Patrick Georgoff

Conference Critical Care Medicine · March 1, 2026 Introduction: Rib fractures are a common injury in older trauma patients and are associated with high morbidity and mortality. In March 2022, our institution implemented a standardized rib fracture protocol emphasizing early ICU triage, multimodal analgesi ... Full text Cite

971: ASSOCIATION OF A RIB FRACTURE PROTOCOL WITH DECREASED NEED FOR MECHANICAL VENTILATION

Conference Critical Care Medicine · March 1, 2026 Introduction: Rib fractures are the most common traumatic thoracic injury and are a major contributor to overall morbidity and mortality, particularly among geriatric patients. Triage pathways have been proposed to standardize patient care and guide clinic ... Full text Cite

Transcriptomic changes following valproic acid treatment promote neurogenesis and minimize secondary brain injury.

Conference J Trauma Acute Care Surg · March 2018 BACKGROUND: Early treatment with valproic acid (VPA) has demonstrated benefit in preclinical models of traumatic brain injury, including smaller brain lesion size, decreased edema, reduced neurologic disability, and faster recovery. Mechanisms underlying t ... Full text Link to item Cite

Valproic acid decreases brain lesion size and improves neurologic recovery in swine subjected to traumatic brain injury, hemorrhagic shock, and polytrauma.

Conference J Trauma Acute Care Surg · December 2017 BACKGROUND: We have previously shown that treatment with valproic acid (VPA) decreases brain lesion size in swine models of traumatic brain injury (TBI) and controlled hemorrhage. To translate this treatment into clinical practice, validation of drug effic ... Full text Link to item Cite

Inhibition of histone deacetylase 6 restores innate immune cells in the bone marrow in a lethal septic model.

Conference J Trauma Acute Care Surg · January 2016 BACKGROUND: We have previously demonstrated that Tubastatin A, a selective inhibitor of histone deacetylase 6 (HDAC6), improves survival and increases circulating monocyte count and bacterial clearance in a lethal model of cecal ligation and puncture (CLP) ... Full text Link to item Cite