Scholars@Duke
Paloma Borrajo Liton

Paloma Borrajo Liton

Professor in Ophthalmology
Ophthalmology, Glaucoma
DUMC 3802, Durham, NC 27710
2351 Erwin Road, Aeri 4004, Durham, NC 27705

Featured Works

Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress.

Journal article Invest Ophthalmol Vis Sci · December 2010 Featured Publication PURPOSE: To investigate the role of intralysosomal redox-active iron in oxidative stress-induced damage in trabecular meshwork (TM) cells. METHODS: Chronic oxidative stress was applied using the hyperoxic model; acute oxidative stress was applied with H(2) ... Full text Link to item Cite

The role of proteolytic cellular systems in trabecular meshwork homeostasis.

Journal article Exp Eye Res · April 2009 Featured Publication The molecular mechanisms contributing to the progressive malfunction of the trabecular meshwork (TM)/Schlemm's canal (SC) conventional outflow pathway during aging and in Primary Open Angle Glaucoma (POAG) are still poorly understood. Progressive accumulat ... Full text Link to item Cite

Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma.

Journal article Autophagy · January 2009 Featured Publication Primary open angle glaucoma (POAG) is a late onset disease usually accompanied by elevated intraocular pressure (IOP) that results from the failure of the trabecular meshwork (TM) to maintain normal levels of aqueous humor outflow resistance. Cells in the ... Full text Link to item Cite

Cultured porcine trabecular meshwork cells display altered lysosomal function when subjected to chronic oxidative stress.

Journal article Invest Ophthalmol Vis Sci · September 2008 Featured Publication PURPOSE: To investigate the effects of chronic oxidative stress on lysosomal function in trabecular meshwork (TM) cells. METHODS: Confluent cultures of porcine TM cells were grown for 2 weeks in physiological (5% O(2)) or hyperoxic conditions (40% O(2)) in ... Full text Link to item Cite

Stress response of the trabecular meshwork.

Journal article J Glaucoma · August 2008 Featured Publication The trabecular meshwork (TM) is known to be subjected to different types of stress such as mechanical, oxidative, and phagocytic stress. Although short-term exposure to these stresses is expected to elicit adaptive responses, long-term exposure may lead to ... Full text Link to item Cite

Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue.

Journal article Mol Vis · July 12, 2006 Featured Publication PURPOSE: To contrast genome-wide gene expression profiles of cultured human trabecular meshwork (HTM) cells to that of control and primary open angle glaucoma (POAG) HTM tissues. METHODS: Cultured HTM cells, HTM tissue dissected from control donors, and HT ... Link to item Cite

Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro.

Journal article Exp Eye Res · June 2006 Featured Publication It has been observed in several tissues that direct isolation of cells in serum-free media and on nonadhesive substrates results in the formation of spherical clusters of cells known as free-floating spheres. Such free-floating spheres have been hypothesiz ... Full text Link to item Cite

Induction of TGF-beta1 in the trabecular meshwork under cyclic mechanical stress.

Journal article J Cell Physiol · December 2005 Featured Publication The pathophysiological mechanisms involved in the failure of the trabecular meshwork (TM) to maintain normal levels of aqueous outflow in glaucoma are not yet understood. Aberrant activation of the transforming growth factor beta-1 (TGF-beta1) pathway has ... Full text Link to item Cite

Cellular senescence in the glaucomatous outflow pathway.

Journal article Exp Gerontol · 2005 Featured Publication The mechanisms responsible for the progressive malfunction of the trabecular meshwork (TM)-Schlemm's canal (SC) conventional outflow pathway tissue in primary open angle glaucoma (POAG) are still not fully understood. To determine whether POAG is character ... Full text Link to item Cite

Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter.

Journal article Invest Ophthalmol Vis Sci · January 2005 Featured Publication PURPOSE: To compare the gene expression profile of trabecular meshwork (TM) and Schlemm's canal (SC) primary cultures and to identify promoters for targeting gene expression to specific cells in the outflow pathway. METHODS: The differential gene expressio ... Full text Link to item Cite