Scholars@Duke
Pamela Susan Douglas

Pamela Susan Douglas CV

Ursula Geller Distinguished Professor of Research in Cardiovascular Diseases
Medicine, Cardiology
Duke Box 17969, Durham, NC 27705
300 W. Morgan St Room 841, Durham, NC 27701
CV

Scholarly Works - Journal articles

Design and Rationale of the pERSonalized cardIovascuLar dIsease prEvention, treatmeNt, and CarE (RESILIENCE) study.

Journal article Contemp Clin Trials · August 2026 BACKGROUND: Obesity is a growing epidemic associated with cardiovascular disease (CVD). The RESILIENCE study aimed to understand the factors underlying heterogeneity in CVD development among individuals with obesity as well as the variability in response t ... Full text Link to item Cite

Proteomic Signatures of High-Risk Coronary Plaque Features and Incident Events.

Journal article JACC Basic Transl Sci · July 22, 2026 Patients with and without obstructive coronary artery disease (oCAD) experience heterogeneous cardiovascular risk, and coronary computed tomography angiography (CCTA) high-risk plaque features are not universally available. This study evaluated whether cir ... Full text Link to item Cite

Inflammatory, Cardiac, and Lipid-Related Biomarkers in Relation to Residual MACE Risk in the REPRIEVE Trial.

Journal article JACC Adv · July 10, 2026 BACKGROUND: Residual major adverse cardiovascular event (MACE) risk persists despite successful prevention of cardiovascular disease (CVD) with statin therapy among people with HIV (PWH). Identifying key biomarkers related to residual cardiovascular risk i ... Full text Link to item Cite

A Validated, Modifiable Proteomic Score from the EXSCEL Trial Predicts Cardiovascular Events in Diabetes.

Journal article JCI Insight · July 2, 2026 Adults with type 2 diabetes mellitus (T2DM) are at increased risk for stroke, myocardial infarction, and cardiovascular death, yet individual risk is heterogeneous and incompletely captured by clinical models. In the Exenatide Study of Cardiovascular Event ... Full text Link to item Cite

Biological, Radiological, and Clinical Significance of Spotty Calcification in Coronary Artery Disease.

Journal article JACC Cardiovasc Imaging · July 2026 Spotty calcification is a marker of microcalcification in coronary artery plaques, where it becomes large enough to be visible on imaging modalities such as computed tomography. Two prevailing hypotheses posit spotty calcification as either a passive indic ... Full text Link to item Cite

Pitavastatin effect on enterocyte injury markers in an ART treated HIV population: Insights from REPRIEVE.

Journal article AIDS · June 26, 2026 OBJECTIVE: To determine whether pitavastatin reduces enterocyte injury, assessed by intestinal fatty acid-binding protein (I-FABP), among antiretroviral therapy-treated people with HIV (PWH) enrolled in the REPRIEVE mechanistic substudy. DESIGN: Randomized ... Full text Link to item Cite

Association Between Predicting Risk of Cardiovascular Disease Events (PREVENT) Risk Scores and Subclinical Cardiovascular Disease: Insights From the Project Baseline Health Study.

Journal article J Am Heart Assoc · June 2, 2026 BACKGROUND: The American Heart Association Predicting Risk of Cardiovascular Disease Events risk scores estimate cardiovascular disease (CVD) risk, including heart failure (HF) and atherosclerotic CVD (ASCVD) events. Whether they associate with subclinical ... Full text Link to item Cite

Impact of the 2025 ASE Guidelines on the Classification of LV Diastolic Dysfunction in the Community: A Project Baseline Health Study.

Journal article Circ Cardiovasc Imaging · June 2026 BACKGROUND: The 2016 American Society of Echocardiography (ASE) guidelines for left ventricular diastolic dysfunction (LVDD) classification resulted in a significant proportion of indeterminate classifications and grades. To address these limitations and i ... Full text Link to item Cite

Hepatic Steatosis Is Associated With Increased Cardiovascular Risk Through Adverse Coronary Plaque Composition.

Journal article Clin Gastroenterol Hepatol · May 20, 2026 BACKGROUND & AIMS: Hepatic steatosis has been associated with major adverse cardiovascular events independently of other cardiovascular risk factors and the severity of coronary artery disease. Nevertheless, the relationship between hepatic steatosis, coro ... Full text Link to item Cite

Risk of obesity, diabetes, hypertension, and major adverse cardiovascular events after a switch to an integrase inhibitor: a target trial emulation in REPRIEVE.

Journal article Lancet HIV · May 2026 BACKGROUND: Integrase strand-transfer inhibitors (INSTIs) are linked to weight gain, but data on their cardiometabolic effects, particularly major adverse cardiovascular events (MACE), are scarce. We aimed to estimate the risk of obesity, diabetes, hyperte ... Full text Link to item Cite

Pitavastatin effects on lipids in relation to major adverse cardiovascular events: a REPRIEVE secondary analysis.

Journal article Lancet HIV · May 2026 BACKGROUND: The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) found a 36% reduction in major adverse cardiovascular events (MACE) with pitavastatin in people with HIV. Little is known about the relationship between lipid lowering and MACE i ... Full text Link to item Cite

Incidence, risk factors, and cardiovascular impact of hypertension in people with HIV: a secondary analysis of the REPRIEVE trial.

Journal article Lancet HIV · May 2026 BACKGROUND: People living with HIV have an increased risk of cardiovascular disease, but data on the development and consequences of hypertension remain limited. Using data from REPRIEVE, a global randomised trial of pitavastatin for primary cardiovascular ... Full text Link to item Cite

Messaging Modality and Content for Recruitment of Research Participants: A Randomized Clinical Trial.

Journal article JAMA Netw Open · May 1, 2026 IMPORTANCE: Optimizing participant recruitment is critical to the success and generalizability of clinical research, yet there is limited randomized clinical trial evidence comparing the effects of digital recruitment strategies and message framing on part ... Full text Link to item Cite

Aligning Coronary Stent Trial Enrollment With the U.S. Intended-Use Population: Implications of Site Selection.

Journal article J Am Coll Cardiol · April 28, 2026 BACKGROUND: Class III cardiovascular device premarket approval (PMA) studies often fail to fully represent the intended-use population (IUP) owing to low enrollment of racial and ethnic minority subjects and women. The impact of research site selection on ... Full text Link to item Cite

Health-related quality of life among people with HIV at low-to-moderate risk for atherosclerotic cardiovascular disease in the REPRIEVE Trial.

Journal article AIDS · April 1, 2026 BACKGROUND: There is limited evidence concerning the relationship between cardiometabolic characteristics and health-related quality of life (HRQoL), and potential effects of statin therapy among people with HIV (PWH). METHODS: The Randomized Trial to Prev ... Full text Link to item Cite

Statin Effects on Pericoronary Adipose Tissue Density in People With HIV: Insights From the REPRIEVE Trial.

Journal article JACC Cardiovasc Imaging · April 2026 BACKGROUND: The effects of statin therapy on pericoronary adipose tissue (PCAT) and its relationship with plaque progression and outcomes in people with HIV (PWH) remain poorly understood. OBJECTIVES: The aim of this study was to evaluate PCAT density chan ... Full text Link to item Cite

Heart Failure Risk and Events in People With HIV: The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE).

Journal article Circ Heart Fail · April 2026 BACKGROUND: People with HIV (PWH) may have a higher risk of heart failure (HF) due to traditional and HIV-related factors. Incidence and risk prediction of HF in PWH are not well characterized. We aimed to quantify the risk of HF events in a global populat ... Full text Link to item Cite

Unbiased Discovery of Genetic Determinants of Resilience to CAD: Insights From PROMISE and CATHGEN.

Journal article JACC Adv · April 2026 BACKGROUND: Genetic determinants of resilience remain poorly defined beyond family studies. OBJECTIVES: The purpose of this study was to perform an unbiased study of individuals with discordance between clinical/genetic risk and atherosclerotic burden to d ... Full text Link to item Cite

Audiovisual Augmentation of Electronic Consent to Improve Consent Rates and Comprehension: A Randomized Clinical Trial.

Journal article JAMA Netw Open · April 1, 2026 IMPORTANCE: The use of audiovisual aids in the consent process may improve comprehension and willingness to participate in research. However, data supporting this hypothesis are lacking. OBJECTIVE: To determine the impact of audiovisual augmentation of the ... Full text Link to item Cite

Incorporation of lipoprotein(a) levels improves calibration of pre-test likelihood estimates of obstructive coronary artery disease.

Journal article Eur Heart J Cardiovasc Imaging · March 27, 2026 AIMS: Risk factor-weighted clinical likelihood (RF-CL) estimates the probability of obstructive coronary artery disease (CAD) in patients without known CAD. We examined whether adding lipoprotein(a) [Lp(a)] measurements to the RF-CL model improves predicti ... Full text Link to item Cite

Validation of a novel scoring tool for assessment of the severity of coronary disease and ischaemia burden to predict major adverse cardiac events at 5 years in the 3V-FFR FRIENDS population.

Journal article Cardiovasc Revasc Med · March 2026 BACKGROUND: Ischaemic heart disease is the most prevalent form of cardiovascular disease (CVD) worldwide and imposes a substantial burden on healthcare systems. Identification of patients at high risk of events in a tailored primary prevention strategy is ... Full text Link to item Cite

Prognostic Value of Plaque Volume in Patients With First Diagnosis of Coronary Artery Disease: A Substudy of the PROMISE Randomized Clinical Trial.

Journal article JAMA Cardiol · March 1, 2026 IMPORTANCE: Despite the increasing use of coronary computed tomographic angiography (CCTA) in patients with known or suspected coronary artery disease (CAD), comparatively little is known about its predictive value for adverse events or clinical applicabil ... Full text Link to item Cite

Risk in Women Emerges at Lower Coronary Plaque Burden Than in Men: PROMISE Trial.

Journal article Circ Cardiovasc Imaging · March 2026 BACKGROUND: Quantitative coronary plaque measures differ in prognostic value between women and men. It remains unclear whether cardiovascular risk increases proportionally with plaque extent in both sexes. We aimed to compare cardiovascular risk trajectori ... Full text Link to item Cite

Risk Assessment in a Global CVD Prevention Cohort of People With HIV by PCE, PREVENT, and SCORE2.

Journal article Clin Infect Dis · February 25, 2026 BACKGROUND: REPRIEVE findings catalyzed changes to multiple guidelines directing statin therapy prescribing for people with HIV (PWH). US guidelines use the pooled cohort equation (PCE)-derived 10-year atherosclerotic cardiovascular disease (ASCVD) risk sc ... Full text Link to item Cite

Win Ratio Aligns With and Enhances Interpretation of REPRIEVE's Primary Findings.

Journal article Clin Infect Dis · February 9, 2026 We performed a win ratio (WR) analysis of REPRIEVE, a randomized trial of pitavastatin vs placebo for cardiovascular disease in people with human immunodeficiency virus to assess robustness to event severity. WR aligns with primary findings and provides in ... Full text Link to item Cite

Factors Affecting Risk of Cardiovascular Disease (CVD) Events in a Global CVD Prevention Cohort of People With HIV.

Journal article Clin Infect Dis · February 4, 2026 BACKGROUND: Persons with HIV face increased risks of major adverse cardiovascular events (MACE), partially mitigated by statin therapy. METHODS: We characterized factors associated with MACE and MACE subcomponents among PWH enrolled in REPRIEVE, globally. ... Full text Link to item Cite

Effect of Pitavastatin on Epigenetic Aging Biomarkers in People With HIV: Pilot Substudy of the REPRIEVE Trial.

Journal article Clin Infect Dis · February 4, 2026 BACKGROUND: People with human immunodeficiency virus (HIV, PWH) exhibit increased cardiovascular disease (CVD) risk and accelerated biological aging. REPRIEVE demonstrated that pitavastatin reduced major adverse cardiovascular events (MACE) in antiretrovir ... Full text Link to item Cite

The prevalence of carotid subclinical atherosclerosis according to age: A systematic review and meta-analysis of the young to middle-age.

Journal article J Clin Lipidol · February 2026 BACKGROUD: As the burden of atherosclerotic cardiovascular disease (ASCVD) continues to rise, knowing the prevalence of its subclinical form is essential for early risk stratification and prevention. This review investigated the prevalence of carotid subcl ... Full text Link to item Cite

The association of risk factors on coronary computed tomography angiography derived atherosclerotic plaque volume - Lessons from the ADVANCE registry.

Journal article Atherosclerosis · February 2026 BACKGROUND: Diabetes mellitus, smoking, hypertension, and hyperlipidemia are well-studied cardiovascular risk factors (CVRF) for coronary artery disease (CAD). However, their combined and individual influence on atherosclerotic total plaque volume (TPV) an ... Full text Link to item Cite

Clonal Hematopoiesis and Major Adverse Cardiac Events in People With HIV: Insights From the REPRIEVE Trial.

Journal article Arterioscler Thromb Vasc Biol · January 2026 BACKGROUND: People with HIV (PWH) experience higher cardiovascular disease event rates not fully explained by traditional risk factors. Clonal hematopoiesis of indeterminate potential (CHIP), an emerging risk factor for cardiovascular disease in the genera ... Full text Link to item Cite

Valvular Heart Disease Associations With Cardiac Biomarkers Using AI-Guided Echocardiography: The RURAL Cohort Study.

Journal article JACC Adv · January 2026 BACKGROUND: Few studies have evaluated the prevalence or severity of mitral valve prolapse (MVP) and other valvular heart disease (VHD) in the rural U.S. South, where strategies for early detection are crucial for risk stratification and prevention. OBJECT ... Full text Link to item Cite

Absence of significant coronary artery disease does not eliminate smoking-related cardiovascular risk: insights from the PROMISE trial

Journal article American Journal of Preventive Cardiology · January 1, 2026 Background: Although the relationship between smoking and cardiovascular events is well established, it remains uncertain whether the outcomes of noninvasive testing (NIT) influence this relationship and how systemic biomarkers may aid risk stratification ... Full text Cite

Design and Rationale of GPS-CAD: Global Pretest Probability Study of Coronary Artery Disease.

Journal article JACC Asia · December 30, 2025 BACKGROUND: Atherosclerotic coronary artery disease (ACAD) is a prevalent condition causing a significant number of deaths worldwide. Even though Asian and other non-Western regions are the main drivers of future increase, there are insufficient data on AC ... Full text Link to item Cite

Baseline ECG and Cardiovascular Outcomes in People With HIV: Insights From REPRIEVE.

Journal article J Am Heart Assoc · December 16, 2025 BACKGROUND: With antiretroviral therapy, people with HIV (PWH) have an increased burden of cardiovascular disease. The REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) trial demonstrated that pitavastatin reduces major adverse cardiovascular e ... Full text Link to item Cite

Spectrum of Perceptions Regarding Professional Climate: A National Survey of U.S. Cardiologists and Trainees.

Journal article JACC Adv · December 2025 BACKGROUND: Characterizations of cardiology's professional climate often focus on negative experiences. OBJECTIVES: The study's primary objective was to broadly characterize cardiology climate. METHODS: The American College of Cardiology surveyed 1805 card ... Full text Link to item Cite

Statin-dependent and -independent pathways are associated with major adverse cardiovascular events in people with HIV.

Journal article J Clin Invest · November 17, 2025 BACKGROUNDStatin therapy lowers the risk of major adverse cardiovascular events (MACE) among people with HIV (PWH). Residual risk pathways contributing to excess MACE beyond LDL-cholesterol (LDL-C) are not well understood. Our objective was to evaluate the ... Full text Link to item Cite

No evidence of pitavastatin effect on muscle area or density among people with HIV.

Journal article AIDS · November 15, 2025 BACKGROUND: Skeletal muscle area and muscle density are key determinants of physical function and typically decline with increasing age. Statins have well known musculoskeletal effects but whether statins impact muscle area or muscle density is not well es ... Full text Link to item Cite

No evidence of a detrimental effect of pitavastatin on neurocognitive function among people with HIV.

Journal article AIDS · November 1, 2025 OBJECTIVE: Effects of statins on neurocognitive function remain poorly understood, with some studies suggesting harm and others suggesting benefit. Limited observational data among people with HIV (PWH) is biased by indication for statin prescription. We s ... Full text Link to item Cite

Sex-specific prognostic value of automated epicardial adipose tissue quantification on serial lung cancer screening chest computed tomography.

Journal article Eur Heart J Cardiovasc Imaging · October 30, 2025 AIMS: Epicardial adipose tissue (EAT) is a metabolically active fat depot associated with coronary atherosclerosis and cardiovascular (CV) risk. While EAT is a known prognostic marker in lung cancer screening, its sex-specific prognostic value remains uncl ... Full text Link to item Cite

Risks for sudden cardiac and undetermined cause of death among people with HIV in the REPRIEVE primary cardiovascular prevention trial.

Journal article AIDS · October 1, 2025 OBJECTIVE: People with HIV (PWH) are at increased risk of sudden cardiac death (SCD) but the mechanisms are unclear limiting prevention efforts. We leveraged the global REPRIEVE trial with carefully adjudicated atherosclerotic cardiovascular disease (ASCVD ... Full text Link to item Cite

Survival After Initial Stress Testing vs Anatomic Testing in Suspected Coronary Artery Disease: Long-Term Follow-Up of the PROMISE Randomized Clinical Trial.

Journal article JAMA Cardiol · October 1, 2025 IMPORTANCE: Symptoms suggestive of coronary artery disease (CAD) often require noninvasive testing for diagnostic and prognostic evaluation. OBJECTIVE: To determine long-term outcomes in patients randomized to functional (stress) vs anatomic (coronary comp ... Full text Link to item Cite

Preserving and Promoting Clinical Trial Representativeness: A Review of Existing Strategies and the Path Forward.

Journal article JAMA Cardiol · September 1, 2025 IMPORTANCE: Despite major advancements in cardiovascular clinical research, underrepresentation in cardiovascular clinical trials persists, limiting generalizability, access to novel therapies, and equitable care. OBSERVATIONS: Policymakers, funding bodies ... Full text Link to item Cite

Frailty, Pitavastatin, and Major Adverse Cardiovascular Events Among People With HIV.

Journal article JACC Adv · September 2025 BACKGROUND: People with HIV (PWH) are at increased risk for atherosclerotic cardiovascular diseases (ASCVDs) and geriatric syndromes, including frailty. REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) demonstrated a 36% reduction in major adv ... Full text Link to item Cite

Dual probability approach for risk adjustment in patients with a low clinical likelihood of coronary artery disease.

Journal article Eur Heart J Cardiovasc Imaging · August 29, 2025 AIMS: To investigate whether the PROMISE Minimal Risk Score (PMRS) enables adjustment of the risk factor-weighted clinical likelihood of obstructive CAD. METHODS AND RESULTS: Two cohorts of stable patients with new-onset chest pain were established: a diag ... Full text Link to item Cite

Impact of Coronary Artery Disease on Cardiovascular Outcomes Differs Between Men and Women With Severe Aortic Stenosis.

Journal article Circ Cardiovasc Interv · August 2025 BACKGROUND: There is heterogeneity in coronary artery disease (CAD) severity among individuals with severe aortic stenosis (AS), but whether this differentially influences prognosis is unknown. METHODS: Patients with severe AS in the PARTNER 1, 2, and 3 tr ... Full text Link to item Cite

Accelerating Drug Translation: Role of Coronary Computed Tomography Angiography Plaque Imaging Candidates as Surrogate Biomarkers.

Journal article JACC Cardiovasc Imaging · August 2025 There is an unmet need for new pathways to evaluate therapeutic targets and drugs for coronary artery disease (CAD). The use of major adverse cardiovascular events as a primary outcome is advantageous for rigor, but challenges related to large sample size ... Full text Link to item Cite

Effects of antiretrovirals on major adverse cardiovascular events in the REPRIEVE trial: a longitudinal cohort analysis.

Journal article Lancet HIV · July 2025 BACKGROUND: In the REPRIEVE trial of statin therapy in people with HIV, pitavastatin reduced major adverse cardiovascular events (MACE) among those with low-to-moderate risk of cardiovascular disease (CVD). We aimed to investigate associations between form ... Full text Link to item Cite

Returning Individual-Level Urgent or Emergent Research Results to Participants: The Project Baseline Health Study Experience.

Journal article Am J Med Open · June 2025 BACKGROUND: Returning results to research participants is increasingly recognized as an ethical mandate, yet little is known about best practices to optimally communicate urgent or emergent results. METHODS: We describe the development of and experience wi ... Full text Link to item Cite

Coronary Plaque, Inflammation, Subclinical Myocardial Injury, and Major Adverse Cardiovascular Events in the REPRIEVE Substudy.

Journal article JACC Adv · June 2025 BACKGROUND: In REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV), pitavastatin prevented major adverse cardiovascular events (MACE) and reduced noncalcified coronary plaque (NCP) among people with HIV and low-to-moderate traditional cardiovascu ... Full text Link to item Cite

Prognostic Factors of Physical Function Decline Among Middle-Aged Adults With HIV.

Journal article Open Forum Infect Dis · June 2025 BACKGROUND: Pitavastatin to REduce Physical Function Impairment and FRailty in HIV (PREPARE) found small declines in physical function overall among people with HIV (PWH). However, there was substantial individual variability. The purpose of this prespecif ... Full text Link to item Cite

Clinical likelihood models calibrated against observed obstructive coronary artery disease on computed tomography angiography.

Journal article Eur Heart J Cardiovasc Imaging · April 30, 2025 AIMS: Models predicting the likelihood of obstructive coronary artery disease (CAD) on invasive coronary angiography exist. However, as stable patients with new-onset chest pain frequently have lower clinical likelihood and preferably undergo index testing ... Full text Link to item Cite

Cardiovascular Hazards of Abacavir- Versus Tenofovir-Containing Antiretroviral Therapies: Insights From an Analysis of the REPRIEVE Trial Cohort.

Journal article Open Forum Infect Dis · April 2025 BACKGROUND: Prior analyses suggest that the nucleoside reverse transcriptase inhibitor (NRTI) abacavir (ABC), but not tenofovir (TFV), is associated with a 2-fold increase in the hazard of myocardial infarction. the Randomized Trial to Prevent Vascular Eve ... Full text Link to item Cite

Workplace Mistreatment in U.S. Cardiology: A Comprehensive Analysis of Experiences and Implications.

Journal article JACC Adv · April 2025 BACKGROUND: Discrimination and harassment are common in cardiology but data on its impact are limited. OBJECTIVES: This study sought to identify the prevalence and impact of workplace mistreatment among U.S. cardiologists overall and when engaged in clinic ... Full text Link to item Cite

Statin effects on the incidence of major non-cardiovascular disease events among a global cohort of people with HIV: a randomised controlled trial.

Journal article Lancet HIV · April 2025 BACKGROUND: Given the pleiotropic effects of statins beyond lipid-lowering, statins might positively impact other, non-cardiovascular diseases (non-CVDs). In this study, we prospectively assessed statin effects on non-CVD events and their incidence among p ... Full text Link to item Cite

Association between polysocial risk score and CVH among women of reproductive age in the SAFE HEART study: An American Heart Association Research Goes Red Initiative.

Journal article Curr Probl Cardiol · March 2025 BACKGROUND: To assess the association between polysocial risk factors and cardiovascular health (CVH) among women of reproductive age. METHODS: Our cross-sectional analysis included women of reproductive age (18-44 years) from community settings and the Am ... Full text Link to item Cite

Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV: A Secondary Analysis of the REPRIEVE Randomized Clinical Trial.

Journal article JAMA Cardiol · March 1, 2025 IMPORTANCE: In a mechanistic substudy of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) randomized clinical trial, pitavastatin reduced noncalcified plaque (NCP) volume, but specific protein and gene pathways contributing to changes in c ... Full text Link to item Cite

Representation of Women Among Cardiology Grand Rounds Speakers in the United States.

Journal article JAMA Cardiol · March 1, 2025 IMPORTANCE: Women are underrepresented in leadership positions in cardiology. Institutional grand rounds (GR) are platforms through which faculty can gain professional exposure and access to career development opportunities. The gender diversity of invited ... Full text Link to item Cite

Pitavastatin Is Well-Tolerated With no Detrimental Effects on Physical Function.

Journal article Clin Infect Dis · February 24, 2025 BACKGROUND: Little is known about the potential benefits or harms of statins on physical function among people with human immunodeficiency virus (PWH). METHODS: REPRIEVE was a double-blind randomized controlled trial evaluating pitavastatin for primary pre ... Full text Link to item Cite

Sex Differences in Computed Tomography Coronary Stenosis Severity Versus Flow Impairment and Impact on Revascularization, Clinical Events and Health Care Costs: A FORECAST Substudy.

Journal article J Am Heart Assoc · February 4, 2025 BACKGROUND: The impact of sex-related differences in coronary atheroma and flow impairment severity on clinical events and costs remains unclear. METHODS AND RESULTS: This is a secondary analysis of patients with stable coronary artery disease who underwen ... Full text Link to item Cite

Clinical risk prediction, coronary computed tomography angiography, and cardiovascular events in new-onset chest pain: the PROMISE and SCOT-HEART trials.

Journal article Eur Heart J · February 3, 2025 BACKGROUND AND AIMS: Whether index testing using coronary computed tomography angiography (CTA) improves outcomes in stable chest pain is debated. The risk factor weighted clinical likelihood (RF-CL) model provides likelihood estimation of obstructive coro ... Full text Link to item Cite

Coronary Artery Disease and Major Adverse Cardiovascular Events in People With Hepatic Steatosis at Low Atherosclerotic Cardiovascular Disease Risk.

Journal article Aliment Pharmacol Ther · February 2025 BACKGROUND: Hepatic steatosis (HS) and 10-year atherosclerotic cardiovascular disease (ASCVD) risk ≥ 7.5% are associated with increased risk for cardiovascular events. AIM: To assess underlying coronary artery disease (CAD) and major adverse cardiovascular ... Full text Link to item Cite

Sex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI.

Journal article JACC Adv · February 2025 BACKGROUND: Randomized controlled trials (RCTs) have examined the clinical impact of abbreviating the duration of dual antiplatelet therapy (DAPT) and have reported outcomes in men and women. OBJECTIVES: The authors examined the safety and efficacy of diff ... Full text Link to item Cite

Abnormal Exercise Electrocardiography With Normal Stress Echocardiography Is Associated With Subclinical Coronary Atherosclerosis.

Journal article Circ Cardiovasc Imaging · February 2025 BACKGROUND: Patients with abnormal (positive) exercise electrocardiography, but normal stress echocardiography (+ECG/-Echo), have an increased risk of adverse cardiovascular events compared with patients with a normal (negative) ECG and a normal stress Ech ... Full text Link to item Cite

Performance of the pooled cohort equations and D:A:D risk scores among individuals with HIV in a global cardiovascular disease prevention trial: a cohort study leveraging data from REPRIEVE.

Journal article Lancet HIV · February 2025 BACKGROUND: Risk estimation is an essential component of cardiovascular disease prevention among people with HIV. We aimed to characterise how well atherosclerotic cardiovascular disease (ASCVD) risk scores used in clinical guidelines perform among people ... Full text Link to item Cite

Economic Outcomes With Precision Diagnostic Testing Versus Usual Testing in Stable Chest Pain: Results From the PRECISE Randomized Trial.

Journal article Circ Cardiovasc Qual Outcomes · February 2025 BACKGROUND: The PRECISE (Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization) demonstrated that a precision diagnostic strategy reduced the primary composite of death, nonfatal myocardial infarction, or catheter ... Full text Link to item Cite

Quality of Life Outcomes With a Risk-Based Precision Testing Strategy Versus Usual Testing in Stable Patients With Suspected Coronary Disease: Results From the PRECISE Randomized Trial.

Journal article Circ Cardiovasc Qual Outcomes · February 2025 BACKGROUND: The PRECISE (Prospective Randomized Trial of the Optimal Evaluation of Cardiac Symptoms and Revascularization) trial compared an investigational precision diagnostic testing strategy (n=1057) with usual testing (n=1046) in patients with stable ... Full text Link to item Cite

Proteinuria and albuminuria among a global primary cardiovascular disease prevention cohort of people with HIV.

Journal article AIDS · January 1, 2025 OBJECTIVES: To determine baseline prevalence of proteinuria and albuminuria among participants from the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) and evaluate associated risk factors. DESIGN: Cross sectional analysis of a baseline sampl ... Full text Link to item Cite

Association between symptom characteristics and disease severity in patients suspected of coronary artery disease.

Journal article J Cardiovasc Comput Tomogr · 2025 BACKGROUND: Discrepancies often exist between patient-reported symptoms and diagnostic test findings in patients with suspected obstructive coronary artery disease (CAD). OBJECTIVES: To quantify the association between patient-reported symptoms and the dia ... Full text Link to item Cite

Sex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention.

Journal article Proc (Bayl Univ Med Cent) · 2025 BACKGROUND: Previous studies have reported worse outcomes in women following percutaneous coronary intervention (PCI), but contemporary studies examining sex differences in in-hospital outcomes and 90-day readmission risk are lacking. Therefore, we sought ... Full text Link to item Cite

Air pollution, coronary artery disease, and cardiovascular events: Insights from the PROMISE trial.

Journal article J Cardiovasc Comput Tomogr · 2025 BACKGROUND: Air pollution is associated with mortality and major adverse cardiovascular events (MACE) in the general population. However, little is known about the relationship between air pollution and coronary artery disease (CAD) and how this relates to ... Full text Link to item Cite

Association Between Lipoprotein(a) and Obstructive Coronary Artery Disease and High-Risk Plaque: Insights From the PROMISE Trial.

Journal article Am J Cardiol · November 15, 2024 The role of lipoprotein (a) (Lp[a]) in the development of obstructive coronary artery disease (CAD) and high-risk plaque (HRP) in primary prevention patients with stable chest pain is unknown. We sought to evaluate the relation of Lp(a), independent of low ... Full text Link to item Cite

Real-world walking behaviors are associated with early-stage heart failure: a Project Baseline Health Study.

Journal article J Card Fail · November 2024 BACKGROUND: Data collected via wearables may complement in-clinic assessments to monitor subclinical heart failure (HF). OBJECTIVES: Evaluate the association of sensor-based digital walking measures with HF stage and characterize their correlation with in- ... Full text Link to item Cite

Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention : A Randomized Trial.

Journal article Ann Intern Med · November 2024 BACKGROUND: REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) led to new guidelines for statin use among people with HIV (PWH) with low to moderate risk for atherosclerotic cardiovascular disease (ASCVD). Little is known about the natural histo ... Full text Link to item Cite

Effects of Pitavastatin on COVID-19 Incidence and Seriousness Among a Global Cohort of People With HIV.

Journal article Open Forum Infect Dis · October 2024 BACKGROUND: Among people with HIV (PWH), COVID-19 is common and potentially severe. We leveraged REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) to assess the effects of statin therapy for cardiovascular disease prevention on COVID-19 outcome ... Full text Link to item Cite

Work Environment, Burnout, and Intent to Leave Current Job Among Cardiologists and Cardiology Health Care Workers: Results From the National Coping With COVID Survey.

Journal article J Am Heart Assoc · September 17, 2024 BACKGROUND: Little is known about factors contributing to burnout and intent to leave in cardiologists and other cardiology health care workers. METHODS AND RESULTS: The Coping With COVID survey assessed work conditions, burnout, and intent to leave among ... Full text Link to item Cite

Design and rationale of the social determinants of the risk of hypertension in women of reproductive age (SAFE HEART) study: An American Heart Association research goes red initiative.

Journal article Am Heart J · September 2024 BACKGROUND: Cardiovascular health literacy (CVHL) and social determinants of health (SDoH) play interconnected and critical roles in shaping cardiovascular health (CVH) outcomes. However, awareness of CVH risk has declined markedly, from 65% of women being ... Full text Link to item Cite

Association of Cardiac Troponin T With Coronary Atherosclerosis in Asymptomatic Primary Prevention People With HIV.

Journal article JACC Adv · September 2024 BACKGROUND: Coronary plaque is common among people with HIV (PWH) with low-to-moderate traditional atherosclerotic cardiovascular disease (ASCVD) risk. OBJECTIVES: The purpose of this study was to determine the association of high-sensitivity cardiac tropo ... Full text Link to item Cite

Cardiovascular Risk Profile Among Reproductive-Aged Women in the U.S.: The Behavioral Risk Factor Surveillance System, 2015-2020.

Journal article AJPM Focus · August 2024 INTRODUCTION: Suboptimal cardiovascular health is associated with adverse pregnancy outcomes and long-term cardiovascular risk. The authors examined trends in cardiovascular risk factors and correlates of suboptimal cardiovascular risk profiles among repro ... Full text Link to item Cite

Evaluating the American Heart Association/American College of Cardiology Guideline-Recommended and Contemporary Pretest Probability Models in a Mixed Asian Cohort: The Contribution of Coronary Artery Calcium.

Journal article J Am Heart Assoc · July 2, 2024 BACKGROUND: Most pretest probability (PTP) tools for obstructive coronary artery disease (CAD) were Western -developed. The most appropriate PTP models and the contribution of coronary artery calcium score (CACS) in Asian populations remain unknown. In a m ... Full text Link to item Cite

Foreword

Journal article Cardiac Imaging in Structural Heart Disease Interventions A Textbook for the Heart Team · June 20, 2024 Cite

Geographic Mapping of Gender Disparities in Authorship of Cardiovascular Literature.

Journal article J Am Coll Cardiol · June 18, 2024 BACKGROUND: Women in cardiology experience considerable gender disparities in publications, which hinders their career advancements to higher faculty and senior leadership positions. However, the extent of these disparities across different types of cardio ... Full text Link to item Cite

Impact of smoking in patients with suspected coronary artery disease in the randomised DISCHARGE trial.

Journal article Eur Radiol · June 2024 OBJECTIVES: To investigate if the effect of cardiac computed tomography (CT) vs. invasive coronary angiography (ICA) on cardiovascular events differs based on smoking status. MATERIALS AND METHODS: This pre-specified subgroup analysis of the pragmatic, pro ... Full text Link to item Cite

Calcium Scoring Improves Clinical Management in Patients With Low Clinical Likelihood of Coronary Artery Disease.

Journal article JACC Cardiovasc Imaging · June 2024 BACKGROUND: Coronary artery calcium scoring (CACS) improves management of chest pain patients. However, it is unknown whether the benefit of CACS is dependent on the clinical likelihood (CL). OBJECTIVES: This study aims to investigate for which patients CA ... Full text Link to item Cite

Coronary Plaque in People With HIV vs Non-HIV Asymptomatic Community and Symptomatic Higher-Risk Populations.

Journal article JACC Adv · June 2024 BACKGROUND: People with HIV (PWH) have a high burden of coronary plaques; however, the comparison to people without known HIV (PwoH) needs clarification. OBJECTIVES: The purpose of this study was to determine coronary plaque burden/phenotype in PWH vs PwoH ... Full text Link to item Cite

Lipoprotein subclasses are associated with Hepatic steatosis: insights from the prospective multicenter imaging study for the evaluation of chest pain (PROMISE) clinical trial.

Journal article Am J Prev Cardiol · June 2024 OBJECTIVES: To determine the relationship between lipoprotein particle size/number with hepatic steatosis (HS), given its association with traditional lipoproteins and coronary atherosclerosis. METHODS: Individuals with available CT data and blood samples ... Full text Link to item Cite

Personalized Intervention Based on Early Detection of Atherosclerosis: JACC State-of-the-Art Review.

Journal article J Am Coll Cardiol · May 28, 2024 Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide and challenges the capacity of health care systems globally. Atherosclerosis is the underlying pathophysiological entity in two-thirds of patients with CVD. When co ... Full text Link to item Cite

Cytomegalovirus IgG is Associated With Physical Function But Not Muscle Density in People With HIV.

Journal article J Acquir Immune Defic Syndr · April 15, 2024 BACKGROUND: Cytomegalovirus (CMV) seropositivity is associated with poor outcomes, including physical function impairment, in people without HIV. We examined associations between CMV IgG titer and physical function in virologically suppressed people with H ... Full text Link to item Cite

Polygenic Scores and Preclinical Cardiovascular Disease in Individuals With HIV: Insights From the REPRIEVE Trial.

Journal article J Am Heart Assoc · April 2, 2024 BACKGROUND: Coronary artery disease (CAD) is a leading cause of death among the 38.4 million people with HIV globally. The extent to which cardiovascular polygenic risk scores (PRSs) derived in non-HIV populations generalize to people with HIV is not well ... Full text Link to item Cite

Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV: Mechanistic Substudy of the REPRIEVE Randomized Clinical Trial.

Journal article JAMA Cardiol · April 1, 2024 IMPORTANCE: Cardiovascular disease (CVD) is increased in people with HIV (PWH) and is characterized by premature noncalcified coronary plaque. In the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE), pitavastatin reduced major adverse cardiova ... Full text Link to item Cite

Comparing Costs of Noninvasive Cardiac Diagnostic Tests-a Population-Based Study.

Journal article J Am Soc Echocardiogr · March 2024 INTRODUCTION: Noninvasive cardiac diagnostic tests (NITs) for the diagnosis of coronary artery disease have been estimated to cost >$3 billion annually in the United States alone and have recently undergone scrutiny over concerns of overuse. Consequently, ... Full text Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Open Access Link to item Cite

Recruiting a Diverse Cardiology Physician Workforce.

Journal article JAMA Cardiol · March 1, 2024 IMPORTANCE: Understanding trends in the representation of women and individuals from underrepresented racial and ethnic populations in cardiovascular disease and cardiovascular subspecialty fellowships is essential to improving the diversity of the cardiol ... Full text Link to item Cite

Development of physiologically-informed computational coronary artery plaques for use in virtual imaging trials.

Journal article Med Phys · March 2024 BACKGROUND: As a leading cause of death, worldwide, cardiovascular disease is of great clinical importance. Among cardiovascular diseases, coronary artery disease (CAD) is a key contributor, and it is the attributed cause of death for 10% of all deaths ann ... Full text Link to item Cite

Effect of Sex and Flow Status on Outcomes After Surgical or Transcatheter Aortic Valve Replacement.

Journal article JACC Adv · March 2024 BACKGROUND: Low stroke volume index <35 ml/m2 despite preserved ejection fraction (paradoxical low flow [PLF]) is associated with adverse outcomes in patients with aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) or surgical aortic ... Full text Link to item Cite

Interaction of AI-Enabled Quantitative Coronary Plaque Volumes on Coronary CT Angiography, FFRCT, and Clinical Outcomes: A Retrospective Analysis of the ADVANCE Registry.

Journal article Circ Cardiovasc Imaging · March 2024 BACKGROUND: Luminal stenosis, computed tomography-derived fractional-flow reserve (FFRCT), and high-risk plaque features on coronary computed tomography angiography are all known to be associated with adverse clinical outcomes. The interactions between the ... Full text Link to item Cite

Risk factors for clonal hematopoiesis of indeterminate potential in people with HIV: a report from the REPRIEVE trial.

Journal article Blood Adv · February 27, 2024 Clonal hematopoiesis of indeterminate potential (CHIP), the clonal expansion of myeloid cells with leukemogenic mutations, results in increased coronary artery disease (CAD) risk. CHIP is more prevalent among people with HIV (PWH), but the risk factors are ... Full text Open Access Link to item Cite

Multimodality Cardiac Imaging and the Imaging Workforce in the United States: Diversity, Disparities, and Future Directions.

Journal article Circ Cardiovasc Imaging · February 2024 Innovations in cardiac imaging have fundamentally advanced the understanding and treatment of cardiovascular disease. These advances in noninvasive cardiac imaging have also expanded the role of the cardiac imager and dramatically increased the demand for ... Full text Link to item Cite

Closing the Last Mile Gap in Access to Multimodality Imaging in Rural Settings: Design of the Imaging Core of the Risk Underlying Rural Areas Longitudinal Study.

Journal article Circ Cardiovasc Imaging · February 2024 Achieving optimal cardiovascular health in rural populations can be challenging for several reasons including decreased access to care with limited availability of imaging modalities, specialist physicians, and other important health care team members. The ... Full text Link to item Cite

Derivation and validation of a novel functional FFRCT score incorporating the burden of coronary stenosis severity and flow impairment to predict clinical events.

Journal article J Cardiovasc Comput Tomogr · 2024 BACKGROUND: A score combining the burden of stenosis severity on coronary computed tomography angiography (CCTA) and flow impairment by fractional flow reserve derived from computed tomography (FFRCT) may be a better predictor of clinical events than eithe ... Full text Link to item Cite

Computed tomographic angiography measures of coronary plaque in clinical trials: opportunities and considerations to accelerate drug translation.

Journal article Front Cardiovasc Med · 2024 Atherosclerotic coronary artery disease (CAD) is the causal pathological process driving most major adverse cardiovascular events (MACE) worldwide. The complex development of atherosclerosis manifests as intimal plaque which occurs in the presence or absen ... Full text Link to item Cite

Pericoronary Adipose Tissue Density, Inflammation, and Subclinical Coronary Artery Disease Among People With HIV in the REPRIEVE Cohort.

Journal article Clin Infect Dis · December 15, 2023 BACKGROUND: Pericoronary adipose tissue (PCAT) may influence plaque development through inflammatory mechanisms. We assessed PCAT density, as a measure of pericoronary inflammation, in relationship to coronary plaque among people with human immunodeficienc ... Full text Link to item Cite

Pitavastatin and Cardiovascular Disease in HIV. Reply.

Journal article N Engl J Med · November 23, 2023 Full text Link to item Cite

Pitavastatin and Cardiovascular Disease in HIV.

Journal article N Engl J Med · November 23, 2023 Full text Link to item Cite

Hepatic steatosis and nonalcoholic fatty liver disease are common and associated with cardiometabolic risk in a primary prevention cohort of people with HIV.

Journal article AIDS · November 15, 2023 BACKGROUND: Hepatic steatosis, including nonalcoholic fatty liver disease (NAFLD), is common among people with HIV (PWH). We present baseline steatosis prevalence and cardiometabolic characteristics among REPRIEVE substudy participants. METHODS: REPRIEVE i ... Full text Link to item Cite

Clinical and Echocardiographic Diversity Associated With Physical Fitness in the Project Baseline Health Study: Implications for Heart Failure Staging.

Journal article J Card Fail · November 2023 BACKGROUND: Clinical and echocardiographic features may carry diverse information about the development of heart failure (HF). Therefore, we determined heterogeneity in clinical and echocardiographic phenotypes and its association with exercise capacity. M ... Full text Link to item Cite

Associations of Muscle Density and Area With Coronary Artery Plaque and Physical Function.

Journal article J Acquir Immune Defic Syndr · October 1, 2023 OBJECTIVE: Skeletal muscle quality and mass are important for maintaining physical function during advancing age. We leveraged baseline data from Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) to evaluate whether paraspinal muscle density an ... Full text Link to item Cite

Comparison of an Initial Risk-Based Testing Strategy vs Usual Testing in Stable Symptomatic Patients With Suspected Coronary Artery Disease: The PRECISE Randomized Clinical Trial.

Journal article JAMA Cardiol · October 1, 2023 IMPORTANCE: Trials showing equivalent or better outcomes with initial evaluation using coronary computed tomography angiography (cCTA) compared with stress testing in patients with stable chest pain have informed guidelines but raise questions about overte ... Full text Link to item Cite

Deferred Testing in Stable Outpatients With Suspected Coronary Artery Disease: A Prespecified Secondary Analysis of the PRECISE Randomized Clinical Trial.

Journal article JAMA Cardiol · October 1, 2023 IMPORTANCE: Guidelines recommend deferral of testing for symptomatic people with suspected coronary artery disease (CAD) and low pretest probability. To our knowledge, no randomized trial has prospectively evaluated such a strategy. OBJECTIVE: To assess pr ... Full text Link to item Cite

Biological and Clinical Implications of the Vascular Endothelial Growth Factor Coreceptor Neuropilin-1 in Human Immunodeficiency Virus.

Journal article Open Forum Infect Dis · October 2023 Plasma vascular endothelial growth factor (VEGF) coreceptor neuropilin-1 (NRP-1) had the largest association with coronary plaque in the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) proteomics analysis. With little known about NRP-1 in peo ... Full text Link to item Cite

Impact of Coronary CT Angiography-derived Fractional Flow Reserve on Downstream Management and Clinical Outcomes in Individuals with and without Diabetes.

Journal article Radiol Cardiothorac Imaging · October 2023 PURPOSE: To compare the clinical use of coronary CT angiography (CCTA)-derived fractional flow reserve (FFR) in individuals with and without diabetes mellitus (DM). MATERIALS AND METHODS: This secondary analysis included participants (enrolled July 2015 to ... Full text Link to item Cite

5-Year Prospective Evaluation of Mitral Valve-in-Valve, Valve-in-Ring, and Valve-in-MAC Outcomes: MITRAL Trial Final Results.

Journal article JACC Cardiovasc Interv · September 25, 2023 BACKGROUND: The MITRAL (Mitral Implantation of Transcatheter Valves) trial is the first prospective trial to evaluate the safety and feasibility of balloon-expandable aortic transcatheter heart valves in patients with failed surgical bioprostheses or annul ... Full text Link to item Cite

Pitavastatin to Prevent Cardiovascular Disease in HIV Infection.

Journal article N Engl J Med · August 24, 2023 BACKGROUND: The risk of cardiovascular disease is increased among persons with human immunodeficiency virus (HIV) infection, so data regarding primary prevention strategies in this population are needed. METHODS: In this phase 3 trial, we randomly assigned ... Full text Link to item Cite

Prognostic value of CT-derived coronary artery disease characteristics varies by ASCVD risk: insights from the PROMISE trial.

Journal article Eur Radiol · July 2023 OBJECTIVES: To compare the prognostic value of individual CT-derived coronary artery disease (CAD) characteristics across categories of clinical cardiovascular risk. METHODS: The central core laboratory assessed coronary artery calcium (CAC), obstructive C ... Full text Link to item Cite

Clinical and cost implications of deferred testing in low-risk patients with stable chest pain: a simulation using the PROMISE trial.

Journal article Am Heart J · July 2023 Current guidelines recommend a deferred testing approach in low-risk patients presenting with stable chest pain. After simulating a deferred testing approach using the PROMISE Minimal Risk Score to identify 915 minimal risk participants with cost data from ... Full text Link to item Cite

Changes in Body Mass Index with Longer-term Integrase Inhibitor Use: A Longitudinal Analysis of Data from the Randomized Trial to Prevent Vascular Events in Human Immunodeficiency Virus (REPRIEVE).

Journal article Clin Infect Dis · June 8, 2023 Over 2-years of follow-up, integrase strand transfer inhibitor (INSTI)-use was associated with weight gain among those on an INSTI <2 years at entry (+0.27 kg/m2/year; 95% confidence interval [CI], .22 to .33 vs +0.17 kg/m2/year; 95% CI, .12 to .23; P = .0 ... Full text Link to item Cite

Branched-Chain Amino Acids in Computed Tomography-Defined Adipose Depots and Coronary Artery Disease: A PROMISE Trial Biomarker Substudy.

Journal article J Am Heart Assoc · June 6, 2023 Background The interplay between branched-chain amino acid (BCAA) metabolism, an important pathway in adiposity and cardiometabolic disease, and visceral adipose depots such as hepatic steatosis (HS) and epicardial adipose tissue is unknown. We leveraged t ... Full text Link to item Cite

Variation in resource utilization and mortality among patients with varying MR type and severity.

Journal article Am Heart J · June 2023 BACKGROUND: Limited data exists regarding the relationships between resource use and outcomes in patients with mitral regurgitation (MR). We examined resource utilization and outcomes across MR type and severity. METHODS: Using the Duke Echocardiography La ... Full text Link to item Cite

Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy.

Journal article Circ Genom Precis Med · June 2023 BACKGROUND: Epigenetic clocks estimate chronologic age using methylation levels at specific loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal values in a range of clinical, imaging, and laboratory characteristics. ... Full text Link to item Cite

Diagnostic Strategies for the Assessment of Suspected Stable Coronary Artery Disease : A Systematic Review and Meta-analysis.

Journal article Ann Intern Med · June 2023 BACKGROUND: There is uncertainty about which diagnostic strategy for detecting coronary artery disease (CAD) provides better outcomes. PURPOSE: To compare the effect on clinical management and subsequent health effects of alternative diagnostic strategies ... Full text Link to item Cite

Influence of Obesity on Coronary Artery Disease and Clinical Outcomes in the ADVANCE Registry.

Journal article Circ Cardiovasc Imaging · May 2023 BACKGROUND: The relationship between body size and cardiovascular events is complex. This study utilized the ADVANCE (Assessing Diagnostic Value of Noninvasive FFRCT in Coronary Care) Registry to investigate the association between body mass index (BMI), c ... Full text Link to item Cite

Identification of pre-infection markers and differential plasma protein expression following SARS-CoV-2 infection in people living with HIV.

Journal article EBioMedicine · April 2023 BACKGROUND: Mechanisms contributing to COVID-19 severity in people with HIV (PWH) are poorly understood. We evaluated temporal changes in plasma proteins following SARS-CoV-2 infection and identified pre-infection proteomic markers associated with future C ... Full text Link to item Cite

Effect of host factors and COVID-19 infection on the humoral immune repertoire in treated HIV.

Journal article JCI Insight · March 8, 2023 People with HIV (PWH) appear to be at higher risk for suboptimal pathogen responses and for worse COVID-19 outcomes, but the effects of host factors and COVID-19 on the humoral repertoire remain unclear. We assessed the antibody isotype/subclass and Fc-rec ... Full text Link to item Cite

Contributions of Women to Cardiovascular Science Over Two Decades: Authorship, Leadership, and Mentorship.

Journal article J Am Heart Assoc · March 7, 2023 Background Women remain underrepresented in cardiology. We aimed to assess gender trends in research authorship, authorship in leading roles, mentorship, and research team diversity. Methods and Results We identified "cardiac and cardiovascular systems" jo ... Full text Link to item Cite

Relationship between obesity severity, metabolic status and cardiovascular disease in obese adults.

Journal article Eur J Clin Invest · March 2023 BACKGROUND: Evidence about the associations between obesity severity, metabolic status and risk of incident cardiovascular disease (CVD) in adults with obesity remains limited. METHODS: The study included 109,301 adults with obesity free of prior CVD based ... Full text Link to item Cite

Ideal cardiovascular health, biomarkers, and coronary artery disease in persons with HIV.

Journal article AIDS · March 1, 2023 OBJECTIVE: To investigate relationships between Life's Simple 7 (LS7), an assessment of cardiovascular health (CVH), and coronary plaque among people with HIV (PWH). DESIGN: Cross-sectional. METHODS: Coronary computed tomography angiography, immune/inflamm ... Full text Link to item Cite

Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus.

Journal article Open Forum Infect Dis · March 2023 BACKGROUND: Inflammasome activation is increased in people with human immunodeficiency virus (PWH), but its relationship with coronary plaque is poorly understood in this setting. METHODS: In a large human immunodeficiency virus cardiovascular prevention c ... Full text Link to item Cite

Prevalence and Professional Impact of Mental Health Conditions Among Cardiologists.

Journal article J Am Coll Cardiol · February 14, 2023 BACKGROUND: Mental illness among physicians is an increasingly recognized concern. Global data on mental health conditions (MHCs) among cardiologists are limited. OBJECTIVES: The purpose of this study was to investigate the global prevalence of MHCs among ... Full text Link to item Cite

Cytomegalovirus Immunoglobulin G (IgG) Titer and Coronary Artery Disease in People With Human Immunodeficiency Virus (HIV).

Journal article Clin Infect Dis · February 8, 2023 BACKGROUND: Cytomegalovirus (CMV) infection is thought to result in increased immune activation in people with human immunodeficiency virus (HIV, PWH). Although some data have linked asymptomatic CMV infection to cardiovascular disease among PWH, it remain ... Full text Link to item Cite

Sex Differences in Subclinical Atherosclerosis and Systemic Immune Activation/Inflammation Among People With Human Immunodeficiency Virus in the United States.

Journal article Clin Infect Dis · January 13, 2023 BACKGROUND: Among people with HIV (PWH), sex differences in presentations of atherosclerotic cardiovascular disease (ASCVD) may be influenced by differences in coronary plaque parameters, immune/inflammatory biomarkers, or relationships therein. METHODS: R ... Full text Link to item Cite

Lipoprotein Subclasses Associated With High-Risk Coronary Atherosclerotic Plaque: Insights From the PROMISE Clinical Trial.

Journal article J Am Heart Assoc · January 3, 2023 BACKGROUND More than half of major adverse cardiovascular events (MACE) occur in the absence of obstructive coronary artery disease and are often attributed to the rupture of high-risk coronary atherosclerotic plaque (HRP). Blood-based biomarkers that asso ... Full text Link to item Cite

Randomized comparison of chest pain evaluation with FFRCT or standard care: Factors determining US costs.

Journal article J Cardiovasc Comput Tomogr · 2023 BACKGROUND: FFRCT assesses the functional significance of lesions seen on CTCA, and may be a more efficient approach to chest pain evaluation. The FORECAST randomized trial found no significant difference in costs within the UK National Health Service, but ... Full text Link to item Cite

The importance of methods for site performance evaluation in REPRIEVE, a longitudinal, global, multicenter trial.

Journal article Contemp Clin Trials · January 2023 BACKGROUND: REPRIEVE, the Randomized Trial to Prevent Vascular Events in HIV, is a multicenter, primary prevention trial evaluating whether a statin can prevent major cardiovascular events in people with HIV. REPRIEVE is conducted at >100 clinical research ... Full text Link to item Cite

Clinical and Echocardiographic Characteristics of Flow-Based Classification Following Balloon-Expandable Transcatheter Heart Valve in PARTNER Trials.

Journal article JACC Cardiovasc Imaging · January 2023 BACKGROUND: Current expected normal echocardiographic measures of transcatheter heart valve (THV) function were derived from pooled cohorts of the randomized trials; however, THV function by flow state before or following transcatheter aortic valve replace ... Full text Link to item Cite

Discussion.

Journal article J Thorac Cardiovasc Surg · January 2023 Full text Link to item Cite

Opportunities and challenges to non-communicable disease (NCD) research and training in Pakistan: a qualitative study from Pakistan.

Journal article BMJ Open · December 19, 2022 INTRODUCTION: Most of the global non-communicable disease (NCD)-related death burden is borne by low and middle-income countries (LMICs). In LMICs like Pakistan, however, a major gap in responding to NCDs is a lack of high-quality research leading to polic ... Full text Link to item Cite

2-Year Outcomes of Transcatheter Mitral Valve Replacement in Patients With Annular Calcification, Rings, and Bioprostheses.

Journal article J Am Coll Cardiol · December 6, 2022 BACKGROUND: The MITRAL (Mitral Implantation of Transcatheter Valves) trial is the first prospective study for valve-in-mitral annular calcification (ViMAC), mitral valve-in-ring (MViR), and mitral valve-in-valve (MViV) using balloon-expandable aortic trans ... Full text Link to item Cite

Professional Preferences and Perceptions of Cardiology Among Internal Medicine Residents: Temporal Trends Over the Past Decade.

Journal article JAMA Cardiol · December 1, 2022 IMPORTANCE: Internal medicine residents' professional development preferences were discordant with their perceptions of cardiology in a survey circulated a decade ago; no contemporary data exist. This information is important for effective recruitment and ... Full text Link to item Cite

Risk factors for cardiovascular disease among individuals with hepatic steatosis.

Journal article Hepatol Commun · December 2022 Cardiovascular disease (CVD) is the leading cause of mortality in adults with hepatic steatosis (HS). However, risk factors for CVD in HS are unknown. We aimed to identify factors associated with coronary artery disease (CAD) and incident major adverse car ... Full text Link to item Cite

Earlier treatment in adults with high lifetime risk of cardiovascular diseases: What prevention trials are feasible and could change clinical practice? Report of a National Heart, Lung, and Blood Institute (NHLBI) Workshop.

Journal article Am J Prev Cardiol · December 2022 UNLABELLED: More than half of U.S. young adults have low ten-year but high lifetime risk of cardiovascular disease (CVD). Improving primary prevention in young adulthood may help reduce persistent CVD disparities and overall CVD morbidity and mortality. Th ... Full text Link to item Cite

Coronary Calcium Scoring Improves Risk Prediction in Patients With Suspected Obstructive Coronary Artery Disease.

Journal article J Am Coll Cardiol · November 22, 2022 BACKGROUND: In patients with suspected obstructive coronary artery disease (CAD), the risk factor-weighted clinical likelihood (RF-CL) model and the coronary artery calcium score-weighted clinical likelihood (CACS-CL) model improves the identification of o ... Full text Link to item Cite

Diet in a global cohort of adults with HIV at low-to-moderate traditional cardiovascular disease risk.

Journal article AIDS · November 15, 2022 OBJECTIVE: To characterize diet quality across a global cohort of people with HIV (PWH). DESIGN: Cross-sectional analysis. METHODS: Leveraging REPRIEVE data from baseline across five Global Burden of Disease (GBD) regions, we analyzed participant responses ... Full text Link to item Cite

Proteomic Signature of Subclinical Coronary Artery Disease in People With HIV: Analysis of the REPRIEVE Mechanistic Substudy.

Journal article J Infect Dis · November 11, 2022 BACKGROUND: People with HIV (PWH) have subclinical coronary artery disease (CAD) despite low traditional atherosclerotic cardiovascular disease (ASCVD) risk scores. Coronary plaque in PWH presents as a unique phenotype, but little is known about the contri ... Full text Link to item Cite

Implementing an anti-bullying culture in cardiology.

Journal article Nat Rev Cardiol · November 2022 Full text Link to item Cite

Factors Associated With Systemic Immune Activation Indices in a Global Primary Cardiovascular Disease Prevention Cohort of People With Human Immunodeficiency Virus on Antiretroviral Therapy.

Journal article Clin Infect Dis · October 12, 2022 BACKGROUND: Among antiretroviral therapy (ART)-treated people with human immunodeficiency virus (PWH), persistent systemic immune activation contributes to atherogenesis atherosclerotic, cardiovascular disease (CVD) events, and mortality. Factors associate ... Full text Link to item Cite

Associations of a polygenic risk score with coronary artery disease phenotypes in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Journal article Am Heart J · October 2022 A polygenic risk score (PGS) is associated with obstructive coronary artery disease (CAD) independent of traditional risk factors. Coronary computed tomography angiography (CTA) can characterize coronary plaques, including features of highrisk CAD. However ... Full text Link to item Cite

Global Differences in Parental Leave Policies and Satisfaction Among Cardiologists.

Journal article Curr Probl Cardiol · October 2022 Gender and regional differences in paid parental leave among cardiologists worldwide has not been documented. We investigated differences in paid parental leave policies globally. There are significant regional differences in parental leave among cardiolog ... Full text Link to item Cite

Geographical Differences in the Self-Reported Functional Impairment of People With Human Immunodeficiency Virus (HIV) and Associations With Cardiometabolic Risk.

Journal article Clin Infect Dis · September 30, 2022 BACKGROUND: We sought to explore multinational differences in functional status by global burden of disease (GBD) regions in the REPRIEVE cohort. METHODS: REPRIEVE is a prospective, double-blind, randomized, placebo-controlled, multicenter, phase III prima ... Full text Link to item Cite

Impact of Right Ventricle-Pulmonary Artery Coupling on Clinical Outcomes in the PARTNER 3 Trial.

Journal article JACC Cardiovasc Interv · September 26, 2022 BACKGROUND: Physiologic right ventricle-pulmonary artery (RV-PA) coupling may be impaired in patients with aortic stenosis (AS). OBJECTIVES: This study aimed to assess the incidence and prognostic significance of impaired RV-PA coupling in low-risk patient ... Full text Link to item Cite

Exploring ethnic representativeness in diabetes clinical trial enrolment from 2000 to 2020: a chronological survey.

Journal article Diabetologia · September 2022 AIMS/HYPOTHESIS: Ethnic representativeness of participant enrolment in diabetes RCTs involving multiple ethnicities remains unknown. The aims of this study were to evaluate the status and temporal trend of ethnic representativeness in enrolment to diabetes ... Full text Link to item Cite

Association Between Early Left Ventricular Ejection Fraction Improvement After Transcatheter Aortic Valve Replacement and 5-Year Clinical Outcomes.

Journal article JAMA Cardiol · September 1, 2022 IMPORTANCE: In patients with severe aortic stenosis and left ventricular ejection fraction (LVEF) less than 50%, early LVEF improvement after transcatheter aortic valve replacement (TAVR) is associated with improved 1-year mortality; however, its associati ... Full text Link to item Cite

Asymptomatic SARS-CoV-2 Infection Is Common Among ART-Treated People With HIV.

Journal article J Acquir Immune Defic Syndr · August 1, 2022 BACKGROUND: Limited data are available regarding asymptomatic COVID-19 among people with HIV (PWH). Data on a representative subset of PWH enrolled in Randomized Trial to Prevent Vascular Events in HIV, a global clinical trial, are presented here. METHODS: ... Full text Link to item Cite

Coronary Atherosclerosis, Cardiac Troponin, and Interleukin-6 in Patients With Chest Pain: The PROMISE Trial Results.

Journal article JACC Cardiovasc Imaging · August 2022 BACKGROUND: Increased inflammation and myocardial injury can be observed in the absence of myocardial infarction or obstructive coronary artery disease (CAD). OBJECTIVES: The authors determined whether biomarkers of inflammation and myocardial injury-inter ... Full text Link to item Cite

The PROMISE Minimal Risk Score Improves Risk Classification of Symptomatic Patients With Suspected CAD.

Journal article JACC Cardiovasc Imaging · August 2022 BACKGROUND: Guidelines for evaluating patients with suspected coronary artery disease (CAD) recommend pretest probability (PTP) estimation but provide no clear recommendations regarding diagnostic testing in patients with >5% to 15% risk of obstructive CAD ... Full text Link to item Cite

Left Ventricular Remodeling After Anterior-STEMI PCI: Imaging Observations in the Door-to-Unload (DTU) Pilot Trial.

Journal article J Invasive Cardiol · August 2022 OBJECTIVES: To determine the predictive value of cardiac magnetic resonance (CMR) and echocardiographic parameters on left ventricular (LV) remodeling in ST-segment elevation myocardial infarction (STEMI) patients without cardiogenic shock and treated with ... Full text Link to item Cite

Nativity-Related Disparities in Preterm Birth and Cardiovascular Risk in a Multiracial U.S. Cohort.

Journal article Am J Prev Med · June 2022 INTRODUCTION: Having a preterm birth is associated with future cardiovascular risk. Non-Hispanic Black women have higher rates of preterm birth than non-Hispanic White and Hispanic women, but nativity-related disparities in preterm birth are not well under ... Full text Link to item Cite

Physician judgement in predicting obstructive coronary artery disease and adverse events in chest pain patients.

Journal article Heart · May 12, 2022 OBJECTIVE: To evaluate informal physician judgement versus pretest probability scores in estimating risk in patients with suspected coronary artery disease (CAD). METHODS: We included 4533 patients from the PROMISE (Prospective Multicenter Imaging Study fo ... Full text Link to item Cite

Predicting When Women Will Achieve Equitable Representation in Four Specialties: The WHEN Study.

Journal article Am J Med · May 2022 BACKGROUND: For 2 decades, women have made up nearly half of medical school graduates, yet this has not translated to equity in promotion. We compare historical trends in the academic career pipeline among 4 specialties by sex. METHODS: Using the Associati ... Full text Link to item Cite

Presenting Symptoms in Patients Undergoing Coronary Artery Disease Evaluation: Association With Noninvasive Test Results and Clinical Outcomes in the PROMISE Trial.

Journal article Circ Cardiovasc Qual Outcomes · May 2022 BACKGROUND: Patients evaluated for coronary artery disease have a range of symptoms and underlying risk. The relationships between patient-described symptoms, clinician conclusions, and subsequent clinical management and outcomes remain incompletely descri ... Full text Link to item Cite

Sex-Related Factors in Valvular Heart Disease: JACC Focus Seminar 5/7.

Journal article J Am Coll Cardiol · April 19, 2022 Numerous sex-based differences are observed across the spectrum of valvular heart disease, starting with pathophysiology and progression of disease, moving on to compensation and comorbidities (both cardiovascular such as coronary artery disease and noncar ... Full text Link to item Cite

Women in procedural leadership roles in cardiology: The Women In Local Leadership (WILL) observational study.

Journal article Heart Rhythm · April 2022 BACKGROUND: Although 50% of U.S. medical students are women, this percentage fails to translate to cardiology. Gender disparities are striking in interventional cardiology (IC) and electrophysiology (EP) and in leadership. Left atrial appendage closure wit ... Full text Link to item Cite

Childbearing Among Women Cardiologists: The Interface of Experience, Impact, and the Law.

Journal article J Am Coll Cardiol · March 22, 2022 BACKGROUND: Maternity leave is highly variable in the United States given the lack of a federal workforce mandate. OBJECTIVES: The purpose of this study was to describe the experiences and impact of childbearing on women cardiologists and their careers, wi ... Full text Link to item Cite

Patient, physician and geographic predictors of cardiac stress testing strategy in Ontario, Canada: a population-based study.

Journal article BMJ Open · March 10, 2022 OBJECTIVES: To identify patient, physician and geographic level factors that are associated with variation in initial stress testing strategy in patients evaluated for chest pain. DESIGN: Retrospective cohort study. SETTING: Population-based study of patie ... Full text Link to item Cite

Differences in Cardiovascular Risk, Coronary Artery Disease, and Cardiac Events Between Black and White Individuals Enrolled in the PROMISE Trial.

Journal article JAMA Cardiol · March 1, 2022 IMPORTANCE: Race and ethnicity have been studied as risk factors in cardiovascular disease. How risk factors, epicardial coronary artery disease, and cardiac events differ between Black and White individuals undergoing noninvasive testing for coronary arte ... Full text Link to item Cite

The prospective randomized trial of the optimal evaluation of cardiac symptoms and revascularization: Rationale and design of the PRECISE trial.

Journal article Am Heart J · March 2022 BACKGROUND: Clinicians vary widely in their preferred diagnostic approach to patients with non-acute chest pain. Such variation exposes patients to potentially avoidable risks, as well as inefficient care with increased costs and unresolved patient concern ... Full text Link to item Cite

The Association of Preterm Birth With Maternal Nativity and Length of Residence Among Non-Hispanic Black Women.

Journal article CJC Open · March 2022 BACKGROUND: Preterm birth (PTB) is associated with future cardiovascular disease (CVD) risk and disproportionally affects non-Hispanic Black (NHB) women. Limited data exist on the influence of length of US residence on nativity-related disparities in PTB. ... Full text Link to item Cite

Prevalence and Correlates of Electrocardiographic Abnormalities in Adults With HIV: Insights From the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE).

Journal article J Acquir Immune Defic Syndr · March 1, 2022 BACKGROUND: People with HIV (PWH) are at increased risk of cardiovasvular disease (CVD) and sudden cardiac death. Previous work has suggested an association between HIV infection and electrocardiographic (ECG) abnormalities. There are limited data on the b ... Full text Link to item Cite

COVID-19 Vaccination Rates in a Global HIV Cohort.

Journal article J Infect Dis · February 15, 2022 Little is known regarding coronavirus disease 2019 (COVID-19) vaccination rates in people with HIV (PWH), a vulnerable population with significant morbidity from COVID-19. We assessed COVID-19 vaccination rates among 6952 PWH in the Randomized Trial to Pre ... Full text Link to item Cite

Prognostic value of coronary computed tomography angiographic derived fractional flow reserve: a systematic review and meta-analysis.

Journal article Heart · February 2022 OBJECTIVES: To obtain more powerful assessment of the prognostic value of fractional flow reserveCT testing we performed a systematic literature review and collaborative meta-analysis of studies that assessed clinical outcomes of CT-derived calculation of ... Full text Link to item Cite

Paravalvular regurgitation after transcatheter aortic valve replacement in intermediate-risk patients: a pooled PARTNER 2 study.

Journal article EuroIntervention · January 28, 2022 BACKGROUND: Moderate or worse paravalvular regurgitation (PVR) post transcatheter aortic valve replacement (TAVR) is associated with increased mortality. The mechanisms by which this occurs are not fully understood. AIMS: The aim of this study was to deter ... Full text Link to item Cite

Trans-lesional fractional flow reserve gradient as derived from coronary CT improves patient management: ADVANCE registry.

Journal article J Cardiovasc Comput Tomogr · 2022 BACKGROUND: The role of change in fractional flow reserve derived from CT (FFRCT) across coronary stenoses (ΔFFRCT) in guiding downstream testing in patients with stable coronary artery disease (CAD) is unknown. OBJECTIVES: To investigate the incremental v ... Full text Link to item Cite

The evolving role of coronary computed tomography in understanding sex differences in coronary atherosclerosis.

Journal article J Cardiovasc Comput Tomogr · 2022 Our understanding of sex differences in subclinical atherosclerosis and plaque composition and characteristics have greatly improved with the use of coronary computed tomography (CCTA) over the past years. CCTA has emerged as an important frontline diagnos ... Full text Link to item Cite

Are risk factors necessary for pretest probability assessment of coronary artery disease? A patient similarity network analysis of the PROMISE trial.

Journal article J Cardiovasc Comput Tomogr · 2022 BACKGROUND: Pretest probability (PTP) calculators utilize epidemiological-level findings to provide patient-level risk assessment of obstructive coronary artery disease (CAD). However, their limited accuracies question whether dissimilarities in risk facto ... Full text Link to item Cite

Significance of indeterminate and abnormal stress electrocardiography despite normal imaging in patients with suspected coronary artery disease - An analysis of the PROMISE trial.

Journal article J Electrocardiol · 2022 BACKGROUND: Abnormal and indeterminate electrocardiographic (ECG) changes during cardiac stress imaging are not uncommon. While the prognostic importance of abnormal ECG despite normal imaging has been previously studied, prognosis of indeterminate stress ... Full text Link to item Cite

Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study.

Journal article J Cardiovasc Comput Tomogr · 2022 BACKGROUND: Coronary artery calcium (CAC) and left ventricular diastolic dysfunction (LVDD) are strong predictors of cardiovascular events and share common risk factors. However, their independent association remains unclear. METHODS: In the Project Baseli ... Full text Link to item Cite

Cardiovascular Risk and Health Among People With Human Immunodeficiency Virus (HIV) Eligible for Primary Prevention: Insights From the REPRIEVE Trial.

Journal article Clin Infect Dis · December 6, 2021 BACKGROUND: In addition to traditional cardiovascular (CV) risk factors, antiretroviral therapy, lifestyle, and human immunodeficiency virus (HIV)-related factors may contribute to future CV events in persons with HIV (PWH). METHODS: Among participants in ... Full text Link to item Cite

Cardiovascular risk and outcomes in symptomatic patients with suspected coronary artery disease and non coronary vascular disease: A report from the PROMISE trial.

Journal article Am Heart J · December 2021 BACKGROUND: Non-coronary vascular disease (NCVD) is associated with adverse cardiovascular events. Little is known about physician risk assessment, prevalence of coronary artery disease (CAD), cardiac catheterization, and the performance of the atheroscler ... Full text Link to item Cite

Effects and tolerability of exercise therapy modality on cardiorespiratory fitness in lung cancer: a randomized controlled trial.

Journal article J Cachexia Sarcopenia Muscle · December 2021 BACKGROUND: Poor cardiorespiratory fitness (CRF) is a cardinal feature of post-treatment primary lung cancer. The most effective exercise therapy regimen to improve CRF has not been determined. METHODS: In this parallel-group factorial randomized controlle ... Full text Link to item Cite

Assessment of Obesity and Cardiometabolic Status by Integrase Inhibitor Use in REPRIEVE: A Propensity-Weighted Analysis of a Multinational Primary Cardiovascular Prevention Cohort of People With Human Immunodeficiency Virus.

Journal article Open Forum Infect Dis · December 2021 BACKGROUND: Emerging data demonstrate that the use of integrase inhibitor (INSTI)-based antiretroviral treatment (ART) is associated with increased weight, but the cardiometabolic health consequences of increased weight remains poorly understood. METHODS: ... Full text Link to item Cite

Nativity-Related Disparities in Preeclampsia and Cardiovascular Disease Risk Among a Racially Diverse Cohort of US Women.

Journal article JAMA Netw Open · December 1, 2021 IMPORTANCE: Preeclampsia is an independent risk factor for future cardiovascular disease and disproportionally affects non-Hispanic Black women. The association of maternal nativity and duration of US residence with preeclampsia and other cardiovascular ri ... Full text Link to item Cite

Chest Pain Redux: Updated and Patient Centered.

Journal article Circulation · November 30, 2021 Full text Link to item Cite

Risk Stratification With the Use of Coronary Computed Tomographic Angiography in Patients With Nonobstructive Coronary Artery Disease.

Journal article JACC Cardiovasc Imaging · November 2021 OBJECTIVES: The purpose of this study was to develop a risk prediction model for patients with nonobstructive CAD. BACKGROUND: Among stable chest pain patients, most cardiovascular (CV) events occur in those with nonobstructive coronary artery disease (CAD ... Full text Link to item Cite

Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial.

Journal article Eur Heart J · October 1, 2021 AIMS: Fractional flow reserve (FFRCT) using computed tomography coronary angiography (CTCA) determines both the presence of coronary artery disease and vessel-specific ischaemia. We tested whether an evaluation strategy based on FFRCT would improve economi ... Full text Link to item Cite

Estimating the real-world performance of the PROMISE minimal-risk tool.

Journal article Am Heart J · September 2021 BACKGROUND: Stable chest pain is a common indication for cardiac catheterization. We assessed the prognostic value of the Prospective Multicenter Imaging Study for Evaluation (PROMISE) Minimal-Risk Tool in identifying patients who are at very low risk of o ... Full text Link to item Cite

Gender Gaps in Salary and Representation in Academic Internal Medicine Specialties in the US.

Journal article JAMA Intern Med · September 1, 2021 This cross-sectional analysis examines survey data on academic physician salaries from 2018 to 2019 using the Association of American Medical Colleges Faculty Salary Report to evaluate demographics and salaries of academic internal medicine physician speci ... Full text Link to item Cite

Small whole heart volume predicts cardiovascular events in patients with stable chest pain: insights from the PROMISE trial.

Journal article Eur Radiol · August 2021 OBJECTIVES: The size of the heart may predict major cardiovascular events (MACE) in patients with stable chest pain. We aimed to evaluate the prognostic value of 3D whole heart volume (WHV) derived from non-contrast cardiac computed tomography (CT). METHOD ... Full text Link to item Cite

Temporal Trends and Clinical Trial Characteristics Associated With the Inclusion of Women in Heart Failure Trial Steering Committees: A Systematic Review.

Journal article Circ Heart Fail · August 2021 BACKGROUND: Trial steering committees (TSCs) steer the conduct of randomized controlled trials (RCTs). We examined the gender composition of TSCs in impactful heart failure RCTs and explored whether trial leadership by a woman was independently associated ... Full text Link to item Cite

Doppler Velocity Index Outcomes Following Surgical or Transcatheter Aortic Valve Replacement in the PARTNER Trials.

Journal article JACC Cardiovasc Interv · July 26, 2021 OBJECTIVES: The aim of this study was to assess the association between Doppler velocity index (DVI) and 2-year outcomes for balloon-expandable SAPIEN 3 transcatheter aortic valve replacement (TAVR) and for surgical aortic valve replacement (SAVR). BACKGRO ... Full text Link to item Cite

Prosthesis-Patient Mismatch After Aortic Valve Replacement in the PARTNER 2 Trial and Registry.

Journal article JACC Cardiovasc Interv · July 12, 2021 OBJECTIVES: This study aimed to compare incidence and impact of measured prosthesis-patient mismatch (PPMM) versus predicted PPM (PPMP) after surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). BACKGROUND: TAVR studi ... Full text Link to item Cite

Association of Hepatic Steatosis With Major Adverse Cardiovascular Events, Independent of Coronary Artery Disease.

Journal article Clin Gastroenterol Hepatol · July 2021 BACKGROUND & AIMS: Hepatic steatosis has been associated with increased risk of major adverse cardiovascular events (MACE) but it is not clear whether steatosis is independently associated with risk of MACE. We investigated whether steatosis is associated ... Full text Link to item Cite

Assessment of Coronary Artery Disease With Computed Tomography Angiography and Inflammatory and Immune Activation Biomarkers Among Adults With HIV Eligible for Primary Cardiovascular Prevention.

Journal article JAMA Netw Open · June 1, 2021 IMPORTANCE: Cardiovascular disease (CVD) is increased among people with HIV (PWH), but little is known regarding the prevalence and extent of coronary artery disease (CAD) and associated biological factors in PWH with low to moderate traditional CVD risk. ... Full text Link to item Cite

Global Prevalence and Impact of Hostility, Discrimination, and Harassment in the Cardiology Workplace.

Journal article J Am Coll Cardiol · May 18, 2021 BACKGROUND: Discrimination and emotional and sexual harassment create a hostile work environment (HWE). The global prevalence of HWE in cardiology is unknown, as is its impact. OBJECTIVES: This study sought to evaluate emotional harassment, discrimination, ... Full text Link to item Cite

Prospective Evaluation of TMVR for Failed Surgical Annuloplasty Rings: MITRAL Trial Valve-in-Ring Arm 1-Year Outcomes.

Journal article JACC Cardiovasc Interv · April 26, 2021 OBJECTIVES: The authors report 1-year outcomes of high-risk patients with failed surgical annuloplasty rings undergoing transseptal mitral valve-in-ring (MViR) with the SAPIEN 3 aortic transcatheter heart valve (THV). BACKGROUND: The MITRAL (Mitral Implant ... Full text Link to item Cite

Prospective Study of TMVR Using Balloon-Expandable Aortic Transcatheter Valves in MAC: MITRAL Trial 1-Year Outcomes.

Journal article JACC Cardiovasc Interv · April 26, 2021 OBJECTIVES: The aim of this study was to evaluate 1-year outcomes of valve-in-mitral annular calcification (ViMAC) in the MITRAL (Mitral Implantation of Transcatheter Valves) trial. BACKGROUND: The MITRAL trial is the first prospective study evaluating the ... Full text Link to item Cite

Infective Endocarditis in Patients on Chronic Hemodialysis.

Journal article J Am Coll Cardiol · April 6, 2021 BACKGROUND: Infective endocarditis (IE) is a common and serious complication in patients receiving chronic hemodialysis (HD). OBJECTIVES: This study sought to investigate whether there are significant differences in complications, cardiac surgery, relapses ... Full text Link to item Cite

Sex-Specific Differences in Heart Failure: Pathophysiology, Risk Factors, Management, and Outcomes.

Journal article Can J Cardiol · April 2021 Heart failure (HF) is a leading cause of hospitalisation, morbidity, and mortality in Canada. There are sex-specific differences in the etiology, epidemiology, comorbidities, treatment response, and treatment adverse effects that have implications on outco ... Full text Link to item Cite

Association of Metabolic Phenotypes With Coronary Artery Disease and Cardiovascular Events in Patients With Stable Chest Pain.

Journal article Diabetes Care · April 2021 OBJECTIVE: Obesity and metabolic syndrome are associated with major adverse cardiovascular events (MACE). However, whether distinct metabolic phenotypes differ in risk for coronary artery disease (CAD) and MACE is unknown. We sought to determine the associ ... Full text Link to item Cite

Deep convolutional neural networks to predict cardiovascular risk from computed tomography.

Journal article Nat Commun · January 29, 2021 Coronary artery calcium is an accurate predictor of cardiovascular events. While it is visible on all computed tomography (CT) scans of the chest, this information is not routinely quantified as it requires expertise, time, and specialized equipment. Here, ... Full text Link to item Cite

Disparities in Cardiovascular Research Output and Disease Outcomes among High-, Middle- and Low-Income Countries - An Analysis of Global Cardiovascular Publications over the Last Decade (2008-2017).

Journal article Glob Heart · January 18, 2021 BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. Health research is crucial to managing disease burden. Previous work has highlighted marked discrepancies in research output and disease burden between high-in ... Full text Link to item Cite

Evaluation of Women and Underrepresented Racial and Ethnic Group Representation in a General Cardiology Fellowship After a Systematic Recruitment Initiative.

Journal article JAMA Netw Open · January 4, 2021 IMPORTANCE: The proportion of women and underrepresented racial and ethnic groups (UREGs) matriculating into general cardiology fellowships remains low. OBJECTIVE: To assess a systematic recruitment initiative aimed at ensuring adequate matriculation of wo ... Full text Link to item Cite

Multimodality cardiac imaging in the 21st century: evolution, advances and future opportunities for innovation.

Journal article Br J Radiol · January 1, 2021 Cardiovascular imaging has significantly evolved since the turn of the century. Progress in the last two decades has been marked by advances in every modality used to image the heart, including echocardiography, cardiac magnetic resonance, cardiac CT and n ... Full text Link to item Cite

Task-dependent estimability index to assess the quality of cardiac computed tomography angiography for quantifying coronary stenosis.

Journal article J Med Imaging (Bellingham) · January 2021 Purpose: Quantifying stenosis in cardiac computed tomography angiography (CTA) images remains a difficult task, as image noise and cardiac motion can degrade image quality and distort underlying anatomic information. The purpose of this study was to develo ... Full text Link to item Cite

Aerobic Versus Resistance Training Effects on Ventricular-Arterial Coupling and Vascular Function in the STRRIDE-AT/RT Trial.

Journal article Front Cardiovasc Med · 2021 Background: The goal was studying the differential effects of aerobic training (AT) vs. resistance training (RT) on cardiac and peripheral arterial capacity on cardiopulmonary (CP) and peripheral vascular (PV) function in sedentary and obese adults. Method ... Full text Link to item Cite

Diastolic Function and Clinical Outcomes After Transcatheter Aortic Valve Replacement: PARTNER 2 SAPIEN 3 Registry.

Journal article J Am Coll Cardiol · December 22, 2020 BACKGROUND: Few studies have evaluated if diastolic function could predict outcomes in patients with aortic stenosis. OBJECTIVES: The authors aimed to assess the association between diastolic dysfunction (DD) and outcomes in patients with aortic stenosis u ... Full text Link to item Cite

Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial.

Journal article Cancer Prev Res (Phila) · December 2020 Observational studies report that physical activity and metformin are associated with improved clinical outcome in patients with cancer. Inflammation is one biological mechanism hypothesized to mediate these associations. In this phase II, multicenter, 2 × ... Full text Link to item Cite

Sex Differences in Coronary Computed Tomography Angiography-Derived Fractional Flow Reserve: Lessons From ADVANCE.

Journal article JACC Cardiovasc Imaging · December 2020 OBJECTIVES: This study is to determine the management and clinical outcomes of patients investigated with coronary computed tomography angiography (CCTA)-derived fractional flow reserve (FFRCT) according to sex. BACKGROUND: Women are underdiagnosed with co ... Full text Link to item Cite

Cost-effectiveness Analysis of Anatomic vs Functional Index Testing in Patients With Low-Risk Stable Chest Pain.

Journal article JAMA Netw Open · December 1, 2020 IMPORTANCE: Both noninvasive anatomic and functional testing strategies are now routinely used as initial workup in patients with low-risk stable chest pain (SCP). OBJECTIVE: To determine whether anatomic approaches (ie, coronary computed tomography angiog ... Full text Link to item Cite

Incorporating Coronary Calcification Into Pre-Test Assessment of the Likelihood of Coronary Artery Disease.

Journal article J Am Coll Cardiol · November 24, 2020 BACKGROUND: The prevalence of obstructive coronary artery disease (CAD) in symptomatic patients referred for diagnostic testing has declined, warranting optimization of individualized diagnostic strategies. OBJECTIVES: This study sought to present a simple ... Full text Link to item Cite

Use of Cardiac Noninvasive Testing After Emergency Department Discharge: Association of Hospital Network Testing Intensity and Outcomes in Ontario, Canada.

Journal article J Am Heart Assoc · November 3, 2020 Background The relationship between noninvasive cardiac diagnostic testing intensity and downstream clinical outcomes is unclear. Our objective was to examine the relationship between hospital network noninvasive cardiac diagnostic testing intensity and do ... Full text Link to item Cite

Characteristics of Heart Failure Trials Associated With Under-Representation of Women as Lead Authors.

Journal article J Am Coll Cardiol · October 27, 2020 BACKGROUND: Clinical trials change practice in cardiology, and leading them requires research training, mentorship, sponsorship, and networking. Women report challenges in obtaining these opportunities. OBJECTIVES: The purpose of this review was to evaluat ... Full text Link to item Cite

Structural Deterioration of Transcatheter Versus Surgical Aortic Valve Bioprostheses in the PARTNER-2 Trial.

Journal article J Am Coll Cardiol · October 20, 2020 BACKGROUND: It is unknown whether transcatheter valves will have similar durability as surgical bioprosthetic valves. Definitions of structural valve deterioration (SVD), based on valve related reintervention or death, underestimate the incidence of SVD. O ... Full text Link to item Cite

Improvement in left ventricular function following higher-risk percutaneous coronary intervention in patients with ischemic cardiomyopathy.

Journal article Catheter Cardiovasc Interv · October 1, 2020 BACKGROUND: Surgical revascularization is associated with improved ventricular function and clinical outcomes among patients with ischemic cardiomyopathy. There are less extensive data on changes in ventricular function among patients with ischemic cardiom ... Full text Link to item Cite

Guideline-Based Statin Eligibility, Coronary Artery Stenosis and Cardiovascular Events in Patients with Stable Chest Pain: A Secondary Analysis of the PROMISE Randomized Clinical Trial.

Journal article J Clin Med · September 24, 2020 BACKGROUND: Recommendations for preventive statin treatment in patients with stable chest pain may be difficult as symptoms can be unspecific. It is unclear if coronary CT angiography (CTA)-detected coronary artery disease (CAD) can optimize statin prescri ... Full text Link to item Cite

Increasing Diversity in Cardiology: It Will Take a Village.

Journal article J Am Coll Cardiol · September 8, 2020 Full text Link to item Cite

RESPONSE: The Time for Action Is Now.

Journal article J Am Coll Cardiol · August 25, 2020 Full text Link to item Cite

Myocardial Steatosis Among Antiretroviral Therapy-Treated People With Human Immunodeficiency Virus Participating in the REPRIEVE Trial.

Journal article J Infect Dis · July 9, 2020 BACKGROUND: People with human immunodeficiency virus (PWH) face increased risks for heart failure and adverse heart failure outcomes. Myocardial steatosis predisposes to diastolic dysfunction, a heart failure precursor. We aimed to characterize myocardial ... Full text Link to item Cite

Correlates and Timing of Reproductive Aging Transitions in a Global Cohort of Midlife Women With Human Immunodeficiency Virus: Insights From the REPRIEVE Trial.

Journal article J Infect Dis · July 9, 2020 BACKGROUND: Reproductive aging may contribute to cardiometabolic comorbid conditions. We integrated data on gynecologic history with levels of an ovarian reserve marker (anti-müllerian hormone [AMH)] to interrogate reproductive aging patterns and associate ... Full text Link to item Cite

Characteristics of REPRIEVE Trial Participants Identifying Across the Transgender Spectrum.

Journal article J Infect Dis · July 9, 2020 Because persons who identify across the transgender spectrum (PATS) are a key population in human immunodeficiency virus (HIV) yet are underreported in HIV and cardiovascular research, we aimed to characterize this population within the REPRIEVE global cli ... Full text Link to item Cite

Leveraging a Landmark Trial of Primary Cardiovascular Disease Prevention in Human Immunodeficiency Virus: Introduction From the REPRIEVE Coprincipal Investigators.

Journal article J Infect Dis · July 9, 2020 The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) is the largest study of cardiovascular disease in human immunodeficiency virus. Enrolling 7770 participants from 2015 to 2019 with sites across 5 continents, REPRIEVE will assess the effects ... Full text Link to item Cite

Patterns of Antiretroviral Therapy Use and Immunologic Profiles at Enrollment in the REPRIEVE Trial.

Journal article J Infect Dis · July 9, 2020 BACKGROUND: Patterns of antiretroviral therapy (ART) use and immunologic correlates vary globally, and contemporary trends are not well described. METHODS: The REPRIEVE trial (Randomized Trial to Prevent Vascular Events in HIV) enrolled persons with human ... Full text Link to item Cite

Physical Function Impairment and Frailty in Middle-Aged People Living With Human Immunodeficiency Virus in the REPRIEVE Trial Ancillary Study PREPARE.

Journal article J Infect Dis · July 9, 2020 BACKGROUND: People with human immunodeficiency virus (PWH) are at risk for accelerated development of physical function impairment and frailty; both associated with increased risk of falls, hospitalizations, and death. Identifying factors associated with p ... Full text Link to item Cite

An Evaluation of Baseline Kidney Function in the REPRIEVE Trial of Pitavastatin in Human Immunodeficiency Virus.

Journal article J Infect Dis · July 9, 2020 BACKGROUND: Chronic kidney disease is a common comorbid condition among persons living with human immunodeficiency virus (PWH). We characterized baseline kidney function in the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) trial cohort. MET ... Full text Link to item Cite

Clinical Effectiveness of Cardiac Noninvasive Diagnostic Testing in Outpatients Evaluated for Stable Coronary Artery Disease.

Journal article J Am Heart Assoc · July 7, 2020 Background Despite more than 4 million cardiac noninvasive diagnostic tests (NIT) being performed annually for stable coronary artery disease in the United States, it is unclear whether they are associated with downstream improvements in outcomes when comp ... Full text Link to item Cite

Prognostic Value of Coronary CTA in Stable Chest Pain: CAD-RADS, CAC, and Cardiovascular Events in PROMISE.

Journal article JACC Cardiovasc Imaging · July 2020 OBJECTIVES: The purpose of this study was to compare Coronary Artery Disease Reporting and Data System (CAD-RADS) to traditional stenosis categories and the coronary artery calcium score (CACS) for predicting cardiovascular events in patients with stable c ... Full text Link to item Cite

Fractional Flow Reserve Derived from Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain: Rationale and Design of the FORECAST Trial.

Journal article Cardiovasc Revasc Med · July 2020 BACKGROUND: Fractional flow reserve measurement based on computed tomography (FFRCT) is a novel, well validated, non-invasive method for determining the presence and extent of coronary artery disease (CAD) combined with a physiological assessment of vessel ... Full text Link to item Cite

Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis.

Journal article J Clin Invest · July 1, 2020 BACKGROUNDNovel therapeutic approaches are critically needed for Staphylococcus aureus bloodstream infections (BSIs), particularly for methicillin-resistant S. aureus (MRSA). Exebacase, a first-in-class antistaphylococcal lysin, is a direct lytic agent tha ... Full text Link to item Cite

Outcome of Flow-Gradient Patterns of Aortic Stenosis After Aortic Valve Replacement: An Analysis of the PARTNER 2 Trial and Registry.

Journal article Circ Cardiovasc Interv · July 2020 BACKGROUND: Although aortic valve replacement is associated with a major benefit in high-gradient (HG) severe aortic stenosis (AS), the results in low-gradient (LG, mean gradient <40 mm Hg) AS are conflicting. LG severe AS may be subdivided in classical lo ... Full text Link to item Cite

Left Ventricular Hypertrophy and Clinical Outcomes Over 5 Years After TAVR: An Analysis of the PARTNER Trials and Registries.

Journal article JACC Cardiovasc Interv · June 8, 2020 OBJECTIVES: This study sought to evaluate the association between severity of left ventricular hypertrophy (LVH) before transcatheter aortic valve replacement (TAVR) and outcomes out to 5 years. BACKGROUND: Prior studies assessing the association between b ... Full text Link to item Cite

Enrollment of Older Patients, Women, and Racial/Ethnic Minority Groups in Contemporary Acute Coronary Syndrome Clinical Trials: A Systematic Review.

Journal article JAMA Cardiol · June 1, 2020 IMPORTANCE: Although age, sex, and race/ethnicity are important factors when generalizing the findings of clinical trials to routine practice, trends in the representation of these groups in contemporary acute coronary syndrome (ACS) trials are not well de ... Full text Link to item Cite

Regression of Left Ventricular Mass After Transcatheter Aortic Valve Replacement: The PARTNER Trials and Registries.

Journal article J Am Coll Cardiol · May 19, 2020 BACKGROUND: Greater early left ventricular mass index (LVMi) regression is associated with fewer hospitalizations 1 year after transcatheter aortic valve replacement (TAVR). The association between LVMi regression and longer-term post-TAVR outcomes is uncl ... Full text Link to item Cite

Cardiac remodeling after large ST-elevation myocardial infarction in the current therapeutic era.

Journal article Am Heart J · May 2020 BACKGROUND: The evolution and clinical impact of cardiac remodeling after large ST-elevation myocardial infarction (STEMI) is not well delineated in the current therapeutic era. METHODS: The PRESERVATION I trial longitudinally assessed cardiac structure an ... Full text Link to item Cite

Risk Analysis and Outcomes of Postoperative Renal Failure After Aortic Valve Surgery in the United States.

Journal article Ann Thorac Surg · April 2020 BACKGROUND: Postoperative renal failure (RF) compromises early outcomes in cardiac surgery. In contrast, long-term survival and progression of RF after aortic valve replacement (AVR) with or without coronary artery bypass graft surgery (CABG) remain undefi ... Full text Link to item Cite

Implications of Abnormal Exercise Electrocardiography With Normal Stress Echocardiography.

Journal article JAMA Intern Med · April 1, 2020 IMPORTANCE: Patients with abnormal (positive) exercise electrocardiography, but normal stress echocardiography (+ECG/-Echo) are commonly encountered in clinical practice; however, the prognostic significance of this discordant result is unclear. OBJECTIVE: ... Full text Link to item Cite

Sex Differences in Quality of Life and Clinical Outcomes in Patients With Advanced Heart Failure: Insights From the PAL-HF Trial.

Journal article Circ Heart Fail · April 2020 BACKGROUND: Palliative care improves quality of life in patients with heart failure. Whether men and women with heart failure derive similar benefit from palliative care interventions remains unknown. METHODS: In a secondary analysis of the PAL-HF trial (P ... Full text Link to item Cite

Clinical and Economic Implications of Inconclusive Noninvasive Test Results in Stable Patients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.

Journal article Circ Cardiovasc Imaging · April 2020 BACKGROUND: Inconclusive noninvasive tests complicate the care of patients with suspected coronary artery disease, but their prevalence and impact on management, outcomes, and costs are not well described. METHODS: PROMISE (Prospective Multicenter Imaging ... Full text Link to item Cite

Inter- and intrasite variability of mortality and stroke for sites performing both surgical and transcatheter aortic valve replacement for aortic valve stenosis in intermediate-risk patients.

Journal article J Thorac Cardiovasc Surg · April 2020 OBJECTIVES: Multisite procedure-based randomized trials may be confounded by performance variability and variability among sites. Therefore, we studied variability in mortality and stroke after patients were randomized to surgical (SAVR) or transcatheter a ... Full text Link to item Cite

Postoperative atrial fibrillation: Sex-specific characteristics and effect on survival.

Journal article J Thorac Cardiovasc Surg · April 2020 BACKGROUND: We sought to fill important gaps in the existing evidence regarding new-onset atrial fibrillation (AF) after coronary artery bypass graft surgery (CABG) by comparing the incidence, characteristics, and effect on long-term survival between men a ... Full text Link to item Cite

Outcomes of Transcatheter Aortic Valve Replacement in Patients With Bicuspid Aortic Valve Disease: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal article Circulation · March 31, 2020 BACKGROUND: Patients with bicuspid aortic valve (AV) stenosis were excluded from the pivotal evaluations of transcatheter AV replacement (TAVR) devices. We sought to evaluate the outcomes of TAVR in patients with bicuspid AV stenosis in comparison with tho ... Full text Link to item Cite

Thirty-Day Outcomes of Transcatheter Mitral Valve Replacement for Degenerated Mitral Bioprostheses (Valve-in-Valve), Failed Surgical Rings (Valve-in-Ring), and Native Valve With Severe Mitral Annular Calcification (Valve-in-Mitral Annular Calcification) in the United States: Data From the Society of Thoracic Surgeons/American College of Cardiology/Transcatheter Valve Therapy Registry.

Journal article Circ Cardiovasc Interv · March 2020 BACKGROUND: Transcatheter mitral valve replacement using aortic transcatheter heart valves has recently become an alternative for patients with degenerated mitral bioprostheses, failed surgical repairs with annuloplasty rings or severe mitral annular calci ... Full text Link to item Cite

Invited Commentary.

Journal article Ann Thorac Surg · March 2020 Full text Link to item Cite

Five-Year Outcomes of Transcatheter or Surgical Aortic-Valve Replacement.

Journal article N Engl J Med · February 27, 2020 BACKGROUND: There are scant data on long-term clinical outcomes and bioprosthetic-valve function after transcatheter aortic-valve replacement (TAVR) as compared with surgical aortic-valve replacement in patients with severe aortic stenosis and intermediate ... Full text Link to item Cite

Impact of renin-angiotensin system inhibitors on clinical outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement: an analysis of from the PARTNER 2 trial and registries.

Journal article Eur Heart J · February 21, 2020 AIMS: Left ventricular pressure overload is associated with activation of the cardiac renin-angiotensin system, which may contribute to myocardial fibrosis and worse clinical outcomes. We sought to assess the association between treatment with angiotensin- ... Full text Link to item Cite

Effects of Exercise Therapy Dosing Schedule on Impaired Cardiorespiratory Fitness in Patients With Primary Breast Cancer: A Randomized Controlled Trial.

Journal article Circulation · February 18, 2020 BACKGROUND: Current exercise guidelines for clinical populations recommend an exercise therapy (ET) prescription of fixed intensity (moderate), duration (40-50 minutes per session), and volume (120-160 min/wk). A critical overarching element of exercise pr ... Full text Link to item Cite

Impact of Aortic Atherosclerosis Burden on Outcomes of Surgical Aortic Valve Replacement.

Journal article Ann Thorac Surg · February 2020 BACKGROUND: Epiaortic ultrasound detects and localizes ascending aortic atherosclerosis. In this analysis we investigated the association between epiaortic ultrasound-based atheroma grade during surgical aortic valve replacement (SAVR) and perioperative ad ... Full text Link to item Cite

Discordances between predicted and actual risk in obese patients with suspected cardiac ischaemia.

Journal article Heart · February 2020 OBJECTIVES: To test the relationship between increasing severity of obesity, calculated risk and observed outcomes. METHODS: Patients with symptoms suggestive of coronary artery disease (CAD) (n=10 003) were stratified according to body mass index (BMI). W ... Full text Link to item Cite

Age-Related Differences in the Noninvasive Evaluation for Possible Coronary Artery Disease: Insights From the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) Trial.

Journal article JAMA Cardiol · February 1, 2020 IMPORTANCE: Although cardiovascular (CV) disease represents the leading cause of morbidity and mortality that increases with age, the best noninvasive test to identify older patients at risk for CV events remains unknown. OBJECTIVE: To determine whether th ... Full text Link to item Cite

Successful recruitment of a multi-site international randomized placebo-controlled trial in people with HIV with attention to diversity of race and ethnicity: critical role of central coordination.

Journal article HIV Res Clin Pract · February 2020 Background: The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) is a multicenter, randomized, placebo-controlled trial, designed to test whether a statin medication can prevent cardiovascular disease in people with HIV. REPRIEVE recently comp ... Full text Link to item Cite

Randomized Phase II Trial of Exercise, Metformin, or Both on Metabolic Biomarkers in Colorectal and Breast Cancer Survivors.

Journal article JNCI Cancer Spectr · February 2020 BACKGROUND: Observational data support inverse relationships between exercise or metformin use and disease outcomes in colorectal and breast cancer survivors, although the mechanisms underlying these associations are not well understood. METHODS: In a phas ... Full text Link to item Cite

The Effect and Relationship of Frailty Indices on Survival After Transcatheter Aortic Valve Replacement.

Journal article JACC Cardiovasc Interv · January 27, 2020 OBJECTIVES: This study sought to evaluate the ability of individual markers of frailty to predict outcomes after transcatheter aortic valve replacement (TAVR) and of their discriminatory value in different age groups. BACKGROUND: Appropriate patient select ... Full text Link to item Cite

Mid-Term Outcomes of Transcatheter Aortic Valve Replacement in Extremely Large Annuli With Edwards SAPIEN 3 Valve.

Journal article JACC Cardiovasc Interv · January 27, 2020 OBJECTIVES: The aim of this study was to report the 1-year results of transcatheter aortic valve replacement (TAVR) with the Edwards SAPIEN 3 (S3) valve in extremely large annuli. BACKGROUND: Favorable 30-day outcomes of S3 TAVR in annuli >683 mm2 have pre ... Full text Link to item Cite

Assessment of Subspecialty Choices of Men and Women in Internal Medicine From 1991 to 2016.

Journal article JAMA Intern Med · January 1, 2020 This case series examines the percentage of women residencies and fellowships in 9 internal medicine medical subspecialties from 1991 to 2016. ... Full text Link to item Cite

Association of Pulmonary Hypertension With Clinical Outcomes of Transcatheter Mitral Valve Repair.

Journal article JAMA Cardiol · January 1, 2020 IMPORTANCE: Pulmonary hypertension (pHTN) is associated with increased risk of mortality after mitral valve surgery for mitral regurgitation. However, its association with clinical outcomes in patients undergoing transcatheter mitral valve repair (TMVr) wi ... Full text Link to item Cite

Incidence, Temporal Trends, and Associated Outcomes of Vascular and Bleeding Complications in Patients Undergoing Transfemoral Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry.

Journal article Circ Cardiovasc Interv · January 2020 BACKGROUND: Vascular and bleeding complications were commonly reported in transcatheter aortic valve replacement clinical trials. Little is known about complication rates in contemporary US clinical practice or clinical outcomes associated with these compl ... Full text Link to item Cite

The Project Baseline Health Study: a step towards a broader mission to map human health.

Journal article NPJ Digit Med · 2020 The Project Baseline Health Study (PBHS) was launched to map human health through a comprehensive understanding of both the health of an individual and how it relates to the broader population. The study will contribute to the creation of a biomedical info ... Full text Open Access Link to item Cite

Development and evaluation of 'Sleep, Baby & You'-An approach to supporting parental well-being and responsive infant caregiving.

Journal article PLoS One · 2020 Disrupted parental sleep, presenting as post-partum fatigue and perceived as problematic infant sleep, is related to increased symptoms of depression and anxiety among new mothers and fathers. Previous research indicates that UK parents would value an appr ... Full text Link to item Cite

Mitral regurgitation severity predicts one-year therapeutic benefit of Tendyne transcatheter mitral valve implantation.

Journal article EuroIntervention · December 20, 2019 AIMS: Longitudinal outcomes of transcatheter therapies for secondary mitral regurgitation (MR) have been variable. This study examined predictors of one-year outcome following transcatheter mitral valve implantation (TMVI) with the Tendyne device. METHODS ... Full text Link to item Cite

Prosthetic Valve Endocarditis After TAVR and SAVR: Insights From the PARTNER Trials.

Journal article Circulation · December 10, 2019 BACKGROUND: Prosthetic valve endocarditis (PVE) is a rare but critical mechanism of valve failure and death after transcatheter and surgical aortic valve replacement (TAVR, SAVR) warranting further analysis in modern aortic valve replacement experience. We ... Full text Link to item Cite

Health Status After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis.

Journal article J Am Coll Cardiol · December 10, 2019 BACKGROUND: In patients with severe aortic stenosis (AS) at low surgical risk, treatment with transcatheter aortic valve replacement (TAVR) results in lower rates of death, stroke, and rehospitalization at 1 year compared with surgical aortic valve replace ... Full text Link to item Cite

Clinical Effectiveness of Cardiac Noninvasive Diagnostic Testing in Patients Discharged From the Emergency Department for Chest Pain.

Journal article J Am Heart Assoc · November 5, 2019 Background More than 4 million cardiac noninvasive diagnostic tests are performed annually in the United States. However, questions remain regarding their effectiveness in improving clinical outcomes. We sought to evaluate whether noninvasive diagnostic te ... Full text Link to item Cite

Relevance of anatomical, plaque, and hemodynamic characteristics of non-obstructive coronary lesions in the prediction of risk for acute coronary syndrome.

Journal article Eur Radiol · November 2019 OBJECTIVES: We explored the anatomical, plaque, and hemodynamic characteristics of high-risk non-obstructive coronary lesions that caused acute coronary syndrome (ACS). METHODS: From the EMERALD study which included ACS patients with available coronary CT ... Full text Link to item Cite

Patient and Hospital Characteristics of Mitral Valve Surgery in the United States.

Journal article JAMA Cardiol · November 1, 2019 IMPORTANCE: Volume metrics may have relevance in the evaluation of valve center expertise. However, a paucity of data exists regarding the quantity, volume, and geographic location of mitral valve (MV) surgical centers in the United States and the proporti ... Full text Link to item Cite

Making cardiac surgery feasible in African countries: Experience from Namibia, Uganda, and Zambia.

Journal article J Thorac Cardiovasc Surg · November 2019 OBJECTIVES: Few African countries have the resources to provide optimal cardiac surgery care. We explored needs at cardiac surgery centers in Namibia, Zambia, and Uganda. Our objectives were (1) to determine the key variables to be included in a cardiac su ... Full text Link to item Cite

Current Demographic Status of Cardiologists in the United States.

Journal article JAMA Cardiol · October 1, 2019 IMPORTANCE: Increasing cardiology workforce diversity will expand the talent of the applicant pool and may reduce health care disparities. OBJECTIVE: To assess US cardiology physician workforce demographics by sex and race/ethnicity in the context of the U ... Full text Link to item Cite

Performance of Traditional Pretest Probability Estimates in Stable Patients Undergoing Myocardial Perfusion Imaging.

Journal article Circ Cardiovasc Imaging · October 2019 BACKGROUND: The yield of myocardial perfusion imaging is low in contemporary patients with suspected coronary artery disease (CAD) selected based on American College of Cardiology Foundation/American Heart Association pretest probability estimate. We compa ... Full text Link to item Cite

Pulmonary Venous Waveforms Predict Rehospitalization and Mortality After Percutaneous Mitral Valve Repair.

Journal article JACC Cardiovasc Imaging · October 2019 OBJECTIVES: In this study, the authors hypothesized that intraprocedural improvement of pulmonary venous (PV) waveforms are predictive of improved outcomes. In this report, they analyzed intraprocedural invasive and echocardiographic changes with respect t ... Full text Link to item Cite

Anticoagulation After Surgical or Transcatheter Bioprosthetic Aortic Valve Replacement.

Journal article J Am Coll Cardiol · September 3, 2019 BACKGROUND: There is paucity of evidence on the impact of anticoagulation (AC) after bioprosthetic aortic valve replacement (AVR) on valve hemodynamics and clinical outcomes. OBJECTIVES: The study aimed to assess the impact of AC after bioprosthetic AVR on ... Full text Link to item Cite

The Evolving Design of NIH-Funded Cardio-Oncology Studies to Address Cancer Treatment-Related Cardiovascular Toxicity.

Journal article JACC CardioOncol · September 2019 Cardiovascular (CV) toxicity from cancer therapy is a significant and growing concern. Conventional oncology clinical trial designs focused singularly on cancer treatment efficacy have not provided sufficient information on both CV risk factors and outcome ... Full text Link to item Cite

REPLY: Patch and unload.

Journal article J Thorac Cardiovasc Surg · September 2019 Full text Link to item Cite

Commentary: Left ventricular free wall rupture: Patch and unload?

Journal article J Thorac Cardiovasc Surg · September 2019 Full text Link to item Cite

Antithrombotic Therapy and Cardiovascular Outcomes After Transcatheter Aortic Valve Replacement in Patients With Atrial Fibrillation.

Journal article JACC Cardiovasc Interv · August 26, 2019 OBJECTIVES: The study sought to determine the patterns of antithrombotic therapy and association with clinical outcomes in patients with atrial fibrillation (AF) and CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, pr ... Full text Link to item Cite

Smoking and TAVR.

Journal article J Am Heart Assoc · August 20, 2019 See Article Qintar et al. ... Full text Link to item Cite

Effect of Baseline Left Ventricular Ejection Fraction on 2-Year Outcomes After Transcatheter Aortic Valve Replacement: Analysis of the PARTNER 2 Trials.

Journal article Circ Heart Fail · August 2019 BACKGROUND: Impaired left ventricular function is associated with worse prognosis among patients with aortic stenosis treated medically or with surgical aortic valve replacement. It is unclear whether reduced left ventricular ejection fraction (LVEF) is an ... Full text Link to item Cite

New-onset left bundle branch block after transcatheter aortic valve replacement is associated with adverse long-term clinical outcomes in intermediate-risk patients: an analysis from the PARTNER II trial.

Journal article Eur Heart J · July 14, 2019 AIMS: Transcatheter aortic valve replacement (TAVR) is now an established therapy for intermediate-risk surgical candidates with symptomatic, severe aortic stenosis. The clinical impact of new-onset left bundle branch block (LBBB) after TAVR remains contro ... Full text Link to item Cite

Controversies in Diagnostic Imaging of Patients With Suspected Stable and Acute Chest Pain Syndromes.

Journal article JACC Cardiovasc Imaging · July 2019 There has been a tremendous growth quantity of high-quality imaging evidence in the area of acute and stable ischemic heart disease (SIHD). A number of recent comparative effectiveness trials have spurned significant controversies in the field of cardiovas ... Full text Link to item Cite

Procedural Volume and Outcomes for Transcatheter Aortic-Valve Replacement.

Journal article N Engl J Med · June 27, 2019 BACKGROUND: During the introduction of transcatheter aortic-valve replacement (TAVR) in the United States, requirements regarding procedural volume were mandated by the Centers for Medicare and Medicaid Services as a condition of reimbursement. A better un ... Full text Link to item Cite

Association Between Transcatheter Aortic Valve Replacement and Early Postprocedural Stroke.

Journal article JAMA · June 18, 2019 IMPORTANCE: Reducing postprocedural stroke is important to improve the safety of transcatheter aortic valve replacement (TAVR). OBJECTIVE: This study evaluated the trends of stroke occurring within 30 days after the procedure during the first 5 years TAVR ... Full text Link to item Cite

Transcatheter Aortic Valve Replacement in Patients With End-Stage Renal Disease.

Journal article J Am Coll Cardiol · June 11, 2019 BACKGROUND: In patients with end-stage renal disease (ESRD), surgical aortic valve replacement is associated with higher early and late mortality, and adverse outcomes compared with patients without renal disease. Transcatheter aortic valve replacement (TA ... Full text Link to item Cite

Association Between Transcatheter Aortic Valve Replacement for Bicuspid vs Tricuspid Aortic Stenosis and Mortality or Stroke.

Journal article JAMA · June 11, 2019 IMPORTANCE: Transcatheter aortic valve replacement (TAVR) indications are expanding, leading to an increasing number of patients with bicuspid aortic stenosis undergoing TAVR. Pivotal randomized trials conducted to obtain US Food and Drug Administration ap ... Full text Link to item Cite

Identification of High-Risk Plaques Destined to Cause Acute Coronary Syndrome Using Coronary Computed Tomographic Angiography and Computational Fluid Dynamics.

Journal article JACC Cardiovasc Imaging · June 2019 OBJECTIVES: The authors investigated the utility of noninvasive hemodynamic assessment in the identification of high-risk plaques that caused subsequent acute coronary syndrome (ACS). BACKGROUND: ACS is a critical event that impacts the prognosis of patien ... Full text Link to item Cite

High-Sensitivity Troponin I and Coronary Computed Tomography in Symptomatic Outpatients With Suspected CAD: Insights From the PROMISE Trial.

Journal article JACC Cardiovasc Imaging · June 2019 OBJECTIVES: The goal of this study was to examine associations between concentrations of high-sensitivity troponin I (hsTnI) (measured by using a single-molecule counting method) and obstructive coronary artery disease (CAD) in 1,844 stable, symptomatic ou ... Full text Link to item Cite

Rationale and design of the Mechanistic Substudy of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE): Effects of pitavastatin on coronary artery disease and inflammatory biomarkers.

Journal article Am Heart J · June 2019 BACKGROUND: People with HIV (PWH) have increased cardiovascular events, inflammation, and high-risk coronary atherosclerosis. Statin therapy has been shown to lower the risk of cardiovascular disease (CVD) in the general population, but whether this result ... Full text Link to item Cite

Rationale and design of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE).

Journal article Am Heart J · June 2019 BACKGROUND: Cardiovascular disease (CVD) is more frequent among people with HIV (PWH) and may relate to traditional and nontraditional factors, including inflammation and immune activation. A critical need exists to develop effective strategies to prevent ... Full text Link to item Cite

The train has left: Can surgeons still get a ticket to treat structural heart disease?

Journal article J Thorac Cardiovasc Surg · June 2019 With the disruptive advancement of catheter-based technologies and minimally invasive techniques in structural heart disease, surgeons must obtain necessary skills to continue to serve this large patient population. We believe that surgeons are uniquely po ... Full text Link to item Cite

Racial Disparities in the Utilization and Outcomes of TAVR: TVT Registry Report.

Journal article JACC Cardiovasc Interv · May 27, 2019 OBJECTIVES: This study sought to evaluate racial disparities in the performance and outcomes of transcatheter aortic valve replacement (TAVR). BACKGROUND: Racial disparities in cardiovascular diseases are well described. Whether the racial disparities obse ... Full text Link to item Cite

Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients.

Journal article N Engl J Med · May 2, 2019 BACKGROUND: Among patients with aortic stenosis who are at intermediate or high risk for death with surgery, major outcomes are similar with transcatheter aortic-valve replacement (TAVR) and surgical aortic-valve replacement. There is insufficient evidence ... Full text Link to item Cite

Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial.

Journal article Eur Heart J Cardiovasc Imaging · May 1, 2019 AIMS: To update pretest probabilities (PTP) for obstructive coronary artery disease (CAD ≥ 50%) across age, sex, and clinical symptom strata, using coronary computed tomography angiography (CTA) in a large contemporary population of patients with stable ch ... Full text Link to item Cite

Commentary: How (and why) to make it mini.

Journal article J Thorac Cardiovasc Surg · May 2019 Full text Link to item Cite

Reply: hs-cTnI in Stable Chest Pain.

Journal article J Am Coll Cardiol · April 30, 2019 Full text Link to item Cite

Association of Statin Use and Mortality After Transcatheter Aortic Valve Replacement.

Journal article J Am Heart Assoc · April 16, 2019 Background Statins may reduce mortality after transcatheter aortic valve replacement (TAVR) through prevention of atherosclerotic events or pleiotropic effects. However, the competing mortality risks in TAVR patients may dilute any positive effect of stati ... Full text Link to item Cite

Development and Application of a Risk Prediction Model for In-Hospital Stroke After Transcatheter Aortic Valve Replacement: A Report From The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal article Ann Thorac Surg · April 2019 BACKGROUND: Stroke is a serious complication after transcatheter aortic valve replacement (TAVR), yet predictive models are not available. A new risk model for in-hospital stroke after TAVR was developed and used to estimate site-specific performance. METH ... Full text Link to item Cite

Initial Feasibility Study of a New Transcatheter Mitral Prosthesis: The First 100 Patients.

Journal article J Am Coll Cardiol · March 26, 2019 BACKGROUND: Transcatheter mitral valve replacement (TMVR) is a rapidly evolving therapy. Follow-up of TMVR patients remains limited in duration and number treated. OBJECTIVES: The purpose of this study was to examine outcomes with expanded follow-up for th ... Full text Link to item Cite

The Fate of Transcaval Access Tracts: 12-Month Results of the Prospective NHLBI Transcaval Transcatheter Aortic Valve Replacement Study.

Journal article JACC Cardiovasc Interv · March 11, 2019 OBJECTIVES: The authors investigated 1-year outcomes after transcaval access and closure for transcatheter aortic valve replacement (TAVR), using commercially available nitinol cardiac occluders off-label. BACKGROUND: Transcaval access is a fully percutane ... Full text Link to item Cite

The Vancouver 3M (Multidisciplinary, Multimodality, But Minimalist) Clinical Pathway Facilitates Safe Next-Day Discharge Home at Low-, Medium-, and High-Volume Transfemoral Transcatheter Aortic Valve Replacement Centers: The 3M TAVR Study.

Journal article JACC Cardiovasc Interv · March 11, 2019 OBJECTIVES: The authors sought to prospectively determine the safety and efficacy of next-day discharge using the Vancouver 3M (Multidisciplinary, Multimodality, but Minimalist) Clinical Pathway. BACKGROUND: Transfemoral transcatheter aortic valve replacem ... Full text Link to item Cite

Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease.

Journal article J Am Coll Cardiol · March 5, 2019 BACKGROUND: The optimal noninvasive test (NIT) for patients with diabetes and stable symptoms of coronary artery disease (CAD) is unknown. OBJECTIVES: The purpose of this study was to assess whether a diagnostic strategy based on coronary computed tomograp ... Full text Link to item Cite

Clinical Outcomes of Mitral Valve Reoperations in the United States: An Analysis of The Society of Thoracic Surgeons National Database.

Journal article Ann Thorac Surg · March 2019 BACKGROUND: This study evaluated outcomes of reoperative mitral valve surgery (MVS) in the United States. METHODS: Adults undergoing isolated MVS with prior open-heart operation in The Society of Thoracic Surgeons (STS) National Database between July 2011 ... Full text Link to item Cite

Primary Prevention of Heart Failure in Women.

Journal article JACC Heart Fail · March 2019 The incidence of heart failure (HF) is increasing, particularly among women, and constitutes a rapidly growing public health problem. The primary prevention of HF in women should involve targeted, sex-specific strategies to increase awareness, promote a he ... Full text Link to item Cite

Left Ventricular Hypertrophy Does Not Affect 1-Year Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement.

Journal article JACC Cardiovasc Interv · February 25, 2019 OBJECTIVES: The aim of this study was to evaluate the association between pre-procedural left ventricular hypertrophy (LVH) patterns and clinical outcomes after transcatheter aortic valve replacement (TAVR). BACKGROUND: The association between pre-procedur ... Full text Link to item Cite

Sex Differences in the Pursuit of Interventional Cardiology as a Subspecialty Among Cardiovascular Fellows-in-Training.

Journal article JACC Cardiovasc Interv · February 11, 2019 OBJECTIVES: The authors sought to determine the factors that influence fellows-in-training (FITs) to pursue a career in interventional cardiology (IC) and how these differ by sex. BACKGROUND: Despite increases in the proportion of women across numerous med ... Full text Link to item Cite

Sex differences in management and outcomes of patients with stable symptoms suggestive of coronary artery disease: Insights from the PROMISE trial.

Journal article Am Heart J · February 2019 BACKGROUND: Although sex differences exist in the management of acute coronary syndromes, less is known about the management and outcomes of women and men with suspected coronary artery disease being evaluated with noninvasive testing (NIT). METHODS: We in ... Full text Link to item Cite

NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF.

Journal article JACC Heart Fail · February 2019 OBJECTIVES: This study aims to assess the association between biomarker-guided therapy and left ventricular (LV) remodeling. BACKGROUND: In patients with heart failure with reduced ejection fraction (HFrEF), it is unclear if lowering natriuretic peptides r ... Full text Link to item Cite

Predictive Model for High-Risk Coronary Artery Disease.

Journal article Circ Cardiovasc Imaging · February 2019 BACKGROUND: Patients with high-risk coronary artery disease (CAD) may be difficult to identify. METHODS: Using the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) cohort randomized to coronary computed tomographic angiography ( ... Full text Link to item Cite

Omitted Potential Conflict of Interest Disclosures.

Journal article JAMA Cardiol · February 1, 2019 Full text Link to item Cite

Single-Molecule hsTnI and Short-Term Risk in Stable Patients With Chest Pain.

Journal article J Am Coll Cardiol · January 29, 2019 BACKGROUND: Evaluation of stable symptomatic outpatients with suspected coronary artery disease (CAD) may be challenging because they have a wide range of cardiovascular risk. The role of troponin testing to assist clinical decision making in this setting ... Full text Link to item Cite

Comprehensive Echocardiographic Assessment of Normal Transcatheter Valve Function.

Journal article JACC Cardiovasc Imaging · January 2019 OBJECTIVES: This study aims to establish parameters for identifying normal function for each of the 3 iterations of balloon-expandable valves and 2 iterations of self-expanding valves. BACKGROUND: Expected transthoracic echocardiographic Doppler-derived he ... Full text Link to item Cite

Effects of obesity on noninvasive test results in patients with suspected cardiac ischemia: Insights from the PROMISE trial.

Journal article J Cardiovasc Comput Tomogr · 2019 BACKGROUND: Obesity is a risk factor for coronary artery disease (CAD), but adiposity may mimic symptoms of CAD and reduce the accuracy of diagnostic testing. METHODS: Patients from the PROMISE trial (n = 8889) were classified according to body mass index ... Full text Link to item Cite

Transapical Approach for TAVR: Keep It in the Quiver.

Journal article Semin Thorac Cardiovasc Surg · 2019 Full text Link to item Cite

Imaging for Predicting and Assessing Prosthesis-Patient Mismatch After Aortic Valve Replacement.

Journal article JACC Cardiovasc Imaging · January 2019 Prosthesis-patient mismatch (PPM) occurs when the effective orifice area (EOA) of the prosthetic valve is too small in relation to a patient's body size, thus resulting in high residual postoperative pressure gradients across the prosthesis. Severe PPM occ ... Full text Link to item Cite

Sex differences in long-term outcomes of patients across the spectrum of coronary artery disease.

Journal article Am Heart J · December 2018 BACKGROUND: Patients with nonobstructive coronary artery disease (CAD) have worse outcomes compared with those without CAD; however, few studies have compared the intermediate- and long-term impact of CAD severity as a function of patient sex. METHODS: We ... Full text Link to item Cite

Pathological Remodeling of Mitral Valve Leaflets from Unphysiologic Leaflet Mechanics after Undersized Mitral Annuloplasty to Repair Ischemic Mitral Regurgitation.

Journal article J Am Heart Assoc · November 6, 2018 Background Undersized ring annuloplasty is a commonly used surgical repair for ischemic mitral regurgitation, in which annular downsizing corrects regurgitation, but alters valve geometry and elevates tissue stresses. In this study, we investigated if unph ... Full text Link to item Cite

The Impact of Mitral Disease Etiology on Operative Mortality After Mitral Valve Operations.

Journal article Ann Thorac Surg · November 2018 BACKGROUND: The pathoetiology of mitral regurgitation (MR) has been suggested as a mediator of outcomes after mitral valve (MV) operations, particularly in ischemic functional mitral regurgitation (IMR). This study examined the independent association of M ... Full text Link to item Cite

Crowdsourcing consensus: proposal of a novel method for assessing accuracy in echocardiography interpretation.

Journal article Int J Cardiovasc Imaging · November 2018 Quality in stress echocardiography interpretation is often gauged against coronary angiography (CA) data but anatomic obstructive coronary disease on CA is an imperfect gold standard for a stress induced wall motion abnormality. We examined the utility of ... Full text Link to item Cite

Clinical Utility and Prognostic Value of Right Atrial Function in Pulmonary Hypertension.

Journal article Circ Cardiovasc Imaging · November 2018 Background Although right atrial (RA) enlargement is an established marker for adverse outcomes, the prognostic importance of RA dysfunction independent of RA size in pulmonary arterial hypertension is not known. Methods and Results Study subjects with pul ... Full text Link to item Cite

Predictors of Surgical Intervention in Dialysis Patients With Infective Endocarditis.

Journal article Open Forum Infect Dis · November 2018 BACKGROUND: The use of valve surgery for infective endocarditis (IE) in end-stage renal disease (ESRD) patients may be different than in the general population. We assessed predictors of early surgery in ESRD patients with IE. METHODS: We conducted a retro ... Full text Link to item Cite

Early clinical results with the Tendyne transcatheter mitral valve replacement system.

Journal article Ann Cardiothorac Surg · November 2018 Transcatheter mitral valve replacement is an emerging technology for the treatment of mitral valve regurgitation. Numerous devices are in development and in various stages of clinical investigation. The Tendyne system (Tendyne Holdings, LLC, a subsidiary o ... Full text Link to item Cite

The Cardioband transcatheter annular reduction system.

Journal article Ann Cardiothorac Surg · November 2018 Surgical implantation of a complete or incomplete ring to reduce the mitral valve annulus and improve leaflet coaptation is the foundation of valve repair for degenerative and functional mitral and tricuspid regurgitation. The Cardioband system (Edwards Li ... Full text Link to item Cite

Association Between Hospital Surgical Aortic Valve Replacement Volume and Transcatheter Aortic Valve Replacement Outcomes.

Journal article JAMA Cardiol · November 1, 2018 IMPORTANCE: The Centers for Medicare & Medicaid Services national coverage determination for transcatheter aortic valve replacement (TAVR) includes volume requirements for surgical aortic valve replacement (SAVR) for hospitals seeking to initiate or contin ... Full text Link to item Cite

Clinical Characteristics, Procedural Factors, and Outcomes of Percutaneous Coronary Intervention in Patients With Mechanical and Bioprosthetic Heart Valves.

Journal article Am J Cardiol · November 1, 2018 There is scarcity of evidence regarding antiplatelet and anticoagulant therapy in patients with prosthetic valves undergoing percutaneous coronary intervention (PCI). Our goal was to compare clinical outcomes between patients with mechanical or bioprosthet ... Full text Link to item Cite

Maintenance of valvular integrity with Impella left heart support: Results from the multicenter PROTECT II randomized study.

Journal article Catheter Cardiovasc Interv · October 1, 2018 BACKGROUND: The Impella 2.5 axial flow pump, which is positioned across the aortic valve, is widely employed for hemodynamic support. The present study compared structural and functional integrity of the left heart valves in patients undergoing Impella vs ... Full text Link to item Cite

Aortic clamping strategy and postoperative stroke.

Journal article J Thorac Cardiovasc Surg · October 2018 OBJECTIVE: The effect of aortic clamping strategy on short-term stroke during proximal graft construction for coronary artery bypass grafting (CABG) remains undefined. The aim of this study was to test the hypothesis that partial occluding clamp (POC) tech ... Full text Link to item Cite

Variation in post-TAVR antiplatelet therapy utilization and associated outcomes: Insights from the STS/ACC TVT Registry.

Journal article Am Heart J · October 2018 BACKGROUND: Dual antiplatelet therapy (DAPT) is recommended following transcatheter aortic valve replacement (TAVR); however, the optimal antiplatelet strategy is undefined, and little is known about practice patterns. We aimed to describe contemporary pra ... Full text Link to item Cite

Is Off-Pump CABG Off Base?

Journal article J Am Coll Cardiol · September 25, 2018 Full text Link to item Cite

The Effect of Post-Dilatation on Outcomes in the PARTNER 2 SAPIEN 3 Registry.

Journal article JACC Cardiovasc Interv · September 10, 2018 OBJECTIVES: The purpose of this study was to understand the effects of balloon post-dilatation on outcomes following transcatheter aortic valve replacement with the SAPIEN 3 valve. BACKGROUND: Hemodynamics and outcomes with balloon post-dilatation for the ... Full text Link to item Cite

Incidence, Management, and Associated Clinical Outcomes of New-Onset Atrial Fibrillation Following Transcatheter Aortic Valve Replacement: An Analysis From the STS/ACC TVT Registry.

Journal article JACC Cardiovasc Interv · September 10, 2018 OBJECTIVES: The aim of this study was to evaluate incidence, care patterns, and clinical outcomes in patients developing new-onset atrial fibrillation (AF) following transcatheter aortic valve replacement (TAVR). BACKGROUND: Pre-procedural AF has been asso ... Full text Link to item Cite

A Tale of 2 Tests.

Journal article JACC Cardiovasc Imaging · September 2018 Full text Link to item Cite

Isolated Mitral Valve Surgery: The Society of Thoracic Surgeons Adult Cardiac Surgery Database Analysis.

Journal article Ann Thorac Surg · September 2018 BACKGROUND: Data from The Society of Thoracic Surgeons Adult Cardiac Surgery Database were analyzed to identify trends in patient characteristics and outcomes of mitral valve operations in North America. METHODS: All patients with isolated primary mitral v ... Full text Link to item Cite

Clinical and Echocardiographic Predictors of Outcomes in Patients With Pulmonary Hypertension.

Journal article Am J Cardiol · September 1, 2018 In pulmonary hypertension (PH), measurement of various echocardiographic parameters that assess right heart function is recommended by current clinical guidelines. Limited data exists on the combined value of clinical and echocardiographic parameters in pr ... Full text Link to item Cite

Comparison of International Guidelines for Assessment of Suspected Stable Angina: Insights From the PROMISE and SCOT-HEART.

Journal article JACC Cardiovasc Imaging · September 2018 OBJECTIVES: This study sought to compare the performance of major guidelines for the assessment of stable chest pain including risk-based (American College of Cardiology/American Heart Association and European Society of Cardiology) and symptom-focused (Na ... Full text Link to item Cite

Sternotomy closure using rigid plate fixation: a paradigm shift from wire cerclage.

Journal article Ann Cardiothorac Surg · September 2018 BACKGROUND: Rigid plate fixation (RPF) is the cornerstone in managing fractures and osteotomies except for sternotomy, where most cardiac surgeons continue to use wire cerclage (WC). Results of a multicenter randomized trial evaluating sternal healing, ste ... Full text Link to item Cite

Correction to: Imaging the myocardial ischemic cascade.

Journal article Int J Cardiovasc Imaging · September 2018 In the original publication of the article, the seventh author name "Matthias Gutberlet" has been misspelt. ... Full text Link to item Cite

Transcatheter therapies have not forgotten the tricuspid valve.

Journal article J Thorac Cardiovasc Surg · September 2018 Full text Link to item Cite

Career Preferences and Perceptions of Cardiology Among US Internal Medicine Trainees: Factors Influencing Cardiology Career Choice.

Journal article JAMA Cardiol · August 1, 2018 IMPORTANCE: Few data exist on internal medicine trainees' selection of cardiology training, although this is important for meeting future cardiology workforce needs. OBJECTIVE: To discover trainees' professional development preferences and perceptions of c ... Full text Link to item Cite

Transcatheter Aortic Valve Replacement of Failed Surgically Implanted Bioprostheses: The STS/ACC Registry.

Journal article J Am Coll Cardiol · July 24, 2018 BACKGROUND: Valve-in-valve (ViV) transcatheter aortic valve replacement (TAVR) has been shown to be feasible, yet the safety and efficacy in relation to native valve (NV) TAVR are not known. OBJECTIVES: This study sought to evaluate the safety and effectiv ... Full text Link to item Cite

Impact of Aortic Root Anatomy and Geometry on Paravalvular Leak in Transcatheter Aortic Valve Replacement With Extremely Large Annuli Using the Edwards SAPIEN 3 Valve.

Journal article JACC Cardiovasc Interv · July 23, 2018 OBJECTIVES: The aim of this study was to determine factors affecting paravalvular leak (PVL) in transcatheter aortic valve replacement (TAVR) with the Edwards SAPIEN 3 (S3) valve in extremely large annuli. BACKGROUND: The largest recommended annular area f ... Full text Link to item Cite

The incidence and prognostic implications of worsening right ventricular function after surgical or transcatheter aortic valve replacement: insights from PARTNER IIA.

Journal article Eur Heart J · July 21, 2018 AIMS: In patients randomized to transcatheter or surgical aortic valve replacement (TAVR, SAVR), we sought to determine whether SAVR is associated with worsening right ventricular (RV) function and whether RV deterioration is associated with mortality. MET ... Full text Link to item Cite

Usefulness and Cost-Effectiveness of Universal Echocardiographic Contrast to Detect Left Ventricular Thrombus in Patients with Heart Failure and Reduced Ejection Fraction.

Journal article Am J Cardiol · July 1, 2018 Contrast is a recommended but frequently unused tool in transthoracic echocardiography to improve detection of left ventricular thrombus in patients with ejection fraction (EF) ≤35%. The clinical and economic outcomes of a possible solution (i.e., universa ... Full text Link to item Cite

Who can we save after an intraprocedural catastrophe during TAVR?

Journal article Catheter Cardiovasc Interv · July 2018 Intraprocedural catastrophes during transcatheter aortic valve replacement (TAVR) are associated with a high mortality. Even "operable patients" can suddenly be deemed inoperable during an intraprocedural TAVR complication. The low incidence of a major com ... Full text Link to item Cite

The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2018 Update on Research: Outcomes Analysis, Quality Improvement, and Patient Safety.

Journal article Ann Thorac Surg · July 2018 The Society of Thoracic Surgeons Adult Cardiac Database (ACSD) is an international voluntary registry that provides adult cardiac surgery programs with risk-adjusted outcome reports for quality improvement. With more than 6,300,000 procedural records in ad ... Full text Link to item Cite

Outcomes Following Urgent/Emergent Transcatheter Aortic Valve Replacement: Insights From the STS/ACC TVT Registry.

Journal article JACC Cardiovasc Interv · June 25, 2018 OBJECTIVES: The authors sought to examine outcomes and identify independent predictors of mortality among patients undergoing urgent/emergent transcatheter aortic valve replacement (TAVR). BACKGROUND: Data on urgent/emergent TAVR as a rescue therapy for de ... Full text Link to item Cite

Effect of SAPIEN 3 Transcatheter Valve Implantation on Health Status in Patients With Severe Aortic Stenosis at Intermediate Surgical Risk: Results From the PARTNER S3i Trial.

Journal article JACC Cardiovasc Interv · June 25, 2018 OBJECTIVES: The aim of this study was to evaluate whether transcatheter aortic valve replacement (TAVR) with the SAPIEN 3 valve (S3-TAVR) results in improved quality of life (QoL) compared with previous-generation TAVR devices or surgical aortic valve repl ... Full text Link to item Cite

Associations Between Surgical Ablation and Operative Mortality After Mitral Valve Procedures.

Journal article Ann Thorac Surg · June 2018 BACKGROUND: Surgical ablation (SA) for atrial fibrillation (AF) concomitant to mitral valve repair/replacement (MVRR) improves longitudinal sinus rhythm. However, the risk of adding SA remains a clinical question. This study examined whether the addition o ... Full text Link to item Cite

Stroke and Cardiovascular Outcomes in Patients With Carotid Disease Undergoing Transcatheter Aortic Valve Replacement.

Journal article Circ Cardiovasc Interv · June 2018 BACKGROUND: Stroke is a serious complication of both transcatheter aortic valve replacement (TAVR) and carotid artery disease (CD). The implications of CD in patients undergoing TAVR are unclear. METHODS AND RESULTS: The Society of Thoracic Surgeons and Am ... Full text Link to item Cite

Epidemiology of new-onset atrial fibrillation following coronary artery bypass graft surgery.

Journal article Heart · June 2018 OBJECTIVES: Postoperative atrial fibrillation (AF) following coronary artery bypass graft surgery (CABG) is significantly associated with reduced survival, but poor characterisation and inconsistent definitions present barriers to developing effective prop ... Full text Link to item Cite

Single- Versus Multicenter Surgeons' Risk-Adjusted Coronary Artery Bypass Graft Procedural Outcomes.

Journal article Ann Thorac Surg · May 2018 BACKGROUND: Since 2010, 460+ hospital mergers have occurred in the United States, rerouting historical coronary artery bypass graft (CABG) referral patterns. The goals of this study were: (1) to compare risk-adjusted CABG outcomes between single-center ver ... Full text Link to item Cite

The Society of Thoracic Surgeons 2018 Adult Cardiac Surgery Risk Models: Part 2-Statistical Methods and Results.

Journal article Ann Thorac Surg · May 2018 BACKGROUND: The Society of Thoracic Surgeons (STS) uses statistical models to create risk-adjusted performance metrics for Adult Cardiac Surgery Database (ACSD) participants. Because of temporal changes in patient characteristics and outcomes, evolution of ... Full text Link to item Cite

The Society of Thoracic Surgeons 2018 Adult Cardiac Surgery Risk Models: Part 1-Background, Design Considerations, and Model Development.

Journal article Ann Thorac Surg · May 2018 BACKGROUND: The last published version of The Society of Thoracic Surgeons (STS) Adult Cardiac Surgery Database (ACSD) risk models were developed in 2008 based on patient data from 2002 to 2006 and have been periodically recalibrated. In response to evolvi ... Full text Link to item Cite

Central Core Laboratory versus Site Interpretation of Coronary CT Angiography: Agreement and Association with Cardiovascular Events in the PROMISE Trial.

Journal article Radiology · April 2018 Purpose To assess concordance and relative prognostic utility between central core laboratory and local site interpretation for significant coronary artery disease (CAD) and cardiovascular events. Materials and Methods In the Prospective Multicenter Imagin ... Full text Link to item Cite

Secondary surgical-site infection after coronary artery bypass grafting: A multi-institutional prospective cohort study.

Journal article J Thorac Cardiovasc Surg · April 2018 OBJECTIVE: To analyze patient risk factors and processes of care associated with secondary surgical-site infection (SSI) after coronary artery bypass grafting (CABG). METHODS: Data were collected prospectively between February and October 2010 for consenti ... Full text Link to item Cite

Association of Tricuspid Regurgitation With Transcatheter Aortic Valve Replacement Outcomes: A Report From The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal article Ann Thorac Surg · April 2018 BACKGROUND: The purpose of this study is to evaluate the association of tricuspid regurgitation (TR) severity with outcomes after transcatheter aortic valve replacement (TAVR). METHODS: We analyzed data from 34,576 patients who underwent TAVR at 365 US hos ... Full text Link to item Cite

Inclusion of Functional Status Measures in the Risk Adjustment of 30-Day Mortality After Transcatheter Aortic Valve Replacement: A Report From the Society of Thoracic Surgeons/American College of Cardiology TVT Registry.

Journal article JACC Cardiovasc Interv · March 26, 2018 OBJECTIVES: The aim of this study was to develop and validate a risk adjustment model for 30-day mortality after transcatheter aortic valve replacement (TAVR) that accounted for both standard clinical factors and pre-procedural health status and frailty. B ... Full text Link to item Cite

The External Validity of Prediction Models for the Diagnosis of Obstructive Coronary Artery Disease in Patients With Stable Chest Pain: Insights From the PROMISE Trial.

Journal article JACC Cardiovasc Imaging · March 2018 OBJECTIVES: This study sought to externally validate prediction models for the presence of obstructive coronary artery disease (CAD). BACKGROUND: A better assessment of the probability of CAD may improve the identification of patients who benefit from noni ... Full text Link to item Cite

Echocardiography Core Laboratory Reproducibility of Cardiac Safety Assessments in Cardio-Oncology.

Journal article J Am Soc Echocardiogr · March 2018 BACKGROUND: As the potential for cancer therapy-related cardiac dysfunction is increasingly recognized, there is a need for the standardization of echocardiographic measurements and cut points to guide treatment. The aim of this study was to determine the ... Full text Link to item Cite

Identification of patients with stable chest pain deriving minimal value from coronary computed tomography angiography: An external validation of the PROMISE minimal-risk tool.

Journal article Int J Cardiol · February 1, 2018 BACKGROUND: The PROspective Multicenter Imaging Study for Evaluation of chest pain (PROMISE) minimal-risk tool was recently developed to identify patients with suspected stable angina at very low risk of coronary artery disease (CAD) and clinical events. W ... Full text Link to item Cite

Use of High-Risk Coronary Atherosclerotic Plaque Detection for Risk Stratification of Patients With Stable Chest Pain: A Secondary Analysis of the PROMISE Randomized Clinical Trial.

Journal article JAMA Cardiol · February 1, 2018 IMPORTANCE: Coronary computed tomographic angiography (coronary CTA) can characterize coronary artery disease, including high-risk plaque. A noninvasive method of identifying high-risk plaque before major adverse cardiovascular events (MACE) could provide ... Full text Link to item Cite

Lower likelihood of cardiac procedures after acute coronary syndrome in patients with human immunodeficiency virus/acquired immunodeficiency syndrome.

Journal article Medicine (Baltimore) · February 2018 Cardiovascular disease (CVD) is an increasing cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected adults; however, this population may be less likely to receive interventions during hospitalization for acute coronary syndrome (A ... Full text Open Access Link to item Cite

The Authors Reply.

Journal article JACC Cardiovasc Imaging · February 2018 Full text Link to item Cite

Sex-Specific Outcomes of Transcatheter Aortic Valve Replacement With the SAPIEN 3 Valve: Insights From the PARTNER II S3 High-Risk and Intermediate-Risk Cohorts.

Journal article JACC Cardiovasc Interv · January 8, 2018 OBJECTIVES: The purpose of this study was to identify sex-specific outcomes of intermediate risk patients undergoing transcatheter aortic valve replacement with the SAPIEN 3 valve. BACKGROUND: A survival difference has been observed in women as compared wi ... Full text Link to item Cite

Valve hemodynamic deterioration and cardiovascular outcomes in TAVR: A report from the STS/ACC TVT Registry.

Journal article Am Heart J · January 2018 BACKGROUND: Recent reports of leaflet abnormalities (detected using advanced imaging) have raised questions regarding transcatheter aortic valve replacement (TAVR) durability. We sought to determine the incidence of valve hemodynamic deterioration (VHD) an ... Full text Link to item Cite

Contemporary management and outcomes of acute type A aortic dissection: An analysis of the STS adult cardiac surgery database.

Journal article J Card Surg · January 2018 PURPOSE: Management of acute type A aortic dissection (AAAD) is challenging and operative strategies are varied. We used the STS Adult Cardiac Surgery Database (STS ACSD) to describe contemporary surgical strategies and outcomes for AAAD. METHODS: Between ... Full text Link to item Cite

Pulmonary Heart Valves: Redefining Outcomes.

Journal article Semin Thorac Cardiovasc Surg · 2018 Full text Link to item Cite

With Every New Technology Comes a Learning Curve.

Journal article Semin Thorac Cardiovasc Surg · 2018 Full text Link to item Cite

Transapical Transcatheter Aortic Valve Replacement Is Associated With Increased Cardiac Mortality in Patients With Left Ventricular Dysfunction: Insights From the PARTNER I Trial.

Journal article JACC Cardiovasc Interv · December 11, 2017 OBJECTIVES: The authors sought to evaluate the impact of transapical (TA) transcatheter aortic valve replacement (TAVR) on mortality, left ventricular (LV) ejection fraction (LVEF) improvement, and functional recovery in patients with LV dysfunction. BACKG ... Full text Link to item Cite

Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research.

Journal article Glob Heart · December 2017 Almost three-quarters (74%) of all the noncommunicable disease burden is found within low- and middle-income countries. In September 2014, the National Heart, Lung, and Blood Institute held a Global Health Think Tank meeting to obtain expert advice and rec ... Full text Link to item Cite

Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis and Mitral Regurgitation.

Journal article Ann Thorac Surg · December 2017 BACKGROUND: Many patients undergoing transcatheter aortic valve replacement (TAVR) for aortic stenosis also have significant mitral regurgitation (MR). We sought to understand the association of concomitant MR with TAVR clinical outcomes, as well changes i ... Full text Link to item Cite

Staging classification of aortic stenosis based on the extent of cardiac damage.

Journal article Eur Heart J · December 1, 2017 AIMS: In patients with aortic stenosis (AS), risk stratification for aortic valve replacement (AVR) relies mainly on valve-related factors, symptoms and co-morbidities. We sought to evaluate the prognostic impact of a newly-defined staging classification c ... Full text Link to item Cite

Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.

Journal article Circ Heart Fail · December 2017 BACKGROUND: Mitochondrial dysfunction and energy depletion in the failing heart are innovative therapeutic targets in heart failure management. Elamipretide is a novel tetrapeptide that increases mitochondrial energy; however, its safety, tolerability, and ... Full text Link to item Cite

Prognostic Value of Coronary Artery Calcium in the PROMISE Study (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).

Journal article Circulation · November 21, 2017 BACKGROUND: Coronary artery calcium (CAC) is an established predictor of future major adverse atherosclerotic cardiovascular events in asymptomatic individuals. However, limited data exist as to how CAC compares with functional testing (FT) in estimating p ... Full text Link to item Cite

Outcomes With Transcatheter Mitral Valve Repair in the United States: An STS/ACC TVT Registry Report.

Journal article J Am Coll Cardiol · November 7, 2017 BACKGROUND: Post-market surveillance is needed to evaluate the real-world clinical effectiveness and safety of U.S. Food and Drug Administration-approved devices. OBJECTIVES: The authors examined the commercial experience with transcatheter mitral valve re ... Full text Link to item Cite

Noninvasive FFR Derived From Coronary CT Angiography: Management and Outcomes in the PROMISE Trial.

Journal article JACC Cardiovasc Imaging · November 2017 OBJECTIVES: The purpose of this study was to determine whether noninvasive fractional flow reserve derived from computed tomography (FFRCT) predicts coronary revascularization and outcomes and whether its addition improves efficiency of referral to invasiv ... Full text Link to item Cite

Longitudinal Hemodynamics of Transcatheter and Surgical Aortic Valves in the PARTNER Trial.

Journal article JAMA Cardiol · November 1, 2017 IMPORTANCE: Use of transcatheter aortic valve replacement (TAVR) for severe aortic stenosis is growing rapidly. However, to our knowledge, the durability of these prostheses is incompletely defined. OBJECTIVE: To determine the midterm hemodynamic performan ... Full text Link to item Cite

Clinical Impact of Diabetes Mellitus on Outcomes After Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal article Circ Cardiovasc Interv · November 2017 BACKGROUND: Diabetes mellitus (DM) adversely affects morbidity and mortality for cardiovascular diseases and procedures. Data evaluating the outcomes of transcatheter aortic valve replacement (TAVR) in diabetic patients are limited by small sample size and ... Full text Link to item Cite

Impact of Diabetes Mellitus on the Evaluation of Stable Chest Pain Patients: Insights From the PROMISE (Prospective Multicenter Imaging Study for Evaluation of Chest Pain) Trial.

Journal article J Am Heart Assoc · October 31, 2017 BACKGROUND: The impact of diabetes mellitus on the clinical presentation and noninvasive test (NIT) results among stable outpatients presenting with symptoms suggestive of coronary artery disease (CAD) has not been well described. METHODS AND RESULTS: The ... Full text Link to item Cite

Conversion From Off-Pump Coronary Artery Bypass Grafting to On-Pump Coronary Artery Bypass Grafting.

Journal article Ann Thorac Surg · October 2017 BACKGROUND: Off-pump coronary artery bypass grafting (OPCAB) has been shown to be an effective strategy for surgical revascularization. The purpose of this study was to define the incidence of intraoperative conversion from OPCAB to on-pump coronary artery ... Full text Link to item Cite

SPECT, PET, and CTA-Acronyms or Better Imaging?

Journal article JAMA Cardiol · October 1, 2017 Full text Link to item Cite

Peripheral Artery Disease and Transcatheter Aortic Valve Replacement Outcomes: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Therapy Registry.

Journal article Circ Cardiovasc Interv · October 2017 BACKGROUND: Peripheral artery disease (PAD) is associated with increased cardiovascular mortality, and PAD risk factors overlap with those for aortic stenosis. The prevalence and outcomes associated with PAD in a population undergoing transcatheter aortic ... Full text Link to item Cite

Quantifying sociodemographic and income disparities in medical therapy and lifestyle among symptomatic patients with suspected coronary artery disease: a cross-sectional study in North America.

Journal article BMJ Open · September 29, 2017 OBJECTIVES: To evaluate potential gaps in preventive medical therapy and healthy lifestyle practices among symptomatic patients with suspected coronary artery disease (CAD) seeing primary care physicians and cardiologists and how gaps vary by sociodemograp ... Full text Link to item Cite

Diversity Matters.

Journal article J Am Coll Cardiol · September 19, 2017 Full text Link to item Cite

Hypothermia and cerebral protection strategies in aortic arch surgery: a comparative effectiveness analysis from the STS Adult Cardiac Surgery Database.

Journal article Eur J Cardiothorac Surg · September 1, 2017 OBJECTIVES: Hypothermic circulatory arrest is essential to aortic arch surgery, although consensus regarding optimal cerebral protection strategy remains lacking. We evaluated the current use and comparative effectiveness of hypothermia/cerebral perfusion ... Full text Link to item Cite

Physician Attitudes toward the First Pediatric Appropriate Use Criteria and Engagement With Educational Intervention to Improve the Appropriateness of Outpatient Echocardiography.

Journal article J Am Soc Echocardiogr · September 2017 BACKGROUND: A survey of pediatric cardiologists who participated in the Pediatric Appropriate Use of Echocardiography study was conducted to assess attitudes toward appropriate use criteria (AUC) and the relationship between perceptions of usefulness of a ... Full text Link to item Cite

CT-Defined Prosthesis-Patient Mismatch Downgrades Frequency and Severity, and Demonstrates No Association With Adverse Outcomes After Transcatheter Aortic Valve Replacement.

Journal article JACC Cardiovasc Interv · August 14, 2017 OBJECTIVES: This study sought to determine if indexed effective orifice area (EOAi), using left ventricular outflow tract measured from computed tomography (EOAiCT), reclassified prosthesis-patient mismatch (PPM) compared with conventional echocardiogram-d ... Full text Link to item Cite

Effect of Cerebral Embolic Protection Devices on CNS Infarction in Surgical Aortic Valve Replacement: A Randomized Clinical Trial.

Journal article JAMA · August 8, 2017 IMPORTANCE: Stroke is a major complication of surgical aortic valve replacement (SAVR). OBJECTIVE: To determine the efficacy and adverse effects of cerebral embolic protection devices in reducing ischemic central nervous system (CNS) injury during SAVR. DE ... Full text Link to item Cite

Transcatheter Versus Surgical Aortic Valve Replacement: Propensity-Matched Comparison.

Journal article J Am Coll Cardiol · July 25, 2017 BACKGROUND: Randomized trials support the use of transcatheter aortic valve replacement (TAVR) for the treatment of aortic stenosis in high- and intermediate-risk patients, but the generalizability of those results in clinical practice has been challenged. ... Full text Link to item Cite

The Society of Thoracic Surgeons Adult Cardiac Surgery Database: 2017 Update on Research.

Journal article Ann Thorac Surg · July 2017 Containing more than 6 million cumulative operative records and accounting for 90% to 95% of adult cardiac surgery performed in the United States, The Society of Thoracic Surgeons Adult Cardiac Surgery Database is an invaluable resource for performance ass ... Full text Link to item Cite

Blood Pressure and Arterial Load After Transcatheter Aortic Valve Replacement for Aortic Stenosis.

Journal article Circ Cardiovasc Imaging · July 2017 BACKGROUND: After aortic valve replacement, left ventricular afterload is often characterized by the residual valve obstruction. Our objective was to determine whether higher systemic arterial afterload-as reflected in blood pressure, pulsatile and resisti ... Full text Link to item Cite

Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain: Insights From the PROMISE Trial (Prospective Multicenter Imaging Study for Evaluation of Chest Pain).

Journal article Circulation · June 13, 2017 BACKGROUND: Optimal management of patients with stable chest pain relies on the prognostic information provided by noninvasive cardiovascular testing, but there are limited data from randomized trials comparing anatomic with functional testing. METHODS: In ... Full text Link to item Cite

Pneumonia after cardiac surgery: Experience of the National Institutes of Health/Canadian Institutes of Health Research Cardiothoracic Surgical Trials Network.

Journal article J Thorac Cardiovasc Surg · June 2017 RATIONALE: Pneumonia remains the most common major infection after cardiac surgery despite numerous preventive measures. OBJECTIVES: To prospectively examine the timing, pathogens, and risk factors, including modifiable management practices, for postoperat ... Full text Link to item Cite

Application of the Pediatric Appropriate Use Criteria for Chest Pain.

Journal article J Pediatr · June 2017 OBJECTIVES: To characterize the subgroup of outpatient pediatric patients presenting with chest pain and to determine the effectiveness of published pediatric appropriate use criteria (PAUC) to detect pathology. STUDY DESIGN: The Pediatric Appropriate Use ... Full text Link to item Cite

Educational intervention for improving the appropriateness of transthoracic echocardiograms ordered by pediatric cardiologists.

Journal article Congenit Heart Dis · May 2017 OBJECTIVE: The objective of this study was to evaluate effectiveness of educational intervention (EI) in the Pediatric Appropriate Use of Echocardiography (PAUSE) study to improve appropriateness of transthoracic echocardiograms (TTEs) ordered in pediatric ... Full text Link to item Cite

Computed Tomography-Based Oversizing Degrees and Incidence of Paravalvular Regurgitation of a New Generation Transcatheter Heart Valve.

Journal article JACC Cardiovasc Interv · April 24, 2017 OBJECTIVES: The aim of the study was to investigate the influence of the extent of computed tomography (CT)-based area and perimeter oversizing on the incidence and severity of paravalvular aortic regurgitation (PAR) for the Edwards SAPIEN 3 (Edwards Lifes ... Full text Link to item Cite

Cardiovascular Function in Long-Term Hematopoietic Cell Transplantation Survivors.

Journal article Biol Blood Marrow Transplant · April 2017 Peak oxygen consumption (VO2peak), as measured by cardiopulmonary exercise testing (CPET), is a powerful independent predictor of cardiovascular disease (CVD) and all-cause mortality in a broad range of populations. We assessed the safety and feasibility o ... Full text Link to item Cite

Identification of Patients With Stable Chest Pain Deriving Minimal Value From Noninvasive Testing: The PROMISE Minimal-Risk Tool, A Secondary Analysis of a Randomized Clinical Trial.

Journal article JAMA Cardiol · April 1, 2017 IMPORTANCE: Guidelines recommend noninvasive testing for patients with stable chest pain, although many subsequently have normal test results and no adverse clinical events. OBJECTIVE: To describe a risk tool developed to use only pretest clinical data to ... Full text Link to item Cite

2016 Annual Report of The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal article J Am Coll Cardiol · March 14, 2017 BACKGROUND: The Society of Thoracic Surgeons (STS)/American College of Cardiology Transcatheter Valve Therapy (TVT) Registry captures all procedures with Food and Drug Administration-approved transcatheter valve devices performed in the United States, and ... Full text Link to item Cite

Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline.

Journal article J Clin Oncol · March 10, 2017 Purpose Cardiac dysfunction is a serious adverse effect of certain cancer-directed therapies that can interfere with the efficacy of treatment, decrease quality of life, or impact the actual survival of the patient with cancer. The purpose of this effort w ... Full text Link to item Cite

Application of pediatric appropriate use criteria for initial outpatient evaluation of syncope.

Journal article Echocardiography · March 2017 BACKGROUND: Syncope is a common reason for outpatient transthoracic echocardiography (TTE). We studied the applicability of pediatric appropriate use criteria (AUC) on initial outpatient evaluation of children (≤18 years) with syncope. METHODS: Data were o ... Full text Link to item Cite

2016 Annual Report of The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal article Ann Thorac Surg · March 2017 BACKGROUND: The Society of Thoracic Surgeons (STS)/American College of Cardiology Transcatheter Valve Therapy (TVT) Registry captures all procedures with Food and Drug Administration-approved transcatheter valve devices performed in the United States, and ... Full text Link to item Cite

Randomized Trials in Cardiovascular Imaging: Where to Next?

Journal article JACC Cardiovasc Imaging · March 2017 Full text Link to item Cite

Outcomes-Based CV Imaging Research Endpoints and Trial Design: From Pixels to Patient Satisfaction.

Journal article JACC Cardiovasc Imaging · March 2017 The categories and quality of evidence documenting the value of noninvasive cardiovascular imaging have evolved substantially over the last several decades. From an initial emphasis on the diagnostic accuracy of various imaging modalities, cardiovascular i ... Full text Link to item Cite

Comparative Effectiveness Trials of Imaging-Guided Strategies in Stable Ischemic Heart Disease.

Journal article JACC Cardiovasc Imaging · March 2017 The evaluation of patients with suspected stable ischemic heart disease is among the most common diagnostic evaluations with nearly 20 million imaging and exercise stress tests performed annually in the United States. Over the past decade, there has been a ... Full text Link to item Cite

Follow YOUR Heart: development of an evidence-based campaign empowering older women with HIV to participate in a large-scale cardiovascular disease prevention trial.

Journal article HIV Clin Trials · March 2017 BACKGROUND: Women's under-representation in HIV and cardiovascular disease (CVD) research suggests a need for novel strategies to ensure robust representation of women in HIV-associated CVD research. OBJECTIVE: To elicit perspectives on CVD research partic ... Full text Link to item Cite

Comparison of visual assessment of coronary stenosis with independent quantitative coronary angiography: Findings from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Journal article Am Heart J · February 2017 BACKGROUND: The outcomes in patients by visual assessment and quantitative coronary angiography (QCA) for obstructive coronary artery disease (CAD) are not known. Our objectives were to compare visual and QCA estimates of obstructive CAD and to assess thei ... Full text Link to item Cite

An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial.

Journal article Am Heart J · February 2017 BACKGROUND: Identifying predictors of coronary artery disease (CAD)-related procedures and events remains a priority. METHODS: We measured an age- and sex-specific gene expression score (ASGES) previously validated to detect obstructive CAD (oCAD) in sympt ... Full text Link to item Cite

Changes in the Professional Lives of Cardiologists Over 2 Decades.

Journal article J Am Coll Cardiol · January 31, 2017 The American College of Cardiology third decennial Professional Life Survey was completed by 2,313 cardiologists: 964 women (42%) and 1,349 men (58%). Compared with 10 and 20 years ago, current results reflect a substantially lower response rate (21% vs. 3 ... Full text Link to item Cite

The Author Replies.

Journal article JACC Cardiovasc Imaging · January 2017 Full text Link to item Cite

The medically managed patient with severe symptomatic aortic stenosis in the TAVR era: Patient characteristics, reasons for medical management, and quality of shared decision making at heart valve treatment centers.

Journal article PLoS One · 2017 BACKGROUND: Little is known about patients with severe symptomatic aortic stenosis (AS) who receive medical management despite evaluation at a heart valve treatment center. OBJECTIVE: We identified patient characteristics associated with medical management ... Full text Link to item Cite

An FFRCT diagnostic strategy versus usual care in patients with suspected coronary artery disease planned for invasive coronary angiography at German sites: one-year results of a subgroup analysis of the PLATFORM (Prospective Longitudinal Trial of FFRCT: Outcome and Resource Impacts) study.

Journal article Open Heart · 2017 AIM: Diagnostic evaluation practices for suspected coronary artery disease (CAD) may vary between countries. Our objective was to compare a CT-derived fractional flow reserve (FFRCT) diagnostic strategy with usual care in patients with planned invasive cor ... Full text Link to item Cite

Safety of coronary CT angiography and functional testing for stable chest pain in the PROMISE trial: A randomized comparison of test complications, incidental findings, and radiation dose.

Journal article J Cardiovasc Comput Tomogr · 2017 BACKGROUND: Coronary computed tomography angiography (CTA) and functional testing strategies for stable chest pain yield similar outcomes; one aspect that may guide test choice is safety. METHODS: We compared test safety (test complications, incidental fin ... Full text Open Access Link to item Cite

Long-Term Valve Performance of TAVR and SAVR: A Report From the PARTNER I Trial.

Journal article JACC Cardiovasc Imaging · December 8, 2016 OBJECTIVES: The aim of this study was to evaluate the long-term performance of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) through longitudinal echocardiographic analysis. BACKGROUND: The long-term performance ... Full text Link to item Cite

Choice of agreement indices for assessing and improving measurement reproducibility in a core laboratory setting.

Journal article Stat Methods Med Res · December 2016 Clinical core laboratories, such as Echocardiography core laboratories, are increasingly used in clinical studies with imaging outcomes as primary, secondary, or surrogate endpoints. While many factors contribute to the quality of measurements of imaging v ... Full text Link to item Cite

Critical Review of Current Approaches for Echocardiographic Reproducibility and Reliability Assessment in Clinical Research.

Journal article J Am Soc Echocardiogr · December 2016 BACKGROUND: There is no broadly accepted standard method for assessing the quality of echocardiographic measurements in clinical research reports, despite the recognized importance of this information in assessing the quality of study results. METHODS: Twe ... Full text Open Access Link to item Cite

The Society of Thoracic Surgeons National Database 2016 Annual Report.

Journal article Ann Thorac Surg · December 2016 The art and science of outcomes analysis, quality improvement, and patient safety continue to evolve, and cardiothoracic surgery leads many of these advances. The Society of Thoracic Surgeons (STS) National Database is one of the principal reasons for this ... Full text Link to item Cite

Antianginal medications and long-term outcomes after elective catheterization in patients with coronary artery disease.

Journal article Clin Cardiol · December 2016 BACKGROUND: Antianginal medications are a class I recommendation by the American College of Cardiology/American Heart Association guidelines for stable ischemic heart disease. We sought to better understand guidance in drug selection and real-life outcomes ... Full text Link to item Cite

Effect of Release of the First Pediatric Appropriate Use Criteria on Transthoracic Echocardiogram Ordering Practice.

Journal article Am J Cardiol · November 15, 2016 Pediatric appropriate use criteria (AUC) were recently published for initial outpatient transthoracic echocardiography (TTE). The purpose of this study was to determine the effect of AUC publication on TTE ordering patterns of pediatric cardiologists. Data ... Full text Link to item Cite

Changes in Medical Therapy and Lifestyle After Anatomical or Functional Testing for Coronary Artery Disease.

Journal article J Am Heart Assoc · October 12, 2016 BACKGROUND: Diagnostic testing in the care of patients newly presenting with symptoms suggestive of coronary artery disease may influence risk factor management, independent of test type or test results. However, little is known about changes in medication ... Full text Open Access Link to item Cite

Rationale and design of the Children's Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure.

Journal article BMC Cardiovasc Disord · October 4, 2016 BACKGROUND: Anthracyclines are widely used in the treatment of childhood cancer. One of the well-recognized side-effects of anthracycline therapy is dose-dependent cardiomyopathy that may progress to heart failure (HF) years after completion of cancer-dire ... Full text Link to item Cite

The Future of Cardiac Imaging: Report of a Think Tank Convened by the American College of Cardiology.

Journal article JACC Cardiovasc Imaging · October 2016 The American College of Cardiology's Executive Committee and Cardiovascular Imaging Section Leadership Council convened a discussion regarding the future of cardiac imaging among thought leaders in the field during a 2 day Think Tank. Participants were cha ... Full text Link to item Cite

Variation in Warfarin Use at Hospital Discharge After Isolated Bioprosthetic Mitral Valve Replacement: An Analysis of the Society of Thoracic Surgeons Adult Cardiac Surgery Database.

Journal article Chest · September 2016 BACKGROUND: Anticoagulation with warfarin following bioprosthetic mitral valve replacement (BMVR) is recommended by multiple practice guidelines. We assessed practice variability and patient characteristics associated with warfarin prescription following B ... Full text Link to item Cite

Variation in Hospital Risk-Adjusted Mortality Rates Following Transcatheter Aortic Valve Replacement in the United States: A Report From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry.

Journal article Circ Cardiovasc Qual Outcomes · September 2016 BACKGROUND: The use of transcatheter aortic valve replacement (TAVR) to treat aortic stenosis in the United States is growing, yet little is known about the variation in procedural outcomes in community practice. We developed a TAVR in-hospital mortality r ... Full text Link to item Cite

Bioabsorbable Intracoronary Matrix for Prevention of Ventricular Remodeling After Myocardial Infarction.

Journal article J Am Coll Cardiol · August 16, 2016 BACKGROUND: Bioabsorbable cardiac matrix (BCM) is a novel device that attenuates adverse left ventricular (LV) remodeling after large myocardial infarctions in experimental models. OBJECTIVES: This study aimed to analyze whether BCM, compared with saline c ... Full text Link to item Cite

1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease: The PLATFORM Study.

Journal article J Am Coll Cardiol · August 2, 2016 BACKGROUND: Coronary computed tomographic angiography (CTA) plus estimation of fractional flow reserve using CTA (FFRCT) safely and effectively guides initial care over 90 days in patients with stable chest pain. Longer-term outcomes are unknown. OBJECTIVE ... Full text Link to item Cite

Statin Utilization and Recommendations Among HIV- and HCV-infected Veterans: A Cohort Study.

Journal article Clin Infect Dis · August 1, 2016 BACKGROUND: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections are associated with increased risk of cardiovascular disease (CVD). The potential impact of recently updated cholesterol guidelines on treatment of HIV- and HCV-infected ... Full text Link to item Cite

Evaluation of Flow After Transcatheter Aortic Valve Replacement in Patients With Low-Flow Aortic Stenosis: A Secondary Analysis of the PARTNER Randomized Clinical Trial.

Journal article JAMA Cardiol · August 1, 2016 IMPORTANCE: Low-flow (LF) severe aortic stenosis (AS) is an independent predictor of mortality in patients undergoing aortic valve replacement (AVR). Little is known about improvement in flow after AVR and its effects on survival. OBJECTIVE: To determine w ... Full text Link to item Cite

Economic Outcomes With Anatomical Versus Functional Diagnostic Testing for Coronary Artery Disease.

Journal article Ann Intern Med · July 19, 2016 BACKGROUND: PROMISE (PROspective Multicenter Imaging Study for Evaluation of Chest Pain) found that initial use of at least 64-slice multidetector computed tomography angiography (CTA) versus functional diagnostic testing strategies did not improve clinica ... Full text Open Access Link to item Cite

One-Year Clinical Outcomes With SAPIEN 3 Transcatheter Aortic Valve Replacement in High-Risk and Inoperable Patients With Severe Aortic Stenosis.

Journal article Circulation · July 12, 2016 BACKGROUND: In the initial PARTNER trial (Placement of Aortic Transcatheter Valves) of transcatheter aortic valve replacement for high-risk (HR) and inoperable patients, mortality at 1 year was 24% in HR and 31% in inoperable patients. A recent report of t ... Full text Link to item Cite

Echocardiographic agreement in the diagnostic evaluation for infective endocarditis.

Journal article Int J Cardiovasc Imaging · July 2016 Echocardiography is essential for the diagnosis and management of infective endocarditis (IE). However, the reproducibility for the echocardiographic assessment of variables relevant to IE is unknown. Objectives of this study were: (1) To define the reprod ... Full text Link to item Cite

RESPONSE: Justified Optimism or Magical Thinking?

Journal article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · June 28, 2016 Link to item Cite

Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease.

Journal article J Am Coll Cardiol · June 7, 2016 BACKGROUND: Although risk stratification is an important goal of cardiac noninvasive tests (NITs), few contemporary data exist on the prognostic value of different NITs according to patient sex. OBJECTIVES: The goal of this study was to compare the results ... Full text Link to item Cite

Cardio-Oncology Training: A Proposal From the International Cardioncology Society and Canadian Cardiac Oncology Network for a New Multidisciplinary Specialty.

Journal article J Card Fail · June 2016 There is an increasing awareness and clinical interest in cardiac safety during cancer therapy as well as in optimally addressing cardiac issues in cancer survivors. Although there is an emerging expertise in this area, known as cardio-oncology, there is a ... Full text Link to item Cite

Quality-of-Life Outcomes With Anatomic Versus Functional Diagnostic Testing Strategies in Symptomatic Patients With Suspected Coronary Artery Disease: Results From the PROMISE Randomized Trial.

Journal article Circulation · May 24, 2016 BACKGROUND: The Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial found that initial use of ≥64 detector-row computed tomography angiography versus standard functional testing strategies (exercise ECG, stress nuclear method ... Full text Link to item Cite

Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation.

Journal article N Engl J Med · May 19, 2016 BACKGROUND: In a trial comparing coronary-artery bypass grafting (CABG) alone with CABG plus mitral-valve repair in patients with moderate ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index ( ... Full text Link to item Cite

Coronary CT Angiography as a Diagnostic and Prognostic Tool: Perspective from a Multicenter Randomized Controlled Trial: PROMISE.

Journal article Curr Cardiol Rep · May 2016 The PROMISE (Prospective multicenter imaging study for evaluation of chest pain) trial compared the effectiveness of coronary CT angiography and functional testing as initial diagnostic test for patients with suspicion for stable coronary artery disease (C ... Full text Link to item Cite

Optimal non-invasive imaging test selection for the diagnosis of ischaemic heart disease.

Journal article Heart · April 2016 The prevalence of angina is high in the general population, and increases with age in both sexes. Little consensus exists about which test is preferable when one is required for diagnosis, including significant differences in the current US and European gu ... Full text Link to item Cite

Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community-Based Retrospective Cohort Study.

Journal article J Clin Oncol · April 1, 2016 PURPOSE: Cardiovascular diseases (CVDs), including ischemic heart disease, stroke, and heart failure, are well-established late effects of therapy in survivors of childhood and young adult (< 40 years at diagnosis) cancers; less is known regarding CVD in l ... Full text Link to item Cite

Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial.

Journal article JACC Cardiovasc Imaging · April 2016 OBJECTIVES: The aim of this study was to determine whether presentation, risk assessment, testing choices, and results differ by sex in stable symptomatic outpatients with suspected coronary artery disease (CAD). BACKGROUND: Although established CAD presen ... Full text Link to item Cite

Assessment of Device-Related Thrombus and Associated Clinical Outcomes With the WATCHMAN Left Atrial Appendage Closure Device for Embolic Protection in Patients With Atrial Fibrillation (from the PROTECT-AF Trial).

Journal article Am J Cardiol · April 1, 2016 Left atrial appendage closure with the WATCHMAN device is an alternative to anticoagulation for stroke prevention in selected patients with atrial fibrillation (AF). LA device-related thrombus (DRT) is poorly defined and understood. We aimed to (1) develop ... Full text Link to item Cite

Development and Validation of a Risk Prediction Model for In-Hospital Mortality After Transcatheter Aortic Valve Replacement.

Journal article JAMA Cardiol · April 1, 2016 IMPORTANCE: Patient selection for transcatheter aortic valve replacement (TAVR) should include assessment of the risks of TAVR compared with surgical aortic valve replacement (SAVR). Existing SAVR risk models accurately predict the risks for the population ... Full text Link to item Cite

Sex-Specific Differences at Presentation and Outcomes Among Patients Undergoing Transcatheter Aortic Valve Replacement: A Cohort Study.

Journal article Ann Intern Med · March 15, 2016 BACKGROUND: Female sex is associated with poorer outcomes after surgical aortic valve replacement (SAVR). Data on sex-specific differences after transcatheter aortic valve replacement (TAVR) are conflicting. OBJECTIVE: To examine sex-specific differences i ... Full text Link to item Cite

Initial Experience With Commercial Transcatheter Mitral Valve Repair in the United States.

Journal article J Am Coll Cardiol · March 15, 2016 BACKGROUND: Transcatheter mitral valve (MV) repair with the MitraClip received approval in 2013 for the treatment of prohibitive-risk patients with primary mitral regurgitation (MR). OBJECTIVES: The aim of this study was to report the initial U.S. commerci ... Full text Link to item Cite

Implementing a Continuous Quality Improvement Program in a High-Volume Clinical Echocardiography Laboratory: Improving Care for Patients With Aortic Stenosis.

Journal article Circ Cardiovasc Imaging · March 2016 BACKGROUND: The management of aortic stenosis rests on accurate echocardiographic diagnosis. Hence, it was chosen as a test case to examine the utility of continuous quality improvement (CQI) approaches to increase echocardiographic data accuracy and relia ... Full text Open Access Link to item Cite

Diagnostic Strategies for the Evaluation of Chest Pain: Clinical Implications From SCOT-HEART and PROMISE.

Journal article J Am Coll Cardiol · February 23, 2016 SCOT-HEART (Scottish COmputed Tomography of the HEART) and PROMISE (PROspective Multicenter Imaging Study for Evaluation of chest pain) represent the 2 largest and most comprehensive cardiovascular imaging outcome trials in patients with stable chest pain ... Full text Link to item Cite

Work Activities and Compensation of Male and Female Cardiologists.

Journal article J Am Coll Cardiol · February 9, 2016 BACKGROUND: Much remains unknown about experiences, including working activities and pay, of women in cardiology, which is a predominantly male specialty. OBJECTIVES: The goal of this study was to describe the working activities and pay of female cardiolog ... Full text Link to item Cite

Clinical Characteristics and Outcomes of Patients With Myocardial Infarction and Cardiogenic Shock Undergoing Coronary Artery Bypass Surgery: Data From The Society of Thoracic Surgeons National Database.

Journal article Ann Thorac Surg · February 2016 BACKGROUND: Acute myocardial infarction complicated by cardiogenic shock (AMI-CS) is associated with substantial mortality. We evaluated outcomes of patients in The Society of Thoracic Surgeons Adult Cardiac Surgery Database who underwent coronary artery b ... Full text Link to item Cite

Practice gaps in the care of mitral valve regurgitation: Insights from the American College of Cardiology mitral regurgitation gap analysis and advisory panel.

Journal article Am Heart J · February 2016 BACKGROUND: The revised 2014 American College of Cardiology (ACC)/American Heart Association valvular heart disease guidelines provide evidenced-based recommendations for the management of mitral regurgitation (MR). However, knowledge gaps related to our e ... Full text Link to item Cite

Annual Outcomes With Transcatheter Valve Therapy: From the STS/ACC TVT Registry.

Journal article Ann Thorac Surg · February 2016 BACKGROUND: The Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapy (TVT) Registry has been a joint initiative of the STS and the ACC in concert with multiple stakeholders. The TVT Registry has important info ... Full text Link to item Cite

Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation.

Journal article N Engl J Med · January 28, 2016 BACKGROUND: In a randomized trial comparing mitral-valve repair with mitral-valve replacement in patients with severe ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index (LVESVI), survival, or ... Full text Link to item Cite

Safety and clinical effectiveness of drug-eluting stents for saphenous vein graft intervention in older individuals: Results from the medicare-linked National Cardiovascular Data Registry(®) CathPCI Registry(®) (2005-2009).

Journal article Catheter Cardiovasc Interv · January 1, 2016 OBJECTIVES: To evaluate the safety of drug-eluting stents (DES) when treating patients with failing saphenous vein grafts (SVG). BACKGROUND: DES reduce target vessel revascularization in patients with failing SVGs; however, compared with bare metal stents ... Full text Link to item Cite

Appropriate Use of Cardiac Stress Testing with Imaging: A Systematic Review and Meta-Analysis.

Journal article PLoS One · 2016 BACKGROUND: Appropriate use criteria (AUC) for cardiac stress tests address concerns about utilization growth and patient safety. We systematically reviewed studies of appropriateness, including within physician specialties; evaluated trends over time and ... Full text Link to item Cite

Annual Outcomes With Transcatheter Valve Therapy: From the STS/ACC TVT Registry.

Journal article J Am Coll Cardiol · December 29, 2015 BACKGROUND: The Society of Thoracic Surgeons (STS)/American College of Cardiology (ACC) Transcatheter Valve Therapy (TVT) Registry has been a joint initiative of the STS and the ACC in concert with multiple stakeholders. The TVT Registry has important info ... Full text Link to item Cite

Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFR(CT): outcome and resource impacts study.

Journal article Eur Heart J · December 14, 2015 AIMS: In symptomatic patients with suspected coronary artery disease (CAD), computed tomographic angiography (CTA) improves patient selection for invasive coronary angiography (ICA) compared with functional testing. The impact of measuring fractional flow ... Full text Link to item Cite

Evaluation of The Society of Thoracic Surgeons Online Risk Calculator for Assessment of Risk in Patients Presenting for Aortic Valve Replacement After Prior Coronary Artery Bypass Graft: An Analysis Using the STS Adult Cardiac Surgery Database.

Journal article Ann Thorac Surg · December 2015 BACKGROUND: Accurate risk assessment in patients presenting for aortic valve replacement (AVR) after prior coronary artery bypass grafting (CABG) is essential for appropriate selection of surgical versus percutaneous therapy. METHODS: We included 6,534 pat ... Full text Link to item Cite

Quality-of-Life and Economic Outcomes of Assessing Fractional Flow Reserve With Computed Tomography Angiography: PLATFORM.

Journal article J Am Coll Cardiol · December 1, 2015 BACKGROUND: Fractional flow reserve estimated using computed tomography (FFRCT) might improve evaluation of patients with chest pain. OBJECTIVES: The authors sought to determine the effect on cost and quality of life (QOL) of using FFRCT instead of usual c ... Full text Link to item Cite

Outcomes of Patients With Severe Chronic Lung Disease Who Are Undergoing Transcatheter Aortic Valve Replacement.

Journal article Ann Thorac Surg · December 2015 BACKGROUND: In this study, we sought to determine the clinical outcomes after transcatheter aortic valve replacement (TAVR) among patients with chronic lung disease (CLD) and to evaluate the safety of transaortic versus transapical alternate access approac ... Full text Link to item Cite

Introduction to the STS National Database Series: Outcomes Analysis, Quality Improvement, and Patient Safety.

Journal article Ann Thorac Surg · December 2015 The Society of Thoracic Surgeons (STS) National Database is the foundation for most of the Society's quality, research, and patient safety activities. Beginning in January 2016 and repeating each year, The Annals of Thoracic Surgery will publish a monthly ... Full text Link to item Cite

Benefits of a novel percutaneous ventricular assist device for right heart failure: The prospective RECOVER RIGHT study of the Impella RP device.

Journal article J Heart Lung Transplant · December 2015 BACKGROUND: Right ventricular failure (RVF) increases morbidity and mortality. The RECOVER RIGHT study evaluated the safety and efficacy of a novel percutaneous right ventricular assist device, the Impella RP (Abiomed, Danvers, MA), in a prospective, multi ... Full text Link to item Cite

Transapical and Transaortic Transcatheter Aortic Valve Replacement in the United States.

Journal article Ann Thorac Surg · November 2015 BACKGROUND: When transcatheter aortic valve replacement (TAVR) cannot be carried out through transfemoral access, alternative access TAVR is indicated. The purpose of this study was to explore inhospital and 1-year outcomes of patients undergoing alternati ... Full text Link to item Cite

A randomized, double-blind, placebo-controlled trial to evaluate the safety and effectiveness of intracoronary application of a novel bioabsorbable cardiac matrix for the prevention of ventricular remodeling after large ST-segment elevation myocardial infarction: Rationale and design of the PRESERVATION I trial.

Journal article Am Heart J · November 2015 Postinfarction left ventricular (LV) remodeling can result in chronic heart failure and functional impairment. Although pharmacological strategies for established heart failure can be beneficial, preventing remodeling remains a challenge. Injectable bioabs ... Full text Link to item Cite

Risk stratification in patients with pulmonary hypertension undergoing transcatheter aortic valve replacement.

Journal article Heart · October 2015 OBJECTIVE: Pulmonary hypertension (PH) is associated with increased mortality after surgical or transcatheter aortic valve replacement (TAVR) for aortic stenosis (AS), and when the pulmonary artery pressure is particularly elevated, there may be questions ... Full text Link to item Cite

Chronic pacing and adverse outcomes after transcatheter aortic valve implantation.

Journal article Heart · October 2015 OBJECTIVE: Many patients undergoing transcatheter aortic valve implantation (TAVI) have a pre-existing, permanent pacemaker (PPM) or receive one as a consequence of the procedure. We hypothesised that chronic pacing may have adverse effects on TAVI outcome ... Full text Link to item Cite

Contemporary Outcomes of Repeat Aortic Valve Replacement: A Benchmark for Transcatheter Valve-in-Valve Procedures.

Journal article Ann Thorac Surg · October 2015 BACKGROUND: Reoperative aortic valve replacement (re-AVR) after previous AVR is a complex procedure involving redo sternotomy and removal of a previous prosthesis. With increasing use of valve-in-valve transcatheter aortic valve replacement for failed aort ... Full text Link to item Cite

Discussion.

Journal article J Thorac Cardiovasc Surg · October 2015 Full text Link to item Cite

Discussion

Journal article The Journal of Thoracic and Cardiovascular Surgery · October 2015 Full text Cite

Pediatric Appropriate Use Criteria Implementation Project: A Multicenter Outpatient Echocardiography Quality Initiative.

Journal article J Am Coll Cardiol · September 8, 2015 BACKGROUND: Recently published appropriate use criteria (AUC) for initial pediatric outpatient transthoracic echocardiography (TTE) have not yet been evaluated for clinical applicability. OBJECTIVES: This study sought to determine the appropriateness of TT ... Full text Link to item Cite

High-risk percutaneous coronary intervention is associated with reverse left ventricular remodeling and improved outcomes in patients with coronary artery disease and reduced ejection fraction.

Journal article Am Heart J · September 2015 BACKGROUND: Therapies that reverse pathologic left ventricular (LV) remodeling are often associated with improved outcomes. The incidence and impact of reverse LV remodeling after high-risk percutaneous coronary intervention (PCI) are unknown. METHODS: The ... Full text Link to item Cite

Use of outcome measures in pulmonary hypertension clinical trials.

Journal article Am Heart J · September 2015 OBJECTIVES: To evaluate the use of surrogate measures in pulmonary hypertension (PH) clinical trials and how it relates to clinical practice. BACKGROUND: Studies of pulmonary arterial hypertension (PAH) employ a variety of surrogate measures in addition to ... Full text Link to item Cite

Rationale and design of the Prospective LongitudinAl Trial of FFRCT: Outcome and Resource IMpacts study.

Journal article Am Heart J · September 2015 BACKGROUND: Fractional flow reserve (FFR) measured by coronary computed tomography angiography (FFRCT) has been validated against invasive FFR. However, there are no data on how the use of FFRCT affects patient care and outcomes. The aim of this study is t ... Full text Link to item Cite

Quality Improvement Implementation: Improving Reproducibility in the Echocardiography Laboratory.

Journal article J Am Soc Echocardiogr · August 2015 BACKGROUND: Interpretative variability can adversely affect echocardiographic reliability, but there is no widely accepted method to minimize variability and improve reproducibility. METHODS: A continuous quality improvement process was devised that involv ... Full text Link to item Cite

A Summary of the American Society of Echocardiography Foundation Value-Based Healthcare: Summit 2014: The Role of Cardiovascular Ultrasound in the New Paradigm.

Journal article J Am Soc Echocardiogr · July 2015 Value-Based Healthcare: Summit 2014 clearly achieved the three goals set forth at the beginning of this document. First, the live event informed and educated attendees through a discussion of the evolving value-based healthcare environment, including a col ... Full text Link to item Cite

Cardiovascular Health of Patients With Cancer and Cancer Survivors: A Roadmap to the Next Level.

Journal article J Am Coll Cardiol · June 30, 2015 Many existing and emerging cancer therapies have a significant effect on the cardiovascular health of patients with cancer and cancer survivors. This paper examines current aspects of interdisciplinary cardio-oncology clinical care delivery and education i ... Full text Link to item Cite

5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial.

Journal article Lancet · June 20, 2015 BACKGROUND: The Placement of Aortic Transcatheter Valves (PARTNER) trial showed that mortality at 1 year, 2 years, and 3 years is much the same with transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR) for high-risk pat ... Full text Link to item Cite

5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial.

Journal article Lancet · June 20, 2015 BACKGROUND: Based on the early results of the Placement of Aortic Transcatheter Valves (PARTNER) trial, transcatheter aortic valve replacement (TAVR) is an accepted treatment for patients with severe aortic stenosis who are not suitable for surgery. Howeve ... Full text Link to item Cite

Propensity-matched comparisons of clinical outcomes after transapical or transfemoral transcatheter aortic valve replacement: a placement of aortic transcatheter valves (PARTNER)-I trial substudy.

Journal article Circulation · June 2, 2015 BACKGROUND: The higher risk of adverse outcomes after transapical (TA) versus transfemoral (TF) transcatheter aortic valve replacement (TAVR) could be attributable to TA-TAVR being an open surgical procedure or to clinical differences between TA- and TF-TA ... Full text Link to item Cite

Impact of Cardiac Cath Lab Organization on Process and Outcome Quality: A Case Study

Journal article CESR-Schaeffer Working Paper · June 2015 Cite

Prognostic value of serial B-type natriuretic peptide measurement in transcatheter aortic valve replacement (from the PARTNER Trial).

Journal article Am J Cardiol · May 1, 2015 B-type natriuretic peptide (BNP) levels have shown a correlation with outcomes in studies of aortic valve surgery. Results from multicenter trials of BNP in transcatheter aortic valve surgery (TAVR) are lacking. The aim of this study was to investigate the ... Full text Link to item Cite

Midlife Cardiorespiratory Fitness, Incident Cancer, and Survival After Cancer in Men: The Cooper Center Longitudinal Study.

Journal article JAMA Oncol · May 2015 IMPORTANCE: Cardiorespiratory fitness (CRF) as assessed by formalized incremental exercise testing is an independent predictor of numerous chronic diseases, but its association with incident cancer or survival following a diagnosis of cancer has received l ... Full text Link to item Cite

Outcomes of anatomical versus functional testing for coronary artery disease.

Journal article N Engl J Med · April 2, 2015 BACKGROUND: Many patients have symptoms suggestive of coronary artery disease (CAD) and are often evaluated with the use of diagnostic testing, although there are limited data from randomized trials to guide care. METHODS: We randomly assigned 10,003 sympt ... Full text Link to item Cite

Candida infective endocarditis: an observational cohort study with a focus on therapy.

Journal article Antimicrob Agents Chemother · April 2015 Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and u ... Full text Link to item Cite

Strategic transformation of population studies: recommendations of the working group on epidemiology and population sciences from the National Heart, Lung, and Blood Advisory Council and Board of External Experts.

Journal article Am J Epidemiol · March 15, 2015 In 2013, the National Heart, Lung, and Blood Institute assembled a working group on epidemiology and population sciences from its Advisory Council and Board of External Experts. The working group was charged with making recommendations to the National Hear ... Full text Link to item Cite

Predicting recurrent mitral regurgitation after mitral valve repair for severe ischemic mitral regurgitation.

Journal article J Thorac Cardiovasc Surg · March 2015 OBJECTIVES: The Cardiothoracic Surgical Trials Network recently reported no difference in the primary end point of left ventricular end-systolic volume index at 1 year postsurgery in patients randomized to repair (n = 126) or replacement (n = 125) for seve ... Full text Link to item Cite

Transcatheter aortic valve replacement and standard therapy in inoperable patients with aortic stenosis and low EF.

Journal article Heart · March 2015 OBJECTIVES: The aims of this study were to evaluate the effect of left ventricular (LV) dysfunction on clinical outcomes after transcatheter aortic valve replacement (TAVR) and standard therapy for severe aortic stenosis (AS) and to assess LV ejection frac ... Full text Link to item Cite

Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study.

Journal article Clin Infect Dis · March 1, 2015 BACKGROUND: The impact of early valve surgery (EVS) on the outcome of Staphylococcus aureus (SA) prosthetic valve infective endocarditis (PVIE) is unresolved. The objective of this study was to evaluate the association between EVS, performed within the fir ... Full text Link to item Cite

Three-year outcomes associated with embolic protection in saphenous vein graft intervention: results in 49 325 senior patients in the Medicare-linked National Cardiovascular Data Registry CathPCI Registry.

Journal article Circ Cardiovasc Interv · March 2015 BACKGROUND: Information is limited on contemporary use and outcomes of embolic protection devices (EPDs) in saphenous vein graft interventions. METHODS AND RESULTS: We formed a longitudinal cohort (2005-2009; n=49 325) by linking National Cardiovascular Da ... Full text Link to item Cite

Echocardiographic imaging of procedural complications during balloon-expandable transcatheter aortic valve replacement.

Journal article JACC Cardiovasc Imaging · March 2015 Transcatheter aortic valve replacement (TAVR) using a balloon-expandable valve is an accepted alternative to surgical replacement for severe, symptomatic aortic stenosis in high risk or inoperable patients. Intraprocedural transesophageal echocardiography ... Full text Link to item Cite

Paravalvular regurgitation after transcatheter aortic valve replacement with the Edwards sapien valve in the PARTNER trial: characterizing patients and impact on outcomes.

Journal article Eur Heart J · February 14, 2015 AIM: The impact of paravalvular regurgitation (PVR) following transcatheter aortic valve replacement (TAVR) remains uncertain. In this analysis, we sought to evaluate the impact of varying degrees of PVR on both mortality and changes in ventricular geometr ... Full text Link to item Cite

Hemodynamic outcomes of transcatheter aortic valve replacement and medical management in severe, inoperable aortic stenosis: a longitudinal echocardiographic study of cohort B of the PARTNER trial.

Journal article J Am Soc Echocardiogr · February 2015 BACKGROUND: Inoperable aortic stenosis may be treated with either transcatheter aortic valve replacement (TAVR) or medical management (MM) with or without balloon aortic valvuloplasty (BAV). The aim of this study was to compare the long-term echocardiograp ... Full text Link to item Cite

Outcomes of inoperable symptomatic aortic stenosis patients not undergoing aortic valve replacement: insight into the impact of balloon aortic valvuloplasty from the PARTNER trial (Placement of AoRtic TraNscathetER Valve trial).

Journal article JACC Cardiovasc Interv · February 2015 OBJECTIVES: The aim of this report is to characterize the impact of balloon aortic valvuloplasty (BAV) in patients not undergoing aortic valve replacement in the PARTNER (Placement of AoRtic TraNscathetER Valves) trial. BACKGROUND: The PARTNER trial is the ... Full text Link to item Cite

One-year outcome following biological or mechanical valve replacement for infective endocarditis.

Journal article Int J Cardiol · January 15, 2015 BACKGROUND: Nearly half of patients require cardiac surgery during the acute phase of infective endocarditis (IE). We describe the characteristics of patients according to the type of valve replacement (mechanical or biological), and examine whether the ty ... Full text Link to item Cite

Association between surgical indications, operative risk, and clinical outcome in infective endocarditis: a prospective study from the International Collaboration on Endocarditis.

Journal article Circulation · January 13, 2015 BACKGROUND: Use of surgery for the treatment of infective endocarditis (IE) as related to surgical indications and operative risk for mortality has not been well defined. METHODS AND RESULTS: The International Collaboration on Endocarditis-PLUS (ICE-PLUS) ... Full text Link to item Cite

Costs associated with health care-associated infections in cardiac surgery.

Journal article J Am Coll Cardiol · January 6, 2015 BACKGROUND: Health care-associated infections (HAIs) are the most common noncardiac complications after cardiac surgery and are associated with increased morbidity and mortality. Current information about their economic burden is limited. OBJECTIVES: This ... Full text Link to item Cite

Contemporary real-world outcomes of surgical aortic valve replacement in 141,905 low-risk, intermediate-risk, and high-risk patients.

Journal article Ann Thorac Surg · January 2015 BACKGROUND: The introduction of transcatheter aortic valve replacement mandates attention to outcomes after surgical aortic valve replacement (SAVR) in low-risk, intermediate-risk, and very high-risk patients. METHODS: The study population included 141,905 ... Full text Link to item Cite

Predictors and clinical outcomes of permanent pacemaker implantation after transcatheter aortic valve replacement: the PARTNER (Placement of AoRtic TraNscathetER Valves) trial and registry.

Journal article JACC Cardiovasc Interv · January 2015 OBJECTIVES: The purpose of this study was to identify predictors and clinical implications of permanent pacemaker (PPM) implantation after transcatheter aortic valve replacement (TAVR). BACKGROUND: Cardiac conduction disturbances requiring PPM are a freque ... Full text Link to item Cite

The PROMISE trial: An inside perspective.

Journal article J Cardiovasc Comput Tomogr · 2015 Full text Link to item Cite

Surgical treatment of moderate ischemic mitral regurgitation.

Journal article N Engl J Med · December 4, 2014 BACKGROUND: Ischemic mitral regurgitation is associated with increased mortality and morbidity. For surgical patients with moderate regurgitation, the benefits of adding mitral-valve repair to coronary-artery bypass grafting (CABG) are uncertain. METHODS: ... Full text Link to item Cite

Implications of the 2013 ACC/AHA cholesterol guidelines for adults in contemporary cardiovascular practice: insights from the NCDR PINNACLE registry.

Journal article J Am Coll Cardiol · December 2, 2014 BACKGROUND: In a significant update, the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines recommend fixed-dose statin therapy for those at risk and do not recommend nonstatin therapies or treatment to target l ... Full text Link to item Cite

Periprocedural imaging and outcomes after catheter ablation of atrial fibrillation.

Journal article Heart · December 2014 OBJECTIVE: Catheter ablation of atrial fibrillation (AF) has become an increasingly safe and effective therapy. This has been partly attributed to the use of adjunctive imaging modalities. We aimed to describe the use and associated outcomes of periprocedu ... Full text Link to item Cite

Costs of periprocedural complications in patients treated with transcatheter aortic valve replacement: results from the Placement of Aortic Transcatheter Valve trial.

Journal article Circ Cardiovasc Interv · December 2014 BACKGROUND: In patients with severe aortic stenosis, transcatheter aortic valve replacement (TAVR) improves survival when compared with nonsurgical therapy but with higher in-hospital and lifetime costs. Complications associated with TAVR may decrease with ... Full text Link to item Cite

The association of chronic lung disease with early mortality and respiratory adverse events after aortic valve replacement.

Journal article Ann Thorac Surg · December 2014 BACKGROUND: We studied the association between components of chronic lung disease (CLD) assessment and operative outcomes in patients undergoing aortic valve replacement (AVR) for aortic stenosis. METHODS: From 2011 to 2012, 9,177 patients included in The ... Full text Link to item Cite

The association of transcatheter aortic valve replacement availability and hospital aortic valve replacement volume and mortality in the United States.

Journal article Ann Thorac Surg · December 2014 BACKGROUND: Whether the introduction of transcatheter aortic valve replacement (TAVR) has affected hospitals' surgical aortic valve replacement (SAVR) and overall aortic valve replacement (AVR) case volumes and outcomes in the United States is unknown. MET ... Full text Link to item Cite

Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial.

Journal article JAMA · November 19, 2014 IMPORTANCE: While effective in preventing stroke in patients with atrial fibrillation (AF), warfarin is limited by a narrow therapeutic profile, a need for lifelong coagulation monitoring, and multiple drug and diet interactions. OBJECTIVE: To determine wh ... Full text Link to item Cite

Exercise and risk of major cardiovascular events in adult survivors of childhood hodgkin lymphoma: a report from the childhood cancer survivor study.

Journal article J Clin Oncol · November 10, 2014 PURPOSE: Survivors of Hodgkin lymphoma (HL) are at increased risk of treatment-related cardiovascular (CV) events; whether exercise modifies this risk is unknown. METHODS: Survivors of HL (n = 1,187; median age, 31.2 years) completed a questionnaire evalua ... Full text Link to item Cite

An innovator ahead of her time.

Journal article J Am Coll Cardiol · October 7, 2014 Full text Link to item Cite

Physician decision making and trends in the use of cardiac stress testing in the United States: an analysis of repeated cross-sectional data.

Journal article Ann Intern Med · October 7, 2014 BACKGROUND: Cardiac stress testing, particularly with imaging, has been the focus of debates about rising health care costs, inappropriate use, and patient safety in the context of radiation exposure. OBJECTIVE: To determine whether U.S. trends in cardiac ... Full text Link to item Cite

Impact of aortic annulus size on valve hemodynamics and clinical outcomes after transcatheter and surgical aortic valve replacement: insights from the PARTNER Trial.

Journal article Circ Cardiovasc Interv · October 2014 BACKGROUND: The objective was to evaluate the effects of aortic annulus size on valve hemodynamics and clinical outcomes in those patients included in the Placement of Aortic Transcatheter Valves (PARTNER) randomized controlled trial cohort A and the nonra ... Full text Link to item Cite

Incidence and sequelae of prosthesis-patient mismatch in transcatheter versus surgical valve replacement in high-risk patients with severe aortic stenosis: a PARTNER trial cohort--a analysis.

Journal article J Am Coll Cardiol · September 30, 2014 BACKGROUND: Little is known about the incidence of prosthesis-patient mismatch (PPM) and its impact on outcomes after transcatheter aortic valve replacement (TAVR). OBJECTIVES: The objectives of this study were: 1) to compare the incidence of PPM in the TA ... Full text Link to item Cite

2013 American College of Cardiology/American Heart Association and 2004 Adult Treatment Panel III cholesterol guidelines applied to HIV-infected patients with/without subclinical high-risk coronary plaque.

Journal article AIDS · September 10, 2014 BACKGROUND: The 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines are being applied to HIV-infected patients but have not been validated in this at-risk population, which is known to have a high prevalence of s ... Full text Link to item Cite

Practice patterns and clinical outcomes after hybrid coronary revascularization in the United States: an analysis from the society of thoracic surgeons adult cardiac database.

Journal article Circulation · September 9, 2014 BACKGROUND: Hybrid coronary revascularization (HCR) involves a combination of surgical and percutaneous techniques, which in selected patients may present an alternative to conventional coronary artery bypass grafting (CABG). METHODS AND RESULTS: Patients ... Full text Link to item Cite

Comparison of the use of hemodynamic support in patients ≥80 years versus patients <80 years during high-risk percutaneous coronary interventions (from the Multicenter PROTECT II Randomized Study).

Journal article Am J Cardiol · September 1, 2014 The outcomes of hemodynamic support during high-risk percutaneous coronary intervention in the very elderly are unknown. We sought to compare outcomes between the patients ≥80 years versus patients <80 years enrolled in the PROTECT II (Prospective Randomiz ... Full text Link to item Cite

Pre-exercise participation cardiovascular screening in a heterogeneous cohort of adult cancer patients.

Journal article Oncologist · September 2014 BACKGROUND: The purpose of this study was to investigate the extent of pre-exercise participation ("preparticipation") health screening in a heterogeneous cohort of adult cancer patients. METHODS: Patients (n = 413) with histologically confirmed solid or h ... Full text Link to item Cite

Examination of the treatment selection process in a multicenter observational study.

Journal article Circ Cardiovasc Qual Outcomes · September 2014 BACKGROUND: Many multicenter clinical trials use permuted-block randomization to create balanced treatment allocations within clinical centers. Unlike randomized trials, observational studies do not control treatment allocation, and statistical models are ... Full text Link to item Cite

Safety and efficacy of aerobic training in patients with cancer who have heart failure: an analysis of the HF-ACTION randomized trial.

Journal article J Clin Oncol · August 10, 2014 PURPOSE: To investigate the efficacy and safety of aerobic training (AT) in patients with cancer with medically stable heart failure (HF). PATIENTS AND METHODS: A retrospective analysis of 90 patients with cancer who have HF and who were randomly assigned ... Full text Link to item Cite

Does mitral valve repair offer an advantage over replacement in patients undergoing aortic valve replacement?

Journal article Ann Thorac Surg · August 2014 BACKGROUND: Concomitant aortic and mitral valve (MV) operations have more than doubled over the past decade. We utilized the Society of Thoracic Surgeons Adult Cardiac Surgery Database (ACSD) to evaluate outcomes for patients undergoing combined aortic val ... Full text Link to item Cite

A critical review of hemodynamic changes and left ventricular remodeling after surgical aortic valve replacement and percutaneous aortic valve replacement.

Journal article Am Heart J · August 2014 UNLABELLED: The introduction of transcatheter aortic valve replacement (TAVR) in clinical practice has widened options for symptomatic patients at high surgical risk; however, it is not known whether TAVR has equivalent or prolonged benefits in terms of le ... Full text Link to item Cite

Cardiovascular imaging utilization: boom or bust?

Journal article JACC Cardiovasc Imaging · July 2014 Full text Link to item Cite

Quantitative assessment of mitral valve coaptation using three-dimensional transesophageal echocardiography.

Journal article Ann Thorac Surg · June 2014 BACKGROUND: Functional mitral regurgitation (FMR) occurs as a consequence of left ventricular remodeling and is an independent predictor of adverse outcome. FMR is assessed qualitatively with two-dimensional echocardiography, but accurate quantitation of t ... Full text Link to item Cite

Prevalence and predictors of nonobstructive coronary artery disease identified with coronary angiography in contemporary clinical practice.

Journal article Am Heart J · June 2014 BACKGROUND: Guidelines recommend noninvasive tests (NITs) to risk stratify and identify patients with higher likelihood of coronary artery disease (CAD) prior to elective coronary angiography. However, a high percentage of patients are found to have nonobs ... Full text Link to item Cite

PROspective Multicenter Imaging Study for Evaluation of chest pain: rationale and design of the PROMISE trial.

Journal article Am Heart J · June 2014 BACKGROUND: Suspected coronary artery disease (CAD) is one of the most common, potentially life-threatening diagnostic problems clinicians encounter. However, no large outcome-based randomized trials have been performed to guide the selection of diagnostic ... Full text Link to item Cite

Comparative definitions for moderate-severe ischemia in stress nuclear, echocardiography, and magnetic resonance imaging.

Journal article JACC Cardiovasc Imaging · June 2014 The lack of standardized reporting of the magnitude of ischemia on noninvasive imaging contributes to variability in translating the severity of ischemia across stress imaging modalities. We identified the risk of coronary artery disease (CAD) death or myo ... Full text Link to item Cite

Early regression of severe left ventricular hypertrophy after transcatheter aortic valve replacement is associated with decreased hospitalizations.

Journal article JACC Cardiovasc Interv · June 2014 OBJECTIVES: This study sought to examine the relationship between left ventricular mass (LVM) regression and clinical outcomes after transcatheter aortic valve replacement (TAVR). BACKGROUND: LVM regression after valve replacement for aortic stenosis is as ... Full text Link to item Cite

Effects of nonlinear aerobic training on erectile dysfunction and cardiovascular function following radical prostatectomy for clinically localized prostate cancer.

Journal article Eur Urol · May 2014 UNLABELLED: Erectile dysfunction (ED) is a major adverse effect of radical prostatectomy (RP). We conducted a randomized controlled trial to examine the efficacy of aerobic training (AT) compared with usual care (UC) on ED prevalence in 50 men (n=25 per gr ... Full text Link to item Cite

The expanding role of mitral valve repair in triple valve operations: contemporary North American outcomes in 8,021 patients.

Journal article Ann Thorac Surg · May 2014 BACKGROUND: Although the operative risk of multivalve operations has historically been high, current outcomes are poorly understood. We sought to evaluate factors influencing contemporary results of triple-valve operations using The Society of Thoracic Sur ... Full text Link to item Cite

Cost effectiveness of a gene expression score and myocardial perfusion imaging for diagnosis of coronary artery disease.

Journal article Am Heart J · May 2014 BACKGROUND: Over 3 million patients annually present with symptoms suggestive of obstructive coronary artery disease (oCAD) in the United States (US), but a cardiac etiology is found in as few as 10% of cases. Usual care may include advanced cardiac testin ... Full text Link to item Cite

Sex-related differences in outcomes after transcatheter or surgical aortic valve replacement in patients with severe aortic stenosis: Insights from the PARTNER Trial (Placement of Aortic Transcatheter Valve).

Journal article J Am Coll Cardiol · April 22, 2014 OBJECTIVES: This study sought to examine sex-specific differences in outcomes after surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR) in high-risk patients with severe aortic stenosis. BACKGROUND: The PARTNER (Placem ... Full text Link to item Cite

Sample size requirements for estimating effective dose from computed tomography using solid-state metal-oxide-semiconductor field-effect transistor dosimetry.

Journal article Med Phys · April 2014 PURPOSE: Effective dose (ED) is a widely used metric for comparing ionizing radiation burden between different imaging modalities, scanners, and scan protocols. In computed tomography (CT), ED can be estimated by performing scans on an anthropomorphic phan ... Full text Link to item Cite

Sex-based differences in outcomes after percutaneous coronary intervention for acute myocardial infarction: a report from TRANSLATE-ACS.

Journal article J Am Heart Assoc · February 7, 2014 BACKGROUND: Data regarding sex-based outcomes after percutaneous coronary intervention (PCI) for myocardial infarction are mixed. We sought to examine whether sex differences in outcomes exist in contemporary practice. METHODS AND RESULTS: We examined acut ... Full text Open Access Link to item Cite

ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons.

Journal article J Am Coll Cardiol · February 4, 2014 The American College of Cardiology Foundation along with key specialty and subspecialty societies, conducted an appropriate use review of common clinical presentations for stable ischemic heart disease (SIHD) to consider use of stress testing and anatomic ... Full text Link to item Cite

Utility of 3-dimensional echocardiography, global longitudinal strain, and exercise stress echocardiography to detect cardiac dysfunction in breast cancer patients treated with doxorubicin-containing adjuvant therapy.

Journal article Breast Cancer Res Treat · February 2014 Conventional resting left ventricular ejection fraction (LVEF) assessments have limitations for detecting doxorubicin (DOX)-related cardiac dysfunction. Novel resting echocardiographic parameters, including 3-dimensional echocardiography (3DE) and global l ... Full text Link to item Cite

ACCF/AHA/ASE/ASNC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2013 multimodality appropriate use criteria for the detection and risk assessment of stable ischemic heart disease: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons.

Journal article J Nucl Cardiol · February 2014 The American College of Cardiology Foundation along with key specialty and subspecialty societies, conducted an appropriate use review of common clinical presentations for stable ischemic heart disease (SIHD) to consider use of stress testing and anatomic ... Full text Link to item Cite

Comparative effectiveness of drug-eluting stents on long-term outcomes in elderly patients treated for in-stent restenosis: a report from the National Cardiovascular Data Registry.

Journal article Catheter Cardiovasc Interv · February 2014 OBJECTIVE: We assessed the long-term outcomes of elderly patients who had in-stent restenosis (ISR) treated with drug-eluting stents (DES) compared with other treatment strategies. BACKGROUND: Elderly patients with ISR represent a vulnerable group of which ... Full text Link to item Cite

Registry: Using data to survive in the new world

Journal article Journal of Nuclear Cardiology · January 1, 2014 Cite

Safety and efficacy of aerobic training in operable breast cancer patients receiving neoadjuvant chemotherapy: a phase II randomized trial.

Journal article Acta Oncol · January 2014 BACKGROUND: To evaluate the safety and efficacy of moderate-to-high intensity aerobic training in breast cancer patients receiving neoadjuvant chemotherapy. METHODS: Twenty patients with stage IIB-IIIC operable breast cancer were randomly assigned to recei ... Full text Link to item Cite

Impact of preoperative moderate/severe mitral regurgitation on 2-year outcome after transcatheter and surgical aortic valve replacement: insight from the Placement of Aortic Transcatheter Valve (PARTNER) Trial Cohort A.

Journal article Circulation · December 24, 2013 BACKGROUND: The effect of preoperative mitral regurgitation (MR) on clinical outcomes of patients undergoing transcatheter aortic valve replacement (TAVR) is controversial. This study sought to examine the impact of moderate and severe MR on outcomes after ... Full text Link to item Cite

Clinical implications of referral bias in the diagnostic performance of exercise testing for coronary artery disease.

Journal article J Am Heart Assoc · December 13, 2013 BACKGROUND: Exercise testing with echocardiography or myocardial perfusion imaging is widely used to risk-stratify patients with suspected coronary artery disease. However, reports of diagnostic performance rarely adjust for referral bias, and this practic ... Full text Link to item Cite

Outcomes of transcatheter and surgical aortic valve replacement in high-risk patients with aortic stenosis and left ventricular dysfunction: results from the Placement of Aortic Transcatheter Valves (PARTNER) trial (cohort A).

Journal article Circ Cardiovasc Interv · December 2013 BACKGROUND: The Placement of Aortic Transcatheter Valves (PARTNER) trial demonstrated similar survival after transcatheter and surgical aortic valve replacement (TAVR and SAVR, respectively) in high-risk patients with symptomatic, severe aortic stenosis. T ... Full text Link to item Cite

Edoxaban versus warfarin in patients with atrial fibrillation.

Journal article N Engl J Med · November 28, 2013 BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, dou ... Full text Link to item Cite

Isolated mitral valve surgery risk in 77,836 patients from the Society of Thoracic Surgeons database.

Journal article Ann Thorac Surg · November 2013 BACKGROUND: Understanding the operative outcomes of mitral valve (MV) surgery across the spectrum of predicted risk of mortality (PROM) is necessary to determine the best use of novel percutaneous approaches. METHODS: The Society of Thoracic Surgeons Adult ... Full text Link to item Cite

Impact of choice of imaging modality accompanying outpatient exercise stress testing on outcomes and resource use after revascularization for acute coronary syndromes.

Journal article Am Heart J · October 2013 BACKGROUND: Exercise stress testing is commonly obtained after percutaneous coronary intervention (PCI) performed for acute coronary syndromes (ACS). We compared the relationships between exercise echocardiography and nuclear testing after ACS-related PCI ... Full text Link to item Cite

Associations between valve repair and reduced operative mortality in 21,056 mitral/tricuspid double valve procedures.

Journal article Eur J Cardiothorac Surg · September 2013 OBJECTIVES: Repair of either the mitral (M) or tricuspid (T) valve in single valve surgery is associated with reduced operative mortality. It is unclear, however, how valve repair influences mortality in combined MT procedures. This topic was evaluated in ... Full text Link to item Cite

Modulation of circulating angiogenic factors and tumor biology by aerobic training in breast cancer patients receiving neoadjuvant chemotherapy.

Journal article Cancer Prev Res (Phila) · September 2013 Aerobic exercise training (AET) is an effective adjunct therapy to attenuate the adverse side-effects of adjuvant chemotherapy in women with early breast cancer. Whether AET interacts with the antitumor efficacy of chemotherapy has received scant attention ... Full text Link to item Cite

Use of the Corus® CAD Gene Expression Test for Assessment of Obstructive Coronary Artery Disease Likelihood in Symptomatic Non-Diabetic Patients.

Journal article PLoS Curr · August 26, 2013 The determination of the underlying etiology of symptoms suggestive of obstructive coronary artery disease (CAD, ≥50% stenosis in a major coronary artery) is a common clinical challenge in both primary care and cardiology clinics. Usual care in low to medi ... Full text Link to item Cite

Preventing Cardiovascular Complications of Breast Cancer Treatment: The Utility of Effective Exercise Prescription

Journal article Current Cardiovascular Risk Reports · August 1, 2013 Advances in early detection and adjuvant therapy have led to dramatic improvements in longevity following a cancer diagnosis. As a result, approximately 3 million breast cancer survivors are alive in the US, with this figure projected to increase to 3.7 mi ... Full text Cite

Registry.

Journal article J Nucl Cardiol · August 2013 Full text Link to item Cite

Use of stress testing and diagnostic catheterization after coronary stenting: association of site-level patterns with patient characteristics and outcomes in 247,052 Medicare beneficiaries.

Journal article J Am Coll Cardiol · July 30, 2013 OBJECTIVES: The aim of this study was to determine diagnostic testing patterns after percutaneous coronary intervention (PCI). BACKGROUND: Little is known about patterns of diagnostic testing after PCI in the United States or the relationship of these patt ... Full text Link to item Cite

Determinants and outcomes of acute transcatheter valve-in-valve therapy or embolization: a study of multiple valve implants in the U.S. PARTNER trial (Placement of AoRTic TraNscathetER Valve Trial Edwards SAPIEN Transcatheter Heart Valve).

Journal article J Am Coll Cardiol · July 30, 2013 OBJECTIVES: This study investigated the determinants and outcomes of acute insertion of a second transcatheter prosthetic valve (TV) within the first (TV-in-TV) or transcatheter valve embolization (TVE) after transcatheter aortic valve replacement (TAVR). ... Full text Link to item Cite

Comparison of transcatheter and surgical aortic valve replacement in severe aortic stenosis: a longitudinal study of echocardiography parameters in cohort A of the PARTNER trial (placement of aortic transcatheter valves).

Journal article J Am Coll Cardiol · June 25, 2013 OBJECTIVES: This study sought to compare echocardiographic findings in patients with critical aortic stenosis following surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR). BACKGROUND: The PARTNER (Placement of Aortic ... Full text Link to item Cite

Predictors of mortality and outcomes of therapy in low-flow severe aortic stenosis: a Placement of Aortic Transcatheter Valves (PARTNER) trial analysis.

Journal article Circulation · June 11, 2013 BACKGROUND: The prognosis and treatment of patients with low-flow (LF) severe aortic stenosis are controversial. METHODS AND RESULTS: The Placement of Aortic Transcatheter Valves (PARTNER) trial randomized patients with severe aortic stenosis to medical ma ... Full text Link to item Cite

Variation in warfarin thromboprophylaxis after mitral valve repair: does equipoise exist and is a randomized trial warranted?

Journal article Ann Thorac Surg · June 2013 BACKGROUND: There are limited data available to inform decision making regarding warfarin thromboprophylaxis early after mitral valve repair. METHODS: We studied 13,082 patients from The Society of Thoracic Surgeons Adult Cardiac Surgery Database (STS ACSD ... Full text Link to item Cite

2013 appropriate utilization of cardiovascular imaging: a methodology for the development of joint criteria for the appropriate utilization of cardiovascular imaging by the American College of Cardiology Foundation and American College of Radiology.

Journal article J Am Coll Radiol · June 2013 The American College of Radiology (ACR) and the American College of Cardiology Foundation (ACCF) have jointly developed a method to define appropriate utilization of cardiovascular imaging. The primary role of this method is to create a series of documents ... Full text Link to item Cite

2013 appropriate utilization of cardiovascular imaging: a methodology for the development of joint criteria for the appropriate utilization of cardiovascular imaging by the American College of Cardiology Foundation and American College of Radiology.

Journal article J Am Coll Cardiol · May 28, 2013 The American College of Radiology (ACR) and the American College of Cardiology Foundation (ACCF) have jointly developed a method to define appropriate utilization of cardiovascular imaging. The primary role of this method is to create a series of documents ... Full text Link to item Cite

Treatment of functional mitral valve regurgitation with the permanent percutaneous transvenous mitral annuloplasty system: results of the multicenter international Percutaneous Transvenous Mitral Annuloplasty System to Reduce Mitral Valve Regurgitation in Patients with Heart Failure trial.

Journal article Am Heart J · May 2013 OBJECTIVES: PTOLEMY-2 was a prospective multicenter phase I single-arm feasibility trial to evaluate the second-generation permanent percutaneous transvenous mitral annuloplasty (PTMA) device in reducing functional mitral regurgitation (MR). BACKGROUND: Pe ... Full text Link to item Cite

Long-term safety and effectiveness of mechanical versus biologic aortic valve prostheses in older patients: results from the Society of Thoracic Surgeons Adult Cardiac Surgery National Database.

Journal article Circulation · April 23, 2013 BACKGROUND: There is a paucity of long-term data comparing biological versus mechanical aortic valve prostheses in older individuals. METHODS AND RESULTS: We performed follow-up of patients aged 65 to 80 years undergoing aortic valve replacement with a bio ... Full text Link to item Cite

Effect of race and ethnicity on outcomes with drug-eluting and bare metal stents: results in 423 965 patients in the linked National Cardiovascular Data Registry and centers for Medicare & Medicaid services payer databases.

Journal article Circulation · April 2, 2013 BACKGROUND: Black, Hispanic, and Asian patients have been underrepresented in percutaneous coronary intervention clinical trials; therefore, there are limited data available on outcomes for these race/ethnicity groups. METHODS AND RESULTS: We examined outc ... Full text Link to item Cite

Implementation of echocardiography core laboratory best practices: a case study of the PARTNER I trial.

Journal article J Am Soc Echocardiogr · April 2013 BACKGROUND: Multicenter clinical trials use echocardiographic core laboratories to ensure expertise and consistency in the assessment of imaging eligibility criteria, as well as safety and efficacy end points. The aim of this study was to report the real-w ... Full text Link to item Cite

The influence of adjuvant therapy on cardiorespiratory fitness in early-stage breast cancer seven years after diagnosis: the Cooper Center Longitudinal Study.

Journal article Breast Cancer Res Treat · April 2013 We examined cardiorespiratory fitness (CRF) levels in early stage breast cancer patients and determined whether CRF differs as a function of adjuvant therapy regimen. A total of 180 early breast cancer patients representing three treatment groups (surgery ... Full text Link to item Cite

Exercise therapy as treatment for cardiovascular and oncologic disease after a diagnosis of early-stage cancer.

Journal article Semin Oncol · April 2013 Advances in early detection and adjuvant therapy have led to dramatic improvements in longevity after a cancer diagnosis. As a result, there are ~13.7 million cancer survivors alive in the United States, with this figure projected to increase to 18 million ... Full text Link to item Cite

A blood-based gene expression test for obstructive coronary artery disease tested in symptomatic nondiabetic patients referred for myocardial perfusion imaging the COMPASS study.

Journal article Circ Cardiovasc Genet · April 2013 BACKGROUND- Obstructive coronary artery disease diagnosis in symptomatic patients often involves noninvasive testing before invasive coronary angiography. A blood-based gene expression score (GES) was previously validated in nondiabetic patients referred f ... Full text Link to item Cite

Healthcare reform for imagers: finding a way forward now.

Journal article JACC Cardiovasc Imaging · March 2013 The changing healthcare environment presents many challenges to cardiovascular imagers. This perspective paper uses current trends to propose strategies that cardiovascular imagers can follow to lead in managing change and developing the imaging laboratory ... Full text Link to item Cite

Patterns of stress testing and diagnostic catheterization after coronary stenting in 250 350 medicare beneficiaries.

Journal article Circ Cardiovasc Imaging · January 1, 2013 BACKGROUND: Patterns of noninvasive stress test (ST) and invasive coronary angiography (CA) utilization after percutaneous coronary intervention (PCI) are not well described in older populations. METHODS AND RESULTS: We linked National Cardiovascular Data ... Full text Link to item Cite

Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke.

Journal article Clin Infect Dis · January 2013 BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were ... Full text Link to item Cite

The potential role of aerobic exercise to modulate cardiotoxicity of molecularly targeted cancer therapeutics.

Journal article Oncologist · 2013 Molecularly targeted therapeutics (MTT) are the future of cancer systemic therapy. They have already moved from palliative therapy for advanced solid malignancies into the setting of curative-intent treatment for early-stage disease. Cardiotoxicity is a fr ... Full text Link to item Cite

Analysis of early hypertension and clinical outcome with bevacizumab: results from seven phase III studies.

Journal article Oncologist · 2013 BACKGROUND: Hypertension is associated with antivascular endothelial growth factor treatment, but the clinical implications of hypertension are uncertain. To assess the prognostic and predictive value of bevacizumab-related hypertension, a comprehensive an ... Full text Link to item Cite

HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort.

Journal article PLoS One · 2013 The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics a ... Full text Link to item Cite

Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine.

Journal article Drug Des Devel Ther · 2013 OBJECTIVE: MAP0004 is an investigational product which delivers dihydroergotamine (DHE) through the lung via a breath-synchronized metered dose inhaler. The objective of this study was to compare the acute effects of orally inhaled and intravenous (IV) DHE ... Full text Open Access Link to item Cite

Long-term outcomes of older diabetic patients after percutaneous coronary stenting in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.

Journal article J Am Coll Cardiol · December 4, 2012 OBJECTIVES: The purpose of this study was to characterize long-term outcomes of percutaneous coronary intervention (PCI) in elderly diabetic patients in routine practice. BACKGROUND: Although drug-eluting stent (DES) implantation in diabetic patients is co ... Full text Link to item Cite

Cardiac imaging approaches to evaluate drug-induced myocardial dysfunction.

Journal article Am Heart J · December 2012 The ability to make informed benefit-risk assessments for potentially cardiotoxic new compounds is of considerable interest and importance at the public health, drug development, and individual patient levels. Cardiac imaging approaches in the evaluation o ... Full text Link to item Cite

Appropriate use criteria: past, present, future.

Journal article J Am Soc Echocardiogr · November 2012 Full text Link to item Cite

Evaluating the impact of public health notification: Duke clopidogrel experience.

Journal article Circ Cardiovasc Qual Outcomes · November 2012 BACKGROUND: Provider and public health interventions in the late 2006 sought to change the duration of clopidogrel use after drug-eluting stent (DES) implantation. We evaluated whether public health interventions were associated with changes in patient-rep ... Full text Link to item Cite

Short- and long-term outcomes of coronary stenting in women versus men: results from the National Cardiovascular Data Registry Centers for Medicare & Medicaid services cohort.

Journal article Circulation · October 30, 2012 BACKGROUND: Conflicting evidence exists on sex-based outcomes after coronary stenting. METHODS AND RESULTS: Data on 426 996 patients ≥65 years old (42.3% women) from the National Cardiovascular Data Registry CathPCI Registry (2004-2008) were linked to Medi ... Full text Link to item Cite

A prospective, randomized clinical trial of hemodynamic support with Impella 2.5 versus intra-aortic balloon pump in patients undergoing high-risk percutaneous coronary intervention: the PROTECT II study.

Journal article Circulation · October 2, 2012 BACKGROUND: Although coronary artery bypass grafting is generally preferred in symptomatic patients with severe, complex multivessel, or left main disease, some patients present with clinical features that make coronary artery bypass grafting clinically un ... Full text Link to item Cite

Comparative effectiveness of drug-eluting versus bare-metal stents in elderly patients undergoing revascularization of chronic total coronary occlusions: results from the National Cardiovascular Data Registry, 2005-2008.

Journal article JACC Cardiovasc Interv · October 2012 OBJECTIVES: This study sought to investigate the long-term effectiveness of drug-eluting stents (DES) versus bare-metal stents (BMS). BACKGROUND: Improved recanalization techniques have increased interest in percutaneous coronary intervention (PCI) for chr ... Full text Link to item Cite

Patterns and predictors of stress testing modality after percutaneous coronary stenting: data from the NCDR(®).

Journal article JACC Cardiovasc Imaging · October 2012 OBJECTIVES: We evaluated temporal trends and geographic variation in choice of stress testing modality after percutaneous coronary intervention (PCI), as well as associations between modality and procedure use after testing. BACKGROUND: Stress testing is f ... Full text Link to item Cite

Long-term survival after aortic valve replacement among high-risk elderly patients in the United States: insights from the Society of Thoracic Surgeons Adult Cardiac Surgery Database, 1991 to 2007.

Journal article Circulation · September 25, 2012 BACKGROUND: Surgical aortic valve replacement (AVR) remains the standard of care for the treatment of operable, symptomatic aortic valve disease; however, to date, there are limited national data on the contemporary long-term outcomes after AVR in older in ... Full text Link to item Cite

Downstream testing and subsequent procedures after coronary computed tomographic angiography following coronary stenting in patients ≥65 years of age.

Journal article Am J Cardiol · September 15, 2012 Limited data are available on the use of coronary computed tomographic angiography (CCTA) in patients who have received percutaneous coronary intervention (PCI). To evaluate patterns of cardiac testing including CCTA after PCI, we created a retrospective o ... Full text Link to item Cite

Early anticoagulation of bioprosthetic aortic valves in older patients: results from the Society of Thoracic Surgeons Adult Cardiac Surgery National Database.

Journal article J Am Coll Cardiol · September 11, 2012 OBJECTIVES: The aim of this study was to evaluate the risks and benefits of short-term anticoagulation in patients receiving aortic valve bioprostheses. BACKGROUND: Patients receiving aortic valve bioprostheses have an elevated early risk of thromboembolic ... Full text Link to item Cite

ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS 2012 appropriate use criteria for diagnostic catheterization: American College of Cardiology Foundation Appropriate Use Criteria Task Force Society for Cardiovascular Angiography and Interventions American Association for Thoracic Surgery American Heart Association, American Society of Echocardiography American Society of Nuclear Cardiology Heart Failure Society of America Heart Rhythm Society, Society of Critical Care Medicine Society of Cardiovascular Computed Tomography Society for Cardiovascular Magnetic Resonance Society of Thoracic Surgeons.

Journal article Catheter Cardiovasc Interv · September 1, 2012 The American College of Cardiology Foundation, in collaboration with the Society for Cardiovascular Angiography and Interventions and key specialty and subspecialty societies, conducted a review of common clinical scenarios where diagnostic catheterization ... Full text Link to item Cite

Future directions for cardiovascular disease comparative effectiveness research: report of a workshop sponsored by the National Heart, Lung, and Blood Institute.

Journal article J Am Coll Cardiol · August 14, 2012 Comparative effectiveness research (CER) aims to provide decision makers with the evidence needed to evaluate the benefits and harms of alternative clinical management strategies. CER has become a national priority, with considerable new research funding a ... Full text Link to item Cite

Association between endoscopic vs open vein-graft harvesting and mortality, wound complications, and cardiovascular events in patients undergoing CABG surgery.

Journal article JAMA · August 1, 2012 CONTEXT: The safety and durability of endoscopic vein graft harvest in coronary artery bypass graft (CABG) surgery has recently been called into question. OBJECTIVE: To compare the long-term outcomes of endoscopic vs open vein-graft harvesting for Medicare ... Full text Link to item Cite

Cardiologist concordance with the American College of Cardiology appropriate use criteria for cardiac testing in patients with coronary artery disease.

Journal article Am J Cardiol · August 1, 2012 The American College of Cardiology Appropriate Use Criteria (AUC) were developed to guide use of myocardial perfusion single-photon emission computed tomography (MPS), stress echocardiography, and cardiac computed tomographic angiography (CCTA). To date, c ... Full text Link to item Cite

ACCF/ACR/AIUM/ASE/ASN/ICAVL/SCAI/SCCT/SIR/SVM/SVS/SVU [corrected] 2012 appropriate use criteria for peripheral vascular ultrasound and physiological testing part I: arterial ultrasound and physiological testing: a report of the American College of Cardiology Foundation appropriate use criteria task force, American College of Radiology, American Institute of Ultrasound in Medicine, American Society of Echocardiography, American Society of Nephrology, Intersocietal Commission for the Accreditation of Vascular Laboratories, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Interventional Radiology, Society for Vascular Medicine, Society for Vascular Surgery, [corrected] and Society for Vascular Ultrasound. [corrected].

Journal article J Am Coll Cardiol · July 17, 2012 The American College of Cardiology Foundation (ACCF), in partnership with key specialty and subspecialty societies, conducted a review of common clinical scenarios where noninvasive vascular testing (ultrasound and physiological testing) is frequently cons ... Full text Link to item Cite

Cardiopulmonary function and age-related decline across the breast cancer survivorship continuum.

Journal article J Clin Oncol · July 10, 2012 PURPOSE: To evaluate cardiopulmonary function (as measured by peak oxygen consumption [VO(2peak)]) across the breast cancer continuum and its prognostic significance in women with metastatic disease. PATIENTS AND METHODS: Patients with breast cancer repres ... Full text Link to item Cite

Developing an action plan for patient radiation safety in adult cardiovascular medicine. Proceedings from the Duke University Clinical Research Institute/American College of Cardiology Foundation/American Heart Association Think Tank Held on February 28, 2011.

Journal article J Nucl Cardiol · June 2012 Technological advances and increased utilization of medical testing and procedures have prompted greater attention to ensuring the patient safety of radiation use in the practice of adult cardiovascular medicine. In response, representatives from cardiovas ... Full text Link to item Cite

Optimal surgical management of severe ischemic mitral regurgitation: to repair or to replace?

Journal article J Thorac Cardiovasc Surg · June 2012 BACKGROUND: Ischemic mitral regurgitation, a complication of myocardial infarction and coronary artery disease more generally, is associated with a high mortality rate and is estimated to affect 2.8 million Americans. With 1-year mortality rates as high as ... Full text Link to item Cite

ACCF/SCAI/AATS/AHA/ASE/ASNC/HFSA/HRS/SCCM/SCCT/SCMR/STS 2012 appropriate use criteria for diagnostic catheterization: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, Society for Cardiovascular Angiography and Interventions, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society of Critical Care Medicine, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons.

Journal article J Am Coll Cardiol · May 29, 2012 The American College of Cardiology Foundation, in collaboration with the Society for Cardiovascular Angiography and Interventions and key specialty and subspecialty societies, conducted a review of common clinical scenarios where diagnostic catheterization ... Full text Link to item Cite

Developing an action plan for patient radiation safety in adult cardiovascular medicine: proceedings from the Duke University Clinical Research Institute/American College of Cardiology Foundation/American Heart Association Think Tank held on February 28, 2011.

Journal article J Am Coll Cardiol · May 15, 2012 Technological advances and increased utilization of medical testing and procedures have prompted greater attention to ensuring the patient safety of radiation use in the practice of adult cardiovascular medicine. In response, representatives from cardiovas ... Full text Link to item Cite

Transcatheter aortic-valve replacement for inoperable severe aortic stenosis.

Journal article N Engl J Med · May 3, 2012 BACKGROUND: Transcatheter aortic-valve replacement (TAVR) is the recommended therapy for patients with severe aortic stenosis who are not suitable candidates for surgery. The outcomes beyond 1 year in such patients are not known. METHODS: We randomly assig ... Full text Link to item Cite

Two-year outcomes after transcatheter or surgical aortic-valve replacement.

Journal article N Engl J Med · May 3, 2012 BACKGROUND: The Placement of Aortic Transcatheter Valves (PARTNER) trial showed that among high-risk patients with aortic stenosis, the 1-year survival rates are similar with transcatheter aortic-valve replacement (TAVR) and surgical replacement. However, ... Full text Link to item Cite

Developing an action plan for patient radiation safety in adult cardiovascular medicine: proceedings from the Duke University Clinical Research Institute/American College of Cardiology Foundation/American Heart Association think tank held on February 28, 2011.

Journal article Circ Cardiovasc Imaging · May 1, 2012 Technological advances and increased utilization of medical testing and procedures have prompted greater attention to ensuring the patient safety of radiation use in the practice of adult cardiovascular medicine. In response, representatives from cardiovas ... Full text Link to item Cite

Hospital percutaneous coronary intervention appropriateness and in-hospital procedural outcomes: insights from the NCDR.

Journal article Circ Cardiovasc Qual Outcomes · May 2012 BACKGROUND: Measurement of hospital quality has traditionally focused on processes of care and postprocedure outcomes. Appropriateness measures for percutaneous coronary intervention (PCI) assess quality as it relates to patient selection and the decision ... Full text Link to item Cite

A practical guide to multimodality imaging of transcatheter aortic valve replacement.

Journal article JACC Cardiovasc Imaging · April 2012 The advent of transcatheter aortic valve replacement (TAVR) is one of the most widely anticipated advances in the care of patients with severe aortic stenosis. This procedure is unique in many ways, one of which is the need for a multimodality imaging team ... Full text Link to item Cite

A meta-analysis and systematic review of computed tomography angiography as a diagnostic triage tool for patients with chest pain presenting to the emergency department.

Journal article J Nucl Cardiol · April 2012 BACKGROUND: To assess clinical utility of computed tomography angiography (CTA) in the diagnosis of chest pain patients presenting to emergency departments (EDs), we conducted a meta-analysis of CTA in patients with suspected acute coronary syndromes (ACSs ... Full text Link to item Cite

ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 appropriate use criteria for coronary revascularization focused update: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, American Association for Thoracic Surgery, American Heart Association, American Society of Nuclear Cardiology, and the Society of Cardiovascular Computed Tomography.

Journal article J Thorac Cardiovasc Surg · April 2012 The American College of Cardiology Foundation (ACCF), Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, and the American Association for Thoracic Surgery, along with key specialty and subspecialty societies, conducted ... Full text Link to item Cite

Exercise rehabilitation in patients with cancer.

Journal article Nat Rev Clin Oncol · March 6, 2012 Emerging evidence indicates that patients with cancer have considerable impairments in cardiorespiratory fitness, which is likely to be a result of the direct toxic effects of anticancer therapy as well as the indirect consequences secondary to therapy (fo ... Full text Link to item Cite

The clinical impact of incomplete left atrial appendage closure with the Watchman Device in patients with atrial fibrillation: a PROTECT AF (Percutaneous Closure of the Left Atrial Appendage Versus Warfarin Therapy for Prevention of Stroke in Patients With Atrial Fibrillation) substudy.

Journal article J Am Coll Cardiol · March 6, 2012 OBJECTIVES: The purpose of this study was to investigate the frequency and clinical impact of incomplete left atrial appendage (LAA) sealing and consequent peri-device residual blood flow in patients undergoing percutaneous LAA closure with the Watchman de ... Full text Link to item Cite

TEMPORAL TRENDS IN PERCUTANEOUS CORONARY INTERVENTION OUTCOMES AMONG OLDER PATIENTS

Journal article Journal of the American College of Cardiology · March 2012 Full text Cite

Downstream procedures and outcomes after stress testing for chest pain without known coronary artery disease in the United States.

Journal article Am Heart J · March 2012 BACKGROUND: Millions of Americans with suspected coronary artery disease undergo noninvasive cardiac stress testing annually. Downstream procedures and subsequent outcomes among symptomatic patients without known coronary disease referred for stress testin ... Full text Link to item Cite

ACCF/SCAI/STS/AATS/AHA/ASNC/HFSA/SCCT 2012 Appropriate use criteria for coronary revascularization focused update: a report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, American Association for Thoracic Surgery, American Heart Association, American Society of Nuclear Cardiology, and the Society of Cardiovascular Computed Tomography.

Journal article J Am Coll Cardiol · February 28, 2012 The American College of Cardiology Foundation (ACCF), Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, and the American Association for Thoracic Surgery, along with key specialty and subspecialty societies, conducted ... Full text Link to item Cite

Characteristics and long-term outcomes of percutaneous revascularization of unprotected left main coronary artery stenosis in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.

Journal article J Am Coll Cardiol · February 14, 2012 OBJECTIVES: This study sought to assess percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) stenosis in routine U.S. clinical practice. BACKGROUND: Percutaneous coronary intervention for ULMCA stenosis is controversia ... Full text Link to item Cite

A comparative evaluation of transesophageal and transthoracic echocardiography for measurement of left ventricular systolic strain using speckle tracking.

Journal article J Cardiothorac Vasc Anesth · February 2012 OBJECTIVE: The authors hypothesized that the measurement of strain by speckle tracking with transesophageal echocardiography (TEE) is feasible and comparable to transthoracic echocardiography (TTE). DESIGN: A prospective observational comparative study. SE ... Full text Link to item Cite

Percutaneous coronary intervention and drug-eluting stent use among patients ≥85 years of age in the United States.

Journal article J Am Coll Cardiol · January 10, 2012 OBJECTIVES: This study assessed the comparative effectiveness of drug-eluting stents (DES) versus bare-metal stents (BMS) among patients ≥85 years of age. BACKGROUND: Despite an aging population, little is known about the comparative effectiveness of DES v ... Full text Link to item Cite

Linking the National Cardiovascular Data Registry CathPCI Registry with Medicare claims data: validation of a longitudinal cohort of elderly patients undergoing cardiac catheterization.

Journal article Circ Cardiovasc Qual Outcomes · January 2012 BACKGROUND: The National Cardiovascular Data Registry CathPCI Registry was recently linked with longitudinal Centers for Medicare & Medicaid (CMS) claims data. The degree to which this linked cohort is representative of the overall CathPCI Registry and CMS ... Full text Link to item Cite

Association between physician billing and cardiac stress testing patterns following coronary revascularization.

Journal article JAMA · November 9, 2011 CONTEXT: The degree to which financial factors may influence use of cardiac stress imaging procedures is unknown. OBJECTIVE: To examine the association of physician billing and nuclear stress and stress echocardiography testing following coronary revascula ... Full text Link to item Cite

Safety and efficacy of drug-eluting stents in older patients with chronic kidney disease: a report from the linked CathPCI Registry-CMS claims database.

Journal article J Am Coll Cardiol · October 25, 2011 OBJECTIVES: The purpose of this study was to determine the safety and efficacy of drug-eluting stents (DES) compared with bare-metal stents (BMS) in older patients with chronic kidney disease (CKD). BACKGROUND: DES may be associated with late death and myo ... Full text Link to item Cite

ACCF/AHA methodology for the development of quality measures for cardiovascular technology: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures.

Journal article Circulation · September 27, 2011 Consistent with the growing national focus on healthcare quality, the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) have taken a leadership role over the past decade in developing measures of the quality of cardi ... Full text Link to item Cite

ACCF/AHA methodology for the development of quality measures for cardiovascular technology: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Performance Measures.

Journal article J Am Coll Cardiol · September 27, 2011 Consistent with the growing national focus on healthcare quality, the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA) have taken a leadership role over the past decade in developing measures of the quality of cardi ... Full text Link to item Cite

Hospital variability in the rate of finding obstructive coronary artery disease at elective, diagnostic coronary angiography.

Journal article J Am Coll Cardiol · August 16, 2011 OBJECTIVES: The purpose of this study was to describe hospital variability in the rate of finding obstructive coronary artery disease (CAD) at elective coronary angiography. BACKGROUND: A recent national study found that obstructive CAD was found in less t ... Full text Link to item Cite

Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities.

Journal article Radiology · June 2011 UNLABELLED: Quantitative imaging biomarkers could speed the development of new treatments for unmet medical needs and improve routine clinical care. However, it is not clear how the various regulatory and nonregulatory (eg, reimbursement) processes (often ... Full text Open Access Link to item Cite

The incidence and long-term clinical outcome of iatrogenic atrial septal defects secondary to transseptal catheterization with a 12F transseptal sheath.

Journal article Circ Arrhythm Electrophysiol · April 2011 BACKGROUND: Studies assessing the presence of a residual iatrogenic atrial septal defect (iASD) after transseptal catheterization with 8F transseptal sheaths have suggested that the majority of these iASDs close within 6 months. However, these studies have ... Full text Link to item Cite

ACCF/ASE/AHA/ASNC/HFSA/HRS/SCAI/SCCM/SCCT/SCMR 2011 Appropriate Use Criteria for Echocardiography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, American Society of Echocardiography, American Heart Association, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Critical Care Medicine, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance American College of Chest Physicians.

Journal article J Am Soc Echocardiogr · March 2011 The American College of Cardiology Foundation (ACCF), in partnership with the American Society of Echocardiography (ASE) and along with key specialty and subspecialty societies, conducted a review of common clinical scenarios where echocardiography is freq ... Full text Link to item Cite

Impact of early surgery on survival of patients with severe mitral regurgitation.

Journal article Heart · February 2011 BACKGROUND: Optimal timing of surgery in degenerative mitral regurgitation (MR) remains a controversial topic. The impact of current ACC/AHA guideline recommendations about optimal timing of surgery on outcomes is untested and contemporary data are lacking ... Full text Link to item Cite

Assessment of left ventricular function in older Medicare beneficiaries with newly diagnosed heart failure.

Journal article Circ Cardiovasc Qual Outcomes · January 1, 2011 BACKGROUND: Assessment of left ventricular function is a recommended performance measure for the care of patients with newly diagnosed heart failure. Little is known about the extent to which left ventricular function is assessed in real-world settings. ME ... Full text Link to item Cite

Cardiovascular screening in asymptomatic adults: lessons for the diving world.

Journal article Undersea Hyperb Med · 2011 At the broadest level, consensus preparticipation recommendations for athletes of all ages focus on performance of a history and physical examination, with the additional performance of a screening test being more controversial. Depending upon athlete age ... Link to item Cite

ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance.

Journal article Circulation · November 23, 2010 The American College of Cardiology Foundation, along with key specialty and subspecialty societies, conducted an appropriate use review of common clinical scenarios where cardiac computed tomography (CCT) is frequently considered. The present document is a ... Full text Link to item Cite

Ionizing radiation exposure to patients admitted with acute myocardial infarction in the United States.

Journal article Circulation · November 23, 2010 BACKGROUND: Invasive and noninvasive cardiovascular imaging is beneficial in the care of patients admitted with acute myocardial infarction. Little is known about patients' cumulative radiation exposure. METHODS AND RESULTS: All patients admitted with an a ... Full text Link to item Cite

Pulmonary hypertension and long-term mortality in aortic and mitral regurgitation.

Journal article Am J Med · November 2010 BACKGROUND: Outcomes data in patients with aortic regurgitation or mitral regurgitation have been limited to small series with generally <10 years of follow-up. The quantitative impact of pulmonary artery hypertension has not been well described. The purpo ... Full text Link to item Cite

Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery.

Journal article N Engl J Med · October 21, 2010 BACKGROUND: Many patients with severe aortic stenosis and coexisting conditions are not candidates for surgical replacement of the aortic valve. Recently, transcatheter aortic-valve implantation (TAVI) has been suggested as a less invasive treatment for hi ... Full text Link to item Cite

Patterns of cardiac stress testing after revascularization in community practice.

Journal article J Am Coll Cardiol · October 12, 2010 OBJECTIVES: The purpose of this study was to determine the pattern of cardiac stress testing after coronary revascularization in community practice. BACKGROUND: The American College of Cardiology Foundation appropriate use criteria provide guidance for the ... Full text Link to item Cite

Rationale and design of the Exercise Intensity Trial (EXCITE): A randomized trial comparing the effects of moderate versus moderate to high-intensity aerobic training in women with operable breast cancer.

Journal article BMC Cancer · October 6, 2010 BACKGROUND: The Exercise Intensity Trial (EXcITe) is a randomized trial to compare the efficacy of supervised moderate-intensity aerobic training to moderate to high-intensity aerobic training, relative to attention control, on aerobic capacity, physiologi ... Full text Open Access Link to item Cite

The authors reply

Journal article New England Journal of Medicine · July 1, 2010 Cite

Low Diagnostic Yield of Elective Coronary Angiography REPLY

Journal article NEW ENGLAND JOURNAL OF MEDICINE · July 1, 2010 Link to item Cite

The lung cancer exercise training study: a randomized trial of aerobic training, resistance training, or both in postsurgical lung cancer patients: rationale and design.

Journal article BMC Cancer · April 21, 2010 BACKGROUND: The Lung Cancer Exercise Training Study (LUNGEVITY) is a randomized trial to investigate the efficacy of different types of exercise training on cardiorespiratory fitness (VO2peak), patient-reported outcomes, and the organ components that gover ... Full text Open Access Link to item Cite

Low diagnostic yield of elective coronary angiography.

Journal article N Engl J Med · March 11, 2010 BACKGROUND: Guidelines for triaging patients for cardiac catheterization recommend a risk assessment and noninvasive testing. We determined patterns of noninvasive testing and the diagnostic yield of catheterization among patients with suspected coronary a ... Full text Link to item Cite

Cardiovascular imaging research at the crossroads.

Journal article JACC Cardiovasc Imaging · March 2010 Cardiovascular (CV) imaging plays a critical role in therapeutic decision making and is performed in more than 10 million patients each year; a large share of the nearly 40 million patients living with CV disease. CV imaging may serve as a valuable compone ... Full text Link to item Cite

Representation of women in randomized clinical trials of cardiovascular disease prevention.

Journal article Circ Cardiovasc Qual Outcomes · March 2010 BACKGROUND: The 2007 American Heart Association guidelines for cardiovascular disease prevention in women drew heavily on results from randomized clinical trials; however, representation of women in trials of cardiovascular disease prevention has not been ... Full text Link to item Cite

Reply

Journal article Journal of the American College of Cardiology · January 19, 2010 Full text Cite

A multicenter assessment of the use of single-photon emission computed tomography myocardial perfusion imaging with appropriateness criteria.

Journal article J Am Coll Cardiol · January 12, 2010 OBJECTIVES: The aim of this study was to assess the feasibility of evaluation for appropriate use of radionuclide myocardial perfusion imaging (MPI) in multiple clinical sites and to determine use patterns as well as identify areas of apparent inappropriat ... Full text Link to item Cite

Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast.

Journal article J Natl Cancer Inst Monogr · 2010 Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women w ... Full text Link to item Cite

ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography. A Report of the American College of Cardiology Foundation Appropriate Use Criteria Task Force, the Society of Cardiovascular Computed Tomography, the American College of Radiology, the American Heart Association, the American Society of Echocardiography, the American Society of Nuclear Cardiology, the North American Society for Cardiovascular Imaging, the Society for Cardiovascular Angiography and Interventions, and the Society for Cardiovascular Magnetic Resonance.

Journal article J Cardiovasc Comput Tomogr · 2010 The American College of Cardiology Foundation (ACCF), along with key specialty and subspecialty societies, conducted an appropriate use review of common clinical scenarios where cardiac computed tomography (CCT) is frequently considered. The present docume ... Full text Link to item Cite

Sex differences in mortality following acute coronary syndromes.

Journal article JAMA · August 26, 2009 CONTEXT: Conflicting information exists about whether sex differences modulate short-term mortality following acute coronary syndromes (ACS). OBJECTIVES: To investigate the relationship between sex and 30-day mortality in ACS, and to determine whether this ... Full text Link to item Cite

Increasing healthcare resource utilization after coronary artery bypass graft surgery in the United States.

Journal article Circ Cardiovasc Qual Outcomes · July 2009 BACKGROUND: Despite declining lengths of stay, postdischarge healthcare resource utilization may be increasing because of shifts to nonacute care settings. Although changes in hospital stay after coronary artery bypass graft (CABG) surgery have been descri ... Full text Link to item Cite

Outcomes research in cardiovascular imaging: report of a workshop sponsored by the National Heart, Lung, and Blood Institute.

Journal article Circ Cardiovasc Imaging · July 2009 In July of 2008, the National Heart, Lung, and Blood Institute convened experts in noninvasive cardiovascular imaging, outcomes research, statistics, and clinical trials to develop recommendations for future randomized controlled trials of the use of imagi ... Full text Link to item Cite

Outcomes research in cardiovascular imaging: report of a workshop sponsored by the National Heart, Lung, and Blood Institute.

Journal article JACC Cardiovasc Imaging · July 2009 In July of 2008, the National Heart, Lung, and Blood Institute convened experts in noninvasive cardiovascular imaging, outcomes research, statistics, and clinical trials to develop recommendations for future randomized controlled trials of the use of imagi ... Full text Link to item Cite

Outcomes research in cardiovascular imaging: report of a workshop sponsored by the National Heart, Lung, and Blood Institute.

Journal article J Am Soc Echocardiogr · July 2009 In July of 2008, the National Heart, Lung, and Blood Institute convened experts in noninvasive cardiovascular imaging, outcomes research, statistics, and clinical trials to develop recommendations for future randomized controlled trials of the use of imagi ... Full text Link to item Cite

Clinical effectiveness of coronary stents in elderly persons: results from 262,700 Medicare patients in the American College of Cardiology-National Cardiovascular Data Registry.

Journal article J Am Coll Cardiol · May 5, 2009 OBJECTIVES: The aim of this study was to compare outcomes in older individuals receiving drug-eluting stents (DES) and bare-metal stents (BMS). BACKGROUND: Comparative effectiveness of DES relative to BMS remains unclear. METHODS: Outcomes were evaluated i ... Full text Link to item Cite

Patterns of Cardiac Stress Testing After Revascularization in Community Practice

Journal article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 10, 2009 Link to item Cite

Reporting and Representation of Race in Published Randomized Trials

Journal article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 10, 2009 Link to item Cite

ACCF/SCAI/STS/AATS/AHA/ASNC 2009 Appropriateness Criteria for Coronary Revascularization : a report of the American College of Cardiology Foundation Appropriateness Criteria Task Force, Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, American Association for Thoracic Surgery, American Heart Association, and the American Society of Nuclear Cardiology. Endorsed by the American Society of Echocardiography, the Heart Failure Society of America, and the Society of Cardiovascular Computed Tomography.

Journal article Catheter Cardiovasc Interv · February 15, 2009 The American College of Cardiology Foundation (ACCF), Society for Cardiovascular Angiography and Interventions, Society of Thoracic Surgeons, and the American Association for Thoracic Surgery, along with key specialty and subspecialty societies, conducted ... Full text Link to item Cite

Achieving Quality in Cardiovascular Imaging II: proceedings from the Second American College of Cardiology -- Duke University Medical Center Think Tank on Quality in Cardiovascular Imaging.

Journal article JACC Cardiovasc Imaging · February 2009 Despite rapid technologic advances and sustained growth, less attention has been focused on quality in imaging than in other areas of cardiovascular medicine. To address this deficit, representatives from cardiovascular imaging societies, private payers, g ... Full text Link to item Cite

Outcomes research in cardiovascular imaging: report of a workshop sponsored by the National Heart, Lung, and Blood Institute.

Journal article J Cardiovasc Comput Tomogr · 2009 In July of 2008, the National Heart, Lung, and Blood Institute convened experts in noninvasive cardiovascular imaging, outcomes research, statistics, and clinical trials to develop recommendations for future randomized controlled trials of the use of imagi ... Full text Link to item Cite

Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients: a pilot study.

Journal article Cancer · December 15, 2008 BACKGROUND: A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted. METHODS: Using a single-group ... Full text Link to item Cite

Saving athletes' lives a reason to find common ground?

Journal article J Am Coll Cardiol · December 9, 2008 Although both U.S. and European guidelines recommend screening athletes for suspected heart disease before participation in competitive sport, they disagree on which findings are associated with increased risk as well as those athletes whose activities sho ... Full text Link to item Cite

The Imaging Council of the American College of Cardiology.

Journal article JACC Cardiovasc Imaging · November 2008 Full text Link to item Cite

Improving the quality of care for women with cardiovascular disease: report of a DCRI Think Tank, March 8 to 9, 2007.

Journal article Am Heart J · November 2008 BACKGROUND: Differences in pathophysiology, diagnosis, and treatment of women with cardiovascular disease compared with men has become a major focus during the past decade. Nevertheless, little attention has focused on improving the quality of healthcare i ... Full text Link to item Cite

Defining optimal research study design for cardiovascular imaging using computed tomography angiography as a model.

Journal article Am J Cardiol · October 1, 2008 Patients, physicians, and payers are facing a significant increase in cardiovascular (CV) imaging use, resulting in skyrocketing societal costs, without clear improvement in patient outcomes. The need for studies evaluating the effects of CV imaging that a ... Full text Link to item Cite

Extracardiac findings: what is a cardiologist to do?

Journal article JACC Cardiovasc Imaging · September 2008 Full text Link to item Cite

Quality in echocardiography: choosing to succeed.

Journal article J Am Soc Echocardiogr · September 2008 Full text Link to item Cite

Cardiorespiratory exercise testing in clinical oncology research: systematic review and practice recommendations.

Journal article Lancet Oncol · August 2008 The use of exercise testing as an objective assessment of cardiorespiratory fitness in clinical oncology research has increased substantially over the past decade. However, its quality has not been assessed. We did a systematic review of studies of formal ... Full text Link to item Cite

The multimodality imager: reality or fantasy?

Journal article JACC Cardiovasc Imaging · July 2008 Full text Link to item Cite

Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology-National Cardiovascular Data Registry.

Journal article Circulation · April 8, 2008 BACKGROUND: Although populations referred for coronary angiography are increasingly diverse, there is limited information on coronary artery disease (CAD) prevalence and in-hospital mortality other than for predominately white male patients. METHODS AND RE ... Full text Link to item Cite

ACCF/ASE/ACEP/AHA/ASNC/SCAI/SCCT/SCMR 2008 Appropriateness Criteria for Stress Echocardiography. A report of the American College of Cardiology Foundation Appropriateness Criteria Task Force, American Society of Echocardiography, American College of Emergency Physicians, American Heart Association, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance endorsed by the Heart Rhythm Society and the Society of Critical Care Medicine.

Journal article Catheter Cardiovasc Interv · April 1, 2008 The American College of Cardiology Foundation (ACCF) and the American Society of Echocardiography (ASE) together with key specialty and subspecialty societies, conducted an appropriateness review for stress echocardiography. The review assessed the risks a ... Full text Link to item Cite

Reply

Journal article Journal of the American College of Cardiology · March 25, 2008 Full text Cite

ACCF/ASE/ACEP/AHA/ASNC/SCAI/SCCT/SCMR 2008 appropriateness criteria for stress echocardiography: a report of the American College of Cardiology Foundation Appropriateness Criteria Task Force, American Society of Echocardiography, American College of Emergency Physicians, American Heart Association, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance: endorsed by the Heart Rhythm Society and the Society of Critical Care Medicine.

Journal article Circulation · March 18, 2008 The American College of Cardiology Foundation (ACCF) and the American Society of Echocardiography (ASE) together with key specialty and subspecialty societies, conducted an appropriateness review for stress echocardiography. The review assessed the risks a ... Full text Link to item Cite

ACCF/ASE/ACEP/AHA/ASNC/SCAI/SCCT/SCMR 2008 appropriateness criteria for stress echocardiography: a report of the American College of Cardiology Foundation Appropriateness Criteria Task Force, American Society of Echocardiography, American College of Emergency Physicians, American Heart Association, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance endorsed by the Heart Rhythm Society and the Society of Critical Care Medicine.

Journal article J Am Coll Cardiol · March 18, 2008 The American College of Cardiology Foundation (ACCF) and the American Society of Echocardiography (ASE) together with key specialty and subspecialty societies, conducted an appropriateness review for stress echocardiography. The review assessed the risks a ... Full text Link to item Cite

Clinical genomic testing: getting it right.

Journal article J Cardiovasc Transl Res · March 2008 Full text Link to item Cite

Imaging for coronary risk assessment: ready for prime time?

Journal article JACC Cardiovasc Imaging · March 2008 Full text Link to item Cite

Contrast echocardiography: past, present, and...future?

Journal article JACC Cardiovasc Imaging · January 2008 Full text Link to item Cite

Training cardiovascular specialists in imaging: a curriculum based on fundamental concepts required for multimodal imaging.

Journal article Am Heart J · November 2007 BACKGROUND: Training cardiovascular (CV) imaging specialists is becoming increasingly complex owing to rapidly emerging technological advances and the growing recognition that single modality training is inefficient and results in suboptimal education and ... Full text Link to item Cite

Early breast cancer therapy and cardiovascular injury.

Journal article J Am Coll Cardiol · October 9, 2007 Although recent advances in curative-intent therapies are beginning to produce significant survival gains in early breast cancer, these improvements may ultimately be attenuated by increased risk of long-term cardiovascular mortality. This paper reviews em ... Full text Link to item Cite

Left ventricular hypertrophy in athletes: morphologic features and clinical correlates.

Journal article Cardiol Clin · August 2007 The athlete's heart is a constellation of cardiac morphologic changes, including increased left ventricular volume, increased left ventricular mass, increased left atrial volume, and right ventricular structural changes as a physiologic response to exercis ... Full text Link to item Cite

Evolving trends in the use of echocardiography: a study of Medicare beneficiaries.

Journal article J Am Coll Cardiol · June 12, 2007 OBJECTIVES: We studied the use of echocardiography among Medicare beneficiaries between 1999 and 2004 to determine the rate of growth in these services and evaluate the drivers of growth. BACKGROUND: Concerned about increasing health care costs, federal an ... Full text Link to item Cite

Relation between number of component views and accuracy of left ventricular mass determined by three-dimensional echocardiography.

Journal article Am J Cardiol · May 1, 2007 Three-dimensional echocardiography (3DE) allows the accurate determination of left ventricular (LV) mass, but the optimal number of component or extracted 2-dimensional (2D) image planes that should be used to calculate LV mass is not known. This study was ... Full text Link to item Cite

Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: a pooled analysis of 5 randomized control trials.

Journal article J Am Coll Cardiol · April 3, 2007 OBJECTIVES: This study sought to explore the gender-related differences in etiology and outcomes in chronic heart failure (HF) patients from 5 randomized trials. BACKGROUND: Each year, 550,000 new cases of HF are identified; however, there remain limited d ... Full text Link to item Cite

Predictors of carotid intima-media thickness progression in young adults: the Bogalusa Heart Study.

Journal article Stroke · March 2007 BACKGROUND AND PURPOSE: We sought to evaluate the predictors of carotid intima-media thickness (CIMT) progression in young adults and to determine whether they differed between the sexes. Although risk factors for the progression of atherosclerosis in midd ... Full text Link to item Cite

Distribution and predictors of carotid intima-media thickness in young adults.

Journal article Prev Cardiol · 2007 The authors' aim was to determine reference values and predictors for carotid intima-media thickness (CIMT) in the Bogalusa Heart Study. Carotid ultrasound images from 1203 young adults (mean age 36 years; 30% black, 43% male) were reviewed. Age-, sex-, an ... Full text Link to item Cite

Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon.

Journal article Circulation · November 28, 2006 BACKGROUND: Multiple studies have individually documented cardiac dysfunction and biochemical evidence of cardiac injury after endurance sports; however, convincing associations between the two are lacking. We aimed to determine the associations between th ... Full text Link to item Cite

Achieving quality in cardiovascular imaging: proceedings from the American College of Cardiology-Duke University Medical Center Think Tank on Quality in Cardiovascular Imaging.

Journal article J Am Coll Cardiol · November 21, 2006 Cardiovascular imaging has enjoyed both rapid technological advances and sustained growth, yet less attention has been focused on quality than in other areas of cardiovascular medicine. To address this deficit, representatives from cardiovascular imaging s ... Full text Link to item Cite

Improving imaging: our professional imperative.

Journal article J Am Coll Cardiol · November 21, 2006 Many factors, including disproportionate growth rates and exciting new technologies, have focused attention on cardiovascular imaging. However, critical examination of the field reveals a surprisingly weak evidence base and inconsistent systematic attentio ... Full text Link to item Cite

Myocardial adaptation to short-term high-intensity exercise in highly trained athletes.

Journal article J Am Soc Echocardiogr · October 2006 We aimed to clarify the myocardial adaptation to short-term high-intensity exercise among trained athletes. We screened 17 participants in the 2004 World Indoor Rowing Championships before and after a 2000-m sprint. Echocardiography included standard measu ... Full text Link to item Cite

Angiotensin-converting enzyme genotype predicts cardiac and autonomic responses to prolonged exercise.

Journal article J Am Coll Cardiol · August 1, 2006 OBJECTIVES: The purpose of this study was to investigate the phenomenon of left ventricular (LV) dysfunction after ultraendurance exercise. BACKGROUND: Subclinical LV dysfunction in response to endurance exercise up to 24 h duration has been described, but ... Full text Link to item Cite

President's Page: John C. (Jack) Lewin, MD: From Rural Maui to CEO of the American College of Cardiology

Journal article Journal of the American College of Cardiology · August 1, 2006 Full text Cite

From vulnerable plaque to vulnerable patient--Part III: Executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report.

Journal article Am J Cardiol · July 17, 2006 Screening for early-stage asymptomatic cancers (eg, cancers of breast and colon) to prevent late-stage malignancies has been widely accepted. However, although atherosclerotic cardiovascular disease (eg, heart attack and stroke) accounts for more death and ... Full text Link to item Cite

Left atrial size: physiologic determinants and clinical applications.

Journal article J Am Coll Cardiol · June 20, 2006 Left atrial (LA) enlargement has been proposed as a barometer of diastolic burden and a predictor of common cardiovascular outcomes such as atrial fibrillation, stroke, congestive heart failure, and cardiovascular death. It has been shown that advancing ag ... Full text Link to item Cite

Persistent and reversible cardiac dysfunction among amateur marathon runners.

Journal article Eur Heart J · May 2006 AIMS: Transient systolic and diastolic abnormalities in ventricular function have previously been documented during endurance sports. However, these described alterations may be limited by the techniques applied. We sought, using less load-dependent method ... Full text Link to item Cite

President's page: making imaging meaningful.

Journal article J Am Coll Cardiol · April 4, 2006 Full text Link to item Cite

President's page: Collaborative culture key to our success.

Journal article J Am Coll Cardiol · February 7, 2006 Full text Link to item Cite

Coming together to achieve quality cardiovascular care.

Journal article J Am Coll Cardiol · January 3, 2006 Full text Link to item Cite

Age-related changes in cardiac structure and function in Fischer 344 x Brown Norway hybrid rats.

Journal article Am J Physiol Heart Circ Physiol · January 2006 The effects of aging on cardiovascular function and cardiac structure were determined in a rat model recommended for gerontological studies. A cross-sectional analysis assessed cardiac changes in male Fischer 344 x Brown Norway F1 hybrid rats (FBN) from ad ... Full text Link to item Cite

Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types.

Journal article J Mol Cell Cardiol · January 2006 Initial studies have suggested that transplantation of embryonic stem (ES) cells following myocardial infarction (MI) in animal models is beneficial; however, the mechanism of benefit is largely unknown. The present study investigated the fate of mouse ES ... Full text Link to item Cite

Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials.

Journal article Lancet · December 17, 2005 BACKGROUND: In early breast cancer, variations in local treatment that substantially affect the risk of locoregional recurrence could also affect long-term breast cancer mortality. To examine this relationship, collaborative meta-analyses were undertaken, ... Full text Link to item Cite

ACCF/ASNC appropriateness criteria for single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI): a report of the American College of Cardiology Foundation Quality Strategic Directions Committee Appropriateness Criteria Working Group and the American Society of Nuclear Cardiology endorsed by the American Heart Association.

Journal article J Am Coll Cardiol · October 18, 2005 Under the auspices of the American College of Cardiology Foundation (ACCF) and the American Society of Nuclear Cardiology (ASNC), an appropriateness review was conducted for radionuclide cardiovascular imaging (RNI), specifically gated single-photon emissi ... Full text Link to item Cite

Where does fitness fit in?

Journal article N Engl J Med · August 4, 2005 Full text Link to item Cite

Increased subclinical atherosclerosis in young adults with metabolic syndrome: the Bogalusa Heart Study.

Journal article J Am Coll Cardiol · August 2, 2005 OBJECTIVES: The purpose of this study was to investigate the association of metabolic syndrome (MetS) with subclinical atherosclerosis, determined by ultrasound carotid intima-media thickness (CIMT) measurements, in young adults. BACKGROUND: Metabolic synd ... Full text Link to item Cite

President's page: Education: Drudgery or excitement? You choose

Journal article Journal of the American College of Cardiology · August 2, 2005 Full text Cite

The master female athlete.

Journal article Med Sci Sports Exerc · August 2005 Full text Link to item Cite

The cardiovascular evaluation of women athletes.

Journal article Med Sci Sports Exerc · August 2005 Full text Link to item Cite

President's Page: Quality: it's in your hands.

Journal article J Am Coll Cardiol · June 7, 2005 Full text Link to item Cite

Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.

Journal article Lancet · May 14, 2005 BACKGROUND: Quinquennial overviews (1985-2000) of the randomised trials in early breast cancer have assessed the 5 year and 10-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival. Here, we report the 10-year and 15- ... Full text Link to item Cite

Advanced lipoprotein testing does not improve identification of subclinical atherosclerosis in young adults: the Bogalusa Heart Study.

Journal article Ann Intern Med · May 3, 2005 BACKGROUND: The clinical value of advanced lipoprotein testing relative to traditional lipid testing remains controversial. To date, no studies have evaluated associations between advanced lipoprotein testing and subclinical atherosclerosis in healthy youn ... Full text Link to item Cite

Task Force 3: valvular heart disease.

Journal article J Am Coll Cardiol · April 19, 2005 Full text Link to item Cite

Upon convocation: dream big, love big.

Journal article J Am Coll Cardiol · April 5, 2005 Full text Link to item Cite

A semiautomated ultrasound border detection program that facilitates clinical measurement of ultrasound carotid intima-media thickness.

Journal article J Am Soc Echocardiogr · March 2005 We have developed a novel, semiautomated carotid intima-media thickness (CIMT) border detection program (AUTO) and evaluated its measurement reproducibility and accuracy. Images from 6 carotid segments were acquired in 50 subjects, for a total of 300 segme ... Full text Link to item Cite

Distinct mouse coronary anatomy and myocardial infarction consequent to ligation.

Journal article Coron Artery Dis · February 2005 UNLABELLED: This study describes the coronary anatomy of C57BL/6 mice and the functional impact of that anatomy on myocardial infarctions induced by ligation of the left coronary artery. In contrast to humans, a distinct septal coronary artery was observed ... Full text Link to item Cite

Distribution and cross-sectional age-related increases of carotid artery intima-media thickness in young adults: the Bogalusa Heart Study.

Journal article Stroke · December 2004 BACKGROUND AND PURPOSE: Reference values and age-related changes of carotid intima-media thickness (CIMT) have not been described in a community-based sample of young asymptomatic adults. CIMT measurements from the Bogalusa Heart Study, a study of the natu ... Full text Link to item Cite

A time of accelerated change in academic cardiovascular medicine: implications for academic divisions of cardiology and their training programs.

Journal article J Am Coll Cardiol · November 16, 2004 With the vast epidemic of vascular disease predicted to be the leading cause of death and disability by a growing margin over the next 30 years, academic medical centers with cardiology training programs have a special responsibility. Given the dramatic ad ... Full text Link to item Cite

Vascular age: integrating carotid intima-media thickness measurements with global coronary risk assessment.

Journal article Clin Cardiol · July 2004 BACKGROUND: An imaging test that quantifies atherosclerotic burden and that can be integrated with existing risk stratification paradigms would be a very useful clinical tool. HYPOTHESIS: Measurement of carotid intima-media thickness (CIMT) is feasible in ... Full text Link to item Cite

LVAD as destination therapy - The economic dilemma

Journal article IEEE Technology and Society Magazine · June 1, 2004 The Left Ventricular Assist Device (LVAD) is now an FDA-approved practical remedy for people with failing hearts. This device typically bypasses the left ventricle and pumps blood directly into the aorta, from which it enters the systematic circulation. Mo ... Full text Cite

Using imaging for cardiovascular risk prediction: an overview.

Journal article J Am Soc Echocardiogr · June 2004 Atherosclerosis is a systemic, silent, and deadly disease; however, primary risk reduction is very effective. Cost-effective risk modification relies on accurate and individualized risk stratification; however, traditional risk factor-based assessments fai ... Full text Link to item Cite

Importance of and Barriers to Including Women in Clinical Trials

Journal article · January 1, 2004 The last decade of the 20th century brought with it an explosion of new genetic information, making it increasingly obvious that many physiologic and pathologic functions are influenced either directly or indirectly by sex-based differences in biology. The ... Full text Cite

President's message - It has been wonderful!

Journal article JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY · June 2003 Link to item Cite

It has been wonderful!

Journal article Journal of the American Society of Echocardiography · June 1, 2003 Cite

President's message - Happy 50th birthday, echocardiography! Part 2

Journal article JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY · May 2003 Link to item Cite

Happy 50th birthday, echocardiography! Part 2

Journal article Journal of the American Society of Echocardiography · May 1, 2003 Cite

President's message: Happy 50th birthday, echocardiography! Part 1

Journal article Journal of the American Society of Echocardiography · April 1, 2003 Cite

President's message beyond echocardiography

Journal article Journal of the American Society of Echocardiography · March 1, 2003 Cite

President's message: ASE's new educational goals

Journal article Journal of the American Society of Echocardiography · February 1, 2003 Cite

The next frontier: vascular ultrasound.

Journal article J Am Soc Echocardiogr · January 2003 Link to item Cite

Where are the sonographers?

Journal article Journal of the American Society of Echocardiography · December 1, 2002 Cite

The echo lab team

Journal article Journal of the American Society of Echocardiography · November 1, 2002 Cite

What a year!

Journal article Journal of the American Society of Echocardiography · August 1, 2002 Cite

What are the top 10 reasons not to use a contrast?

Journal article J Am Soc Echocardiogr · July 2002 Link to item Cite

Metastatic intracardiac tumour from liposarcoma.

Journal article Can J Cardiol · July 2002 Link to item Cite

President's message. Coping.

Journal article J Am Soc Echocardiogr · May 2002 Link to item Cite

Effect of cardiac cycle on ultrasound assessment of endothelial function.

Journal article Vasc Med · May 2002 To investigate the effects of non-ECG-triggered imaging during ultrasound studies of endothelial function, brachial artery diameters were measured throughout the cardiac cycle at rest, during reactive hyperemia, and after administration of nitroglycerin. R ... Full text Link to item Cite

Disease orientation

Journal article Journal of the American Society of Echocardiography · April 1, 2002 Cite

Hand-carried cardiac ultrasound (HCU) device: recommendations regarding new technology. A report from the Echocardiography Task Force on New Technology of the Nomenclature and Standards Committee of the American Society of Echocardiography.

Journal article J Am Soc Echocardiogr · April 2002 The newest introduction to echocardiography is a hand-carried ultrasound (HCU) device. It is a small echocardiographic machine that typically weighs less than 6 lb and can obtain echocardiographic images and data. However, neither the device nor the contex ... Full text Link to item Cite

Akt/protein kinase B promotes organ growth in transgenic mice.

Journal article Mol Cell Biol · April 2002 One of the least-understood areas in biology is the determination of the size of animals and their organs. In Drosophila, components of the insulin receptor phosphoinositide 3-kinase (PI3K) pathway determine body, organ, and cell size. Several biochemical ... Full text Link to item Cite

Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice.

Journal article Circ Res · March 22, 2002 Familial hypertrophic cardiomyopathy (FHC) is an inherited autosomal dominant disease caused by mutations in sarcomeric proteins. Among these, mutations that affect myosin binding protein-C (MyBP-C), an abundant component of the thick filaments, account fo ... Full text Link to item Cite

Beyond digital

Journal article Journal of the American Society of Echocardiography · March 1, 2002 Cite

Assessment of coronary heart disease morbidity and mortality after radiation therapy for early breast cancer.

Journal article J Clin Oncol · February 15, 2002 PURPOSE: To assess the risk of fatal and nonfatal myocardial infarction (MI) after breast-conserving surgery (BCS) and radiation therapy (RT) for left-sided breast cancer. PATIENTS AND METHODS: A hospital-based retrospective cohort linkage study of all bre ... Full text Link to item Cite

Quality: Do you know it when you see it?

Journal article Journal of the American Society of Echocardiography · February 1, 2002 Cite

Education is still number one!

Journal article Journal of the American Society of Echocardiography · January 1, 2002 Cite

Early cardioversion of atrial fibrillation facilitated by transesophageal echocardiography: short-term safety and impact on maintenance of sinus rhythm at 1 year.

Journal article Am J Med · June 15, 2001 BACKGROUND: For patients presenting with atrial fibrillation of only a few weeks duration, the use of transesophageal echocardiography offers the opportunity to markedly abbreviate the duration of atrial fibrillation before cardioversion. We sought to dete ... Full text Link to item Cite

Outcomes research review.

Journal article J Am Soc Echocardiogr · June 2001 Full text Link to item Cite

Transesophageal echocardiographic evaluation of native aortic valve area: utility of the double-envelope technique.

Journal article J Cardiothorac Vasc Anesth · June 2001 OBJECTIVE: To assess the accuracy of aortic valve area (AVA) calculations using the continuity equation with data obtained from the double envelope (DE) (simultaneously obtained left ventricular outflow tract [V1]) and aortic valve [V2] velocities) during ... Full text Link to item Cite

Gender differences in exercise-induced changes in sex hormone levels and lipid peroxidation in athletes participating in the Hawaii Ironman triathlon. Ginsburg-gender and exercise-induced lipid peroxidation.

Journal article Clin Chim Acta · March 2001 BACKGROUND: Exercise reduces the risk of coronary heart disease in men and women but paradoxically, may promote free-radical formation, lipid peroxidation and vascular tissue injury. In this study, we assessed whether exercise-induced oxidative stress simi ... Full text Link to item Cite

Effect of increased body mass index on accuracy of two-dimensional echocardiography for measurement of left ventricular volume, ejection fraction, and mass.

Journal article Am J Cardiol · February 1, 2001 We used 2- and 3-dimensional echocardiography to determine left ventricular volume, mass, and ejection fraction in overweight (body mass index [BMI] > or = 25 kg/m2), obese (BMI > or = 30 kg/m2), and control (BMI < 25 kg/m2) subjects. Compared with corresp ... Full text Link to item Cite

Efficacy of intracoronary or intravenous VEGF165 in a pig model of chronic myocardial ischemia.

Journal article J Am Coll Cardiol · February 2001 OBJECTIVES: We sought to optimize vascular endothelial growth factor (VEGF) treatment for therapeutic angiogenesis in myocardial ischemia, we explored the efficacy of five different regimens. BACKGROUND: Although VEGF165 is one of the most potent pro-angio ... Full text Link to item Cite

Patient motion compensation during transthoracic 3-D echocardiography.

Journal article Ultrasound Med Biol · February 2001 Bulk patient motion during transthoracic 3-D echocardiography (3DE) produces image plane misregistration and errors in left ventricular (LV) volume and ejection fraction (EF). To correct for patient motion, we used a magnetic locating system to track both ... Full text Link to item Cite

The New Ase

Journal article Journal of the American Society of Echocardiography · January 1, 2001 Cite

President's message

Journal article Journal of the American Society of Echocardiography · January 1, 2001 Cite

ASE's staff: A view of ASE's home office

Journal article Journal of the American Society of Echocardiography · January 1, 2001 Full text Cite

Importance of an intact growth hormone/insulin-like growth factor 1 axis for normal post-infarction healing: studies in dwarf rats.

Journal article Endocrinology · January 2001 Treatment with GH attenuates remodeling and improves left ventricular function in the setting of experimental heart failure following coronary ligation. This study was designed to test the hypothesis that an intact GH/insulin-like growth factor 1 (IGF-1) a ... Full text Link to item Cite

Enrollment of women in cardiovascular clinical trials.

Journal article N Engl J Med · December 28, 2000 Link to item Cite

Three-dimensional echocardiographic measurement of left ventricular mass: comparison with magnetic resonance imaging and two-dimensional echocardiographic determinations in man.

Journal article Int J Card Imaging · October 2000 UNLABELLED: This study was performed to compare a novel three-dimensional echocardiography (3DE) system to clinical two-dimensional echocardiography (2DE) and magnetic resonance imaging (MRI) for determination of left ventricular mass (LVM) in humans. LVM ... Full text Link to item Cite

Echocardiographic assessment of cardiac morphology and function in mutant dwarf rats.

Journal article Growth Horm IGF Res · October 2000 Although the mutant dwarf rat has been proposed as a model of growth hormone (GH) deficiency, few studies have addressed its cardiovascular abnormalities. Therefore, the aim of the present study was to investigate cardiac structure and function in mutant d ... Full text Link to item Cite

Accuracy of three-dimensional echocardiography with unrestricted selection of imaging planes for measurement of left ventricular volumes and ejection fraction.

Journal article Am Heart J · September 2000 BACKGROUND: Accurate, reproducible, noninvasive determination of left ventricular (LV) volumes and ejection fraction (EF) is important for clinical assessment, risk stratification, selection of therapy, and serial monitoring of patients with cardiovascular ... Full text Link to item Cite

Multidisciplinary Women's health research: the national centers of excellence in women's health.

Journal article J Womens Health Gend Based Med · September 2000 Contemporary research increasingly needs to consider the value of a multidisciplinary approach in answering critical health questions. The current article outlines the need for multidisciplinary investigations specifically in reference to women's health, a ... Full text Link to item Cite

An evaluation of prosthetic aortic valves using transesophageal echocardiography: the double-envelope technique.

Journal article Anesth Analg · September 2000 UNLABELLED: The conventional continuity equation uses nonsimultaneous measurements of blood flow velocities through the left ventricular outflow tract and across the aortic valve to calculate aortic valve area (AVA). We have noted that both velocities can ... Full text Link to item Cite

Enrollment of women in cardiovascular clinical trials funded by the National Heart, Lung, and Blood Institute.

Journal article N Engl J Med · August 17, 2000 BACKGROUND: With the recognition that certain aspects of cardiovascular disease are specific to sex, the government has sought to ensure that federally funded clinical research yields adequate high-quality information about heart disease in women. METHODS: ... Full text Link to item Cite

Physicians' recommendations to patients for use of antibiotic prophylaxis to prevent endocarditis.

Journal article JAMA · July 5, 2000 CONTEXT: The American Heart Association recommendations for infectious endocarditis (IE) prophylaxis, published in June 1997, sought to improve patient and physician compliance by simplifying the dosing regimen and clarifying endocarditis risk. Adherence t ... Full text Link to item Cite

Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure.

Journal article Circulation · June 20, 2000 BACKGROUND: To determine potential mechanisms of the transition from hypertrophy to very early failure, we examined apoptosis in a model of ascending aortic stenosis (AS) in male FVB/n mice. METHODS AND RESULTS: Compared with age-matched controls, 4-week a ... Full text Link to item Cite

The conserved phosphoinositide 3-kinase pathway determines heart size in mice.

Journal article EMBO J · June 1, 2000 Phosphoinositide 3-kinase (PI3K) has been shown to regulate cell and organ size in Drosophila, but the role of PI3K in vertebrates in vivo is not well understood. To examine the role of PI3K in intact mammalian tissue, we have created and characterized tra ... Full text Link to item Cite

Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.

Journal article Nat Genet · March 2000 Atrioventricular and semilunar valve abnormalities are common birth defects, but how cardiac valvulogenesis is directed remains largely unknown. During studies of genetic interaction between Egfr, encoding the epidermal growth factor receptor, and Ptpn11, ... Full text Link to item Cite

Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy.

Journal article Circulation · February 1, 2000 BACKGROUND: Chronic N(G)-nitro-L-arginine methyl ester (L-NAME), which inhibits nitric oxide synthesis, causes hypertension and would therefore be expected to induce robust cardiac hypertrophy. However, L-NAME has negative metabolic effects on protein synt ... Full text Link to item Cite

Importance of imaging method over imaging modality in noninvasive determination of left ventricular volumes and ejection fraction: assessment by two- and three-dimensional echocardiography and magnetic resonance imaging.

Journal article J Am Coll Cardiol · February 2000 OBJECTIVES: This study sought to determine the concordance between biplane and volumetric echocardiography and magnetic resonance imaging (MRI) strategies and their impact on the classification of patients according to left ventricular (LV) ejection fracti ... Full text Link to item Cite

Abnormal cardiac function in the streptozotocin-induced non-insulin-dependent diabetic rat: noninvasive assessment with doppler echocardiography and contribution of the nitric oxide pathway.

Journal article J Am Coll Cardiol · December 1999 OBJECTIVES: We sought to evaluate in vivo and in vitro left ventricular (LV) geometry and function in streptozotocin-induced diabetic rats and the possible role of the nitric oxide (NO) pathway. BACKGROUND: Diabetes results in cardiac dysfunction; however, ... Full text Link to item Cite

When the body and appendage of the left atrium disagree: "Focal" atrial fibrillation-implications for atrial thrombus formation and risk of thromboembolism.

Journal article J Am Soc Echocardiogr · December 1999 A case is presented of a man who had 5 hours of atrial fibrillation followed by spontaneous conversion and maintained sinus rhythm that persisted as shown by surface electrocardiography. Transesophageal echocardiography performed 24 hours after electrocard ... Link to item Cite

Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity.

Journal article Circulation · November 23, 1999 BACKGROUND: A new model of murine obesity has recently been developed through transgenic ablation of brown adipose tissue that manifests typical metabolic complications of obesity, including insulin resistance and non-insulin-dependent diabetes mellitus. T ... Full text Link to item Cite

Left atrial appendage anatomy and function: short term response to sustained atrial fibrillation.

Journal article Heart · November 1999 OBJECTIVE: To determine whether there is significant atrial or atrial appendage enlargement or functional remodelling as a result of one to two months of sustained atrial fibrillation, a duration similar to that experienced by patients undergoing warfarin ... Full text Link to item Cite

Acute changes in serum lipids and lipoprotein subclasses in triathletes as assessed by proton nuclear magnetic resonance spectroscopy.

Journal article Arterioscler Thromb Vasc Biol · August 1999 Exercise is associated with changes in lipids that may protect against coronary heart disease (CHD). In this study of 28 triathletes, we analyzed acute changes in serum lipid and lipoprotein concentrations after completion of the 1995 World Championship Ha ... Full text Link to item Cite

Intrinsic cardiac muscle function, calcium handling and beta -adrenergic responsiveness is impaired in rats with growth hormone deficiency.

Journal article Growth Horm IGF Res · August 1999 To evaluate whether growth hormone (GH) is required for normal cardiac muscle function, we studied left ventricular papillary muscles of mutant GH-deficient rats. Developed tension normalized by cross-sectional area (DT), intracellular [Ca(2+)](i)(aequorin ... Full text Link to item Cite

Stress echocardiography in women.

Journal article Cardiol Clin · August 1999 The diagnosis of coronary heart disease in women has been thought to be more difficult than in men, owing to the overall lower prevalence and severity of disease in women, as well as more subtle clinical presentations. Exercise electrocardiography is assoc ... Full text Link to item Cite

Effects of propranolol treatment on left ventricular function and intracellular calcium regulation in rats with postinfarction heart failure.

Journal article Br J Pharmacol · August 1999 1. Chronic treatment with beta-adrenergic blocking agents can improve survival in patients with heart failure. The mechanisms underlying the beneficial effects and whether these effects are generalizable to ischaemic heart failure are unresolved. 2. We per ... Full text Link to item Cite

Exaggerated heart rate oscillations during two meditation techniques.

Journal article Int J Cardiol · July 31, 1999 We report extremely prominent heart rate oscillations associated with slow breathing during specific traditional forms of Chinese Chi and Kundalini Yoga meditation techniques in healthy young adults. We applied both spectral analysis and a novel analytic t ... Full text Link to item Cite

Gender differences in molecular remodeling in pressure overload hypertrophy.

Journal article J Am Coll Cardiol · July 1999 OBJECTIVES: The objective of this study was to examine gender differences in left ventricular (LV) function and expression of cardiac genes in response to LV pressure overload due to ascending aortic stenosis in rats. BACKGROUND: Clinical studies have docu ... Full text Link to item Cite

Impact of on-line endocardial border detection on determination of left ventricular volume and ejection fraction by transthoracic 3-dimensional echocardiography.

Journal article J Am Soc Echocardiogr · July 1999 This study was performed to determine whether use of on-line automated border detection (ABD) could reduce data analysis time for 3-dimensional echocardiography (3DE) while maintaining accuracy of 3DE in measures of left ventricular (LV) volumes and ejecti ... Full text Link to item Cite

Cost-effectiveness of diagnostic strategies for patients with chest pain.

Journal article Ann Intern Med · May 4, 1999 BACKGROUND: Many noninvasive tests exist to determine whether patients should undergo coronary angiography. The routine use of coronary angiography without previous noninvasive testing is typically not advocated. OBJECTIVE: To determine the cost-effectiven ... Full text Link to item Cite

Three-dimensional echocardiography improves accuracy and compensates for sonographer inexperience in assessment of left ventricular ejection fraction.

Journal article J Am Soc Echocardiogr · May 1999 This study was performed to determine whether 3-dimensional echocardiography (3DE) with a magnetic tracking system for image plane localization, which unlike standard 2-dimensional echocardiography (2DE), does not require acquisition of specific image plan ... Full text Link to item Cite

Cardiac troponin T and I, echocardiographic [correction of electrocardiographic] wall motion analyses, and ejection fractions in athletes participating in the Hawaii Ironman Triathlon.

Journal article Am J Cardiol · April 1, 1999 Cardiac troponin T (cTnT) and troponin I (cTnI) are highly sensitive and specific for detecting myocardial damage even in the presence of skeletal muscle injury. In this study, we assessed whether ultraendurance exercise induced cardiomyocyte injury using ... Full text Link to item Cite

Hematocrits of triathletes: is monitoring useful?

Journal article Med Sci Sports Exerc · March 1999 PURPOSE: The purpose of this manuscript was to provide a basis for establishing safety cutoffs for hematocrit levels in triathletes and background data for possible future medical control regulations. METHODS: Competitors from three different distance tria ... Full text Link to item Cite

Gender differences in postinfarction left ventricular remodeling.

Journal article Cardiology · 1999 OBJECTIVE: Previous studies suggest that gender affects the adaptive responses of the heart to some forms of cardiac overload. It is unknown whether gender influences left ventricular (LV) remodeling after myocardial infarction (MI). METHODS: We performed ... Full text Link to item Cite

Growth hormone therapy in ischemic heart disease

Journal article Journal of Endocrinological Investigation · December 1, 1998 Although the heart has not been a traditional target of growth hormone (GH), a consistent body of evidence now supports its importance in governing cardiac structure and function, and its possible utility in treating ischemic heart disease. In studies of n ... Cite

Risk for valvular heart disease among users of fenfluramine and dexfenfluramine who underwent echocardiography before use of medication.

Journal article Ann Intern Med · December 1, 1998 BACKGROUND: Because uncontrolled echocardiographic surveys suggested that up to 30% to 38% of users of fenfluramine and dexfenfluramine had valvular disease, these drugs were withdrawn from the market. OBJECTIVE: To determine the risk for new or worsening ... Full text Link to item Cite

Relation between the number of image planes and the accuracy of three-dimensional echocardiography for measuring left ventricular volumes and ejection fraction.

Journal article Am J Cardiol · December 1, 1998 The relation between accuracy of 3-dimensional echocardiography (3DE) in determining left ventricular end-diastolic volume, end-systolic volume, and ejection fraction (compared with magnetic resonance imaging) and the number of component planes used for 3D ... Full text Link to item Cite

Considerations in the Selection of Noninvasive Testing for the Diagnosis of Coronary Artery Disease.

Journal article Cardiol Rev · October 1998 In selecting a noninvasive test for the assessment of patients with suspected coronary artery disease, the clinician must choose from a growing number of methods that use various types of stress and markers of ischemia. Noninvasive testing is most valuable ... Full text Link to item Cite

Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload.

Journal article J Am Coll Cardiol · October 1998 OBJECTIVES: To identify gender differences in left ventricular remodeling, hypertrophy, and function in response to pressure overload due to ascending aortic banding in rats. BACKGROUND: Gender may influence the adaptation to pressure overload, as women wi ... Full text Link to item Cite

Exercise echocardiography or exercise SPECT imaging? A meta-analysis of diagnostic test performance.

Journal article JAMA · September 9, 1998 CONTEXT: Cardiac imaging has advanced rapidly, providing clinicians with several choices for evaluating patients with suspected coronary artery disease, but few studies compare modalities directly. OBJECTIVES: To review the contemporary literature and to c ... Full text Link to item Cite

Outcomes research review.

Journal article J Am Soc Echocardiogr · September 1998 Full text Link to item Cite

Use of heart rate monitors by endurance athletes: lessons from triathletes.

Journal article J Sports Med Phys Fitness · September 1998 Heart rate monitors are commonly used but little is documented about their use. We have reviewed the available literature and supplemented it with data regarding heart rate responses of a large number of highly trained athletes during cycle ergometer and t ... Link to item Cite

The ACC professional life survey: career decisions of women and men in cardiology. A report of the Committee on Women in Cardiology. American College of Cardiology.

Journal article J Am Coll Cardiol · September 1998 OBJECTIVES: This survey was conducted to learn how the career decisions of women and men in cardiology influenced their professional and personal lives. BACKGROUND: Women represent only 5% of practicing adult cardiologists and 10% of trainees. Yet, women a ... Full text Link to item Cite

Insulin-like growth factor-1 but not growth hormone augments mammalian myocardial contractility by sensitizing the myofilament to Ca2+ through a wortmannin-sensitive pathway: studies in rat and ferret isolated muscles.

Journal article Circ Res · July 13, 1998 A growing body of evidence has been accumulated recently suggesting that growth hormone (GH) and insulin-like growth factor-1 (IGF-1) affect cardiac function, but their mechanism(s) of action is unclear. In the present study, GH and IGF-1 were administered ... Full text Link to item Cite

Prolonged exercise alters cardiac chronotropic responsiveness in endurance athletes.

Journal article J Sports Med Phys Fitness · June 1998 OBJECTIVE: To determine whether exhaustive exercise alters cardiac adrenergic chronotropic responsiveness in endurance-trained athletes. METHODS: Fifteen athletes were studied prospectively 2-4 days before and within 3.3 hours after completing the Hawaii I ... Link to item Cite

Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

Journal article Lancet · May 16, 1998 BACKGROUND: There have been many randomised trials of adjuvant tamoxifen among women with early breast cancer, and an updated overview of their results is presented. METHODS: In 1995, information was sought on each woman in any randomised trial that began ... Link to item Cite

Role of routine transthoracic echocardiography in evaluation and management of stroke.

Journal article J Intern Med · April 1998 OBJECTIVE: To determine the value of routine transthoracic echocardiography in patients with cerebral ischemia without known cardiac disease. DESIGN: The literature from 1990 to 1995 was searched and relevant bibliographies from these papers reviewed. Arti ... Full text Link to item Cite

Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia

Journal article American Journal of Physiology - Heart and Circulatory Physiology · March 1, 1998 A number of heparin-binding growth factors, including basic (bFGF) and acidic (aFGF) fibroblast growth factors have been shown to promote angiogenesis in vivo. In this study, we employed a sustained-release polymer extravascular delivery system to evaluate ... Cite

Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia.

Journal article Am J Physiol · March 1998 A number of heparin-binding growth factors, including basic (bFGF) and acidic (aFGF) fibroblast growth factors have been shown to promote angiogenesis in vivo. In this study, we employed a sustained-release polymer extravascular delivery system to evaluate ... Full text Link to item Cite

Cardiac morphology and function in senescent rats: gender-related differences.

Journal article J Am Coll Cardiol · December 1997 OBJECTIVES: We sought to better understand the effects of aging and gender on left ventricular (LV) structure and function. BACKGROUND: Cardiovascular disease in older persons is associated with increased mortality and morbidity. The influence of gender on ... Full text Link to item Cite

A METHOD for image plane re-registration in a transthoracic three-dimensional echocardiography system

Journal article Journal of the American Society of Echocardiography · December 1, 1997 Nearly all three-dimensional echocardiography (3DE) systems described acquire 2D images sequentially, requiring the subject to remain in the same position during data collection. This may be difficult for some patients, and a method for re-registering imag ... Cite

Consequences of growth hormone deficiency on cardiac structure, function, and beta-adrenergic pathway: studies in mutant dwarf rats.

Journal article Endocrinology · December 1997 To evaluate GH's role in cardiac physiology and its interrelationship with the beta-adrenergic system, we studied GH-deficient dwarf (dw/dw) and control rats in 4 groups of 20 each: dwarf group receiving placebo, dwarf-GH group receiving 2 mg/kg GH, dwarf- ... Full text Link to item Cite

Left ventricular hypertrophy in athletes.

Journal article Am J Cardiol · November 15, 1997 Left ventricular wall thickness >1.3 cm, septal-to-posterior wall ratios > 1.5, diastolic left ventricular size >6.0 cm, and eccentric or concentric remodeling are rare in athletes. Values outside of these cutoffs in an athlete of any age probably represen ... Full text Link to item Cite

Acquired dynamic left ventricular outflow tract obstruction complicating acute anterior myocardial infarction: serial echocardiographic and clinical evaluation.

Journal article J Am Soc Echocardiogr · September 1997 We describe three cases of dynamic outflow obstruction complicating acute anterior myocardial infarction. Serial echocardiography suggests the intraventricular gradient results from basal hyperkinesis, the latter being a reciprocal response to the apical w ... Full text Link to item Cite

Echocardiography for the assessment of myocardial viability.

Journal article J Am Soc Echocardiogr · September 1997 The identification of viable myocardium in the setting of acute myocardial infarction or chronic coronary artery disease with reduced left ventricular function has important prognostic and therapeutic implications. Many noninvasive methods have been used t ... Full text Link to item Cite

Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters.

Journal article J Pharmacol Exp Ther · July 1997 Recently, a number of growth factors including basic fibroblast growth factor (bFGF) have been shown to promote angiogenesis in vivo. In this study, we evaluated dose-dependent effect of bFGF administration in the setting of chronic myocardial ischemia. A ... Link to item Cite

Growth hormone attenuates early left ventricular remodeling and improves cardiac function in rats with large myocardial infarction.

Journal article J Am Coll Cardiol · April 1997 OBJECTIVES: We sought to investigate the cardiac effects of growth hormone (GH) administration during the early phase of pathologic remodeling in a rat model of large myocardial infarction (MI). BACKGROUND: Recent evidence suggests that exogenous administr ... Full text Link to item Cite

Angiotensin AT1 receptor inhibition. Effects on hypertrophic remodeling and ACE expression in rats with pressure-overload hypertrophy due to ascending aortic stenosis.

Journal article Circulation · March 18, 1997 BACKGROUND: We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)-receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with a ... Full text Link to item Cite

Ovarian ablation in early breast cancer: overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group.

Journal article Lancet · November 2, 1996 BACKGROUND: Among women with early breast cancer, the effects of ovarian ablation on recurrence and death have been assessed by several randomised trials that now have long follow-up. In this report, the Early Breast Cancer Trialists' Collaborative Group p ... Link to item Cite

Evaluation of left atrial appendage anatomy and function in recent-onset atrial fibrillation by transesophageal echocardiography.

Journal article Am J Cardiol · October 1, 1996 Data regarding left atrial (LA) and LA appendage anatomy and function among patients with newly recognized atrial fibrillation (AF) who have not received long-term warfarin are currently unknown. To identify echocardiographic indexes which characterize tho ... Full text Link to item Cite

Chest pain in women.

Journal article N Engl J Med · September 12, 1996 Full text Link to item Cite

Why cardiologists should be interested in estrogen.

Journal article Am J Cardiol · September 1, 1996 Full text Link to item Cite

Long-term captopril treatment improves diastolic filling more than systolic performance in rats with large myocardial infarction.

Journal article J Am Coll Cardiol · September 1996 OBJECTIVES: This study sought to determine the effects of long-term angiotensin-converting enzyme (ACE) inhibition on left ventricular (LV) diastolic filling in postinfarction heart failure. BACKGROUND: Long-term treatment with ACE inhibitors is beneficial ... Full text Link to item Cite

Cardiac risk of noncardiac surgery in patients with asymmetric septal hypertrophy.

Journal article Anesthesiology · August 1996 BACKGROUND: Many data are available regarding cardiac risk in patients with coronary artery disease undergoing noncardiac surgery, but few data are available regarding risk for patients with hypertrophic cardiomyopathy and asymmetric septal hypertrophy. ME ... Full text Link to item Cite

Exogenously administered growth hormone and insulin-like growth factor-I alter intracellular Ca2+ handling and enhance cardiac performance. In vitro evaluation in the isolated isovolumic buffer-perfused rat heart.

Journal article Circ Res · August 1996 It has been proposed that chronic treatment with growth hormone (GH) or insulin-like growth factor-I (IGF-I) in the rat may enhance cardiac function in vivo. To confirm these findings and elucidate the mechanisms by which cardiac function is modulated, we ... Full text Link to item Cite

Effects of a single bout of ultraendurance exercise on lipid levels and susceptibility of lipids to peroxidation in triathletes.

Journal article JAMA · July 17, 1996 OBJECTIVE: To determine the effects of a single bout of ultraendurance exercise, as a model for physiologic stress, on lipid and lipoprotein levels, and oxidative susceptibility of lipids in highly trained athletes. DESIGN: Observational trial. POPULATION ... Link to item Cite

Restrictive left ventricular filling patterns in very old patients with congestive heart failure: clinical correlates and prognostic significance.

Journal article J Am Geriatr Soc · June 1996 OBJECTIVES: In certain younger patients with congestive heart failure (CHF), Doppler/echocardiography has identified a "restrictive" pattern of early diastolic ventricular filling characterized by very rapid early filling and a steep deceleration slope. We ... Full text Link to item Cite

The evaluation of chest pain in women.

Journal article N Engl J Med · May 16, 1996 Full text Link to item Cite

Chronic growth hormone treatment in normal rats reduces post-prandial skeletal muscle plasma membrane GLUT1 content, but not glucose transport or GLUT4 expression and localization.

Journal article Biochem J · May 1, 1996 Whether skeletal muscle glucose transport system is impaired in the basal, post-prandial state during chronic growth hormone treatment is unknown. The current study was designed to determine whether 4 weeks of human growth hormone (hGH) treatment (3.5 mg/k ... Full text Link to item Cite

Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation.

Journal article Circulation · February 15, 1996 BACKGROUND: Despite their increasing clinical use and recent evidence that growth hormone (GH) and insulin-like growth factor-1 (IGF-1) target the heart, there has been no systematic investigation of the effects of GH and IGF-1 on the cardiovascular system ... Full text Link to item Cite

Prolonged exercise alters beta-adrenergic responsiveness in healthy sedentary humans.

Journal article J Appl Physiol (1985) · February 1996 To examine whether beta-adrenergic desensitization occurs after prolonged exercise, echocardiograms, heart rate responses to isoproterenol, plasma catecholamines, and circulating lymphocyte beta-adrenergic receptors were examined in 10 sedentary normal sub ... Full text Link to item Cite

Cardiac tamponade in association with an atrial septal defect: echocardiographic Doppler and hemodynamic observations.

Journal article J Am Soc Echocardiogr · 1996 We describe a case of cardiac tamponade in association with an atrial septal defect, in which pulsus paradoxus and respiratory variations in right and left ventricular filling were absent. Doppler echocardiography of the flow across the atrial septal defec ... Full text Link to item Cite

Accuracy of transesophageal echocardiography for identifying left atrial thrombi. A prospective, intraoperative study.

Journal article Ann Intern Med · December 1, 1995 OBJECTIVE: To determine the ability of transesophageal echocardiography to accurately identify or exclude left atrial thrombi. DESIGN: Prospective cohort study. SETTING: University hospital. PATIENTS: 231 consecutive patients having transesophageal echocar ... Full text Link to item Cite

Prevalence of residual left atrial thrombi among patients with acute thromboembolism and newly recognized atrial fibrillation.

Journal article Arch Intern Med · November 13, 1995 BACKGROUND: Thromboembolism related to atrial fibrillation (AF) is a major cause of morbidity and mortality. Patients with acute thromboembolism and AF are at high risk for early recurrent events. OBJECTIVE: To determine the prevalence of left atrial throm ... Link to item Cite

Optimal determination of right ventricular filling dynamics in systemic hypertension.

Journal article Am Heart J · November 1995 To determine the optimal method of normalizing peak filling rate (PFR) determinations and apply it to the assessment of right ventricular (RV) and left ventricular (LV) filling characteristics and their interactions, 41 subjects with hypertension and 40 ma ... Full text Link to item Cite

Treatment with growth hormone and IGF-I in growing rats increases bone mineral content but not bone mineral density.

Journal article J Bone Miner Res · September 1995 Human growth hormone (hGH) and insulin-like growth factor I (IGF-I) both stimulate bone formation and have been proposed as therapeutic agents for osteoporosis. We examined the effect of hGH and IGF-I alone and in combination on bone size, bone mineral con ... Full text Link to item Cite

Multiplane transesophageal echocardiographic assessment of left atrial appendage anatomy and function.

Journal article Am J Cardiol · September 1, 1995 Anatomic indexes of the LAA are dependent on the plane in which the appendage is viewed. Greater LAA neck width and cross-sectional area are observed at 135 degrees than at 45 degrees or 90 degrees, consistent with the characteristic 3-dimensional ungular ... Full text Link to item Cite

Cardioversion of nonrheumatic atrial fibrillation. Reduced thromboembolic complications with 4 weeks of precardioversion anticoagulation are related to atrial thrombus resolution.

Journal article Circulation · July 15, 1995 BACKGROUND: The use of warfarin anticoagulation for several weeks before cardioversion results in a 90% reduction in the incidence of cardioversion-related thromboembolism. The mechanism of this benefit, however, is unknown; it has been widely attributed t ... Full text Link to item Cite

Gender differences in left ventricle geometry and function in patients undergoing balloon dilatation of the aortic valve for isolated aortic stenosis. NHLBI Balloon Valvuloplasty Registry.

Journal article Br Heart J · June 1995 BACKGROUND: Gender differences in cardiac size have been described in normal humans and animals and in response to pressure overload. To examine the influence of gender on the left ventricular response to pressure overload, clinical, haemodynamic, and echo ... Full text Link to item Cite

Serial echocardiographic-Doppler assessment of left ventricular geometry and function in rats with pressure-overload hypertrophy. Chronic angiotensin-converting enzyme inhibition attenuates the transition to heart failure.

Journal article Circulation · May 15, 1995 BACKGROUND: Although chronic pressure overload may progress to left ventricular (LV) failure, the pathophysiology of this transition is not well understood. In addition, the effects of chronic angiotensin-converting enzyme (ACE) inhibition on this transiti ... Full text Link to item Cite

Transesophageal echocardiographically facilitated early cardioversion from atrial fibrillation using short-term anticoagulation: final results of a prospective 4.5-year study.

Journal article J Am Coll Cardiol · May 1995 OBJECTIVES: We sought to validate the safety of transesophageal echocardiographically guided early cardioversion in conjunction with short-term anticoagulation as a strategy for guiding early cardioversion in hospitalized patients with atrial fibrillation. ... Full text Link to item Cite

Applied physiology of triathlon.

Journal article Sports Med · April 1995 The triathlon is a 3-event endurance sport in which athletes compete sequentially in swimming, cycling and running. The primary determinant of success is the ability to sustain a high rate of energy expenditure for prolonged periods of time. Exercise train ... Full text Link to item Cite

Reply

Journal article Journal of the American College of Cardiology · January 1, 1995 Full text Cite

Subvalvular Aortic Membrane Masquerading as Valvular Aortic Stenosis

Journal article Echocardiography · January 1, 1995 Discrete subvalvular aortic membrane is an unusual cause of left ventricular outflow tract obstruction. While commonly presenting during childhood, one quarter of the individuals are asymptomatic in childhood but remain vulnerable to progressive outflow tr ... Full text Cite

Fluid and electrolyte status in athletes receiving medical care at an ultradistance triathlon.

Journal article Clin J Sport Med · 1995 Thirty competitors in the Hawaii Ironman Triathlon were prospectively studied to determine whether fluid and electrolyte disturbances were causes for seeking race-day medical care. Athlete weights were significantly (p < 0.0001) decreased during the race, ... Full text Link to item Cite

Intracardiac angiotensin-converting enzyme inhibition improves diastolic function in patients with left ventricular hypertrophy due to aortic stenosis.

Journal article Circulation · December 1994 BACKGROUND: Cardiac hypertrophy is associated with elevated intracardiac angiotensin-converting enzyme activity, which may contribute to diastolic dysfunction. METHODS AND RESULTS: We infused enalaprilat (0.05 mg/min) for 15 minutes into the left coronary ... Full text Link to item Cite

Thromboembolism after negative TEE.

Journal article Circulation · December 1994 Full text Link to item Cite

Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis.

Journal article Circulation · September 1994 BACKGROUND: We tested the hypotheses that long-term administration of the angiotensin-converting enzyme (ACE) inhibitor fosinopril will regress hypertrophy, modify the transition to heart failure, and prolong survival in rats with chronic left ventricular ... Full text Link to item Cite

Clinical utility of transthoracic two-dimensional and Doppler echocardiography.

Journal article J Am Coll Cardiol · July 1994 OBJECTIVES: The purpose of this study was to determine the value of contemporary echocardiography for patient diagnosis and management in clinical practice. BACKGROUND: Although the use of echocardiography is growing rapidly, there is little information ab ... Full text Link to item Cite

Impaired left atrial mechanical function after cardioversion: relation to the duration of atrial fibrillation.

Journal article J Am Coll Cardiol · June 1994 OBJECTIVES: We hypothesized that the time course of the recovery of atrial systolic function may be related to the duration of atrial fibrillation before cardioversion and sought to study noninvasively the recovery of left atrial mechanical function utiliz ... Full text Link to item Cite

In vivo assessment of LV mass in mice using high-frequency cardiac ultrasound: necropsy validation.

Journal article Am J Physiol · April 1994 Left ventricular (LV) mass is an important descriptor of cardiac status that increases with normal aging and may be affected by a variety of disease processes. There are currently limited noninvasive techniques that permit accurate determination of in vivo ... Full text Link to item Cite

Cocaine-induced transmural myocardial infarction in a Yorkshire swine with normal coronary arteries: Evidence for microvascular and/or epicardial coronary artery spasm.

Journal article Cardiovasc Pathol · 1994 Cocaine-induced myocardial infarction with normal coronary arteries is well documented in humans. The exact mechanism of action remains speculative. We report one case of cocaine-induced myocardial infarction with normal coronaries in one swine. Systemic h ... Full text Link to item Cite

Serial echocardiographic assessment of left ventricular geometry and function after large myocardial infarction in the rat.

Journal article Circulation · January 1994 BACKGROUND: The development of heart failure after acute myocardial infarction (MI) may be related to alterations of left ventricular (LV) structure and function. Pathological LV remodeling may exacerbate systolic and diastolic dysfunction because increase ... Full text Link to item Cite

Echocardiographically detected myocardial infarction in the mouse.

Journal article Lab Anim Sci · December 1993 The ability to obtain high-quality echocardiographic images of the heart in a small mammal such as the mouse would enable investigators to noninvasively and serially assess cardiac function and identify focal lesions. We recently had the opportunity to per ... Link to item Cite

Atrial ejection force: a noninvasive assessment of atrial systolic function.

Journal article J Am Coll Cardiol · July 1993 OBJECTIVES: The purpose of this study was to define atrial ejection force and to develop a method for its noninvasive measurement from echocardiographic data. BACKGROUND: Assessment of diastolic function through measurement of the components of ventricular ... Full text Link to item Cite

The influence of age on endocrine responses to ultraendurance stress.

Journal article J Gerontol · July 1993 BACKGROUND: Aging produces significant changes in the human endocrine system. This study was designed to determine if elderly and younger individuals differ in various endocrine measures before and after ultraendurance stress. METHODS: Sixteen young and 19 ... Full text Link to item Cite

Cardioversion from atrial fibrillation without prolonged anticoagulation with use of transesophageal echocardiography to exclude the presence of atrial thrombi.

Journal article N Engl J Med · March 18, 1993 BACKGROUND: Because atrial thrombi are poorly detected by conventional noninvasive techniques such as transthoracic echocardiography, patients with prolonged atrial fibrillation usually receive several weeks of oral anticoagulation therapy before cardiover ... Full text Link to item Cite

Reperfusion and revascularization strategies for coronary artery disease in women.

Journal article JAMA · October 14, 1992 OBJECTIVE: One third of all deaths in women in the United States each year are attributable to coronary heart disease. Gender differences exist in the course and management of patients with coronary heart disease. Few randomized trials have been conducted ... Link to item Cite

Exercise and atherosclerotic heart disease in women.

Journal article Med Sci Sports Exerc · June 1992 Link to item Cite

Selection of patients for coronary angiography and coronary revascularization early after myocardial infarction: is there evidence for a gender bias?

Journal article Ann Intern Med · May 15, 1992 OBJECTIVE: To determine whether a gender bias exists in the selection of patients for diagnostic and therapeutic cardiovascular procedures early after myocardial infarction. DESIGN: A retrospective cohort study. SETTING: A community-based tertiary care tea ... Full text Link to item Cite

Aging and physical activity determine cardiac structure and function in the older athlete.

Journal article J Appl Physiol (1985) · May 1992 To evaluate the effects of age and physical activity on cardiac structure and function, 45 ultra-endurance athletes were compared with 24 sedentary control subjects. Two-dimensionally guided M-mode echocardiograms and pulsed Doppler studies of left ventric ... Full text Link to item Cite

Two-dimensional and Doppler echocardiographic determinants of the natural history of mitral valve narrowing in patients with rheumatic mitral stenosis: implications for follow-up.

Journal article J Am Coll Cardiol · April 1992 Fifty patients with rheumatic mitral stenosis were studied with serial two-dimensional and Doppler echocardiography to determine the natural history of changes in mitral valve area and its relation to transmitral gradients and mitral valve morphology. Over ... Full text Link to item Cite

Left ventricular function is not impaired in weight-lifters who use anabolic steroids.

Journal article J Am Coll Cardiol · February 1992 Recent reports suggest that anabolic steroid use might deleteriously affect left ventricular function. To examine this possibility, the present study measured left ventricular size and function with use of Doppler echocardiographic techniques in 23 weight ... Full text Link to item Cite

Use of transoesophageal echocardiography to detect left atrial thrombi before percutaneous balloon dilatation of the mitral valve: a prospective study.

Journal article Br Heart J · February 1992 OBJECTIVE: Systemic emboli related to atrial thrombi are a well known complication of percutaneous balloon dilatation of the mitral valve. The presence of left atrial thrombi therefore, is believed to be a contraindication to balloon dilatation. The purpos ... Full text Link to item Cite

Exercise and atherosclerotic heart disease in women

Journal article Medicine and Science in Sports and Exercise · 1992 Cite

Creatinine kinase kinetics studied by phosphorus-31 nuclear magnetic resonance in a canine model of chronic hypertension-induced cardiac hypertrophy.

Journal article J Am Coll Cardiol · January 1992 To determine whether cardiac hypertrophy secondary to chronic renovascular hypertension is associated with altered in vivo myocardial metabolism, phosphorus-31 nuclear magnetic resonance saturation transfer techniques were used to study creatine kinase (CK ... Full text Link to item Cite

Cardiac amyloidosis

Journal article New England Journal of Medicine · January 1, 1992 Full text Cite

Echo/Doppler and hemodynamic correlates of vasodilator responsiveness in primary pulmonary hypertension.

Journal article Chest · May 1991 To determine correlates of acute vasodilator responsiveness in primary pulmonary hypertension, we retrospectively studied 25 patients, comparing 41 resting echo/Doppler and nine resting catheterization variables with the maximal reduction in pulmonary vasc ... Full text Link to item Cite

Hypertrophy, fibrosis and diastolic dysfunction in early canine experimental hypertension.

Journal article J Am Coll Cardiol · February 1991 To examine the relations among hypertrophy, fibrosis and diastolic performance in early experimental hypertension, 18 control dogs and 12 dogs with experimental left ventricular hypertrophy were studied. Diastolic function was impaired in dogs with left ve ... Full text Link to item Cite

Regional wall motion abnormalities after prolonged exercise in the normal left ventricle.

Journal article Circulation · December 1990 To determine whether regional wall motion abnormalities exist or contribute to left ventricular dysfunction, we obtained two-dimensional echocardiograms in 12 athletes before (baseline), immediately after (race finish), and 1 day after (recovery) the Hawai ... Full text Link to item Cite

Effects of sample volume location, imaging view, heart rate and age on tricuspid velocimetry in normal subjects.

Journal article Am J Cardiol · April 15, 1990 The effects of imaging view and sample volume location on tricuspid velocimetry and of heart rate and aging on mitral and tricuspid inflow were evaluated in 41 normal subjects aged 20 to 76 years. Pulsed Doppler recordings were obtained in the parasternal ... Full text Link to item Cite

Gender and heart disease.

Journal article Hosp Pract (Off Ed) · February 28, 1990 Link to item Cite

Evaluation of diastolic function by echocardiography

Journal article American Journal of Cardiac Imaging · January 1, 1990 Cite

Different effects of prolonged exercise on the right and left ventricles.

Journal article J Am Coll Cardiol · January 1990 To examine the functional consequences of the greater increase in right ventricular work with exercise, the effects of prolonged exercise on the right and left heart chambers were compared in 41 athletes before, at the finish (13 min) and after recovery (2 ... Full text Link to item Cite

Iron Status in Ultraendurance Triathletes.

Journal article Phys Sportsmed · December 1989 In brief: Using several hematologic indexes, researchers examined the iron status of 50 ultraendurance athletes participating in the 1988 Ironman Triathlon in Hawaii. Fifteen (30%) of the 50 triathletes had at least one suboptimal iron index: Two exhibited ... Full text Link to item Cite

Lactate, oxygen uptake, and cycling performance in triathletes.

Journal article Int J Sports Med · December 1989 To assess the relationship of exercise test variables to each other and to bike race times in an ultra-distance triathlon, we studied 24 participants (14 men, 10 women) in the 1985 Hawaii Ironman Triathlon, using a graded, maximal cycle ergometer test with ... Full text Link to item Cite

Cardiac considerations in the triathlete.

Journal article Med Sci Sports Exerc · October 1989 The cardiac adaptation to exercise training produces a variety of adaptations in cardiac size, shape, and function. To further define these changes and to investigate the effects of maximal conditioning, we studied ultraendurance triathletes training for t ... Link to item Cite

Applied physiology of a triathlon.

Journal article Sports Med · October 1989 The triathlon is an endurance contest in which contestants must compete in 3 consecutive events, usually swimming, cycling and running. Success in a triathlon depends upon the ability of the triathlete to perform each of the sequential events at optimal pa ... Full text Link to item Cite

Assessment of anatomy and cardiac function by Doppler echocardiography.

Journal article Cardiol Clin · August 1989 In this article, we have reviewed the impact of the new technique of Doppler ultrasound upon the assessment of aortic stenosis, aortic regurgitation, and diastolic left ventricular function. It is a powerful new technique that greatly extends our ability t ... Link to item Cite

Two-dimensional and Doppler-echocardiographic and cardiac catheterization correlates of survival in primary pulmonary hypertension.

Journal article Circulation · August 1989 To determine correlates of survival in primary pulmonary hypertension, we compared 41 echocardiography-Doppler and nine catheterization parameters with outcome in 26 patients. Mean follow-up was 19.7 months in survivors; mean survival was 4.8 months in 16 ... Full text Link to item Cite

Prevalence of multivalvular regurgitation in athletes.

Journal article Am J Cardiol · July 15, 1989 To assess the effects of exercise training on the prevalence of valvular regurgitation, 2-dimensional echocardiography and Doppler flow mapping were performed in 45 athletes and 26 sedentary control subjects of similar age and sex. Mitral, tricuspid, aorti ... Full text Link to item Cite

Endurance exercise in the presence of heart disease.

Journal article Chest · March 1989 Although patients with heart disease have successfully completed marathon runs, the immediate cardiac effects of similar and greater distance endurance exercise competition are unknown. Two such cases are presented, demonstrating that vigorous exercise and ... Full text Link to item Cite

Alterations in diastolic function in response to progressive left ventricular hypertrophy.

Journal article J Am Coll Cardiol · February 1989 To examine the time course of the functional consequences of progressive left ventricular hypertrophy, diastolic left ventricular inflow and wall thinning variables were analyzed in 13 dogs before and 2, 4, 8 and 12 weeks after creation of perinephritic hy ... Full text Link to item Cite

Left ventricular shape, afterload and survival in idiopathic dilated cardiomyopathy.

Journal article J Am Coll Cardiol · February 1989 Because idiopathic dilated cardiomyopathy is characterized by elevated wall stress and a more spherical left ventricle, the relations among shape, afterload and survival were examined. Thirty-six patients with cardiomyopathy were prospectively studied by t ... Full text Link to item Cite

Introduction: The ultraendurance triathlete: Physiologic and medical considerations

Journal article Medicine and Science in Sports and Exercise · January 1, 1989 Triathlons (races involving consecutive swimming, bicycling, and running) attract well over 1.5 million participants annually. These races may involve from 30 min to 36 h of continuous exercise, usually in warm or hot environments. Medical and physiologic ... Cite

Introduction: The ultraendurance triathlete: Physiologic and medical considerations

Journal article Medicine and Science in Sports and Exercise · 1989 Triathlons (races involving consecutive swimming, bicycling, and running) attract well over 1.5 million participants annually. These races may involve from 30 min to 36 h of continuous exercise, usually in warm or hot environments. Medical and physiologic ... Cite

Cardiac considerations in the triathlete

Journal article Medicine and Science in Sports and Exercise · 1989 The cardiac adaptation to exercise training produces a variety of adaptations in cardiac size, shape, and function. To further define these changes and to investigate the effects of maximal conditioning, we studied ultraendurance triathletes training for t ... Cite

Altered inotropic state obscures hypertrophy-induced diastolic dysfunction

Journal article Journal of Applied Cardiology · January 1, 1989 Cite

Focal posterior left atrial turbulence as a sign of pulmonary venous obstruction

Journal article Journal of Cardiovascular Technology · January 1, 1989 Two-dimensional and Doppler ultrasonography of a patient with pulmonary hypertension due to histoplasmosis-induced fibrosis mediastinitis with resultant pulmonary venous obstruction revealed focal posterior left atrial turbulence, as well as evidence of ri ... Cite

Rheumatic heart disease and other valvular disorders in women.

Journal article Cardiovasc Clin · 1989 This chapter has surveyed the known differences between men and women with respect to rheumatic and valvular heart disease. The gender disparities noted are important aspects of the pathophysiology of each of the diseases discussed, such that any complete ... Link to item Cite

Skeletal muscle grafts applied to the heart. A word of caution.

Journal article Circulation · November 1988 Latissimus dorsi pedicle grafts (LDPGs) were wrapped around the heart in eight dogs. In four dogs, the LDPGs were stimulated chronically; the remaining four dogs served as unstimulated controls. Right-sided cardiac filling pressures were normal in all dogs ... Link to item Cite

Electrocardiographic diagnosis of exercise-induced left ventricular hypertrophy.

Journal article Am Heart J · September 1988 To assess the prevalence of physiologic left ventricular hypertrophy and the usefulness of ECG criteria for its diagnosis, we compared ECGs and M-mode echocardiograms from 44 ultraendurance athletes and 20 similarly aged sedentary control subjects. Left ve ... Full text Link to item Cite

Hemolysis during triathlon races: its relation to race distance.

Journal article Med Sci Sports Exerc · June 1988 Ninety-five triathletes were evaluated for evidence of hemolysis during triathlon races of two different distances. Thirty competitors (11 males, 19 females) were studied before and after the United States Triathlon Series (USTS) National Championship Race ... Full text Link to item Cite

Antianginal effects of intravenous nitroglycerin over 24 hours.

Journal article Circulation · June 1988 To determine the constancy of hemodynamic and antianginal effects of the constant infusion of intravenous nitroglycerin (NTG) and their relationship to infusion rate and plasma NTG concentration, we administered maximal tolerated doses of intravenous NTG ( ... Full text Link to item Cite

Exercise training for competitive tennis.

Journal article Clin Sports Med · April 1988 This article reviews the muscle physiology underlying various forms of activity, as well as the adaptive responses induced by specific forms of training, and thus provides a rational basis for the design of a training program for competitive tennis. ... Link to item Cite

Echocardiographic visualization of coronary artery anatomy in the adult.

Journal article J Am Coll Cardiol · March 1988 In the light of technologic advances and the development of new imaging planes, the feasibility of two-dimensional echocardiographic visualization of coronary artery anatomy was reevaluated in the adult. Thirty-five subjects were studied using an ultrasono ... Full text Link to item Cite

Clinical comparison of St. Jude and porcine mitral valve prostheses.

Journal article J Cardiovasc Surg (Torino) · 1988 One hundred and six consecutive patients who had mitral valve replacement with either a St. Jude or porcine heterograft prosthesis were prospectively studied. The 2 groups are similar with respect to 67 clinical and operative factors and allow comparison o ... Link to item Cite

Cardiac fatigue after prolonged exercise.

Journal article Circulation · December 1987 To determine the effects of prolonged exercise on systolic and diastolic left ventricular function, we studied 21 athletes before, at the finish (within 11 +/- 5 min), and during recovery (28 +/- 9 hr) after the Hawaii Ironman Triathlon (2.4 mile swim, 112 ... Full text Link to item Cite

Variable responses of mitral valve motion and flow in systemic hypertension and in idiopathic dilated cardiomyopathy.

Journal article Am J Cardiol · August 1, 1987 The relation between transmitral flow and diastolic mitral valve motion were examined in 17 normal persons, 14 patients with hypertension and 12 patients with idiopathic dilated cardiomyopathy. M-mode echograms were analyzed for early and late diastolic mi ... Full text Link to item Cite

Unreliability of hemodynamic indexes of left ventricular size during cardiac surgery.

Journal article Ann Thorac Surg · July 1987 Pulmonary artery diastolic (PADP) and wedge pressures (PAWP) and left ventricular end-diastolic pressure (LVEDP) are commonly used to estimate left ventricular (LV) preload. To assess the ability of hemodynamic indexes of preload to estimate anatomical pre ... Full text Link to item Cite

Early postoperative changes in left ventricular chamber size, architecture, and function in aortic stenosis and aortic regurgitation and their relation to intraoperative changes in afterload: a prospective two-dimensional echocardiographic study.

Journal article Circulation · July 1987 We prospectively studied 16 patients with isolated aortic stenosis and eight with isolated aortic regurgitation undergoing aortic valve replacement, using two-dimensional echocardiography preoperatively, intraoperatively, and 41 +/- 7 days postoperatively ... Full text Link to item Cite

Contribution of afterload, hypertrophy and geometry to left ventricular ejection fraction in aortic valve stenosis, pure aortic regurgitation and idiopathic dilated cardiomyopathy.

Journal article Am J Cardiol · June 1, 1987 To investigate the relation of left ventricular (LV) afterload, hypertrophy, geometry and systolic pump function, 17 normal persons, 24 patients with aortic stenosis (AS), 20 with aortic regurgitation (AR) and 15 with idiopathic dilated cardiomyopathy (DC) ... Full text Link to item Cite

Comparison of echocardiographic methods for assessment of left ventricular shortening and wall stress.

Journal article J Am Coll Cardiol · April 1987 M-mode echocardiographic measurement of left ventricular fractional shortening and meridional wall stress has been used extensively alone and in combination to describe left ventricular systolic function. To determine whether the improved dimensional infor ... Full text Link to item Cite

Experimental congestive heart failure produced by rapid ventricular pacing in the dog: cardiac effects.

Journal article Circulation · April 1987 Chronic rapid ventricular pacing in the dog reportedly produces a useful preparation of low-output heart failure. However, little information is available regarding cardiac changes in this preparation. Accordingly, we evaluated the effects of both short-te ... Full text Link to item Cite

The ultraendurance triathlete: a physiological profile.

Journal article Med Sci Sports Exerc · February 1987 To better characterize the athletes who participate in ultraendurance triathlons, 14 triathletes in training for the Hawaii IRONMAN triathlon were studied. A physical and physiological profile was developed from anthropometric measurements and oxygen uptak ... Link to item Cite

Cardiovascular responses to prolonged cycling and running

Journal article Annals of Sports Medicine · January 1, 1987 Cite

Noninvasive evaluation of exercise-induced changes in the heart

Journal article Annals of Sports Medicine · January 1, 1987 Cite

Correlation of cine MR imaging with two-dimensional pulsed Doppler echocardiography in valvular insufficiency.

Journal article J Comput Assist Tomogr · 1987 Eight adults with known valvular insufficiency were studied with cine magnetic resonance (MR) imaging. Our cine MR uses cardiac synchronization of a rapid small flip angle pulse sequence on a 1.5 T MR system. Eleven regurgitant lesions (including aortic, m ... Full text Link to item Cite

Gender, cardiology, and optimal medical care.

Journal article Circulation · November 1986 Full text Link to item Cite

Left ventricular structure and function by echocardiography in ultraendurance athletes.

Journal article Am J Cardiol · October 1, 1986 To determine left ventricular (LV) structural and functional changes induced by ultraendurance exercise training, M-mode LV echograms and Doppler recordings of LV inflow velocity in 26 triathletes and 17 normal subjects were studied. All triathletes traine ... Full text Link to item Cite

Intraoperative assessment of left ventricular heterogeneity.

Journal article Am Heart J · August 1986 To evaluate regional differences in thickness and systolic function of human myocardium perfused by angiographically normal coronary arteries in valvular and ischemic heart disease, we performed intraoperative epicardial M-mode mapping of ventriculographic ... Full text Link to item Cite

Estimation of wall stress and left ventricular mass by noninvasive techniques and clinical implications.

Journal article Cardiovasc Clin · 1986 Left ventricular mass and wall stress are easily calculated using routinely available imaging modalities. Consideration of these parameters provides important contributions to the evaluation and treatment of many forms of heart disease. The newer technique ... Link to item Cite

Relative wall thickness analysis by two-dimensional echocardiography.

Journal article Am Heart J · November 1985 M-mode echocardiographic relative wall thickness (RWT) has been used extensively as an index of left ventricular hypertrophy. To determine whether the more extensive tomographic sampling and enhanced spatial orientation provided by two-dimensional echocard ... Full text Link to item Cite

Effects of reduced left ventricular mass on chamber architecture, load, and function: a study of anorexia nervosa.

Journal article Circulation · November 1985 We investigated the effects of reduction in left ventricular mass on cavity geometry, afterload, pump function, and exercise performance in 17 patients with anorexia nervosa and in 10 age-and sex-matched normal subjects. Left ventricular mass index determi ... Full text Link to item Cite

Clinical correlates of atrial tachyarrhythmias after valve replacement for aortic stenosis.

Journal article Circulation · September 1985 One hundred eighteen consecutive patients undergoing valve replacement for aortic stenosis were analyzed to determine the incidence of and predisposing factors to postoperative atrial tachyarrhythmias. Univariate and multivariate analyses were performed on ... Link to item Cite

Clinical comparison of St. Jude and porcine aortic valve prostheses.

Journal article Circulation · September 1985 One hundred eighty-seven consecutive patients who had aortic valve replacement with either a St. Jude or porcine heterograft prosthesis were studied prospectively. The two groups were similar with respect to 67 clinical and operative factors, which allowed ... Link to item Cite

Extreme hypercalcemia and electrocardiographic changes.

Journal article Am J Cardiol · September 1, 1984 Full text Link to item Cite

Worldwide Trends in Multi-arterial Coronary Artery Bypass Grafting Surgery 2004-2014: A Tale of 2 Continents.

Journal article Semin Thorac Cardiovasc Surg Recent evidence shows that multi-arterial coronary artery bypass grafting (MABG) based on bilateral internal thoracic (BITA) or left internal thoracic (LITA) and radial artery (RA) improves long-term outcomes compared with single arterial coronary artery b ... Full text Link to item Cite