Skip to main content

Edward F. Patz Jr.

James and Alice Chen Distinguished Professor of Radiology
Radiology, Cardiothoracic Imaging
Box 3808 Med Ctr, Durham, NC 27710
1515B Hosp North, Durham, NC 27710

Selected Publications


Promotion of an Antitumor Immune Program by a Tumor-specific, Complement-activating Antibody.

Journal Article J Immunol · May 15, 2024 Tumor-targeting Abs can be used to initiate an antitumor immune program, which appears essential to achieve a long-term durable clinical response to cancer. We previously identified an anti-complement factor H (CFH) autoantibody associated with patients wi ... Full text Link to item Cite

Complement factor H: a novel innate immune checkpoint in cancer immunotherapy.

Journal Article Front Cell Dev Biol · 2024 The elimination of cancer cells critically depends on the immune system. However, cancers have evolved a variety of defense mechanisms to evade immune monitoring, leading to tumor progression. Complement factor H (CFH), predominately known for its function ... Full text Link to item Cite

Characterizing Lung-RADS category 4 lesions in a university lung cancer screening program.

Journal Article Lung Cancer · December 2023 OBJECTIVES: To assess the prevalence of lung cancer in Lung-RADS category 4 patients, and to elucidate if clinical or imaging features help differentiate benign lesions from lung cancer. MATERIALS/METHODS: A retrospective review of lung cancer screening (L ... Full text Link to item Cite

Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103.

Journal Article Mol Cancer Ther · June 1, 2023 Development of novel therapeutic antibodies that not only kill tumor cells but modulate the adaptive immune response has the potential to produce long term anticancer immunity and a durable clinical response. We previously reported the discovery of anti-co ... Full text Link to item Cite

Figure S4 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Gating strategy for detection of ADCP.</p> ... Full text Cite

Figure S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Deposition of intratumoral C3dg and C3d.</p> ... Full text Cite

Figure S3 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Flow cytometry histograms of C3b/iC3b or C1q binding to NSCLC cells incubated with normal human serum (NHS) or depleted (Dpl) NHS + antibodies.</p> ... Full text Cite

Table S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Genes regulated by GT103 in total intratumoral B cells</p> ... Full text Cite

Figure S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Immunofluorescence of 33 human lung tumor samples on a microarray probed with GT103.</p> ... Full text Cite

Figure S3 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Flow cytometry histograms of C3b/iC3b or C1q binding to NSCLC cells incubated with normal human serum (NHS) or depleted (Dpl) NHS + antibodies.</p> ... Full text Cite

Table S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Genes regulated by GT103 in CR2+ intratumoral B cells</p> ... Full text Cite

Table S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Genes regulated by GT103 in CR2+ intratumoral B cells</p> ... Full text Cite

Figure S5 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Gating strategy for detection of phosphorylated Syk kinase in B cells.</p> ... Full text Cite

Figure S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Immunofluorescence of 33 human lung tumor samples on a microarray probed with GT103.</p> ... Full text Cite

Figure S5 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Gating strategy for detection of phosphorylated Syk kinase in B cells.</p> ... Full text Cite

Data from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <div>Abstract<p>Development of novel therapeutic antibodies that not only kill tumor cells but modulate the adaptive immune response has the potential to produce long term anticancer immunity and a durable clinical response. We previous ... Full text Cite

Data from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <div>Abstract<p>Development of novel therapeutic antibodies that not only kill tumor cells but modulate the adaptive immune response has the potential to produce long term anticancer immunity and a durable clinical response. We previous ... Full text Cite

Figure S4 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Gating strategy for detection of ADCP.</p> ... Full text Cite

Figure S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Deposition of intratumoral C3dg and C3d.</p> ... Full text Cite

Table S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Genes regulated by GT103 in total intratumoral B cells</p> ... Full text Cite

Promotion of an Antitumor Immune Program by a Tumor-specific, Complement-activating Antibody.

Journal Article J Immunol · May 15, 2024 Tumor-targeting Abs can be used to initiate an antitumor immune program, which appears essential to achieve a long-term durable clinical response to cancer. We previously identified an anti-complement factor H (CFH) autoantibody associated with patients wi ... Full text Link to item Cite

Complement factor H: a novel innate immune checkpoint in cancer immunotherapy.

Journal Article Front Cell Dev Biol · 2024 The elimination of cancer cells critically depends on the immune system. However, cancers have evolved a variety of defense mechanisms to evade immune monitoring, leading to tumor progression. Complement factor H (CFH), predominately known for its function ... Full text Link to item Cite

Characterizing Lung-RADS category 4 lesions in a university lung cancer screening program.

Journal Article Lung Cancer · December 2023 OBJECTIVES: To assess the prevalence of lung cancer in Lung-RADS category 4 patients, and to elucidate if clinical or imaging features help differentiate benign lesions from lung cancer. MATERIALS/METHODS: A retrospective review of lung cancer screening (L ... Full text Link to item Cite

Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103.

Journal Article Mol Cancer Ther · June 1, 2023 Development of novel therapeutic antibodies that not only kill tumor cells but modulate the adaptive immune response has the potential to produce long term anticancer immunity and a durable clinical response. We previously reported the discovery of anti-co ... Full text Link to item Cite

Figure S4 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Gating strategy for detection of ADCP.</p> ... Full text Cite

Figure S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Deposition of intratumoral C3dg and C3d.</p> ... Full text Cite

Figure S3 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Flow cytometry histograms of C3b/iC3b or C1q binding to NSCLC cells incubated with normal human serum (NHS) or depleted (Dpl) NHS + antibodies.</p> ... Full text Cite

Table S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Genes regulated by GT103 in total intratumoral B cells</p> ... Full text Cite

Figure S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Immunofluorescence of 33 human lung tumor samples on a microarray probed with GT103.</p> ... Full text Cite

Figure S3 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Flow cytometry histograms of C3b/iC3b or C1q binding to NSCLC cells incubated with normal human serum (NHS) or depleted (Dpl) NHS + antibodies.</p> ... Full text Cite

Table S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Genes regulated by GT103 in CR2+ intratumoral B cells</p> ... Full text Cite

Table S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Genes regulated by GT103 in CR2+ intratumoral B cells</p> ... Full text Cite

Figure S5 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Gating strategy for detection of phosphorylated Syk kinase in B cells.</p> ... Full text Cite

Figure S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Immunofluorescence of 33 human lung tumor samples on a microarray probed with GT103.</p> ... Full text Cite

Figure S5 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Gating strategy for detection of phosphorylated Syk kinase in B cells.</p> ... Full text Cite

Data from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <div>Abstract<p>Development of novel therapeutic antibodies that not only kill tumor cells but modulate the adaptive immune response has the potential to produce long term anticancer immunity and a durable clinical response. We previous ... Full text Cite

Data from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <div>Abstract<p>Development of novel therapeutic antibodies that not only kill tumor cells but modulate the adaptive immune response has the potential to produce long term anticancer immunity and a durable clinical response. We previous ... Full text Cite

Figure S4 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Gating strategy for detection of ADCP.</p> ... Full text Cite

Figure S2 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Deposition of intratumoral C3dg and C3d.</p> ... Full text Cite

Table S1 from Antitumor Immune Mechanisms of the Anti-Complement Factor H Antibody GT103

Other · June 1, 2023 <p>Genes regulated by GT103 in total intratumoral B cells</p> ... Full text Cite

Perspective: rethinking therapeutic strategies in oncology.

Journal Article Front Oncol · 2023 Immuno-oncology has revolutionized cancer care, drug development, the design of clinical trials, standard treatment paradigms, and the evaluation of response to therapy. These are all areas, however, that have not fully incorporated principles of tumor imm ... Full text Link to item Cite

Genetic variants in DDO and PEX5L in peroxisome-related pathways predict non-small cell lung cancer survival.

Journal Article Mol Carcinog · July 2022 Peroxisomes play a role in lipid metabolism and regulation of reactive oxygen species, but its role in development and progression of non-small cell lung cancer (NSCLC) is not well understood. Here, we investigated the associations between 9708 single-nucl ... Full text Open Access Link to item Cite

Single nucleotide polymorphisms in FOXP1 and RORA of the lymphocyte activation-related pathway affect survival of lung cancer patients.

Journal Article Transl Lung Cancer Res · May 2022 BACKGROUND: Lymphocyte activation is part of a complex microenvironment that affects the development and progression of solid tumors. The present study analyzed the associations between genetic variants in lymphocyte activation-related genes and survival o ... Full text Open Access Link to item Cite

Mediastinal Lymphadenopathy in the National Lung Screening Trial (NLST) Is Associated with Interval Lung Cancer.

Journal Article Radiology · March 2022 Background There are currently no evidence-based guidelines for the management of enlarged mediastinal lymph nodes found on lung cancer screening (LCS) CT scans. Purpose To assess the frequency and clinical significance of enlarged mediastinal lymph nodes ... Full text Link to item Cite

Prognostic significance of a complement factor H autoantibody in early stage NSCLC.

Journal Article Cancer Biomark · 2022 BACKGROUND: Biomarkers that predict which patients with early stage NSCLC will develop recurrent disease would be of clinical value. We previously discovered that an autoantibody to a complement regulatory protein, complement factor H (CFH), is associated ... Full text Open Access Link to item Cite

Upregulation of complement proteins in lung cancer cells mediates tumor progression.

Journal Article Front Oncol · 2022 INTRODUCTION: In vivo, cancer cells respond to signals from the tumor microenvironment resulting in changes in expression of proteins that promote tumor progression and suppress anti-tumor immunity. This study employed an orthotopic immunocompetent model o ... Full text Link to item Cite

Genetic variants of CHEK1, PRIM2 and CDK6 in the mitotic phase-related pathway are associated with nonsmall cell lung cancer survival.

Journal Article Int J Cancer · September 15, 2021 The mitotic phase is a vital step in cell division and may be involved in cancer progression, but it remains unclear whether genetic variants in mitotic phase-related pathways genes impact the survival of these patients. Here, we investigated associations ... Full text Open Access Link to item Cite

Clinical Significance of Lung-RADS Category 3 Lesions in the National Lung Screening Trial.

Journal Article J Thorac Oncol · July 2021 INTRODUCTION: To determine the clinical significance of category 3 (CAT3) abnormalities and the necessity of a 6-month follow-up computed tomography (CT). We also explored features associated with increased lung cancer risk. METHODS: From the National Lung ... Full text Link to item Cite

Coming together at the hinges: Therapeutic prospects of IgG3.

Journal Article MAbs · 2021 The human IgG3 subclass is conspicuously absent among the formats for approved monoclonal antibody therapies and Fc fusion protein biologics. Concern about the potential for rapid degradation, reduced plasma half-life, and increased immunogenicity due to m ... Full text Link to item Cite

Genetic variants of DOCK2, EPHB1 and VAV2 in the natural killer cell-related pathway are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2021 Although natural killer (NK) cells are a known major player in anti-tumor immunity, the effect of genetic variation in NK-associated genes on survival in patients with non-small cell lung cancer (NSCLC) remains unknown. Here, in 1,185 with NSCLC cases of a ... Open Access Link to item Cite

Complement factor H protects tumor cell-derived exosomes from complement-dependent lysis and phagocytosis.

Journal Article PLoS One · 2021 Exosomes are a class of extracellular vesicles (EVs) that are mediators of normal intercellular communication, but exosomes are also used by tumor cells to promote oncogenesis and metastasis. Complement factor H (CFH) protects host cells from attack and de ... Full text Link to item Cite

Electrochemical micro-aptasensors for exosome detection based on hybridization chain reaction amplification.

Journal Article Microsyst Nanoeng · 2021 Exosomes are cell-derived nanovesicles that have recently gained popularity as potential biomarkers in liquid biopsies due to the large amounts of molecular cargo they carry, such as nucleic acids and proteins. However, most existing exosome-based analytic ... Full text Link to item Cite

Genetic Variants of CLPP and M1AP Are Associated With Risk of Non-Small Cell Lung Cancer.

Journal Article Front Oncol · 2021 BACKGROUND: Single nucleotide polymorphisms (SNPs) are often associated with distinct phenotypes in cancer. The present study investigated associations of cancer risk and outcomes with SNPs discovered by whole exome sequencing of normal lung tissue DNA of ... Full text Link to item Cite

Genetic Variants of CLEC4E and BIRC3 in Damage-Associated Molecular Patterns-Related Pathway Genes Predict Non-Small Cell Lung Cancer Survival.

Journal Article Front Oncol · 2021 Accumulating evidence supports a role of various damage-associated molecular patterns (DAMPs) in progression of lung cancer, but roles of genetic variants of the DAMPs-related pathway genes in lung cancer survival remain unknown. We investigated associatio ... Full text Open Access Link to item Cite

Tumour extracellular vesicle-derived Complement Factor H promotes tumorigenesis and metastasis by inhibiting complement-dependent cytotoxicity of tumour cells.

Journal Article J Extracell Vesicles · November 2020 The complement system is involved in the immunosurveillance of pathogens and tumour cells. Proteomic profiling revealed that extracellular vesicles (EVs) released by metastatic hepatocellular carcinoma (HCC) cells contained a significant number of compleme ... Full text Link to item Cite

Novel genetic variants in genes of the Fc gamma receptor-mediated phagocytosis pathway predict non-small cell lung cancer survival.

Journal Article Transl Lung Cancer Res · June 2020 BACKGROUND: Both antibody-dependent cellular cytotoxicity and phagocytosis activate innate immunity, and the Fc gamma receptor (FCGR)-mediated phagocytosis is an integral part of the process. We assessed associations between single-nucleotide polymorphisms ... Full text Open Access Link to item Cite

Novel genetic variants in HDAC2 and PPARGC1A of the CREB-binding protein pathway predict survival of non-small-cell lung cancer.

Journal Article Mol Carcinog · January 2020 The CREB-binding protein (CBP) pathway plays an important role in transcription and activity of acetyltransferase that acetylates lysine residues of histones and nonhistone proteins. In the present study, we hypothesized that genetic variants in the CBP pa ... Full text Open Access Link to item Cite

Novel genetic variants of SYK and ITGA1 related lymphangiogenesis signaling pathway predict non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 Although lymphangiogenesis is a vital step in lung cancer metastasis, the association between lymphangiogenesis and non-small cell lung cancer (NSCLC) survival remains unclear. Since single-nucleotide polymorphisms (SNPs) have been reported to predict NSCL ... Open Access Link to item Cite

Genetic variants of BIRC3 and NRG1 in the NLRP3 inflammasome pathway are associated with non-small cell lung cancer survival.

Journal Article Am J Cancer Res · 2020 The nod-like receptor protein 3 (NLRP3) is one of the most characterized inflammasomes, and its genetic variation and functional dysregulation are involved in pathogenesis of several cancers. To systematically evaluate the role of NLRP3 in predicting outco ... Open Access Link to item Cite

Genetic variants in RUNX3, AMD1 and MSRA in the methionine metabolic pathway and survival in nonsmall cell lung cancer patients.

Journal Article Int J Cancer · August 1, 2019 Abnormal methionine dependence in cancer cells has led to methionine restriction as a potential therapeutic strategy. We hypothesized that genetic variants involved in methionine-metabolic genes are associated with survival in nonsmall cell lung cancer (NS ... Full text Open Access Link to item Cite

Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival.

Journal Article Int J Cancer · April 15, 2019 The complement system plays an important role in the innate and adaptive immunity, complement components mediate tumor cytolysis of antibody-based immunotherapy, and complement activation in the tumor microenvironment may promote tumor progression or inhib ... Full text Open Access Link to item Cite

Whole Exome Sequencing of Cell-Free DNA for Early Lung Cancer: A Pilot Study to Differentiate Benign From Malignant CT-Detected Pulmonary Lesions.

Journal Article Front Oncol · 2019 Introduction: Indeterminate pulmonary lesions (IPL) detected by CT pose a significant clinical challenge, frequently necessitating long-term surveillance or biopsy for diagnosis. In this pilot investigation, we performed whole exome sequencing (WES) of pla ... Full text Link to item Cite

Sequential CT Findings in Patients With Non-small-cell Lung Cancer Receiving Nivolumab.

Journal Article Clin Lung Cancer · March 2018 BACKGROUND: Nivolumab is a novel immunotherapy that was recently approved for treatment of advanced non-small-cell lung cancer (NSCLC). Patients treated with checkpoint inhibitors may show variable computed tomography (CT) features on follow-up imaging, an ... Full text Link to item Cite

A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer.

Journal Article PLoS One · 2018 Computed tomography (CT) is the standard imaging test used for the screening and assessment of suspected lung cancer, but distinguishing malignant from benign nodules by CT is an ongoing challenge. Consequently, a large number of avoidable invasive procedu ... Full text Open Access Link to item Cite

Rethinking Autoantibody Signature Panels for Cancer Diagnosis.

Journal Article J Thorac Oncol · June 2017 INTRODUCTION: Most pulmonary nodules found on imaging studies are indeterminate, but because of the concern for lung cancer, all patients require further evaluation with resultant radiation risk, significant cost, and delays in diagnosis. We hypothesized t ... Full text Link to item Cite

Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody.

Journal Article PLoS One · 2017 Rituximab therapy for B cell chronic lymphocytic leukemia (B-CLL) has met with mixed success. Among several factors to which resistance can be attributed is failure to activate complement dependent cytotoxicity (CDC) due to protective complement regulatory ... Full text Link to item Cite

Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression.

Journal Article Cancer Discov · September 2016 UNLABELLED: In contrast to its inhibitory effects on many cells, IL10 activates CD8(+) tumor-infiltrating lymphocytes (TIL) and enhances their antitumor activity. However, CD8(+) TILs do not routinely express IL10, as autocrine complement C3 inhibits IL10 ... Full text Link to item Cite

A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.

Journal Article Cell Rep · May 17, 2016 Some patients with cancer never develop metastasis, and their host response might provide cues for innovative treatment strategies. We previously reported an association between autoantibodies against complement factor H (CFH) and early-stage lung cancer. ... Full text Open Access Link to item Cite

Lung cancer incidence and mortality in National Lung Screening Trial participants who underwent low-dose CT prevalence screening: a retrospective cohort analysis of a randomised, multicentre, diagnostic screening trial.

Journal Article Lancet Oncol · May 2016 BACKGROUND: Annual low-dose CT screening for lung cancer has been recommended for high-risk individuals, but the necessity of yearly low-dose CT in all eligible individuals is uncertain. This study examined rates of lung cancer in National Lung Screening T ... Full text Link to item Cite

Catheter Drainage of Intrathoracic Collections

Chapter · April 22, 2016 Packed with useful information on common procedures in interventional radiology, this popular handbook has been thoroughly updated to keep you up to speed with rapid changes in the field. ... Cite

Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery.

Journal Article Cancer Immunol Immunother · February 2016 Intratumoral B lymphocytes are an integral part of the lung tumor microenvironment. Interrogation of the antibodies they express may improve our understanding of the host response to cancer and could be useful in elucidating novel molecular targets. We use ... Full text Open Access Link to item Cite

Complement Factor H Antibodies from Lung Cancer Patients Induce Complement-Dependent Lysis of Tumor Cells, Suggesting a Novel Immunotherapeutic Strategy.

Journal Article Cancer Immunol Res · December 2015 Characterization of the humoral immune response in selected patients with cancer who uniformly do well may lead to the development of novel therapeutic strategies. We have previously shown an association between patients with early-stage nonmetastatic lung ... Full text Link to item Cite

Primary tumour standardised uptake value is prognostic in nonsmall cell lung cancer: a multivariate pooled analysis of individual data.

Journal Article Eur Respir J · December 2015 (18)F-fluoro-2-deoxy-d-glucose positron emission tomography (PET) complements conventional imaging for diagnosing and staging lung cancer. Two literature-based meta-analyses suggest that maximum standardised uptake value (SUVmax) on PET has univariate prog ... Full text Link to item Cite

FDG Uptake on Positron Emission Tomography Correlates with Survival and Time to Recurrence in Patients with Stage I Non-Small-Cell Lung Cancer.

Journal Article J Thorac Oncol · June 2015 INTRODUCTION: Patients with stage I non-small-cell lung cancer (NSCLC) have a wide variation in outcomes, most likely because there are undetected metastases at presentation. We retrospectively reviewed patients with early stage lung cancer to determine if ... Full text Link to item Cite

National Lung Screening Trial findings by age: Medicare-eligible versus under-65 population.

Journal Article Ann Intern Med · November 4, 2014 BACKGROUND: The NLST (National Lung Screening Trial) showed reduced lung cancer mortality in high-risk participants (smoking history of ≥30 pack-years) aged 55 to 74 years who were randomly assigned to screening with low-dose computed tomography (LDCT) ver ... Full text Link to item Cite

Conflict of interest disclosures.

Journal Article JAMA Intern Med · May 2014 Full text Link to item Cite

Missing Conflict of Interest Disclosures

Journal Article JAMA Internal Medicine · May 1, 2014 Full text Cite

Redistribution of health care costs after the adoption of positron emission tomography among medicare beneficiaries with non-small-cell lung cancer, 1998-2005.

Journal Article J Thorac Oncol · April 2014 INTRODUCTION: Treatment patterns and cost implications of increased positron emission tomography imaging use since Medicare approval in 1998 are not well understood. We examined rates of surgery, radiotherapy, and chemotherapy and inpatient and total healt ... Full text Link to item Cite

Overdiagnosis in low-dose computed tomography screening for lung cancer.

Journal Article JAMA Intern Med · February 1, 2014 IMPORTANCE: Screening for lung cancer has the potential to reduce mortality, but in addition to detecting aggressive tumors, screening will also detect indolent tumors that otherwise may not cause clinical symptoms. These overdiagnosis cases represent an i ... Full text Link to item Cite

PET-CT: current applications and new developments in the thorax.

Journal Article Semin Respir Crit Care Med · February 2014 Positron emission tomography computed tomography(PET-CT) imaging has emerged as an essential clinical diagnostic tool in the evaluation of thoracic abnormalities. Currently, its primary role is for tumor imaging; it helps to differentiate benign from malig ... Full text Link to item Cite

Biomarkers to help guide management of patients with pulmonary nodules.

Journal Article Am J Respir Crit Care Med · August 15, 2013 RATIONALE: Indeterminate pulmonary nodules are a common radiographic finding and require further evaluation because of the concern for lung cancer. OBJECTIVES: We developed an algorithm to assign patients to a low- or high-risk category for lung cancer, ba ... Full text Open Access Link to item Cite

Variations in use of PET among Medicare beneficiaries with non-small cell lung cancer, 1998-2007.

Journal Article Radiology · June 2013 PURPOSE: To explore demographic and regional factors associated with the use of positron emission tomography (PET) in patients with non-small cell lung cancer (NSCLC) and to determine whether their associations with PET use has changed over time. MATERIALS ... Full text Link to item Cite

Reply to M.S. Hofman et al.

Journal Article J Clin Oncol · February 20, 2013 Full text Link to item Cite

Preliminary evaluation of biplane correlation (BCI) stereographic imaging for lung nodule detection.

Journal Article J Digit Imaging · February 2013 A biplane correlation (BCI) imaging system obtains images that can be viewed in stereo, thereby minimizing overlapping structures. This study investigated whether using stereoscopic visualization provides superior lung nodule detection compared to standard ... Full text Link to item Cite

Future trends in lung cancer diagnosis.

Journal Article Radiol Clin North Am · September 2012 Imaging continues to play an essential role in evaluating patients with lung cancer. Improvement in radiologic techniques will produce more accurate diagnostic information, but complementing conventional studies with molecular diagnostics will likely have ... Full text Link to item Cite

Stage migration, selection bias, and survival associated with the adoption of positron emission tomography among medicare beneficiaries with non-small-cell lung cancer, 1998-2003.

Journal Article J Clin Oncol · August 1, 2012 PURPOSE: Previous studies have linked the use of positron emission tomography (PET) with improved outcomes among patients with non-small-cell lung cancer (NSCLC). However, this association may be confounded by PET-induced stage migration and selection bias ... Full text Link to item Cite

Identification of potential prognostic biomarkers in patients with untreated, advanced pancreatic cancer from a phase 3 trial (Cancer and Leukemia Group B 80303).

Journal Article Cancer · January 15, 2012 BACKGROUND: Patients with advanced stage adenocarcinoma of the pancreas have a poor prognosis. The identification of prognostic and/or predictive biomarkers may help stratify patients so that therapy can be individualized. METHODS: Serum samples from patie ... Full text Link to item Cite

The Association of Intratumoral Germinal Centers with early-stage non-small cell lung cancer.

Journal Article J Thorac Oncol · October 2011 INTRODUCTION: Lung cancers can display immune cell infiltration although the role of an adaptive immune response in disease pathogenesis is unknown. To investigate the possibility of a functional humoral response to the tumor, we surveyed histologic sectio ... Full text Link to item Cite

The National Lung Screening Trial: overview and study design.

Journal Article Radiology · January 2011 The National Lung Screening Trial (NLST) is a randomized multicenter study comparing low-dose helical computed tomography (CT) with chest radiography in the screening of older current and former heavy smokers for early detection of lung cancer, which is th ... Full text Link to item Cite

Discovery of novel cyclophilin A ligands using an H/D exchange- and mass spectrometry-based strategy.

Journal Article J Biomol Screen · October 2010 Cyclophilin A (CypA) is an overexpressed protein in lung cancer tumors and as a result is a potential therapeutic and diagnostic target. Described here is use of an H/D exchange- and a matrix assisted laser desorption/ionization (MALDI) mass spectrometry-b ... Full text Link to item Cite

The role of biomarkers in thoracic imaging

Journal Article Imaging in Medicine · October 1, 2010 Thoracic imaging plays an essential role in understanding and diagnosing chest disease. It has traditionally relied on conventional anatomic and morphologic imaging, but as technology evolves, novel diagnostic strategies have the potential to improve accur ... Full text Cite

National Lung Cancer Screening Trial American College of Radiology Imaging Network Specimen Biorepository originating from the Contemporary Screening for the Detection of Lung Cancer Trial (NLST, ACRIN 6654): design, intent, and availability of specimens for validation of lung cancer biomarkers.

Journal Article J Thorac Oncol · October 2010 Lung cancer continues to be a major public health problem, and more patients die from this disease than any other cancer. The vast majority of patients present with advanced stage disease when therapeutic options are limited and the overall 5 year survival ... Full text Link to item Cite

Correlation of [18F]-2-fluoro-deoxy-D-glucose positron emission tomography standard uptake values with the cellular composition of stage I nonsmall cell lung cancer.

Journal Article Cancer · September 1, 2010 BACKGROUND: The aim of the current study was to determine whether the [18F]-2-fluoro-deoxy-D-glucose (FDG) positron emission tomography (PET) standardized uptake value (SUV) in patients with a new diagnosis of stage I lung cancer correlates with a specific ... Full text Link to item Cite

Complement factor H autoantibodies are associated with early stage NSCLC.

Journal Article Clin Cancer Res · June 15, 2010 PURPOSE: To discover diagnostic biomarkers associated with early-stage non-small cell lung cancer (NSCLC), we searched for autoantibodies preferentially present in stage I patients compared with patients with advanced-stage disease. Here we describe an aut ... Full text Link to item Cite

Changes in the use and costs of diagnostic imaging among Medicare beneficiaries with cancer, 1999-2006.

Journal Article JAMA · April 28, 2010 CONTEXT: Emerging technologies, changing diagnostic and treatment patterns, and changes in Medicare reimbursement are contributing to increasing use of imaging in cancer. Imaging is the fastest growing expense for Medicare but has not been examined among b ... Full text Link to item Cite

Thoracic imaging.

Journal Article Respirology · April 2010 The various techniques encompassed in the term 'Thoracic Imaging' have had a dramatic effect on the practice of respiratory medicine over the last 25 years. One of many examples is the increased precision with which lung cancer can be preoperatively staged ... Full text Link to item Cite

Implementation of IASLC revised staging system: imaging implications

Journal Article JOURNAL OF THORACIC ONCOLOGY · September 1, 2009 Link to item Cite

Hydrogen/deuterium exchange- and protease digestion-based screening assay for protein-ligand binding detection.

Journal Article Anal Chem · August 15, 2009 A protease digestion strategy was incorporated into single-point stability of unpurified proteins from rates of H/D exchange (SUPREX), which is a hydrogen/deuterium (H/D) exchange- and mass spectrometry-based assay for the detection of protein-ligand bindi ... Full text Link to item Cite

Early changes in tumor size in patients treated for advanced stage nonsmall cell lung cancer do not correlate with survival.

Journal Article Cancer · February 1, 2009 Featured Publication BACKGROUND: In clinical trials, change in tumor size is used to stratify patients into response categories. The objective of the current study was to: 1) determine whether early change in the tumor size were correlated with survival in patients with advanc ... Full text Link to item Cite

Isolation of novel EGFR-specific VHH domains.

Journal Article J Biomol Screen · January 2009 Featured Publication Epidermal growth factor receptor (EGFR) is overexpressed or mutated in a high percentage of tumors. EGFR has long been considered a promising target for cancer diagnostic and therapeutic applications. However, monoclonal antibodies and other large antibody ... Full text Link to item Cite

Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection.

Journal Article J Am Soc Mass Spectrom · September 2008 Featured Publication An H/D exchange- and MALDI mass spectrometry-based screening assay was applied to search for novel ligands that bind to cyclophilin A, a potential therapeutic and diagnostic target in lung cancer. The assay is based on stability of unpurified proteins from ... Full text Link to item Cite

Validation of two models to estimate the probability of malignancy in patients with solitary pulmonary nodules.

Journal Article Thorax · April 2008 Featured Publication BACKGROUND: Effective strategies for managing patients with solitary pulmonary nodules (SPN) depend critically on the pre-test probability of malignancy. OBJECTIVE: To validate two previously developed models that estimate the probability that an indetermi ... Full text Link to item Cite

Prognostic value of fluorine-18 fluorodeoxyglucose positron emission tomography imaging in patients with advanced-stage non-small-cell lung carcinoma.

Journal Article J Clin Oncol · March 20, 2008 Featured Publication PURPOSE: To determine whether the amount of fluorine-18 fluorodeoxyglucose (FDG) uptake in the primary lung cancer on positron emission tomography (PET) imaging at the time of presentation has prognostic significance in patients with advanced-stage non-sma ... Full text Link to item Cite

Primary tumor standardized uptake value (SUVmax) measured on fluorodeoxyglucose positron emission tomography (FDG-PET) is of prognostic value for survival in non-small cell lung cancer (NSCLC): a systematic review and meta-analysis (MA) by the European Lung Cancer Working Party for the IASLC Lung Cancer Staging Project.

Journal Article J Thorac Oncol · January 2008 Featured Publication HYPOTHESIS: The 2-[18F]-fluoro-2-deoxy-d-glucose positron emission tomography is an imaging tool for assessing clinical tumor, node, metastasis in non-small cell lung cancer (NSCLC). Primary tumor standardized uptake value (SUV) has been studied as a poten ... Full text Link to item Cite

Panel of serum biomarkers for the diagnosis of lung cancer.

Journal Article J Clin Oncol · December 10, 2007 Featured Publication PURPOSE: Currently, a blood test for lung cancer does not exist. Serum biomarkers that could aid clinicians in making case management decisions would be enormously valuable. We used two proteomic platforms and a literature search to select candidate serum ... Full text Link to item Cite

Frequency and prognostic significance of preoperatively detected enlarged regional lymph nodes in patients with pathological stage I non-small cell lung cancer following resection.

Journal Article J Thorac Oncol · December 2007 PURPOSE: To explore the clinical significance of enlarged regional lymph nodes in patients with pathological stage I non-small cell lung cancer (NSCLC). MATERIAL AND METHODS: We retrospectively reviewed the tumor registry of the International Association f ... Full text Link to item Cite

Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer.

Journal Article Cancer · November 15, 2007 Featured Publication BACKGROUND: The purpose was to evaluate the clinical utility of serum haptoglobin (Hp) and posttranslational glycan modifications of Hp for the diagnosis of nonsmall cell lung cancer (NSCLC). METHODS: Serum proteins from patients with a new diagnosis of NS ... Full text Link to item Cite

The IASLC Lung Cancer Staging Project: proposals for revision of the M descriptors in the forthcoming (seventh) edition of the TNM classification of lung cancer.

Journal Article J Thorac Oncol · August 2007 PURPOSE: To analyze all nonlymphatic metastatic components (T4 and M1) of the current TNM system of lung cancer, with the objective of providing suggestions for the next edition of the TNM classification for lung cancer. MATERIAL AND METHODS: Data on 100,8 ... Full text Link to item Cite

Clinical stage I non-small cell lung cancer including FDG-PET Imaging: sites and time to recurrence.

Journal Article J Thorac Oncol · June 2007 INTRODUCTION: Positron emission tomography (PET) has improved the accuracy of staging non-small cell lung cancer (NSCLC), although some early-stage patients will still relapse. The purpose of this study was to determine the sites and time to recurrence in ... Full text Link to item Cite

Practical approach to diagnostic CT combined with PET.

Journal Article AJR Am J Roentgenol · March 2007 OBJECTIVE: Protocols for PET/CT are not yet standardized. In particular, image quality, utilization, and reporting of the findings of the CT component of PET/CT can vary widely, making it complicated for physicians to request the appropriate information. I ... Full text Link to item Cite

Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients.

Journal Article Cancer · December 15, 2006 Featured Publication BACKGROUND: Early stage lung cancer has a variable prognosis, and there are currently no markers that predict which patients will recur. This study examined the relation between tumor-regulatory T (Treg) cells and total tumor-infiltrating T-cell lymphocyte ... Full text Link to item Cite

Proteomics with mass spectrometry

Journal Article · December 1, 2006 This chapter provides a rudimentary review of the field of proteomics as it applies to mass spectrometry, data handling, and analysis. It points out the potential significance of the field suggesting that the study of nuclei acids has its limitations and t ... Full text Cite

Radiographic imaging of bronchioloalveolar carcinoma: screening, patterns of presentation and response assessment.

Journal Article J Thorac Oncol · November 2006 Bronchioloalveolar carcinoma (BAC) is a previously uncommon subset of adenocarcinoma with unique epidemiology, pathology, radiographic presentation, clinical features, and natural history compared with other non-small cell lung cancer (NSCLC) subtypes. Cla ... Link to item Cite

Lung cancer screening, overdiagnosis bias, and reevaluation of the Mayo Lung Project.

Journal Article J Natl Cancer Inst · June 7, 2006 Featured Publication Full text Link to item Cite

Integration of biomarkers and imaging.

Journal Article J Thorac Oncol · January 2006 Featured Publication Imaging studies provide essential diagnostic information in the care of cancer patients. Unfortunately, radiographic findings are not always diagnostic and thus an alternative approach with biomarkers has been suggested as part of the diagnostic evaluation ... Link to item Cite

Finding diagnostic biomarkers in proteomic spectra.

Conference Pac Symp Biocomput · 2006 In seeking to find diagnostic biomarkers in proteomic spectra, two significant problems arise. First, not only is there noise in the measured intensity at each m/z value, but there is also noise in the measured m/z value itself. Second, the potential for o ... Link to item Cite

Radiographic imaging of bronchioloalveolar carcinoma: Screening, patterns of presentation and response assessment

Journal Article Journal of Thoracic Oncology · January 1, 2006 Bronchioloalveolar carcinoma (BAC) is a previously uncommon subset of adenocarcinoma with unique epidemiology, pathology, radiographic presentation, clinical features, and natural history compared with other non-small cell lung cancer (NSCLC) subtypes. Cla ... Full text Cite

In reply [4]

Journal Article Journal of Clinical Oncology · December 1, 2005 Full text Cite

In reply [12]

Journal Article Journal of Clinical Oncology · December 1, 2005 Full text Cite

Consensus statement: CT screening for lung cancer

Journal Article Journal of Thoracic Imaging · November 1, 2005 Full text Cite

Guidelines for management of small pulmonary nodules detected on CT scans: a statement from the Fleischner Society.

Journal Article Radiology · November 2005 Featured Publication Lung nodules are detected very commonly on computed tomographic (CT) scans of the chest, and the ability to detect very small nodules improves with each new generation of CT scanner. In reported studies, up to 51% of smokers aged 50 years or older have pul ... Full text Link to item Cite

Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth in vivo.

Journal Article Cancer Res · October 1, 2005 Featured Publication Cyclophilin A (CypA) was recently reported to be overexpressed in non-small-cell lung cancer, and represents a potentially novel therapeutic target. To determine the role of CypA in oncogenesis, stable RNA interference (RNAi)-mediated knockdown of CypA was ... Full text Link to item Cite

Characterising phase variations in MALDI-TOF data and correcting them by peak alignment.

Journal Article Cancer Inform · 2005 The use of MALDI-TOF mass spectrometry as a means of analyzing the proteome has been evaluated extensively in recent years. One of the limitations of this technique that has impeded the development of robust data analysis algorithms is the variability in t ... Open Access Link to item Cite

Translating biomarkers into clinical practice: prognostic implications of cyclophilin A and macrophage migratory inhibitory factor identified from protein expression profiles in non-small cell lung cancer.

Journal Article Lung Cancer · December 2004 Featured Publication Biomarkers have the potential to significantly change diagnostic strategies and influence therapeutic management. We developed a MALDI-TOF protein expression profiling platform for biomarker discovery and a proof-of-principle study identified two proteins, ... Full text Link to item Cite

Using phage peptides to detect protein differences between cancer and normal tissues

Journal Article Cancer Biology and Therapy · December 1, 2004 Cite

Accentuation of differentially expressed proteins using phage technology.

Journal Article Anal Biochem · October 15, 2004 Featured Publication Protein profiling is frequently used to elucidate disease-specific or differentially expressed proteins. While recent developments have resulted in improved differential profiling, alternative expression platforms that complement existing techniques are co ... Full text Link to item Cite

Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate.

Journal Article Anal Chem · August 1, 2004 Featured Publication We report on the application of SUPREX (stability of unpurified proteins from rates of H/D exchange) to the analysis of a protein-ligand binding interaction under the ex vivo solution conditions of a human lung tumor tissue lysate. A SUPREX-derived binding ... Full text Link to item Cite

Clinical utility of serum amyloid A and macrophage migration inhibitory factor as serum biomarkers for the detection of nonsmall cell lung carcinoma.

Journal Article Cancer · July 15, 2004 BACKGROUND: Early lung carcinoma detection strategies involving imaging studies have yet to demonstrate a reduction in mortality. Identification of serum biomarkers that could complement radiologic studies and facilitate earlier diagnosis of lung carcinoma ... Full text Link to item Cite

Comparison of whole-body FDG-PET to bone scan for detection of bone metastases in patients with a new diagnosis of lung cancer.

Journal Article Lung Cancer · June 2004 The purpose of this study was to compare the accuracy and agreement of whole-body positron-emission tomography (PET) scan to bone scintigraphy for the detection of bony metastases in staging patients with newly diagnosed lung cancer. The tumor registry and ... Full text Link to item Cite

Estimate of lung cancer mortality from low-dose spiral computed tomography screening trials: implications for current mass screening recommendations.

Journal Article J Clin Oncol · June 1, 2004 Featured Publication PURPOSE: Low-dose computed tomography (CT) has been suggested for lung cancer screening. Several observational trials have published their preliminary results, and some investigators suggest that this technique will save lives. There are no mortality stati ... Full text Link to item Cite

False-negative findings for primary lung tumors on FDG positron emission tomography: staging and prognostic implications.

Journal Article AJR Am J Roentgenol · May 2004 OBJECTIVE: The aim of this study was to determine the stage and outcome of patients with primary lung tumors who had a negative finding on a FDG positron emission tomography (PET) study at the time of diagnosis. MATERIALS AND METHODS: A total of 3912 patie ... Full text Link to item Cite

Identification and validation of a potential lung cancer serum biomarker detected by matrix-assisted laser desorption/ionization-time of flight spectra analysis.

Journal Article Proteomics · September 2003 Many abnormalities detected in the thorax by routine conventional imaging studies are benign, yet all require further evaluation because of the concern for cancer. To address this deficiency and develop a serum biomarker for lung cancer, we designed a matr ... Full text Link to item Cite

Analysis of human serum proteins by liquid phase isoelectric focusing and matrix-assisted laser desorption/ionization-mass spectrometry.

Journal Article Proteomics · September 2003 Direct matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) analysis of human serum yielded ion signals from only a fraction of the total number of peptides and proteins expected to be in the sample. We increased the ... Full text Link to item Cite

Exploring the proteome with MALDI-TOF

Journal Article Proteomics · September 1, 2003 Cite

Conflict of interest.

Journal Article Am J Respir Crit Care Med · September 1, 2003 Full text Link to item Cite

Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer.

Journal Article Cancer Res · April 1, 2003 Featured Publication Current diagnostic and therapeutic strategies for lung cancer have had no significant impact on lung cancer mortality over the last several decades. This study used a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF M ... Link to item Cite

Use of mixture models in MALDI-TOF proteomic data for peak registration

Conference PROCEEDINGS OF THE 7TH JOINT CONFERENCE ON INFORMATION SCIENCES · January 1, 2003 Link to item Cite

Conflict of interest

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · 2003 Cite

Potential conflict of interest in AJRCCM.

Journal Article Am J Respir Crit Care Med · December 15, 2002 Featured Publication Full text Link to item Cite

Potential conflict of interest in AJRCCM

Journal Article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · December 15, 2002 Link to item Cite

PET imaging in patients with bronchioloalveolar cell carcinoma.

Journal Article Lung Cancer · December 2002 Featured Publication OBJECTIVE: Focal bronchioloalveolar cell carcinoma (BAC) has been reported as often being negative on 2-[fluorine-18] fluoro-2-deoxy-D-glucose (FDG-PET) scans, but no studies have examined the FDG-PET findings of both the focal and multifocal forms of the ... Full text Link to item Cite

A fractionation protocol to reduce signal suppression effects in the MALDI analysis of blood proteins

Journal Article Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics · December 1, 2002 A protocol involving the combination of liquid-phase isoelectric focusing and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) was developed. Liquid-phase isoelectric focusing was used to separate serum peptides a ... Cite

Mortality rate and screening.

Journal Article Radiology · September 2002 Full text Link to item Cite

Mortality rate and screening - Response

Journal Article RADIOLOGY · September 1, 2002 Link to item Cite

Development of novel tumor imaging agents with phage-display combinatorial peptide libraries.

Journal Article Acad Radiol · August 2002 Featured Publication RATIONALE AND OBJECTIVES: Current radiologic methods do not provide sufficient information for unambiguous diagnosis and prognosis of cancer. The present investigation sought to address this deficiency by developing a system for designing novel small molec ... Full text Link to item Cite

T1 lung cancers: sensitivity of diagnosis with fluorodeoxyglucose PET.

Journal Article Radiology · May 2002 Featured Publication PURPOSE: To determine the sensitivity of fluorodeoxyglucose (FDG) positron emission tomography (PET) in patients with T1 (< or =3 cm) lung cancers. MATERIALS AND METHODS: One hundred eighty-five patients with 192 histopathologically proved T1 lung cancers ... Full text Link to item Cite

The role of imaging in malignant pleural mesothelioma.

Journal Article Semin Oncol · February 2002 Featured Publication Imaging plays an essential role in the diagnosis, staging, and follow-up of patients with malignant pleural mesothelioma (MPM). The diagnosis is often suggested by a unilateral pleural mass with a moderate to large pleural effusion seen on chest radiograph ... Full text Link to item Cite

Stage distribution in patients with a small (< or = 3 cm) primary nonsmall cell lung carcinoma. Implication for lung carcinoma screening.

Journal Article Cancer · December 15, 2001 Featured Publication BACKGROUND: Recently, there has been increased interest in the use of computed tomography (CT) for lung carcinoma screening. For this technique to be effective, small tumors must be detected at an earlier stage than large lesions. However, to the authors's ... Full text Link to item Cite

CT screening for lung cancer: not ready for routine practice.

Journal Article Radiology · December 2001 Featured Publication Lung cancer continues to be a major worldwide health problem. Multiple strategies are being explored in an attempt to reduce lung cancer mortality, including a renewed interest in screening. Multiple low-dose spiral computed tomography (CT) trials have bee ... Full text Link to item Cite

Stage distribution in patients with a small (

Journal Article Cancer · December 2001 BACKGROUND: Recently, there has been increased interest in the use of computed tomography (CT) for lung carcinoma screening. For this technique to be effective, small tumors must be detected at an earlier stage than large lesions. However, to the authors's ... Cite

Identification of small lung nodules at autopsy: implications for lung cancer screening and overdiagnosis bias.

Journal Article Lung Cancer · July 2001 Featured Publication PURPOSE: Unsuspected cases of lung cancer are reported to be uncommon in autopsy series, and these data have been used to suggest that indolent tumors are rare and that overdiagnosis bias is not an important factor in lung cancer screening. The purpose of ... Full text Link to item Cite

FDG-PET imaging in patients with paraneoplastic syndromes and suspected small cell lung cancer.

Journal Article J Thorac Imaging · April 2001 Featured Publication Paraneoplastic syndromes may be the presenting clinical manifestation of small cell lung cancer. In some cases, however, confirming the diagnosis can be difficult because findings on conventional imaging studies can be subtle or nonspecific. This study exa ... Full text Link to item Cite

Screening for lung cancer.

Journal Article N Engl J Med · March 22, 2001 Link to item Cite

Screening for lung cancer.

Journal Article N Engl J Med · March 22, 2001 Full text Link to item Cite

Screening for lung cancer. Reply

Journal Article NEW ENGLAND JOURNAL OF MEDICINE · March 22, 2001 Link to item Cite

Low-dose spiral computed tomography screening for lung cancer: not ready for prime time.

Journal Article Am J Respir Crit Care Med · March 2001 Featured Publication Full text Link to item Cite

Management of spontaneous pneumothorax: an American College of Chest Physicians Delphi consensus statement.

Journal Article Chest · February 2001 OBJECTIVE: Provide explicit expert-based consensus recommendations for the management of adults with primary and secondary spontaneous pneumothoraces in an emergency department and inpatient hospital setting. The use of opinion was made explicit by employi ... Full text Link to item Cite

Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer.

Journal Article Lung Cancer · 2001 Featured Publication PURPOSE: To correlate FDG activity on PET with the expression of glucose transporter proteins Glut-1 and Glut-3 in patients with early stage non-small cell lung cancer (NSCLC). METHODS: Over a 5 year period, all patients with a PET scan and clinical stage ... Full text Link to item Cite

Integration of peripheral blood biomarkers with computed tomography to differentiate benign from malignant pulmonary opacities.

Journal Article Cancer Detect Prev · 2001 Featured Publication Our purpose was to determine whether peripheral blood biomarkers MUC1 and CK19 could be used to complement imaging studies in differentiating benign from malignant indeterminate pulmonary nodules or masses detected on computed tomography CT. One hundred an ... Link to item Cite

Commentary on Drs Miettinen and Henschke's viewpoint

Journal Article Radiology · January 1, 2001 We should first verify that this form of screening is indeed effective and that its benefits outweigh its harms. ... Full text Cite

Screening for lung cancer.

Journal Article N Engl J Med · November 30, 2000 Featured Publication Full text Link to item Cite

Staging techniques for lung cancer.

Journal Article Chest Surg Clin N Am · November 2000 In summary, noninvasive clinical staging techniques aid in stratifying patients into similar prognostic and therapeutic categories. Every patient with presumed non-small cell lung cancer should undergo a thorough history and physical examination, basic rou ... Link to item Cite

Design of a novel small peptide targeted against a tumor-specific receptor.

Journal Article Biochem Biophys Res Commun · August 28, 2000 EGFRvIII is the most common deletion variant of the epidermal growth factor receptor and is found in cancers of the brain, breast, ovary, and lung. The complete absence of the receptor in healthy tissues makes it an ideal tumor marker. We sought to design ... Full text Link to item Cite

FDG PET of pleural effusions in patients with non-small cell lung cancer.

Journal Article AJR Am J Roentgenol · July 2000 OBJECTIVE: We determined the ability of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) to differentiate benign and malignant pleural effusions in patients with non-small cell lung cancer. MATERIALS AND METHODS: Over a 6-year period, we rev ... Full text Link to item Cite

Lung cancer and positron emission tomography with fluorodeoxyglucose.

Journal Article Lung Cancer · June 2000 Over the past years, positron emission tomography (PET) with fluoro-2-deoxy-D-glucose (FDG) has emerged as an important imaging modality. In the thorax, FDG-PET has been shown to differentiate benign from malignant pulmonary lesions and stage lung cancer. ... Full text Link to item Cite

Correlation of tumor size and survival in patients with stage IA non-small cell lung cancer.

Journal Article Chest · June 2000 OBJECTIVE: The purpose of this study was to determine the relationship between tumor size and survival in patients with stage IA non-small cell lung cancer (non-small cell lung cancer; ie, lesions < 3 cm). METHOD: Five hundred ten patients with pathologic ... Full text Link to item Cite

Non-small cell lung cancer: FDG PET for nodal staging in patients with stage I disease.

Journal Article Radiology · June 2000 PURPOSE: To determine the accuracy of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in the evaluation of regional lymph nodes in patients with stage I non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: Imaging and ... Full text Link to item Cite

Imaging bronchogenic carcinoma.

Journal Article Chest · April 2000 Imaging plays an integral role in diagnosing, staging, and following patients with lung cancer. Most lung tumors are detected on chest radiographs, but unfortunately, the majority of patients have advanced stage disease at presentation. There is a wide spe ... Full text Link to item Cite

Management of malignant pleural effusions and pneumothorax.

Journal Article Radiol Clin North Am · March 2000 Pneumothorax may occur spontaneously or result from underlying lung disease or as a complication of interventional thoracic procedures. Percutaneous catheter placement enables safe and effective drainage of pneumothoraces with rapid relief of symptoms and ... Full text Link to item Cite

Prognostic value of thoracic FDG PET imaging after treatment for non-small cell lung cancer.

Journal Article AJR Am J Roentgenol · March 2000 OBJECTIVE: We determined the prognostic value of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for patients with treated lung cancer. MATERIALS AND METHODS: We examined patients who underwent FDG PET after first-line treatment for non-sma ... Full text Link to item Cite

From the guest editor

Journal Article Journal of Thoracic Imaging · January 13, 2000 Full text Cite

Lung nodule enhancement at CT: multicenter study.

Journal Article Radiology · January 2000 PURPOSE: To test the hypothesis that absence of statistically significant lung nodule enhancement (< or =15 HU) at computed tomography (CT) is strongly predictive of benignity. MATERIALS AND METHODS: Five hundred fifty lung nodules were studied. Of these, ... Full text Link to item Cite

Lung nodules: dual-kilovolt peak analysis with CT--multicenter study.

Journal Article Radiology · January 2000 PURPOSE: To test the following hypothesis: The greater the increase in the mean computed tomographic (CT) number of a radiologically indeterminate lung nodule from the CT number on a 140-kVp CT image to that on an 80-kVp CT image, the more likely the nodul ... Full text Link to item Cite

FDG-PET in patient with clinical T1N0 lung cancer; Determination of nodal status

Journal Article Japanese Journal of Clinical Radiology · January 1, 2000 To assess the usefulness of FDG-PET for evaluating N-factor in small lung cancer, we focused the object to clinical T1N0 cases. Twenty-two patients were eligible for this study. Six of 22 patients were positive for nodal metastasis pathologically. FDG-PET ... Cite

Clinical T1 lung cancer; evaluation with FDG-PET

Journal Article Japanese Journal of Clinical Radiology · January 1, 2000 To determine the usefulness of F-18 FDG-PET for small size lesions of lung cancer, 38 clinical T1 patients were semiquantitatively analyzed by standardized uptake ratios (SUR). Using an SUR greater than 2.5 as criteria for malignancy, positive ratios were ... Cite

Positron emission tomography imaging in the thorax.

Journal Article Clin Chest Med · December 1999 Positron emission tomography imaging has proven valuable in the evaluation and management of thoracic abnormalities. It is more accurate than CT or MR imaging in characterizing indeterminate focal abnormal pulmonary opacities, staging lung cancer, and asse ... Full text Link to item Cite

Sclerotherapy for malignant pleural effusions

Journal Article Pneumologie · December 1, 1999 Cite

Sclerotherapy for malignant pleural effusions

Journal Article Pneumologie · December 1, 1999 Cite

PET imaging in the thorax

Journal Article Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings · December 1, 1999 Positron emission tomography (PET) is an important imaging modality for the evaluation and management of thoracic abnormalities. It provides not only anatomic but physiologic information that supplements conventional radiologic imaging. While PET with 18F- ... Cite

Thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation: incidence and significance in patients with breast cancer.

Journal Article AJR Am J Roentgenol · November 1999 OBJECTIVE: The purpose of this study was to determine the incidence and clinical significance of thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation for treatment of metastatic or high-risk primary (with at least four p ... Full text Link to item Cite

Imaging lung cancer.

Journal Article Semin Oncol · October 1999 Imaging plays an essential role in diagnosing, staging, and following patients with lung cancer. Most tumors are found on chest radiographs, although further evaluation with thoracic computed tomography is performed to stage local disease. Additional radio ... Link to item Cite

Radiologic findings of bronchogenic carcinoma with pulmonary metastases at presentation.

Journal Article Clin Radiol · October 1999 PURPOSE: To describe the radiologic findings in patients with primary bronchogenic carcinoma and pulmonary metastases at presentation. MATERIALS AND METHODS: A retrospective review of patients with bronchogenic carcinoma who at presentation had pulmonary m ... Full text Link to item Cite

Non-small cell lung cancer: FDG-PET imaging.

Journal Article J Thorac Imaging · October 1999 Positron emission tomography is a clinically useful imaging modality that complements conventional radiologic studies in the evaluation of focal pulmonary opacities, lung cancer staging, tumor recurrence, treatment response, and prognosis. ... Full text Link to item Cite

Imaging lung cancer

Journal Article SEMINARS IN ONCOLOGY · October 1, 1999 Link to item Cite

Staging non-small cell lung cancer with whole-body PET.

Journal Article Radiology · September 1999 PURPOSE: To compare the accuracies of whole-body 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) and conventional imaging (thoracic computed tomography [CT], bone scintigraphy, and brain CT or magnetic resonance [MR] imagin ... Full text Link to item Cite

Thoracic manifestations of breast carcinoma: metastatic disease and complications of treatment.

Journal Article Clin Radiol · August 1999 Breast cancer, a common malignancy in women, is a major cause of cancer-related deaths. Metastases to the thorax are common in patients with breast cancer. Metastases can manifest radiographically as pulmonary nodules, lymphangitis carcinomatosa, endobronc ... Full text Link to item Cite

Positron emission tomography imaging in lung cancer.

Journal Article Clin Lung Cancer · August 1999 Over the past several years, positron emission tomography (PET) has become a clinically useful, noninvasive study which complements conventional imaging (chest radiographs, computed tomography [CT], and magnetic resonance imaging [MRI]) in the evaluation o ... Full text Link to item Cite

Treatment of malignant pleural effusions.

Journal Article Curr Opin Pulm Med · July 1999 Malignant pleural effusions are common in cancer patients with advanced disease. These patients usually present with chest pain, cough, and progressive shortness of breath, all of which may cause significant impairment in quality of life. Therapeutic optio ... Full text Link to item Cite

Lung cancer staging and management: comparison of contrast-enhanced and nonenhanced helical CT of the thorax.

Journal Article Radiology · July 1999 PURPOSE: To determine whether contrast material-enhanced helical computed tomography (CT) of the thorax and upper abdomen changes the tumor stage and management compared with nonenhanced helical CT in patients with newly diagnosed lung cancer. MATERIALS AN ... Full text Link to item Cite

Positron emission tomographic imaging with fluorodeoxyglucose isefficacious in evaluating malignant pulmonary disease.

Journal Article J Thorac Cardiovasc Surg · April 1999 OBJECTIVE: Positron emission tomography (PET), when used with the intravenously administered radiopharmaceutical F-18 fluorodeoxyglucose (FDG), has the potential to help in the evaluation of patients with lung cancer because the radiopharmaceutical is conc ... Full text Link to item Cite

Multimodality nuclear medicine imaging in three-dimensional radiation treatment planning for lung cancer: challenges and prospects.

Journal Article Lung Cancer · February 1999 The purpose of this study was to determine the utility of quantitative single photon emission computed tomography (SPECT) lung perfusion scans and F-18 fluorodeoxyglucose positron emission computed tomography (PET) during X-ray computed tomography (CT)-bas ... Full text Link to item Cite

Malignant pleural effusions: treatment with small-bore-catheter thoracostomy and talc pleurodesis.

Journal Article Radiology · January 1999 Thirty-two patients with a known primary malignancy and a symptomatic malignant pleural effusion underwent small-bore-catheter thoracostomy and talc pleurodesis. Twenty-three patients (72%) had a complete response; four (12%), a partial response; and five ... Full text Link to item Cite

Pulmonary nontuberculous mycobacterial infection: radiologic manifestations.

Journal Article Radiographics · 1999 The nontuberculous mycobacteria (NTMB) are a group of bacteria that can infect the cervical lymph nodes, skin, soft tissues, and lung. Pulmonary NTMB disease is increasing in prevalence and is most commonly caused by Mycobacterium avium-intracellulare or M ... Full text Link to item Cite

Imaging lung cancer

Journal Article Seminars in Oncology · January 1, 1999 Imaging plays an essential role in diagnosing, staging, and following patients with lung cancer. Most tumors are found on chest radiographs, although further evaluation with thoracic computed tomography is performed to stage local disease. Additional radio ... Cite

Non-small cell lung cancer: FDG-PET imaging

Journal Article Journal of Thoracic Imaging · January 1, 1999 Positron emission tomography is a clinically useful imaging modality that complements conventional radiologic studies in the evaluation of focal pulmonary opacities, lung cancer staging, tumor recurrence, treatment response, and prognosis. © 1999 Lippincot ... Full text Cite

Lung cancer, Part I: From the guest editor

Journal Article Journal of Thoracic Imaging · January 1, 1999 Full text Cite

Radiosynthesis and in-vivo evaluation of the pseudopeptide δ-opioid antagonist [125I]-ITIPP(Ψ)

Journal Article Journal of Labelled Compounds and Radiopharmaceuticals · January 1, 1999 Cite

Bronchial anastomotic complications in lung transplant recipients: virtual bronchoscopy for noninvasive assessment.

Journal Article Radiology · December 1998 PURPOSE: To compare the accuracy of virtual bronchoscopy (VB) with that of axial computed tomography (CT) in the assessment of bronchial anastomotic complications in lung transplant recipients. MATERIALS AND METHODS: Twenty-seven bronchial anastomoses in 1 ... Full text Link to item Cite

The prognostic significance of fluorodeoxyglucose positron emission tomography imaging for patients with nonsmall cell lung carcinoma.

Journal Article Cancer · September 1, 1998 BACKGROUND: A fundamental property of malignant tumors is increased glucose metabolism, which can be estimated by imaging the glucose analog fluorodeoxyglucose (FDG). The aim of this study was to determine whether FDG uptake in lung carcinoma, as measured ... Link to item Cite

Cytologically proved malignant pleural effusions: distribution of transudates and exudates.

Journal Article Chest · May 1998 PURPOSE: This study attempts to determine the distribution of transudates vs exudates in pathologically proved malignant pleural effusions and the necessity for cytologic studies in patients with a transudative effusion. MATERIALS AND METHODS: A retrospect ... Full text Link to item Cite

Evaluation of primary pulmonary carcinoid tumors using FDG PET.

Journal Article AJR Am J Roentgenol · May 1998 OBJECTIVE: The purpose of this study was to determine the spectrum of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) findings in patients who have primary pulmonary carcinoid tumors. CONCLUSION: On FDG PET imaging, pulmonary carcinoid ... Full text Link to item Cite

Sclerotherapy for malignant pleural effusions: a prospective randomized trial of bleomycin vs doxycycline with small-bore catheter drainage.

Journal Article Chest · May 1998 Featured Publication BACKGROUND: Malignant pleural effusions are a common problem for patients with metastatic disease. Most patients are treated with tube thoracostomy and sclerotherapy, although there remains no standard approach. The purpose of this study was to compare the ... Full text Link to item Cite

Molecular characterization of the human δ opioid receptor in lung cancer

Journal Article Anticancer Research · May 1, 1998 A variety of neuropeptide receptors have been detected in human lung cancer. They are thought to play a role in autocrin/paracrine regulation of cell growth, and may be clinically useful a diagnostic, prognostic or therapeutic targets. The current study ch ... Cite

Percutaneous drainage of pleural collections.

Journal Article J Thorac Imaging · April 1998 Pneumothorax is a frequent complication of interventional pulmonary procedures. Percutaneous catheter placement enables safe and effective drainage of pneumothoraces with rapid restoration of vital capacity, oxygenation, and lung reexpansion. ... Full text Link to item Cite

Prospective investigation of positron emission tomography in lung nodules.

Journal Article J Clin Oncol · March 1998 PURPOSE: Solitary pulmonary nodules (SPNs) are commonly identified by chest radiographs and computed tomography (CT). Biopsies are often performed to evaluate the nodules further. An accurate, noninvasive diagnostic test could avoid the morbidity and costs ... Full text Link to item Cite

Imaging of the solitary pulmonary nodule

Journal Article Seminars in Respiratory and Critical Care Medicine · January 1, 1998 The solitary pulmonary nodule continues to be a common finding on radiographic studies. In order to determine etiology, diagnostic evaluation begins with comparison with old films in an attempt to demonstrate at least 2-year stability. If this cannot be es ... Full text Cite

Imaging of mediastinal lymph nodes: CT, MR, and FDG PET.

Journal Article Radiographics · 1998 The evaluation of mediastinal lymph nodes is an important aspect of staging in patients with non-small cell lung cancer. Anatomic imaging of lymph nodes with computed tomography (CT) and magnetic resonance (MR) imaging has been limited by the relatively lo ... Full text Link to item Cite

Molecular characterization of the human delta opioid receptor in lung cancer.

Journal Article Anticancer Res · 1998 A variety of neuropeptide receptors have been detected in human lung cancer. They are thought to play a role in autocrine/paracrine regulation of cell growth, and may be clinically useful as diagnostic, prognostic or therapeutic targets. The current study ... Link to item Cite

Malignant pleural effusions: recent advances and ambulatory sclerotherapy.

Journal Article Chest · January 1998 Malignant pleural effusions are a common problem in cancer patients with advanced disease. Patients typically present with progressive dyspnea, cough, and/or chest pain that significantly compromises their quality of life. Treatment is often palliative, us ... Full text Link to item Cite

Imaging features of nonmyxomatous primary neoplasms of the heart and pericardium.

Journal Article Clin Imaging · 1998 We present the imaging findings in 13 patients with nonmyxomatous primary neoplasms of the heart and pericardium. Ten patients had abnormal chest films. While echocardiography was useful for determining origin of the tumor, CT (computed tomography) and MRI ... Full text Link to item Cite

Evaluation of patients with round atelectasis using 2-[18F]-fluoro-2-deoxy-D-glucose PET.

Journal Article J Comput Assist Tomogr · 1998 PURPOSE: Our goal was to determine the spectrum of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) PET findings in patients with round atelectasis (RA). METHOD: All patients from 1992 to 1997 with radiologic features of RA and FDG-PET scans were evaluated. There wer ... Full text Link to item Cite

Thoracic imaging features of patients with antiphospholipid antibodies.

Journal Article J Comput Assist Tomogr · 1998 PURPOSE: Our aim was to determine the thoracic manifestations of patients with antiphospholipid antibodies (APAs). METHOD: We performed a retrospective review of the clinical records and thoracic imaging studies of 88 patients (63 women, 25 men; mean age 4 ... Full text Link to item Cite

Thoracic FDG PET: state of the art.

Journal Article Radiographics · 1998 The D-glucose analogue 2-(fluorine-18) fluoro-2-deoxy-D-glucose (FDG) is the most commonly used radionuclide in positron emission tomography (PET) of the thorax. Increased glucose metabolism by malignant cells allows physiologic differentiation between ben ... Full text Link to item Cite

Malignant pleural effusions: Recent advances and ambulatory sclerotherapy

Journal Article Chest · January 1, 1998 Malignant pleural effusions are a common problem in cancer patients with advanced disease. Patients typically present with progressive dyspnea, cough, and/or chest pain that significantly compromises their quality of life. Treatment is often palliative, us ... Cite

Imaging of the solitary pulmonary nodule

Journal Article Seminars in Respiratory and Critical Care Medicine · 1998 The solitary pulmonary nodule continues to be a common finding on radiographic studies. In order to determine etiology, diagnostic evaluation begins with comparison with old films in an attempt to demonstrate at least 2-year stability. If this cannot be es ... Cite

Radioiodinated (+)-4-[(αR)-α-[(2S, 5R)-4-(iodopropen-2-yl)-2,5- dimethyl-1-piperazinyl]-3-hydroxybenzyl]-N, N-diethylbenzamide: A potential ligand for in vitro and in vivo investigations of δ-opioid receptors

Journal Article Journal of Labelled Compounds and Radiopharmaceuticals · January 1, 1998 (+)-4-[(αR)-α-[(2S, 5R)-4-(Iodopropen-2-yl)-2,5-dimethyl-1- piperazinyl]-3-hydroxybenzyl]-N, N-diethylbenzamide (1), a novel radioiodinated derivative of the selective δ-opioid antagonist (+)-BW373U86, was synthesized and evaluated in vitro for binding to ... Full text Cite

CT appearance of the pleural space after talc pleurodesis.

Journal Article AJR Am J Roentgenol · July 1997 OBJECTIVE: This study describes the CT appearance of the pleural space after talc pleurodesis. CONCLUSION: After talc pleurodesis, the pleural space reveals variable degrees of pleural thickening and nodularity, often with a residual loculated effusion. Hi ... Full text Link to item Cite

Pulmonary mucormycosis: radiologic findings in 32 cases.

Journal Article AJR Am J Roentgenol · June 1997 OBJECTIVE: The purpose of this study was to characterize the radiologic manifestations of pulmonary mucormycosis with clinical and pathologic correlation. MATERIALS AND METHODS: Clinical records, pathology reports, chest radiographs, and CT scans of 32 cas ... Full text Link to item Cite

Evaluation of adrenal masses in patients with bronchogenic carcinoma using 18F-fluorodeoxyglucose positron emission tomography.

Journal Article AJR Am J Roentgenol · May 1997 OBJECTIVE: The purpose of this study was to assess the usefulness of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) when differentiating benign from metastatic adrenal masses in patients with bronchogenic carcinoma. SUBJECTS AND METHO ... Full text Link to item Cite

Pulmonary abnormalities and PET data analysis: a retrospective study.

Journal Article Radiology · February 1997 PURPOSE: To assess methods of standard uptake ratio (SUR) calculation with 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) positron emission tomography (PET) in indeterminate focal pulmonary abnormalities. MATERIALS AND METHODS: One hundred ninety-seven adul ... Full text Link to item Cite

Diffuse nodular lung disease on chest radiographs: a pilot study of characterization by fractal dimension.

Journal Article AJR Am J Roentgenol · November 1996 OBJECTIVE: We present a computer-aided diagnostic technique for identifying nodular interstitial lung disease on chest radiographs. The fractal dimension was used as a numerical measure of image texture on digital chest radiographs to distinguish patients ... Full text Link to item Cite

State-of-the-art imaging of pulmonary embolic disease

Journal Article RADIOLOGY · November 1, 1996 Link to item Cite

Thoracic FDG PET: State of the art

Journal Article RADIOLOGY · November 1, 1996 Link to item Cite

Pulmonary venoocclusive disease: CT findings in eight patients.

Journal Article AJR Am J Roentgenol · October 1996 OBJECTIVE: The objective of the study was to describe the CT findings of pulmonary venoocclusive disease. MATERIALS AND METHODS: Eight patients with CT scans of the thorax and a diagnosis of pulmonary venoocclusive disease were identified from three instit ... Full text Link to item Cite

Binding of [3H](+)-BW373U86 to delta-opioid receptors in rat brain membranes.

Journal Article Eur J Pharmacol · August 29, 1996 A tritiated form of the non-peptide delta-opioid receptor agonist (+)-BW373U86 ((+)-4-((alpha-R)-alpha-((2S,5R)-4-allyl-2, 5-dimethyl-l-piperazinyl)-3-hydroxybenzyl)-N,N-diethylbenzamide) was synthesized and its binding characteristics studied. [3H](+)-BW3 ... Full text Link to item Cite

Positron emission tomography in the pretreatment evaluation and follow-up of non-small cell lung cancer patients treated with radiotherapy: preliminary findings.

Journal Article Am J Clin Oncol · August 1996 The purpose of this study was to prospectively evaluate positron emission tomography (PET) for delineating lung cancers preradiotherapy and to assess PET's ability to distinguish residual tumor from scarring following radiotherapy. Between April 1991 and O ... Full text Link to item Cite

A rational approach to the solitary pulmonary nodule

Journal Article Patient Care · July 15, 1996 Follow a path of diminishing uncertainty when a patient has a solitary pulmonary nodule. Ideally, malignant nodules will be resected promptly and benign ones identified with minimal intervention. ... Cite

Complications of lung transplantation: radiologic findings.

Journal Article AJR Am J Roentgenol · June 1996 The first clinically successful lung transplantation was performed in 1983. Since that time, more than 2700 transplants have been recorded by the International Lung Transplant Registry [1]. Lung transplantation is currently limited to patients with endstag ... Full text Link to item Cite

Pneumothorax after small-bore catheter placement for malignant pleural effusions.

Journal Article AJR Am J Roentgenol · May 1996 OBJECTIVE: The objective of this study was to evaluate the incidence and significance of pneumothorax after small-bore chest tube placement for symptomatic malignant pleural effusions. SUBJECTS AND METHODS: Over a 2-year period, 90 patients with a known pr ... Full text Link to item Cite

Characterization of delta opioid receptors in lung cancer using a novel nonpeptidic ligand.

Journal Article Cancer Res · April 1, 1996 Featured Publication Cancer cells are often characterized by the presence of membrane receptors not normally associated with nontransformed cells from the same tissue type. Recent studies have demonstrated increased expression of high-affinity binding sites for opioid receptor ... Link to item Cite

Ambulatory sclerotherapy for malignant pleural effusions.

Journal Article Radiology · April 1996 PURPOSE: To determine the feasibility of ambulatory drainage and sclerotherapy in malignant pleural effusions. MATERIALS AND METHODS: Nineteen consecutive patients with symptomatic malignant pleural effusions were enrolled. None of the patients previously ... Full text Link to item Cite

Significance of hemoptysis following thrombolytic therapy for acute myocardial infarction.

Journal Article Chest · March 1996 PURPOSE: To describe the occurrence, cause, and significance of hemoptysis following thrombolytic therapy for acute myocardial infarction. PATIENTS AND METHODS: We retrospectively reviewed 2,634 patients presenting with acute myocardial infarction who rece ... Full text Link to item Cite

The proposed new international TNM staging system for malignant pleural mesothelioma: application to imaging.

Journal Article AJR Am J Roentgenol · February 1996 Malignant pleural mesothelioma (MPM) is an uncommon and usually fatal primary neoplasm of the pleura. In the past, response to standard therapy has been poor [1-3], but recent studies suggest that some patients may benefit from various therapeutic options, ... Full text Link to item Cite

Cytomegalovirus pneumonia in transplant patients: CT findings.

Journal Article J Comput Assist Tomogr · 1996 OBJECTIVE: Our goal was to assess the CT findings of cytomegalovirus (CMV) pneumonia in transplant patients. MATERIALS AND METHODS: The study included 10 transplant patients who had chest CT scan and pathologically proven isolated pulmonary CMV infection. ... Full text Link to item Cite

Transthoracic fine needle aspiration biopsy. Sensitivity in relation to guidance technique and lesion size and location.

Journal Article Acta Cytol · 1996 OBJECTIVE: To obtain site- and size-specific data on transthoracic fine needle aspiration (TFNA) and determine the sensitivity in relation to guidance technique and lesion size and location. STUDY DESIGN: Data on 112 patients undergoing TFNA between 1992 a ... Full text Link to item Cite

Prospective comparison of helical CT and MR imaging in clinically suspected acute pulmonary embolism.

Journal Article J Magn Reson Imaging · 1996 The purpose of this study is to compare sensitivity and specificity of helical CT and MR imaging for detecting acute pulmonary embolism(PE). Patients who were suspected clinically of having PE were randomly assigned to undergo either helical contrast-enhan ... Full text Link to item Cite

Calcifying fibrous pseudotumor of pleura: radiologic features in three cases.

Journal Article J Comput Assist Tomogr · 1996 PURPOSE: Our goal was to describe the radiologic features of calcifying fibrous pseudotumor (CEPT) of pleura. METHOD: Chest radiographs and CT images of three patients, aged 23-34 years, with pathologically proven CFPT of pleura were reviewed with regard t ... Full text Link to item Cite

Thoracic nodal staging with PET imaging with 18FDG in patients with bronchogenic carcinoma.

Journal Article Chest · December 1995 PURPOSE: To assess the role of positron emission tomographic (PET) imaging with 18-fluoro-2-deoxyglucose (18FDG) in detecting thoracic lymph node metastases in patients with bronchogenic carcinoma. MATERIALS AND METHODS: Over a 2-year period, any patient p ... Full text Link to item Cite

Lung tumor growth correlates with glucose metabolism measured by fluoride-18 fluorodeoxyglucose positron emission tomography.

Journal Article Ann Thorac Surg · November 1995 BACKGROUND: The growth rate, or doubling time, of radiographically indeterminate pulmonary abnormalities is an important determinant of malignancy. Prospective calculation of doubling time, however, delays diagnosis and treatment. Positron emission tomogra ... Full text Link to item Cite

A proposed new international TNM staging system for malignant pleural mesothelioma. From the International Mesothelioma Interest Group.

Journal Article Chest · October 1995 STUDY OBJECTIVE: Investigation of the behavior and treatment of the diffuse malignant pleural mesothelioma (MPM) is hindered by the lack of an accurate universally accepted staging system. To address this problem, the International Mesothelioma Interest Gr ... Full text Link to item Cite

Pulmonary manifestations of nontuberculous Mycobacterium.

Journal Article Radiol Clin North Am · July 1995 Thoracic nontuberculous or atypical mycobacterial infections typically occur in patients who have underlying lung disease or an immunologic abnormality. These infections are usually indolent and the diagnosis is often difficult to establish and, even if co ... Link to item Cite

Detection of primary and recurrent lung cancer by means of F-18 fluorodeoxyglucose positron emission tomography (FDG PET).

Journal Article J Thorac Cardiovasc Surg · July 1995 Positron emission tomography (PET), with the glucose analog F-18 fluoro-deoxyglucose (FDG), takes advantage of the enhanced glucose uptake observed in neoplastic cells. We examined whether the detection of preferential FDG uptake with PET permits different ... Full text Link to item Cite

Palliative treatment of malignant pleural effusions: value of small-bore catheter thoracostomy and doxycycline sclerotherapy.

Journal Article AJR Am J Roentgenol · March 1995 OBJECTIVE: This study evaluates small-bore catheter thoracostomy combined with doxycycline sclerotherapy for palliative treatment of presumed malignant pleural effusions. SUBJECTS AND METHODS: Forty-seven consecutive patients referred from the medical onco ... Full text Link to item Cite

Significance of percutaneous needle biopsy in patients with multiple pulmonary nodules and a single known primary malignancy.

Journal Article Chest · March 1995 OBJECTIVE: To determine the necessity of percutaneous lung biopsy in patients with a single known primary malignancy and multiple pulmonary nodules. DESIGN: Retrospective study. SETTING: Tertiary care university hospital. RESULTS: We reviewed all percutane ... Full text Link to item Cite

Detection of pulmonary embolism: comparison of contrast-enhanced spiral CT and time-of-flight MR techniques.

Journal Article J Thorac Imaging · 1995 We compared the conspicuity of acute pulmonary emboli with contrast-enhanced spiral computed tomography (CT) and two- and three-dimensional time-of-flight magnetic resonance (MR) techniques. Seven dogs who received experimental pulmonary emboli and one con ... Link to item Cite

Congenital cystic adenomatoid malformation in adults: CT findings.

Journal Article J Comput Assist Tomogr · 1995 OBJECTIVE: Congenital cystic adenomatoid malformation (CAM) of the lung usually presents in children, although it has rarely been described in adults. The aim of this study was to review the clinical history and the CT findings in adults with pathologicall ... Full text Link to item Cite

Atypical and unusual calcifications of the heart and great vessels: imaging findings.

Journal Article AJR Am J Roentgenol · December 1994 Cardiovascular calcifications in the thorax may be clinically significant and may prove extremely valuable diagnostically. The typical appearance and location of common cardiovascular calcifications have been well described [1, 2]. We present a series of r ... Full text Link to item Cite

Semiquantitative and visual analysis of FDG-PET images in pulmonary abnormalities.

Journal Article J Nucl Med · November 1994 UNLABELLED: FDG PET images of the thorax can be analyzed semiquantitatively using standardized uptake ratios (SUR) or activity ratios between abnormal and normal tissue, or qualitatively by visual comparison of the abnormality to normal structures. Standar ... Link to item Cite

Positron emission tomography imaging of the thorax.

Journal Article Radiol Clin North Am · July 1994 Positron emission tomography (PET) is just beginning to emerge as a clinically useful tool in the thorax. Imaging with FDG is used primarily to differentiate benign from malignant abnormalities, including solitary pulmonary nodules, staging bronchogenic ca ... Link to item Cite

CT of the lung: patterns of calcification and other high-attenuation abnormalities.

Journal Article AJR Am J Roentgenol · May 1994 CT is the most sensitive radiologic method for the detection of differences in radiographic density in chest lesions. Areas of high attenuation (visually as opaque as bony structures) in an abnormality on CT scans can be an important clue to the correct di ... Full text Link to item Cite

Persistent or recurrent bronchogenic carcinoma: detection with PET and 2-[F-18]-2-deoxy-D-glucose.

Journal Article Radiology · May 1994 PURPOSE: To assess positron emission tomography (PET) with 2-[fluorine-18]-2-deoxy-D-glucose (FDG) in the differentiation of recurrent bronchogenic carcinoma from fibrosis after therapy. MATERIALS AND METHODS: Any patient treated for bronchogenic carcinoma ... Full text Link to item Cite

Thoracic lymphangioma in adults: CT and MR imaging features.

Journal Article AJR Am J Roentgenol · February 1994 OBJECTIVE: Lymphangiomas are rare benign tumors most often seen in childhood. When they occur in adults, radiologic diagnosis can be difficult. A retrospective study of the CT and MR appearances of thoracic lymphangiomas in adult patients was performed in ... Full text Link to item Cite

Pulmonary drug toxicity following high-dose chemotherapy with autologous bone marrow transplantation: CT findings in 20 cases.

Journal Article J Thorac Imaging · 1994 We retrospectively evaluated the computed tomography (CT) findings in 20 patients with pulmonary drug toxicity that followed high-dose chemotherapy and autologous bone marrow transplantation (ABMT). Eighty-five patients with Stage II or III breast cancer t ... Full text Link to item Cite

Cardiopulmonary complications of pregnancy: radiographic findings.

Journal Article AJR Am J Roentgenol · November 1993 Physiologic changes during pregnancy affect nearly every organ system. In the thorax, the diaphragm elevates as much as 4 cm because of displacement of the abdominal organs by the gravid uterus, resulting in lower lung volumes. Maternal blood volume and ca ... Full text Link to item Cite

Focal pulmonary abnormalities: evaluation with F-18 fluorodeoxyglucose PET scanning.

Journal Article Radiology · August 1993 The authors assessed the role of positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) in differentiation of benign from malignant focal pulmonary abnormalities seen on chest radiographs. Fifty-one patients underwent FDG PET scanning ... Full text Link to item Cite

DIFFERENTIATION OF BENIGN AND MALIGNANT PULMONARY OPACITIES WITH FDG-PET

Journal Article JOURNAL OF NUCLEAR MEDICINE · May 1, 1993 Link to item Cite

Variable compensation chest radiography performed with a computed radiography system: design considerations and initial clinical experience.

Journal Article Radiology · April 1993 The authors describe a variable compensation (VC) technique in which an x-ray equalizer and a computed radiography system are used. The VC technique allows retrospective alteration of equalized chest appearance with maintenance of improved signal-to-noise ... Full text Link to item Cite

Identification of internal mammary lymph nodes: value of the frontal chest radiograph.

Journal Article J Thorac Imaging · 1993 The article describes eight patients with enlarged internal mammary lymph nodes visualized on the frontal plain chest radiograph. Enlarged internal mammary lymph nodes cast shadows that initially may be mistaken for a mediastinal or pleural abnormality. Al ... Link to item Cite

Malignant pleural mesothelioma: value of CT and MR imaging in predicting resectability.

Journal Article AJR Am J Roentgenol · November 1992 OBJECTIVE: Our objective was to determine if CT or MR imaging findings could be used to accurately predict resectability in patients with biopsy-proved malignant pleural mesotheliomas. SUBJECTS AND METHODS: CT and MR findings in 41 consecutive patients wit ... Full text Link to item Cite

Pulmonary cryptococcosis.

Journal Article J Thorac Imaging · September 1992 Cryptococcus neoformans is a ubiquitous soil fungus that rarely causes pneumonia in normal hosts but is a common cause of opportunistic infection. Pulmonary disease is initiated by inhalation of the organism, and a spectrum of radiographic manifestations c ... Full text Link to item Cite

Pseudoaneurysms at aortic cannulation site after coronary artery bypass graft: MR findings.

Journal Article J Comput Assist Tomogr · 1992 Pseudoaneurysm at the aortic cannulation site is a rare but potentially fatal complication of coronary artery bypass surgery. We present two cases in which MRI provided significant information regarding the anatomy and extent of a pseudoaneurysm. In one ca ... Full text Link to item Cite

Radiopacity of glass.

Journal Article AJR Am J Roentgenol · February 1988 Full text Link to item Cite