for Primary Graft Dysfunction after Lung Transplantation in Patients with Pulmonary Hypertension.

Journal article Ann Am Thorac Soc · October 2017 RATIONALE: Pulmonary hypertension from pulmonary arterial hypertension or parenchymal lung disease is associated with an increased risk for primary graft dysfunction after lung transplantation. OBJECTIVE: We evaluated the clinical determinants of severe pr ... Full text Link to item Cite

Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction.

Journal article Ann Am Thorac Soc · September 2017 Lung transplantation is now considered to be a therapeutic option for patients with advanced-stage lung diseases. Unfortunately, due to post-transplant complications, both infectious and noninfectious, it is only a treatment and not a cure. Infections (e.g ... Full text Link to item Cite

Models of toxicity of diacetyl and alternative diones.

Journal article Toxicology · August 1, 2017 Diacetyl (DA; 2,3-butanedione), with the chemical formula (CH3CO)2 is a volatile organic compound with a deep yellow color and a strong buttery flavor and aroma. These properties have made DA a particularly useful and common food flavoring ingredient. Howe ... Full text Link to item Cite

An Exome Sequencing Study to Assess the Role of Rare Genetic Variation in Pulmonary Fibrosis.

Journal article Am J Respir Crit Care Med · July 1, 2017 RATIONALE: Idiopathic pulmonary fibrosis (IPF) is an increasingly recognized, often fatal lung disease of unknown etiology. OBJECTIVES: The aim of this study was to use whole-exome sequencing to improve understanding of the genetic architecture of pulmonar ... Full text Link to item Cite

The utility of 6-minute walk distance in predicting waitlist mortality for lung transplant candidates.

Journal article J Heart Lung Transplant · July 2017 BACKGROUND: The lung allocation score (LAS) has led to improved organ allocation for transplant candidates. At present, the 6-minute walk distance (6MWD) is treated as a binary categorical variable of whether or not a candidate can walk more than 150 feet ... Full text Link to item Cite

Danger signals in regulating the immune response to solid organ transplantation.

Journal article J Clin Invest · June 30, 2017 Endogenous danger signals, or damage-associated molecular patterns (DAMPs), are generated in response to cell stress and activate innate immunity to provide a pivotal mechanism by which an organism can respond to damaged self. Accumulating experimental and ... Full text Link to item Cite

The Diacetyl-Exposed Human Airway Epithelial Secretome: New Insights into Flavoring-Induced Airways Disease.

Journal article Am J Respir Cell Mol Biol · June 2017 Bronchiolitis obliterans (BO) is an increasingly important lung disease characterized by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavoring ingredient diacetyl, commonly used to impart ... Full text Link to item Cite

Clinical predictors and outcome implications of early readmission in lung transplant recipients.

Journal article J Heart Lung Transplant · May 2017 BACKGROUND: The purpose of this study was to identify risk factors and outcome implications for 30-day hospital readmission in lung transplant recipients. METHODS: We conducted a retrospective cohort study of lung transplant cases from a single, high-volum ... Full text Link to item Cite

Antibody depletion strategy for the treatment of suspected antibody-mediated rejection in lung transplant recipients: Does it work?

Journal article Clin Transplant · March 2017 BACKGROUND: Donor-specific antibodies (DSAs) after lung transplantation correlate with poor outcomes. The ideal treatment strategy for antibody-mediated rejection AMR is not defined. Our institution implemented an aggressive multimodality protocol for the ... Full text Link to item Cite

Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl.

Journal article J Proteome Res · February 3, 2017 Occupational exposures to the diketone flavoring agent, diacetyl, have been associated with bronchiolitis obliterans, a rare condition of airway fibrosis. Model studies in rodents have suggested that the airway epithelium is a major site of diacetyl toxici ... Full text Link to item Cite

Survival Benefit of Lung Transplantation in the Modern Era of Lung Allocation.

Journal article Ann Am Thorac Soc · February 2017 RATIONALE: Lung transplantation is an accepted and increasingly employed treatment for advanced lung diseases, but the anticipated survival benefit of lung transplantation is poorly understood. OBJECTIVES: To determine whether and for which patients lung t ... Full text Link to item Cite

Depressive symptoms and early mortality following lung transplantation: A pilot study.

Journal article Clin Transplant · February 2017 BACKGROUND: Impaired psychological function is common among lung transplant candidates and may affect clinical outcomes following transplantation. Although numerous studies have examined the relationship between pretransplant depression, quality of life (Q ... Full text Link to item Cite

Chest Fat Quantification via CT Based on Standardized Anatomy Space in Adult Lung Transplant Candidates.

Journal article PLoS One · 2017 PURPOSE: Overweight and underweight conditions are considered relative contraindications to lung transplantation due to their association with excess mortality. Yet, recent work suggests that body mass index (BMI) does not accurately reflect adipose tissue ... Full text Link to item Cite

Gene Expression Profiling of Bronchoalveolar Lavage Cells Preceding a Clinical Diagnosis of Chronic Lung Allograft Dysfunction.

Journal article PLoS One · 2017 BACKGROUND: Chronic Lung Allograft Dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Although CLAD is usually not responsive to treatment, earlier identification may improve treatment prospects. METHODS: In a neste ... Full text Link to item Cite

Staging of Bilateral Lung Transplantation for High-Risk Patients With Interstitial Lung Disease: One Lung at a Time.

Journal article Am J Transplant · November 2016 The choice of a single or bilateral lung transplant for interstitial lung disease (ILD) is controversial, as surgical risk, long-term survival and organ allocation are competing factors. In an effort to balance risk and benefit, our center adopted a staged ... Full text Link to item Cite

High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study.

Journal article Eur Respir J · November 2016 Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography (CT) detects lun ... Full text Link to item Cite

Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity.

Journal article Am J Pathol · November 2016 Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl into ac ... Full text Link to item Cite

Validation and Refinement of Chronic Lung Allograft Dysfunction Phenotypes in Bilateral and Single Lung Recipients.

Journal article Ann Am Thorac Soc · May 2016 RATIONALE: The clinical course of chronic lung allograft dysfunction (CLAD) is heterogeneous. Forced vital capacity (FVC) loss at onset, which may suggest a restrictive phenotype, was associated with worse survival for bilateral lung transplant recipients ... Full text Link to item Cite

The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia.

Journal article J Heart Lung Transplant · April 2016 BACKGROUND: Donor smoking history and higher fraction of inspired oxygen (FIO2) at reperfusion are associated with primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidative injury biomarkers would be elevated in PGD, with h ... Full text Link to item Cite

Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk.

Journal article Am J Transplant · March 2016 The authors previously identified plasma plasminogen activator inhibitor-1 (PAI-1) level as a quantitative lung injury biomarker in primary graft dysfunction (PGD). They hypothesized that plasma levels of PAI-1 used as a quantitative trait could facilitate ... Full text Link to item Cite

The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome.

Journal article Am J Transplant · February 2016 Primary graft dysfunction (PGD) is a possible risk factor for bronchiolitis obliterans syndrome (BOS) following lung transplantation; however, the mechanism for any such association is poorly understood. Based on the association of TGF-β with acute and chr ... Full text Link to item Cite

Reduced Cerebral Perfusion Pressure during Lung Transplant Surgery Is Associated with Risk, Duration, and Severity of Postoperative Delirium.

Journal article Ann Am Thorac Soc · February 2016 RATIONALE: Delirium is common following lung transplant and is associated with poorer clinical outcomes. The extent to which intraoperative hemodynamic alterations may contribute to postoperative delirium among lung transplant recipients has not been exami ... Full text Link to item Cite

Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation.

Journal article Am J Respir Crit Care Med · January 1, 2016 RATIONALE: Cytomegalovirus (CMV), which is one of the most common infections after lung transplantation, is associated with chronic lung allograft dysfunction and worse post-transplantation survival. Current approaches for at-risk patients include a fixed ... Full text Link to item Cite

Chronic obstructive pulmonary disease in patients with atrial fibrillation: Insights from the ARISTOTLE trial.

Journal article Int J Cardiol · January 1, 2016 BACKGROUND: Comorbid chronic obstructive pulmonary disease (COPD) is associated with poor outcomes among patients with cardiovascular disease. The risks of stroke and mortality associated with COPD among patients with atrial fibrillation are not well under ... Full text Link to item Cite

Biobehavioral Prognostic Factors in Chronic Obstructive Pulmonary Disease: Results From the INSPIRE-II Trial.

Journal article Psychosom Med · 2016 OBJECTIVE: To examine the prognostic value of select biobehavioral factors in patients with chronic obstructive pulmonary disease (COPD) in a secondary analysis of participants from the INSPIRE-II trial. METHODS: Three hundred twenty-six outpatients with C ... Full text Link to item Cite

Rationale for and design of the Idiopathic Pulmonary Fibrosis-PRospective Outcomes (IPF-PRO) registry.

Journal article BMJ Open Respir Res · 2016 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterised by progressive loss of lung function. Its clinical course is variable but ultimately fatal. There is a need for a multicentre patient registry incorporatin ... Full text Link to item Cite

Psychosocial Predictors of Mortality Following Lung Transplantation.

Journal article Am J Transplant · January 2016 Lung transplantation has become an increasingly common treatment for patients with end-stage lung disease. Few studies have examined psychosocial risk factors for mortality in transplant recipients, despite evidence suggesting that elevated levels of negat ... Full text Link to item Cite

Design and Implementation of the International Genetics and Translational Research in Transplantation Network.

Journal article Transplantation · November 2015 BACKGROUND: Genetic association studies of transplantation outcomes have been hampered by small samples and highly complex multifactorial phenotypes, hindering investigations of the genetic architecture of a range of comorbidities which significantly impac ... Full text Link to item Cite

The utility of preoperative six-minute-walk distance in lung transplantation.

Journal article Am J Respir Crit Care Med · October 1, 2015 RATIONALE: The use of 6-minute-walk distance (6MWD) as an indicator of exercise capacity to predict postoperative survival in lung transplantation has not previously been well studied. OBJECTIVES: To evaluate the association between 6MWD and postoperative ... Full text Link to item Cite

Development and psychometric properties of the Pulmonary-specific Quality-of-Life Scale in lung transplant patients.

Journal article J Heart Lung Transplant · August 2015 BACKGROUND: The Pulmonary-specific Quality-of-Life Scale (PQLS) was developed to measure quality of life (QoL) among patients awaiting lung transplant. The objective of this study was to determine the psychometric properties of the PQLS, identify empirical ... Full text Link to item Cite

Impact of CLAD Phenotype on Survival After Lung Retransplantation: A Multicenter Study.

Journal article Am J Transplant · August 2015 Chronic lung allograft dysfunction (CLAD) remains a major problem after lung transplantation with no definitive treatment except redo lung transplantation (re-LTx) in selected candidates. However, CLAD is not a homogeneous entity and different phenotypes e ... Full text Link to item Cite

Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation.

Journal article Am J Transplant · August 2015 Primary graft dysfunction (PGD) is a major cause of early mortality after lung transplant. We aimed to define objective estimates of PGD risk based on readily available clinical variables, using a prospective study of 11 centers in the Lung Transplant Outc ... Full text Link to item Cite

Association of hospital admission and forced vital capacity endpoints with survival in patients with idiopathic pulmonary fibrosis: analysis of a pooled cohort from three clinical trials.

Journal article Lancet Respir Med · May 2015 BACKGROUND: Mortality is an impractical primary endpoint for clinical trials in patients with idiopathic pulmonary fibrosis who have mild-to-moderate physiological impairment because event rates are low. Change in forced vital capacity (FVC) is widely acce ... Full text Link to item Cite

Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group.

Journal article Ann Am Thorac Soc · March 2015 RATIONALE: The 2011 combined Global Initiative for Chronic Obstructive Lung Disease (GOLD) assessment incorporates symptoms, exacerbation history, and spirometry in discriminating risk of exacerbations in patients with chronic obstructive pulmonary disease ... Full text Link to item Cite

Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation.

Journal article Am J Respir Crit Care Med · February 15, 2015 RATIONALE: Primary graft dysfunction (PGD) causes early mortality after lung transplantation and may contribute to late graft failure. No effective treatments exist. The pathogenesis of PGD is unclear, although both neutrophils and activated platelets have ... Full text Link to item Cite

Delirium affects length of hospital stay after lung transplantation.

Journal article J Crit Care · February 2015 BACKGROUND: Delirium is relatively common after lung transplantation, although its prevalence and prognostic significance have not been systematically studied. The purpose of the present study was to examine pretransplant predictors of delirium and the sho ... Full text Link to item Cite

Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection.

Journal article Transpl Immunol · January 2015 RATIONALE: Bone marrow transplant (BMT) recipients experience frequent and severe respiratory viral infections (RVIs). However, the immunological mechanisms predisposing to RVIs are uncertain. Therefore, we hypothesized that antiviral T cell immunity is im ... Full text Link to item Cite

An assessment of human gastric fluid composition as a function of PPI usage.

Journal article Physiol Rep · January 1, 2015 The standard of care for chronic gastro-esophageal reflux disease (GERD), which affects up to 40% of the population, is the use of drugs such as proton pump inhibitors (PPIs) that block the production of stomach acid. Despite widespread use, the effects of ... Full text Link to item Cite

Gene expression in obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats.

Journal article PLoS One · 2015 Obliterative bronchiolitis (OB) is an irreversible lung disease characterized by progressive fibrosis in the small airways with eventual occlusion of the airway lumens. OB is most commonly associated with lung transplant rejection; however, OB has also bee ... Full text Link to item Cite

Role of C-C motif ligand 2 and C-C motif receptor 2 in murine pulmonary graft-versus-host disease after lipopolysaccharide inhalations.

Journal article Am J Respir Cell Mol Biol · December 2014 Environmental exposures are a potential trigger of chronic pulmonary graft-versus-host disease (pGVHD) after successful recovery from hematopoietic cell transplant (HCT). We hypothesized that inhalations of LPS, a prototypic environmental stimulus, trigger ... Full text Link to item Cite

The Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation best characterizes kidney function in patients being considered for lung transplantation.

Journal article J Heart Lung Transplant · December 2014 BACKGROUND: Methods for direct measurement of glomerular filtration rate (GFR) are expensive and inconsistently applied across transplant centers. The Modified Diet in Renal Disease (MDRD) equation is commonly used for GFR estimation, but is inaccurate for ... Full text Link to item Cite

Neurocognitive changes after lung transplantation.

Journal article Ann Am Thorac Soc · December 2014 RATIONALE: Neurocognitive impairments are associated with reduced quality of life and may adversely affect medical compliance, but their prevalence after lung transplantation has not been extensively studied. OBJECTIVES: To examine the frequency of neuroco ... Full text Link to item Cite

Differential outcomes with early and late repeat transplantation in the era of the lung allocation score.

Journal article Ann Thorac Surg · December 2014 BACKGROUND: Rates of repeat lung transplantation have increased since implementation of the lung allocation score (LAS). The purpose of this study is to compare survival between repeat (ReTx) and primary (LTx) lung transplant recipients in the LAS era. MET ... Full text Link to item Cite

An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome.

Journal article Eur Respir J · December 2014 Bronchiolitis obliterans syndrome (BOS) is a major complication of lung transplantation that is associated with poor survival. The International Society for Heart and Lung Transplantation, American Thoracic Society, and European Respiratory Society convene ... Full text Link to item Cite

Body composition and mortality after adult lung transplantation in the United States.

Journal article Am J Respir Crit Care Med · November 1, 2014 RATIONALE: Obesity and underweight are contraindications to lung transplantation based on their associations with mortality in studies performed before implementation of the lung allocation score (LAS)-based organ allocation system in the United States Obj ... Full text Link to item Cite

Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans.

Journal article Am J Respir Cell Mol Biol · October 2014 Diacetyl (DA), a component of artificial butter flavoring, has been linked to the development of bronchiolitis obliterans (BO), a disease of airway epithelial injury and airway fibrosis. The epidermal growth factor receptor ligand, amphiregulin (AREG), has ... Full text Link to item Cite

The effects of a telehealth coping skills intervention on outcomes in chronic obstructive pulmonary disease: primary results from the INSPIRE-II study.

Journal article Psychosom Med · October 2014 OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is associated with increased morbidity and mortality and reduced quality of life (QoL). Novel interventions are needed to improve outcomes in COPD patients. The present study assessed the effects of a ... Full text Link to item Cite

Alemtuzumab induction in lung transplantation: time to move on?

Journal article Am J Transplant · August 2014 This editorial puts into perspective the findings of the first randomized, controlled trial examining alemtuzumab induction for lung transplantation, and highlights the challenges encountered with alemtuzumab induction in other solid organs. See article by ... Full text Link to item Cite

Update in lung transplantation 2013.

Journal article Am J Respir Crit Care Med · July 1, 2014 Research in pulmonary transplantation is actively evolving in quality and scope to meet the challenges of a growing population of lung allograft recipients. In 2013, research groups leveraged large publicly available datasets in addition to multicenter res ... Full text Link to item Cite

Plasma complement levels are associated with primary graft dysfunction and mortality after lung transplantation.

Journal article Am J Respir Crit Care Med · June 15, 2014 Full text Link to item Cite

Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression.

Journal article Am J Physiol Lung Cell Mol Physiol · June 1, 2014 Epithelial injury is often detected in lung allografts, however, its relation to rejection pathogenesis is unknown. We hypothesized that sterile epithelial injury can lead to alloimmune activation in the lung. We performed adoptive transfer of mismatched s ... Full text Link to item Cite

Antibody desensitization therapy in highly sensitized lung transplant candidates.

Journal article Am J Transplant · April 2014 As HLAs antibody detection technology has evolved, there is now detailed HLA antibody information available on prospective transplant recipients. Determining single antigen antibody specificity allows for a calculated panel reactive antibodies (cPRA) value ... Full text Link to item Cite

Neurobehavioral functioning and survival following lung transplantation.

Journal article Chest · March 1, 2014 BACKGROUND: Neurobehavioral functioning is widely recognized as being an important consideration in lung transplant candidates, but little is known about whether these factors are related to clinical outcomes. The present study examined the relationship of ... Full text Link to item Cite

Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity.

Journal article Am J Respir Crit Care Med · March 1, 2014 RATIONALE: Although innate immunity is increasingly recognized to contribute to lung allograft rejection, the significance of endogenous innate ligands, such as hyaluronan (HA) fragments, in clinical or experimental lung transplantation is uncertain. OBJEC ... Full text Link to item Cite

Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.

Journal article Am J Respir Crit Care Med · March 1, 2014 RATIONALE: Biologic pathways with significant genetic conservation across human populations have been implicated in the pathogenesis of primary graft dysfunction (PGD). The evaluation of the role of recipient genetic variation in PGD has thus far been limi ... Full text Link to item Cite

Preoperative plasma club (clara) cell secretory protein levels are associated with primary graft dysfunction after lung transplantation.

Journal article Am J Transplant · February 2014 Inherent recipient factors, including pretransplant diagnosis, obesity and elevated pulmonary pressures, are established primary graft dysfunction (PGD) risks. We evaluated the relationship between preoperative lung injury biomarkers and PGD to gain furthe ... Full text Link to item Cite

Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction.

Journal article Am J Respir Crit Care Med · January 15, 2014 RATIONALE: Emerging evidence suggests a restrictive phenotype of chronic lung allograft dysfunction (CLAD) exists; however, the optimal approach to its diagnosis and clinical significance is uncertain. OBJECTIVES: To evaluate the hypothesis that spirometri ... Full text Link to item Cite

Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease.

Journal article PLoS One · 2014 BACKGROUND: Pulmonary GVHD (pGVHD) is an important complication of hematopoietic cell transplant (HCT) and is thought to be a consequence of the HCT conditioning regimen, allogeneic donor cells, and posttransplant lung exposures. We have previously demonst ... Full text Link to item Cite

Assessing the causal effect of organ transplantation on the distribution of residual lifetime.

Journal article Biometrics · December 2013 Because the number of patients waiting for organ transplants exceeds the number of organs available, a better understanding of how transplantation affects the distribution of residual lifetime is needed to improve organ allocation. However, there has been ... Full text Link to item Cite

Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease.

Journal article Blood · November 7, 2013 Acute graft-versus-host disease (aGVHD) is the leading cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Approximately 35% to 50% of HCT recipients develop aGVHD; however, there are no validated diagnostic and pred ... Full text Link to item Cite

Using ClinicalTrials.gov to understand the state of clinical research in pulmonary, critical care, and sleep medicine.

Journal article Ann Am Thorac Soc · October 2013 RATIONALE: ClinicalTrials.gov is the largest trial registry in the world. Strengthened registration requirements, including federal mandates in 2007, have increased study representation. A systematic evaluation of all registered studies has been limited by ... Full text Link to item Cite

A comparative analysis of bronchial stricture after lung transplantation in recipients with and without early acute rejection.

Journal article Ann Thorac Surg · September 2013 BACKGROUND: Risk factors and outcomes of bronchial stricture after lung transplantation are not well defined. An association between acute rejection and development of stricture has been suggested in small case series. We evaluated this relationship using ... Full text Link to item Cite

Use of lung allografts from brain-dead donors after cardiopulmonary arrest and resuscitation.

Journal article Am J Respir Crit Care Med · August 15, 2013 RATIONALE: Patients who progress to brain death after resuscitation from cardiac arrest have been hypothesized to represent an underused source of potential organ donors; however, there is a paucity of data regarding the viability of lung allografts after ... Full text Link to item Cite

Latent class analysis identifies distinct phenotypes of primary graft dysfunction after lung transplantation.

Journal article Chest · August 2013 BACKGROUND: There is significant heterogeneity within the primary graft dysfunction (PGD) syndrome. We aimed to identify distinct grade 3 PGD phenotypes based on severity of lung dysfunction and patterns of resolution. METHODS: Subjects from the Lung Trans ... Full text Link to item Cite

Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients.

Journal article Chest · July 2013 BACKGROUND: Long-term survival after lung transplant is limited by the development of chronic and progressive airflow obstruction, a condition known as bronchiolitis obliterans syndrome (BOS). While prior studies strongly implicate cellular rejection as a ... Full text Link to item Cite

An acute change in lung allocation score and survival after lung transplantation: a cohort study.

Journal article Ann Intern Med · May 7, 2013 BACKGROUND: Lung transplantation is an effective treatment for patients with advanced lung disease. In the United States, lungs are allocated on the basis of the lung allocation score (LAS), a composite measure of transplantation urgency and utility. Clini ... Full text Link to item Cite

Colonization with small conidia Aspergillus species is associated with bronchiolitis obliterans syndrome: a two-center validation study.

Journal article Am J Transplant · April 2013 Aspergillus colonization after lung transplantation may increase the risk for bronchiolitis obliterans syndrome (BOS), a disease of small airways. We hypothesized that colonization with small conidia Aspergillus species would be associated with a greater r ... Full text Link to item Cite

Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome.

Journal article Am J Transplant · March 2013 Bronchiolitis obliterans syndrome (BOS), a condition of irreversible small airway fibrosis, is the principal factor limiting long-term survival after lung transplantation. Bronchoscopy and bronchoalveolar lavage (BAL), techniques central to lung transplant ... Full text Link to item Cite

Impact of lung transplantation on recipient quality of life: a serial, prospective, multicenter analysis through the first posttransplant year.

Journal article Chest · March 2013 BACKGROUND: Quality of life (QOL) is an important but understudied outcome after lung transplantation. Previous cross-sectional, single-center studies suggest improved QOL, but few prior longitudinal multicenter data exist regarding the effect of transplan ... Full text Link to item Cite

Clinical risk factors for primary graft dysfunction after lung transplantation.

Journal article Am J Respir Crit Care Med · March 1, 2013 RATIONALE: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. OBJECTIVES: We sought to identify donor, recipient, and periop ... Full text Link to item Cite

Significance of and risk factors for the development of central airway stenosis after lung transplantation.

Journal article Am J Transplant · February 2013 Central airways stenosis (CAS) after lung transplant is a poorly understood complication. Objectives of this study were to determine if CAS was associated with chronic rejection or worse survival after transplant as well as to identify factors associated w ... Full text Link to item Cite

Erratum: Novel role for surfactant protein A in gastrointestinal graft-versus-host disease (The Journal of Immunology (2012) 188 (4897-4905))

Journal article Journal of Immunology · February 1, 2013 Full text Cite

Lung Transplantation For Pulmonary Complications After Bone Marrow Transplantation

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Initial Desensitization Therapy Experience In Lung Transplant Candidates With Elevated Human Leukocyte Antigen Antibodies

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Racial differences in the association of CD14 polymorphisms with serum total IgE levels and allergen skin test reactivity.

Journal article J Asthma Allergy · 2013 BACKGROUND: The CD14 C-159T single nucleotide polymorphism (SNP) has been investigated widely as a candidate genetic locus in patients with allergic disease. There are conflicting results for the association of the CD14 C-159T SNP with total serum immunogl ... Full text Open Access Link to item Cite

Association of anxiety and depression with pulmonary-specific symptoms in chronic obstructive pulmonary disease.

Journal article Int J Psychiatry Med · 2013 OBJECTIVES: To examine the association of anxiety and depression with pulmonary-specific symptoms of Chronic Obstructive Pulmonary Disease (COPD), and to determine the extent to which disease severity and functional capacity modify this association. METHOD ... Full text Link to item Cite

Epithelial clara cell injury occurs in bronchiolitis obliterans syndrome after human lung transplantation.

Journal article Am J Transplant · November 2012 Bronchiolitis obliterans syndrome (BOS) is a condition of progressive airflow obstruction that affects a majority of lung transplant recipients and limits long-term posttransplant survival. Although epithelial injury appears central to the development of B ... Full text Link to item Cite

Clinical year in review I: quality improvement for pulmonary and critical care medicine, lung transplantation, rehabilitation for pulmonary and critically ill patients, and sleep medicine.

Journal article Proc Am Thorac Soc · October 2012 Full text Link to item Cite

Variation in PTX3 is associated with primary graft dysfunction after lung transplantation.

Journal article Am J Respir Crit Care Med · September 15, 2012 RATIONALE: Elevated long pentraxin-3 (PTX3) levels are associated with the development of primary graft dysfunction (PGD) after lung transplantation. Abnormalities in innate immunity, mediated by PTX3 release, may play a role in PGD pathogenesis. OBJECTIVE ... Full text Link to item Cite

Changes in neurocognitive functioning following lung transplantation.

Journal article Am J Transplant · September 2012 Although neurocognitive impairment is relatively common among patients with advanced lung disease, little is known regarding changes in neurocognition following lung transplantation. We therefore administered 10 tests of neurocognitive functioning before a ... Full text Link to item Cite

A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation.

Journal article J Heart Lung Transplant · September 2012 BACKGROUND: We aimed to identify combinations of biomarkers to enhance the definition of primary graft dysfunction (PGD) for translational research. METHODS: Biomarkers reflecting lung epithelial injury (soluble receptor for advance glycation end products ... Full text Link to item Cite

Novel role for surfactant protein A in gastrointestinal graft-versus-host disease.

Journal article J Immunol · May 15, 2012 Graft-versus-host disease (GVHD) is a severe and frequent complication of allogeneic bone marrow transplantation (BMT) that involves the gastrointestinal (GI) tract and lungs. The pathobiology of GVHD is complex and involves immune cell recognition of host ... Full text Link to item Cite

Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation.

Journal article Am J Respir Cell Mol Biol · May 2012 Featured Publication Chemokines and chemokine receptors have been implicated in the pathogenesis of bronchiolitis. CXCR3 ligands (CXCL10, CXCL9, and CXCL11) were elevated in patients with bronchiolitis obliterans syndrome (BOS) and chronic allorejection. Studies also suggested ... Full text Link to item Cite

Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans.

Journal article Toxicol Pathol · April 2012 Featured Publication 2,3-Pentanedione (PD) is a component of artificial butter flavorings. The use of PD is increasing since diacetyl, a major butter flavorant, was associated with bronchiolitis obliterans (BO) in workers and has been removed from many products. Because the to ... Full text Link to item Cite

Is prevention the best treatment? CMV after lung transplantation.

Journal article Am J Transplant · March 2012 Featured Publication Cytomegalovirus (CMV) is the most prevalent opportunistic infection that occurs in lung-transplant recipients. In addition to its direct morbidity, multiple studies have demonstrated that CMV, in particular CMV pneumonia, is associated with an increased ri ... Full text Link to item Cite

Spirometrically significant acute rejection increases the risk for BOS and death after lung transplantation.

Journal article Am J Transplant · March 2012 Featured Publication Acute rejection (AR) is a common complication following lung transplantation and is an established risk factor for bronchiolitis obliterans syndrome (BOS). AR clinical presentation varies considerably and is sometimes associated with an acute decrease in f ... Full text Link to item Cite

Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis.

Journal article Am J Respir Cell Mol Biol · February 2012 Featured Publication T-box expressed in T cells (T-bet) is a critical transcription factor for T helper (Th) 1 responses. Although Th1 cells are thought to contribute to certain alloimmune responses, their role in pulmonary graft-versus-host disease (GVHD) is uncertain. We hav ... Full text Link to item Cite

Stress and coping in caregivers of patients awaiting solid organ transplantation.

Journal article Clin Transplant · 2012 Featured Publication Caregivers for patients undergoing solid organ transplantation play an essential role in the process of transplantation. However, little is known about stress and coping among these caregivers. Six hundred and twenty-one primary caregivers of potential can ... Full text Link to item Cite

Elevated plasma angiopoietin-2 levels and primary graft dysfunction after lung transplantation.

Journal article PLoS One · 2012 INTRODUCTION: Primary graft dysfunction (PGD) is a significant contributor to early morbidity and mortality after lung transplantation. Increased vascular permeability in the allograft has been identified as a possible mechanism leading to PGD. Angiopoieti ... Full text Link to item Cite

Montelukast for Bronchiolitis Obliterans Syndrome After Lung Transplantation: Response.

Journal article Chest · January 2012 Full text Link to item Cite

Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study.

Journal article Am J Respir Crit Care Med · November 1, 2011 Featured Publication RATIONALE: Obesity has been linked to acute lung injury and is a risk factor for early mortality after lung transplantation. OBJECTIVES: To examine the associations of obesity and plasma adipokines with the risk of primary graft dysfunction after lung tran ... Full text Link to item Cite

Elevated plasma long pentraxin-3 levels and primary graft dysfunction after lung transplantation for idiopathic pulmonary fibrosis.

Journal article Am J Transplant · November 2011 Featured Publication Primary graft dysfunction (PGD) after lung transplantation may result from ischemia reperfusion injury (IRI). The innate immune response to IRI may be mediated by Toll-like receptor and IL-1-induced long pentraxin-3 (PTX3) release. We hypothesized that ele ... Full text Link to item Cite

The state of genome-wide association studies in pulmonary disease: a new perspective.

Journal article Am J Respir Crit Care Med · October 15, 2011 Featured Publication With rapid advances in our knowledge of the human genome and increasing availability of high-throughput investigative technology, genome-wide association (GWA) studies have recently gained marked popularity. As an unbiased approach to identifying genomic r ... Full text Link to item Cite

Long-term efficacy and safety of 12 months of valganciclovir prophylaxis compared with 3 months after lung transplantation: a single-center, long-term follow-up analysis from a randomized, controlled cytomegalovirus prevention trial.

Journal article J Heart Lung Transplant · September 2011 Featured Publication BACKGROUND: The optimal approach to cytomegalovirus (CMV) prevention after lung transplantation is controversial. We recently completed a prospective, randomized, placebo-controlled study of CMV prevention in lung transplantation that demonstrated the shor ... Full text Link to item Cite

Effect of single vs bilateral lung transplantation on plasma surfactant protein D levels in idiopathic pulmonary fibrosis.

Journal article Chest · August 2011 Featured Publication BACKGROUND: Serum levels of surfactant protein D (SP-D) have been suggested as reflecting epithelial damage in acute lung injury, COPD, and idiopathic pulmonary fibrosis (IPF). However, little is known about SP-D levels in the setting of lung transplantati ... Full text Link to item Cite

Bronchiolitis obliterans syndrome: the final frontier for lung transplantation.

Journal article Chest · August 2011 Featured Publication Bronchiolitis obliterans syndrome (BOS) is a form of chronic lung allograft dysfunction that affects a majority of lung transplant recipients and is the principal factor limiting long-term transplant survival. BOS is characterized by progressive airflow ob ... Full text Link to item Cite

Acute allograft rejection: cellular and humoral processes.

Journal article Clin Chest Med · June 2011 Featured Publication Acute cellular rejection affects greater than one-third of lung transplant recipients. Alloreactive T-lymphocytes constitute the basis of lung allograft rejection. Recent evidence supports a more complex immune response to the allograft. Interaction betwee ... Full text Link to item Cite

Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3.

Journal article J Heart Lung Transplant · June 2011 Featured Publication BACKGROUND: Pulmonary graft-versus-host disease (GVHD) after hematopoietic cell transplant (HCT) and allograft rejection after lung transplant are parallel immunologic processes that lead to significant morbidity and mortality. Our murine model of pulmonar ... Full text Link to item Cite

In pursuit of new experimental models of obliterative bronchiolitis.

Journal article Am J Transplant · May 2011 Featured Publication Full text Link to item Cite

Lung-resident mesenchymal stromal cells. A new player in post-transplant bronchiolitis obliterans syndrome?

Journal article Am J Respir Crit Care Med · April 15, 2011 Featured Publication Full text Link to item Cite

Elevated pulmonary artery pressure is a risk factor for primary graft dysfunction following lung transplantation for idiopathic pulmonary fibrosis.

Journal article Chest · April 2011 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is often associated with elevations in pulmonary artery pressures. Although primary pulmonary arterial hypertension (PAH) has been associated with primary graft dysfunction (PGD), the role of secondary PAH in ... Full text Link to item Cite

Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats.

Journal article PLoS One · March 25, 2011 Featured Publication BACKGROUND: Bronchiolitis obliterans (BO) is a fibrotic lung disease that occurs in a variety of clinical settings, including toxin exposures, autoimmunity and lung or bone marrow transplant. Despite its increasing clinical importance, little is known rega ... Full text Link to item Cite

Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis.

Journal article Am J Transplant · March 2011 Featured Publication Cytomegalovirus (CMV) is a common opportunistic infection after lung transplant. Despite effective antiviral medications to treat CMV, invasive CMV disease contributes to lung allograft dysfunction and worse survival. Efforts to prevent CMV have led to the ... Full text Link to item Cite

Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction.

Journal article Am J Transplant · March 2011 Featured Publication Primary graft dysfunction (PGD) is the leading cause of early posttransplant morbidity and mortality after lung transplantation. Clara cell secretory protein (CC16) is produced by the nonciliated lung epithelium and may serve as a plasma marker of epitheli ... Full text Link to item Cite

Survival after bronchiolitis obliterans syndrome.

Journal article Am J Respir Crit Care Med · February 15, 2011 Full text Link to item Cite

Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant.

Journal article Transpl Immunol · January 15, 2011 Respiratory viral infections cause significant morbidity and increase the risk for chronic pulmonary graft-versus-host disease (GVHD) after hematopoietic cell transplantation (HCT). Our overall hypothesis is that local innate immune activation potentiates ... Full text Link to item Cite

Osteoporosis in lung transplant candidates compared to matched healthy controls.

Journal article Clin Transplant · 2011 PURPOSE: Advanced lung disease increases the risk for diminished bone mineral density (BMD). The prevalence and severity of osteoporosis in lung transplant candidates is unclear. METHODS: We retrospectively evaluated BMD of subjects screened for lung trans ... Full text Link to item Cite

Construct validity of the definition of primary graft dysfunction after lung transplantation.

Journal article J Heart Lung Transplant · November 2010 BACKGROUND: This study tested the discriminant validity of International Society for Heart and Lung Transplantation (ISHLT) primary graft dysfunction (PGD) grades with lung injury biomarker profiles and survival. METHODS: The study samples consisted of a m ... Full text Link to item Cite

Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients.

Journal article Am J Respir Crit Care Med · September 15, 2010 Featured Publication RATIONALE: Despite the importance of bronchiolitis obliterans syndrome (BOS) in lung transplantation, little is known regarding the factors that influence survival after the onset of this condition, particularly among bilateral transplant recipients. OBJEC ... Full text Link to item Cite

Gastroesophageal reflux and altered motility in lung transplant rejection.

Journal article Neurogastroenterol Motil · August 2010 Featured Publication BACKGROUND: Lung transplantation has become an effective therapeutic option for selected patients with end stage lung disease. Long-term survival is limited by chronic rejection manifest as bronchiolitis obliterans syndrome (BOS). The aspiration of gastric ... Full text Link to item Cite

Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation.

Journal article Am J Respir Crit Care Med · June 15, 2010 Featured Publication RATIONALE: Cytomegalovirus pneumonitis is one of the most prevalent opportunistic infections after lung transplantation. Early studies reported that cytomegalovirus pneumonitis was a risk factor for chronic allograft dysfunction. More recently, in the era ... Full text Link to item Cite

Extended valganciclovir prophylaxis to prevent cytomegalovirus after lung transplantation: a randomized, controlled trial.

Journal article Ann Intern Med · June 15, 2010 Featured Publication BACKGROUND: Cytomegalovirus (CMV) is the most prevalent opportunistic infection after lung transplantation. Current strategies do not prevent CMV in most at-risk patients. OBJECTIVE: To determine whether extending prophylaxis with oral valganciclovir from ... Full text Link to item Cite

Lung transplantation in advanced COPD: is it worth it?

Journal article Semin Respir Crit Care Med · June 2010 Featured Publication Chronic obstructive pulmonary disease (COPD) is a condition of progressive airflow obstruction occurring primarily as a result of tobacco use that accounts for substantial worldwide morbidity and mortality. Medical therapy, with the exception of oxygen and ... Full text Link to item Cite

Acute cellular rejection and humoral sensitization in lung transplant recipients.

Journal article Semin Respir Crit Care Med · April 2010 Featured Publication Despite the recent development of many new immunosuppressive agents for use in transplantation, acute cellular and humoral rejection represent extremely prevalent and serious complications after lung transplantation. Acute cellular rejection, defined as pe ... Full text Link to item Cite