Skip to main content

Patricia Lynne Lugar

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
1821 Hillandale Rd, Suite 25A, Durham, NC 27705

Overview


I have a strong interest and research background in the study of dysregulated B lymphocytes, B cells, that characterize clinical disease such as autoimmune disease and humoral immune deficiency. My current research projects are aimed at the study of humoral immune deficiency, specifically common variable immune deficiency or CVID and the dysregulation of B cells in the generation of lymphoma and autoimmune disease.
Other ongoing research projects include characterizing the molecular and cellular events that cause a common disease, chronic idiopathic urticaria or CIU and rare disorders idiopathic anaphylaxis and idiopathic angioedema.

Current Appointments & Affiliations


Associate Professor of Medicine · 2021 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine
Associate Professor in Pediatrics · 2019 - Present Pediatrics, Allergy and Immunology, Pediatrics

In the News


Published April 10, 2024
Don’t Fear Pollen Season. There Are Tips for Relief
Published August 20, 2013
Duke Receives $1.3 Million for Immune Deficiency Research

View All News

Recent Publications


Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial.

Journal Article JAMA Intern Med · September 1, 2023 IMPORTANCE: Fewer than 5% of patients labeled with a penicillin allergy are truly allergic. The standard of care to remove the penicillin allergy label in adults is specialized testing involving prick and intradermal skin testing followed by an oral challe ... Full text Open Access Link to item Cite

Immunoglobulin Deficiency and the Unified Airway.

Journal Article Otolaryngol Clin North Am · February 2023 Primary Ig deficiencies are a heterogeneous group of disorders with widespread implications for the unified airway. Manifestations can vary greatly, with some patients being asymptomatic, whereas others suffering from acute and chronic life-threatening pat ... Full text Link to item Cite

Systemic IgG exposure and safety in patients with primary immunodeficiency: a randomized crossover study comparing a novel investigational wearable infusor versus the Crono pump.

Journal Article Immunotherapy · November 2022 Aim: A novel, Investigational Wearable Infusor (IWI) was evaluated in a randomized, controlled, crossover, open-label study to determine if its delivery of subcutaneous immunoglobulin (IgPro20) achieved a comparable area under the concentration-time curve ... Full text Link to item Cite
View All Publications

Recent Grants


R01: Genetic Origins of Adverse Outcomes in African Americans with Lymphoma

ResearchInvestigator · Awarded by National Institutes of Health · 2023 - 2028

Abatacept for the treatment of Common Variable Immunodeficiency with Interstitial Lung Disease (ABCVILD) - Cost Reimbursable

Clinical TrialPrincipal Investigator · Awarded by Cincinnati Children's Hospital Medical Center · 2021 - 2024

View All Grants

Education, Training & Certifications


State University of New York, Buffalo · 1999 M.D.