Scholars@Duke
Patricia Peterson

Scholarly Works - Journal articles

Distinct STRIPAK subunits drive conserved and subunit-specific signaling programs in Cryptococcus neoformans.

Journal article mBio · August 13, 2026 The striatin-interacting phosphatase and kinase (STRIPAK) complex is a conserved protein phosphatase 2A (PP2A)-associated signaling hub that integrates kinase-phosphatase networks, yet its roles in human fungal pathogens remain poorly defined. Here, we dis ... Full text Link to item Cite

Homeodomain protein Sxi1α independently controls cell-cell fusion and gene expression during sexual reproduction in Cryptococcus deneoformans.

Journal article PLoS Genet · March 2026 Sex-specific homeodomain (HD) proteins are key regulators of cell identity and sexual development in fungi, typically functioning as heterodimers to govern transcription. In the human fungal pathogens Cryptococcus neoformans and Cryptococcus deneoformans, ... Full text Link to item Cite

STRIPAK complex defects result in pseudosexual reproduction in Cryptococcus neoformans.

Journal article PLoS Genet · June 2025 STRIPAK is an evolutionarily conserved signaling complex that coordinates diverse cellular processes across fungi and animals. In the human fungal pathogen Cryptococcus neoformans, STRIPAK was recently shown to play critical roles in maintaining genome sta ... Full text Open Access Link to item Cite

The Cryptococcus neoformans STRIPAK complex controls genome stability, sexual development, and virulence.

Journal article PLoS Pathog · November 2024 The eukaryotic serine/threonine protein phosphatase PP2A is a heterotrimeric enzyme composed of a scaffold A subunit, a regulatory B subunit, and a catalytic C subunit. Of the four known B subunits, the B"' subunit (known as striatin) interacts with the mu ... Full text Open Access Link to item Cite

α-synuclein inhibits Snx3-retromer retrograde trafficking of the conserved membrane-bound proprotein convertase Kex2 in the secretory pathway of Saccharomyces cerevisiae.

Journal article Human molecular genetics · March 2022 We tested the ability of alpha-synuclein (α-syn) to inhibit Snx3-retromer-mediated retrograde trafficking of Kex2 and Ste13 between late endosomes and the trans-Golgi network (TGN) using a Saccharomyces cerevisiae model of Parkinson's disease. Kex2 and Ste ... Full text Open Access Cite

Identification and characterization of rapidly accumulating sch9Δ suppressor mutations in Saccharomyces cerevisiae.

Journal article G3 (Bethesda, Md.) · July 2021 Nutrient sensing is important for cell growth, aging, and longevity. In Saccharomyces cerevisiae, Sch9, an AGC-family protein kinase, is a major nutrient sensing kinase homologous to mammalian Akt and S6 kinase. Sch9 integrates environmental cues with cell ... Full text Open Access Cite