Dhavalkumar Dhirajlal Patel

Journal article J Biol Chem · May 31, 2002 Featured Publication Fractalkine is a unique CX(3)C chemokine/mucin hybrid molecule that functions like selectins in inducing the capture of receptor-expressing cells. Because of the importance of tyrosine sulfation for ligand binding of the selectin ligand PSGL1, we tested th ... Full text Link to item Cite

Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice.

Journal article Proc Natl Acad Sci U S A · May 28, 2002 Featured Publication Lymphocyte chemotaxis is a complex process by which cells move within tissues and across barriers such as vascular endothelium and is usually stimulated by chemokines such as stromal cell-derived factor-1 (CXCL12) acting via G protein-coupled receptors. Be ... Full text Open Access Link to item Cite

Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion.

Journal article J Biol Chem · June 15, 2001 Featured Publication Fractalkine (FKN/CX3CL1) is a unique member of the chemokine gene family and contains a chemokine domain (CD), a mucin-like stalk, a single transmembrane region, and a short intracellular C terminus. This structural distinction affords FKN the property of ... Full text Link to item Cite

Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency.

Journal article N Engl J Med · May 4, 2000 Featured Publication BACKGROUND: Immune function can be restored in infants with severe combined immunodeficiency by transplantation of unfractionated bone marrow from HLA-identical donors or T-cell-depleted marrow stem cells from haploidentical donors, with whom there is a si ... Full text Link to item Cite

Ultrastructure and function of the fractalkine mucin domain in CX(3)C chemokine domain presentation.

Journal article J Biol Chem · February 11, 2000 Featured Publication Fractalkine (FKN), a CX(3)C chemokine/mucin hybrid molecule on endothelium, functions as an adhesion molecule to capture and induce firm adhesion of a subset of leukocytes in a selectin- and integrin-independent manner. We hypothesized that the FKN mucin d ... Full text Link to item Cite

Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow.

Journal article J Exp Med · October 19, 1998 Featured Publication Leukocyte migration into sites of inflammation involves multiple molecular interactions between leukocytes and vascular endothelial cells, mediating sequential leukocyte capture, rolling, and firm adhesion. In this study, we tested the role of molecular in ... Full text Link to item Cite

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

Journal article Nat Genet · March 1997 Featured Publication Type 1, or insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease associated with loss of tolerance to several pancreatic islet cell molecules, including insulin, glutamic acid decarboxylase (GAD), ICA69 and the tyrosine phosphatase IA-2 (refs ... Full text Link to item Cite

Identification and characterization of a 100-kD ligand for CD6 on human thymic epithelial cells.

Journal article J Exp Med · April 1, 1995 Featured Publication CD6 is a 130-kD glycoprotein expressed on the surface of thymocytes and peripheral blood T cells that is involved in TCR-mediated T cell activation. In thymus, CD6 mediates interactions between thymocytes and thymic epithelial (TE) cells. In indirect immun ... Full text Link to item Cite

A poxvirus-derived vector that directs high levels of expression of cloned genes in mammalian cells.

Journal article Proc Natl Acad Sci U S A · December 1988 Featured Publication High levels of expression of cloned genes have been obtained in mammalian cells by using poxvirus-derived insertion/expression vectors. These vectors employ the cis-acting element (CAE I) that directs the transcription of one of the most strongly expressed ... Full text Link to item Cite

Messenger RNAs of a strongly-expressed late gene of cowpox virus contain 5'-terminal poly(A) sequences.

Journal article EMBO J · December 1, 1987 Featured Publication We have identified and characterized one of the most strongly-expressed genes of cowpox virus (CPV). This is the gene encoding the major protein component of the A-type inclusion bodies produced by this virus. This gene (designated the 160K gene) is transc ... Full text Link to item Cite