Paul Simon Jowell

Journal article Dig Liver Dis · January 2006 Featured Publication BACKGROUND: Despite advances in imaging modalities, preoperative diagnosis of pancreatic cystic lesions remains difficult. AIM: To assess the accuracy of endoscopic ultrasound and computer tomography to preoperatively distinguish benign from potentially ma ... Full text Link to item Cite

Urgent colonoscopy for evaluation and management of acute lower gastrointestinal hemorrhage: a randomized controlled trial.

Journal article Am J Gastroenterol · November 2005 Featured Publication OBJECTIVES: We hypothesized that early intervention in patients with lower gastrointestinal bleeding (LGIB) would improve outcomes and therefore conducted a prospective randomized study comparing urgent colonoscopy to standard care. METHODS: Consecutive pa ... Full text Link to item Cite

Pancreatic FNA in 1000 cases: a comparison of imaging modalities.

Journal article Gastrointest Endosc · June 2005 Featured Publication BACKGROUND: Image-guided FNA is a popular method for evaluating pancreatic lesions, but few large studies on pancreatic FNA exist. METHODS: Cytologic material, imaging reports, and clinical follow-up information were reviewed from pancreatic FNA cases perf ... Full text Link to item Cite

EUS-guided FNA of pancreatic metastases: a multicenter experience.

Journal article Gastrointest Endosc · May 2005 Featured Publication BACKGROUND: Metastatic lesions of the pancreas are a rare but important cause of focal pancreatic lesions. The purpose of this study is to describe the EUS features, cytologic diagnoses, and clinical impact of a cohort of patients with pancreatic metastase ... Full text Link to item Cite

The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis.

Journal article Clin Lab Med · March 2005 Featured Publication This article reviews current concepts regarding the pathobiology of cystic fibrosis pancreatic disease. It summarizes recent studies on the relationship between CFTR mutations and pancreatitis, and it reviews several unresolved issues in the field. ... Full text Link to item Cite

The role of cystic fibrosis gene mutations in determining susceptibility to chronic pancreatitis.

Journal article Gastroenterol Clin North Am · December 2004 Featured Publication This article reviews current concepts regarding the pathobiology of cystic fibrosis pancreatic disease. It summarizes recent studies on the relationship between CFTR mutations and pancreatitis, and it reviews several unresolved issues in the field. ... Full text Link to item Cite

Yield of endoscopic ultrasound-guided fine-needle aspiration of bile duct lesions.

Journal article Endoscopy · August 2004 Featured Publication BACKGROUND AND STUDY AIMS: It is still difficult to differentiate reliably between benign and malignant biliary tract lesions. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has added to the diagnostic power of EUS for other gastrointestinal ... Full text Link to item Cite

Pancreatic duct strictures: identifying risk of malignancy.

Journal article Ann Surg Oncol · June 2004 Featured Publication BACKGROUND: This study aimed to define PDS characteristics that predict malignancy and would thus invoke further diagnostic evaluation or aggressive treatment. METHODS: 355 cases of PDS were diagnosed by ERCP during a 7-year period at a single institution. ... Full text Link to item Cite

Outcome of endoscopic minor papillotomy in patients with symptomatic pancreas divisum.

Journal article JOP · May 2004 Featured Publication CONTEXT: Pancreas divisum has been associated with recurrent acute pancreatitis, chronic abdominal pain without elevated pancreatic enzymes, and chronic pancreatitis. Prior studies suggest that endoscopic minor papillotomy benefits certain symptomatic panc ... Link to item Cite

The need for caution with topical anesthesia during endoscopic procedures, as liberal use may result in methemoglobinemia.

Journal article J Clin Gastroenterol · March 2004 Featured Publication During upper gastrointestinal endoscopy, topical oropharyngeal anesthesia with lidocaine and/or benzocaine is used routinely by many endodscopists. Although such a practice is usually safe, there have been a number of reports of methemoglobinemia induced b ... Full text Link to item Cite

Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA vs. percutaneous FNA.

Journal article Gastrointest Endosc · November 2003 Featured Publication BACKGROUND: Studies have suggested an increased risk of peritoneal seeding in patients with pancreatic cancer diagnosed by percutaneous FNA. EUS-FNA is an alternate method of diagnosis. The aim of this study was to compare the frequency of peritoneal carci ... Full text Link to item Cite

Percutaneous cholecystostomy in patients with acute cholecystitis: experience of 45 patients at a US referral center.

Journal article J Am Coll Surg · August 2003 Featured Publication BACKGROUND: Standard treatment for acute cholecystitis is cholecystectomy, but some patients are at high risk for immediate surgery. Percutaneous cholecystostomy might be the procedure of choice in this group. We reviewed the experience of percutaneous cho ... Full text Link to item Cite

A new synthetic porcine secretin for facilitation of cannulation of the dorsal pancreatic duct at ERCP in patients with pancreas divisum: a multicenter, randomized, double-blind comparative study.

Journal article Gastrointest Endosc · May 2003 Featured Publication BACKGROUND: Secretin, a 27 amino acid polypeptide released in response to duodenal luminal acidification, stimulates secretion of water and bicarbonate from pancreatic ductal cells. To date the only secretin available for clinical use has been a biological ... Full text Link to item Cite

Colonoscopy: practice variation among 69 hospital-based endoscopists.

Journal article Gastrointest Endosc · March 2003 Featured Publication BACKGROUND: The medical profession, payers, and patients are interested increasingly in the quality of endoscopic procedures, including colonoscopy. The American Society for Gastrointestinal Endoscopy has recommended "report cards" by which endoscopists ma ... Full text Link to item Cite

Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene.

Journal article J Investig Med · September 2002 Featured Publication Idiopathic chronic pancreatitis (ICP) is the leading cause of nonalcoholic chronic pancreatitis. This study examined a series of patients with ICP to determine the prevalence and role of mutations of the cystic fibrosis gene (CFTR) and of a trypsin inhibit ... Full text Link to item Cite

EUS-guided fine needle aspiration of the liver: indications, yield, and safety based on an international survey of 167 cases.

Journal article Gastrointest Endosc · June 2002 Featured Publication BACKGROUND: The liver is a common site of metastases for various malignancies. EUS-guided fine needle aspiration (EUS-FNA) of liver masses has only been reported in small series from single centers. METHODS: A retrospective questionnaire was sent by e-mail ... Full text Link to item Cite

Gastrointestinal imaging: endoscopic ultrasound.

Journal article Gastroenterology · May 2002 Featured Publication Full text Link to item Cite

ERCP-related perforations: risk factors and management.

Journal article Endoscopy · April 2002 Featured Publication BACKGROUND AND STUDY AIMS: Perforations during endoscopic retrograde cholangiopancreatography (ERCP) are rare, and the management of these perforations is variable, with some patients requiring immediate surgery and others only conservative management. We ... Full text Link to item Cite

Simple pancreatic cysts: CT and endosonographic appearances.

Journal article AJR Am J Roentgenol · April 2002 Featured Publication OBJECTIVE. This report describes the CT and endoscopic sonographic appearance of simple pancreatic cysts in three adults. CONCLUSION. Simple pancreatic cysts are typically an incidental finding in adults who have no history of pancreatic disease. The imagi ... Full text Link to item Cite

Yield of colonoscopy in patients with nonacute rectal bleeding: a multicenter database study of 1766 patients.

Journal article Am J Gastroenterol · February 2002 Featured Publication OBJECTIVE: There are few data to guide the choice between colonoscopy and flexible sigmoidoscopy in patients with nonacute rectal bleeding, especially in younger age groups. Our aim was to determine the yield of colonoscopy for significant proximal large b ... Full text Link to item Cite

Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations.

Journal article Gastroenterology · December 2001 Featured Publication BACKGROUND & AIMS: Nonalcoholic chronic pancreatitis is usually idiopathic and often associated with cystic fibrosis gene (CFTR) mutations. It is unknown whether pancreatitis risk correlates with having 1 or 2 CFTR mutations, abnormal epithelial ion transp ... Full text Link to item Cite

Age and alarm symptoms do not predict endoscopic findings among patients with dyspepsia: a multicentre database study.

Journal article Gut · July 2001 Featured Publication INTRODUCTION: Symptoms of dyspepsia are common but most patients do not have major upper gastrointestinal pathology. Endoscopy is recommended for dyspeptic patients over the age of 45, or those with certain "alarm" symptoms. We have evaluated the effective ... Full text Link to item Cite

Staging of pancreatic cancer before and after neoadjuvant chemoradiation.

Journal article J Gastrointest Surg · 2001 Featured Publication Neoadjuvant chemoradiation therapy is used at many institutions for treatment of localized adenocarcinoma of the pancreas. Accurate staging before neoadjuvant therapy identifies patients with distant metastatic disease, and restaging after neoadjuvant ther ... Full text Link to item Cite

A double-blind, randomized, dose response study testing the pharmacological efficacy of synthetic porcine secretin.

Journal article Aliment Pharmacol Ther · December 2000 Featured Publication BACKGROUND: Biologically derived porcine secretin has been used as a diagnostic agent in clinical gastrointestinal practice for many years. Pure synthetic porcine secretin is now available for investigational clinical use. AIM: To compare the pharmacology ... Full text Link to item Cite

A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer.

Journal article Int J Radiat Oncol Biol Phys · June 1, 2000 Featured Publication PURPOSE: To determine the feasibility of combining external beam radiotherapy, continuous infusion 5-fluorouracil (5-FU), and external microwave hyperthermia in patients with locally advanced, unresectable, or recurrent adenocarcinoma of the rectum. METHOD ... Full text Link to item Cite

Cystic fibrosis mutations and genetic predisposition to idiopathic chronic pancreatitis.

Journal article Med Clin North Am · May 2000 Featured Publication Idiopathic chronic pancreatitis is a leading cause of chronic pancreatitis. Work from this and other groups has shown that idiopathic chronic pancreatitis is associated with mutations of the cystic fibrosis gene (CFTR). Many idiopathic pancreatitis patient ... Full text Link to item Cite

Endoscopic ultrasound. State of the art.

Journal article N C Med J · 2000 Featured Publication Link to item Cite

Are mutations in the cystic fibrosis gene important in chronic pancreatitis?

Journal article Surg Clin North Am · August 1999 Featured Publication The leading causes of chronic pancreatitis are alcohol and idiopathic pancreatitis. The importance of genetic factors in chronic pancreatitis has been uncertain. Recently, however, it was learned that many patients with idiopathic chronic pancreatitis have ... Full text Link to item Cite

Relation between mutations of the cystic fibrosis gene and idiopathic pancreatitis.

Journal article N Engl J Med · September 3, 1998 Featured Publication BACKGROUND: It is unknown whether genetic factors predispose patients to idiopathic pancreatitis. In patients with cystic fibrosis, mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene typically cause pulmonary and pancreatic in ... Full text Link to item Cite

Quantitative assessment of procedural competence. A prospective study of training in endoscopic retrograde cholangiopancreatography.

Journal article Ann Intern Med · December 15, 1996 Featured Publication BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is a technically demanding procedure that can cause substantial complications. Competence in performing ERCP and the learning curve for achieving competence are poorly understood. OBJECTIVE: ... Full text Link to item Cite

Patient-controlled analgesia for conscious sedation during endoscopic retrograde cholangiopancreatography: a randomized controlled trial.

Journal article Gastrointest Endosc · May 1996 Featured Publication BACKGROUND: Adequate comfort is essential to patients undergoing invasive procedures. This study was designed to evaluate whether patient-controlled analgesia could improve sedation for ERCP. METHODS: Patients were randomized to receive standard sedation ( ... Full text Link to item Cite

Alteration in osteoblast activity and nutritional vitamin-D deficiency in non-hypercalcemic malignancy.

Journal article Calcif Tissue Int · January 1988 Featured Publication The biochemical parameters of bone mineral metabolism in patients with nonhypercalcemic malignancy have not been extensively investigated. Therefore, a group of 29 such patients with different types of malignancy was studied. Ten patients received corticos ... Full text Link to item Cite

1,25-Dihydroxyvitamin D3 modulates glucocorticoid-induced alteration in serum bone Gla protein and bone histomorphometry.

Journal article Endocrinology · February 1987 Featured Publication Glucocorticoid excess is associated with alterations in the vitamin D endocrine system. The aim of this study was to assess change in serum bone Gla protein (BGP) after low and high dose cortisone acetate treatment and to assess whether these alterations a ... Full text Link to item Cite